IMCLONE SYSTEMS INC/DE
S-8, 1996-08-15
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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<PAGE>
As filed with the Securities and Exchange Commission on August 15, 1996

                                            Registration No. 333-      
- -----------------------------------------------------------------------
- -----------------------------------------------------------------------

                    SECURITIES AND EXCHANGE COMMISSION
                         Washington, D.C.  20549
                        -------------------------

                                FORM S-8

                          REGISTRATION STATEMENT
                                  UNDER
                        THE SECURITIES ACT OF 1933

                        IMCLONE SYSTEMS INCORPORATED
          (Exact name of registrant as specified in its charter)

          Delaware                              04-2834797
(State or other jurisdiction of                (I.R.S. Employer
 incorporation or organization)                Identification No.)

                            180 Varick Street 
                        New York, New York  10014
   (Address of principal executive offices) (Zip code)

     ImClone Systems Incorporated 1996 Incentive Stock Option Plan
     ImClone Systems Incorporated 1996 Non-Qualified Stock Option Plan
                        (Full title of the plan)
                      -----------------------------
                            Harlan W. Waksal
            Executive Vice President and Chief Operating Officer
                       ImClone Systems Incorporated
                          180 Varick Street
                      New York, New York  10014
             (Name and address of agent for service)
                            (212) 645-1405
      (Telephone number, including area code, of agent for service)

                               Copy to:
                         Brian W. Pusch, Esq.
                     Law Offices of Brian W Pusch
                           29 West 57th Street
                            Penthouse Suite
                       New York, New York 10019

                    CALCULATION OF REGISTRATION FEE
- -----------------------------------------------------------------------
<TABLE>
<CAPTION>
                                   Proposed         Proposed            
Title of           Amount          maximum          maximum             Amount of
securities         to be           offering price   aggregate           registration
to be registered   registered (1)  per share (2)    offering price(2)   fee
- ------------------------------------------------------------------------------------
<S>                 <C>            <C>              <C>                 <C>
Common Stock,       1,850,000      $7.5625          $13,990,625         $4,825
$.001 par value     shares
</TABLE>
- ------------------------------------------------------------------------
(1)     Plus such additional indeterminate number of shares as may 
        be issuable pursuant to the anti-dilution provisions of the 
        Plan.

(2)     Estimated solely for the purpose of calculating the 
        registration fee.  Pursuant to Rule 457(c) and Rule 457(h) 
        under the Securities Act of 1933, as amended, the proposed 
        maximum offering price per share and the proposed maximum 
        aggregate offering price have been determined on the basis 
        of the average of the high and low prices of the Common 
        Stock on the National Association of Securities Dealers, 
        Inc. Automated Quotation/National Market System on August 9, 
        1996, as reported by The Wall Street Journal.
- ------------------------------------------------------------------------
- ------------------------------------------------------------------------

<PAGE>
                                PART I


           INFORMATION NOT REQUIRED IN THE REGISTRATION STATEMENT


ITEM 1.  PLAN INFORMATION.

ITEM 2.  REGISTRANT INFORMATION AND EMPLOYEE PLAN ANNUAL INFORMATION.


                                 I-1
<PAGE>
PART II


            INFORMATION REQUIRED IN THE REGISTRATION STATEMENT


ITEM 3.  INCORPORATION OF DOCUMENTS BY REFERENCE.

          The following documents which have heretofore been filed by 
ImClone Systems Incorporated, a Delaware corporation (the "Company"), 
with the Securities and Exchange Commission (the "Commission") pursuant 
to the Securities Exchange Act of 1934, as amended (the "Exchange Act"), 
are incorporated by reference herein and shall be deemed to be a part 
hereof:

          1.  The Company's Annual Report on Form 10-K for the 
     fiscal year ended December 31, 1995.

          2.  The Company's Quarterly Reports on Form 10-Q for the 
     fiscal quarters ended March 31, 1996 and June 30, 1996.

          3.  The Company's Current Reports on Form 8-K, dated 
     February 5, 1996 and February 14, 1996.

          4.  The description of the Company's Common Stock, par 
     value $.001 per share, contained in its Registration Statement on 
     Form 8-A filed under the Exchange Act, including any amendment or 
     report filed for the purpose of updating such description.

