IMCLONE SYSTEMS INC/DE
DEF 14A, 1999-04-23
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                            SCHEDULE 14A INFORMATION
                    Proxy Statement Pursuant to Section 14(a)
                     of the Securities Exchange Act of 1934
                               (Amendment No. __ )

Filed by the Registrant [x]
Filed by a Party other than the Registrant [ ]
Check the appropriate box:
[ ] Preliminary Proxy Statement
[ ] Confidential, for Use of the Commission Only
    (as permitted by Rule  14a-6(e)(2))
[X] Definitive Proxy Statement
[ ] Definitive Additional Materials
[ ] Soliciting Material Pursuant to ss.240.14a-11(c) or  ss.240.14a-12

                          Imclone Systems Incorporated.
                (Name of Registrant as Specified In Its Charter)
    ______________________________________________________________________
    (Name of Person)s) Filing Proxy Statement if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):

[x]  No fee Required.
[ ]  Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.

       1) Title of each class of securities to which transaction applies:

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       2) Aggregate number of securities to which transaction applies:

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       3) Per unit  price  or other  underlying  value of  transaction  computed
pursuant to Exchange Act Rule 0-11 (Set forth the amount on which the filing fee
is calculated and state how it was determined):

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       4) Proposed maximum aggregate value of transaction:

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       5) Total fee paid:

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[ ]  Fee paid previously with preliminary materials.

[ ]  Check box if any part of the fee is offset as provided by Exchange Act Rule
0-11(a)(2)  and  identify  the  filing  for  which the  offsetting  fee was paid
previously.  Identify the previous filing by registration  statement  number, or
the Form or Schedule and the date of its filing

       1) Amount previously paid:

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       2) Form, Schedule or Registration Statement No.:

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       3) Filing Party:

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       4) Date Filed:

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<PAGE>

                          IMCLONE SYSTEMS INCORPORATED

                                180 Varick Street
                               New York, NY 10014
                                 (212) 645-1405

                          ----------------------------

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS

                         Date:    May 24, 1999
                         Time:    10:00 a.m.

   
                         Place:   New York Hilton & Towers
    

                                  1355 Avenue of the Americas
                                  New York, New York 10019

                          ----------------------------

Items of Business:

1  Election of ten directors.
2. Approval of an amendment to the Company's 1996  Incentive  Stock Option Plan,
   as amended  (the "1996 ISO Plan") to increase  the number of shares of common
   stock which are authorized to be issued under the 1996 ISO Plan.
3. Approval of  amendments  to the 1996  Non-Qualified  Stock  Option  Plan,  as
   amended (the "1996 Non-Qualified  Plan") to (i) increase the number of shares
   of  common  stock  which  are   authorized   to  be  issued  under  the  1996
   Non-Qualified Plan, and (ii) increase the annual option grant made to members
   of the Board of Directors and the Chairman who are not full-time employees of
   the Company under the 1996 Non-Qualified Plan.
4. Approval of an amendment to the Company's  certificate  of  incorporation  to
   increase  the number of shares of common stock the Company is  authorized  to
   issue.
5. Approval  of the  grant of an  option to the  President  and Chief  Executive
   Officer.
6. Approval of the grant of an option to the Executive  Vice President and Chief
   Operating Officer.
7. Ratification  of the  appointment  of KPMG LLP as the  Company's  independent
   certified public accountants for the fiscal year ending December 31, 1999.
8. Any other matters properly brought before the shareholders at the meeting.

Record Date:

      Only  holders of the common  stock of record at the close of  business  on
April 7, 1999 are entitled to notice of and to vote at the meeting.

Annual Report:

      Our  1998  Annual  Report,  which  is not a part of the  proxy  soliciting
material, is enclosed.

Proxy Voting:

      It is important that your shares be represented  and voted at the meeting.
To vote,  please complete,  sign and date the enclosed proxy and promptly return
it in the envelope provided to our transfer agent, EquiServe, 150 Royall Street,
Mail Stop 45-02-62, Canton, MA 02021. Sending in your proxy will not prevent you
from voting in person at the meeting. 

                                             By Order of the Board of Directors

   
                                             /s/ John B. Landes
New York, New York                           JOHN B. LANDES
April 21, 1999                               Secretary
    
                                      (i)
<PAGE>

                                Table of Contents

ABOUT THE MEETING..............................................................1
What is the purpose of the meeting?............................................1
Who is entitled to vote?.......................................................1
Who can attend the meeting?....................................................1
What constitutes a quorum?.....................................................1
How do I vote?.................................................................2
Can I change my vote after I return my proxy card?.............................2
What are the Board's recommendations?..........................................2
What vote is required to approve each item?....................................2
How are votes counted?.........................................................2
Who pays for this proxy solicitation?..........................................2
STOCK OWNERSHIP................................................................3
Who are the largest owners of the Company's stock?.............................3
How much stock do the Company's directors, certain officers 
  and certain others own?......................................................3
ITEM 1--ELECTION OF BOARD OF DIRECTORS.........................................5
Nominees for Director..........................................................5
Business Experience of Nominees for Director...................................6
Directors' Compensation........................................................8
Information Concerning Board and Committee Meetings............................9
Information Concerning Officers...............................................10
Certain Transactions..........................................................11
Executive Compensation........................................................11
Report of the Compensation Committee on Executive Compensation................11
Compensation Committee Interlocks and Insider Participation...................13
Summary Compensation Table....................................................14
Option Grants for Fiscal 1998.................................................16
Option and Warrant Exercises and Values for Fiscal 1998.......................17
Stock Price Performance.......................................................18
ITEM 2 -- Approval of amendment to the 1996 Incentive Stock Option Plan.......19
ITEM 3 -- Approval of amendments to the 1996 Non-Qualified Stock Option 
  Plan........................................................................23
ITEM 4 -- Approval of amendment to the Certificate of Incorporation...........27
ITEM 5 -- Approval of option grant to the President and Chief Executive 
  Officer.....................................................................29

   
ITEM 6 -- Approval of option grant to the Executive Vice President and 
  Chief Operating Officer.....................................................31
ITEM 7 -- Ratification of the appointment of KPMG LLP for fiscal 1999.........33
Stockholder Proposals for fiscal 1999.........................................33
    
   
                                   (i)
<PAGE>

                          IMCLONE SYSTEMS INCORPORATED

                                180 Varick Street

                            New York, New York 10014

                                -----------------

                                 PROXY STATEMENT

                                -----------------
                        
   
      This proxy statement is furnished in connection  with the  solicitation of
proxies  for use at the  Annual  Meeting  of  Stockholders  of  ImClone  Systems
Incorporated  (the  "Company") to be held at 10:00 a.m.,  local time, on Monday,
May 24, 1999, at the New York Hilton & Towers, 1355 Avenue of the Americas,  New
York, New York 10019, and at any adjournments thereof.
    

ABOUT THE MEETING

What is the purpose of the meeting?

At  the  meeting,  stockholders  will  act  upon  the  matters  outlined  in the
accompanying notice of meeting, including the election of directors, approval of
an amendment to the Company's 1996 Incentive  Stock Option Plan, as amended (the
"'96 ISO Plan"),  approval of  amendments to the  Company's  1996  Non-Qualified
Stock Option Plan, as amended (the "1996  Non-Qualified  Plan"),  approval of an
amendment to the Company's  certificate of incorporation,  approval of the grant
of an option to the Company's President and Chief Executive Officer, approval of
the grant of an option  to the  Company's  Executive  Vice  President  and Chief
Operating  Officer and ratification of the Company's  independent  auditors.  In
addition, the Company's management will report on the performance of the Company
during fiscal 1998 and respond to questions from stockholders.

Who is entitled to vote?

Only  stockholders of record at the close of business on the record date,  April
7, 1999, are entitled to receive notice of the meeting and to vote the shares of
common stock that they held on that date at the meeting,  or any postponement or
adjournment of the meeting.  Each outstanding  share entitles its holder to cast
one vote on each matter to be voted upon.

Who can attend the meeting?

Although we  encourage  you to complete and return the proxy card to ensure that
your vote is counted,  you can attend the annual meeting and vote your shares in
person. All stockholders as of the record date, or their duly appointed proxies,
may  attend the  meeting.  Please  note that if you hold your  shares in "street
name"  (that is,  through a broker or other  nominee),  you will need to bring a
copy of a brokerage  statement  reflecting your stock ownership as of the record
date and check in at the registration desk at the meeting.

What constitutes a quorum?

   
The presence at the meeting, in person or by proxy, of the holders of a majority
of the shares of common stock  outstanding on the record date will  constitute a
quorum,  permitting the meeting to conduct its business.  As of the record date,
24,618,255  shares of common  stock of the  Company  were  outstanding.  Proxies
received but marked as abstentions and broker  non-votes will be included in the
calculation of the number of shares considered to be present at the meeting.
    

<PAGE>

   
How do I vote?

If you complete and properly sign the  accompanying  proxy card and return it to
the Company, it will be voted as you direct. If you are a registered stockholder
and attend the  meeting,  you may deliver your  completed  proxy card in person.
"Street name" stockholders who wish to vote at the meeting will need to obtain a
proxy form from the institution that holds their shares.
    

Can I change my vote after I return my proxy card?

Yes. Even after you have submitted  your proxy,  you may change your vote at any
time before the proxy is exercised  by filing with the  Secretary of the Company
either a notice of revocation or a duly executed proxy bearing a later date. The
powers of the proxy  holders  will be  suspended  if you attend  the  meeting in
person and so request,  although  attendance  at the meeting  will not by itself
revoke a previously granted proxy.

What are the Board's recommendations?

The  persons  named as proxy  holders on the proxy card will vote in  accordance
with the  recommendations  of the Board of Directors (the "Board").  The Board's
recommendation  is "for"  each of the items set forth in this  proxy  statement.
With respect to any other  matter that  properly  comes before the meeting,  the
proxy holders will vote as recommended by the Board or, if no  recommendation is
given, in their own discretion.

What vote is required to approve each item?

Election of Directors.  The affirmative vote of a plurality of the votes cast at
the meeting is required for the election of directors.

   
Amendment of Certificate of  Incorporation.  The affirmative vote of the holders
of a majority of the shares  outstanding on the record date will be required for
approval.  A properly  executed proxy marked  "ABSTAIN" with respect to any such
item will not be voted.
    

Other  Items.  For each other  item,  the  affirmative  vote of the holders of a
majority of the shares present in person or represented by proxy and entitled to
vote on the item will be required for approval. A properly executed proxy marked
"ABSTAIN"  with  respect to any such item will not be voted  although it will be
counted  for  purposes  of  determining  the  number of votes  cast on the item.
Accordingly,  an  abstention  will  have  the  effect  of a  negative  vote.  An
abstention will,  however,  be counted for purposes of determining whether there
is a quorum.

How are votes counted?

If you hold your shares in "street name" through a broker or other nominee, your
broker or nominee  will not be permitted to vote your shares on matters that the
New York Stock  Exchange does not  determine to be routine.  Thus, if you do not
give your broker or nominee specific  instructions on non-routine matters,  your
shares may not be voted on those matters and will not be counted in  determining
the number of shares necessary for approval.  Shares represented by such "broker
non-votes" will,  however,  be counted in determining  whether there is a quorum
and in determining  the number of votes cast on a routine item.  Items 1,4 and 7
are considered routine matters.
Items 2, 3, 5 and 6 are considered non-routine matters.

Who pays for this proxy solicitation?

We do. In addition to sending you these  materials,  some of our  employees  may
contact you by telephone,  by mail, or in person.  None of these  employees will
receive any extra  compensation  for doing this.  In addition,  we have retained
Corporate  Investor  Communications,  Inc. to assist us in soliciting your proxy
for a fee of $5,000 plus reasonable out-of-pocket expenses.


                                       2
<PAGE>

                                 STOCK OWNERSHIP

Who are the largest owners of the Company's stock?

   
Except as set forth in the table below, the Company knows of no single person or
group  that is the  beneficial  owner of more  than 5% of the  Company's  common
stock.  Unless otherwise  indicated,  information about 5% beneficial holders is
based  solely on Schedule  13G reports  filed with the  Securities  and Exchange
Commission ("SEC").
    

How much stock do the Company's  directors,  certain officers and certain others
own?

The following table shows the amount of common stock of the Company beneficially
owned  (unless  otherwise  indicated)  by the  Company's  directors,  the  Named
Officers in the Summary Compensation Table below and the directors and executive
officers  of  the  Company  as a  group.  Except  as  otherwise  indicated,  all
information is as of April 1, 1999.  "Beneficial  Ownership" is a technical term
defined by the SEC to mean more than ownership in the usual sense.  For example,
you  "beneficially  own" our common  stock if you own it directly or  indirectly
(through  a  relationship,  a position  as a  director  or trustee or through an
agreement).

                                                      Shares
                                                      Beneficially      Percent
Name and Address(1)                                   Owned             Owned(2)
- -------------------                                   -----             --------

The Group Oracle .................................    1,496,700(3)      5.86%
712 Fifth Avenue, NY, NY 10019

Samuel D. Waksal, Ph.D ...........................    1,300,583(4)      5.12%

Harlan W. Waksal, M.D ............................    1,098,380(5)      4.36%

   
Robert F. Goldhammer .............................      852,390(6)      3.39%

Carl S. Goldfischer, M.D .........................      241,666(7)      *

John B.Landes ....................................      233,500(8)      *

John Mendelsohn, M.D .............................      173,476(9)      *

David M. Kies ....................................      150,500(10)     *

Paul B. Kopperl ..................................       71,460(11)     *

Vincent T. DeVita, Jr., M.D ......................       63,592(12)     *

Jean Carvais, M.D ................................       48,542(13)     *

William R. Miller ................................       29,897(14)     *

Richard Barth ....................................       29,000(15)     *

John A. Gilly, Ph.D ..............................        5,198(16)     *

All Directors and Executive Officers as a group
  (11) persons) ..................................    4,059,486         14.98%

* Less than 1%.

(1)   Unless  otherwise  noted,  each  person's  address  is in care of  ImClone
      Systems Incorporated, 180 Varick Street, Seventh Floor, New York, New York
      10014.
    


                                       3
<PAGE>

(2)   The percentage of voting stock owned by each  stockholder is calculated by
      dividing (i) the number of shares deemed to be  beneficially  held by such
      stockholder  as of April 1, 1999, as  determined  in accordance  with Rule
      13d-3 of the  Securities  Exchange Act of 1934, as amended (the  "Exchange
      Act"), by (ii) the sum of (A) 24,617,358  which is the number of shares of
      common stock outstanding as of April 1, 1999 plus (B) the number of shares
      of common stock  issuable upon exercise of currently  exercisable  options
      and  warrants  held by such  stockholder.  For  purposes of this  security
      ownership table "currently exercisable options" and "currently exercisable
      warrants" consist of options and warrants  exercisable as of April 1, 1999
      or within 60 days after April 1, 1999.  Shares of the  Company's  Series A
      Convertible  Preferred Stock (the "Series A preferred  stock" or "Series A
      preferred shares") are not included in the denominator because they do not
      have voting rights.

