IMCLONE SYSTEMS INC/DE
PRE 14A, 1997-04-09
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                            SCHEDULE 14A INFORMATION
Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934
                               (Amendment No. __ )

Filed by the Registrant [x] 

Filed by a Party other than the Registrant [ ] 

Check the appropriate box: 
[x] Preliminary Proxy Statement 
[ ] Confidential, for Use of the Commission Only (as permitted by 
    Rule 14a-6(e)(2)) 
[ ] Definitive Proxy Statement 
[ ] Definitive  Additional  Materials 
[ ] Soliciting Material Pursuant to ss.240.14a-11(c) or ss.240.14a-12 

                          ImClone Systems Incorporated
                (Name of Registrant as Specified In Its Charter)

- --------------------------------------------------------------------------------
     (Name of Person(s) Filing Proxy Statement if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):
[x]  No fee Required.
[  ]  Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.

       1) Title of each class of securities to which transaction applies:

       ------------------------------------------------------------------------

       2) Aggregate number of securities to which transaction applies:

       ------------------------------------------------------------------------

       3) Per unit  price  or other  underlying  value of  transaction  computed
pursuant to Exchange Act Rule 0-11 (Set forth the amount on which the filing fee
is calculated and state how it was determined):

       ------------------------------------------------------------------------

       4) Proposed maximum aggregate value of transaction:

       ------------------------------------------------------------------------

       5) Total fee paid:

       ------------------------------------------------------------------------

[ ] Fee paid previously with preliminary materials.

[ ] Check box if any part of the fee is offset as provided by Exchange  Act Rule
0-11(a)(2)  and  identify  the  filing  for  which the  offsetting  fee was paid
previously.  Identify the previous filing by registration  statement  number, or
the Form or Schedule and the date of its filing

       1) Amount previously paid:

       ---------------------------------------------------

       2) Form, Schedule or Registration Statement No.:

       ---------------------------------------------------

       3) Filing Party:

       ---------------------------------------------------

       4) Date Filed:

       ---------------------------------------------------

<PAGE>

                                                              PRELIMINARY COPIES

                          IMCLONE SYSTEMS INCORPORATED

                                180 Varick Street

                               New York, NY 10014

                          ----------------------------

        NOTICE OF ANNUAL MEETING OF STOCKHOLDERS TO BE HELD JUNE 3, 1997

                          ----------------------------



To The Stockholders of ImClone Systems Incorporated:

     Notice is  hereby  given  that the  Annual  Meeting  of  Stockholders  (the
"Meeting") of ImClone Systems Incorporated (the "Company") will be held at 10:00
a.m.,  local time,  on  Tuesday,  June 3, 1997 at the  Company's  offices at 180
Varick  Street,  Seventh  Floor,  New York,  New York 10014,  for the  following
purposes:

     1.   To elect nine directors.

     2.   To  consider  and vote upon a  proposal  to amend the  Company's  1996
          Incentive  Stock Option Plan (the "1996 ISO Plan") to (i) increase the
          total number of shares of the Company's common stock,  $.001 par value
          (the "Common Stock") which may be issued pursuant to options which may
          be granted under the 1996 ISO Plan from 1,500,000 to 3,000,000,  which
          number  shall be reduced by the number of shares of Common Stock which
          have been or may be  issued  pursuant  to  options  granted  under the
          Company's   1996   Non-Qualified   Stock   Option   Plan  (the   "1996
          Non-Qualified  Plan");  and (ii) provide that any of the  Compensation
          Committee,  the Stock Option  Committee or the Board of Directors (the
          "Board") may  administer  the 1996 ISO Plan and that such persons need
          not be  "disinterested  persons" as such term was formerly  defined in
          Rule 16b-3 promulgated under section 16(b) of the Securities  Exchange
          Act of 1934, as amended (the "Exchange Act").

     3.   To  consider  and vote upon a  proposal  to amend the  Company's  1996
          Non-Qualified  Plan to (i)  increase  the  total  number  of shares of
          Common  Stock  which may be issued  pursuant  to options  which may be
          granted under the 1996 Non-Qualified Plan from 1,500,000 to 3,000,000,
          which  number shall be reduced by the number of shares of Common Stock
          which have been or may be issued pursuant to options granted under the
          1996 ISO Plan;  (ii) provide that any of the  Compensation  Committee,
          the  Stock  Option  Committee  or the Board  may  administer  the 1996
          Non-Qualified  Stock  Option  Plan and that such  persons  need not be
          "disinterested  persons"  as such term was  formerly  defined  in Rule
          16b-3  promulgated  under the Exchange Act; (iii) provide that members
          of the Board or any  committee  administering  the 1996  Non-Qualified
          Plan  are  eligible  to  receive   discretionary   grants  of  options
          thereunder; and (iv) clarify that key consultants and employees of the
          Company are eligible to participate in the 1996  Non-Qualified Plan in
          addition to key advisors and directors.


<PAGE>

     4.   To  consider  and  vote  upon  a  proposal  to  amend  the   Company's
          Certificate of Incorporation to increase the total number of shares of
          Common Stock the Company is authorized to issue from 30,000,000 shares
          to 45,000,000 shares.

     5.   To  ratify  the  appointment  by the Board of  Directors  of KPMG Peat
          Marwick LLP as the Company's  independent certified public accountants
          for the fiscal year ending December 31, 1997.

     6.   To  consider  and act upon such other  business as may  properly  come
          before the Meeting or any adjournment thereof.

     Only holders of Common Stock of record at the close of business on April 7,
1997 are  entitled  to notice of and to vote at the  Meeting or any  adjournment
thereof.

                                        By Order of the Board of Directors



New York, NY                            JOHN B. LANDES
April ___, 1997                         Secretary
 

Whether or not you expect to attend the Meeting,  please complete, sign and date
the  enclosed  proxy and  promptly  return it in the  envelope  provided  to the
Company's  transfer  agent,  Boston  EquiServe,  150  Royall  Street,  Mail Stop
45-02-62,  Canton, MA 02021, to be received no later than May 30, 1997. In order
to avoid the additional expense to the Company of further  solicitation,  we ask
your  cooperation in sending in your proxy promptly.  Sending in your proxy will
not prevent you from voting in person at the Annual Meeting.


<PAGE>

                          IMCLONE SYSTEMS INCORPORATED

                                180 Varick Street

                            New York, New York 10014

                       ----------------------------------

                                 PROXY STATEMENT

                       ----------------------------------

     This proxy  statement is furnished in connection  with the  solicitation of
proxies  for use at the  Annual  Meeting  of  Stockholders  of  ImClone  Systems
Incorporated  (the "Company") to be held at 10:00 a.m.,  local time, on Tuesday,
June 3, 1997 at the Company's  principal executive offices at 180 Varick Street,
Seventh Floor, New York, New York 10014,  and at any  adjournments  thereof (the
"Meeting"). The accompanying proxy is solicited by the Board of Directors of the
Company ("the Board") and is revocable by the stockholders any time before it is
voted. The purpose of the Meeting and the matters to be acted upon are set forth
in the accompanying Notice of Annual Meeting of Stockholders.

                      OUTSTANDING SHARES AND VOTING RIGHTS

     The close of  business  on April 7, 1997 has been fixed as the record  date
(the "Record Date") for the determination of stockholders entitled to notice of,
and to vote at, the Meeting. On April 7, 1997, the Company had 23,693,199 shares
of common stock, par value $.001 per share (the "Common Stock"), outstanding and
entitled to vote.  Such shares of Common Stock are the only  outstanding  voting
securities of the Company.  Each share held of record on the Record Date will be
entitled to one vote at the Meeting.  There are no cumulative  voting rights. It
is expected that the Notice of Annual Meeting, Proxy Statement and form of proxy
will first be mailed to stockholders on or about April 25, 1997.

     To be elected as a director under Proposal No. 1, a director must receive a
plurality  of the  votes of the  shares  of Common  Stock  present  in person or
represented  by proxy at the  Meeting and  entitled  to vote on the  election of
directors.  The  affirmative  vote of a majority  of the shares of Common  Stock
outstanding on the Record Date, present in person or represented by proxy at the
Meeting and entitled to vote thereon, is necessary for approval of Proposal Nos.
2, 3 and 5. The  affirmative  vote of a majority  of the shares of Common  Stock
outstanding  on the Record Date is  necessary  for approval of Proposal No. 4. A
quorum is  representation  in person  or by proxy at the  Meeting  of at least a
majority of the shares of Common Stock outstanding on the Record Date.

     Pursuant to the Delaware  General  Corporation Law, only votes cast "For" a
matter  constitute  affirmative  votes.  Proxies  which  are  voted  by  marking
"Withheld" or "Abstain" on a particular matter are counted as present for quorum
purposes and for purposes of determining  the outcome of such matter,  but since
they are not cast "For" a particular  matter,  they will have the same effect as
negative votes or votes  "Against" a particular  matter.  If a validly  executed
proxy card is not marked to indicate a vote on a particular matter and the proxy
granted  thereby is not revoked before it is voted,  it will be voted "For" such
matter. Where brokers are prohibited from exercising discretionary authority for
beneficial owners who have not provided voting  instructions  (commonly referred
to as "broker non-votes"),  such broker non-votes will be treated as shares that
are present for purposes of determining the presence of a quorum;  however, with
respect to proposals which require the affirmative vote of a percentage of votes
present at the Meeting for approval,  such broker  non-votes  will be treated as
not present for purposes of determining the outcome of any such matter,  thereby
reducing  the number of  affirmative  votes  required  for the  approval of such
matter.  With  respect to  proposals  which  require the  affirmative  vote of a
percentage of the outstanding shares for approval, because such broker non-votes
are not cast  "For" a  particular  matter,  they  will  have the same  effect as
negative votes or votes "Against" such proposals.  The Board knows of no matters
which are to be  presented  for  consideration  at the Meeting  other than those
specifically described in the Notice of Annual Meeting of Stockholders,  but, if
other  matters  are  properly  presented,  it is the  intention  of the  persons
designated as proxies to vote on them in accordance with their judgment.

<PAGE>

                                 PROPOSAL NO. 1

                         ELECTION OF BOARD OF DIRECTORS

     It is proposed  that the nine  nominees  named below will be elected at the
Meeting to serve as  directors  of the Company  for  one-year  terms.  It is the
intention  of the persons  named in the  accompanying  proxy,  unless  otherwise
instructed,  to vote  for the  nominees  named  herein.  All  such  persons  are
currently members of the Board of Directors (the "Board"). No proxy may be voted
for more  persons  than the number of nominees  listed  below.  The Board has no
reason to believe that any of the  nominees  will become  unavailable  to serve,
but, if that should  occur  before the  Meeting,  proxies will be voted for such
other persons as the Board may nominate.  The nominees for election as director,
and certain information with respect to their ages and backgrounds are set forth
below.

                              Nominees For Director

<TABLE>
<CAPTION>

Name                                        Age      Current Position with Company        Director of Company Since
- ----                                        ---      -----------------------------        -------------------------
<S>                                         <C>      <C>                                            <C>  
Richard Barth (1)(2)                        65       Director                                       1996
Jean Carvais, M.D.                          70       Director                                       1993
Vincent T. DeVita, Jr., M.D. (2)(3)         62       Director                                       1992
Robert F. Goldhammer (2)(3)(4)(5)           66       Chairman of the Board                          1984
David M. Kies (1)(5)                        53       Director                                       1996
Paul B. Kopperl (1)(2)(5)                   63       Director                                       1993
William R. Miller (1)(5)                    68       Director                                       1996
Harlan W. Waksal, M.D. (4)(5)               44       Executive Vice President,                     
                                                     Chief Operating Officer and Director           1984
Samuel D. Waksal, Ph.D. (4)                 49       President, Chief Executive Officer            
                                                     and Director                                   1985
</TABLE>

(1)  Member of Audit Committee
(2)  Member of Compensation Committee
(3)  Member  of Stock  Option  Committee  (a  subcommittee  of the  Compensation
     Committee)
(4)  Member of Executive Committee
(5)  Member of Corporate Governance Committee

                        BUSINESS EXPERIENCE OF DIRECTORS

     Richard  Barth,  has been a director of the Company since October 1996. Mr.
Barth served as Chairman of the Board of Ciba-Geigy  Corporation,  United States
("Ciba-Geigy") from 1990 until December 1996, at which time he retired,  and was
President and Chief  Executive  Officer of  Ciba-Geigy  from 1986 until 1996. He
joined the Ciba  Corporation  in 1965 as legal  assistant to the executive  vice
president,  serving in that capacity until 1968, when he was named Secretary and
General  Counsel.  Following  the merger of Ciba and  Geigy,  Mr.  Barth  became
General Counsel of the  corporation.  In 1974, he was named Corporate  Secretary
and,  in 1975,  he  became a member  of the  Board of  Directors.  In 1979,  his
responsibilities  were further  broadened to include  serving as Chief Financial
Officer and  Chairman of the Board's  Finance  Committee.  Mr.  Barth also was a
Senior Vice President of Ciba-Geigy  from 1980 until 1986. Mr. Barth is a member
of the Board of Directors of numerous corporations and organizations,  including
The Bank of New York and Bowater,  Inc.,  and serves as Chairman of the Board of
Trustees of New York Medical College.


                                       2
<PAGE>

     Jean Carvais, M.D., has been a director since July 1993, and has since 1984
been an  independent  consultant  to companies in the  pharmaceutical  industry.
Prior to that time, Dr. Carvais was President of The Research Institute of Roger
Bellon, S.A., now a division of Rhone-Poulenc Rorer, Inc. ("Rhone-Poulenc").  As
such,  he was  involved  in the  development  of a line  of  anti-cancer  drugs,
including  Bleomycin and  Adriamycin,  as well as a new line of antibiotics  and
quinolones.  Following the acquisition of Roger Bollon,  S.A. by  Rhone-Poulenc,
Dr. Carvais became a member of Rhone-Poulenc's  central research committee which
directs the company's worldwide research and development activities. Dr. Carvais
is a director of Columbia Laboratories, Inc.

     Vincent T. DeVita,  Jr., M.D., has been a director since February 1992. Dr.
DeVita is Director of the Yale Cancer  Center as well as  Professor  of Medicine
and Professor of  Epidemiology  and Public Health at Yale  University  School of
Medicine,  New Haven,  Connecticut.  From  September 1988 through June 1995, Dr.
DeVita served as Attending Physician at Memorial  Sloan-Kettering Cancer Center,
New York,  New York, and through June 1991 as  Physician-in-Chief.  From 1980 to
1988,  he served  under  Presidential  appointment  as Director of the  National
Cancer Institute ("NCI"), where he had held various positions since 1966. During
his years with the NCI, Dr.  DeVita was  instrumental  in  developing  the first
successful  combination cancer chemotherapy program. This work ultimately led to
effective  regimes  of  curative  chemotherapy  for a variety  of  cancers.  Dr.
DeVita's  numerous  awards  include the 1990 Armand  Hammer Cancer Prize and the
1982 Albert and Mary Lasker Medical  Research Award for his  contribution to the
cure of  Hodgkin's  disease.  Dr.  DeVita  received  his M.D.  from  the  George
Washington University School of Medicine, Washington, DC, in 1961.

     Robert F. Goldhammer,  has served as the Company's Chairman of the Board of
Directors  since  February  1991 and as Chairman of the  Compensation  Committee
since September 1991. From March 1987 to February 1991, Mr. Goldhammer served as
Chairman of the  Executive  Committee of the Company.  He has been a Director of
the Company  since October 1984.  Mr.  Goldhammer  has been a partner of Concord
International  Investment  Group,  L.P. since 1991. He was a partner of Rohammer
Corporation,  a private investment company, from 1989 to 1991. He was a managing
director of Kidder,  Peabody Group Inc., an  investment  banking firm,  from May
1988  to  January  1989.  He  is  a  director  of  E.G.&G,  Inc.  and  Esterline
Technologies Corporation.

     David M. Kies, has been a director of the Company since June 1996. Mr. Kies
is a Partner of the New York based law firm Sullivan & Cromwell, specializing in
mergers and  acquisitions,  securities and general corporate  matters.  Mr. Kies
joined  Sullivan & Cromwell  in 1968,  and was  elected a partner of the firm in
1976.  From 1991 until 1995,  he was the managing  partner of the firm's  London
office,  the largest office of U.S.  lawyers in London and the largest office of
U.S.  securities  lawyers in Europe.  He has had  extensive  experience  in many
complex international and U.S. financial transactions,  principally representing
non-U.S. entities or their financial advisors.

     Paul B. Kopperl, has served on the Board since December 1993. He has served
as President of Delano & Kopperl,  Inc., a financial advisory firm in Boston and
its  predecessor  firms from 1976 to the present.  From 1967 through 1975 he was
Vice  President  and a  principal  of  Kidder,  Peabody & Co.  Incorporated,  an
investment  banking  firm.  From 1959 to 1967 he was an associate  with Goldman,
Sachs & Co., of New York. He is President of Pegasus Investments,  Inc., Boston,
a private investment management firm. Over the years Mr. Kopperl has served as a
trustee  of  numerous  not-for-profit  educational,  performing  arts and social
welfare organizations.

     William R. Miller,  has been a director of the Company since June 1996. Mr.
Miller  served as Vice  Chairman of the Board of Directors of the  Bristol-Myers
Squibb  Company from 1985 until 1991, at which time he retired.  Mr. Miller is a
director of Isis Pharmaceuticals,  Inc., St. Jude Medical,  Inc.,  Transkaryotic
Therapies,  Inc., Westvaco  Corporation and Xomed Surgical Products,  Inc. He is
Chairman of the Board of Vion  Pharmaceuticals,  Inc.  and SIBIA  Neurosciences,
Inc. He is Vice  Chairman  of the Board of  Trustees  of the Cold Spring  Harbor
Laboratory  and  is  a  past  Chairman  of  the  Board  of  the   Pharmaceutical
Manufacturers  Association.  Mr. Miller is a Trustee of the Manhattan  School of
Music,  Metropolitan  Opera Association and Opera Orchestra of New York. He is a
member of Oxford University  Chancellor's Court of Benefactors;  Honorary Fellow
of St.  Edmund  Hall and  Chairman of the  English-Speaking  Union of the United
States.