          All other documents filed by the Company with the Commission 
pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act 
subsequent to the date of this Registration Statement and prior to the 
filing of a post-effective amendment to this Registration Statement 
which indicates that all securities offered have been sold or which 
deregisters all securities then remaining unsold, shall be deemed to be 
incorporated by reference in this Registration Statement and to be a 
part hereof from the date of filing of such documents (such documents, 
and the documents enumerated above, being hereinafter referred to 
collectively as the "Incorporated Documents").

          Any statement contained in an Incorporated Document shall be 
deemed to be modified or superseded for purposes of this Registration 
Statement to the extent that a statement contained herein or in any 
other subsequently filed Incorporated Document modifies or supersedes 
such statement.  Any such statement so modified or superseded shall not 
be deemed, except as so modified or superseded, to constitute a part of 
this Registration Statement.


                                  II-1
<PAGE>
ITEM 4.  DESCRIPTION OF SECURITIES.

          Not applicable.

ITEM 5.  INTEREST OF NAMED EXPERTS AND COUNSEL.

          Not applicable.

ITEM 6.  INDEMNIFICATION OF DIRECTORS AND OFFICERS.

          The Company's Certificate of Incorporation sets forth the 
extent to which officers or directors of the Company may be indemnified 
against any liabilities which they may incur.  The general effect of 
such charter provision is that any person made a party to an action, 
suit or proceeding by reason of the fact that he is or was a director or 
officer of the Company, or of another corporation or other enterprise 
which he served as such at the request of the Company, shall be 
indemnified by the Company against expenses (including attorneys' fees, 
judgments, fines and amounts paid in settlement) reasonably incurred by 
him in connection with such action, suit or proceeding, to the full 
extent permitted under the laws of the State of Delaware.  The Company's 
Certificate of Incorporation gives the Board of Directors the authority 
to extend such indemnification to employees and other agents of the 
Company as well.

          The general effect of the indemnification provisions 
contained in Section 145 of the General Corporation Law of the State of 
Delaware (the "DGCL") is as follows:  A director or officer who, by 
reason of such directorship or officership, is involved in any action, 
suit or proceeding (other than an action by or in the right of the 
corporation) may be indemnified by the corporation against expenses 
(including attorney's fees), judgments, fines and amounts paid in 
settlement actually and reasonably incurred by him in connection with 
such action, suit  or proceeding if he acted in good faith and in a 
manner he reasonably believed to be in or not opposed to the best 
interests of the corporation, and, with respect to any criminal action 
or proceeding, had no reasonable cause to believe that his conduct was 
unlawful.  A director or officer who, by reason of such directorship or 
officership, is involved in any action or suit by or in the right of the 
corporation may be indemnified by the corporation against expenses 
(including attorneys' fees) actually and reasonably incurred by him in 
connection with the defense or settlement of such action or suit if he 
acted in good faith and in a manner he reasonably believed to be in or 
not opposed to the best interests of the corporation, except that no 
indemnification may be made in respect of any claim, issue or matter as 
to which he shall have been adjudged to be liable to the corporation 
unless and only to the extent that a court of appropriate jurisdiction 
shall approve such indemnification.

          The Company's Certificate of Incorporation provides that, to 
the maximum extent permitted under the DGCL, a director of the Company 
shall not be personally liable to the Company or to any of its 
stockholders for monetary damages for breach of fiduciary duty as a 
director of the Company.  Section 102(b)(7) of the DGCL permits a 
corporation to include in its certificate of incorporation a provision 
that eliminates or limits the personal liability of a director to the 
corporation or its stockholders for monetary damages for breach of 
fiduciary duty as a director, provided that such provision shall not 
eliminate or limit the liability of a director (i) for any breach of the 
director's duty of loyalty to the corporation or its stockholders, (ii) 
for acts or omissions not in good faith or which involve intentional 
misconduct or a knowing violation of law, (iii) under Section 174 of the 
DGCL or (iv) for any transaction from which the director derived an 
improper personal benefit.

