ISCO INC
S-3, 1997-11-26
INDUSTRIAL INSTRUMENTS FOR MEASUREMENT, DISPLAY, AND CONTROL
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<PAGE>

                   UNITED STATES SECURITIES AND EXCHANGE COMMISSION
                                WASHINGTON, D.C. 20549

                                ----------------------

                                       FORM S-3

                                REGISTRATION STATEMENT

                                        UNDER

                              THE SECURITIES ACT OF 1933

                                ----------------------

                                      ISCO, INC.
                (Exact name of registrant as specified in its charter)

            NEBRASKA                                    47-0461807
  (State or other jurisdiction               (I.R.S. Employer Identification
of incorporation of organization)                         Number)

                    4700 SUPERIOR STREET, LINCOLN, NE.  68504-1398
                                    (402) 464-0231
             (Address, including zip code and telephone number, including
               area code, of registrant's principal executive offices)

                                  STEPHEN E. GEHRING
                            1125 S. 103RD STREET, STE. 720
                                  OMAHA, NE.  68124
                                    (402) 397-1700
              (Name, address, including zip code, and telephone number,
                      including area code of agent for service)

                                ----------------------

           APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE TO THE PUBLIC:
               AS SOON AS PRACTICABLE AFTER THE EFFECTIVE DATE HEREOF.

                                ----------------------

    If any of the securities being registered on this Form are to be offered 
on a delayed or continuous basis pursuant to Rule 415 under the Securities 
Act of 1933, other than securities offered only in connection with dividend 
or interest reinvestment plans, check the following box: /X/

    If the only securities being registered on this Form are being offered 
pursuant to dividend or interest reinvestment plans, please check the 
following box: / /

    If this Form is filed to register additional securities for an offering 
pursuant to Rule 462(b) under the Securities Act, please check the following 
box and list the Securities Act registration statement number of the earlier 
effective registration statement for the same offering. / /

    If this Form is a post-effective amendment filed pursuant to Rule 462(c) 
under the Securities Act, check the following box and list the Securities Act 
registration statement number of the earlier effective registration statement 
for the same offering. / /

    If delivery of the prospectus is expected to be made pursuant to Rule 
434, please check the following box:   / /

<PAGE>

                        CALCULATION OF REGISTRATION FEE

<TABLE>
<CAPTION>
                                                   PROPOSED MAXIMUM        PROPOSED MINIMUM
   TITLE OF EACH CLASS OF         AMOUNT TO         OFFERING PRICE            AGGREGATE               AMOUNT OF
SECURITIES TO BE REGISTERED     BE REGISTERED          PER UNIT             OFFERING PRICE         REGISTRATION FEE
<S>                             <C>                <C>                     <C>                     <C>
COMMON STOCK                       318,853              $9.25(1)             $2,643,291.37             $893.75
</TABLE>


(1) Estimated pursuant to Rule 457 of the Securities Act of 1933, as amended 
    (the "Act") solely for the purpose of calculating the registration fee. 
    The price is based upon the last reported sale price on NASDAQ-NMS within 
    five business days prior to filing.


    THE REGISTRANT HEREBY AMENDS THIS REGISTRATION STATEMENT ON SUCH DATE OR 
DATES AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANT 
SHALL FILE A FURTHER AMENDMENT WHICH SPECIFICALLY STATES THAT THIS 
REGISTRATION STATEMENT SHALL BECOME EFFECTIVE IN ACCORDANCE WITH SECTION 8(A) 
OF THE SECURITIES ACT OF 1933 OR UNTIL THE REGISTRATION STATEMENT SHALL 
BECOME EFFECTIVE ON SUCH DATE OR DATES AS THE COMMISSION, ACTING PURSUANT TO 
SAID SECTION 8(A) MAY DETERMINE.
<PAGE>

PROSPECTUS

                                  ISCO, INC.


    This Prospectus relates to the offering by ten shareholders (collectively 
"Selling Shareholders") of 318,853 shares of common stock of Isco, Inc. (the 
"Company"), par value $.10 (the "Common Stock").  The names of the Selling 
Shareholders, and the respective number of shares owned by each of them, are 
set forth below in the section entitled "Selling Shareholders."  The Selling 
Shareholders  each acquired their respective shares of Common Stock in 
connection with an Agreement and Plan of Merger, dated as of September 8, 
1997, among Isco, Inc., Isco Acquisition Corp., a Nebraska corporation, and 
Geomation, Inc., a Colorado corporation.  The 318,853 shares of Common Stock 
being registered formed part of the consideration for the merger and are 
fully paid and non-assessable.