                                       3
<PAGE>

     Harlan W. Waksal, M.D., is a founder of the Company and has been a director
since April 1984. He has directed the Company's  research and development  since
April 1985,  and has served as the Company's  Executive Vice President and Chief
Operating  Officer since March 1987.  From 1985 to March 1987, Dr. Waksal served
as the  Company's  President.  Dr.  Waksal  received  his  training  in Internal
Medicine from Tufts-New  England  Medical Center  Hospital and in Pathology from
Kings  County  Hospital in  Brooklyn,  New York from 1982 to 1987.  From 1984 to
1985,  Dr. Waksal was Chief Resident in Pathology at Kings County  Hospital.  He
received his Medical Degree from Tufts University School of Medicine in 1979. He
is  currently  Adjunct  Assistant  Professor in the  Department  of Pathology at
Downstate Medical Center,  New York. Dr. Harlan Waksal and Dr. Samuel Waksal are
brothers.

     Samuel D. Waksal,  Ph.D.,  President  of the  Company,  is a founder of the
Company and has been its Chief  Executive  Officer and a director  since  August
1985 and  President  since  March  1987.  Dr.  Waksal has been  Chairman  of the
Company's  Executive  Committee  since  September  1991.  From 1982 to 1985, Dr.
Waksal was a member of the faculty of Mt.  Sinai School of Medicine as Associate
Professor of Pathology and Director of the Division of Immunotherapy  within the
Department of Pathology.  He has served as visiting Investigator of the National
Cancer Institute,  Immunology  Branch,  Research  Associate of the Department of
Genetics,  Stanford University Medical School,  Assistant Professor of Pathology
at Tufts University School of Medicine and Senior Scientist for the Tufts Cancer
Research  Center.  Dr.  Waksal was a scholar of the Leukemia  Society of America
from 1979 to 1984. Dr. Waksal currently serves on the Executive Committee of the
New York  Biotechnology  Association  and on the Board of  Directors  of each of
Cadus Pharmaceutical Corporation and Somatix Therapy Corp. Dr. Samuel Waksal and
Dr. Harlan Waksal are brothers.

     All  directors of the Company hold office until the next Annual  Meeting of
Stockholders and until their successors have been duly elected and qualified.

     The  Board  recommends  a vote  "FOR"  each  of the  nominees  named  above
(Proposal No. 1 on the proxy card).

                             DIRECTORS' COMPENSATION

     Each  director  of the Company who is not an employee of the Company or who
does  not  otherwise  provide  consulting   services  to  the  Company  receives
compensation  of $10,000 per year, or a pro rata portion thereof for persons not
serving the full fiscal year,  for such person's  services as a director as well
as reimbursement of the director's reasonable out-of-pocket expenses incurred in
connection with his Board and Board committee activities.  In addition,  subject
to the  preceding  sentence,  the  Chairman  of  each  of the  Audit  Committee,
Compensation  Committee and Corporate  Governance  Committee receives $5,000 per
year as compensation for the services of each as Chairman. Because the Corporate
Governance  Committee did not meet during the 1996 fiscal year, its Chairman did
not receive  such $5,000  payment for 1996.  Pursuant to the 1996  Non-Qualified
Plan, non-full-time employee directors also receive each February 15th an option
to purchase 2,500 shares of Common Stock which vests only after one full year of
service on the Board from the date of grant.  The Company  maintains  and is the
beneficiary  under  key-man  insurance  coverage of  $6,000,000  for each of Dr.
Samuel D. Waksal and Dr. Harlan W. Waksal.  Dr. DeVita received  $100,000 during
the  year  ended  December  31,  1996 in  consideration  for his  services  as a
consultant to the Company.

                   INFORMATION CONCERNING BOARD AND COMMITTEE
                      MEETINGS AND COMMITTEES OF THE BOARD

     The Company has an Executive  Committee of the Board composed of Dr. Samuel
D.  Waksal  (Chairman),  Robert F.  Goldhammer  and Dr.  Harlan W.  Waksal.  The
Executive  Committee  acts when the full Board is not  available  and on matters
delegated to it by the full Board. It has all the power of the full Board in the
management of the business and affairs of the Company,  except those powers that
by law cannot be delegated by the Board.  The  Executive  Committee did not meet
during the year ended December 31, 1996.

     The Company has an Audit Committee of the Board composed of Paul B. Kopperl
(Chairman),  David M.  Kies,  Richard  Barth and  William R.  Miller.  The Audit
Committee  considers matters relating to the adequacy of the Company's  internal
financial  controls and the  objectivity of the Company's  financial  reporting,
reviews the Company's  annual  financial  statements and the  performance of the
Company's auditors and makes  recommendations to the Board with respect to these
matters.  The Audit  Committee met two times during the year ended  December 31,
1996.


                                       4
<PAGE>

     The Company has a Compensation Committee of the Board composed of Robert F.
Goldhammer  (Chairman),  Paul B.  Kopperl,  Vincent T.  DeVita,  Jr. and Richard
Barth. The Compensation  Committee  reviews the compensation and related matters
of the Company's officers,  employees and consultants,  determines  compensation
levels and  approves  the other terms of such  arrangements,  and reports to the
Board thereon. The Compensation  Committee met three times during the year ended
December 31, 1996.

     The Company has a Corporate  Governance Committee composed of David M. Kies
(Chairman),  Paul B. Kopperl, William R. Miller, Robert F. Goldhammer and Harlan
W. Waksal. The Corporate Governance Committee reviews and makes  recommendations
regarding  corporate   organizational  and  governance  matters.  The  Corporate
Governance Committee did not meet during the year ended December 31, 1996.

     The Company has a Stock Option  Committee,  which is a subcommittee  of the
Compensation  Committee of the Board composed of Robert F. Goldhammer (Chairman)
and Vincent T. DeVita,  Jr. The Stock Option Committee  reviews and makes option
awards to the Company's  directors,  officers,  employees and  consultants.  The
Stock Option Committee met one time during the year ended December 31, 1996.

     During the year ended  December 31, 1996,  there were four  meetings of the
Company's  Board.  No incumbent  Director  attended  fewer than 75% of the total
number  of  meetings  of the  Board  and  of the  Committees  of the  Board,  or
subcommittees of such committee on which he served.  The Company does not have a
Nominating Committee.

                         INFORMATION CONCERNING OFFICERS

     Certain  information  concerning  each  officer of the  Company is provided
below.

     Samuel D. Waksal,  Ph.D., is the President and Chief  Executive  Officer of
the Company. Certain information concerning Dr. Waksal appears on pages 2 and 4.

     Harlan W. Waksal, M.D., is the Executive Vice President and Chief Operating
Officer of the Company.  Certain  information  concerning  Dr. Waksal appears on
pages 2 and 4.

     Peter  Bohlen,  Ph.D.,  54, has been Vice  President  of the Company  since
September 1996. From November 1995 to July 1996 he was Senior Director of IXSYS,
a privately-held  biotechnology  company.  From October 1987 to June 1996 he was
department head of the Molecular Biology Section of American  Cyanamid's Medical
Research  Division and director of the company's  angiogenesis  program.  He has
also held a variety of managerial and professorial positions in research both in
the United States and abroad.  Dr. Bohlen  received his Ph.D. in chemistry  from
the University of Berne in Switzerland and received postdoctoral training at the
Roche  Institute of Molecular  Biology and the University of California  Medical
School, San Francisco.

     Michael Feldman,  Ph.D., 71, became Vice President,  Discovery Research for
the  Company  in May 1995.  Prior  thereto he had  served as  Director  of Basic
Research  for  the  Company  since  1993.  Dr.  Feldman  is  former  head of the
Department  of Cell  Biology at the  Weizmann  Institute  of Science in Rehovot,
Israel, and a former dean of its graduate school. He has done pioneering work in
the areas of  transplantation  immunology,  differentiation  of lymphocytes  and
cancer  immunology.  In 1984,  he received the Griffuel  Award in France for his
work in cancer  metastasis,  and in 1986 received the  Rothschild  Award for his
work in immunology.  Dr. Feldman is a member of the Israeli  Academy of Sciences
and Humanities and the World Academy of Arts and Sciences.

     John A. Gilly, Ph.D., 39, joined the Company as its Vice  President-Product
and  Process  Development  in May  1992.  Since  March  1995,  he has been  Vice
President - Biopharmaceutical  Operations.  From February 1980 until joining the
Company,  Dr.  Gilly was employed by Connaught  Laboratories,  Inc.,  working in
various product development and research capacities. From October 1990 until May
1992,  Dr.  Gilly  was  the  Director  of  Product   Development  for  Connaught
Laboratories,   Inc.,  directing  all  laboratory  activities  for  new  product
development.   Dr.  Gilly  is  a  member  of  the  Board  of  Trustees  for  the
Biotechnology  Council of New  Jersey,  the United Way of  Somerset  County (New
Jersey) and the Somerset Partnership for Economic Development and Enterprise.


                                       5
<PAGE>

     Carl S.  Goldfischer,  M.D., 38, has served as Vice President,  Finance and
Strategic  Planning and Chief  Financial  Officer since May 1996. From June 1994
until joining the Company,  Dr.  Goldfischer served as a healthcare analyst with
Reliance Insurance. From June 1991 until June 1994, Dr. Goldfischer was Director
of Research for D. Blech & Co. Dr. Goldfischer  received a doctorate of medicine
from  Albert  Einstein  College of  Medicine in 1988 and served as a resident in
radiation  oncology at  Montefiore  Hospital of the Albert  Einstein  College of
Medicine until 1991. Dr.  Goldfischer is a director of Immulogic  Pharmaceutical
Corporation.

     John B. Landes, 49, has served as Vice  President-Business  Development and
General   Counsel   since   November   1992.   Prior   thereto,   he  was   Vice
President-Administration  and  Legal  since  December  1984.  He also  has  been
Secretary of the Company since April 1985 and served as its Treasurer from April
1984 through  September 1991, except for an interim period from December 1988 to
February 1991. From 1978 to 1984, Mr. Landes was an associate  attorney with the
Boston law firm of Mahoney, Hawkes and Goldings.

Section 16(a) Beneficial Ownership Reporting Compliance

     Ownership of and  transactions  in the  Company's  securities  by executive
officers and directors of the Company and owners of 10% or more of the Company's
outstanding  Common  Stock are  required to be reported  to the  Securities  and
Exchange  Commission  (the  "Commission")  pursuant  to  Section  16(a)  of  the
Securities  Exchange Act of 1934, as amended (the  "Exchange  Act").  During the
year ended December 31, 1996, based on information  received by the Company, Dr.
Jean Carvais, Mr. David M. Kies and Mr. William R. Miller each inadvertently did
not file one report with respect to a single transaction; Dr. Vincent T. DeVita,
Jr. and Dr.  Harlan W.  Waksal each  inadvertently  did not file one report with
respect to two transactions; and Dr. Samuel D. Waksal inadvertently did not file
one report with respect to six transactions, five of which were gifts.


                                       6
<PAGE>

         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

     The  following  table sets forth,  as of March 14, 1997  (unless  otherwise
noted),  certain  information  with respect to the  beneficial  ownership of the
Common Stock as to (i) each person known by the Company to own beneficially more
than five percent of the outstanding  shares of Common Stock, (ii) each director
and director  nominee of the Company and (iii) each Named  Officer  specified in
the Summary  Compensation  Table below,  and (iv) all  directors  and  executive
officers  of the  Company  as a group.  Except  as  otherwise  noted,  the named
beneficial owner has sole voting and investment power.

                                                         Shares
                                                      Beneficially     Percent
Name and Address(1)                                       Owned        Owned (2)
- -------------------                                   ------------     ---------
Samuel D. Waksal, Ph.D ............................     931,477(3)       3.9%
                                                                      
Harlan W. Waksal, M.D .............................     898,380(4)       3.7%
                                                                      
Robert F. Goldhammer ..............................     760,515(5)       3.2%
                                                                      
Pioneering Management Corp. .......................   1,849,000(6)       7.8%
60 State Street, Boston, MA 02114                                     
                                                                      
Oracle Group ......................................   2,144,000(7)       8.7%
712 Fifth Avenue, NY, NY 10019                                        
                                                                      
Vincent T. DeVita, Jr., M.D .......................      43,217(8)        *
                                                                          
Jean Carvais, M.D .................................      31,667(9)        *
                                                                          
Paul B. Kopperl ...................................      49,585(10)       *
                                                                          
William R. Miller .................................       1,397(11)       *
                                                                          
Richard Barth .....................................           0           *
                                                                          
David M. Kies .....................................      47,897(12)       *
                                                                          
John B. Landes ....................................     154,500(13)       *
                                                                          
John A. Gilly, Ph.D ...............................      21,600(14)       *
                                                                          
Carl S. Goldfischer, M.D ..........................      50,000(15)       *
                                                                          
All Directors and Executive Officers                                    
  as a group (10 persons) .........................   2,810,135(16)     11.7%
                                                                    
*    Less than 1%.

(1)  Unless otherwise noted, each person's address is in care of ImClone Systems
     Incorporated, 180 Varick Street, New York, New York 10014.


                                       7
<PAGE>

(2)  The percentage of stock owned by each stockholder is calculated by dividing
     (i) the number of shares deemed to be beneficially held by such stockholder
     as of March 14, 1997, as  determined  in accordance  with Rule 13d-3 of the
     Exchange  Act,  by (ii) the sum of (A)  23,690,199  which is the  number of
     shares of Common Stock outstanding as of March 14, 1997 plus (B) the number
     of shares of Common  Stock  issuable  upon  exercise of options or warrants
     held by such  stockholder  which were  exercisable  as of March 14, 1997 or
     which will become exercisable within 60 days after March 14, 1997.

(3)  Includes 437,305 shares issuable upon the exercise of warrants  exercisable
     as of March 14,  1997 or within 60 days  after  March 14,  1997 and  45,000
     shares  issuable upon the exercise of options  exercisable  as of March 14,
     1997 or within 60 days after March 14, 1997.

(4)  Includes 40,000 shares issuable upon the exercise of options exercisable as
     of March 14, 1997 or within 60 days after March 14, 1997 and 737,680 shares
     issuable upon the exercise of warrants  exercisable as of March 14, 1997 or
     within  60 days of March  14,  1997.  Includes  2,600  shares  owned by Dr.
     Waksal's sons, as to which he disclaims beneficial  ownership.  Included in
     the warrants to purchase an aggregate of 737,680  shares held by Dr. Waksal
     is a warrant to purchase  397,000  shares which was  scheduled to expire on
     March 24,  1997.  The  exercise  term of such  warrant to purchase  397,000
     shares has been extended until March 24, 1999.

(5)  Includes 31,667 shares issuable upon the exercise of options exercisable as
     of March 14, 1997 or within 60 days after March 14, 1997 and 379,990 shares
     issuable upon the exercise of warrants  exercisable as of March 14, 1997 or
     within 60 days after  March 14,  1997.  Includes  13,314  shares  held in a
     trust, as to which Mr. Goldhammer disclaims beneficial ownership.

(6)  This  information  is as of  December  31,  1996  and is  based on a second
     amendment to a Schedule 13G filed with the Commission on January 15, 1997.

(7)  Includes 925,000 shares issuable upon the exercise of warrants  exercisable
     as of March 14, 1997 or within 60 days of March 14, 1997. This  information
     is based on a Schedule 13F filed with the  Commission in December 1996. The
     Oracle Group is comprised of various  investment  partnerships  and managed
     accounts controlled by Larry N. Feinberg.

(8)  Includes 42,917 shares issuable upon the exercise of options exercisable as
     of March 14, 1997 or within 60 days after March 14, 1997.

(9)  Consists of 31,667 shares issuable upon the exercise of options exercisable
     as of March 14, 1997 or within 60 days after March 14, 1997.

(10) Includes 30,625 shares issuable upon the exercise of options exercisable as
     of March 14, 1997 or within 60 days after  March 14, 1997 and 2,460  shares
     issuable upon the exercise of warrants  exercisable as of March 14, 1997 or
     within 60 days  after  March 14,  1997.  Includes  500  shares  held by Mr.
     Kopperl's spouse as to which Mr. Kopperl disclaims beneficial ownership.

(11) Consists of 1,397 shares  issuable upon exercise of options  exercisable as
     of March 14, 1997 or within 60 days after March 14, 1997.

(12) Includes 1,397 shares  issuable upon exercise of options  exercisable as of
     March 14, 1997 or within 60 days after March 14, 1997, 4,000 shares held by
     Mr.  Kies as  custodian  for his son and  2,500  shares  held by Mr.  Kies'
     spouse.  Mr. Kies disclaims  beneficial  ownership as to the shares held by
     his spouse.

(13) Consists of 19,500 shares issuable upon the exercise of options exercisable
     as of March 14,  1997 or within 60 days after  March 14,  1997 and  135,000
     shares  issuable  upon the  exercise  of warrants  exercisable  as of March
     14, 1997 or within 60 days after March 14, 1997.

(14) Includes 15,000 shares issuable upon the exercise of options exercisable as
     of March 14, 1997 or within 60 days after March 14, 1997.

(15) Includes 50,000 shares issuable upon exercise of options  exercisable as of
     March 14, 1997 or within 60 days after March 14, 1997.

                                       8
<PAGE>

(16) Includes an aggregate of (i) 274,670  shares  issuable upon the exercise of
     options  exercisable as of March 14, 1997 or within 60 days after March 14,
     1997,  (ii)  1,557,435  shares  issuable  upon  the  exercise  of  warrants
     exercisable  as of March 14, 1997 or within 60 days after  March 14,  1997,
     and (iii) 18,914  shares as to which  beneficial  ownership is  disclaimed.
     Shares held by Messrs.  Gilly and Landes have not been included as they are
     not considered executive officers of the Company.

                              CERTAIN TRANSACTIONS

     In  January  1992,  the  Company  participated  in the  founding  of  Cadus
Pharmaceutical  Corporation ("Cadus") with scientists from Princeton University.
The Company  supported the initial growth and  development  of Cadus,  and as of
December 31, 1993 owned  approximately 28% of Cadus' common and preferred stock.
In December 1994, the Company completed the sale of one-half of its Cadus shares
for  proceeds  equaling  $3  million to High River  Limited  Partnership  ("High
River").  This was  recorded in the 1994  financial  statements  as a subsequent
event. In April 1995, the Company  completed the sale of the remaining  one-half
of its  shares of  capital  stock of Cadus for $3  million  to High  River.  The
Company  had a right to  repurchase  all such  shares of Cadus  anytime up until
October 27, 1996 for $5.25 per share which it did not exercise.  In exchange for
such right,  the Company  granted  High River two options to purchase  shares of
Common Stock.  One option is to purchase  150,000 shares at a price of $2.00 per
share, subject to adjustment under certain  circumstances,  and the other option
is to  purchase  300,000  shares  at a price  of $0.69  per  share,  subject  to
adjustment under certain circumstances. Both options became exercisable on April
27,  1995 and will  expire on April 26,  2000.  Dr.  Samuel  D.  Waksal  was the
Chairman of the board of  directors  of Cadus until July 1996 and  continues  to
serve on the board as a director.

