COLLEGE RETIREMENT EQUITIES FUND
SC 13G, 1999-02-11
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                  SCHEDULE 13G
                                 (Rule 13d-102)

                   INFORMATION TO BE INCLUDED IN STATEMENTS
                   FILED PURSUANT TO RULES 13d-1(b)(c), AND
                        (d) AND AMENDMENTS THERETO FILED
                            PURSUANT TO RULE 13d-2(b)
                                (Amendment No. )*


                         GUILFORD PHARMACEUTICALS, INC.
                  ------------------------------------------
                                (Name of Issuer)

                                  COMMON STOCK
                  ------------------------------------------
                         (Title of Class of Securities)

                                   401829106
                        ------------------------------
                                 (CUSIP Number)

                                December 31, 1998
            -------------------------------------------------------
            (Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

(x) Rule 13d-1(b)
( ) Rule 13d-(c)
( ) Rule 13d-1(d)

- ----------------
*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).

                        (Continued on following page(s))
                               Page 1 of 10 Pages



<PAGE>




CUSIP No. 401829106                 13G               Page 2 of 10 Pages


1.    NAME OF REPORTING PERSONS
      I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

      College Retirement Equities Fund
      I.R.S. #13-6022-042


2.    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*           (a) ( )
                                                                  (b) (X)
      See Exhibit A Attached

3.    SEC USE ONLY


4.    CITIZENSHIP OR PLACE OF ORGANIZATION

      New York


NUMBER OF SHARES BENEFICIALLY OWNED
BY EACH REPORTING PERSON WITH:

      5.    SOLE VOTING POWER                   1,661,400

      6.    SHARED VOTING POWER                 None

      7.    SOLE DISPOSITIVE POWER              None

      8. SHARED DISPOSITIVE POWER               1,661,400 (shared with its 
      investment adviser, TIAA-CREF Investment Management, LLC)


9.    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                        1,661,400

10.   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
      SHARES*                                            (  )


11.   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                        8.505%

12.   TYPE OF REPORTING PERSON*

                        IV

                     * SEE INSTRUCTION BEFORE FILLING OUT!



<PAGE>




CUSIP No. 401829106                 13G               Page 3 of 10 Pages


1.    NAME OF REPORTING PERSONS
      I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

      TIAA Separate Account VA-1
      I.R.S. #13-1624203


2.    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*           (a) ( )
                                                                  (b) (X)
      See Exhibit A Attached

3.    SEC USE ONLY


4.    CITIZENSHIP OR PLACE OF ORGANIZATION

      New York


NUMBER OF SHARES BENEFICIALLY OWNED
BY EACH REPORTING PERSON WITH:

      5.    SOLE VOTING POWER                   2,400

      6.    SHARED VOTING POWER                 None

      7.    SOLE DISPOSITIVE POWER              None

      8. SHARED DISPOSITIVE POWER               2,400 (shared with its 
      investment adviser, Teachers Advisors, Inc.)

9.    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                        2,400

10.   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
      SHARES*                                            (  )


11.   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                        0.012%

12.   TYPE OF REPORTING PERSON*

                        IV


                     * SEE INSTRUCTION BEFORE FILLING OUT!



<PAGE>




CUSIP No. 401829106                 13G               Page 4 of 10 Pages


1.    NAME OF REPORTING PERSONS
      I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

      TIAA-CREF Mutual Funds
      I.R.S. #13-3930560 (Growth Equity Fund)


2.    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*   (a) ( )
                                                          (b) (X)
      See Exhibit A Attached

3.    SEC USE ONLY


4.    CITIZENSHIP OR PLACE OF ORGANIZATION

      Delaware


NUMBER OF SHARES BENEFICIALLY OWNED
BY EACH REPORTING PERSON WITH:

      5.    SOLE VOTING POWER                   54,380

      6.    SHARED VOTING POWER                 None

      7.    SOLE DISPOSITIVE POWER              None

      8.    SHARED DISPOSITIVE POWER            54,380 
      (shared with its investment adviser, Teachers Advisors, Inc.)

9.    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                        54,380

10.   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
      SHARES*                                             (  )


11.   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                        0.278%

12.   TYPE OF REPORTING PERSON*

                        IV


                     * SEE INSTRUCTION BEFORE FILLING OUT!



<PAGE>



CUSIP No. 401829106                   13G                 Page 5 of 10 Pages


1.    NAME OF REPORTING PERSONS
      I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

      NYS College Choice Tuition LLC ("NYS Tuition LLC")
      I.R.S. #13-4024889


2.    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    (a) ( )
                                                           (b) (X)
      See Exhibit A Attached

3.    SEC USE ONLY


4.    CITIZENSHIP OR PLACE OF ORGANIZATION

      New York


NUMBER OF SHARES BENEFICIALLY OWNED
BY EACH REPORTING PERSON WITH:

      5.    SOLE VOTING POWER                   None

      6.    SHARED VOTING POWER                 1,414
                                                (Shared with Teachers Advisors,
                                                Inc.)