    The Common Stock of the Company is listed on the NASDAQ-NMS under the 
symbol "ISKO".   On November 21, 1997, the last reported sale price of the 
Common Stock as quoted on NASDAQ-NMS was $9.25 per share.

    The Company will not receive any of the proceeds from the sale of the 
shares of Common Stock being registered by the Selling Shareholders.  

    All expenses of the registration of securities covered by this 
Prospectus, estimated to be approximately $9,893.75, are to be borne by the 
Company.

    THE SECURITIES OFFERED HEREBY ARE SPECULATIVE AND INVOLVE A HIGH DEGREE 
OF RISK. SEE "RISK FACTORS", BEGINNING ON PAGE 3 OF THIS PROSPECTUS.

   THESE SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE SECURITIES
    AND EXCHANGE COMMISSION OR ANY STATE SECURITIES COMMISSION NOR HAS THE
          SECURITIES AND EXCHANGE COMMISSION OR ANY STATE SECURITIES
               COMMISSION PASSED UPON THE ACCURACY OR ADEQUACY
                  OF THIS PROSPECTUS.  ANY REPRESENTATION TO
                     THE CONTRARY IS A CRIMINAL OFFENSE.

              The date of this Prospectus is November 24, 1997.

<PAGE>


                                AVAILABLE INFORMATION

    The Company is subject to the information requirements of the Securities 
Exchange Act of 1934, as amended (the "Exchange Act") and in accordance 
therewith, files reports and other information with the Securities and 
Exchange Commission (the "Commission").  Proxy statements, reports and other 
information concerning the Company can be inspected and copied at Room 1024 
of the Commission's office at 450 Fifth Street, N.W., Washington, D.C. 20549, 
and the Commission's Regional Offices in New York (Room 1228, 75 Park Place, 
New York, New York 10007), and Chicago (Suite 1400, Northwestern Atrium 
Center, 500 West Madison Street, Chicago, Illinois 60621-2511), and copies of 
such material can be obtained from the Public Reference Section of the 
Commission at 450 Fifth Street, N.W., Washington, D.C. 20549, at prescribed 
rates.  The Commission maintains a Web site that contains reports, proxy and 
information statements and other materials that are filed through the 
Commission's Electronic Data Gathering Analysis and Retrieval (EDGAR) System. 
This Web site can be accessed at http:\\www.sec.gov. This Prospectus does 
not contain all information set forth in the Registration Statement of which 
this Prospectus forms a part and exhibits thereto which the Company has filed 
with the Commission under the Securities Act of 1933, as amended (the 
"Securities Act") and to which reference is hereby made.

                         DOCUMENTS INCORPORATED BY REFERENCE

    The Company has provided, without charge, to each Selling Shareholder,  a 
copy of the Company's Annual Report on Form 10-K for the fiscal year ended 
July 25, 1997.  The Company will also provide, without charge, to each person 
to whom a copy of this Prospectus is delivered, upon the written or oral 
request of such person, a copy of any or all of the other documents 
incorporated by reference herein (other than exhibits to such documents, 
unless such exhibits are specifically incorporated by reference into the 
information that the  Prospectus incorporates).  Requests should be directed 
to:

                   Isco, Inc.
                   4700 Superior Street
                   Lincoln, Nebraska  68504-1398 
                   Attention: Philip M. Wittig, Chief Financial Officer
                   Phone: (402) 464-0231

    The following documents filed with the Commission by the Company are 
hereby incorporated by reference into this Prospectus:

    (1)  The Company's Annual Report on Form 10-K for the fiscal year ended
         July 25, 1997;

    (2)  Articles of Incorporation, as amended (incorporated by reference to
         Exhibit 3.1 to the Registration Statement on Form S-1 
         (File No. 2-99303)).