(3)   Includes   925,000   shares   issuable  upon  the  exercise  of  currently
      exercisable  warrants.  This  information  is as of April 5,  1999 and was
      obtained from a letter of confirmation  supplied by The Oracle Group.  The
      Oracle Group is comprised of various  investment  partnerships and managed
      accounts controlled by Larry N. Feinberg.

(4)   Includes   350,000   shares   issuable  upon  the  exercise  of  currently
      exercisable  warrants  and 415,000  shares  issuable  upon the exercise of
      currently exercisable options.

(5)   Includes   240,000   shares   issuable  upon  the  exercise  of  currently
      exercisable  options;   340,680  shares  issuable  upon  the  exercise  of
      currently  exercisable  warrants;  and 2,600 shares owned by Dr.  Waksal's
      sons as to which he disclaims beneficial ownership.

(6)   Includes   113,542   shares   issuable  upon  the  exercise  of  currently
      exercisable  options;   379,990  shares  issuable  upon  the  exercise  of
      currently  exercisable  warrants;  and 13,314  shares  held in trust as to
      which Mr. Goldhammer disclaims beneficial ownership.

(7)   Consists of 241,666 shares issuable upon exercise of currently exercisable
      options.

(8)   Includes 94,000 shares issuable upon the exercise of currently exercisable
      options  and  104,000  shares  issuable  upon the  exercise  of  currently
      exercisable warrants.

(9)   Consists  of  173,476  shares  issuable  upon the  exercise  of  currently
      exercisable options.

(10)  Includes 12,500 shares issuable upon the exercise of currently exercisable
      options and 8,000 shares held by Mr. Kies as  custodian  for his son as to
      which he disclaims beneficial ownership.

(11)  Includes 42,500 shares issuable upon the exercise of currently exercisable
      options;  and 500  shares  held by Mr.  Kopperl's  spouse  as to which Mr.
      Kopperl disclaims beneficial ownership.

(12)  Includes 63,292 shares issuable upon the exercise of currently exercisable
      options.

(13)  Consists  of  48,542  shares  issuable  upon  the  exercise  of  currently
      exercisable options.

(14)  Includes 28,897 shares issuable upon the exercise of currently exercisable
      options.

(15)  Includes  27,500 shares  issuable  upon exercise of currently  exercisable
      options.

(16)  Consists of shares of common  stock,  191 of which are held in a custodial
      account for the benefit of Dr. Gilly's sons.  Dr. Gilly ceased  employment
      with the  Company as of December  31,  1998 and all his options  remaining
      unexercised on that date were cancelled.

(17)  Includes an aggregate of (i) 2,477,585  shares  issuable upon the exercise
      of currently exercisable options and warrants and (ii) 24,414 shares as to
      which beneficial  ownership is disclaimed.  Shares held by Mr. Landes have
      not been  included as he is not  considered  an  executive  officer of the
      Company  and  shares  held by Mr.  Gilly have not been  included  as he no
      longer is employed by the Company.


                                       4
<PAGE>

                                 PROPOSAL NO. 1

                         ELECTION OF BOARD OF DIRECTORS

      An entire board of directors,  consisting of ten members,  will be elected
at the meeting.  The directors  elected will hold office until their  successors
are elected, which should occur at the next annual meeting.

Nominations.  At the meeting,  the Board of Directors  will nominate the persons
named in this proxy statement as directors. Although we don't know of any reason
why any of these  nominees  might not be able to serve,  the board of  directors
will propose a substitute nominee if any nominee is not available for election.

   
General  Information  About the  Nominees.  All of the  nominees  are  currently
directors  of the  Company.  Each of the  nominees has agreed to be named in the
proxy statement and to serve as a director if elected.
    
       

Nominees For Director
                                    Current Position               Director of 
Name                                with Company                   Company Since
- ----                                ------------                   -------------
Richard Barth (1)(2)                Director                       1996
Jean Carvais, M.D.                  Director                       1993
Vincent T. DeVita, Jr., M.D. (1)(5) Director                       1992
Robert F. Goldhammer (2)(3)(4)      Chairman of the Board          1984
David M. Kies (2)(4)                Director                       1996
Paul B. Kopperl (1)(2)(4)           Director                       1993

   
John Mendelsohn, M.D. (4)(5)        Director                       1998
    

William R. Miller (1)(4)            Director                       1996

   
Harlan W. Waksal, M.D. (3)(4)(5)    Executive  Vice   President,   1984
                                    Chief Operating Officer and 
                                    Director
    

Samuel D. Waksal, Ph.D. (3)(5)      President,  Chief Executive    1985
                                    Officer and Director

(1) Member of Audit Committee
(2) Member of Compensation and Stock Option Committee
(3) Member of Executive Committee
(4) Member of Nominating and Corporate Governance Committee
(5) Member of Research Oversight Committee


                                       5
<PAGE>

                  BUSINESS EXPERIENCE OF NOMINEES FOR DIRECTOR

      Richard Barth,  67, has been a Director of the Company since October 1996.
Mr.  Barth  served as Chairman of the Board of  Ciba-Geigy  Corporation,  United
States ("Ciba-Geigy") from 1990 until December 1996, and was President and Chief
Executive  Officer of  Ciba-Geigy  from 1986 until  April 1996.  Mr.  Barth is a
member of the Board of Directors of numerous  organizations,  including Novartis
Corporation,  United States, The Bank of New York and Bowater,  Inc., and serves
as Chairman of the Board of Trustees of New York Medical College.

      Jean  Carvais,  M.D.,  72, has been a Director of the  Company  since July
1993,  and has since 1984 been an  independent  consultant  to  companies in the
pharmaceutical  industry.  Prior to that time,  Dr. Carvais was President of The
Research Institute of Roger Bellon, S.A., now a division of Rhone-Poulenc Rorer,
Inc. ("Rhone-Poulenc"). As such, he was involved in the development of a line of
anti-cancer drugs, including Bleomycin and Adriamycin,  as well as a new line of
antibiotics and quinolones.  Following the acquisition of Roger Bellon,  S.A. by
Rhone-Poulenc,  Dr. Carvais became a member of Rhone-Poulenc's  central research
committee  which  directs  the  company's  worldwide  research  and  development
activities. Dr. Carvais is a director of Columbia Laboratories, Inc.

      Vincent T. DeVita, Jr., M.D., 64, has been a Director of the Company since
February  1992.  Dr.  DeVita is Director  of the Yale  Cancer  Center as well as
Professor of Medicine and  Professor of  Epidemiology  and Public Health at Yale
University  School of Medicine,  New Haven,  Connecticut.  From  September  1988
through  June  1995,  Dr.  DeVita  served as  Attending  Physician  at  Memorial
Sloan-Kettering  Cancer Center  ("Sloan-Kettering"),  New York, and through June
1991 as  Physician-in-Chief.  From 1980 to 1988,  he served  under  Presidential
appointment as Director of the National Cancer Institute  ("NCI"),  where he had
held various positions since 1966. During his years with the NCI, Dr. DeVita was
instrumental in developing the first successful  combination cancer chemotherapy
program. This work ultimately led to effective regimens of curative chemotherapy
for a variety of cancers.  Dr. DeVita's  numerous awards include the 1990 Armand
Hammer Cancer Prize and the 1982 Albert and Mary Lasker  Medical  Research Award
for his contribution to the cure of Hodgkin's  disease.  Dr. DeVita received his
M.D. from the George Washington University School of Medicine,  Washington,  DC,
in 1961.

   
      Robert F.  Goldhammer,  68, has served as the  Company's  Chairman  of the
Board since  February  1991 and has been a Director of the Company since October
1984.  Mr.  Goldhammer  has been a partner of Concord  International  Investment
Group,  L.P.  since 1991.  He was a partner of Rohammer  Corporation,  a private
investment  company,  from 1989 to 1991.  He was a managing  director of Kidder,
Peabody Group Inc., an investment  banking firm,  from May 1988 to January 1989.
He is a director of Esterline Technologies Corporation.
    

      David M. Kies, 55, has been a Director of the Company since June 1996. Mr.
Kies  is a  Partner  of the  New  York  based  law  firm  Sullivan  &  Cromwell,
specializing  in mergers and  acquisitions,  securities  and  general  corporate
matters.  Mr. Kies joined Sullivan & Cromwell in 1968, and was elected a partner
of the firm in 1976.  From 1991 until 1995,  he was the managing  partner of the
firm's London office.

      Paul B. Kopperl,  65, has served on the Board since  December  1993. He is
President of Pegasus Investments,  Inc., Boston, a private investment management
firm established in 1994. He has served as President of Delano & Kopperl,  Inc.,
a financial  advisory firm in Boston and its predecessor  firms from 1976 to the
present. From 1967 through 1975 he was Vice President and a principal of Kidder,
Peabody & Co.  Incorporated,  New York, an investment banking firm. From 1959 to
1967 he was an associate  with Goldman,  Sachs & Co., New York. Mr. Kopperl is a
Trustee and Governor of the Dana-Farber  Cancer Institute,  Boston, and over the
years  has  served  as  a  trustee  or  director   of  numerous   not-for-profit
educational, performing arts and social welfare organizations and businesses.

      John  Mendelsohn,  M.D.,  62, has been a  Director  of the  Company  since
February  1998. He has served as the President of M.D.  Anderson  Cancer Center,
University of Texas,  where he has also been  Professor of Medicine  since 1996.
From  1985  to  1996  he  was  Chairman  of  the   Department   of  Medicine  at
Sloan-Kettering,  New York, as well as holder of the Winthrop  Rockefeller Chair
in Medical Oncology at Sloan-Kettering.  He was also Professor and Vice-Chairman
of Medicine at Cornell University Medical College and an attending  physician at
both Memorial and New York Hospitals.  Dr.  Mendelsohn  served on the faculty of
the University of California,  San Diego and was instrumental in the creation of
the University's  Cancer Center,  where he served as Director from 1976 to 1985.
Dr. Mendelsohn's work has focused on growth factors and their role in regulating
the proliferation of cancer cells through cell surface receptors. Dr. Mendelsohn
was  responsible  for  developing  specific  monoclonal  antibodies  that 


                                       6
<PAGE>

block  receptors,  including  epidermal growth factor  receptors,  which mediate
growth  factor  activation of cell and growth and  division.  Dr.  Mendelsohn is
currently a board  member of the Richard  Lounsbery  Foundation  and the Greater
Houston Partnership,  and a fellow of the New York Academy of Medicine. In 1997,
Dr.  Mendelsohn was elected to the Institute of Medicine of the National Academy
of Sciences.

      William R. Miller, 70, has been a Director of the Company since June 1996.
Mr.   Miller  served  as  Vice  Chairman  of  the  Board  of  Directors  of  the
Bristol-Myers Squibb Company from 1985 until 1991, at which time he retired. Mr.
Miller is a director of Isis  Pharmaceuticals,  Inc.,  Transkaryotic  Therapies,
Inc., Westvaco  Corporation and Xomed Surgical Products,  Inc. He is Chairman of
the Board of Vion  Pharmaceuticals,  Inc.  and SIBIA  Neurosciences,  Inc. He is
Chairman of the Board of Trustees of the Cold Spring Harbor  Laboratory and is a
past Chairman of the Board of the Pharmaceutical  Manufacturers Association. Mr.
Miller is a  Trustee  of the  Manhattan  School  of  Music,  Metropolitan  Opera
Association and Opera Orchestra of New York. He is a member of Oxford University
Chancellor's  Court of  Benefactors,  Honorary  Fellow  of St.  Edmund  Hall and
Chairman of the English-Speaking Union of the United States.

      Harlan W.  Waksal,  M.D.,  46, is a founder of the  Company and has been a
Director  since  April  1984.  He  has  directed  the  Company's   research  and
development  since April 1985,  and has served as the Company's  Executive  Vice
President and Chief Operating Officer since March 1987. From 1985 to March 1987,
Dr. Waksal served as the Company's  President.  Dr. Waksal received his training
in Internal  Medicine from  Tufts-New  England  Medical  Center  Hospital and in
Pathology  from Kings County  Hospital in Brooklyn,  New York from 1982 to 1987.
From 1984 to 1985,  Dr.  Waksal was Chief  Resident in Pathology at Kings County
Hospital.  He  received  his  Medical  Degree  from Tufts  University  School of
Medicine in 1979. He is currently Adjunct Assistant  Professor in the Department
of Pathology at Downstate  Medical  Center,  New York. Dr. Harlan Waksal and Dr.
Samuel Waksal are brothers.

      Samuel D. Waksal, Ph.D., 51, President of the Company, is a founder of the
Company and has been its Chief  Executive  Officer and a Director  since  August
1985 and President  since March 1987. From 1982 to 1985, Dr. Waksal was a member
of the  faculty of Mt.  Sinai  School of  Medicine  as  Associate  Professor  of
Pathology and Director of the Division of Immunotherapy within the Department of
Pathology.  He has  served  as  visiting  Investigator  of the  National  Cancer
Institute,  Immunology Branch, Research Associate of the Department of Genetics,
Stanford  University Medical School,  Assistant  Professor of Pathology at Tufts
University School of Medicine and Senior Scientist for the Tufts Cancer Research
Center. Dr. Waksal was a scholar of the Leukemia Society of America from 1979 to
1984.  Dr. Waksal  currently  serves on the Executive  Committee of the New York
Biotechnology  Association,  the  Board of  Directors  of  Cadus  Pharmaceutical
Corporation  and is Chairman of the New York  Council  for the  Humanities.  Dr.
Samuel Waksal and Dr. Harlan Waksal are brothers.

   
      The  Board  recommends  a vote  "FOR"  each of the  nominees  named  above
(Proposal No. 1 on your proxy card).
    


                                       7
<PAGE>

                             DIRECTORS' COMPENSATION
                                Cash Compensation

   
      Each  director of the Company,  exclusive of the  Chairman,  who is not an
employee of the Company or who does not otherwise provide consulting services to
the Company  receives  compensation  of $10,000 per year,  or a pro rata portion
thereof for persons not serving the full fiscal year, for such person's services
as  a  director  as  well  as   reimbursement   of  the  director's   reasonable
out-of-pocket expenses incurred in connection with his Board and Board committee
activities.  The  Chairman,  who is not an  employee  of the  Company,  receives
$150,000 per year for his services as Chairman as well as  reimbursement  of his
reasonable  out of pocket  expenses  incurred in  connection  with his Board and
Board committee activities.  In addition,  subject to the first sentence of this
paragraph,  the Chairman of each of the Audit Committee,  Compensation and Stock
Option  Committee and Nominating  and Corporate  Governance  Committee  receives
$5,000 per year as compensation for the services of each as Chairman.
    