     Dr. Samuel Waksal was indebted to the Company for outstanding cash advances
totaling  $101,000 as of December  31,  1996,  and the debt as of March 14, 1997
totaled  $95,394.  In April 1995, Dr. Waksal  provided the Company with a demand
promissory  note  pursuant to which he is  obligated  to repay the debt over the
two-year period ending April 30, 1997.

     In July 1995,  Mr. Robert F.  Goldhammer,  Chairman of the Board loaned the
Company $180,000 in exchange for a long-term note due two years from issuance at
an annual interest rate of 8%. As part of the  transaction,  Mr.  Goldhammer was
granted  warrants to purchase  36,000  shares of Common Stock at $1.50 per share
and additional  warrants to purchase  36,000 shares of Common Stock at $3.00 per
share. In May 1996, the Company and Mr. Goldhammer exchanged the note for 24,000
shares of Common Stock and the Company  paid the accrued and unpaid  interest on
the note in the amount of $10,000 in cash. The Company recorded an extraordinary
loss of $39,000 on the  extinguishment  of the debt.  The Company has registered
such shares of Common Stock with the Commission  under a registration  statement
in  accordance  with the  provisions  of the  Securities  Act of 1933 (the "1933
Act").

     During  the  year  ended  December  31,  1996,  the  Company  paid  Concord
International  Investment Group, LP approximately $163,000 for services rendered
by it to the Company in connection with structuring a then contemplated  product
related  financing  for the  Company's  cancer  therapeutic,  C225 which was not
completed. Such amount included expenses. Mr. Robert F. Goldhammer,  Chairman of
the Board of Directors, is a limited partner of Concord International Investment
Group, LP.

     The Company has retained Concord Capital  Management  International,  a New
York-based  money  management firm, to manage the investment of a portion of the
Company's  marketable  securities.  Mr.  Robert F.  Goldhammer  is a partner  of
Concord  Capital  Management  International.  During the year ended December 31,
1996, the Company paid to Concord Capital Management  International an aggregate
of $24,000 for services rendered.

     In January 1996, the Company paid Delano & Kopperl Financial Advisors, Inc.
a total of approximately  $50,000 for services  rendered by it to the Company in
connection with structuring a then  contemplated  product related  financing for
C225 which was not completed.  Such amount included expenses. Paul B. Kopperl, a
director of the Company, is President, director, and a 30% stockholder of Delano
& Kopperl, Inc., successor to Delano & Kopperl Financial Advisors, Inc.

     During the year ended  December 31, 1996,  the Company paid Dr.  Vincent T.
DeVita,  Jr., a director  of the  Company,  a total of $100,000  for  consulting
services provided to the Company by Dr. DeVita.


                                       9
<PAGE>

                             EXECUTIVE COMPENSATION

Report of Compensation Committee

     The  Compensation  Committee of the Board of Directors  (the  "Compensation
Committee"  or  the  "Committee")  is  responsible  for  developing  and  making
recommendations   to  the  Board  with  respect  to  the   Company's   executive
compensation  policies.  In  addition,  pursuant to  authority  delegated by the
Board,  the  Committee  determines  the  compensation  policy of the Company and
determines on an annual basis the compensation to be paid to the Chief Executive
Officer and  approves  compensation  to other  officers of the  Company,  at the
recommendation of the Chief Executive Officer and other supervising personnel.

     The Compensation  Committee is composed of Robert F. Goldhammer (Chairman),
Richard Barth, Vincent T. DeVita, Jr. and Paul B. Kopperl.

Overall Philosophy

     The Company's  overall  executive  compensation  philosophy is based on the
premise that  compensation  should be set at levels that  support the  Company's
business strategies and long-term  objectives in order to attract,  motivate and
retain those  executives  critical to the overall  success of the  Company,  and
should  reward  executives  for  their   contributions  to  the  enhancement  of
shareholder  value. The key elements of the executive  compensation  package are
base  salary,  annual  incentive  awards  and stock  options  and  warrants.  In
establishing base salaries,  annual incentive awards and awards of stock options
and  warrants,   the  Compensation  Committee  considers  periodic  compensation
surveys,    including   those   provided   by   third   parties   covering   the
biopharmaceutical industry.  Officers' compensation is compared to that of other
executives in peer group surveys.

     In evaluating each senior  executive's  performance,  the Company generally
conforms to the following process:

     o    Company and  individual  goals and objectives are set at the beginning
          of the performance cycle.

     o    At the end of the performance  cycle, the executive's  manager,  or in
          the case of the Chief Executive Officer,  the Compensation  Committee,
          evaluates the  accomplishment  of the executive's goals and objectives
          and his or her contributions to the Company.

     o    The  executive's  performance  is  then  reviewed  by the  executive's
          manager with the executive and consideration is given to goals for the
          following performance cycle.

     o    The  comparative  results,   combined  with  comparative  compensation
          practices  of  other  companies  in the  industry,  are  then  used to
          determine salary, bonus, and stock option and warrant levels.

     The   Compensation   Committee   uses  no  set  formulas  in  making  these
determinations  and may afford  different  weight to different  factors for each
senior  executive.  Such  weighting may vary from year to year.  In  determining
compensation,  the  Committee  does not attempt to correlate  compensation  with
specific financial results, such as revenues or profits, for the current period.
This is in large part due to the  nature of the  biopharmaceutical  industry  in
which  traditional  evaluations  of  corporate  performance  may  not  apply  in
reviewing the performance of executives.  At the Company's stage of development,
in  determining  compensation,  the  Committee  looks toward the progress of the
Company's  research and development  programs,  its ability to gain  appropriate
levels of support for its programs through its strategic partnering  agreements,
its ability to attract and retain  talented  employees and its ability to secure
capital  sufficient  for its product  development  programs to achieve rapid and
effective commercialization.


                                       10
<PAGE>

Base Salary

     At the end of each year,  the Committee  reviews and  establishes  the base
salary of the Chief Executive Officer based on a comparison to national surveys,
taking into consideration the Company's  performance and current  circumstances,
accomplishment of his goals and objectives and his contributions to the Company.
The Committee also reviews and approves, or modifies if necessary, a salary plan
for the other  senior  executives  prepared  by the Chief  Executive  Officer in
conjunction with other senior  personnel which is based on appropriate  national
comparisons with respect to the biopharmaceutical  industry and judgments on the
performance  of each  executive  and his or her  contributions  to the Company's
performance.

Annual Incentive Awards

     Although the Company does not have a formal bonus plan for its  management,
the  Compensation   Committee  determines  annual  incentive  awards  to  senior
executives  from  time to time  based  on  individual  performance  and  Company
performance.  Specific  performance goals of each executive are determined early
each  year  in  direct  consultation  with  the  executive's  supervisor.  These
performance  goals  include  successful  and cost  efficient  management  of the
executive's department and specific contributions made by that department to the
immediate and ultimate goals of the Company.  For the Chief  Executive  Officer,
such goals are determined in reference to the CEO's plan for the coming year for
the Company as a whole, as presented to the Board of Directors.  The awarding of
annual incentive awards takes into  consideration  individual efforts as well as
performance of the Company as a whole. In evaluating  performance of the Company
as a whole, several factors are examined, including productivity of research and
development  programs,  successful movement of development stage products toward
commercialization,  fostering development of successful corporate  partnerships,
expense  control,  financing  efforts and  progress  of the  Company  toward its
short-term and long-term goals.

Long-Term Incentive Compensation

     Stock options and warrants are  considered as long-term  incentives and are
intended to link the interests of the executive  with those of the  stockholder.
Stock  options and warrants  will provide value to the grantee when the price of
the Company's stock increases.

     The  Compensation  Committee  conducts a formal review from time to time of
the stock option and warrant holdings and vesting schedule of each officer.  The
Compensation  Committee  authorizes  stock option  grants  (and,  in some cases,
grants of  warrants)  to the  executives  with  consideration  to the growth and
performance of the Company, individual performance and contribution, total stock
option and warrant and vesting levels and length of service.

     In the year ended  December 31, 1996,  the CEO and the other Named Officers
(as hereinafter  defined) were awarded no warrants,  and were awarded options to
purchase an aggregate of 415,000  shares of Common Stock.  See "Option Grants in
Last Fiscal Year."

Deductibility of Compensation

     The Committee has reviewed the impact of recently enacted Section 162(m) of
the Internal Revenue Code of 1986 as amended (the "Code"),  which,  beginning in
1994, limits the deductibility of certain otherwise  deductible  compensation in
excess of $1 million  paid to the Chief  Executive  Officer  and the other Named
Officers (as hereinafter defined). It is the policy of the Company to attempt to
have its executive  compensation  plans treated as tax  deductible  compensation
whenever,  in the  judgment  of the  Compensation  Committee,  to do so would be
consistent with the objectives of that compensation plan.

Chief Executive Officer Compensation

     The key elements of the  compensation  for the Chief Executive  Officer are
base  salary,  annual  incentive  awards  and  stock  options  or  warrants.  In
evaluating Dr. Samuel Waksal's 1996  performance and in determining Dr. Waksal's
1997  compensation,  the  Compensation  Committee,  along  with the full  Board,
considered the performance of the Company in 1996. This included the progress in
clinical and manufacturing  efforts for the Company's lead interventional cancer
therapeutic, C225, progress of the Company's BEC-2 cancer vaccine product toward
clinical trials and resultant modification of the Company's agreement with Merck
KGaA,  successful  completion of financings to support the Company's current and
future operations,  and the completion of 


                                       11
<PAGE>

significant  additions  to the  Board of  Directors.  The Board  also  noted Dr.
Waksal's  impact  on  the  solidification  of a  significant  research  program,
including the hiring of a Vice  President of Research,  and positive steps taken
in financial administration and strategic planning.


                                           Compensation Committee

                                           Robert F. Goldhammer, Chairman
                                           Richard Barth
                                           Vincent T. DeVita, Jr.
                                           Paul B. Kopperl

Compensation Committee Interlocks and Insider Participation

     As of December 31, 1996,  the members of the  Compensation  Committee  were
Richard Barth, Vincent T. DeVita, Jr., Robert F. Goldhammer  (Chairman) and Paul
B.  Kopperl.  Jean Carvais also served on the  Compensation  Committee  during a
portion of the year  ended  December  31,  1996.  No member of the  Compensation
Committee during 1996 is a current or former officer of the Company.  During the
year ended December 31, 1996, the Company paid Concord International  Investment
Group, LP approximately  $163,000 for services  rendered by it to the Company in
connection with structuring a then  contemplated  product related  financing for
C225 which was not  completed.  Such amount  included  expenses.  Mr.  Robert F.
Goldhammer is a limited partner of Concord  International  Investment Group. The
Company has retained Concord Capital Management International,  a New York-based
money  management  firm, to manage the  investment of a portion of the Company's
marketable securities.  Mr. Robert F. Goldhammer is a partner of Concord Capital
Management  International.  During the year ended December 31, 1996, the Company
paid to Concord  Capital  Management  International  an aggregate of $24,000 for
services rendered.  In January 1996, the Company paid Delano & Kopperl Financial
Advisors,  Inc. a total of approximately  $50,000 for services rendered by it to
the Company in connection with structuring a then  contemplated  product related
financing for C225 which was not completed.  Such amount included expenses. Paul
B.  Kopperl,  a director  of the  Company,  is  President,  director,  and a 30%
stockholder of Delano & Kopperl,  Inc.,  successor to Delano & Kopperl Financial
Advisors,  Inc.  During the year ended  December 31, 1996,  the Company paid Dr.
Vincent T. DeVita,  Jr. a total of $100,000 for consulting  services provided to
the Company by Dr. DeVita. See "Certain Transactions," above.


                                       12
<PAGE>

                             STOCK PRICE PERFORMANCE

     The graph  below  provides a  comparison  of the  cumulative  total  return
(assuming  reinvestment of dividends) for the Company (which paid no dividends),
The Nasdaq Stock  Market (U.S.  Companies)  Total Return  Index,  and the Nasdaq
Pharmaceutical  Stocks Total Return Index for the period commencing November 19,
1991, the date the Company  completed its initial public  offering and commenced
trading on the Nasdaq  National  Market,  through  December 31, 1996.  The graph
assumes  $100 was invested at the  beginning  of such  period.  The Nasdaq Stock
Market (U.S.  Companies) Total Return Index comprises all domestic common shares
traded on the Nasdaq National Market and the Nasdaq SmallCap Market.  The Nasdaq
Pharmaceutical  Stocks Total Return Index  represents all  companies,  including
biotechnology  companies,  trading  on  Nasdaq  classified  under  the  Standard
Industrial Classification Code for pharmaceuticals.

                           Comparison of Total Return

  [The following table was represented by a line chart in the printed material]

   IMCLONE, NASDAQ STOCK MARKET (U.S. COMPANIES) TOTAL RETURN INDEX AND NASDAQ
                    PHARMACEUTICAL STOCKS TOTAL RETURN INDEX
 
      ImClone Systems                NASDAQ                  Pharmaceutical
      ---------------                ------                  --------------
  Date     Price   Index      Date    Price   Index       Date    Price   Index 
  ----     -----   -----      ----    -----   -----       ----    -----   ----- 
11/19/91  13.5000   100     11/19/91  164.38   100      11/19/91  314.09   100
12/31/91  18.0000   133     12/31/91  187.21   114      12/31/91  387.27   123
 3/31/92  15.2500   113      3/31/92  193.09   117       3/31/92  335.27   107
 6/30/92  10.2500    76      6/30/92  179.89   109       6/30/92  281.24    90
 9/30/92   6.2500    46      9/30/92  187.28   114       9/30/92  264.84    84
12/31/92  11.5000    85     12/31/92  217.88   133      12/31/92  322.27   103
 3/31/93   9.2500    69      3/31/93  221.97   135       3/31/93  231.98    74
 6/30/93   6.0000    44      6/30/93  226.23   138       6/30/93  244.48    78
 9/30/93   9.2500    69      9/30/93  245.30   149       9/30/93  265.05    84
12/31/93   6.1250    45     12/31/93  250.12   152      12/31/93  287.25    91
 3/31/94   3.6250    27      3/31/94  239.60   146       3/31/94  234.29    75
 6/30/94   2.3750    18      6/30/94  228.40   139       6/30/94  204.50    65
 9/30/94   1.7500    13      9/30/94  247.31   150       9/30/94  230.38    73
12/31/94   0.9370     7     12/31/94  244.49   149      12/31/94  216.24    69
 3/31/95   0.6875     5      3/31/95  266.42   162       3/31/95  233.45    74
 6/30/95   1.8750    14      6/30/95  304.74   185       6/30/95  271.42    86
 9/30/95   3.7500    28      9/30/95  341.42   208       9/30/95  338.08   108
12/31/95   7.6250    56     12/31/95  345.48   210      12/31/95  394.98   126
 3/31/96   8.7500    65      3/31/96  361.86   220       3/31/96  411.62   131
 6/30/96   9.1250    68      6/30/96  391.40   238       6/30/96  399.96   127
 9/30/96   8.6250    64      9/30/96  405.34   247       9/30/96  408.98   130
12/31/96   9.7500    72     12/31/96  425.26   259      12/31/96  395.98   126


                                       13
<PAGE>

                           SUMMARY COMPENSATION TABLE

     The  Summary   Compensation   Table  sets  forth  the  cash  and   non-cash
compensation  awarded to,  earned by, or paid to the Company's  Chief  Executive
Officer  and the four most  highly  compensated  officers  (other than the Chief
Executive Officer) for the years ended December 31, 1996,  December 31, 1995 and
December  31, 1994 who were  serving as officers at December  31, 1996 and whose
total salary and bonus  exceeded  $100,000 for the year ended  December 31, 1996
(the "Named Officers").

<TABLE>
<CAPTION>
                                            Annual Compensation                            Long-Term Compensation Awards
                           -----------------------------------------------------   -------------------------------------------
Name and                                                           Other Annual    Securities Underlying          All Other
Principal Position         Year          Salary        Bonus       Compensation    Options and Warrants        Compensation($)
- ------------------         ----          ($)(1)        ($)(2)          ($)(3)             (#)(4)               ---------------
                                         ------        ------      -------------   --------------------
                                                                                          
<S>                        <C>          <C>          <C>               <C>               <C>                       <C>       
Samuel D. Waksal           1996         $225,000     $100,000(5)       --                 45,000                   $10,435(6)
President and Chief        1995          190,000      150,000          --                350,000                    10,435(6)
Executive Officer          1994          190,000         --            --                   --                      10,435(6)

Harlan W. Waksal           1996          195,000      100,000(7)       --                 40,000                       -- 
Executive Vice             1995          170,000      125,000          --                   --                         -- 
President and Chief        1994          170,000         --            --                   --                         -- 
Operating Officer

John B. Landes             1996          165,000       50,000          --                 30,000                       -- 
Vice President,            1995          150,000       30,000          --                   --                         -- 
Business Development       1994          150,000         --            --                   --                         -- 
and General Counsel

John A. Gilly              1996          165,000      100,000          --                 75,000                       -- 
Vice President,            1995          137,000       50,000          --                   --                         -- 
Biopharmaceutical          1994          110,000         --            --                   --                         -- 
Operations

Carl S. Goldfischer(8)     1996          109,000       75,000          --                225,000                       -- 
Vice President,            1995             --           --            --                   --                         -- 
Financial and Strategic    1994             --           --            --                   --                         -- 
Planning
and Chief Financial
Officer
</TABLE>

(1)  Amounts shown include  compensation  deferred pursuant to Section 401(k) of
     the Internal Revenue Code of 1986, as amended ("the Code").

(2)  Although the Company has no formal bonus plan, the  Compensation  Committee
     of the Board,  in its  discretion,  may award  bonuses to  officers  of the
     Company.  The  Company has paid  bonuses  based on  individual  and Company
     performance.  Amounts  shown  include  awards  paid  relative  to  services
     rendered in each of the last three fiscal years.  All bonus awards for each
     of the last three fiscal years were paid in cash.  Bonuses are recorded for
     the period in which they were earned.

(3)  Excludes  prerequisites  and other personal benefits for each Named Officer
     which  did not  equal  or  exceed  the  lesser  of  $50,000  or 10% of such
     individual's  base salary and bonus for the years ended  December 31, 1996,
     December 31, 1995 and December 31, 1994, respectively.

(4)  Options or warrants to purchase  the number of shares of Common Stock shown
     are recorded for the period in which they were granted.