    All documents filed with the Commission by the Company pursuant to 
Sections 13(a), 13(c), 14, or 15(d) of the Exchange Act subsequent to the 
date of this Prospectus and prior to the termination of the offering 
registered hereby shall be deemed to be incorporated by reference into this  
Prospectus and to be a part hereof from the date of the filing of such 
documents.  Any statement contained in a document incorporated or deemed to 
be incorporated by reference herein shall be deemed to be modified or 
superseded for purposes of this  Prospectus to the extent that a statement 
contained herein or in any subsequently filed document which also is or is 
deemed to be incorporated by reference herein modifies or supersedes such 
statement.  Such statement so modified or superseded shall not be deemed, 
except as so modified or superseded, to constitute a part of this  
Prospectus.

                                       2
<PAGE>

                                  RISK FACTORS

    IN ADDITION TO THE OTHER INFORMATION IN THIS  PROSPECTUS, THE FOLLOWING 
RISK FACTORS SHOULD BE CONSIDERED CAREFULLY IN EVALUATING AN INVESTMENT IN 
THE COMPANY BEFORE PURCHASING THE SHARES OF COMMON STOCK OFFERED HEREBY.

    THIS PROSPECTUS CONTAINS TREND ANALYSIS AND OTHER FORWARD-LOOKING 
STATEMENTS WITHIN THE MEANING OF SECTION 27A OF THE SECURITIES ACT, AND 
SECTION 21E OF THE EXCHANGE ACT.  ACTUAL RESULTS COULD DIFFER MATERIALLY FROM 
THOSE PROJECTED IN THE FORWARD-LOOKING STATEMENTS THROUGHOUT THIS DOCUMENT.

COMPETITION

    Several competitors manufacture products similar to those of the Company, 
both domestically and internationally.   However, market information 
developed from internal and external sources indicates that the Company holds 
a significant share of the market.  Specifically, the Company estimates that 
it has 50 percent of the domestic wastewater sampler market, approximately 
20 to 25 percent of the domestic market for open channel flow meters (with 
each of the two major competitors holding a similar percent), and a share of 
the domestic liquid chromatography market comparable to that of its largest 
competitor. Generally, the Company has smaller market shares in the 
international market.

    During fiscal year 1997, the Company acquired substantially all of the 
assets and assumed selected liabilities of Suprex Corporation, Pittsburgh, 
Pennsylvania, a significant producer of supercritical fluid extractions 
("SFE") products.  The consolidated Isco/Suprex product line positioned the 
Company as the SFE equipment market leader with approximately 40 percent 
market share.

    No assurance can be given that the Company will not encounter new 
competitors, or that the equipment manufactured by the Company will not 
become obsolete as technology advances.   

    As in many industries, consolidation of companies within the Company's 
market is an on-going trend.  As a result, the Company is dealing with the 
effects of larger and well financed competitors some of which may have 
significantly greater financial resources than the Company, which could 
impede the Company's ability to compete effectively in the global market.

UNCERTAINTIES REGARDING INTERNATIONAL SALES

    The Company's international sales constituted 26, 27, and 22 percent of 
the Company's sales during fiscal 1997, 1996,  and 1995, respectively.  The 
Company expects that international sales will continue to account for a 
substantial portion of its revenues.  International sales may be subject to 
political and economic risks, including political instability, currency 
controls, fluctuating exchange rates with respect to sales not denominated in 
U.S. dollars,  and changes in import/export regulations, tariffs and freight 
rates.  To date, all of the Company's international sales have been 
denominated in U.S. dollars.  A weakening in the value of foreign currencies 
relative to the U.S. dollar could have an adverse impact on the Company by 
increasing the effective price of the Company's products in its international 
markets.  In addition, there can be no assurance that the Company's 
international customers will continue to accept orders denominated in U.S. 
dollars.  To the extent that orders are denominated in foreign currencies, 
the Company's reported sales and earnings are more directly subject to 
foreign exchange fluctuation.  There can be no assurance that these factors 
will not adversely affect the Company's international sales in the future.

REGULATION

    Management believes it is in compliance with environmental regulations. 
Therefore, no unfavorable impact on competition or earnings is expected. 
Although the Company's products are not

                                       3
<PAGE>

subject to significant U.S. government regulation,  approximately 65 percent 
of the Company's sales are to the environmental market.  This is a regulation 
driven market which is strongly influenced by both the perceived attitude and 
actions of the various governmental agencies in the promulgation and the 
enforcement of environmental regulations.  The effects of the regulatory 
climate on the market are outside the Company's ability to control and, for 
any given period, may be either a positive or negative factor on the 
Company's performance.  