          The Company maintains $2 million in insurance for its 
officers and directors in connection with claims against them in their 
capacity as officers or directors. 

                                  II-2
<PAGE>
ITEM 7.  EXEMPTION FROM REGISTRATION CLAIMED.

          Not applicable.

ITEM 8.  EXHIBITS.

<TABLE>
<CAPTION>
Exhibit
Number      Description
- -------     -----------
<C>         <S>
4.1         --Certificate of Incorporation of the Company, as amended, 
            (incorporated by reference to Exhibit No. 3.1 to the 
            Company's Registration Statement on Form S-1, File No. 33-
            43064)

4.2         --By-Laws of the Company (incorporated by reference to
            Exhibit No. 3.2 to the Company's Registration Statement on 
            Form S-1, File No. 33-43064)

5           --Opinion of Brian W. Pusch, Esq.

23.1        --Consent of KPMG Peat Marwick LLP

23.2        --Consent of Brian W. Pusch, Esq. (included in Exhibit 5)

24          --Power of Attorney (included on signature pages of this 
            Registration Statement)

99.1        --ImClone Systems Incorporated 1996 Incentive Stock Option 
            Plan (incorporated by reference to Exhibit A to the 
            definitive Proxy Statement for the 1996 Annual Meeting of 
            Stockholders, held on June 3, 1996, File No. 0-19612 (the 
            "1996 Proxy Statement"))

99.2        --Form of Incentive Stock Option Agreement relating to 
            options granted under the ImClone Systems Incorporated 1996 
            Incentive Stock Option Plan

99.3        --ImClone Systems Incorporated 1996 Non-Qualified Stock 
            Option Plan (incorporated by reference to Exhibit B to the 
            1996 Proxy Statement)

99.4        --Form of Non-Qualified Stock Option Agreement relating to 
            options granted under the ImClone Systems Incorporated 1996 
            Non-Qualified Stock Option Plan
</TABLE>

ITEM 9.  UNDERTAKINGS.

          (a)  The undersigned registrant hereby undertakes:

          (1)  to file, during any period in which offers or sales are 
     being made, a post-effective amendment to this Registration 
     Statement:

               (i)  to include any prospectus required by Section 
          10(a)(3) of the Securities Act of 1933;

               (ii)  to reflect in the prospectus any facts or events 
          arising after the effective date of this Registration 
          Statement (or the most recent post-effective amendment 
          thereof) which, individually or in the aggregate, represent 
          a fundamental change in the information set forth in this 
          Registration Statement.  Notwithstanding the foregoing, any 
          increase or decrease in volume of securities offered (if the 
          total dollar value of securities offered would not exceed 
          that which 

                                  II-3
<PAGE>
          was registered) and any deviation from the low or 
          high end of the estimated maximum offering range may be 
          reflected in the form of prospectus filed with the 
          Commission pursuant to Rule 424(b) if, in the aggregate, the 
          changes in volume and price represent no more than a 20% 
          change in the maximum aggregate offering price set forth in 
          the "Calculation of Registration Fee" table in the effective 
          registration statement;

               (iii)  to include any material information with 
          respect to the plan of distribution not previously disclosed 
          in this Registration Statement or any material change to 
          such information in this Registration Statement;

provided, however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply 
if the registration statement is on Form S-3, Form S-8 or Form F-3 and 
the information required to be included in a post-effective amendment by 
those paragraphs is contained in periodic reports filed with or 
furnished to the Commission by the registrant pursuant to Section 13 or 
Section 15(d) of the Securities Exchange Act of 1934 that are 
incorporated by reference in the registration statement;

          (2)  that, for the purpose of determining any liability 
     under the Securities Act of 1933, each such post-effective 
     amendment shall be deemed to be a new registration statement 
     relating to the securities offered therein, and the offering of 
     such securities at that time shall be deemed to be the initial 
     bona fide offering thereof; and

          (3)  to remove from registration by means of a post-
     effective amendment any of the securities being registered which 
     remain unsold at the termination of the offering.