Directors' Stock Options

   
      Pursuant to the Company's 1996 Non-Qualified  Plan,  directors who are not
full-time employees of the Company  automatically  receive on each February 15th
an option to  purchase  2,500  shares of  common  stock,  or a pro rata  portion
thereof for persons not having  served the full fiscal  year.  Such options vest
after one full year of  service  on the Board from the date of grant and have an
exercise price equal to the fair market value of the common stock on the date of
grant.  Directors newly joining the Board who are not full-time employees of the
Company are made a one-time  option grant under the 1996  Non-Qualified  Plan to
purchase  25,000  shares of common  stock.  Such  options  vest as to 25% of the
shares of common stock over the  four-year  period  commencing  with the date of
grant,  subject  to such  individual's  continued  service  on the  Board on the
scheduled  date of vesting,  and have an exercise price equal to the fair market
value of the common stock on the date of grant. From time to time,  non-employee
directors are granted additional options in consideration for providing services
on the Board. No such additional options were granted in 1998.  Shareholders are
being asked to approve an amendment to the 1996  Non-Qualified  Plan to increase
the  automatic  annual  grant to  directors  (except the  Chairman)  who are not
full-time  employees  of the Company  from 2,500 to 15,000 and to  increase  the
automatic  annual  grant to the Chairman  who is not a full-time  employee  from
2,500 to 30,000 (Proposal No. 3 to this proxy statement).
    

      The table below sets forth option grants to non-employee  directors during
the year ended December 31, 1998 in consideration  for such directors serving on
the Board:

           Name                                       Number of Options
           ----                                       -----------------
     Richard Barth                                         2,500(1)
     Jean Carvais                                          2,500(1)
     Vincent T. DeVita, Jr.                                2,500(1)
     Robert F. Goldhammer                                  2,500(1)
     David M. Kies                                         2,500(1)
     Paul B. Kopperl                                       2,500(1)
     John Mendelsohn                                       2,226(1)
                                                          25,000(2)
     William R. Miller                                     2,500(1)


(1) These options were granted  automatically  pursuant to the terms of the 1996
Non-Qualified  Plan on February 15, 1998 at a per share  exercise price of $6.94
which  is  equal to the fair  market  value of the  common  stock on the date of
grant. They vested and became exercisable in their entirety on February 15, 1999
and terminate February 14, 2008. Pursuant to the terms of the 1996 Non-Qualified
Plan, Dr. Mendelsohn received a smaller grant due to his joining the Board after
the beginning of the 1998 fiscal year.

(2) This  option was  granted  automatically  pursuant  to the terms of the 1996
Non-Qualified  Plan upon Dr.  Mendelsohn's  newly  joining  the Board in January
1998. It is exercisable at a per share exercise price of $5.97,  the fair market
value  of the  common  stock on the date of  grant,  and  vests as to 25% of the
shares of common  stock on each of January 30, 1999,  January 30, 2000,  January
30, 2001 and January 30, 2002, subject to Dr. Mendelsohn's  continued service on
the Board.


                                       8
<PAGE>

                   INFORMATION CONCERNING BOARD AND COMMITTEE
                      MEETINGS AND COMMITTEES OF THE BOARD

      The Board of  Directors  oversees  the business and affairs of the Company
and monitors  the  performance  of  management.  In  accordance  with  corporate
governance  principles,   the  Board  does  not  involve  itself  in  day-to-day
operations. During the year ended December 31, 1998, there were five meetings of
the Company's Board. No incumbent  director attended fewer than 75% of the total
number of meetings of the Board and of the  Committees  of the Board on which he
served.

      The Company has an Executive Committee of the Board composed of Dr. Samuel
D.  Waksal  (Chairman),  Robert F.  Goldhammer  and Dr.  Harlan W.  Waksal.  The
Executive  Committee  acts for the Board when  formal  Board  action is required
between Board  meetings.  The Executive  Committee has all the power of the full
Board in the management of the business and affairs of the Company, except those
powers that by law cannot be delegated by the Board. The Executive Committee met
two times during the year ended  December 31, 1998 and also took during the year
certain other action by means of unanimous written consent.

      The  Company  has an Audit  Committee  of the  Board  composed  of Paul B.
Kopperl (Chairman), Vincent T. DeVita, Jr., Richard Barth and William R. Miller.
The Audit Committee  considers matters relating to the adequacy of the Company's
internal  financial  controls and the  objectivity  of the  Company's  financial
reporting, reviews the Company's annual financial statements and the performance
of the Company's auditors and makes recommendations to the Board with respect to
these  matters.  The Audit  Committee  also  reviews the  Company's  "Year 2000"
compliance  program.  The  Audit  Committee's  Chairman  reviews  the  Company's
quarterly  financial  statements.  The Audit Committee met twice during the year
ended December 31, 1998.

      The  Company  has  a   Compensation   and  Stock  Option   Committee  (the
"Compensation  Committee")  of  the  Board  composed  of  Robert  F.  Goldhammer
(Chairman),  Paul B. Kopperl,  David M. Kies and Richard Barth. The Compensation
Committee is responsible for developing  executive  compensation  policies.  The
Compensation  Committee (i)  determines on an annual basis the base salary to be
paid to the Chief Executive Officer and determines  bonuses and incentive awards
to be paid from time to time to the Chief Executive  Officer;  and (ii) approves
on an annual basis a salary plan for other senior officers on the recommendation
of the Chief Executive  Officer in conjunction  with other senior  personnel and
approves  bonuses  and  incentive  awards  to be paid  from time to time to such
senior  officers  on  the  recommendation  of the  Chief  Executive  Officer  in
conjunction  with  other  senior  personnel.  The  Compensation  Committee  also
administers the Company's various stock option and purchase plans, including the
granting of options under the option plans. The  Compensation  Committee met one
time  during  the year ended  December  31,  1998 and also took  during the year
certain other action by means of unanimous written consent.

      The Company has a Nominating and Corporate  Governance  Committee composed
of David M. Kies  (Chairman),  Paul B.  Kopperl,  John  Mendelsohn,  William  R.
Miller,  Robert F. Goldhammer and Harlan W. Waksal. The Nominating and Corporate
Governance Committee considers and makes  recommendations to the Board regarding
Board and committee  nominees and membership,  director  performance and officer
candidates. The Nominating and Corporate Governance Committee also considers and
makes recommendations to the Board with respect to corporate  organizational and
governance matters.  The Corporate  Governance Committee did not meet during the
year ended  December  31,  1998 but took  certain  action by means of  unanimous
written consent.  The Nominating and Corporate  Governance  Committee  considers
nominations  for director made by stockholders of the Company in accordance with
the  procedures  for  submission  of proposals at annual or special  meetings of
stockholders set forth in the Company's Amended and Restated By-laws.

      The  Company  has a Research  Oversight  Committee  composed  of Samuel D.
Waksal (Chairman), Vincent T. DeVita, Jr., John Mendelsohn and Harlan W. Waksal.
The Research Oversight Committee is responsible for directing the research focus
of the Company.  The Research  Oversight  Committee did not meet during the year
ended December 31, 1998.


                                       9
<PAGE>

                         INFORMATION CONCERNING OFFICERS

      Certain  information  concerning  each  officer of the Company is provided
below.

      Samuel D. Waksal,  Ph.D., is the President and Chief Executive  Officer of
the Company. Certain information concerning Dr. Waksal appears on page seven.

      Harlan  W.  Waksal,  M.D.,  is the  Executive  Vice  President  and  Chief
Operating  Officer of the Company.  Certain  information  concerning  Dr. Waksal
appears on page seven.

      Peter Bohlen, Ph.D., 56, has been Vice President,  Research of the Company
since  September 1996. From November 1995 to July 1996 he was Senior Director of
Ixsys, a privately-held biotechnology company. From October 1987 to June 1996 he
was  department  head of the Molecular  Biology  Section of American  Cyanamid's
Medical Research Division and director of the company's angiogenesis program. He
also has held  academic  positions  at the Salk  Institute,  San  Diego  and the
University of Zurich,  Switzerland.  Dr. Bohlen  received his Ph.D. in chemistry
from the  University of Berne in  Switzerland.  In 1983, he received the Cloetta
Award in Switzerland for his contributions in the field of protein analysis.

      Michael Feldman, Ph.D., 73, became Vice President,  Discovery Research for
the Company in May 1995.  Prior thereto he served as Director of Basic  Research
for the Company since 1993. Dr. Feldman is former head of the Department of Cell
Biology at the Weizmann  Institute of Science in Rehovot,  Israel,  and a former
dean of its  graduate  school.  He has  done  pioneering  work in the  areas  of
transplantation   immunology,   differentiation   of   lymphocytes   and  cancer
immunology.  In 1984,  he received the Griffuel  Award in France for his work in
cancer  metastasis,  and in 1986 received the  Rothschild  Award for his work in
immunology.  Dr.  Feldman is a member of the  Israeli  Academy of  Sciences  and
Humanities and the World Academy of Arts and Sciences.

      Carl S. Goldfischer,  M.D., 40, has served as Vice President,  Finance and
Chief  Financial  Officer  since May 1996.  From June  1994  until  joining  the
Company,  Dr. Goldfischer served as a healthcare analyst with Reliance Insurance
Company.  From June 1991  until June  1994,  Dr.  Goldfischer  was  Director  of
Research  for D.  Blech & Co.,  an  investment  banking  firm.  Dr.  Goldfischer
received a doctorate  of medicine  from Albert  Einstein  College of Medicine in
1988 and served as a resident in radiation  oncology at  Montefiore  Hospital of
the Albert  Einstein  College of  Medicine  until  1991.  Dr.  Goldfischer  is a
director of Immulogic Pharmaceutical  Corporation.  Dr. Goldfischer has resigned
from the Company to resume his career in investment banking. This resignation is
expected to be effective the end of May 1999.

      John B. Landes, 51, has served as Vice President, Business Development and
General  Counsel since November  1992.  Prior  thereto,  he was Vice  President,
Administration  and Legal since December 1984. He also has been Secretary of the
Company  since April 1985 and served as its  Treasurer  from April 1984  through
September  1991,  except for an interim  period from  December  1988 to February
1991.  From 1978 to 1984,  Mr. Landes was an associate  attorney with the Boston
law firm of Mahoney, Hawkes and Goldings.

      Ronald A.  Martell,  37,  has  served  as the  Company's  Vice  President,
Marketing  since  November  1998.  Prior to  joining  the  Company  he worked at
Genentech,  Inc. for ten years where he held various  positions.  Most recently,
from 1996 until joining the Company,  he served as Genentech's  Group Manager of
Oncology  Products  where he  directed  the  launch  of  Herceptin,  Genentech's
monoclonal  antibody product approved to treat breast cancer.  From 1995 to 1996
he served as Senior  Product  Manager  where he  launched  Pulmozyme  for cystic
fibrosis in Europe.  From 1994 through 1995 he served as Manager of  Genentech's
Piedmont Sales Division. Prior to that, he served from 1993 as Associate Product
Manager for Genentech's Pulmozyme.

      S.  Joseph  Tarnowski,  Ph.D.,  45,  has  served  as  the  Company's  Vice
President,  Product and Process Development since January 1999. Prior to joining
the Company, he held various positions with CellPro Inc., the principal business
of which was the  development,  manufacture  and marketing of automated  systems
that utilize monoclonal  antibodies to purify large quantities of specific cells
for therapeutic and diagnostic  applications.  He joined CellPro in June 1992 as
Vice President of Operations and was appointed to the position of Vice President
of Research and  Development  in June 1995 and became Senior Vice  President and
Chief  Technical  Officer in December 1996.  From November 1986 to May 1992, Dr.
Tarnowski  was  Director,  Process  and Product  Development  of Scios Nova Inc.
(formerly  California  Biotechnology  Inc.), a company that develops recombinant


                                       10
<PAGE>

human  proteins  for  therapeutic  uses.  Dr.  Tarnowski  received  a  Ph.D.  in
Biochemistry  from the  University  of Tennessee in 1979 and was a  Postdoctoral
Fellow at the Roche Institute of Molecular Biology from 1979 through 1981.

Section 16(a) Beneficial Ownership Reporting Compliance

   
      Ownership of and  transactions  in the  Company's  securities by executive
officers and directors of the Company and owners of 10% or more of the Company's
outstanding  common  stock are  required to be  reported to the SEC  pursuant to
Section  16(a) of the  Exchange  Act.  During the year ended  December 31, 1998,
based on  information  received by the Company,  one form was untimely filed for
each of Dr. Samuel Waksal,  Dr. Harlan Waksal,  Dr. Carl S.  Goldfischer and Mr.
Robert F. Goldhammer.
    

                              CERTAIN TRANSACTIONS

      During the year ended  December 31, 1998,  the Company paid Dr. Vincent T.
DeVita,  Jr., a director  of the  Company,  a total of $100,000  for  scientific
consulting services provided to the Company by Dr. DeVita.

      In  January  1998,  the  Company   accepted  a  promissory  note  totaling
approximately  $131,000  from  its  President  and CEO in  connection  with  the
exercise of a warrant to purchase  87,305 shares of the Company's  common stock.
The note is due no later  than two years  from  issuance  and is full  recourse.
Interest is payable on the first  anniversary date of the promissory note and on
the stated maturity or any  accelerated  maturity at the annual rate of 8.5%. At
December 31, 1998,  the total amount due the Company,  including  interest,  was
approximately  $142,000 and is classified in the stockholders' equity section of
the balance sheet as a note receivable from officer and stockholder.

   
      In October  1998,  the  Company  accepted  an  unsecured  promissory  note
totaling  $100,000  from its  Executive  Vice  President  and COO.  The note was
payable on demand including  interest at the annual rate of 8.25% for the period
that the loan was  outstanding.  On April 8, 1999, Dr. Waksal repaid the note in
full, including all interest accrued thereon.
    

      In January  1999,  the  Company  accepted  an  unsecured  promissory  note
totaling $60,000 from its Vice President,  Product and Process Development.  The
note is  payable  upon the  earlier  of on  demand  or July 28,  1999 and  bears
interest at an annual rate equal to the prime rate at Citibank, N.A. plus 1% for
the  period  that the  loan is  outstanding.  The  loan was made as a bridge  in
connection with the officer's relocation in connection with accepting employment
with the Company.

                             EXECUTIVE COMPENSATION

Report of Compensation Committee

      The  Compensation  Committee  is  responsible  for  developing  and making
recommendations   to  the  Board  with  respect  to  the   Company's   executive
compensation  policies.  Pursuant  to  authority  delegated  by the  Board,  the
Committee  determines  the  executive  compensation  policy of the  Company  and
determines on an annual basis the compensation to be paid to the Chief Executive
Officer and  approves  compensation  to other  officers of the  Company,  at the
recommendation of the Chief Executive Officer and other supervising personnel.

Overall Philosophy

      The Company's  overall executive  compensation  philosophy is based on the
premise that  compensation  should be set at levels that  support the  Company's
business  strategies and long-term  objectives and should reward  executives for
their contributions to the enhancement of shareholder value. The key elements of
the executive  compensation package are base salary, annual incentive awards and
stock options. In establishing base salaries, annual incentive awards and awards
of stock options,  the Compensation  Committee  considers periodic  compensation
surveys,    including   those   provided   by   third   parties   covering   the
biopharmaceutical industry.  Officers' compensation is compared to that of other
executives in peer group surveys.


                                       11
<PAGE>

      In evaluating each senior executive's  performance,  the Company generally
conforms to the following process:

      o     Company and individual goals and objectives are set at the beginning
            of the performance cycle.

      o     At the end of the performance cycle, the executive's  manager, or in
            the case of the Chief Executive Officer, the Compensation Committee,
            evaluates the accomplishment of the executive's goals and objectives
            and his or her contributions to the Company.

      o     The  executive's  performance  is then  reviewed by the  executive's
            manager with the executive and  consideration  is given to goals for
            the following performance cycle.

      o     The  comparative  results,  combined with  comparative  compensation
            practices  of other  companies  in the  industry,  are then  used to
            determine salary, bonus, and stock option levels.