RECENT DEVELOPMENTS

    On September 17, 1997, the Company acquired the remaining equity of 
Geomation, Inc.,  Golden, Colorado.  Geomation designs, manufacturers, and 
markets measurement and control systems for the geotechnical and 
environmental markets.  More than 70 percent of its sales are in dam 
monitoring applications. Geomation will continue its operations in Golden, 
Colorado as a subsidiary of Isco.   The acquisition required approximately 
$929,000 in cash and the issuance of 318,853 shares of the Company's Common 
Stock.  The transaction also included an earn-out provision, which, depending 
upon the performance of Geomation through July 1998 may require the payment 
of up to $250,000 of  additional cash and the issuance of additional shares 
of the Company's Common Stock with a market value of up to approximately 
$750,000.  This transaction is being treated as a purchase.  Depending upon 
the performance of Geomation and the amortization of intangibles resulting 
from the acquisition, management expects the Company will experience some 
dilution of earnings during the next several years.

UNCERTAINTY OF FUTURE ACQUISITIONS

    The Company continues to actively pursue the acquisition of companies and 
product lines which will compliment its existing product lines.  The recent 
acquisition of Geomation, Inc. provides the Company with access to field data 
collection and transmission technology and expertise.  It is management's 
expectation that this technology can be adapted to meet the needs of the 
Company's sampler and flow meter customers.  Management expects the 
adaptation to be completed in fiscal 1999.

    Significant uncertainties accompany any acquisition and its integration 
with the Company's existing operations, such that any acquisition could have 
an adverse effect on the Company.  There can be no assurance that the Company 
will be able to locate appropriate acquisition candidates, that any 
identified candidates will be acquired, or that acquired operations will be 
effectively integrated or prove profitable.

FACTORS AFFECTING FUTURE RESULTS

    Factors which management believes may affect the future financial 
performance of the Company include but are not limited to: the successful 
implementation of manufacturing and business processes which will reduce 
costs and improve efficiency; the investment in engineering and marketing 
activities which lead to improved sales growth; the successful integration of 
acquisitions into the Company's operations; dealing with the external 
regulatory influences on the Company's primary markets; and the effect on the 
competitive environment resulting in the consolidation of companies within 
the instrumentation industry.

    During fiscal 1997, the Company invested in initiatives which, when fully 
implemented, are expected to improve the effectiveness and efficiency of its 
business and manufacturing processes.  The investment in these initiatives 
will continue during fiscal 1998, with the benefits of successful 
implementation to be realized fully in the fiscal years beginning in fiscal 
1999.

    The Company will continue to invest approximately 10 percent of sales in
product development.  Management will direct these efforts to those projects
which it believes will contribute significantly to profitable sales growth. 
Management must also develop the marketing strategies which will focus 

                                       4
<PAGE>

energy and resources in those areas which will assist in growing sales 
profitability and thereby diluting the fixed cost structure of the Company.

DEPENDENCE ON KEY MANAGEMENT

    The Company's success depends, in substantial part, on the efforts and 
abilities of Douglas M. Grant, the Company's President and Chief Operating 
Officer. The Company has no employment agreement with Mr. Grant.   Failure to 
retain the services of Mr. Grant could have a material adverse effect on the 
Company.  The Company does not maintain key man life insurance on the life of 
Mr. Grant. 

POSSIBLE VOLATILITY OF STOCK PRICE; LIMITED TRADING VOLUME

    The trading price of the Common Stock may be volatile and could be 
subject to significant fluctuations in response to variations in the 
Company's quarterly operating results, general conditions in the industries 
in which the Company operates and other factors.  In addition, the stock 
market is subject to price and volume fluctuations affecting the market price 
for the stock of many companies generally, which fluctuations often are 
unrelated to operating performance.  Although the Common Stock is listed on 
the NASDAQ-NMS, daily trading volume of the Common Stock has generally been 
limited and accordingly the trading price is more vulnerable to significant 
fluctuations.

                                   USE OF PROCEEDS

    The Company is registering the Common Stock pursuant to demands from the 
Selling Shareholders.  The Company will not receive any of the proceeds from 
the sale of the shares of Common Stock being registered by the Selling 
Shareholders.