          (b)  The undersigned registrant hereby undertakes that, for 
purposes of determining any liability under the Securities Act of 1933, 
each filing of the registrant's annual report pursuant to Section 13(a) 
or Section 15(d) of the Securities Exchange Act of 1934 (and, where 
applicable, each filing of an employee benefit plan's annual report 
pursuant to Section 15(d) of the Securities Exchange Act of 1934) that 
is incorporated by reference in the registration statement shall be 
deemed to be a new registration statement relating to the securities 
offered therein, and the offering of such securities at that time shall 
be deemed to be the initial bona fide offering thereof.

          (h)  Insofar as indemnification for liabilities arising 
under the Securities Act of 1933 may be permitted to directors, officers 
and controlling persons of the registrant pursuant to the foregoing 
provisions, or otherwise, the registrant has been advised that in the 
opinion of the Securities and Exchange Commission such indemnification 
is against public policy as expressed in the Act and is, therefore, 
unenforceable.  In the event that a claim for indemnification against 
such liabilities (other than the payment by the registrant of expenses 
incurred or paid by a director, officer or controlling person of the 
registrant in the successful defense of any action, suit or proceeding) 
is asserted by such director, officer or controlling person in 
connection with the securities being registered, the registrant will, 
unless in the opinion of its counsel the matter has been settled by 
controlling precedent, submit to a court of appropriate jurisdiction the 
question whether such indemnification by it is against public policy as 
expressed in the Act and will be governed by the final adjudication of 
such issue.

                                  II-4
<PAGE>
                               SIGNATURES

          Pursuant to the requirements of the Securities Act of 1933, 
the Registrant certifies that it has reasonable grounds to believe that 
it meets all of the requirements for filing on Form S-8 and has duly 
caused this Registration Statement to be signed on its behalf by the 
undersigned, thereunto duly authorized, in the City of New York, State 
of New York, on the 15th day of August, 1996.

                                   IMCLONE SYSTEMS INCORPORATED



                                   By:  /s/ SAMUEL D. WAKSAL
                                            Samuel D. Waksal
                                      President and Chief Executive 
                                                Officer


          Pursuant to the requirements of the Securities Act of 1933, 
this Registration Statement has been signed below by the following 
persons in the capacities and on the dates indicated.  Each person whose 
individual signature appears below hereby authorizes Samuel D. Waksal, 
Harlan W. Waksal and John B. Landes, or any one of them, to execute in 
the name of each such person and to file any amendment to this 
Registration Statement and appoints Samuel D. Waksal, Harlan W. Waksal 
and John B. Landes, or any one of them, as attorney-in-fact to sign on 
his behalf individually and in each capacity stated below and to file 
any amendments to this Registration Statement, including any and all 
post-effective amendments.

Signature                    Title                         Date
- ---------                    -----                         ----


/s/ ROBERT F. GOLDHAMMER   Chairman of the Board         August 6, 1996
(Robert F.Goldhammer)      and Director     


/s/ SAMUEL D. WAKSAL       President, Chief Executive    August 15, 1996
(Samuel D. Waksal)         Officer and Director
                           (Principal Executive Officer)


/s/ HARLAN W. WAKSAL       Executive Vice President,     August 15, 1996
(Harlan W. Waksal)         Chief Operating Officer
                           and Director     

                                  II-5
<PAGE>


/s/ DR. CARL GOLDFISCHER   Vice President of Financial   August 15, 1996
(Dr. Carl Goldfischer)     and Strategic Planning and 
                           Chief Financial Officer
                           (Principal Financial Officer)


/s/ JEAN CARVAIS           Director                      August 15, 1996
(Jean Carvais)


/s/ VINCENT T. DEVITA, JR  Director                      August 15, 1996
(Vincent T.DeVita, Jr.)     