(5)  During the fiscal year ended December 31, 1996, the Compensation  Committee
     determined to award Dr.  Samuel D. Waksal an additional  bonus in an amount
     to be determined, subject to the Company's completion by June 30, 1997 of a
     corporate partnership,  or similar strategic  arrangement,  with acceptable
     terms.

(6)  Consists of premium payments on a term life insurance policy for Dr. Samuel
     D. Waksal under which his daughters are the beneficiaries.


                                       14
<PAGE>

(7)  During the fiscal year ended December 31, 1996, the Compensation  Committee
     determined to consider the payment of an additional  $100,000  bonus to Dr.
     Harlan W. Waksal at the end of the six month period ending June 30, 1997.

(8)  Dr. Goldfischer commenced employment with the Company on May 20, 1996.

                        OPTION GRANTS IN LAST FISCAL YEAR

     The following table sets forth certain information relating to stock option
grants to the Named Officers during the year ended December 31, 1996.

<TABLE>
<CAPTION>
                                                                                                      Potential Realizable
                        Number of        % of Total                                              Value at Assumed Annual Rates of
                       Securities      Options Granted                                               Stock Price Appreciation
                       Underlying       to Employees        Exercise Price                                for Option Term (3)
       Name          Options Granted   in fiscal year(1)     ($/share)(2)    Expiration Date       0%($)        5%($)       10%($)
       ----          ---------------   ----------------     --------------   ---------------     -----------------------------------
<S>                     <C>                  <C>            <C>                     <C>             <C>      <C>           <C>      
Samuel D. Waksal        45,000(4)            6%               $ 10.875         June 9, 2006         $0       $  307,765    $ 779,938
                                                                                                                         
Harlan W. Waksal        40,000(4)            5%                 10.875         June 9, 2006          0          273,569      693,278
                                                                                                                         
John B. Landes          30,000(5)            4%                 10.875         June 9, 2006          0          205,177      519,958
                                                                                                                         
John A. Gilly           75,000(5)            10%                10.875         June 9, 2006          0          512,942    1,299,896
                                                                                                                         
Carl S. Goldfischer    225,000(6)            31%                 8.30        April 23, 2006       945,000     2,713,766    5,427,401
</TABLE>                                                

(1)  The Company granted options to purchase a total of 732,375 shares of Common
     Stock to employees  during the year ended  December 31, 1996.  All of these
     options were granted  pursuant to either the Company's 1986 Incentive Stock
     Option Plan,  as amended,  the 1986  Non-Qualified  Stock  Option Plan,  as
     amended,  the 1996 ISO Plan or the 1996  Non-Qualified  Plan at an exercise
     price that equaled or exceeded the fair market value of the Common Stock on
     the date of grant, except as discussed in footnote 6.

(2)  Except as  discussed  in footnote 6, all options  were  granted to purchase
     Common Stock at an exercise  price that equaled or exceeded the fair market
     value of the Common Stock on the date of grant,  as  determined by the last
     sale price as reported by the Nasdaq National Market.

(3)  The amounts set forth in the three  columns  represent  hypothetical  gains
     that might be  achieved  by the  optionees  if the  respective  options are
     exercised at the end of their terms. These gains are based on assumed rates
     of stock price appreciation of 0%, 5% and 10% compounded  annually from the
     dates the respective  options were granted.  The 0% appreciation  column is
     included  because,  except as  discussed  in footnote  6, the options  were
     granted with exercise  prices which equaled or exceeded the market price of
     the  underlying  Common  Stock on the date of grant,  and thus will have no
     value unless the Company's stock price increases above the exercise prices.

(4)  These options were vested and  exercisable in their entirety on the date of
     grant.

(5)  These options will vest and become  exercisable  with respect to 25% of the
     shares of Common  Stock  underlying  each option on each of June 10,  1997,
     June 10, 1998,  June 10, 1999 and June 10, 2000,  subject to the respective
     optionee's  continued  employment with the Company on the relevant  vesting
     dates.

(6)  This option vested and became  exercisable  as to 50,000 shares on the date
     of grant and will become  exercisable as to 33 1/3% of the remaining shares
     on  each of May 20,  1997,  May 20,  1998  and  May 20,  1999,  subject  to
     optionee's  continued  employment with the Company on the relevant  vesting
     dates.  The  exercise  price for this option was  determined  by taking the
     average of the closing  prices for the sixty day period  ending on the date
     of grant.  The closing  price of the Common  Stock on the date of grant was
     $12.50. See "Employment Agreements," below.


                                       15
<PAGE>

               OPTION/WARRANT EXERCISES AND FISCAL YEAR-END VALUES

     The following table sets forth option and warrant exercises during the year
ended  December 31, 1996 by the Named  Officers and the value of the options and
warrants held by such persons on December 31, 1996,  whether or not  exercisable
on such date.

<TABLE>
<CAPTION>

                     Number of  
                      Shares                         Shares Underlying Unexercised            Value of Unexercised In-The-Money
                    Acquired on      Value      Options/Warrants at December 31, 1996(#) Options/Warrants at December 31, 1996($)(2)
    Name            Exercise(#)  Realized($)(1)     Exercisable       Unexercisable           Exercisable         Unexercisable
    ----            -----------  --------------     -----------       -------------           -----------         -------------
<S>                   <C>          <C>                <C>                 <C>                 <C>                    <C>  
Samuel D. Waksal      244,692      $2,247,995         582,305                --               $3,032,766            $   --
                                                                                                                 
Harlan W. Waksal         --              --           777,680                --                6,088,013                --
                                                                                                                 
John B. Landes         14,500         117,438         155,500              30,000              1,288,000                --
                                                                                                                 
John A. Gilly          15,000         116,250          15,000              75,000                127,500                --
                                                                                                                 
Carl S. Goldfischer      --              --            50,000             175,000                 72,500             253,750   

</TABLE>

(1)  The values realized were calculated by multiplying the closing market price
     of the Common  Stock on the date of  exercise by the  respective  number of
     shares and subtracting  the aggregate  exercise  price.  Accordingly,  such
     values realized assume a sale of such Common Stock on the date of exercise,
     which may not necessarily have occurred.

(2)  The values were  calculated by multiplying  the closing market price of the
     Common  Stock at  December  31,  1996  ($9.75 per share as  reported by the
     Nasdaq National Market on that date) by the respective number of shares and
     subtracting  the  aggregate  option  exercise  price,  without  making  any
     adjustments for vesting,  termination  contingencies or other variables. If
     the  exercise  price of an option  is equal to or  greater  than  $9.75 the
     option is deemed to have no value.

Other Benefit Plans

     The Company has no defined benefit or defined contribution retirement plans
other than the ImClone Systems  Incorporated  401(k) Employee  Savings Plan (the
"Plan") established under Section 401(k) of the Code.  Contributions to the Plan
are  voluntary,  and  substantially  all  full-time  employees  are  eligible to
participate.  While the Plan  provides  for the  ability of the Company to match
certain  employee   contributions,   the  Company  has  not  made  any  matching
contributions and has no present intention to do so.

                              EMPLOYMENT AGREEMENTS

     In May 1996, the Company entered into an employment agreement with Dr. Carl
S.  Goldfischer to serve as the Company's Vice President,  Finance and Strategic
Planning and Chief Financial Officer. The employment agreement is for an initial
term of two years, subject to certain earlier termination provisions, and may be
extended upon the mutual  agreement of the parties.  Pursuant to the  agreement,
Dr.  Goldfischer  receives an annual salary equal to $175,000,  is entitled to a
bonus  equal to $75,000 at the end of his first year (which was paid in December
1996) and is  entitled to a bonus for his second  year of  employment  as may be
determined by the Board. In the event Dr. Goldfischer's employment is terminated
by the Company  during the initial or any  extended  term of the  agreement  (i)
without  cause  (as  defined  therein),  (ii)  as  a  result  of  the  Company's
disposition of substantially all its property, business or assets, or (iii) as a
result of a merger  resulting  in a shift of voting  control of more than 75% of
the Company's stock,  Dr.  Goldfischer is entitled to receive a pro rata portion
of his annual salary and cost of comparable  benefits for a period of ten months
should  his  termination  be  effective  during  1997 and for a period of twelve
months should his  termination be effective in 1998.  Pursuant to the agreement,
Dr. Goldfischer received an option to purchase an aggregate of 225,000 shares of
Common Stock at a per share  exercise price equal to $8.30 which was the average
of the closing prices of the Common Stock for the sixty day period ending on the
date of grant.  The option vested and became  exercisable as to 50,000 shares on
the date of grant  and will  vest and  become  exercisable  as to 33 1/3% of the
remaining shares on each of the three anniversaries following the effective date
of  the  employment  agreement.  The  option  terminates  in its  entirety  upon
termination  of  Dr.  Goldfischer's  employment.  Dr.  Goldfischer's  employment
agreement  further  requires  him to  maintain  the  confidentiality  of Company
information and prohibits him from competing with the Company during the term of
the employment  agreement,  any extensions  thereof and for a period of one year
after the agreement's termination.


                                       16
<PAGE>

                                 PROPOSAL NO. 2

           PROPOSED AMENDMENTS TO THE 1996 INCENTIVE STOCK OPTION PLAN

     In February 1996, the Company's Board adopted the 1996 ISO Plan in order to
enable the Company to attract and retain key  executives  and  employees  and to
promote the interests of the Company by affording such persons an opportunity to
acquire a proprietary  interest in the Company  pursuant to stock options issued
by the Company,  and thus to create in such persons increased  personal interest
in the continued  success of the Company.  Subject to shareholder  approval,  on
April 3, 1997 the Board approved amendments to the 1996 ISO Plan to (i) increase
the total  number of shares of  Common  Stock  which may be issued  pursuant  to
options  granted  under the 1996 ISO Plan from  1,500,000  to  3,000,000,  which
number shall be reduced by the number of shares which have been or may be issued
pursuant to options granted under the 1996 Non-Qualified  Plan; and (ii) provide
that any of the Compensation  Committee,  the Stock Option Committee (which is a
subcommittee of the Compensation Committee) or the Board may administer the 1996
ISO Plan and that such persons need not be "disinterested  persons" as such term
was  formerly  defined  in Rule 16b-3  promulgated  under  Section  16(b) of the
Securities Exchange Act of 1934, as amended (the "Exchange Act") (Proposal No. 2
on your proxy card).

     The Board  believes that a key  ingredient in  attracting,  motivating  and
retaining qualified  executives and employees is to offer significant  potential
rewards based upon the Company's success, through the issuance of stock options.
The  amendment  to the 1996 ISO Plan  increasing  the  shares  of  Common  Stock
authorized thereunder presented herein to the stockholders for their approval is
designed  to assist the Company in  accomplishing  this goal.  Of the  1,500,000
shares of Common Stock currently  authorized in the aggregate under the 1996 ISO
Plan and the 1996  Non-Qualified  Plan, at April 4, 1997 an aggregate of 446,228
shares remained available for future grants.

     The following summary  description of the 1996 ISO Plan is qualified in its
entirety by the full text of the 1996 ISO Plan, as proposed to be amended, which
may be obtained by the Company's  stockholders  upon request to the Secretary of
the Company. The 1996 ISO Plan was approved by the Board and subsequently by the
shareholders.  On April 3, 1997 the amendments discussed herein were approved by
the Board subject to shareholder approval.

     The last sale price of a share of the Company's Common Stock as reported by
the Nasdaq National Market on April 4, 1997 was $5 1/8.

Description of the 1996 ISO Plan

     Administration  of the 1996  ISO  Plan.  The  1996  ISO Plan as  originally
adopted  provided that such plan be administered by the Stock Option  Committee,
which is a subcommittee  of the  Compensation  Committee,  comprised of not less
than two  persons to be  appointed  by the Board  from among the  members of the
Board.  It also  provided  that  members of the Stock Option  Committee  are not
eligible to become  participants  under the 1996 ISO Plan while they are members
of the Stock Option  Committee or for a period of three  months  thereafter  and
were required,  unless otherwise  determined by the Board, to be  "disinterested
persons" as such term was defined in Rule 16b-3 under the Exchange Act.  Subject
to shareholder approval, the Board has amended the 1996 ISO Plan to provide that
any of the Compensation Committee, the Stock Option Committee (collectively, the
"Committees") or the Board may administer the 1996 ISO Plan. Further, subject to
shareholder  approval,  the Board has  amended  the 1996 ISO Plan to remove  the
requirement that such persons  administering the 1996 ISO Plan be "disinterested
persons" as such term was  formerly  defined  under Rule  16b-3.  Rule 16b-3 was
substantially amended in 1996 and, as a result, no longer requires those persons
administering  a plan to be  "disinterested  persons."  Further,  Rule 16b-3, as
amended,  now permits the full Board,  as well as  committees  thereof,  to make
grants and awards  thereunder and otherwise  administer  the plan.  Because Rule
16b-3  has  been  amended  to  give   companies   greater   flexibility  in  the
administration of their plans,  subject to shareholder  approval,  the Board has
amended the 1996 ISO Plan to take  advantage  of this  greater  flexibility  and
remove these requirements as to administration.  Such amendments to the 1996 ISO
Plan are included as part of this Proposal No. 2 for vote by the shareholders at
the Meeting.


                                       17
<PAGE>

     The members of the Committees serve at the pleasure of the Board, which has
the power at all times to remove  members from the  Committees or to add members
thereto.  Vacancies in the Committees,  however caused,  are filled by action of
the Board.  All decisions or  determinations  of the Committees or the Board are
made by the  majority  vote or decision of all of its  respective  members.  The
interpretation  and  construction  by any of the  Committees or the Board of the
provisions of the 1996 ISO Plan or of the options  granted  thereunder are final
unless, in the case of the Committees, otherwise determined by the Board.

     Eligibility  to  Participate  in the  1996 ISO  Plan.  Key  executives  and
employees of the Company are  eligible  for the grant of options  under the 1996
ISO Plan. As of April 4, 1997, 98 persons were  eligible to  participate  in the
1996 ISO Plan.

     Common Stock  Subject to the 1996 ISO Plan.  The  original  total number of
shares  available to be issued in the aggregate  under the 1996 ISO Plan and the
1996 Non-Qualified Plan was 1,500,000.  The Board has amended the 1996 ISO Plan,
subject to shareholder approval, to increase such number of shares to 3,000,000.
Such  amendment  is  included  as part of this  Proposal  No.  2 for vote by the
shareholders at the Meeting.  A similar amendment to the 1996 Non-Qualified Plan
is begin presented to shareholders as part of Proposal No. 3 below. The issuance
and sale of the shares of Common Stock currently  authorized  under the 1996 ISO
Plan and the 1996 Non-Qualified  Plan is covered by a Registration  Statement on
Form S-8 on file with the  Commission;  provided that sales by affiliates of the
Company are subject to the volume  limitations  contained  in Rule 144 under the
Securities Act.

     If any change is made in the shares of Common Stock subject to the 1996 ISO
Plan or subject to any option  granted under the 1996 ISO Plan (through  merger,
consolidation,  reorganization,   recapitalization,  stock  dividend,  split-up,
combination of shares,  exchange of shares,  issuance of rights to subscribe, or
change  in  capital  structure),  appropriate  adjustments  shall be made by the
Committees or the Board as to the maximum  number of shares  subject to the 1996
ISO Plan and the  number of shares and price per share  subject  to  outstanding
options as shall be  equitable  to prevent  dilution  or  enlargement  of option
rights.  Any such  determination  made by the  Committees  or the Board shall be
final, binding and conclusive upon each participant.

     Amendments or Discontinuation of the 1996 ISO Plan. The Board may make such
amendments,  changes and additions to the 1996 ISO Plan, or may  discontinue and
terminate  the  1996  ISO  Plan,  as it may deem  advisable  from  time to time;
provided,  however,  that no action may affect or impair any options theretofore
granted  under the 1996 ISO  Plan,  and  provided,  further,  however,  that the
affirmative vote of the owners of a majority of the outstanding shares of Common
Stock  present  in person  or by proxy and  entitled  to vote  thereon  shall be
necessary  to effect  any  amendment  to the 1996 ISO Plan  which  would  either
increase the number of shares of Common Stock  subject to options  granted under
such plan, or which would authorize Incentive Stock Options at a price below the
fair market value (or 110%  thereof,  if the employee  owns more than 10% of the
voting  securities  of the  Company  at the time of the  grant) of the shares of
Common Stock subject to the option.  In addition to the  requirement in the 1996
ISO Plan that the  shareholders  approve an increase in shares  authorized under
the 1996 ISO Plan, the amendments being presented hereby to the shareholders for
vote  thereon,  are being so presented  for  purposes of  complying  with Nasdaq
National Market listing requirements.

     ERISA.  The 1996 ISO Plan is not subject to any  provision  of the Employee
Retirement Income Security Act of 1974, as amended ("ERISA").

     Nontransferability.  Options granted  pursuant to the 1996 ISO Plan are not
transferable by the holder thereof,  other than by will, the laws of descent and
distribution,  or (if authorized in the applicable ISO Agreement)  pursuant to a
qualified  domestic relations order, as defined by the Code, or Title I of ERISA
or the rules thereunder.

     Granting of Options. Any of the Committees or the Board shall determine the
key executives and employees to be granted  options under the 1996 ISO Plan, the
number of shares of Common Stock subject to such options, the exercise prices of
options,  the terms thereof and any other provisions not  inconsistent  with the
1996 ISO Plan.  To the extent the  aggregate  fair market  value of Common Stock
with respect to which options are  exercisable  for the first time by any holder
during any  calendar  year (under all plans of the Company and any of its parent
and  subsidiary  corporations)  exceeds  $100,000,  such excess  options will be
treated as  non-qualified  stock options.  All stock options granted pursuant to
the 1996 ISO Plan shall be evidenced by stock option agreements,  which need not
be identical, between the Company and the participant in such form as any of the
Committees or the Board shall from time to time approve, subject to the terms of
the 1996 ISO Plan.  Each stock option  agreement shall state the total number of
shares of Common  Stock with  respect to which the option is granted,  the terms
and conditions of the option, and the exercise price or prices thereof.

     Life of the 1996 ISO Plan.  Options may be granted  under the 1996 ISO Plan
until February 25, 2006.


                                       18
<PAGE>

     Exercise  Price.  The price at which the shares of Common Stock  subject to
each option granted under the 1996 ISO Plan may be purchased (the "option price"
or "exercise  price") shall be determined by any of the Committees or the Board.
Any of the  Committees  or the Board  shall have the  authority  at the time the
option is granted to prescribe in any stock option  agreement that the price per
share, with the passage of  pre-determined  periods of time, shall increase from
the original price to higher prices. However, in no event may the exercise price
of an option granted under the 1996 ISO Plan be less than 100% (110% in the case
of 10% stockholders) of the fair market value of the Common Stock on the date of
the grant.  The exercise price of all options granted under the 1996 ISO Plan is
payable in full upon the exercise of such option, which payment shall be in cash
or stock  (that has been owned by the  Participant  for at least six  months) or
notes of the Company, or, as agreed to by the Board, other consideration.