                                   DIVIDEND POLICY

    The declaration and payment of dividends by the Company are subject to 
the discretion of the Board.  Any determination by the Board as to the 
payment of dividends in the future will depend upon, among other things, 
business conditions and the Company's financial condition and capital 
requirements, as well as any other factors deemed relevant by the Board.  For 
nearly 50 quarters, the Company has paid a quarterly cash dividend.

                                       5
<PAGE>
                             SELLING SHAREHOLDERS


    The following table sets forth the beneficial ownership of Common Stock 
of the Company for the Selling Shareholders as of November 1, 1997.

<TABLE>
<CAPTION>

                         Amount of Beneficial                                                      Beneficial Ownership of
                          Ownership of Common                                                        Common Stock After
                            Stock Prior to                                                               Offering(2)
Name of Beneficial Owner       Offering                                                       --------------------------------
- ------------------------   ----------------       Percentage of           Number of Shares     Number         Percentage of
                           Number of Shares     Outstanding Shares(1)      to be Offered      of Shares     Outstanding Shares
                           ----------------     ------------------         -------------      ---------     ------------------
<S>                        <C>                  <C>                        <C>                <C>           <C>
John M. Klebba                  176,000                3.10%                  176,000              0                 0
David W. Benbow                  71,114                1.25%                   71,114              0                 0
Douglas E. Walliser              30,000                 .53%                   30,000              0                 0
Cletus A. Kolb                   13,000                 .23%                   13,000              0                 0
Kenneth L. Hultman                7,400                 .13%                    7,400              0                 0
Dennis E. Gunderson               7,400                 .13%                    7,400              0                 0
Garry G. Southard                 7,400                 .13%                    7,400              0                 0
Neal B. Gronlie                   3,739                 .07%                    3,739              0                 0
A. Geary Foulk                    1,800                 .03%                    1,800              0                 0
Carol H. Lucas                    1,000                 .02%                    1,000              0                 0
</TABLE>
(1) Based upon a total outstanding amount of 5,672,092 shares.

(2) Assuming the sale of all offered shares.

                                       6
<PAGE>
                                 PLAN OF DISTRIBUTION


    The Selling Shareholders, in the aggregate, are hereby offering for sale 
pursuant to this Prospectus, 318,853 shares of Common Stock, all of which 
were acquired in the course of the Isco-Geomation merger described in the 
first section of the Prospectus and in the section entitled "Recent 
Developments" under Risk Factors.  The Selling Shareholders may, under the 
Agreement and Plan of Merger with Geomation, receive additional shares of 
Isco Common Stock if Geomation achieves certain future financial results.  
Any such shares will be registered by amendment to this Prospectus.

    The distribution of shares of Common Stock by the Selling Shareholders 
may be offered in one of more transactions that may take place in ordinary 
broker transactions, privately negotiated transactions or through sales to 
one or more dealers for resale of such securities as principals, at market 
prices prevailing at the time of sale, at prices related to such prevailing 
market prices, or at negotiated prices.  Usual and customary or specifically 
negotiated brokerage fees or commissions may be paid by the Selling 
Shareholders in connection with such sales of securities.

    In order to comply with certain state securities laws, if applicable, the 
securities offered hereby will not be sold in a particular state unless such 
securities have been registered or qualified for sale in such state or an 
exemption from registration or qualification is available and complied with.

                             DESCRIPTION OF CAPITAL STOCK

    The total number of shares the Company is authorized to issue is 
20,000,000, consisting of 15,000,000 shares of Common Stock, par value 
$.10 per share, and 5,000,000 shares of Preferred Stock, par value 
$.10 per share. As of November 1, 1997, there were 5,672,092 shares of Common 
Stock outstanding and no shares of Preferred Stock outstanding.

COMMON STOCK

    Holders of Common Stock are entitled to one vote for each share held of 
record on all matters to be voted on by the shareholders.  Shareholders have 
cumulative voting rights with respect to the election of directors.  The 
holders of Common Stock are entitled to receive dividends, subject to the 
senior rights of preferred shareholders, when, as and if declared by the 
Board out of funds legally available therefor.  In the event of liquidation, 
dissolution or winding up of the Company, the holders of Common Stock are 
entitled to share ratably in all assets remaining which are available for 
distribution to them after payment of liabilities and after provision has 
been made for each class of stock having preference over the Common Stock.  
Holders of shares of Common Stock, as such, have no conversion, preemptive or 
other subscription rights, and there are no redemption provisions applicable 
to the Common Stock.  All of the outstanding shares of Common Stock are, and, 
upon completion of the offering, all shares of Common Stock offered hereby 
will be, duly authorized, fully paid and non-assessable.