      7.    SOLE DISPOSITIVE POWER              None

      8. SHARED DISPOSITIVE POWER               1,414 
      (shared with Teachers Advisors, Inc., its investment adviser)

9.    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                        1,414

10.   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
      SHARES*                                            (  )


11.   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                  0.007%

12.   TYPE OF REPORTING PERSON*

                        OO


                     * SEE INSTRUCTION BEFORE FILLING OUT!



<PAGE>



                                                      Page 6 of 10 Pages

Item 1(a).        NAME OF ISSUER:

                  GUILFORD PHARMACEUTICALS, INC.

Item 1(b).        ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES:

                  6611 Tributary Street
                  Baltimore, MD 21222

Item 2(a).        NAME OF PERSON FILING:
                  (1) College Retirement Equities Fund ("CREF")  
                  (2) TIAA Separate Account VA-1 ("VA-1") 
                  (3) TIAA-CREF Mutual Funds ("Mutual Funds") 
                  (4) NYS College Choice Tuition LLC ("NYS Tuition LLC")

Item 2(b).        ADDRESS OF PRINCIPAL BUSINESS OFFICE:
                  (1)   CREF -      730 Third Avenue
                                    New York, N.Y.  10017
                  (2)   VA-1 -      730 Third Avenue
                                    New York, N.Y.  10017
                  (3)   Mutual      730 Third Avenue
                        Funds -     New York, N.Y. 10017
                  (4)   NYS
                        Tuition     730 Third Avenue
                        LLC -       New York, N.Y. 10017

Item 2(c).        CITIZENSHIP:
                  (1) CREF - Incorporated in New York 
                  (2) VA-1 - Established in New York 
                  (3) Mutual Funds - Incorporated in Delaware 
                  (4) NYS Tuition LLC - Organized in New York

Item 2(d).        TITLE OF CLASS OF SECURITIES:
                  Common Stock

Item 2(e).        CUSIP NUMBER:  401829106

Item        3. IF THIS STATEMENT IS FILED PURSUANT TO RULES 13d-1(b), OR
            13d-2(b) or (c), CHECK WHETHER THE PERSON FILING IS A:

(a)   ( )   Broker or dealer registered under Section 15 of the
            Exchange Act.
(b)   ( )   Bank as defined in Section 3(a)(6) of the Exchange Act. (c) ( )
            Insurance company as defined in Section 3(a)(19) of the
            Exchange Act.
(d)   (x)   Investment Company registered under Section 8 of the Investment
            Company Act.
(e)   ( )   An investment adviser in accordance with Rule 13d-
            1(b)(1)(ii)(E);
(f)   ( )   An employee benefit plan or endowment fund in accordance with
            Rule 13d-1(b)(1)(ii)(F);
(g)   ( )   A parent holding company or control person in accordance with
            Rule 13d-1(b)(1)(ii)(G);
(h)   ( )   A savings association as defined in Section 3(b) of the
            Federal Deposit Insurance Act;



<PAGE>




                                                              Page 7 of 10 Pages

(i)   ( )   A church plan that is excluded from the definition of an
            investment company under Section 3(c)(14) of the
            Investment Company Act;
(j)   (x)   Group, in accordance with Rule 13d-1(b)(1)(ii)(J).

If this statement is filed pursuant to Rule 13d-1(c), check this box.  (  )

Item 4.     OWNERSHIP.

(1)   COLLEGE RETIREMENT EQUITIES FUND
      (a)    Amount Beneficially Owned:  1,661,400
      (b)    Percent of Class:  8.505%
      (c)    The Board of Trustees of CREF, an investment company, has sole 
      power to vote 1,661,400 shares of common stock and authority to direct the
      disposition of the 1,661,400 shares of common stock. TIAA-CREF Investment
      Management, LLC, CREF's investment adviser, is authorized to sell the
      1,661,400 shares on behalf of CREF in its discretion, subject to the
      ultimate authority of the CREF Board of Trustees.

(2)   TIAA SEPARATE ACCOUNT VA-1
      (a)    Amount Beneficially Owned: 2,400
      (b)    Percent of Class:  0.012%
      (c)    The management committee of VA-1, an investment company, has sole
      power to vote 2,400 shares of common stock, and authority to direct the
      disposition of the 2,400 shares of common stock. Teachers Advisors, Inc.,
      VA-1's investment adviser, is authorized to sell the 2,400 shares on
      behalf of VA-1 in its discretion, subject to the ultimate authority of the
      VA-1 Management Committee.