      The   Compensation   Committee  uses  no  set  formulas  in  making  these
determinations  and may afford  different  weight to different  factors for each
senior  executive.  Such  weighting may vary from year to year.  In  determining
compensation,   the  Compensation   Committee  does  not  attempt  to  correlate
compensation with specific financial results,  such as revenues or profits,  for
the  current  period.   This  is  in  large  part  due  to  the  nature  of  the
biopharmaceutical   industry  in  which  traditional  evaluations  of  corporate
performance  may not apply in  reviewing  the  performance  of  executives.  The
Committee  looks toward the progress of the Company's  research and  development
programs,  its ability to gain  appropriate  levels of support for its  programs
through its strategic partnering  agreements,  its ability to attract,  motivate
and retain talented  employees and its ability to secure capital  sufficient for
its   product   development    programs   to   achieve   rapid   and   effective
commercialization as may be practicable.

Base Salary

      At  the  end  of  each  year,  the  Compensation   Committee  reviews  and
establishes the base salary of the Chief Executive Officer based on a comparison
to national surveys,  taking into  consideration  the Company's  performance and
current  circumstances,  accomplishment  of his  goals  and  objectives  and his
contributions  to the  Company.  The  Compensation  Committee  also  reviews and
approves, or modifies, a salary plan for the other senior executives prepared by
the Chief Executive Officer in conjunction with other senior personnel.

Annual Incentive Awards

      Although the Company does not have a formal bonus plan for its management,
the  Compensation   Committee  determines  annual  incentive  awards  to  senior
executives  from  time to time  based  on  individual  performance  and  Company
performance.  Specific  performance goals of each executive are determined early
each  year  in  direct  consultation  with  the  executive's  supervisor.  These
performance  goals  include  successful  and cost  efficient  management  of the
executive's department and specific contributions made by that department to the
immediate and ultimate goals of the Company.  For the Chief  Executive  Officer,
such goals are determined in reference to the CEO's plan for the coming year for
the  Company as a whole,  as  presented  to the Board.  The  awarding  of annual
incentive  awards  takes  into  consideration  individual  efforts  as  well  as
performance of the Company as a whole. In evaluating  performance of the Company
as a whole, several factors are examined, including productivity of research and
development  programs,  successful movement of development stage products toward
commercialization,  fostering development of successful corporate  partnerships,
expense  control,  financing  efforts and  progress  of the  Company  toward its
short-term and long-term goals.

Long-Term Incentive Compensation

      Stock options and warrants are considered as long-term  incentives and are
intended to link the interests of the executive  with those of the  stockholder.
Such  securities  will  provide  value  to the  grantee  when  the  price of the
Company's stock increases.

         The Compensation  Committee  conducts a formal review from time to time
of the stock option and warrant  holdings and vesting  schedule of each officer.
The Compensation  Committee  authorizes stock option grants (and, in


                                       12
<PAGE>

some cases,  grants of warrants) to the  executives  with  consideration  to the
growth and performance of the Company,  individual performance and contribution,
total stock option and warrant and vesting levels and length of service.

      For their performance in the year ended December 31, 1998, the CEO and the
other Named Officers (as hereinafter  defined) were awarded no warrants and were
awarded options to purchase an aggregate of 945,000 shares of common stock.  See
"Option Grants for Fiscal 1998."

Deductibility of Compensation

      The  Compensation  Committee has reviewed the impact of Section  162(m) of
the Internal Revenue Code of 1986, as amended (the "Code"),  which, beginning in
1994, limits the deductibility of certain otherwise  deductible  compensation in
excess of $1 million  paid to the Chief  Executive  Officer  and the other Named
Officers (as hereinafter defined). It is the policy of the Company to attempt to
have its executive  compensation  plans treated as tax  deductible  compensation
whenever,  in the  judgment  of the  Compensation  Committee,  to do so would be
consistent with the objectives of that compensation plan.

Chief Executive Officer Compensation

      The key elements of the compensation  for the Chief Executive  Officer are
base  salary,  annual  incentive  awards  and  stock  options  or  warrants.  In
evaluating Dr. Samuel Waksal's 1998  performance and in determining Dr. Waksal's
1998  compensation,  the  Compensation  Committee,  along  with the full  Board,
considered the performance of the Company in 1998. In 1998, the Company advanced
its cancer vaccine product,  BEC2, into a Phase III clinical trial, which is the
Company's  first  Phase III trial and one of the first  Phase III trials for any
cancer  vaccine.  C225,  the  Company's  lead product  under  development,  also
continued to advance with the Company  obtaining FDA approval in January 1999 to
commence a Phase III trial for C225 in head and neck  cancers.  The financing of
C225 through  development  was also further  strengthened  with the closing of a
license and  development  agreement  with Merck KGaA where the  Company  further
succeeded in retaining North American rights.  Also considered was the continued
strength  of the  Company's  research  pipeline,  particularly  with  respect to
anti-angiogenesis,   a  core  area  of  the  Company's  research,   as  well  as
pro-angiogenesis.

                                        Compensation and Stock Option Committee

                                        Robert F. Goldhammer, Chairman
                                        Richard Barth
                                        David M. Kies
                                        Paul B. Kopperl

Compensation Committee Interlocks and Insider Participation

      As of December 31, 1998,  the members of the  Compensation  Committee were
Richard  Barth,  Robert  F.  Goldhammer  (Chairman),  David M.  Kies and Paul B.
Kopperl, none of whom is an employee of the Company.


                                       13
<PAGE>

                           SUMMARY COMPENSATION TABLE

      The  Summary   Compensation   Table  sets  forth  the  cash  and  non-cash
compensation  awarded to,  earned by, or paid to the Company's  Chief  Executive
Officer  and the four most  highly  compensated  officers  (other than the Chief
Executive Officer) for the years ended December 31, 1998, 1997 and 1996 who were
serving as  officers  at  December  31,  1998 and whose  total  salary and bonus
exceeded $100,000 for the year ended December 31, 1998 (the "Named Officers").

                                                                               
<TABLE>
<CAPTION>
                                                                               Long Term
                                Annual Compensation                            Compensation Awards
                                -------------------------------------------    -------------------
                                                                Other Annual   Securities Underlying     All Other
                                        Salary      Bonus       Compensation   Options and Warrants      Compensation           
                                Year    ($)(1)     ($)(2)          ($)(3)            (#)(4)                  ($) 
                                ----    ------      -----       ------------   ----------------------    ------------ 
<S>                                     <C>         <C>              <C>            <C>                     <C>         
   
Samuel D. Waksal ............   1998   $300,000    $400,000          --             300,000               $ 10,435(7)
President and Chief             1997    225,000     280,000(5)       --             250,000(6) 10,435       10,435(7)
Executive Officer               1996    225,000     200,000(5)       --              45,000                 10,435(7)

Harlan W. Waksal ............   1998    250,000     300,000          --             250,000                     --          
Executive Vice                  1997    195,000     250,000(8)       --             497,000(6)(9)               --       
President and Chief             1996    195,000     200,000(8)       --              40,000                       
Operating Officer                                                                                       
    
                                                                                                                  
John B. Landes ..............   1998    165,000     120,000          --             135,000                     --       
Vice President,                 1997    165,000      90,000          --              25,000                     --       
Business Development            1996    165,000      50,000          --              30,000                     --       
and General Counsel                                                                                               
                                                                                                                  
Carl S. Goldfischer(10) .....   1998    175,000      75,000          --             125,000                     --       
Vice President, Finance         1997    175,000      90,000          --              25,000(6)                  --       
and Chief Financial             1996    109,000      75,000          --             225,000                     --       
Officer                                                                                                           
                                                                                                                  
   
John A. Gilly(11) ............  1998    175,000        --            --             135,000(12)                 --       
Vice President,                 1997    165,000     100,000          --              35,000(12)                 --       
Biopharmaceutical               1996    165,000     100,000          --              75,000(12)                 --       
Operations                                                                                                     
    
</TABLE>

(1)   Amounts shown include compensation  deferred pursuant to Section 401(k) of
      the Internal Revenue Code of 1986, as amended (the "Code").

(2)   Although the Company has no formal bonus plan, the Compensation Committee,
      in its  discretion,  may award  bonuses to  officers of the  Company.  The
      Company has paid  bonuses  based on  individual  and Company  performance.
      Amounts shown include awards paid relative to services rendered in each of
      the last three fiscal  years.  All bonus awards for each of the last three
      fiscal  years were paid in cash.  Bonuses are  recorded  for the period in
      which they were earned.

(3)   Excludes  perquisites  and other personal  benefits for each Named Officer
      which  did not  equal or  exceed  the  lesser  of  $50,000  or 10% of such
      individual's  base salary and bonus for the years ended December 31, 1998,
      1997 and 1996, respectively.

(4)   Options or warrants to purchase the number of shares of common stock shown
      are  recorded  for the  period  in which  they  were  granted,  except  as
      discussed in footnote 6.


                                       14
<PAGE>

(5)   During 1996,  Dr. Samuel D. Waksal was paid a $100,000  bonus  relating to
      his 1996 performance.  During 1996, the Compensation  Committee determined
      to consider the payment to him of an additional  bonus, in an amount to be
      determined,  subject to the  Company's  completion  by June 30,  1997 of a
      corporate partnership,  or similar arrangement,  with acceptable terms. In
      connection with the December 1997 amendment of the Company's BEC2 Research
      and  License  Agreement  with  Merck  KGaA  and  sale  to  Merck  KGaA  of
      $40,000,000 of the Company's  Series A preferred  stock,  the Compensation
      Committee determined to extend the June 30, 1997 period, and Dr. Samuel D.
      Waksal was paid a bonus of  $100,000.  This amount is  reflected as a 1996
      bonus.

(6)   Options to purchase  250,000,  100,000 and 25,000  shares of common stock,
      respectively,  held by Drs. Samuel D. Waksal, Harlan W. Waksal and Carl S.
      Goldfischer, respectively, were granted in January 1998 and relate to 1997
      performance.

(7)   Consists  of  premium  payments  on a term life  insurance  policy for Dr.
      Samuel D. Waksal under which his daughters are the beneficiaries.

(8)   During 1996,  Dr. Harlan W. Waksal was paid a $100,000  bonus  relating to
      his 1996 performance.  During 1996, the Compensation  Committee determined
      to consider the payment to him of an additional  $100,000 bonus at the end
      of the  six  month  period  ending  June  30,  1997.  In  June  1997,  the
      Compensation  Committee  determined to award such additional  bonus to Dr.
      Harlan W. Waksal. This amount is reflected as a 1996 bonus.

(9)   In March  1997,  the  Board  extended  the term of a warrant  to  purchase
      397,000  shares of common stock held by Dr. Harlan W. Waksal which was due
      to  expire.  The term was  extended  for a period of two years on the same
      terms and  conditions as the original  grant.  For purposes of this table,
      this  extension  is treated as a new warrant  grant.  In April  1997,  Dr.
      Harlan W. Waksal exercised this warrant.

(10)  Dr. Goldfischer  commenced employment with the Company on May 20, 1996 and
      has resigned from the Company with an expected  effective  date of the end
      of May 1999.

(11)  Dr. Gilly ceased employment with the Company as of December 31, 1998.

(12)  These options  terminated  unexercised as to 135,000 shares,  0 shares and
      75,000,  respectively,   in  connection  with  Dr.  Gilly's  cessation  of
      employment with the Company as of December 31, 1998.


                                       15
<PAGE>

                          OPTION GRANTS IN FISCAL 1998

         The following  table sets forth certain  information  relating to stock
option grants to the Named Officers during the year ended December 31, 1998.

<TABLE>
<CAPTION>
                                % of Total
                  Number of     Options/
                  Securities    Warrants                                             Potential Realizable
                  Underlying    Granted to                                      Value at Assumed Annual Rates of
                  Options/      Employees                                           Stock Price Appreciation
                  Warrants      in Fiscal    Exercise Price                         for Option/Warrant Term (3)
      Name        Granted       Year(1)       ($/share)(2)   Expiration Date    0%($)       5%($)        10%($)       
      ----        ---------    -------        ------------   ---------------    ---------------------------------------           
<S>               <C>            <C>            <C>          <C>                          <C>           <C>                       
   
Samuel D. Waksal  300,000(4)     15%         $  11.375       May 25, 2008      ----    $  1,321,719$    4,125,953
    

Harlan W. Waksal  250,000(4)     13%            11.375       May 25, 2008      ----       1,101,433     3,438,294
                                                                                      

John B. Landes                    7%            11.375       May 25, 2008      ----
                  135,000(4)                                                                594,774     1,856,679

Carl S.           125,000(4)      6%            11.375       May 25, 2008      ----
Goldfischer                                                                                 550,716     1,719,147

John A. Gilly     135,000(5)      7%            11.375         ----            ----         ----        ----
</TABLE>

   
(1)   The Company  granted  options to purchase a total of  1,889,500  shares of
      common stock to employees  during 1998.  This number  excludes  options to
      purchase a total of 375,000  granted  in  January  1998 to Drs.  Samuel D.
      Waksal,  Harlan W. Waksal and Carl S.  Goldfischer  because they relate to
      1997 performance and have previously been reported as 1997 compensation.
    

(2)   All options  were granted to purchase  common  stock at an exercise  price
      that  equaled or exceeded the fair market value of the common stock on the
      date of grant.

(3)   The amounts set forth in the three columns  represent  hypothetical  gains
      that might be  achieved  by the  holders  if the  respective  options  are
      exercised  at the end of their  terms.  These  gains are based on  assumed
      rates of stock price  appreciation  of 0%, 5% and 10% compounded  annually
      from the dates the respective  options were granted.  The 0%  appreciation
      column is included  because the options were granted with exercise  prices
      which equaled or exceeded the fair market value of the  underlying  common
      stock on the  date of  grant,  and thus  will  have no  value  unless  the
      Company's stock price increases above the exercise prices.

(4)   These options vest and become exercisable as to 40% on May 26, 1999, as to
      an  additional  30% on May 26, 2000 and as to the remaining 30% on May 26,
      2001,  subject to the respective  holder's  continued  employment with the
      Company on the relevant vesting date.

(5)   This option  terminated in its entirety  unexercised  on December 31, 1998
      due to Dr. Gilly's ceasing to be employed by the Company.


                                       16
<PAGE>

             OPTION AND WARRANT EXERCISES AND VALUES FOR FISCAL 1998

      The  following  table sets forth option and warrant  exercises  during the
year ended  December 31, 1998 by the Named Officers and the value of the options
and  warrants  held by  such  persons  on  December  31,  1998,  whether  or not
exercisable on such date.