PREFERRED STOCK

    The Board is authorized, without further approval or action by the 
shareholders, to issue shares of Preferred Stock in one or more series and to 
determine the rights, preferences, privileges and restrictions thereof, 
including dividend rights, conversion rights, voting rights, terms of 
redemption, liquidation preferences, sinking fund terms and number of shares 
constituting any series of Preferred Stock or the designation of such series.

                                       7
<PAGE>

    The rights of the holders of Common Stock will generally be subject to 
the prior rights of the holders of any outstanding shares of Preferred Stock 
with respect to dividends, liquidation preferences and other matters.  Among 
other things, the Preferred Stock could be issued by the Company to raise 
capital or finance acquisitions.  The Preferred Stock could have certain 
anti-takeover effects under certain circumstances.  The issuance of shares of 
Preferred Stock could enable the Board to render more difficult or discourage 
an attempt to obtain control of the Company by means of a merger, tender 
offer or other business combination transaction directed at the Company by, 
among other things, placing shares of Preferred Stock with investors who 
might align themselves with the Board, issuing new shares to dilute stock 
ownership of a person or entity seeking control of the Company or creating a 
class or series of Preferred Stock with class voting rights.

    The Company has no current plans to issue any shares of its Preferred 
Stock. 

CERTAIN PROVISIONS OF THE COMPANY'S ARTICLES OF INCORPORATION AND BY-LAWS

    CLASSIFIED BOARD OF DIRECTORS. The Company's Articles of Incorporation 
and By-Laws provide that the Board shall be divided into three classes of 
directors serving staggered terms.  One class of directors is elected at each 
annual meeting of shareholders for a three-year term.  Thus, at least two 
annual meetings of shareholders, instead of one, generally will be required 
to change the majority of the Board. Directors may only be removed by the 
shareholders at a meeting called for that purpose. Vacancies on the Board may 
be filled either by the remaining directors or by the shareholders. 

    NOMINATIONS TO THE BOARD OF DIRECTORS. The Company's By-Laws provide that 
the Board, as a whole, shall act as the Nominating Committee for selecting 
prospective nominees to serve as Directors.  The Board's recommended nominees 
are presented for nomination and election at a special or annual meeting of 
Shareholders.  Officers and individual Board members may recommend 
prospective Board nominees. Shareholders may submit matters for vote at any 
meeting of shareholders so long as the subject matter of the proposal 
complies with the Securities Exchange Act of 1934 and the rules thereunder.

    MEETINGS OF SHAREHOLDERS. The Company's Articles of Incorporation and 
By-Laws provide that special meetings of shareholders of the Company may be 
called by the President, by the Board of Directors, or by the holders of 
10 percent or more of the shares of voting stock then issued and outstanding.

    INDEMNIFICATION. The Company's By-Laws contain an extensive provision 
for indemnification of any person serving as a Director, officer, employee, 
or agent of the Company, for action taken in good faith and in a manner 
reasonably believed to be in or not opposed to the best interest of the 
Company.  The inclusion of the broad indemnification provision in the 
Company's By-Laws may have the effect of reducing the likelihood of 
derivative litigation against Directors and may discourage or deter 
shareholders or management from bringing a lawsuit against Directors for 
breach of their duty of care.

    AMENDMENT OR REPEAL OF BY-LAWS. The Company's By-Laws provide that the 
By-Laws may be amended or repealed at any meeting of the Board of Directors.

TRANSFER AGENT

    The transfer agent and registrar for the Common Stock is UMB Bank, whose 
mailing address is P.O. Box 419226, Kansas City, Missouri 64141.

                                 LEGAL MATTERS

    The legality of the shares of Common Stock offered hereby will be passed
upon for the Company by Cline, Williams, Wright, Johnson & Oldfather, Omaha,
Nebraska.