     Terms and Conditions of Exercise; Exercise Period. The terms and conditions
of any  option  granted  under  the 1996 ISO Plan and the  exercise  period  are
governed by the stock option agreement  between the holder of the option and the
Company. Subject to the limitations set forth in the 1996 ISO Plan, the terms of
such stock option  agreement,  including the exercise period,  are determined by
any of the  Committees or the Board and need not be uniform among  recipients of
similar  options.  Except  as set  forth in a stock  option  agreement,  options
granted  pursuant to the 1996 ISO Plan may be exercised only if the  participant
was, at all times during the period beginning on the date the option was granted
and ending on the date of such exercise,  an employee of the Company.  Except as
set forth in a stock  option  agreement or  otherwise  determined  by any of the
Committees or the Board,  the right to exercise any  unexercised  portion of any
option granted under the 1996 ISO Plan  terminates on the date of termination of
the employment  relationship  between the participant  and the Company,  for any
reason,  without  regard to cause,  other than by reason of death or disability.
Subject to such exception,  the option may not be exercised thereafter,  and the
shares of Common  Stock  subject to the  unexercised  portion of such option may
again be subject to new options under the 1996 ISO Plan.  Except as set forth in
a stock option agreement or otherwise determined by any of the Committees or the
Board, in the event a Participant dies or is disabled while he is an employee of
the  Company,  or any of its parents or  subsidiaries,  any options  theretofore
granted  to him shall be  exercisable  only  within  the 12  months  immediately
succeeding  such death or disability and then only (a) in the case of death,  by
the person or persons to whom the  Participant's  rights under such option shall
pass  by will  or the  laws of  descent  and  distribution,  and in the  case of
disability,  by such Participant or his legal representative,  and (b) if and to
the extent that he was entitled to exercise such option at the date of his death
or  disability.  The  maximum  option  term under the 1996 ISO Plan is ten years
after the date of grant.

New Plan Benefits

     Except as noted  below,  the  benefits or amounts  that will be received or
allocated in the future under the 1996 ISO Plan are not determinable.

U.S. Federal Income Tax Consequences

     The  following  is a summary of the U.S.  Federal  income tax  consequences
under  current tax law  (without  regard to any proposed  changes,  which may be
retroactive in effect) with respect to incentive  stock options  granted to U.S.
employees  under the 1996 ISO Plan.  For this  purpose,  it is assumed  that the
shares  acquired  pursuant to the exercise of an option are held by the optionee
as a capital asset. Certain other rules not discussed herein apply to the use of
previously  acquired  shares of Common  Stock in payment of the option  exercise
price.

     Incentive Stock Options.  In general,  no taxable income will be recognized
by an optionee  upon the grant or exercise of an  incentive  stock  option.  The
optionee's  tax basis in the shares  received on the  exercise of such an option
will be equal to the option price paid by the optionee for such shares.

     If the stock  received upon  exercise of an incentive  stock option is held
more than one year after the date of transfer of such shares to the optionee and
more  than two  years  from the  date of grant of the  option,  any gain or loss
recognized  by the  optionee  on the  subsequent  sale  of the  stock  will be a
long-term  capital gain or loss, as the case may be. If the shares received upon
the  exercise of an  incentive  stock option are disposed of prior to the end of
such holding periods, an amount equal to the excess (if any) of (a) the lower of
the  disposition  price or the fair  market  value of such shares on the date of
exercise of the incentive  stock option,  over (b) the  optionee's  tax basis in
such shares will be treated as ordinary  income,  and any further gain will be a
short-term or long-term  capital gain  depending upon the period the shares were
held.  Any  loss on the  disposition  of such  shares  will be a  short-term  or
long-term  capital  loss  depending  upon the period the  shares  were held.  In
general, any amounts treated as ordinary income will be allowed as an income tax
deduction to the Company.


                                       19
<PAGE>

     Cancellation or Surrender.  Consideration  received by an optionee upon the
surrender to, or cancellation  by, the Company of an incentive stock option will
be taxable as ordinary income to the optionee and generally allowed as an income
tax deduction to the Company.

     Alternative Minimum Tax. In addition to the Federal income tax consequences
described above, an optionee may be subject to the Federal  alternative  minimum
tax. In general, upon the exercise of any incentive stock option an amount equal
to the excess of the fair market  value of the shares  acquired on the  exercise
date over the  exercise  price  will be  treated  as an item of  adjustment  for
purposes of the alternative minimum tax. If, however, the shares are disposed of
in the same taxable year in which the exercise  occurs,  the maximum amount that
will be treated as an item of  adjustment  will be an amount equal to the excess
of the amount received upon such disposition over the exercise price.

     The  forgoing  does not  purport  to be a complete  summary of the  federal
income tax  considerations  that may be relevant to holders of options or to the
Company.  It also does not  reflect  provisions  of the  income  tax laws of any
municipality, state or foreign country in which an optionee may reside, nor does
it reflect the tax consequences of an optionee's death.

     The Board  recommends a vote "FOR"  approval of the  amendments to the 1996
ISO Plan to (i) increase the total number of shares of Common Stock which may be
issued  pursuant  to options  which may be granted  under the 1996 ISO Plan from
1,500,000 to 3,000,000, which number shall be reduced by the number of shares of
Common Stock which have been or may be issued  pursuant to options granted under
the 1996  Non-Qualified  Plan;  and (ii)  provide  that any of the  Compensation
Committee,  the Stock Option  Committee or the Board may administer the 1996 ISO
Plan and that such persons need not be "disinterested  persons" as such term was
formerly defined in Rule 16b-3  promulgated  under Section 16(b) of Exchange Act
(Proposal No. 2 on your proxy card).


                                       20
<PAGE>

                                 PROPOSAL NO. 3

         PROPOSED AMENDMENTS TO THE 1996 NON-QUALIFIED STOCK OPTION PLAN

     In February 1996, the Company's Board adopted the 1996  Non-Qualified  Plan
in order to enable the Company to attract and retain key advisors and  directors
and to promote  the  interests  of the  Company  by  affording  such  persons an
opportunity to acquire a proprietary  interest in the Company  pursuant to stock
options  issued by the  Company,  and thus to create in such  persons  increased
personal  interest  in  the  continued  success  of  the  Company.   Subject  to
shareholder   approval,   the  Board  has  approved   amendments   to  the  1996
Non-Qualified  Plan to (i)  increase  the total number of shares of Common Stock
which may be issued  pursuant  to options  which may be  granted  under the 1996
Non-Qualified Plan from 1,500,000 to 3,000,000, which number shall be reduced by
the number of shares which may be issued  pursuant to options  granted under the
1996 ISO Plan; (ii) provide that any of the  Compensation  Committee,  the Stock
Option  Committee or the Board may  administer the 1996  Non-Qualified  Plan and
such  persons  need not be  "disinterested  persons"  as such term was  formerly
defined in Rule 16b-3  promulgated  under the Exchange  Act;  (iii) provide that
members of the Board or any committee  administering the 1996 Non-Qualified Plan
are eligible to receive  discretionary  grants of options  thereunder;  and (iv)
clarify  that key  consultants  and  employees  in addition to key  advisors and
directors and employees of the Company are eligible to  participate  in the 1996
Non-Qualified Plan (Proposal No. 3 on your proxy card).

     The Board  believes  that a key  ingredient  in  attracting,  retaining and
motivating  key  consultants,  advisors,  directors  and  employees  is to offer
significant  potential  rewards  based upon the Company's  success,  through the
issuance  of  stock  options.  The  amendment  to the  1996  Non-Qualified  Plan
increasing the shares of Common Stock  authorized for issuance  presented herein
to the  stockholders  for their  approval  is  designed to assist the Company in
accomplishing  this goal.  Of the  1,500,000  shares of Common  Stock  currently
authorized under the 1996 ISO Plan and the 1996 Non-Qualified  Plan, at April 4,
1997 an aggregate of 446,228 shares remained available for future grants.

     The  following  summary  description  of the  1996  Non-Qualified  Plan  is
qualified in its entirety by the full text of the 1996  Non-Qualified  Plan,  as
proposed to be amended, which may be obtained by the Company's stockholders upon
request  to the  Secretary  of the  Company.  The  1996  Non-Qualified  Plan was
approved by the Board,  and subsequently by the  shareholders.  On April 3, 1997
the  amendments  discussed  herein have been  approved  by the Board  subject to
shareholder approval.

     The last sale price of a share of the Company's Common Stock as reported by
the Nasdaq National Market on April 4, 1997 was $5 1/8.

Description of the 1996 Non-Qualified Plan

     Administration of the 1996 Non-Qualified  Plan. The 1996 Non-Qualified Plan
as  originally  adopted  provided  that such plan be  administered  by the Stock
Option  Committee,  which  is a  subcommittee  of  the  Compensation  Committee,
comprised of not less than two persons to be appointed by the Board.  Other than
as recipients of non-discretionary  annual grants on each February 15th, members
of the  committee  were not  eligible  to  become  participants  under  the 1996
Non-Qualified  Plan  while  members  of the  committee  or for a period of three
months thereafter and were required,  unless otherwise  determined by the Board,
to be  "disinterested  persons" as such term was defined in Rule 16b-3 under the
Exchange Act.  Subject to shareholder  approval,  the Board has amended the 1996
Non-Qualified Plan to provide that any of the Compensation Committee,  the Stock
Option Committee  (collectively,  the  "Committees") or the Board may administer
the 1996  Non-Qualified  Plan  and  that  such  persons  administering  the 1996
Non-Qualified Plan need not be "disinterested persons" as such term was formerly
defined under Rule 16b-3. Further,  subject to shareholder  approval,  the Board
has amended the 1996  Non-Qualified Plan to provide that members of the Board or
any of the  Committees  are eligible to receive  discretionary  grants of awards
thereunder.  As discussed  above under  "Proposal No. 2," Rule 16b-3, as amended
now  gives  companies   greater   flexibility  in  administering   their  plans.
Accordingly,  subject to  shareholder  approval  the Board has  amended the 1996
Non-Qualified  Plan to take  advantage of this greater  flexibility  by removing
these  requirements as to  administration  and to permit members of the Board or
any  of  the  Committees  to  receive  discretionary  grants  thereunder.   Such
amendments  are  included  as  part  of  this  Proposal  No.  3 for  vote by the
shareholders at the Meeting.

     The members of the Committees serve at the pleasure of the Board, which has
the power at all times to remove  members from the  Committees or to add members
thereto.  Vacancies in the Committees,  however caused,  are filled by action of
the Board.  All decisions or  determinations  of the Committees or the Board are
made by the majority vote or decision of all of its members.  The 


                                       21
<PAGE>

interpretation  and  construction  by any of the  Committees or the Board of the
provisions of the 1996  Non-Qualified  Plan or of the options granted thereunder
are final unless otherwise determined by the Board.

     Eligibility to Participate in the 1996 Non-Qualified  Plan. It was intended
that the plan as  originally  adopted  provide that key  consultants,  advisors,
directors  and  employees  of the Company are  eligible for the grant of options
under the 1996 Non-Qualified Plan; however, such provision as to key consultants
and employees was somewhat unclear. The plan as originally adopted provided that
members of the Committees were ineligible to become  participants under the 1996
Non-Qualified Plan, except that they were permitted to receive non-discretionary
grants of options. This provision was necessary under former Rule 16b-3 in order
for the Stock Option Committee to be composed of "disinterested persons" as that
term was formerly defined in Rule 16b-3. As discussed above,  amendments to Rule
16b-3  eliminated  this  requirement  in order to  result  in  grant  and  award
transactions being exempt from Section 16(b). Accordingly, the Board, subject to
shareholder  approval,  has amended the 1996  Non-Qualified Plan to provide that
all  members  of  the  Board  and  the   Committees   are  eligible  to  receive
discretionary grants of options under the 1996 Non-Qualified Plan.  Furthermore,
subject to shareholder  approval,  the Board has amended the 1996  Non-Qualified
Plan to clarify that key consultants  and employees of the Company,  in addition
to key  advisors  and  directors,  are  eligible  to  participate  in  the  1996
Non-Qualified  Plan. Such amendments are included as part of this Proposal No. 3
for vote by the  shareholders at the Meeting.  Giving effect to the amendment to
the 1996  Non-Qualified  Plan expanding  persons eligible to participate,  as of
April 4, 1997,  approximately  105  persons,  plus any  consultants  or advisors
retained by the Company from time to time,  were eligible to  participate in the
1996 Non-Qualified Plan.

     Common Stock Subject to the 1996  Non-Qualified  Plan.  The original  total
number of shares  available to be issued under the 1996  Non-Qualified  Plan and
the 1996 ISO Plan was  1,500,000.  The Board has amended the 1996  Non-Qualified
Plan,  subject to  shareholder  approval,  to increase  such number of shares to
3,000,000. Such amendment is included as part of this Proposal No. 3 for vote by
the  shareholders  at the Meeting.  A similar  amendment to the 1996 ISO Plan is
being presented to  shareholders as part of Proposal No. 2, above.  The issuance
and sale of the shares of Common Stock currently authorized by the 1996 ISO Plan
and the 1996 Non-Qualified  Plan is covered by a Registration  Statement on Form
S-8 on file  with the  Commission;  provided  that  sales by  affiliates  of the
Company are subject to the volume  limitations  contained  in Rule 144 under the
Securities Act..

     If any  change is made in the  shares of Common  Stock  subject to the 1996
Non-Qualified Plan or subject to any option granted under the 1996 Non-Qualified
Plan (through merger,  consolidation,  reorganization,  recapitalization,  stock
dividend,  split-up,  combination  of shares,  exchange  of shares,  issuance of
rights to subscribe,  or change in capital structure),  appropriate  adjustments
shall be made by the  Committees or the Board as to the maximum number of shares
subject  to the 1996  Non-Qualified  Plan and the number of shares and price per
share subject to outstanding  options as shall be equitable to prevent  dilution
or enlargement of option rights.  Any such  determination made by the Committees
or the Board shall be final, binding and conclusive upon each participant.

     Amendments or Discontinuation of the 1996 Non-Qualified Plan. The Board may
make such amendments,  changes and additions to the 1996 Non-Qualified  Plan, or
may  discontinue  and  terminate  the 1996  Non-Qualified  Plan,  as it may deem
advisable  from time to time;  provided,  however,  that no action may affect or
impair any options  theretofore  granted under the 1996 Non-Qualified  Plan, and
provided,  further,  however,  that  the  affirmative  vote of the  owners  of a
majority of the outstanding shares of Common Stock present in person or by proxy
and entitled to vote thereon  shall be necessary to effect any  amendment to the
1996  Non-Qualified  Plan which  would  increase  the number of shares of Common
Stock subject to options granted under the 1996 Non-Qualified  Plan. In addition
to the requirement in the 1996 Non-Qualified Plan that the shareholders  approve
an  increase  in  shares  authorized  under  the 1996  Non-Qualified  Plan,  the
amendments  being presented  hereby to the  shareholders  for vote thereon,  are
being so presented for purposes of complying with Nasdaq National Market listing
requirements.

     ERISA. The 1996  Non-Qualified  Plan is not subject to any provision of the
Employee Retirement Income Security Act of 1974, as amended ("ERISA").

     Nontransferability. Options granted pursuant to the 1996 Non-Qualified Plan
are not  transferable  by the holder  thereof,  other than by will,  the laws of
descent and  distribution,  or (if  authorized  in the  applicable  Stock Option
Agreement)  pursuant to a qualified  domestic relations order, as defined by the
Code, or Title I of ERISA or the rules thereunder.

     Granting of Options. Any of the Committees or the Board shall determine the
key advisors,  directors and, subject to shareholder  approval,  key consultants
and  employees to be granted  options  under the 1996  Non-Qualified  Plan,  the
number of shares of Common Stock subject to such options, the exercise prices of
options,  the terms thereof and any other provisions not  inconsistent  with the
1996  Non-Qualified  Plan.  All  stock  options  granted  pursuant  to the  1996
Non-Qualified Plan shall be 


                                       22
<PAGE>

evidenced by stock option agreements,  which need not be identical,  between the
Company and the  participant  in such form as any of the Committees or the Board
shall from time to time approve,  subject to the terms of the 1996 Non-Qualified
Plan.  Each stock  option  agreement  shall state the total  number of shares of
Common  Stock  with  respect  to which  the  option  is  granted,  the terms and
conditions of the option, and the exercise price or prices thereof.

     The 1996 Non-Qualified Plan provides that annually,  on February 15 of each
of the Company's  fiscal  years,  any director of the Company who at the time is
not a full-time  employee of the Company (a "Participating  Director"),  will be
automatically   granted  an  option  for  2,500   shares  of  Common   Stock  (a
"Participating  Director  Option").  Each  person  who  becomes a  Participating
Director after the first day of the Company's fiscal year and within nine months
of that date will be granted,  on the date that person  becomes a  Participating
Director, a Participating Director Option for a number of shares of Common Stock
determined  by pro rating the normal  2,500  share  annual  amount  based on the
period of time  remaining  in the  fiscal  year in which such  person  becomes a
Participating  Director.  No  person,  who owns  10% or more of the  outstanding
Common  Stock of the Company  (including  shares of Common Stock  issuable  upon
exercise of  outstanding  options and warrants),  will be granted  Participating
Director Options.

     Life of the 1996 Non-Qualified  Plan. Options may be granted under the 1996
Non-Qualified Plan until February 25, 2006.

     Exercise  Price.  The price at which the shares of Common Stock  subject to
each option (other than  Participating  Director Options) granted under the 1996
Non-Qualified  Plan may be purchased  (the "option  price" or "exercise  price")
shall  be  determined  by any  of  the  Committees  or  the  Board  . Any of the
Committees  or the Board  shall  have the  authority  at the time the  option is
granted to  prescribe in any stock  option  agreement  that the price per share,
with the passage of  pre-determined  periods of time,  shall  increase  from the
original price to higher prices. Participating Director Options have an exercise
price  equal to the fair  market  value of the  Common  Stock on the date of the
grant.  The exercise price of all options  granted under the 1996  Non-Qualified
Plan is payable in full upon the exercise of such option, which payment shall be
in cash or stock  (that  has  been  owned by the  Participant  for at least  six
months)  or  notes  of  the  Company,  or,  as  agreed  to by the  Board,  other
consideration.