/s/ PAUL B. KOPPERL        Director                      August 15, 1996
(Paul B. Kopperl)     


/s/ WILLIAM R. MILLER      Director                      August 15, 1996
(William R. Miller)     


/s/ DAVID M. KIES          Director                      August 15, 1996
(David M. Kies)     

                                  II-6
<PAGE>
                              EXHIBIT INDEX

<TABLE>
<CAPTION>
EXHIBIT
NUMBER      DESCRIPTION
- -------     -----------
<C>         <S>
4.1         --Certificate of Incorporation of the Company, as amended, 
            (incorporated by reference to Exhibit No. 3.1 to the 
            Company's Registration Statement on Form S-1, File No. 33-
            43064)

4.2         --By-Laws of the Company (incorporated by reference to
            Exhibit No. 3.2 to the Company's Registration Statement on 
            Form S-1, File No. 33-43064)

5           --Opinion of Brian W. Pusch, Esq.

23.1        --Consent of KPMG Peat Marwick LLP

23.2        --Consent of Brian W. Pusch, Esq. (included in Exhibit 5)

24          --Power of Attorney (included on signature pages of this 
            Registration Statement)

99.1        --ImClone Systems Incorporated 1996 Incentive Stock Option 
            Plan (incorporated by reference to Exhibit A to the 
            definitive Proxy Statement for the 1996 Annual Meeting of 
            Stockholders, held on June 3, 1996, File No. 0-19612 (the 
            "1996 Proxy Statement"))

99.2        --Form of Incentive Stock Option Agreement relating to 
            options granted under the ImClone Systems Incorporated 1996 
            Incentive Stock Option Plan

99.3        --ImClone Systems Incorporated 1996 Non-Qualified Stock 
            Option Plan (incorporated by reference to Exhibit B to the 
            1996 Proxy Statement)

99.4        --Form of Non-Qualified Stock Option Agreement relating to 
            options granted under the ImClone Systems Incorporated 1996 
            Non-Qualified Stock Option Plan
</TABLE>


<PAGE>
                                                              EXHIBIT 5
                            LAW OFFICES OF 
                            BRIAN W PUSCH
                           ATTORNEYS AT LAW

                            PENTHOUSE SUITE
                          29 WEST 57TH STREET
                           NEW YORK, NY 10019
                       TELEPHONE   (212) 980-0408
                       FACSIMILE   (212) 980-7055

                                    August 15, 1996

ImClone Systems Incorporated
180 Varick Street
New York, New York 10014

                       IMCLONE SYSTEMS INCORPORATED
                           1,850,000 Shares
                       Common Stock, $.001 par value
                     Registration Statement on Form S-8
                     ----------------------------------

Ladies and Gentlemen:

          I am acting as special counsel to ImClone Systems 
Incorporated, a Delaware corporation (the "Company"), in connection with 
the filing by the Company with the Securities and Exchange Commission 
pursuant to the Securities Act of 1933, as amended (the "Securities 
Act"), of a registration statement on Form S-8 (the "Registration 
Statement") relating to an aggregate of 1,850,000 shares (the "Shares") 
of the Company's Common Stock, par value $.001 per share, which may be 
purchased by the holders of options granted pursuant to the ImClone 
Systems Incorporated 1996 Incentive Stock Option Plan and the ImClone 
Systems Incorporated 1996 Non-Qualified Stock Option Plan (collectively, 
the "Plans") and by the holders of certain warrants of the Company 
issued to certain employees, consultants, officers and directors of the 
Company (collectively, the "Warrants").

          This opinion is being furnished pursuant to the requirements 
applicable to Item 8 of Part II of the Registration Statement.

          In connection with this opinion, I have examined and relied 
on originals or copies, certified or otherwise identified to my 
satisfaction, of such corporate records, documents, agreements or other 
instruments of the Company and its subsidiaries, orders, rulings and 
certificates of public officials, officers and representatives of the 
Company and its subsidiaries and such other persons, have made 
investigations of law, and have discussed with officers and other 
representatives of the Company and its subsidiaries such questions of 
fact, as I have

<PAGE>
ImClone Systems Incorporated
August 15, 1996
Page 2


deemed proper and necessary as a basis for the opinions 
hereinafter expressed.

          In my examination, I have assumed the genuineness of all 
signatures, the legal capacity of all natural persons, the authenticity 
of all documents submitted to me as originals, the conformity to 
original documents of all documents submitted to me as certified or 
photostatic copies and the authenticity of the originals of such latter 
documents.  As to any facts material to the opinions expressed herein 
which were not independently established or verified, I have relied upon 
statements and representations of officers and other representatives of 
the Company and others.