<TABLE>
<CAPTION>
                                                    Number of Shares Underlying          Value of Unexercised
                       Shares                       Unexercised Options/Warrants    In-The-Money Options/Warrants at
                     Acquired on       Value           at December 31, 1998(#)          December 31, 1998($)(2)
Name                 Exercise(#)  Realized($)(1)    Exercisable    Unexercisable    Exercisable       Unexercisable
- ----                 -----------  --------------    -----------    -------------    -----------       -------------
<S>                     <C>          <C>            <C>              <C>             <C>                <C>
Samuel D. Waksal        87,305     $ 436,525        395,000          550,000        $ 1,247,050        $ 750,000

Harlan W. Waksal        ----          ----          380,680          350,000          2,578,715          300,000

John B. Landes          23,000       144,260        144,000          150,000            863,127           ----

Carl S. Goldfischer     ----          ----          166,666          208,334            127,166          119,509

John A. Gilly(3)        50,000       202,939         ----             ----               ----             ----
</TABLE>

(1)   The values  realized were  calculated by  multiplying  the closing  market
      price of the common stock on the date of exercise by the respective number
      of  shares  exercised  and  subtracting  the  aggregate   exercise  price.
      Accordingly,  such values  realized  assume a sale of such common stock on
      the date of exercise, which may not necessarily have occurred.

(2)   The values were  calculated by multiplying the closing market price of the
      common  stock on December  31,  1998  ($9.063 per share as reported by the
      Nasdaq  National  Market on that date) by the respective  number of shares
      and  subtracting  the  aggregate   exercise  price,   without  making  any
      adjustments for vesting,  termination contingencies or other variables. If
      the  exercise  price of an option or warrant  is equal to or greater  than
      $9.063 the option or warrant is deemed to have no value.

(3)   John A. Gilly  ceased to be employed  by the  Company as of  December  31,
      1998.  On this  date  all his  unexercised  options  terminated  in  their
      entirety.

Other Benefit Plans

      The  Company  has no defined  benefit or defined  contribution  retirement
plans other than the ImClone Systems  Incorporated  401(k) Employee Savings Plan
(the "Plan") established under Section 401(k) of the Code.  Contributions to the
Plan are voluntary,  and substantially  all full-time  employees are eligible to
participate.  For 1999,  the  Company  has  elected to make  voluntary  matching
contributions   equal  to  25%  of  the  first  4%  of  an  employee's  eligible
compensation  contributed by the employee,  limited to $2,500 per employee.  The
Company made such a matching  contribution for 1998 which totaled  $47,000.  The
Company anticipates evaluating the level of its matching  contribution,  if any,
on an annual basis.


                                       17
<PAGE>

                             STOCK PRICE PERFORMANCE

      The graph below  provides a  comparison  of the  cumulative  total  return
(assuming  reinvestment of dividends) for the Company (which paid no dividends),
The Nasdaq Stock  Market (U.S.  Companies)  Total Return  Index,  and the Nasdaq
Pharmaceutical  Stocks Total Return Index for the period from  December 31, 1993
through December 31, 1998. The graph assumes $100 was invested in ImClone common
stock and each of the indexes at the beginning of such period.  The Nasdaq Stock
Market (U.S.  Companies) Total Return Index comprises all domestic common shares
traded on the Nasdaq National Market and the Nasdaq SmallCap Market.  The Nasdaq
Pharmaceutical  Stocks Total Return Index  represents all  companies,  including
biotechnology  companies,  trading  on  Nasdaq  classified  under  the  Standard
Industrial Classification Code for pharmaceuticals.

                   COMPARISON OF FIVE YEAR TOTAL RETURN AMONG
   IMCLONE, NASDAQ STOCK MARKET (U.S. COMPANIES) TOTAL RETURN INDEX AND NASDAQ
                    PHARMACEUTICAL STOCKS TOTAL RETURN INDEX

         Date           ImClone Systems            Nasdaq         Pharmaceutical
     --------------     ---------------       ----------------  ----------------
       12/31/93               100                   100                    100
       12/31/94                15                    98                     75
       12/31/95               124                   138                    138
       12/31/96               159                   170                    138
       12/31/97               133                   209                    143
       12/31/98               148                   293                    183


                                       18
<PAGE>

                                 PROPOSAL NO. 2

     APPROVAL OF AMENDMENT TO THE COMPANY'S 1996 INCENTIVE STOCK OPTION PLAN

      In February 1996,  the Company's  Board adopted the 1996 ISO Plan in order
to enable the Company to attract and retain key executives  and other  employees
and to promote the interests of the Company. Subject to shareholder approval, on
March 29, 1999, the Board  approved  amendments to the 1996 ISO Plan to increase
the total  number of shares of  common  stock  which may be issued  pursuant  to
options  granted  under the 1996 ISO Plan from  3,000,000  to  4,000,000,  which
number shall be reduced by the number of shares which have been or may be issued
pursuant to options granted under the 1996 Non-Qualified Plan.

   
      The Board  believes that a key  ingredient in  attracting,  motivating and
retaining  qualified  executives  and other  employees  is to offer  significant
potential rewards based upon the Company's success through the issuance of stock
options.  The  amendment  to the 1996 ISO Plan  increasing  the shares of common
stock  authorized  under the plan and  presented to the  stockholders  for their
approval is designed to assist the Company in  accomplishing  this goal.  Of the
3,000,000 shares of common stock currently authorized in the aggregate under the
1996 ISO Plan and the 1996 Non-Qualified  Plan, at April 1, 1999 an aggregate of
58,592 shares remained available for future grants.

      The following summary description of the 1996 ISO Plan is qualified in its
entirety  by the full  text of the 1996 ISO Plan  which may be  obtained  by the
Company's  stockholders  upon request to the Secretary of the Company.  The 1996
ISO Plan has been approved by the Board and by the shareholders.

      The last sale price of a share of the  Company's  common stock as reported
by the Nasdaq National Market on April 8, 1999 was $17.00.
    

      Purpose of the Plan.  The  purpose of the 1996 ISO Plan is to promote  the
interests of the Company by affording key executives and other  employees of the
Company an opportunity to acquire a proprietary interest in the Company pursuant
to stock  options  issued by the  Company,  and thus to  create in such  persons
increased personal interest in its continued success.

   
      Administration  of the  Plan.  The 1996 ISO  Plan is  administered  by the
Compensation  Committee,  comprised of not less than two persons. The members of
the  Compensation  Committee  serve at the pleasure of the Board,  which has the
power at all times to remove members from the  Compensation  Committee or to add
members thereto.  Vacancies in the Compensation  Committee,  however caused, are
filled  by  action  of  the  Board.  All  decisions  or  determinations  of  the
Compensation  Committee  are made by the majority vote or decision of all of its
members.  The interpretation  and construction by the Compensation  Committee of
the  provisions of the 1996 ISO Plan or of the options  granted  thereunder  are
final unless otherwise determined by the Board.
    

      Eligibility to Participate in the Plan. Key executives and other employees
of the Company are eligible for the grant of options under the 1996 ISO Plan.

   
      Common  Stock  Subject  to the Plan.  Currently,  the  number of shares of
common stock to be issued or sold pursuant to options granted under the 1996 ISO
Plan may not exceed 3,000,000 shares,  less the number of shares of common stock
to be issued or sold pursuant to options  granted  under the 1996  Non-Qualified
Plan. The  shareholders are being asked to amend the 1996 ISO Plan (and the 1996
Non-Qualified  Plan) at the meeting to increase  this  number to  4,000,000.  At
April 1, 1999 an  aggregate  of 58,592  shares  remained  available  for  future
grants.
    

      If any  change is made in the shares of common  stock  subject to the 1996
ISO Plan or  subject  to any  option  granted  under the 1996 ISO Plan  (through
merger,  consolidation,   reorganization,   recapitalization,   stock  dividend,
split-up,  combination  of shares,  exchange  of shares,  issuance  of rights to
subscribe,  or change in capital  structure),  appropriate  adjustments shall be
made by the Compensation Committee as to the maximum number of shares subject to
the 1996 ISO Plan and the  number of shares  and  price  per  share  subject  to
outstanding  options as shall be equitable to prevent dilution or enlargement of
option rights. Any such  determination made by the Compensation  Committee shall
be final, binding and conclusive upon each participant.


                                       19
<PAGE>

      Amendments or Discontinuation of the1996 ISO Plan. The Board may make such
amendments,  changes and additions to the 1996 ISO Plan, or may  discontinue and
terminate  the  1996  ISO  Plan,  as it may deem  advisable  from  time to time;
provided,  however,  that no action may affect or impair any options theretofore
granted under such plan, and provided,  further,  however,  that the affirmative
vote of the  owners of a  majority  of the  outstanding  shares of common  stock
present at a meeting in person or by proxy and  entitled  to vote at the meeting
shall be  necessary  to effect any  amendment  to the 1996 ISO Plan which  would
increase the number of shares of common stock  subject to options  granted under
such plan or which would authorize  incentive stock options at a price below the
fair market value (or 110%  thereof,  if the employee  owns more than 10% of the
voting  securities  of the  Company  at the time of the  grant) of the shares of
common stock subject to the option.

      ERISA.  The 1996 ISO Plan is not subject to any  provision of the Employee
Retirement Income Security Act of 1974, as amended ("ERISA").

Description of Options

      Nontransferability.  Options granted pursuant to the 1996 ISO Plan are not
transferable by the holder thereof,  other than by will, the laws of descent and
distribution,  or (if  authorized  in the  applicable  stock  option  agreement)
pursuant  to a qualified  domestic  relations  order,  as defined by the Code or
Title I of ERISA or the rules thereunder.

      Granting of Options.  The  Compensation  Committee shall determine the key
executives  and other  employees to be granted  options under the 1996 ISO Plan,
the number of shares of common  stock  subject  to such  options,  the  exercise
prices of options,  the terms thereof and any other  provisions not inconsistent
with the 1996 ISO Plan. To the extent the aggregate  fair market value of common
stock with respect to which  incentive  stock  options are  exercisable  for the
first  time by any  holder  during  any  calendar  year  (under all plans of the
Company and its parent and subsidiary corporations) exceeds $100,000 (based upon
the fair  market  value of such  common  stock on the date of the  grant of such
options),  those  options  exercisable  with respect to those  shares  valued in
excess of $100,000 will be treated as  non-qualified  stock  options.  All stock
options granted pursuant to the 1996 ISO Plan shall be evidenced by stock option
agreements, which need not be identical, between the Company and the participant
in such form as the  Compensation  Committee  shall  from time to time  approve,
subject to the terms of the 1996 ISO Plan.  Each stock  option  agreement  shall
state the total  number of shares  of common  stock  with  respect  to which the
option is granted,  the terms and  conditions  of the option,  and the  exercise
price or prices thereof.

      Life of the Plan.  Options  may be  granted  under the 1996 ISO Plan until
February 25, 2006.

      Exercise  Price.  The price at which the shares of common stock subject to
each option granted under the 1996 ISO Plan may be purchased (the "option price"
or "exercise  price") shall be determined by the Compensation  Committee,  which
shall have the  authority  at the time the option is granted to prescribe in any
stock  option  agreement  that  the  price  per  share,   with  the  passage  of
pre-determined periods of time, shall increase from the original price to higher
prices.  In no event may the exercise  price of an option granted under the 1996
ISO Plan be less than 100%  (110% in the case of 10%  stockholders)  of the fair
market value of the common stock on the date of the grant. The exercise price of
all options granted under the 1996 ISO Plan is payable in full upon the exercise
of such option,  which  payment shall be in cash, by check or in stock (that has
been owned by the  participant for at least six months) or notes of the Company,
or, as agreed to by the Board, other consideration.  In the case of payment made
in stock of the Company,  the stock shall be valued at its Fair Market Value (as
hereinafter defined) on the last business day prior to the date of exercise. The
term "Fair Market Value" for the common stock on any particular  date shall mean
the last  reported  sale price of the common  stock on the  principal  market on
which the common  stock trades on such date or, if no trades of common stock are
made or  reported  on such date,  then on the next  preceding  date on which the
common stock traded.

   
      Terms  and  Conditions  of  Exercise;   Exercise  Period.  The  terms  and
conditions of any option granted under the 1996 ISO Plan and the exercise period
are  governed by the option  agreement  between the holder of the option and the
Company. Subject to the limitations set forth in the 1996 ISO Plan, the terms of
such option  agreements,  including the exercise  period,  are determined by the
Compensation  Committee  and need not be  uniform  among  recipients  of similar
options.  Options granted pursuant to the 1996 ISO Plan may be exercised only if
the  participant  was, at all times during the period  beginning on the date the
option was granted and ending on the date of such  exercise,  an employee of the
Company.  The right to exercise any  unexercised  portion of any option  granted
    


                                       20
<PAGE>

under  the  1996  ISO  Plan  terminates  on  the  date  of  termination  of  the
relationship  between the participant and the Company,  for any reason,  without
regard to cause, other than by reason of death or disability except as otherwise
provided in connection with a particular option or a particular termination. The
option may not be exercised  thereafter,  and the shares of common stock subject
to the  unexercised  portion of such  option may again be subject to new options
under the 1996 ISO Plan. In the event a participant dies or is disabled while he
is an employee of the Company,  any options  theretofore granted to him shall be
exercisable only within the next 12 months immediately  succeeding such death or
disability  and then only (a) in the case of death,  by the person or persons to
whom the  participants  right's under such option shall pass by will or the laws
of descent and distribution,  and in the case of disability, by such participant
or his legal  representatives  and (b) if and to the extent that he was entitled
to  exercise  such  option  at the date of his  death or  disability  except  as
otherwise  provided  in  connection  with a  particular  option or a  particular
individual's  death or  disability.  The maximum  option term under the 1996 ISO
Plan is ten years after the date of grant.

U.S. Federal Income Tax Consequences

      The  following is a summary of the U.S.  Federal  income tax  consequences
under  current tax law  (without  regard to any proposed  changes,  which may be
retroactive in effect) with respect to incentive  stock options  granted to U.S.
employees  under the 1996 ISO Plan.  For this  purpose,  it is assumed  that the
shares  acquired  pursuant to the exercise of an option are held by the optionee
as a capital asset. Certain other rules not discussed herein apply to the use of
previously  acquired  shares of common  stock in payment of the option  exercise
price.

      Options  granted  under the 1996 ISO Plan are  intended  to be  "incentive
stock options" described in Section 422 of the Code.

      Incentive Stock Options.  In general, no taxable income will be recognized
by an optionee  upon the grant or exercise of an  incentive  stock  option.  The
optionee's  tax basis in the shares  received on the  exercise of such an option
will be equal to the option price paid by the optionee for such shares.

      If the stock  received upon exercise of an incentive  stock option is held
more than one year after the date of transfer of such shares to the optionee and
more  than two  years  from the  date of grant of the  option,  any gain or loss
recognized  by the  optionee  on the  subsequent  sale  of the  stock  will be a
long-term  capital gain or loss, as the case may be. If the shares received upon
the  exercise of an  incentive  stock option are disposed of prior to the end of
such holding periods, an amount equal to the excess (if any) of (a) the lower of
the  disposition  price or the fair  market  value of such shares on the date of
exercise of the incentive  stock option,  over (b) the  optionee's  tax basis in
such shares will be treated as ordinary  income,  and any further gain will be a
short-term or long-term  capital gain  depending upon the period the shares were
held.  Any  loss on the  disposition  of such  shares  will be a  short-term  or
long-term capital loss depending upon the period the shares were held.