     Terms and Conditions of Exercise; Exercise Period. The terms and conditions
of any option granted under the 1996  Non-Qualified Plan and the exercise period
are governed by the stock option agreement  between the holder of the option and
the  Company.  Subject to the  limitations  set forth in the 1996  Non-Qualified
Plan, the terms of such stock option  agreement,  including the exercise period,
are  determined  by any of the  Committees  or the Board and need not be uniform
among  recipients  of  similar  options.  Except as set forth in a stock  option
agreement or otherwise determined by any of the Committees or the Board, options
(other  than  Participating  Director  Options)  granted  pursuant  to the  1996
Non-Qualified  Plan may be exercised only if the  Participant  was, at all times
during the period beginning on the date the option was granted and ending on the
date of such  exercise,  a  consultant,  advisor,  director  or  employee of the
Company. Except as set forth in a stock option agreement or otherwise determined
by any of the  Committees  or the Board,  the right to exercise any  unexercised
portion of any option (other than Participating Directors Options) granted under
the  1996  Non-Qualified  Plan  terminates  on the  date of  termination  of the
relationship  between the Participant and the Company,  for any reason,  without
regard to cause,  other than by reason of death or  disability.  Subject to such
exceptions, the option may not be exercised thereafter, and the shares of Common
Stock subject to the unexercised  portion of such option may again be subject to
new options under the 1996  Non-Qualified  Plan.  Except as set forth in a stock
option agreement or otherwise  determined by any of the Committees or the Board,
in the event a  Participant  dies or is disabled  while he is an advisor to or a
director  of the  Company,  any  options  (other  than  Participating  Directors
Options)  theretofore  granted to him shall be  exercisable  only  within the 12
months immediately  succeeding such death or disability and then only (a) in the
case of death, by the person or persons to whom the  Participant's  rights under
such option shall pass by will or the laws of descent and  distribution,  and in
the case of disability, by such Participant or his legal representative, and (b)
if and to the extent that he was entitled to exercise such option at the date of
his death or disability.  Participating  Director Options remain exercisable for
ten  years  after  the  date  of  grant  and the  option  holder  (or his  legal
representative  or that of his  estate)  may  continue  to  exercise  an  option
notwithstanding  that the  holder  ceases to be a  Participating  Director.  The
maximum  option  term under the 1996  Non-Qualified  Plan is ten years after the
date of grant.

New Plan Benefits

     The  benefits or amounts  that will be received or  allocated in the future
under the 1996 Non-Qualified Plan are not determinable.


                                       23
<PAGE>

U.S. Federal Income Tax Consequences

     The  following  is a summary of the U.S.  Federal  income tax  consequences
under  current tax law  (without  regard to any proposed  changes,  which may be
retroactive in effect) with respect to  non-qualified  stock options  granted to
U.S.  key  consultants,   advisors,  directors  and  employees  under  the  1996
Non-Qualified  Plan.  For this purpose,  it is assumed that the shares  acquired
pursuant  to the  exercise  of an option are held by the  optionee  as a capital
asset.  Certain  other rules not  discussed  here apply to the use of previously
acquired shares of Common Stock in payment of the option exercise price.

     Non-Qualified  Options. No taxable income will be recognized by an optionee
upon the grant of a non-qualified stock option. Upon the exercise of the option,
the excess of the fair market  value of the shares at the time of such  exercise
over the exercise price will be treated as compensation.  Any amounts treated as
compensation  (i) will be taxable as ordinary  income to the  optionee  and (ii)
generally  will be  allowed  as an income  tax  deduction  to the  Company.  The
optionee's  tax basis for shares  acquired  upon  exercise of the option will be
increased by any amounts so treated as compensation.

     Any gain or loss realized by an optionee on the  subsequent  sale of shares
acquired upon the exercise of a non-qualified stock option will be short-term or
long-term capital gain depending on the period the shares were held.

     Cancellation or Surrender.  Consideration  received by an optionee upon the
surrender to, or cancellation  by, the Company of a  non-qualified  stock option
will be taxable as ordinary  income to the optionee and generally  allowed as an
income tax deduction to the Company.

     The Board  recommends a vote "FOR"  approval of the  amendments to the 1996
Non-Qualified  Plan to (i)  increase  the total number of shares of Common Stock
which may be issued  pursuant  to options  which may be  granted  under the 1996
Non-Qualified Plan from 1,500,000 to 3,000,000, which number shall be reduced by
the number of shares of Common  Stock which have been or may be issued  pursuant
to  options  granted  under  the 1996 ISO  Plan;  (ii)  provide  that any of the
Compensation  Committee,  the Stock Option Committee or the Board may administer
the 1996  Non-Qualified  Plan and that such persons  need not be  "disinterested
persons" as such term was formerly defined in Rule 16b-3  promulgated  under the
Exchange  Act;  (iii)  provide  that  members  of the  Board  or  any  committee
administering the 1996 Non-Qualified Plan are eligible to receive  discretionary
grants of options  thereunder;  and (iv)  clarify that all key  consultants  and
employees of the Company are eligible to participate  in the 1996  Non-Qualified
Plan in addition to key advisors  and  directors  (Proposal  No. 3 on your proxy
card).


                                       24
<PAGE>

                                 PROPOSAL NO. 4

        PROPOSED AMENDMENT TO THE COMPANY'S CERTIFICATE OF INCORPORATION
           TO INCREASE THE NUMBER OF AUTHORIZED SHARES OF COMMON STOCK

     At present, the Company is authorized to issue two classes of capital stock
consisting  of Common  Stock  with a par value of $.001 per share and  Preferred
Stock with a par value of $1.00 per share (the  "Preferred  Stock").  30,000,000
shares of Common Stock and  4,000,000  shares of Preferred  Stock are  currently
authorized.  As of April 4, 1997,  there were 23,693,199  shares of Common Stock
issued  and  outstanding,  an  aggregate  of  2,152,098  shares of Common  Stock
reserved for issuance  pursuant to options issued and outstanding under the 1996
ISO Plan, the 1996 Non-Qualified  Plan, the 1986 Incentive Stock Option Plan and
the 1986  Non-Qualified  Stock Option Plan and 2,824,142  shares of Common Stock
reserved for issuance  pursuant to  outstanding  warrants.  Accordingly,  giving
effect to such issuances and reserves,  approximately 1,330,561 shares of Common
Stock remain available for issuance. If Proposal Nos. 2 or 3 described above are
approved by shareholders at the Meeting and this Proposal No. 4 is not approved,
the Company would have an  insufficient  number of  authorized  shares of Common
Stock  to  grant  all  options  permitted  under  the 1996 ISO Plan and the 1996
Non-Qualified Plan.

     The Board of  Directors  believes  that it is in the best  interests of the
Company  to  increase  the  authorized  number of shares  of Common  Stock  from
30,000,000 to  45,000,000,  and on April 3, 1997 the Board voted  unanimously to
submit to a vote of  stockholders  an amendment to the Company's  certificate of
incorporation  (the "Certificate of Incorporation") so increasing the authorized
Common Stock. The Company has no present agreement,  commitment,  plan or intent
to issue  any of the  additional  shares of Common  Stock  provided  for in this
Proposal. If this Proposal is approved,  the additional authorized Common Stock,
as  well as the  currently  authorized  but  unissued  Common  Stock,  would  be
immediately  available  in the future for such  corporate  purposes as the Board
deems  advisable from time to time without  further action by the  stockholders,
unless  such  action is  required  by  applicable  law or any stock  exchange or
securities market upon which the Company's shares may be listed.

     The additional  authorized Common Stock resulting from the approval of this
Proposal  will have the same  terms and  rights as the  existing  Common  Stock.
Holders of the Common  Stock of the  Company do not  presently  have  preemptive
rights nor will they as a result of the approval of this Proposal.

     The Board  anticipates that the authorized  Common Stock in excess of those
shares  outstanding  and reserved for issuance  (including,  if authorized,  the
additional  Common  Stock  provided for in this  Proposal)  will be utilized for
general corporate purposes,  including grants of stock options. These shares may
also be publicly  sold or  privately  placed by the Company as part of financing
transactions and may be utilized by the Company in connection with acquisitions,
commercial  agreements  and stock splits.  Such increase in shares also could be
used to make more  difficult  a change in  control  of the  Company.  Though the
Company  has no current  plan or  intention  to issue such  shares as a takeover
defense,  the additional  authorized shares could be used to discourage  persons
from  attempting  to gain  control  of the  Company or make more  difficult  the
removal of management.  Management is not currently aware of any specific effort
to  obtain  control  of  the  Company  by  means  of  a  merger,  tender  offer,
solicitation in opposition to management, or otherwise.

     It should be noted that, subject to the limitations discussed above, all of
the types of Board action described in the preceding paragraphs can currently be
taken and the power of the Board to take such  actions  would not be enhanced by
the passage of this  Proposal,  although this Proposal would increase the number
of shares of Common Stock that are subject to such action.

     If this  Proposal is  approved  and the  amendment  to the  Certificate  of
Incorporation  becomes  effective,  the first paragraph of Article Fourth of the
Company's Certificate of Incorporation, which sets forth the Company's presently
authorized capital stock, will be amended to read as set forth below.

     "FOURTH:  The  total  number  of shares  of  capital  stock  which the
     Corporation  shall have the authority to issue is  forty-five  million
     (45,000,000)  shares of common  stock with a par value of one tenth of
     one cent  ($.001)  per share and four  million  (4,000,000)  shares of
     preferred stock with a par value of one dollar ($1.00) per share."

     The  Board  recommends  a  vote  "FOR"  approval  of the  amendment  to the
Company's   Certificate  of  Incorporation  to  increase  the  total  number  of
authorized shares of Common Stock from 30,000,000 to 45,000,000  (Proposal No. 4
on your proxy card).


                                       25
<PAGE>

                                 PROPOSAL NO. 5

            RATIFICATION OF INDEPENDENT CERTIFIED PUBLIC ACCOUNTANTS

     The Board of Directors  has selected  KPMG Peat Marwick LLP as  independent
certified  public  accountants  for the Company for the year ending December 31,
1997. KPMG Peat Marwick LLP has served as the Company's  auditor since 1988. The
ratification of the selection of independent  certified public accountants is to
be voted upon at the Meeting,  and it is intended  that the persons named in the
accompanying proxy will vote for KPMG Peat Marwick LLP.  Representatives of KPMG
Peat Marwick LLP are expected to attend the Meeting,  to have an  opportunity to
make a  statement  if they  desire to do so and to be  available  to  respond to
appropriate questions.

     The Board recommends a vote "FOR" the selection of KPMG Peat Marwick to act
as the Company's  certified public  accountants for the year ending December 31,
1997 (Proposal No. 5 on your proxy card).

STOCKHOLDERS PROPOSALS

     A stockholder  proposal  intended to be presented at the  Company's  Annual
Meeting of Stockholders to he held in 1998 must be received by the Company on or
before  December  24,  1997 in  order  to be  included  in the  Company's  proxy
statement and form of proxy relating to that meeting.

GENERAL

     The cost of soliciting proxies will be borne by the Company. In addition to
the use of mails, proxies may be solicited by personal interview,  telephone and
telegraph,  and by  directors,  officers  and regular  employees of the Company,
without special compensation  therefor.  The Company expects to reimburse banks,
brokers  and  other  persons  for their  reasonable  out-of-pocket  expenses  in
handling proxy  materials for beneficial  owners of the Company's  Common Stock.
Additionally,  the Company has retained Corporate Communications Investors, Inc.
to assist in the solicitation of proxies for a fee of approximately $4,500, plus
expenses.

     Unless contrary instructions are indicated on the proxy card, all shares of
Common Stock represented by valid proxies received pursuant to this solicitation
(and not revoked  before  they are voted) will be voted FOR the  election of the
nominees for directors named herein, and FOR Proposals Nos. 2, 3, 4 and 5.

     Any proxy given pursuant to this  solicitation may be revoked by the person
giving it at any time  before it is voted.  Proxies may be revoked by the filing
with the Secretary of the Company  written notice of revocation  bearing a later
date than the proxy,  by duly executing a subsequent  proxy relating to the same
shares of  Common  Stock or by  attending  the  Meeting  and  voting in  person.
Attendance at the Meeting will not in and of itself  constitute  revocation of a
proxy unless the  stockholder  votes his or her shares of Common Stock in person
at the Meeting.  Any notice  revoking a proxy should be sent to the Secretary of
the Company,  John B. Landes, Esq. at ImClone Systems  Incorporated,  180 Varick
Street, Seventh Floor, New York, New York 10014.

     The Board  knows of no  business  other  than  that set  forth  above to be
transacted  at the  meeting,  but  if  other  matters  requiring  a vote  of the
stockholders  arise,  the persons  designated as proxies will vote the shares of
Common Stock  represented  by the proxies in accordance  with their  judgment on
such matters. If a stockholder specifies a different choice on the proxy, his or
her shares of Common Stock will be voted in accordance with the specification so
made.


                                       26

<PAGE>

     Please complete,  sign and date the enclosed proxy card, which is revocable
as described herein, and mail it promptly in the enclosed postage-paid envelope.


                                             By Order of the Board of Directors



                                             John B. Landes
                                             Secretary

New York, New York
April ___, 1997


     IT IS IMPORTANT THAT PROXIES BE RETURNED PROMPTLY.  WE URGE YOU TO FILL IN,
SIGN AND RETURN THE  ACCOMPANYING  PROXY CARD, NO MATTER HOW LARGE OR SMALL YOUR
HOLDINGS MAY BE.


                                       27
<PAGE>

                                                                      Appendix A

                          IMCLONE SYSTEMS INCORPORATED

Dear Shareholder:

Please take note of the important information enclosed with this Proxy Ballot.
There are a number of issues related to the management and operation of your
Company that require your immediate attention and approval. These are discussed
in detail in the enclosed proxy materials.

Your vote counts, and you are strongly encouraged to exercise your right to vote
your shares.

Please mark the boxes on the proxy card to indicate how your shares shall be
voted. Then sign the card, detach it and return your proxy vote in the enclosed
postage paid envelope.

Your vote must be received prior to the Annual Meeting of Shareholders, June 3,
1997.

Thank you in advance for your prompt consideration of these matters.

Sincerely,

ImClone Systems Incorporated


<PAGE>


     PLEASE MARK VOTES AS IN
  X  THIS EXAMPLE
 ---

1.) ELECTION OF DIRECTORS.   For: ____    Withheld: ____    For All Except: ____

Nominees:

Richard Barth              Jean Carvais
Vincent T. DeVita, Jr.     Robert F. Goldhammer
David M. Kies              Paul B. Kopperl
William R. Miller          Harlan W. Waksal
Samuel D. Waksal

If you do not wish your shares voted "FOR" a particular nominee, mark the "For
All Except" box and strike a line through that nominee(s) name. Your shares
shall be voted for the remaining nominee(s).

RECORD DATE SHARES:

2.)  To approve amendments to the 1996 Incentive Stock Option Plan (the "1996
     ISO Plan") to (i) increase the total number of shares of common stock,
     $.001 par value (the "Common Stock") which may be issued pursuant to
     options which may be granted under the 1996 ISO Plan from 1,500,000 to
     3,000,000, which number shall be reduced by the number of shares of Common
     Stock which have been or may be issued pursuant to options granted under
     the Company's 1996 Non-Qualified Stock Option Plan (the "1996 Non-Qualified
     Plan); and (ii) provide that any of the Compensation Committee, the Stock
     Option Committee or the Board of Directors (the "Board") may administer the
     1996 ISO Plan and that such persons need not be "disinterested persons" as
     such term was formerly defined in Rule 16b-3 promulgated under Section
     16(b) of the Securities Exchange Act of 1934, as amended (the "Exchange
     Act").

     For: ____                Against: ____              Abstain: ____

3.)  To approve amendments to the 1996 Non-Qualified Stock Option Plan to (i)
     increase the total number of shares of Common Stock which may be issued
     pursuant to options which may be granted under the 1996 Non-Qualified Plan
     from 1,500,000 to 3,000,000, which number shall be reduced by the number of
     shares of Common Stock which have been or may be issued pursuant to options
     granted under the 1996 ISO Plan; (ii) provide that any of the Compensation
     Committee, the Stock Option Committee or the Board may administer the 1996
     Non-Qualified Plan and that such persons need not be "disinterested
     persons" as such term was formerly defined in Rule 16b-3 promulgated under
     the Exchange Act; (iii) provide that members of the Board or any committee
     administering the 1996 Non-Qualified Plan are eligible to receive
     discretionary grants of options thereunder; and (iv) clarify that key
     consultants and employees of the Company are eligible to participate in the
     1996 Non-Qualified Plan in addition to key advisors and directors.

     For: ____                Against: ____              Abstain: ____

4.)  To approve an amendment to the Certificate of Incorporation to increase the
     authorized shares of Common Stock from 30,000,000 shares to 45,000,000
     shares.

     For: ____                Against: ____              Abstain: ____


<PAGE>

5.)  To ratify the selection by the Board of Directors of KPMG Peat Marwick as
     independent certified public accountant for the fiscal year ending 
     December 31, 1997.

     For: ____                Against: ____              Abstain: ____

6.)  To consider and act upon any other business as may come before the meeting
     or any adjournment thereof.

Please be sure to sign and date the Proxy.   Date:             
                                                               
                                             Mark box at right if comments _____
                                             or address change have been        
                                             noted on the reverse side of this  
                                             card.

_____________________________________________
Shareholder sign here      Co-owner sign here

Detach Card


<PAGE>

                          IMCLONE SYSTEMS INCORPORATED

               Proxy for the Meeting of Stockholders, June 3, 1997
           This Proxy is Solicited on Behalf of the Board of Directors

The undersigned hereby appoints Robert F. Goldhammer, John B. Landes and Samuel
D. Waksal as Proxies each with power of substitution and hereby authorizes each
of them to represent and to vote, as designated below, all the shares of Common
Stock of ImClone Systems Incorporated held of record by the undersigned on April
7, 1997 at the Annual Meeting of Stockholders to be held on June 3, 1997 or any
adjournment thereof.

PLEASE MARK, SIGN, DATE AND RETURN THIS PROXY TO STATE STREET BANK AND TRUST
COMPANY. THE COMPANY'S TRANSFER AGENT, TO BE RECEIVED NO LATER THAN MAY 15,

This Proxy when properly executed will be voted in the manner directed herein by
the undersigned stockholder. IF NO DIRECTION IS MADE, THIS PROXY WILL BE VOTED
FOR PROPOSAL 1,2,3,4,5, AND 6.