                                       8
<PAGE>
                                    PART II
                     EXPENSES OF ISSUANCE AND DISTRIBUTION


Registration Fees................................ $   893.75
Federal and State Taxes..........................          0
Transfer Agent Fees..............................          0
Costs of printing and engraving.................. $   500.00
Legal fees....................................... $ 5,000.00
Accounting fees.................................. $ 3,500.00
Engineering Fees.................................          0

    Total                                         $ 9,893.75

                         INDEMNIFICATION OF DIRECTORS,
                       OFFICERS AND CONTROLLING PERSONS

    The provision regarding indemnification of directors and officers is 
found in the Bylaws of the Company which are incorporated by reference to 
Exhibit (3)(ii) to the Annual Report on Form 10-K for the year ended July 28, 
1995.

    Insofar as indemnification for liabilities arising under the Securities 
Act of 1933 may be permitted to directors, officers or persons controlling 
the registrant pursuant to the foregoing provisions, the registrant has been 
informed that in the opinion of the Securities and Exchange Commission such 
indemnification is against public policy as expressed in the Act and is 
therefore unenforceable.

                                       EXHIBITS

EXHIBIT NUMBER     EXHIBIT

       3.1         Amended and Restated Articles of Incorporation restated
                   through July 25, 1985  (incorporated by reference to 
                   Exhibit 3.1 to the Registration Statement on 
                   Form S-1 (File No. 2-99303)).

       3.2         By-laws of the Company, as amended and restated through
                   September 21, 1995 (incorporated by reference to 
                   Exhibit (3)(ii) to the Annual Report on Form 10-K for 
                   the year ended July 28, 1995).

         5         Opinion of Counsel

      23.1         Independent Auditor's Consent

      23.2         Consent of Counsel (included in Exhibit 5)

                                       9
<PAGE>

                                  UNDERTAKINGS

    The undersigned registrant hereby undertakes:

    (1)  To file, during any period in which offers or sales are being made, a
         post-effective amendment to this registration statement:

         To include any material information with respect to the plan of
         distribution not previously disclosed in the registration statement or
         any material changes to such information in the registration
         statement.

    (2)  That, for the purpose of determining any liability under the
         Securities Act of 1933, each such post-effective amendment shall be
         deemed to be a new registration statement relating to the securities
         offered therein, and the offering of such securities at that time
         shall be deemed to be the initial bona fide offering thereof.

    (3)  To remove from registration by means of a post-effective amendment any
         of the securities being registered which remain unsold at the
         termination of the offering.

    The undersigned registrant hereby undertakes that, for purposes of 
determining any liability under the Securities Act of 1933, each filing of 
the registrant's annual report pursuant to section 13(a) or section 15(d) of 
the Securities Exchange Act of 1934 (and, where applicable, each filing of an 
employee benefit plan's annual report pursuant to section 15(d) of the 
Securities Exchange Act of 1934) that is incorporated by reference in the 
registration statement shall be deemed to be a new registration statement 
relating to the securities offered therein, and the offering of such 
securities at that time shall be deemed to be the initial bona fide offering 
thereof.

    The undersigned registrant hereby undertakes to deliver or cause to be 
delivered with the prospectus, to each person to whom the prospectus is sent 
or given, the latest annual report to security holders that is incorporated 
by reference in the prospectus and furnished pursuant to and meeting the 
requirements of Rule 14a-33 or Rule 14c-3 under the Securities Exchange Act 
of 1934; and, where interim financial information required to be presented by 
Article 10 of Regulation S-X is not set forth in the prospectus, to deliver, 
or cause to be delivered to each person to whom the prospectus is sent or 
given, the latest quarterly report that is specifically incorporated by 
reference in the prospectus to provide such interim financial information.

                                       10
<PAGE>

                                    SIGNATURES

    THE REGISTRANT, pursuant to the requirements of the Securities Act of 
1933, certifies that it has reasonable grounds to believe that it meets all 
of the requirements for filing on Form S-3 and has duly caused this 
registration statement to be signed on its behalf by the undersigned, 
thereunto duly authorized, in the City of Lincoln, State of Nebraska on 
November 24, 1997.

                                  ISCO, Inc.

                                  By: /s/ Philip M. Wittig
                                     -----------------------------------------
                                     Philip M. Wittig, Assistant Secretary, 
                                     Treasurer and Chief Financial Officer

    Pursuant to the requirements of the Securities Act of 1933, this 
Registration Statement has been signed by the following persons in the 
capacities and on the dates indicated.