      Cancellation or Surrender.  Consideration received by an optionee upon the
surrender to, or cancellation  by, the Company of an incentive stock option will
be taxable as ordinary income to the optionee and generally allowed as an income
tax deduction to the Company.

      Alternative   Minimum   Tax.  In  addition  to  the  Federal   income  tax
consequences  described  above,  an  optionee  may be  subject  to  the  Federal
alternative  minimum tax. In general,  upon the exercise of any incentive  stock
option an amount  equal to the  excess of the fair  market  value of the  shares
acquired on the exercise date over the exercise price will be treated as an item
of adjustment  for purposes of the  alternative  minimum tax. If,  however,  the
shares are disposed of in the same  taxable  year in which the exercise  occurs,
the  maximum  amount  that will be treated as an item of  adjustment  will be an
amount equal to the excess of the amount received upon such disposition over the
exercise price.

      The  forgoing  does not  purport to be a complete  summary of the  federal
income tax  considerations  that may be relevant to holders of options or to the
Company.  It also does not  reflect  provisions  of the  income  tax laws of any
municipality, state or foreign country in which an optionee may reside, nor does
it reflect the tax consequences of an optionee's death.


                                       21
<PAGE>

New Plan Benefits

      The  benefits or amounts  that will be received or allocated in the future
under the 1996 ISO Plan are not determinable.

   
      The Board  recommends a vote "FOR"  approval of the  amendment to the 1996
ISO Plan to  increase  the total  number of shares of common  stock which may be
issued  pursuant  to options  which may be granted  under the 1996 ISO Plan from
3,000,000 to 4,000,000, which number shall be reduced by the number of shares of
common stock which have been or may be issued  pursuant to options granted under
the 1996 Non-Qualified Plan. (Proposal No. 2 on your proxy card).
    


                                       22
<PAGE>

                                 PROPOSAL NO. 3

   
       APPROVAL OF AMENDMENTS TO THE 1996 NON-QUALIFIED STOCK OPTION PLAN
    

         In February  1996, the Company's  Board adopted the 1996  Non-Qualified
Plan in order to enable the Company to attract and retain key executives,  other
employees,  advisors,  consultants and directors and to promote the interests of
the Company by affording  such persons an  opportunity  to acquire a proprietary
interest in the Company. Subject to shareholder approval, on March 29, 1999, the
Board approved  amendments to the 1996  Non-Qualified Plan to increase the total
number of shares of common stock which may be issued pursuant to options granted
under the 1996  Non-Qualified  Plan from  3,000,000 to  4,000,000,  which number
shall be  reduced  by the  number  of  shares  which  have been or may be issued
pursuant to options granted under the 1996 ISO Plan.

      The Board  believes  that a key  ingredient in  attracting,  retaining and
motivating  key  executives  and  other  employees,  advisors,  consultants  and
directors is to offer  significant  potential  rewards  based upon the Company's
success  through  the  issuance  of stock  options.  The  amendment  to the 1996
Non-Qualified Plan increasing the shares of common stock authorized for issuance
presented  herein to the  stockholders  for their approval is designed to assist
the Company in accomplishing  this goal. Of the 3,000,000 shares of common stock
currently  authorized  under the 1996  Non-Qualified  Plan and 1996 ISO Plan, at
April 1, 1999 an  aggregate  of 58,592  shares  remained  available  for  future
grants.

      The  following  summary  description  of the  1996  Non-Qualified  Plan is
qualified in its entirety by the full text of the 1996  Non-Qualified Plan which
may be obtained by the Company's  stockholders  upon request to the Secretary of
the Company.  The 1996  Non-Qualified Plan has been approved by the Board and by
the shareholders.

   
      The last sale price of a share of the  Company's  common stock as reported
by the Nasdaq National Market on April 8, 1999 was $17.00.
    

      Purpose  of the Plan.  The  purpose of the 1996  Non-Qualified  Plan is to
promote  the  interests  of the  Company  by  affording  key  executives,  other
employees,  consultants, advisors and directors of the Company an opportunity to
acquire a proprietary  interest in the Company  pursuant to stock options issued
by the Company and thus to create in such persons increased personal interest in
its continued success.

      Administration of the Plan. The 1996 Non-Qualified Plan is administered by
the  Compensation  Committee  and is  comprised of not less than two persons who
shall be appointed by the Board from among the members of the Board. The members
of the Compensation  Committee serve at the pleasure of the Board, which has the
power at all times to remove members from the  Compensation  Committee or to add
members thereto.  Vacancies in the Compensation  Committee,  however caused, are
filled  by  action  of  the  Board.  All  decisions  or  determinations  of  the
Compensation  Committee  are made by the majority vote or decision of all of its
members.  The interpretation  and construction by the Compensation  Committee of
the  provisions  of  the  1996  Non-Qualified  Plan  or of the  options  granted
thereunder are final unless otherwise determined by the Board.

      Eligibility to Participate in the Plan. Key executives,  other  employees,
consultants, advisors and directors of the Company are eligible for the grant of
options under the 1996 Non-Qualified Plan.

   
      Common  Stock  Subject  to the Plan.  Currently,  the  number of shares of
common  stock to be issued or sold  pursuant to options  granted  under the 1996
Non-Qualified Plan may not exceed 3,000,000 shares, less the number of shares of
common stock to be issued or sold pursuant to options granted under the 1996 ISO
Plan. The shareholders are being asked to amend the 1996 Non-Qualified Plan (and
the 1996 ISO Plan) at the meeting to increase this number to 4,000,000. At April
1, 1999 an aggregate of 58,592 shares remained available for future grants.
    

      If any  change is made in the shares of common  stock  subject to the 1996
Non-Qualified Plan or subject to any option granted under the 1996 Non-Qualified
Plan (through merger,  consolidation,  reorganization,  recapitalization,  stock
dividend,  split-up,  combination  of shares,  exchange  of shares,  issuance of
rights to subscribe,  or change in capital structure),  appropriate  adjustments
shall be made by the  Compensation  Committee as to the maximum number of shares
subject  to the 1996  Non-Qualified  Plan and the number of shares and price per
share


                                       23
<PAGE>

subject to  outstanding  options as shall be  equitable  to prevent  dilution or
enlargement of option rights.  Any such  determination  made by the Compensation
Committee shall be final, binding and conclusive upon each participant.

   
      Amendments  or  Discontinuation  of the  Plan.  The  Board  may make  such
amendments,  changes  and  additions  to the  1996  Non-Qualified  Plan,  or may
discontinue and terminate the 1996 Non-Qualified  Plan, as it may deem advisable
from time to time;  provided,  however,  that no action may affect or impair any
options  theretofore  granted under such plan, and provided,  further,  however,
that the affirmative vote of the owners of a majority of the outstanding  shares
of common stock  present at a meeting in person or by proxy and entitled to vote
at the  meeting  shall  be  necessary  to  effect  any  amendment  to  the  1996
Non-Qualified  Plan which would  increase  the number of shares of common  stock
subject to options granted under such plan.
    

      ERISA.  The 1996  Non-Qualified  Plan is not subject to any  provision  of
ERISA.

Description of Options

      Nontransferability.  Options  granted  pursuant to the 1996  Non-Qualified
Plan are not transferable by the holder thereof, other than by will, the laws of
descent and  distribution,  or (if  authorized  in the  applicable  stock option
agreement)  pursuant to a qualified  domestic relations order, as defined by the
Code or Title I of ERISA or the rules thereunder.

      Granting of Options.  The  Compensation  Committee shall determine the key
executives, other employees,  consultants,  advisors and directors to be granted
options under the 1996 Non-Qualified  Plan, the number of shares of common stock
subject to such options,  the exercise prices of options,  the terms thereof and
any other  provisions not  inconsistent  with the 1996  Non-Qualified  Plan. All
stock options granted pursuant to the 1996 Non-Qualified Plan shall be evidenced
by stock option agreements, which need not be identical, between the Company and
the  participant in such form as the  Compensation  Committee shall from time to
time approve,  subject to the terms of the 1996  Non-Qualified  Plan. Each stock
option  agreement  shall state the total  number of shares of common  stock with
respect to which the option is granted,  the terms and conditions of the option,
and the exercise price or prices thereof.

      The Non-Qualified  Plan provides that annually,  on February 15 of each of
the Company's fiscal years, any director of the Company who at the time is not a
full-time  employee  of  the  Company  (a  "Participating   Director")  will  be
automatically   granted  an  option  for  2,500   shares  of  common   stock  (a
"Participating  Director  Option").  Each  person  who  becomes a  Participating
Director after the first day of the Company's fiscal year and within nine months
of that date will be granted,  on the date that person  becomes a  Participating
Director, a Participating Director Option for a number of shares of common stock
determined  by pro rating the normal  2,500  share  annual  amount  based on the
period of time  remaining  in the  fiscal  year in which such  person  becomes a
Participating Director. No person who owns 10% or more of the outstanding common
stock of the Company (including shares of common stock issuable upon exercise of
outstanding  options  and  warrants)  will  be  granted  Participating  Director
Options.  The  shareholders  are being asked  pursuant to this Proposal No. 3 to
amend the 1996  Non-Qualified  Plan at the meeting to increase the Participating
Director  Option from 2,500 to 15,000 for  Participating  Directors  (except the
Chairman)  and from  2,500  to  30,000  for the  Chairman,  commencing  with the
February 2000 Participating Director Option.

      Life of the Plan. Options may be granted under the 1996 Non-Qualified Plan
until June 3, 2006.

      Exercise  Price.  The price at which the shares of common stock subject to
each option (other than  Participating  Director Options) granted under the 1996
Non-Qualified  Plan may be purchased  (the "option  price" or "exercise  price")
shall  be  determined  by the  Compensation  Committee,  which  shall  have  the
authority  at the time the option is granted to  prescribe  in any stock  option
agreement that the price per share, with the passage of  pre-determined  periods
of time, shall increase from the original price to higher prices.  Participating
Director  Options  have an exercise  price equal to the fair market value of the
common stock on the date of the grant. The exercise price of all options granted
under the 1996  Non-Qualified  Plan is payable in full upon the exercise of such
option,  which  payment  shall be in cash,  by check or in stock  (that has been
owned by the participant  for at least six months) or notes of the Company,  or,
as agreed to by the Board, other  consideration.  In the case of payment made in
stock of the  Company,  the stock shall be valued at its Fair  Market  Value (as
hereinafter defined) on the last business day prior to the date of exercise. The
term "Fair Market Value" for the common stock on any particular  date shall mean
the last  reported  sale price of the common  stock on the  principal  market on
which the common  stock trades on such date


                                       24
<PAGE>

or, if no trades of common stock are made or reported on such date,  then on the
next preceding date on which the common stock traded.

      Terms  and  Conditions  of  Exercise;   Exercise  Period.  The  terms  and
conditions  of any  option  granted  under the 1996  Non-Qualified  Plan and the
exercise period are governed by the option  agreement  between the holder of the
option  and the  Company.  Subject  to the  limitations  set  forth  in the 1996
Non-Qualified Plan, the terms of such option agreements,  including the exercise
period,  are  determined by the  Compensation  Committee and need not be uniform
among recipients of similar options.  Options (other than Participating Director
Options) granted pursuant to the 1996  Non-Qualified  Plan may be exercised only
if the participant was, at all times during the period beginning on the date the
option  was  granted  and  ending on the date of such  exercise,  an  advisor or
consultant to or director or employee of the Company.  The right to exercise any
unexercised  portion of any option (other than Participating  Directors Options)
granted under the 1996  Non-Qualified Plan terminates on the date of termination
of the  relationship  between the participant  and the Company,  for any reason,
without regard to cause, other than by reason of death or disability,  except as
otherwise  provided  in  connection  with a  particular  option or a  particular
termination.  The  option  may not be  exercised  thereafter,  and the shares of
common  stock  subject to the  unexercised  portion of such  option may again be
subject  to new  options  under  the 1996  Non-Qualified  Plan.  In the  event a
participant  dies or is disabled  while he is an advisor or  consultant  to or a
director or  employee of the  Company,  any  options  (other than  Participating
Director  Options)  theretofore  granted to him shall be exercisable only within
the next 12 months immediately succeeding such death or disability and then only
(a) in the case of death,  by the  person or  persons  to whom the  participants
rights  under  such  option  shall  pass  by will or the  laws  of  descent  and
distribution,  and in the case of disability,  by such  participant or his legal
representatives  and (b) if and to the extent  that he was  entitled to exercise
such option at the date of his death or disability except as otherwise  provided
in connection  with a particular  option or a particular  individual's  death or
disability.  Participating  Director  Options remain  exercisable  for ten years
after the date of grant and the option  holder (or his legal  representative  or
that of his estate) may continue to exercise an option  notwithstanding that the
holder ceases to be a Participating  Director. The maximum option term under the
1996 Non-Qualified Plan is ten years after the date of grant.

U.S. Federal Income Tax Consequences

      The  following is a summary of the U.S.  Federal  income tax  consequences
under  current tax law  (without  regard to any proposed  changes,  which may be
retroactive in effect) with respect to  non-qualified  stock options  granted to
U.S. key executives, other employees,  advisors,  consultants or directors under
the 1996  Non-Qualified  Plan.  For this purpose,  it is assumed that the shares
acquired  pursuant to the  exercise  of an option are held by the  optionee as a
capital  asset.  Certain  other  rules not  discussed  here  apply to the use of
previously  acquired  shares of common  stock in payment of the option  exercise
price.

      The 1996  Non-Qualified  Plan is not qualified under Section 401(a) of the
Code.

      Non-Qualified Options. No taxable income will be recognized by an optionee
upon the grant of a non-qualified stock option. Upon the exercise of the option,
the excess of the fair market  value of the shares at the time of such  exercise
over the exercise price will be treated as compensation.  Any amounts treated as
compensation  (i) will be taxable as ordinary  income to the  optionee  and (ii)
generally  will be  allowed  as an income  tax  deduction  to the  Company.  The
optionee's  tax basis for shares  acquired  upon  exercise of the option will be
increased by any amounts so treated as compensation.

      Any gain or loss realized by an optionee on the subsequent  sale of shares
acquired upon the exercise of a non-qualified stock option will be short-term or
long-term capital gain depending on the period the shares were held.

      Cancellation or Surrender.  Consideration received by an optionee upon the
surrender to, or cancellation  by, the Company of a  non-qualified  stock option
will be taxable as ordinary  income to the optionee and generally  allowed as an
income tax deduction to the Company.

New Plan Benefits

      Other than option grants of Participating  Director Options,  the benefits
or amounts  that will be  received  or  allocated  in the future  under the 1996
Non-Qualified Plan are not determinable.


                                       25
<PAGE>

      The Board  recommends  a vote "FOR"  approval  of  amendments  to the 1996
Non-Qualified  Plan to (i) increase the number of shares of the Company's common
stock  which may be issued  pursuant to options  which may be granted  under the
1996  Non-Qualified  Plan from  3,000,000  to  4,000,000,  which number shall be
reduced by the number of shares of common stock which have been or may be issued
pursuant  to options  granted  under the 1996 ISO Plan,  and (ii)  increase  the
annual option grant made to  non-employee  members of the Board of Directors and
the non-employee Chairman under the 1996 Non-Qualified Plan from 2,500 to 15,000
and from 2,500 to 30,000, respectively. (Proposal No. 3 on your proxy card).