          I do not purport to express an opinion herein concerning any 
laws other than the laws of the State of New York and the General 
Corporation Law of the State of Delaware.

          Based upon and subject to the foregoing, I am of the opinion 
that the Shares are duly authorized and that (1) when the Registration 
Statement shall have become effective, (2) when the provisions of the 
securities and blue sky laws of certain jurisdictions shall have been 
complied with and (3) when the Shares, certificates for which shall have 
been duly executed, shall have been duly delivered against payment of 
the consideration therefor in accordance with the Plans or the Warrants, 
as the case may be, the Shares will be legally issued and fully-paid and 
non-assessable under the laws of the State of Delaware.

          I hereby consent to the filing of this opinion as an exhibit 
to the Registration Statement.  In giving such consent, I do not thereby 
admit that I  am in the category of persons whose consent is required 
under Section 7 of the Securities Act.

                                    Very truly yours,


                                    /s/ BRIAN W. PUSCH
                                    Brian W. Pusch

BWP:pb


                                                           EXHIBIT 23.1



                        INDEPENDENT AUDITORS' CONSENT


The Board of Directors
ImClone Systems Incorporated

We consent to the use of our report incorporated herein by reference.


                                    KPMG PEAT MARWICK LLP


August 15, 1996






<PAGE>
                                                         Option #000---

                       IMCLONE SYSTEMS INCORPORATED

                            STOCK OPTION UNDER

                      1996 INCENTIVE STOCK OPTION PLAN


     1.  This Stock Option for a total of ______shares of Common 
Stock of ImClone Systems Incorporated, a Delaware corporation (the 
"Company"), is hereby granted to __________ (the "Optionee") at the 
price determined as provided in, and in all respects subject to the 
terms and provisions of, the 1996 Incentive Stock Option Plan (the 
"Plan") adopted by the Company as amended, which is incorporated by 
reference herein.  This Option is intended to qualify as an incentive 
stock option under section 422 of the Internal Revenue Code of 1986, as 
amended.

     2.  The option price is $_____ per share, being 100% of the 
fair market value, as determined by the Stock Option Committee, of the 
Common Stock on the Date of Grant of this Option.

     3.  This Option may not be exercised if the grant of this Option 
or the issuance of shares upon the exercise thereof would constitute a 
violation of any applicable Federal or State securities law, or any 
other law or governmental regulation.  As a condition to the Optionee's 
exercise of this Option, the Company may require the person exercising 
this Option to make any representation and warranty to the Company as 
may be required by any applicable law or regulation.

     4.  This Option may not be transferred in any manner otherwise 
than by will or the laws of descent or distribution, or pursuant to a 
qualified domestic relations order ("QDRO") as defined by the Internal 
Revenue Code of 1986, as amended, or Title I of the Employee Retirement 
Income Security Act of 1974, as amended, or the rules thereunder.  
During the Participant's lifetime, options shall be exercised only by 
such Participant, such Participant's guardian or legal representative, 
or such Participant's transferee pursuant to a QDRO.  The terms of this 
Option shall be blinding upon the executors, administrators, heirs, 
successors and assigns of the Optionee.

     5.  This Option shall be exercisable cumulatively, subject to 
the provisions of the Plan, as follows:

          (a)  25% of the shares on or after each of the first, 
second, third and fourth anniversaries of the Date of the Grant.

<PAGE>
     6.  This Option may not be exercised more than ten years from 
the date of grant of this Option, as set forth below, and may be 
exercised during such term only in accordance with the Plan and the 
terms of this Option.

     7.  By acceptance of this Option, the holder of this Option 
agrees, on behalf of the holder and such holder's heirs, executors, 
administrators and assigns that, in connection with any underwritten 
public offering of shares of Common Stock, the holder and the holder's 
heirs, executors, administrators and assigns will enter into such 
restrictions on the sale or transfer of the shares of Common Stock 
issuable upon exercise of this Option as the Company and any 
underwriter(s) for such offering may reasonably request in order to 
facilitate the offer, sale and distribution of securities of the Company 
in connection with such offering, whether or not this option has been 
exercised at the time of such offering.