/s/ Robert W. Allington              Chairman and Director         11/25/97
- ----------------------------------
Robert W. Allington


/s/ Douglas M. Grant                 Director, President           11/25/97
- ----------------------------------   And Chief Operating Officer
Douglas M. Grant


/s/ Dale L. Young                    Director and Secretary        11/25/97
- ----------------------------------
Dale L. Young


/s/ James L. Carrier                 Director                      11/25/97
- ----------------------------------
James L. Carrier


/s/ Philip M. Wittig                 Director, Assistant           11/25/97
- ----------------------------------   Secretary,
Philip M. Wittig                     Treasurer and Chief Financial
                                     Officer


/s/ James L. Linderhom               Director                      11/25/97
- ----------------------------------
James L. Linderhom


/s/ John J. Brasch                   Director                      11/25/97
- ----------------------------------
John J. Brasch

                                       11
<PAGE>


<PAGE>



                                      EXHIBIT 5


                     CLINE, WILLIAMS, WRIGHT, JOHNSON & OLDFATHER
                             1125 SOUTH 103RD, SUITE 720
                                  OMAHA, NE.  68124



                           November 24, 1997



Mr. Douglas M. Grant
President and Chief Operating Officer
Isco, Inc.
4700 Superior Street
Lincoln, NE.  68504-1398

    Re:  Registration Statement on Form S-3

Dear Mr. Grant:

    We have acted as legal counsel for Isco, Inc., a Nebraska corporation, 
(the "Company") in connection with the Company's preparation of the 
above-referenced Registration Statement on Form S-3 (the "Form S-3") being 
filed with the Securities and Exchange Commission (the "Commission") under 
the Securities Act of 1933, as amended, (the "Act") and the prospectus (the 
"Prospectus").  The Form S-3 and the Prospectus relate to the registration by 
the Company of 318,853 shares of Common Stock (the "Shares") owned by John M. 
Klebba, David W. Benbow, Douglas E. Walliser, Cletus A. Kolb, Kenneth L. 
Hultman, Dennis E. Gunderson, Garry G. Southard, Neal B. Gronlie, A. Geary 
Foulk and Carol H. Lucas.

    In connection herewith, we have examined: (i) the Form S-3 and the 
Prospectus; (ii) the Articles of Incorporation, as amended, and the Bylaws as 
amended, of the Company; (iii) the corporate minutes and proceedings of the 
Company applicable to filing of the Form S-3; (iv) such other proceedings, 
documents and records as we deem necessary or appropriate for the purpose of 
making this opinion.  In making such examinations, we have assumed the 
genuineness of all signatures on all documents and conformed originals to all 
copies submitted to us as conformed or photocopies.

In addition to such examination, we have ascertained or verified such 
additional facts as we deem necessary or appropriate for purposes of this 
opinion. However, as to various questions of fact material to our opinion, we 
have relied upon representations, statements or certificates of officers, 
directors, or representatives of the Company or others.

                                       12
<PAGE>
November 24, 1997
Page 2


    Based upon the foregoing, we are of the opinion that: (i) the Company has 
been legally incorporated and is validly existing under the laws of the state 
of Nebraska; and (ii) the Shares have been validly issued, and are fully paid 
and non-assessable shares of Common Stock of the Company.

    We hereby consent to the filing of this opinion as an exhibit to the 
Form S-3 and to any references to our firm in the Prospectus.  In giving this 
consent we do not admit that we have come within the category of persons 
whose consent is required under Section 7 of the Act or the Rules and 
Regulations of the Commission promulgated thereunder.

                                  Very truly yours,


                                  CLINE, WILLIAMS, WRIGHT, 
                                     JOHNSON & OLDFATHER

                                       13


<PAGE>



                                     EXHIBIT 23.1



INDEPENDENT AUDITORS' CONSENT


We consent to the incorporation by reference in this Registration Statement 
of Isco, Inc. on Form S-3 of our report dated September 26, 1997, appearing 
in the Annual Report on Form 10-K of Isco, Inc. and subsidiaries for the year 
ended July 25, 1997.

DELOITTE & TOUCHE LLP

Lincoln, Nebraska
November 24, 1997

                                       14



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