                                       26
<PAGE>

                                 PROPOSAL NO. 4

          APPROVAL TO AMEND THE COMPANY'S CERTIFICATE OF INCORPORATION
           TO INCREASE THE NUMBER OF AUTHORIZED SHARES OF COMMON STOCK

   
      At  present,  the  Company is  authorized  to issue two classes of capital
stock  consisting  of  common  stock  with a par  value of $.001  per  share and
preferred stock with a par value of $1.00 per share. 45,000,000 shares of common
stock and 4,000,000  shares of preferred stock are currently  authorized.  As of
April 1, 1999,  400,000 shares of preferred stock were  outstanding and had been
designated as Series A convertible  preferred  stock.  As of April 1, 1999 there
were approximately:
    

      o     24,668,175 shares of common stock issued and outstanding.

      o     4,559,099  shares of common stock  reserved for issuance for options
            issued and outstanding, including under the Company's various option
            plans.

      o     2,263,590  shares of common stock reserved for issuance  pursuant to
            outstanding warrants.

      o     761,557  shares of common  stock  reserved  for  issuance  under the
            Company's  various  option plans and 1998  Employee  Stock  Purchase
            Plan.

   
      o     2,700,826  shares of common stock reserved for issuance  pursuant to
            400,000  shares of  outstanding  Series A preferred  stock issued in
            December 1997 for an aggregate of $40,000,000. 100,000 of the Series
            A preferred  stock  could be  immediately  converted  into shares of
            common stock  beginning on December 15, 1997. An additional  100,000
            will be able to be converted into shares of common stock on or after
            each of January 1, 2000,  January 1, 2001 and  January 1, 2002.  Any
            Series A preferred  stock converted into common stock before January
            1, 2000 will be converted at a conversion  price of $12.50 per share
            of common  stock.  After that,  the number of shares of common stock
            into which shares of Series A preferred stock are convertible is not
            fixed.  Instead,  the conversion price is determined under a formula
            based  upon the  market  price  of our  common  stock  at  specified
            measurement  dates,  which are  generally  one year apart.  Because,
            except for the first  tranche,  the exact number of shares needed to
            be  reserved  cannot be  determined  due to the  fluctuating  market
            price, the Company has currently reserved a number of shares for the
            first  tranche  equal to  800,000  and a number  of  shares  for all
            subsequent  tranches based upon the market price at April 1, 1999. A
            different  number of shares could be required based on  fluctuations
            in the price of the common stock.
    

      o     1,652,892  shares of common stock reserved for issuance as shares of
            common  stock that may be issued in the event the  Company  achieves
            certain  milestones in the development of C225, our lead therapeutic
            product pursuant to the terms of a Development and License Agreement
            entered into with Merck KGaA in December 1998. Under this agreement,
            Merck KGaA is paying to the Company, among other things, $30 million
            assuming the Company  achieves  certain  milestones  for which Merck
            KGaA will receive equity (the  "Milestone  Shares") in ImClone which
            will be priced at varying  premiums to the then market  price of the
            common stock  depending  upon the timing of the  achievement  of the
            respective milestones.  Because the exact number of shares needed to
            be  reserved  cannot be  determined  due to the  fluctuating  market
            price,  the Company has currently  reserved a number of shares based
            upon the market price at April 1, 1999. A different number of shares
            could be required based on  fluctuations  in the price of the common
            stock.

   
      Accordingly,  giving effect to such issuances and reserves,  approximately
8,393,861  shares of common  stock  would  remain  available  for  issuance.  If
Proposal  Nos. 2, 3, 5 and 6 described in this proxy  statement  are approved by
shareholders  at the  meeting,  approximately  5,743,861  shares of common stock
would remain available for issuance.
    

      The Board of Directors  believes  that it is in the best  interests of the
Company  to  increase  the  authorized  number of shares  of common  stock  from
45,000,000 to 60,000,000,  and on March 29, 1999 the Board voted  unanimously to
submit to a vote of  stockholders  an amendment to the Company's  certificate of
incorporation  so increasing  the  authorized  common stock.  The Company has no
present  agreement,  commitment,  plan or intent to issue any of the  additional
shares of common  stock  provided for in this  Proposal  other than as discussed
above. If this Proposal is approved,  the additional authorized common stock, as
well as the currently authorized but unissued common stock (but for those shares
which are  reserved),  would be  immediately  available  in the  future for such
corporate  purposes  as the Board  deems  advisable  from  time to time  without
further action by the stockholders, unless such action is required by applicable
law or any stock exchange or securities  market upon which the Company's  shares
may be listed.


                                       27
<PAGE>

      The additional authorized common stock resulting from the approval of
this Proposal will have the same terms and rights as the existing  common stock.
Holders of the common  stock of the  Company do not  presently  have  preemptive
rights nor will they as a result of the approval of this Proposal.

   
      The Board  anticipates that the authorized common stock in excess of those
shares  issued  and  reserved  for  issuance  (including,  if  authorized,   the
additional  common  stock  provided for in this  Proposal)  will be utilized for
general corporate purposes,  including grants of stock options. These shares may
also be publicly sold or privately placed as part of financing  transactions and
may be utilized  by the  Company in  connection  with  acquisitions,  commercial
agreements and stock splits.  Such increase in shares also could be used to make
more  difficult  a change in control of the  Company.  Though the Company has no
current  plan or  intention  to issue  such  shares as a takeover  defense,  the
additional authorized shares could be used to discourage persons from attempting
to gain control of the Company or make more difficult the removal of management.
Management is not currently  aware of any specific  effort to obtain  control of
the Company by means of a merger,  tender offer,  solicitation  in opposition to
management, or otherwise.
    

      It should be noted that,  subject to the limitations  discussed above, all
of the types of Board action described in the preceding paragraphs can currently
be taken and the power of the Board to take such  actions  would not be enhanced
by the passage of this  Proposal,  although  this  Proposal  would  increase the
number of shares of common stock that are subject to such action.

      If this  Proposal is approved  and the  amendment  to the  certificate  of
incorporation  becomes  effective,  the first paragraph of Article Fourth of the
certificate  of  incorporation,   which  sets  forth  the  Company's   presently
authorized capital stock, will be amended to read as set forth below.

         "FOURTH:  The  total  number  of  shares  of  capital  stock  which the
         Corporation  shall  have  the  authority  to  issue  is  sixty  million
         (60,000,000)  shares of common  stock  with a par value of one tenth of
         one cent  ($.001)  per share  and four  million  (4,000,000)  shares of
         preferred stock with a par value of one dollar ($1.00) per share."

      The  Board  recommends  a vote  "FOR"  approval  of the  amendment  to the
Company's   certificate  of  incorporation  to  increase  the  total  number  of
authorized shares of common stock from 45,000,000 to 60,000,000  (Proposal No. 4
on your proxy card).


                                       28
<PAGE>

                                 PROPOSAL NO. 5

     APPROVAL OF GRANT BY THE BOARD OF DIRECTORS TO THE PRESIDENT AND CHIEF
             EXECUTIVE OFFICER OF AN OPTION TO PURCHASE COMMON STOCK
                                  

      The Compensation Committee granted, subject to Board approval, shareholder
approval and a favorable  opinion from an  unaffiliated  executive  compensation
consulting  firm,  an  option  to Dr.  Samuel  D.  Waksal,  President  and Chief
Executive  Officer,  for the purchase of 1,000,000  shares of common stock.  The
Board approved the grant,  subject to shareholder  approval,  on March 29, 1999.
The Compensation  Committee and the Board have received a favorable opinion from
an unaffiliated executive compensation  consulting firm as to the reasonableness
of the grant.  The  Compensation  Committee  and the Board  determined  that the
exercise  price at which such shares could be  purchased  pursuant to the option
should be equal to the last  reported sale price of the common stock on the date
of grant, which assuming shareholder approval of the grant, will be May 24, 1999
which is the date of the  meeting.  The last  reported  sale price of the common
stock as  reported  by the Nasdaq  National  Market on the date of  Compensation
Committee  approval,  Board approval and April 1, 1999 as reported by Nasdaq was
$13 1/4, $15 1/8 and $16 1/2, respectively.

      In  evaluating  the   reasonableness  of  this  grant  the  following  was
considered:

      o     The critical  importance  of Dr.  Samuel D. Waksal to the  Company's
            ongoing research and development initiatives.
      o     The difficulty of replacing this individual.
      o     The objective of providing  strong incentive to Dr. Samuel D. Waksal
            consistent with enhancing shareholder value.
      o     The vesting requirements placed on this grant.
      o     The multi-year nature of the award,  which essentially  serves as an
            acceleration  of grants that might  otherwise be made in the future,
            it being the intent of the Board that there be no additional  option
            grants to Dr. Samuel D. Waksal until 2003 at the earliest.

   
      o     The  reasonable  size of the award  compared to the Company's  total
            shares outstanding, both on a primary and fully-diluted basis.
    

      Following is a description of the option, including certain federal income
      tax consequences.

Description of Option and New Plan Benefits

      The option will not be granted to Dr.  Samuel D.  Waksal  unless and until
shareholder  approval is obtained at the meeting on May 24,  1999.  The exercise
price will be the last  reported sale price of the common stock on May 24, 1999.
The option will vest in its entirety on May 24, 2006; except that the option may
vest earlier as follows:

- --------------------------------------------------------------------------------
 Number of Shares         Vesting Date        Target Price of Stock
- --------------------------------------------------------------------------------
        200,000           May 24, 2000      If for any ten  consecutive  trading
                                            days from May 24, 1999  through
                                            May 23,  2000  the  last  reported
                                            sale  price  of the  common  stock
                                            exceeds $25.
- --------------------------------------------------------------------------------
        200,000           May 24, 2001      If for any ten  consecutive  trading
                                            days from May 24, 2000  through
                                            May 23,  2001  the  last  reported
                                            sale  price  of the  common  stock
                                            exceeds $34.
- --------------------------------------------------------------------------------
        200,000           May 24, 2002      If for any ten  consecutive  trading
                                            days from May 24, 2001  through
                                            May 23,  2002  the  last  reported
                                            sale  price  of the  common  stock
                                            exceeds $47.
- --------------------------------------------------------------------------------
        200,000           May 24, 2003      If for any ten  consecutive  trading
                                            days from May 24, 2002  through
                                            May 23,  2003  the  last  reported
                                            sale  price  of the  common  stock
                                            exceeds $62.
- --------------------------------------------------------------------------------
        200,000           May 24, 2004      If for any ten  consecutive  trading
                                            days from May 24, 2003  through
                                            May 23,  2004  the  last  reported
                                            sale  price  of the  common  stock
                                            exceeds $75.
- --------------------------------------------------------------------------------
       1,000,000
- --------------------------------------------------------------------------------


                                       29
<PAGE>

   
      Additionally, the option will vest on any given vesting date for which the
applicable target price was achieved as to any shares as to which the option did
not vest on any prior  vesting  date as a result of the target  price not having
been achieved.  For example,  assume there are no ten  consecutive  trading days
during the period May 24, 1999 through May 23, 2000 that the last  reported sale
price of the common  stock  exceeds $25, and that during the period May 24, 2000
through May 23, 2001 there is a ten consecutive  trading day period during which
the last  reported  sale  price of the  common  stock  exceeds  $34.  Under this
scenario,  Dr. Samuel D.  Waksal's  option vests as to no shares on May 24, 2000
and as to 400,000 shares on May 24, 2001.

      The vesting of the option will  accelerate in the event of an  acquisition
of the  Company  where Dr.  Samuel D.  Waksal's  position  with the  Company  is
terminated.

      Once vested as to any shares,  the option may be  exercised in whole or in
part as to such  shares  from  time to time  until  May 24,  2009 so long as Dr.
Samuel D. Waksal remains employed by the Company.  Payment of the exercise price
of the option must be made in full in cash at the time of  exercise.  The option
will  provide  for  certain   adjustments  in  the  event  of  certain  mergers,
consolidations,  reorganizations,  recapitalizations, stock dividends, split-ups
continuations or similar events involving the Company or common stock.

    
      The option will otherwise contain usual and customary terms which shall be
substantially  the same as those  contained in the Company's 1996  Non-Qualified
Plan discussed under Proposal No. 3.
   

      It is the  intent  of the  Board  that  this  grant  provides  significant
retention  value and incentive  with respect to the continued  employment of Dr.
Samuel D.  Waksal  over the next four  years,  and that  there be no  additional
option grants to him until 2003 at the earliest.
    

      The Company does not anticipate any particular  events which would require
administration  of the option.  However,  all decisions of the Company regarding
the option are expected to be made by the Board or a duly  authorized  committee
of the Board.

      The option is not subject to any provision of ERISA.

      The common  stock which may be purchased by exercise of the option has not
been  registered  under the Securities Act of 1933, as amended (the  "Securities
Act") and  unless  the  Company  registers  the stock in the  future,  the stock
acquired  by exercise  of the option  will be  restricted  stock and will not be
freely  tradable.  The  Board  may at any  time  elect  to  file a  registration
statement  under the Securities  Act covering the stock,  which would permit the
holder of the option to sell the stock  freely  after  exercise.  It is expected
that such a registration statement will be filed in the future.

U.S. Federal Income Tax Consequences

      The  following is a summary of the U.S.  Federal  income tax  consequences
under  current tax law  (without  regard to any proposed  changes,  which may be
retroactive in effect) with respect to the  non-qualified  stock option proposed
to be granted to Dr. Samuel D. Waksal. For this purpose,  it is assumed that the
shares  acquired  pursuant  to the  exercise of the option are held as a capital
asset

      The option will not be qualified under Section 401(a) of the Code.

   
      No taxable  income  will be  recognized  by Dr.  Samuel D. Waksal upon the
grant of the option.  Upon the  exercise  of the option,  the excess of the fair
market value of the shares at the time of such exercise over the exercise  price
will be treated as compensation. Any amounts treated as compensation (i) will be
taxable as ordinary  income to Dr. Samuel D. Waksal and (ii)  generally  will be
allowed  as an income tax  deduction  to the  Company.  His tax basis for shares
acquired upon exercise of the option will be increased by any amounts so treated
as  compensation. 

      Any gain or loss realized on the subsequent  sale of shares  acquired upon
the  exercise  of the  option  will be  short-term  or  long-term  capital  gain
depending on the period the shares were held. 

      Consideration  received  upon the surrender  to, or  cancellation  by, the
Company of the option  will be taxable as ordinary  income to him and  generally
allowed as an income tax deduction to the Company.
    

      The Board  recommends  a vote "FOR"  approval of the grant of an option to
purchase  1,000,000 shares of common stock to the Company's  President and Chief
Executive Officer (Proposal No. 5 on your proxy card).