                                   ImClone Systems Incorporated


                                   ____________________________

Date of Grant:


Attest:  _________________

<PAGE>
     Optionee acknowledges receipt of a copy of this Plan, a copy of 
which is annexed hereto, and represents that he/she is familiar with the 
terms and provisions thereof, and hereby accepts this Option, subject to 
all the terms and provisions thereof, except as otherwise stated in the 
Option.  Optionee hereby agrees to accept as binding, conclusive and 
final all decisions or interpretations of the Stock Option Committee, or 
Board of Directors, as applicable upon any questions arising under the 
Plan.


                                    _________________________
                                            Optionee 


Optionee Name (Print):
IncentiveStock Option No:
Date:


<PAGE>
                                                       Option # N0000--
                      IMCLONE SYSTEMS INCORPORATED
                           STOCK OPTION UNDER
                   1996 NON-QUALIFIED STOCK OPTION PLAN

     1.  This Stock Option for a total of ------- shares of 
Common Stock of ImClone Systems Incorporated, a Delaware corporation 
(the "Company"), is hereby granted to ---------- (the "Optionee") at 
the price determined as provided in, and in all respects subject to the 
terms and provisions of, the 1996 Non-Qualified Stock Option Plan (the 
"Plan") adopted by the Company, which is incorporated by reference 
herein.
     2.  The option price is $----- per share.
     3.  This Option may not be exercised if the grant of this 
Option or the issuance of shares upon the exercise thereof would 
constitute a violation of any applicable Federal or State securities 
law, or any other law or governmental regulation.  As a condition to the 
exercise of this Option, the Company may require the person exercising 
this Option to make any representation and warranty to the Company as 
may be required be any applicable law or regulation.
     4.  This Option may not be transferred in any manner 
otherwise than by will or the laws of descent or distribution, or 
pursuant to a qualified domestic relations order ("QDRO") as defined by 
the Internal Revenue Code of 1986, as amended, or Title I of the 
Employee Retirement Income Security Act of 1974, as amended, or the 
rules thereunder.  During the Participant's lifetime, options shall be 
exercised only by such Participant, such Participant's guardian or legal 
representative, or such Participant's transferee pursuant to a QDRO.  
The terms of this Option shall be binding upon the executors, 
administrators, heirs, successors and assigns of the Optionee.
     5.  This Option shall be exercisable cumulatively, subject to 
the provisions of the Plan, as follows:
          (a)     25% of the shares on or after each of the first, 
second, third and fourth anniversaries of the date of grant.

<PAGE>
     6. This Option may not be exercised more than ten years from 
the date of grant of this Option, as set forth below, and may be 
exercised during such term only in accordance with the Plan and the 
terms of this Option.
     7.  By acceptance of this Option, the holder of this Option 
agrees, on behalf of the holder and such holder's heirs, executors, 
administrators and assigns that, in connection with any underwritten 
public offering of shares of Common Stock, the holder and the holder's 
heirs, executors, administrators and assigns will enter into such 
restrictions on the sale or transfer of the shares of Common Stock 
issuable upon exercise of this Option as the Company and any 
underwriter(s) for such offering may reasonably request in order to 
facilitate the offer, sale and distribution of securities of the Company  
in connection with such offering, whether or not this option has been 
exercised at the time of such offering.

                                   ImClone Systems Incorporated 

                              
                                   By:__________________________

Date of Grant:  Attest:____________________

<PAGE>
     Optionee acknowledges receipt of a copy of this Plan, a copy of 
which is annexed hereto, and represents that he/she is familiar with the 
terms and provisions thereof, and hereby accepts this Option, subject to 
all the terms and provisions thereof, except as otherwise stated in the 
Option.  Optionee hereby agrees to accept as binding, conclusive and 
final all decisions or interpretations of the Stock Option Committee, or 
Board of Directors, as applicable upon any questions arising under the 
Plan.


                                   
     _________________________
                                        Optionee 


Optionee Name:
Non-Qualified Stock Option No:
Date:______________




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