   PLEASE NOTE AND SIGN ON OTHER SIDE AND RETURN PROMPTLY IN ENCLOSED ENVELOPE

NOTE: Please sign exactly as name appears on this card. All joint owners should
sign. When signing as executor, administrator, attorney, trustee or guardian or
as custodian for a minor, please give full title as such. If a corporation,
please sign in full corporate name and indicate the signer's office. If a
partner, sign the partnership name.

HAS YOUR ADDRESS CHANGED?                   DO YOU HAVE ANY COMMENTS?

_______________________________             __________________________________
_______________________________             __________________________________
_______________________________             __________________________________


<PAGE>

                                                                      Appendix B

                          IMCLONE SYSTEMS INCORPORATED
                 1996 INCENTIVE STOCK OPTION PLAN, AS AMENDED(1)

                                    ARTICLE 1

                                 Purpose of Plan

     1.1 General Purpose. The purpose of this Incentive Stock Option Plan (the
"Plan") is to promote the interests of ImClone Systems Incorporated, and any
subsidiaries of such company, as from time to time may be formed or acquired
(collectively, the "Company"), by affording key executives and employees an
opportunity to acquire a proprietary interest in the Company pursuant to stock
options issued by the Company, and thus to create in such employees increased
personal interest in its continued success.

     1.2 Statutory Stock Option. Options granted under the Plan are intended to
be "incentive stock options" to which Section 422 of the Internal Revenue Code
of 1986, as amended (the "Code"), applies.

- ----------
(1)  This plan was adopted by the Board on February 25, 1996 and approved by the
     stockholders on June 3, 1996; it was amended by the Board on April 3, 1997
     and such amendments were ratified by the stockholders on ____, 1997.


                                       1
<PAGE>

                                   ARTICLE II

                             Shares Subject to Plan

     2.1 Description of Shares. Subject to Article VII hereof, the stock to
which the Plan applies is shares of the Company's common stock, $.001 par value
("Common Stock"), either authorized but unissued or Treasury shares. The number
of shares of Common Stock to be issued or sold pursuant to options granted
hereunder shall not exceed 3,000,000 shares; provided, that such number shall be
reduced by the number of shares which have been sold under, or may be sold
pursuant to options granted from time to time under, the Company's 1996
Non-Qualified Stock Option Plan (the "Non-Qualified Plan"), to the same extent
as if such sales had been made or options had been granted pursuant to this
Plan.

     2.2 Restoration of Unpurchased Shares. Any shares subject to an option
granted hereunder or under the Non-Qualified Plan that, for any reason, expires
or is terminated unexercised as to such shares may again be subject to an option
to be granted hereunder.

                                   ARTICLE III

                     Administration; Committees; Amendments

     3.1 Administration.. The Plan shall be administered by any of the
Compensation Committee, the Stock Option Committee (which is a subcommittee of
the Compensation Committee) (collectively, the "Committees") or the Company's
Board of Directors (the "Board"). The Committees shall be comprised of not less
than two persons who shall be 


                                       2
<PAGE>

appointed by the Board from among the members of the Board. Members of the
Committees shall not be eligible to become participants under the Plan while
they are members of the Committees or for a period of three months thereafter.

     3.2 Duration; Removal; Etc. The members of the Committees shall serve at
the pleasure of the Board, which shall have the power at all times to remove
members from the Committees or to add members thereto. Vacancies in the
Committees, however caused, shall be filled by action of the Board.

     3.3 Meetings; Actions of Committees. Each of the Committees and the Board
may select one of its members as its Chairman and shall hold its meetings at
such times and places as it may determine. All decisions or determinations of
each of the Committees and the Board shall be made by the majority vote or
decision of all of its members, whether present at a meeting or not; provided,
however, that any decision or determination reduced to writing and signed by all
of the members shall be as fully effective as if it had been made at a meeting
duly called and held. Each of the Committees and the Board may make such rules
and regulations for the conduct of its business not inconsistent herewith as it
may deem advisable.

     3.4 Interpretation. The interpretation and construction by any of the
Committees or the Board of the provisions of the Plan or of the options granted
hereunder shall be final, unless in the case of the Committees otherwise
determined by the Board. No member of the Board or of the Committees shall be
liable for any action taken or determination made in good faith.

     3.5 Amendments or Discontinuation. The Board may make such amendments,
changes, and additions to the Plan, or may discontinue and terminate the Plan,
as it may deem advisable 


                                       3
<PAGE>

from time to time; provided, however, that no action shall affect or impair any
options theretofore granted under the Plan, and provided, further, however, that
the affirmative vote of the owners of a majority of the outstanding shares of
Common Stock present at a meeting in person or by proxy and entitled to vote at
the meeting shall be necessary to effect any amendment to the Plan which would
(a) increase the number of shares of Common Stock subject to options granted
under the Plan, or (b) authorize the granting of options at a price below the
minimum price established by Section 5.3 hereof.

                                   ARTICLE IV

                  Participants; Maximum Grant; Duration of Plan

     4.1 Eligibility and Participation. Options shall be granted only to persons
("Participants") who at the time of granting are key executives or key employees
of the Company. Subject to the provisions of Section 4.3 hereof, the Committees
or the Board shall determine the key executives and key employees to be granted
options hereunder, the number of shares of Common Stock subject to such options,
the exercise prices of options, the terms thereof and any other provisions not
inconsistent with the Plan.
 
     4.2 Guidelines for Participation. In selecting Participants and determining
the numbers of shares of Common Stock for which options are to be granted the
Committees or the Board shall consult with officers and directors of the
Company, and shall take into account the duties of the respective employees,
their present and potential contributions to the success of the Company, and
such other factors as any of the Committees or the Board shall deem relevant.


                                       4
<PAGE>

     4.3 Maximum Grant. Notwithstanding anything to the contrary in the Plan,
the aggregate fair market value (determined as of the time the option is
granted) of the Common Stock for which any Participant may be granted options in
any calendar year (under all plans, including the Plan, providing for the grant
of incentive stock options of the Company and its parent and subsidiaries) shall
not exceed $100,000.

     4.4 Duration of Plan. All options under the Plan shall be granted within
ten years from the date the Plan is adopted, or the date the Plan is approved by
the shareholders of the Company, whichever is earlier.

                                    ARTICLE V

                         Terms and Conditions of Options

     5.1 Individual Stock Option Agreements. All stock options granted pursuant
to the Plan shall be evidenced by stock option agreements ("Stock Option
Agreements"), which need not be identical, between the Company and the
Participant in such form as any of the Committees or the Board shall from time
to time approve, subject to the terms of the Plan.

     5.2 Number of Shares. Each Stock Option Agreement shall state the total
number of shares of Common Stock with respect to which the option is granted,
the terms and conditions of the option, and the exercise price or prices
thereof, it being understood that any of the Committees or the Board shall have
authority to prescribe in any Stock Option Agreement that the option evidenced
thereby may be exercisable in full or in part, as to any number of shares
subject thereto, at any time or from time to time during the term of the option,
or in such 


                                       5
<PAGE>

installments at such times during said term as any of the Committees or the
Board may determine; provided that no option granted pursuant to the Plan shall
be exercisable after the expiration of ten years from the date such option is
granted. A previously granted incentive stock option shall be treated as
outstanding until it is exercised in full or expires by reason of the lapse of
time. Except as otherwise provided in any Stock Option Agreement, an option may
be exercised at any time or from time to time during the term of the option as
to any or all full (but no fractional) shares which have become purchasable
under such option. Any of the Committees or the Board shall have the right to
accelerate, in whole or in part, from time to time, conditionally or
unconditionally, the right to exercise any option granted hereunder.

     5.3 Option Price. The price at which the shares of Common Stock subject to
each option granted under this Plan may be purchased (the "option price" or
"exercise price") shall be determined by any of the Committees or the Board,
which shall have authority at the time the option is granted to prescribe in any
Stock Option Agreement that the price per share, with the passage of
pre-determined periods of time, shall increase from the original price to higher
prices, but in no case shall the original exercise price of any option be less
than 100% of the fair market value of such shares on the date the option is
granted, as determined by any of the Committees or the Board in accordance with
applicable Treasury Regulations. Notwithstanding anything contained to the
contrary herein, no option shall be granted to any employee who, at the time the
option is granted, owns more than 10% of the total combined voting power of all
classes of stock of the Company or of its parent or subsidiary unless, at the
time option is granted, the exercise price of the option is at least 110% of the
fair market value of the shares of Common Stock


                                       6
<PAGE>

subject to the option and such option by its terms is not exercisable after the
expiration of five years from the date such option is granted. For purposes of
determining the ownership of stock of the Company, the rules of Section 424(d)
of the Code shall be applied.

     5.4 Method of Exercising Option; Full Payment. Subject to Section 6.1 and
6.2 hereof, options granted pursuant to the Plan may be exercised only if the
Participant was, at all times during the period beginning on the date the option
was granted and ending on the date of such exercise, an employee of the Company,
a parent or subsidiary of the Company, or a corporation or a parent or
subsidiary of such corporation issuing or assuming a stock option in respect of
such option in a transaction to which Section 424(a) of the Code applies.
Options shall be exercised by written notice to the Company, addressed to the
Company at its principal place of business. Such notice shall state the
Participant's election to exercise the option and the number of shares of Common
Stock in respect of which it is being exercised, and shall be signed by the
Participant so exercising the option. Such notice shall be accompanied by (a)
the Stock Option Agreement (which, if not exercised for all the shares thereto,
shall be appropriately endorsed and returned to the Participant; (b) payment of
the full purchase price of such shares, which payment shall be in cash, by check
or in stock of the Company that has been owned by the participant for at least
six months, or notes of the Company or, as agreed to by the Board, other
consideration; and (c) such written representations and other documents as may
be desirable, in the opinion of the Company's legal counsel, for purposes of
compliance with state or Federal securities or other laws. In the case of
payment made in stock of the Company, the stock shall be valued at its Fair
Market Value (as hereinafter defined) on the last business day prior to the date


                                       7
<PAGE>

of exercise. The term "Fair Market Value" for the Common Stock on any particular
date shall mean the last reported sale price of the Common Stock on the
principal market on which the Common Stock trades on such date or, if no trades
of Common Stock are made or reported on such date, then on the next preceding
date on which the Common Stock traded. The Company shall deliver a certificate
or certificates representing shares of Common Stock purchased pursuant to such
notice to the purchaser as soon as practicable after receipt of such notice,
subject to Article VIII hereof. Any of the Committees or the Board may amend an
already outstanding Stock Option Agreement to add a provision permitted by
clause (b) of this Section 5.4, and no such amendment, by itself, shall be
deemed to constitute the grant of a new option for purposes of this Plan;
provided that this sentence shall not be determinative of whether any such
amendment constitutes a new grant for purposes of qualification as an Incentive
Stock Option.

     5.5 Rights as a Shareholder. No Participant shall have any rights as a
shareholder with respect to shares of Common Stock subject to an option granted
under the Plan until the date of the issuance to such Participant of stock
certificates in respect of such shares. No adjustment shall be made for
dividends or other rights for which the record date is prior to the date such
stock certificate is issued.

     5.6 Other Provisions. Stock Option Agreements entered into pursuant to the
Plan may contain such other provisions (not inconsistent with the Plan) as any
of the Committees or the Board may deem necessary or desirable, including, but
not limited to, covenants on the part of the Participant not to compete, not to
sell Common Stock obtained from the exercise of


                                       8
<PAGE>

options for specified periods of time, and remedies available to the Company in
the event of the breach of any such covenant.

                                   ARTICLE VI

                   Termination of Employment; Transferability

     6.1 Termination of Employment. Except as otherwise provided in connection
with the grant of any option or the termination of any Participant, the right to
exercise any unexercised portion of any option granted under the Plan shall
terminate immediately upon termination of the employment relationship between
the Participant and the Company (or its parent or subsidiary, as the case may
be), for any reason, without regard to cause, other than by reason that the
Participant dies or becomes disabled (as defined in the Code). The option may
not be exercised thereafter, and the shares of Common Stock subject to the
unexercised portion of such option may again be subject to new options under the
Plan.

     6.2 Death or Disability of Participant. Except as otherwise permitted in
connection with the grant of any option or the death or disability of a
Participant, in the event a Participant dies or is disabled while in the employ
of the Company or of a parent or subsidiary of the Company, any options
theretofore granted to him shall be exercisable only within the next 12 months
immediately succeeding such death or disability and then only in the case of
death (a) by the person or persons to whom the Participant's rights under the
option shall pass by will or the laws of descent and distribution, and, in the
case of disability, by such Participant or his legal 


                                       9
<PAGE>

representative, and (b) if and to the extent that he was entitled to exercise
the option at the date of his death.

     6.3 Transferability. Options granted to a Participant under the Plan shall
not be transferable otherwise than by will, by the laws of descent and
distribution, or (if authorized in the applicable Stock Option Agreement)
pursuant to a qualified domestic relations order ("QDRO") as defined by the
Internal Revenue Code of 1986, as amended, or Title I of the Employee Retirement
Income Security Act of 1974, as amended, or the rules thereunder. During the
Participant's lifetime, options shall be exercised only by such Participant,
such Participant's guardian or legal representative, or (if authorized in the
applicable Stock Option Agreement) such Participant's transferee pursuant to a
QDRO.

                                   ARTICLE VII

                               Capital Adjustments

     7.1 Capital Adjustments. If any change is made in the shares of Common
Stock subject to the Plan or subject to any option granted under the Plan
(through merger, consolidation, reorganization, recapitalization, stock
dividend, split-up, combination of shares, exchange of shares, issuance of
rights to subscribe, or change in capital structure), appropriate adjustments
shall be made by any of the Committees or the Board as to the maximum number of
shares subject to the Plan and the number of shares and price per share subject
to outstanding options as shall be equitable to prevent dilution or enlargement
of option rights; provided, however, that any such adjustment shall comply with
the rules of Section 424(a) of the Code and provided 


                                       10
<PAGE>

further that in no event shall any adjustment be made that would cause any
option granted hereunder to be considered other than an incentive stock option.
Any determination made by any of the Committees or the Board under this Article
VII shall be final, binding and conclusive upon each Participant.

                                  ARTICLE VIII

                            Legal Requirements, Etc.

     8.1 Revenue Stamps. The Company shall be responsible and shall pay for any
transfer, revenue, or documentary stamps with respect to shares issued upon the
exercise of options granted under the Plan.

     8.2 Legal Requirements. The Company shall not be required to issue
certificates for shares upon the exercise of any option unless and until, in the
opinion of the Company's legal counsel, such issuance would not result in a
violation of any state or Federal securities or other law. Certificates for
shares, when issued, shall have, if required in the opinion of the Company's
legal counsel, the following legend, or statements of other restrictions,
endorsed thereon, and may not be immediately transferable:

     The shares of Common Stock evidenced by this certificate have been issued
     to the registered owner in reliance upon written representations that these
     shares have been purchased for investment. These shares may not be sold,
     transferred, or assigned unless, in the opinion of the Company and its
     legal counsel, such sales, transfer, or assignment will not be in violation
     of the Securities Act of 1933, as amended, applicable rules and regulations
     of the Securities and Exchange Commission and any applicable state
     Securities laws.


                                       11
<PAGE>

     8.3 Private Offering. The options to be granted under the Plan are
available only to a limited number of present and future key executives and
employees of the Company and its subsidiaries who have knowledge of the
Company's financial condition, management, and affairs. Such options are not
intended to provide additional capital for the Company but are to encourage
stock ownership by the Company's key personnel. By the act of accepting an
option, in the absence of an effective registration statement under the
Securities Act of 1933, as amended, Participants shall agree that upon exercise
of such option, they will acquire the shares of Common Stock that are the
subject thereof for investment and not with any intention at such time to resell
or redistribute the same, and they shall confirm such agreement at the time of
exercise, but the neglect or failure to confirm the same in writing shall not be
a limitation of such agreement.

                                   ARTICLE IX

                                     General

     9.1 Application of Funds. The proceeds received by the Company from the
sale of shares of Common Stock pursuant to the exercise of options therefor
shall be used for general corporate purposes.

     9.2 Right of the Company to Terminate Employment. Nothing contained in the
Plan or in a Stock Option Agreement shall confer upon any Participant any right
to be continued in the employ of the Company or of any subsidiary of the
Company, or interfere in any way with the 


                                       12
<PAGE>

right of the Company, or such subsidiary, to terminate his employment for any
reason whatsoever, with or without cause, at any time.

     9.3 No Obligation to Exercise. The granting of an option hereunder shall
impose no obligation upon the Participant to exercise such option.

     9.4 Effectiveness of Plan. The Plan shall become effective upon its
adoption by the shareholders of the Company. Options may be granted under the
Plan prior to the approval of the Plan by the Shareholders, but no such option
may be exercised prior to such approval.

     9.5 Other Benefits. Participation in the Plan shall not preclude a
Participant from eligibility in any other stock benefit plan of the Company or
any old age benefit, insurance, pension, profit sharing, retirement, bonus or
other plan which the Company has adopted, or may, at any time, adopt for the
benefit of its parents' or its subsidiaries' executives and/or employees.

     9.6 Company Records. Records of the Company as to a Participant's period of
employment, termination of employment and the reason therefor, leaves of
absence, re-employment, and other matters will be conclusive for all purposes
hereunder.

     9.7 Tax Requirement. The exercise or surrender of any option under this
Plan shall constitute a Participant's full and complete consent to whatever
action the Committee elects to satisfy the Federal and state withholding
requirements, if any, which the Committee in its discretion deems applicable to
such exercise.

     9.8 Interpretations and Adjustments. To the extent permitted by law, an
interpretation of the Plan and a decision on any matter within any of the
Committees' or Board's discretion made in good faith is binding on all persons.
A misstatement or other mistake of fact shall be 


                                       13
<PAGE>

corrected when it becomes known, and the person responsible shall make such
adjustment on account thereof as he considers equitable and practicable.

     9.9 Information. The Company shall, upon request or as may be specifically
required hereunder, furnish or cause to be furnished, all of the information or
documentation which is necessary or required by any of the Committees or the
Board to perform its duties and functions under the Plan.

     9.10 Notice of Disqualifying Disposition. If a Participant sells or
otherwise disposes of any share of Common Stock transferred to him pursuant to
the exercise of an option granted hereunder within two years from the date of
the granting of the option or within one year of the transfer of such shares to
him (i.e., a "disqualifying disposition"), the Participant, within ten days
thereafter, shall furnish to any of the Committees or the Board at the principal
offices of the Company, written notice of such sale or other disposition.

