APPLERA CORP
S-8, EX-5, 2000-12-11
LABORATORY ANALYTICAL INSTRUMENTS
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                                                               [logo]Applera
                                                                     Corporation

                                                         761 Main Avenue
                                                         Norwalk, CT  06859-0199

December 11, 2000



Applera Corporation
761 Main Avenue
Norwalk, CT 06859-0001

Ladies and Gentlemen:

         This opinion is being rendered in connection with the preparation and
filing by Applera Corporation (the "Company") of a Registration Statement on
Form S-8 (the "Registration Statement") under the Securities Act of 1933, as
amended (the "Securities Act"), with respect to the proposed sale of up to
10,000,000 shares (the "Shares") of Applera Corporation - Applied Biosystems
Group Common Stock, par value $.01 per share (the "Common Stock"), of the
Company pursuant to the Applera Corporation/Applied Biosystems Group 1999 Stock
Incentive Plan (the "Plan").

         For purposes of the opinion expressed herein, I have conducted such
investigations of law and fact as I have deemed necessary or appropriate.

         Based upon the foregoing, I am of the opinion that, assuming that there
shall have been compliance with the applicable provisions of the Securities Act
and of state securities or "blue sky" laws and that the consideration received
for the Shares is not less than the par value thereof, upon the issuance and
delivery of the Shares in accordance with the terms of the Plan, the Shares will
be legally issued, fully paid and non-assessable.

         The foregoing opinion is limited to the federal laws of the United
States of America and the General Corporation Law of the State of Delaware, and
I am expressing no opinion as to the effect of the laws of any other
jurisdiction.

         I hereby consent to the use of this opinion as an Exhibit to the
Registration Statement and to the reference to me in Item 5 of the Registration
Statement, and any amendments thereto filed in connection with the Plan.

                                                     Very truly yours,

                                                     /s/ Thomas P. Livingston

                                                     Thomas P. Livingston
                                                     Secretary


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