                                       30
<PAGE>

                                 PROPOSAL NO. 6

   APPROVAL OF GRANT BY THE BOARD OF DIRECTORS TO THE EXECUTIVE VICE PRESIDENT
       AND CHIEF OPERATING OFFICER OF AN OPTION TO PURCHASE COMMON STOCK

      The Compensation Committee granted, subject to Board approval, shareholder
approval and a favorable  opinion from an  unaffiliated  executive  compensation
consulting firm, an option to Dr. Harlan W. Waksal, Executive Vice President and
Chief Operating Officer, for the purchase of 650,000 shares of common stock. The
Board approved the grant,  subject to shareholder  approval,  on March 29, 1999.
The Compensation  Committee and the Board have received a favorable opinion from
an unaffiliated executive compensation  consulting firm as to the reasonableness
of the grant.  The  Compensation  Committee  and the Board  determined  that the
exercise  price at which such shares could be  purchased  pursuant to the option
should be equal to the last  reported sale price of the common stock on the date
of grant, which assuming shareholder approval of the grant, will be May 24, 1999
which is the date of the  meeting.  The last  reported  sale price of the common
stock as  reported  by the Nasdaq  National  Market on the date of  Compensation
Committee  approval,  Board approval and April 1, 1999 as reported by Nasdaq was
$13 1/4, $15 1/8 and $16 1/2, respectively.

      In  evaluating  the   reasonableness  of  this  grant  the  following  was
considered:

   
      o     The critical  importance  of Dr.  Harlan W. Waksal to the  Company's
            ongoing research and development initiatives.
    

      o     The difficulty of replacing this individual.

   
      o     The objective of providing  strong incentive to Dr. Harlan W. Waksal
            consistent with enhancing shareholder value.
    

      o     The vesting requirements placed on this grant.

   
      o     The multi-year nature of the award,  which essentially  serves as an
            acceleration  of grants that might  otherwise be made in the future,
            it being the intent of the Board that there be no additional  option
            grants to Dr. Harlan W. Waksal until 2003 at the earliest.

      o     The  reasonable  size of the award  compared to the Company's  total
            shares outstanding, both on a primary and fully-diluted basis.
    

      Following is a description of the option, including certain federal income
      tax consequences.

Description of Option and New Plan Benefits

   
      The option will not be granted to Dr.  Harlan W.  Waksal  unless and until
shareholder  approval is obtained at the meeting on May 24,  1999.  The exercise
price will be the last  reported sale price of the common stock on May 24, 1999.
The option will vest in its entirety on May 24, 2006; except that the option may
vest earlier as follows:
    

- --------------------------------------------------------------------------------
Number of Shares        Vesting Date        Target Price of Stock
        130,000         May 24, 2000        If for any ten  consecutive  trading
                                            days from May 24, 1999 through
                                            May 23,  2000 the  last  reported
                                            sale  price of the  common  stock
                                            exceeds $25.
- --------------------------------------------------------------------------------
        130,000         May 24, 2001        If for any ten  consecutive  trading
                                            days from May 24, 2000 through
                                            May 23,  2001 the  last  reported
                                            sale  price of the  common  stock
                                            exceeds $34.
- --------------------------------------------------------------------------------
        130,000         May 24, 2002        If for any ten  consecutive  trading
                                            days from May 24, 2001 through
                                            May 23,  2002 the  last  reported
                                            sale  price of the  common  stock
                                            exceeds $47.
- --------------------------------------------------------------------------------
        130,000         May 24, 2003        If for any ten  consecutive  trading
                                            days from May 24, 2002 through
                                            May 23,  2003 the  last  reported
                                            sale  price of the  common  stock
                                            exceeds $62.
- --------------------------------------------------------------------------------
        130,000         May 24, 2004        If for any ten  consecutive  trading
                                            days from May 24, 2003 through
                                            May 23,  2004 the  last  reported
                                            sale  price of the  common  stock
                                            exceeds $75.
- --------------------------------------------------------------------------------
        650,000
- --------------------------------------------------------------------------------


                                       31
<PAGE>

   
      Additionally, the option will vest on any given vesting date for which the
applicable target price was achieved as to any shares as to which the option did
not vest on any prior  vesting  date as a result of the target  price not having
been achieved.  For example,  assume there are no ten  consecutive  trading days
during the period May 24, 1999 through May 23, 2000 that the last  reported sale
price of the common  stock  exceeds $25, and that during the period May 24, 2000
through May 23, 2001 there is a ten consecutive  trading day period during which
the last  reported  sale  price of the  common  stock  exceeds  $34.  Under this
scenario,  Dr. Harlan W.  Waksal's  option vests as to no shares on May 24, 2000
and as to 260,000 shares on May 24, 2001.

      The vesting of the option will  accelerate in the event of an  acquisition
of the  Company  where Dr.  Harlan W.  Waksal's  position  with the  Company  is
terminated.

      Once vested as to any shares,  the option may be  exercised in whole or in
part as to such  shares  from  time to time  until  May 24,  2009 so long as Dr.
Harlan W. Waksal remains employed by the Company.  Payment of the exercise price
of the option must be made in full in cash at the time of  exercise.  The option
will  provide  for  certain   adjustments  in  the  event  of  certain  mergers,
consolidations,  reorganizations,  recapitalizations, stock dividends, split-ups
continuations or similar events involving the Company or common stock.
    

      The option will otherwise contain usual and customary terms which shall be
substantially  the same as those  contained in the Company's 1996  Non-Qualified
Plan discussed under Proposal No. 3.

   
      It is the  intent  of the  Board  that  this  grant  provides  significant
retention  value and incentive  with respect to the continued  employment of Dr.
Harlan W.  Waksal  over the next four  years,  and that  there be no  additional
option grants to him until 2003 at the earliest.
    

      The Company does not anticipate any particular  events which would require
administration  of the option.  However,  all decisions of the Company regarding
the option are expected to be made by the Board or a duly  authorized  committee
of the Board.

      The option is not subject to any provision of ERISA.

      The common  stock which may be purchased by exercise of the option has not
been  registered  under the Securities Act and unless the Company  registers the
stock in the  future,  the stock  acquired  by  exercise  of the option  will be
restricted  stock  and will not be  freely  tradable.  The Board may at any time
elect to file a  registration  statement  under the  Securities Act covering the
stock,  which  would  permit the  holder of the option to sell the stock  freely
after exercise. It is expected that such a registration  statement will be filed
in the future.

U.S. Federal Income Tax Consequences

   
      The  following is a summary of the U.S.  Federal  income tax  consequences
under  current tax law  (without  regard to any proposed  changes,  which may be
retroactive in effect) with respect to the  non-qualified  stock option proposed
to be granted to Dr. Harlan W. Waksal. For this purpose,  it is assumed that the
shares  acquired  pursuant  to the  exercise of the option are held as a capital
asset.

      The option will not be qualified under Section 401(a) of the Code.

      No taxable  income  will be  recognized  by Dr.  Harlan W. Waksal upon the
grant of the option.  Upon the  exercise  of the option,  the excess of the fair
market value of the shares at the time of such exercise over the exercise  price
will be treated as compensation. Any amounts treated as compensation (i) will be
taxable as ordinary  income to Dr. Harlan W. Waksal and (ii)  generally  will be
allowed  as an income tax  deduction  to the  Company.  His tax basis for shares
acquired upon exercise of the option will be increased by any amounts so treated
as  compensation. 

      Any gain or loss realized on the subsequent  sale of shares  acquired upon
the  exercise  of the  option  will be  short-term  or  long-term  capital  gain
depending on the period the shares were held.

      Consideration  received  upon the surrender  to, or  cancellation  by, the
Company of the option  will be taxable as ordinary  income to him and  generally
allowed as an income tax deduction to the Company.
    

      The Board  recommends a vote "FOR"  approval of the grant of the option to
purchase  650,000  shares  of  common  stock  to the  Company's  Executive  Vice
President  and Chief  Operating  Officer  (Proposal  No. 6 on your proxy  card).


                                       32
<PAGE>

                                 PROPOSAL NO. 7

            RATIFICATION OF INDEPENDENT CERTIFIED PUBLIC ACCOUNTANTS

   
      The  Board  has  selected  KPMG  LLP  as  independent   certified   public
accountants  for the Company for the year ending December 31, 1999. KPMG LLP has
served as the Company's auditor since 1988. The ratification of the selection of
independent certified public accountants is to be voted upon at the meeting, and
it is intended  that the persons named in the  accompanying  proxy will vote for
KPMG LLP.  Representatives  of KPMG LLP are expected to attend the  meeting,  to
have an  opportunity  to make a  statement  if  they  desire  to do so and to be
available to respond to appropriate questions.
    

      The Board  recommends a vote "FOR" the  ratification  of the  selection of
KPMG  LLP to act as the  Company's  certified  public  accountants  for the year
ending December 31, 1999 (Proposal No. 7 on your proxy card).

STOCKHOLDERS' PROPOSALS

      A stockholder  proposal  intended to be presented at the Company's  Annual
Meeting of Stockholders to be held in 2000 must be received by the Company on or
before  December  25,  1999 in  order  to be  included  in the  Company's  proxy
statement and form of proxy relating to that meeting.

      Please complete, sign and date the enclosed proxy card, which is revocable
as described herein, and mail it promptly in the enclosed postage-paid envelope.

                                              By Order of the Board of Directors

   
                                              /s/ John B. Landes
    
                                              John B. Landes
                                              Secretary
New York, New York

   
April 21, 1999
    

      IT IS IMPORTANT THAT PROXIES BE RETURNED PROMPTLY. WE URGE YOU TO FILL IN,
SIGN AND RETURN THE  ACCOMPANYING  PROXY CARD, NO MATTER HOW LARGE OR SMALL YOUR
HOLDINGS MAY BE.


                                       33
<PAGE>

   
                                                                      Appendix A
    

                          IMCLONE SYSTEMS INCORPORATED

Dear Stockholder:

Please take note of the important  information  enclosed with this Proxy Ballot.
There are a number of issues  related to the  management  and  operation of your
Company that require your immediate attention and approval.  These are discussed
in detail in the enclosed proxy materials.

Your vote counts, and you are strongly encouraged to exercise your right to vote
your shares.

Please  mark the boxes on this proxy card to indicate  how your shares  shall be
voted,  then sign the card, detach it and return your proxy vote in the enclosed
postage paid envelope.

Your vote must be received prior to the Annual Meeting of Shareholders,  May 24,
1999.

Thank you in advance for your prompt consideration of these matters.

Sincerely,
ImClone Systems Incorporated

<PAGE>

     PLEASE MARK VOTES AS IN
 X   THIS EXAMPLE
- ---

ImClone Systems Incorporated

Mark box at right if an address change or comment has been noted on the reverse
side of this card. ______

RECORD DATE SHARES:

1)  ELECTION OF DIRECTORS. For:  _____  Withhold:  _____  For All Except: _____

Nominees:

Richard Barth
Jean Carvais
Vincent T. DeVita, Jr.
Robert F. Goldhammer
David M. Kies
Paul B. Kopperl
John Mendelsohn
William R. Miller
Harlan W. Waksal
Samuel D. Waksal

NOTE: If you do not wish your shares voted "For" a particular nominee,  mark the
"For All  Except" box and strike a line  through the name(s) of the  nominee(s).
Your shares shall be voted for the remaining nominee(s).

2)    To approve an amendment to the Company's 1996 Incentive Stock Option Plan,
      as amended  (the "1996 ISO Plan") to increase  the number of shares of the
      Company's  common stock which may be issued  pursuant to options which may
      be granted  under the 1996 ISO Plan from  3,000,000  to  4,000,000,  which
      number shall be reduced by the number of shares of common stock which have
      been or may be issued pursuant to options granted under the Company's 1996
      Non-Qualified  Stock  Option  Plan,  as amended  (the "1996  Non-Qualified
      Plan").

         For: _____                 Against: _____            Abstain: _____

3)    To approve  amendments to the 1996  Non-Qualified Plan to (i) increase the
      number  of  shares  of the  Company's  common  stock  which  may be issued
      pursuant to options which may be granted under the 1996 Non-Qualified Plan
      from  3,000,000 to 4,000,000,  which number shall be reduced by the number
      of shares of common  stock  which have been or may be issued  pursuant  to
      options  granted  under the 1996 ISO Plan,  and (ii)  increase  the annual
      option grant made to  non-employee  members of the Board of Directors  and
      the non-employee  Chairman under the 1996 Non-Qualified Plan from 2,500 to
      15,000 and from 2,500 to 30,000, respectively.

         For: _____                 Against: _____            Abstain: _____

4)    To approve an amendment to the Company's  certificate of  incorporation to
      increase the number of shares of common stock the Company is authorized to
      issue from 45,000,000 to 60,000,000.

         For: _____                 Against: _____            Abstain: _____

   
5)    To approve  the grant of an option to the  President  and Chief  Executive
      Officer to purchase 1,000,000 shares of the Company's common stock.
    

         For: _____                 Against: _____            Abstain: _____

   
6)    To approve  the grant of an option to the  Executive  Vice  President  and
      Chief Operating Officer to purchase 650,000 shares of the Company's common
      stock.
    

         For: _____                 Against: _____            Abstain: _____


<PAGE>

7)    To  ratify  the  appointment  of  KPMG  LLP  to  serve  as  the  Company's
      independent  certified  public  accountants  for the  fiscal  year  ending
      December 31, 1999.

         For: _____                 Against: _____            Abstain: _____

8)    To consider and act upon any other business as may come before the meeting
      or any adjournment thereof.


Please be sure to sign and date this Proxy.          Date:

- --------------------------------------------------------------
Stockholder sign here                       Co-owner sign here

                          IMCLONE SYSTEMS INCORPORATED

               Proxy for the Meeting of Stockholders, May 24, 1999
           This Proxy is Solicited on Behalf of the Board of Directors

   
The undersigned hereby appoints Robert F. Goldhammer,  John B. Landes and Samuel
D. Waksal as Proxies each with power of substitution and hereby  authorizes each
of them to represent and to vote, as designated  below, all the shares of Common
Stock of ImClone Systems Incorporated held of record by the undersigned on April
7, 1999 at the Annual  Meeting of  Stockholders  to be held at 10:00 a.m. on May
24, 1999 or any adjournment thereof.

PLEASE MARK, SIGN, DATE AND RETURN THIS PROXY TO STATE STREET BANK AND TRUST
COMPANY. THE COMPANY'S TRANSFER AGENT, TO BE RECEIVED NO LATER THAN MAY 23,
1999.
    

This Proxy when properly executed will be voted in the manner directed herein by
the undersigned stockholder. IF NO DIRECTION IS MADE, THIS PROXY WILL BE VOTED
FOR PROPOSALS 1, 2, 3, 4, 5, 6 AND 7.

PLEASE  VOTE,  DATE AND SIGN ON REVERSE  AND  RETURN  PROMPTLY  IN THE  ENCLOSED
ENVELOPE

NOTE:  Please sign  exactly as your name(s)  appear(s)  on this card.  All joint
owners should sign. When signing as executor,  administrator,  attorney, trustee
or guardian or as custodian  for a minor,  please give full title as such.  If a
corporation,  please  sign in full  corporate  name and  indicate  the  signer's
office. If a partner, sign the partnership name.

HAS YOUR ADDRESS CHANGED?                 DO YOU HAVE ANY COMMENTS?

________________________________          ___________________________________

________________________________          ___________________________________

________________________________          ___________________________________



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