     9.11 Governing Law. The Plan and any and all options granted thereunder
shall be governed by, and construed and enforced in accordance with, the laws of
the State of New York from time to time in effect.

     9.12 Certain Definitions.

          9.12.1 "Parent". The term "parent" shall mean a "parent corporation"
as defined in Section 424(e) of the Code.

          9.12.2 "Subsidiary". The term "subsidiary" shall mean a "subsidiary
corporation" as defined in Section 424(f) of the Code.


                                       14
<PAGE>

          9.12.3 "Incentive Stock Option". The term "incentive stock option"
shall mean an option described in Section 422(b) of the code.

          9.12.4 "Disabled." The term "disabled" shall have the definition set
forth in Section 22(a)(3) of the Code.


                                       15
<PAGE>

                                                                      Appendix C

                          IMCLONE SYSTEMS INCORPORATED

               1996 NON-QUALIFIED STOCK OPTION PLAN, AS AMENDED(1)

                                    ARTICLE I

                                 Purpose of Plan

     1.1 General Purpose. The purpose of this Non-Qualified Stock Option Plan
(the "Plan") is to promote the interests of ImClone Systems Incorporated (the
"Company") by affording key consultants, advisors, directors and employees an
opportunity to acquire a proprietary interest in the Company pursuant to stock
options issued by the Company, and thus to create in such persons increased
personal interest in its continued success.

     1.2 Statutory Stock Option. Options granted under the Plan are intended to
be "non-qualified" stock options under the Internal Revenue Code of 1986, as
amended (the "Code").

                                   ARTICLE II

                             Shares Subject to Plan

     2.1 Description of Shares. Subject to Article VIII hereof, the stock to
which the Plan applies is shares of the Company's common stock, $.001 par value
("Common Stock"), either

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(1)  This plan was adopted by the Board on February 25, 1996 and approved by the
     stockholders on June 3, 1996; it was amended by the Board on April 3, 1997
     and such amendments were ratified by the stockholders on _________, 1997.


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authorized but unissued or Treasury shares. The number of shares of Common Stock
to be issued or sold pursuant to options granted hereunder shall not exceed
3,000,000 shares; provided, that such number shall be reduced by the number of
shares which have been sold under, or may be sold pursuant to options granted
from time to time under, the Company's 1996 Incentive Stock Option Plan (the
"Incentive Stock Option Plan") to the same extent as if such sales had been made
or options had been granted pursuant to this Plan.

     2.2 Restoration of Unpurchased Shares. Any shares subject to an option
granted hereunder that, for any reason, expires or is terminated unexercised as
to such shares may again be subject to an option to be granted hereunder.

                                   ARTICLE III

                     Administration; Committees; Amendments

     3.1 Administration. The Plan shall be administered by any of the
Compensation Committee, the Stock Option Committee (which is a subcommittee of
the Compensation Committee) (collectively, the "Committees") or the Board of
Directors of the Company (the "Board"). The Committees shall be comprised of not
less than two persons who shall be appointed by the Board from among the members
of the Board. Members of the Committees and the Board shall be eligible to
become participants under the Plans and may receive discretionary and
non-discretionary grants of options.

     3.2 Duration; Removal; Etc. The members of the Committees shall serve at
the pleasure of the Board, which shall have the power at all times to remove
members from the 


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Committees or to add members thereto. Vacancies in the Committees, however
caused, shall be filled by action of the Board.

     3.3 Meetings; Actions of Committee. Each of the Committees may select one
of its members as its Chairman and shall hold its meetings at such times and
places as it may determine. All decisions or determinations of the Committees
and the Board shall be made by the majority vote or decision of all of its
members, whether present at a meeting or not; provided, however, that any
decision or determination reduced to writing and signed by all of the members
shall be as fully effective as if this had been made at a meeting duly called
and held. Each of the Committees and the Board may make such rules and
regulations for the conduct of its business not inconsistent herewith as it may
deem advisable.

     3.4 Interpretation. The interpretation and construction by any of the
Committees or the Board of the provisions of the Plan or of the options granted
hereunder shall be final, unless in the case of the Committees otherwise
determined by the Board. No member of the Board or of the Committees shall be
liable for an action taken or determination made in good faith.

     3.5 Amendments or Discontinuation. The Board may make such amendments,
changes, and additions to the Plan, or may discontinue and terminate the Plan,
as it may deem advisable from time to time; provided, however, that no action
shall affect or impair any options theretofore granted under the Plan, and
provided, further, however, that the affirmative vote of the owners of a
majority of the outstanding shares of Common Stock present at a meeting in
person or by proxy and entitled to vote shall be necessary to effect any
amendment to the Plan 


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<PAGE>

which would increase the number of shares of Common Stock subject to options
granted under the Plan.

                                   ARTICLE IV

                  Participants; Maximum Grant; Duration of Plan

     4.1 Eligibility and Participation. Options shall be granted only to persons
("Participants") who at the time of granting are key consultants, advisors,
directors or employees of the Company. Any of the Committees or the Board shall
determine the key consultants, advisors, directors and employees to be granted
options hereunder, the number of shares of Common Stock subject to such options,
the exercise prices of options, the terms thereof and any other provisions not
inconsistent with the Plan.

     4.2 Guidelines for Participation. In selecting Participants and determining
the numbers of shares of Common Stock for which options are to be granted, any
of the Committees or the Board shall consult with officers and directors of the
Company, and shall take into account the duties of the respective persons, their
present and potential contributions to the success of the Company, and such
other factors as any of the Committees or the Board shall deem relevant.

     4.3 Duration of Plan. All options under the Plan shall be granted within
ten years from the date the Plan is approved by the shareholders of the Company.


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<PAGE>

                                    ARTICLE V

                         Terms and Conditions of Options

     5.1 Individual Stock Option Agreements. All stock options granted pursuant
to the Plan shall be evidenced by stock option agreements ("Stock Option
Agreements"), which need not be identical, between the Company and the
Participant in such form as any of the Committees or the Board shall from time
to time approve, subject to the terms of the Plan.

     5.2 Number of Shares. Each Stock Option Agreement shall state the total
number of shares of Common Stock with respect to which the option is granted,
the terms and conditions of the option, and the exercise price or prices
thereof, it being understood that any of the Committees or the Board shall,
subject to the terms of Article VII hereof, have authority to prescribe in any
Stock Option Agreement that the option evidenced thereby may be exercisable in
full or in part, as to any number of shares subject thereto, at any time or from
time to time during said term as any of the Committees or the Board may
determine; provided that no option granted pursuant to the Plan shall be
exercisable after the expiration of ten years from the date such option is
granted. Except as otherwise provided in any Stock Option Agreement, an option
may be exercised at any time or from time to time during the term of the option
as to any or all full (but no fractional) shares which have become purchasable
under such option. Subject to the terms of Article VII hereof, any of the
Committees or the Board shall have the right to accelerate, in whole or in part,
from time to time, conditionally or unconditionally, the right to exercise any
option granted hereunder.


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<PAGE>

     5.3 Option Price. Subject to the terms of Article VII hereof, the price at
which the shares of Common Stock subject to each option granted under this Plan
may be purchased (the "option price" or "exercise price") shall be determined by
any of the Committees or the Board, which shall have the authority at the time
the option is granted to prescribe in any Stock Option Agreement that the price
per share, with the passage of pre-determined periods of time, shall increase
from the original price to higher prices.

     5.4 Method of Exercising Option; Full Payment. Subject to the terms of
Article VII hereof and Section 6.1 and Section 6.2 hereof, options granted
pursuant to the Plan may be exercised only if the Participant was, at all times
during the period beginning on the date the option was granted and ending on the
date of such exercise, a key consultant, advisor, director or employee of the
Company. Options shall be exercised by written notice to the Company, addressed
to the Company at its principal place of business. Such notice shall state the
Participant's election to exercise the option and the number of shares of Common
Stock in respect of which it is being exercised, and shall be signed by the
Participant so exercising the option. Such notice shall be accompanied by (a)
the Stock Option Agreement (which, if not exercised for all the shares subject
thereto, shall be appropriately endorsed and returned to the Participant); (b)
payment of the full purchase price of such shares, which payment shall be in
cash, by check or in stock of the Company that has been owned by the Participant
for at least six months, or notes of the Company or, as agreed to by the Board,
other consideration; and such written representations and other documents as may
be desirable, in the opinion of the Company's legal counsel, for purposes of
compliance with state or Federal securities or other 


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laws. In the case of payment made in stock of the Company, the stock shall be
valued at its Fair Market Value (as hereinafter defined) on the last business
day prior to the date of exercise. The term "Fair Market Value" for the Common
Stock on any particular date shall mean the last reported sale price of the
Common Stock on the principal market on which the Common Stock trades on such
date or, if no trades of Common Stock are made or reported on such date, then on
the next preceding date on which the Common Stock traded. The Company shall
deliver a certificate or certificates representing shares of Common Stock
purchased pursuant to such notice to the purchaser as soon as practicable after
receipt of such notice, subject to Article IX hereof. Any of the Committees or
the Board may amend an already outstanding Stock Option Agreement to add a
provision permitted by clause (b) of this Section 5.4, and no such amendment, by
itself, shall be deemed to constitute the grant of a new option for purposes of
this Plan.

     5.5 Rights as a Shareholder. No Participant shall have any rights as a
shareholder with respect to shares of Common Stock subject to an option granted
under the Plan until the date of the issuance to such Participant of a stock
certificate in respect of such shares. No adjustment shall be made for dividends
or other rights for which the record date is prior to the date such stock
certificate is issued.

     5.6 Other Provisions. Stock Option Agreements entered into pursuant to the
Plan may contain such other provisions (not inconsistent with the Plan) as any
of the Committees or the Board may deem necessary or desirable, including, but
not limited to, covenants on the part of the Participant not to compete, not to
sell Common Stock obtained from the exercise of 


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<PAGE>

options for specified periods of time, and remedies available to the Company in
the event of the breach of any such covenant.

                                   ARTICLE VI

                          Termination; Transferability

     6.1 Termination. Except as otherwise provided in connection with the grant
of any option or the termination of any Participant, the right to exercise any
unexercised portion of any option granted under the Plan shall terminate on the
date of termination of the relationship between the Participant and the Company,
for any reason, without regard to cause, other than by reason of death or
disability. The option may not be exercised thereafter, and the shares of Common
Stock subject to the unexercised portion of such option may again be subject to
new options under the Plan. Such restrictions shall not apply to the options
granted pursuant to Article VII which shall be exercisable in accordance with
the terms thereof.

     6.2 Death or Disability of Participant. Except as otherwise permitted in
connection with the grant of any option or the death or disability of a
Participant, in the event a Participant dies or is disabled while he is a
consultant, advisor, director or employee of the Company, any options
theretofore granted to him shall be exercisable only within the next 12 months
immediately succeeding such death or disability and then only (a) in the case of
death, by the person or persons to whom the Participants rights under the option
shall pass by will or the laws of descent and distribution, and in the case of
disability, by such Participant or his legal representative, and (b) if and to
the extent that he was entitled to exercise the option at the date of 


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<PAGE>

his death or disability. Such restrictions shall not apply to the options of
Participating Directors which shall be exercisable in accordance with the terms
set forth in Article VII hereof.

     6.3 Transferability. Options granted to a Participant under the Plan shall
not be transferable otherwise than by will, by the laws of descent and
distribution, or (if authorized in the applicable Stock Option Agreement)
pursuant to a qualified domestic relations order ("QDRO") as defined by the
Internal Revenue Code of 1986, as amended, or Title I of the Employee Retirement
Income Security Act of 1974, as amended, or the rules thereunder. During the
Participant's lifetime, options shall be exercised only by such Participant,
such Participant's guardian or legal representative, or (if authorized in the
applicable Stock Option Agreement) such Participant's transferee pursuant to a
QDRO.

                                   ARTICLE VII

                                Directors' Grants

     7.1 Eligibility. Annually, on February 15 of each of the Company's Fiscal
Years, any Director of the Company who at the time is not a full-time employee
of the Company (a "Participating Director"), shall be granted an option for
2,500 shares of Common Stock. Each person who becomes a Participating Director
after the first day of the Company's fiscal year and within nine months of that
date shall be granted, on the date that person becomes a Participating Director,
an option for a number of shares of Common Stock determined by pro rating the
normal 2,500 share annual amount based on the period of time remaining in the
fiscal year in which such person becomes a Participating Director. No person who
owns 10% or more of the 


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<PAGE>

outstanding Common Stock of the Company (including shares of Common Stock
issuable upon exercise of outstanding options and warrants), shall be granted
options under this Article. Options under this Article are non-discretionary.

     7.2 Options Terms. Options granted under this Article VII shall not be
exercisable until the date upon which the option holder has provided one year of
continuous service as a Participating Director following the date of grant of
such option. Options granted pursuant to this Article shall have an exercise
price equal to the Fair Market Value (as hereinafter defined) of the Common
Stock on the date of the grant. The term "Fair Market Value" for the Common
Stock on any particular date shall mean the last reported sale price of the
Common Stock on the principal market on which the Common Stock trades on such
date or, if no trades of Common Stock are made or reported on such date, then on
the next preceding date on which the Common Stock traded. Notwithstanding any
other provisions of this Plan, options granted under this Article shall remain
exercisable for ten years after the date of grant and the option holder (or his
legal representative or that of his estate) may continue to exercise an option
notwithstanding that the holder ceases to be a Participating Director.

     7.3 Other Provisions. In all other respects, Options granted under this
Article VII shall be subject to the other provisions of the Plan, including but
not limited to those governing method of exercise, exercise payment, tax
withholding, and transferability. Notwithstanding any other provisions of this
Plan, the provisions of this Article VII may not be amended more than once every
six months, other than to comport with changes in the Code.


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<PAGE>

                                  ARTICLE VIII

                               Capital Adjustments

     8.1 Capital Adjustments. If any change is made in the shares of Common
Stock subject to the Plan or subject to any option granted under the Plan
(through merger, consolidation, reorganization, recapitalization, stock
dividend, split-up, combination of shares, exchange of shares, issuance of
rights to subscribe, or change in capital structure), appropriate adjustments
shall be made by any of the Committees or the Board as to the maximum number of
shares subject to the Plan and the number of shares and price per share subject
to outstanding options as shall be equitable to prevent dilution or enlargement
of option rights. Any determination made by any of the Committees or the Board
under this Article VIII shall be final, binding and conclusive upon each
Participant.

                                   ARTICLE IX

                            Legal Requirements, Etc.

     9.1 Revenue Stamps. The Company shall be responsible and shall pay for any
transfer, revenue, or documentary stamps with respect to shares issued upon the
exercise of options granted under the Plan.

     9.2 Legal Requirements. The Company shall not be required to issue
certificates for shares upon the exercise of any option unless and until, in the
opinion of the Company's legal counsel, such issuance would not result in a
violation of any state or Federal securities or other law. Certificates for
shares, when issued, shall have, if required in the opinion of the Company's


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<PAGE>

legal counsel, the following legend, or statements of other restrictions,
endorsed thereon, and may not immediately be transferable:

     The shares of Common Stock evidenced by this certificate have been issued
     to the registered owner in reliance upon written representations that these
     shares have been purchased for investment. These shares may not be sold,
     transferred, or assigned unless, in the opinion of the Company and its
     legal counsel, such sale, transfer, or assignment will not be in violation
     of the Securities Act of 1933, as amended, applicable rules and regulations
     of the Securities and Exchange Commission and any applicable state
     securities laws.

     9.3 Private Offering. The options to be granted under the Plan are
available only to a limited number of present and future key consultants,
advisors, directors and employees of the Company who have knowledge of the
Company's financial condition, management, and affairs. Such options are not
intended to provide additional capital for the Company, but are to encourage
stock ownership by the Company's key personnel. By the act of accepting an
option, in the absence of an effective registration statement under the
Securities Act of 1933, as amended, Participants shall agree that upon exercise
of such option, they will acquire the shares of Common Stock that are the
subject thereof for investment and not with any intention at such time to resell
or redistribute the same, and they shall confirm such agreement at the time of
exercise, but the neglect or failure to confirm the same in writing shall not be
a limitation of such agreement.


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<PAGE>

                                    ARTICLE X

                                     General

     10.1 Application of Funds. The proceeds received by the Company from the
sale of shares of Common Stock pursuant to the exercise of options therefor
shall be used for general corporate purposes.

     10.2 Right of the Company to Terminate Relationship. Nothing contained in
the Plan or in a Stock Option Agreement shall confer upon any Participant any
right to be continued as a consultant, advisor, director or employee of the
Company, or interfere in any way with the right of the Company to terminate such
relationship for any reason whatsoever, with or without cause, at any time.

     10.3 No Obligation to Exercise. The granting of an option hereunder shall
impose no obligation upon the Participant to exercise such option.

     10.4 Effectiveness of Plan. The Plan shall become effective upon its
adoption by the Board. Options may be granted under the Plan prior to the
approval of the Plan by the Shareholders, but no such option may be exercised
prior to such approval.

     10.5 Other Benefits. Participation in the Plan shall not preclude a
Participant from eligibility in any other stock benefit plan of the Company or
any old age benefit, insurance, pension, profit sharing, retirement, bonus or
other plan which the Company has adopted, or may, at any time, adopt.

     10.6 Tax Requirements. The exercise or surrender of any option under this
Plan shall constitute a Participant's full and complete consent to whatever
action any of the Committees or 


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<PAGE>

the Board elect to satisfy the Federal and state withholding requirements, if
any, which the Committee in its discretion deems applicable to such exercise.

     10.7 Interpretations and Adjustments. To the extent permitted by Law, an
interpretation of the Plan and a decision on any matter within any of the
Committees' or the Board's discretion made in good faith is binding on all
persons. A misstatement or other mistake of fact shall be corrected when it
becomes known, and the person responsible shall make such adjustment on account
thereof as he considers equitable and practicable.

     10.8 Information. The Company shall, upon request or as may be specifically
required hereunder, furnish or cause to be furnished, all of the information or
documentation which is necessary or required by any of the Committees or the
Board to perform its duties and functions under the Plan.

     10.9 Governing Law. The Plan and any and all options granted thereunder
shall be governed by, and construed and enforced in accordance with, the laws of
the State of New York from time to time in effect.

     10.10 Certain Definitions.

          10.10.1 "Parent". The term "parent" shall mean a "parent corporation"
as defined in Section 424(e) of the Code.

          10.10.2 "Subsidiary". The term "subsidiary" shall mean a "subsidiary
corporation" as defined in Section 424(f) of the Code.

          10.10.3 "Disabled". The term "disabled" shall have the definition set
forth in Section 22(a) (3) of the Code.


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