(3)   TIAA-CREF MUTUAL FUNDS
      (a)    Amount Beneficially Owned: 54,380 
      (b)    Percent of Class: 0.278% 
      (c)    The Board of Trustees of the Mutual Funds, an investment company, 
      has sole power to vote 54,380 shares of common stock, and authority to
      direct the disposition of the 54,380 shares of common stock. Teachers
      Advisors, Inc., the Mutual Fund's investment adviser, is authorized to
      sell the 54,380 shares on behalf of the Mutual Funds in its discretion,
      subject to the ultimate authority of the Mutual Funds Board of Trustees.

(4)   NYS COLLEGE CHOICE TUITION LLC 
      (a)    Amount Beneficially Owned: 1,414 
      (b)    Percent of Class: 0.007% 
      (c)    The members of the NYS Tuition LLC have delegated to Teachers 
      Advisors, Inc., a registered investment adviser,the power to vote and
      direct the disposition of the 1,414 shares of common stock on behalf of
      the NYS Tuition LLC in its discretion, subject to the ultimate authority
      the members of NYS Tuition LLC.


<PAGE>



                                                              Page 8 of 10 Pages

Item 5.     OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS.

If this statement is being filed to report the fact that as of the date hereof
the reporting person has ceased to be the beneficial owner of more than five
percent of the class of securities, check the following ( ).

Item 6.     OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER
            PERSON.
                                 Not Applicable

Item 7.     IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH
            ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT
            HOLDING COMPANY.

                                 Not Applicable

Item 8.     IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE
            GROUP.

            See attached Exhibit A.

Item 9.     NOTICE OF DISSOLUTION OF GROUP:           Not Applicable

Item 10.    CERTIFICATION.
            By signing below I certify that, to the best of my knowledge and
            belief, the securities referred to above were acquired and are held
            in the ordinary course of business and were not acquired and are not
            held for the purpose of or with the effect of changing or
            influencing the control of the issuer of the securities and were not
            acquired and are not held in connection with or as a participant in
            any transaction having that purpose or effect.

                                    SIGNATURE

      After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

Date:  February 11, 1999
                                    COLLEGE RETIREMENT EQUITIES FUND


                                    By:   /s/ Peter C. Clapman    
                                          --------------------------------
                                          Peter C. Clapman
                                          Senior Vice President and Chief
                                          Counsel, Investments

                                    TIAA SEPARATE ACCOUNT VA-1


                                    By:   /s/ Peter C. Clapman          
                                          --------------------------------
                                          Peter C. Clapman
                                          Senior Vice President and Chief
                                          Counsel, Investments



<PAGE>





                                                              Page 9 of 10 Pages

                                    TIAA-CREF MUTUAL FUNDS


                                    By:   /s/ Peter C. Clapman          
                                          --------------------------------
                                          Peter C. Clapman
                                          Senior Vice President and Chief
                                          Counsel, Investments

                                    NYS COLLEGE CHOICE TUITION LLC
                                    By:   Teachers Insurance and Annuity
                                          Association of America,
                                          as manager


                                    By:   /s/ Peter C. Clapman          
                                          --------------------------------
                                          Peter C. Clapman
                                          Senior Vice President and Chief
                                          Counsel, Investments



<PAGE>


                                                             Page 10 of 10 Pages

                                    EXHIBIT A

           IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP
           ---------------------------------------------------------


College Retirement Equities Fund - IV 
TIAA Separate Account VA-1 - IV 
TIAA-CREF Mutual Funds - IV 
NYS College Choice Tuition LLC - OO


The College Retirement Equities Fund, TIAA Separate Account VA-1, TIAA-CREF
Mutual Funds and NYS College Choice Tuition LLC (the "Reporting Persons") are
filing as a group because CREF's investment adviser, TIAA-CREF Investment
Management, LLC, is affiliated and employs some of the same investment personnel
as Teachers Advisors, Inc., the investment adviser for TIAA Separate Account
VA-1 and TIAA-CREF Mutual Funds, and NYS College Choice Tuition LLC. However,
because separate investment decisions are made with respect to the respective
portfolio holdings of each of the Reporting Persons and there is no oral or
written agreement or arrangement among the Reporting Persons with respect to
acquisition, voting, disposition or otherwise of their securities, each
Reporting Person disclaims beneficial ownership of the others' securities
holdings and disclaims its membership in a group with the other Reporting
Person, where the purpose of the group is to acquire control of or influence
management of the issuer.





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