COLLEGE RETIREMENT EQUITIES FUND
SC 13G/A, 2000-02-11
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                  SCHEDULE 13G
                                 (Rule 13d-102)

                    INFORMATION TO BE INCLUDED IN STATEMENTS
                    FILED PURSUANT TO RULES 13d-1(b)(c), AND
                        (d) AND AMENDMENTS THERETO FILED
                            PURSUANT TO RULE 13d-2(b)
                               (Amendment No. 1)*


                         Guilford Pharmaceuticals, Inc.
                   ------------------------------------------
                                (Name of Issuer)

                                  Common Stock

                   ------------------------------------------
                         (Title of Class of Securities)

                                    401829106

                         ------------------------------
                                 (CUSIP Number)

                                December 31, 1999
             -------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

(x) Rule 13d-1(b)
( ) Rule 13d-(c)
( ) Rule 13d-1(d)

- ----------------
*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for any  subsequent  amendment  containing  information  which  would  alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).

                        (Continued on following page(s))
                               Page 1 of 11 Pages


<PAGE>


CUSIP No. 401829106               13G                        Page 2 of 11 Pages


1.       NAME OF REPORTING PERSONS
         I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

         College Retirement Equities Fund

         I.R.S. #13-6022-042


2.       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*         (a) ( )
                                                                   (b) (X)
         See Exhibit A Attached

3.       SEC USE ONLY


4.       CITIZENSHIP OR PLACE OF ORGANIZATION

         New York

NUMBER OF SHARES BENEFICIALLY OWNED
BY EACH REPORTING PERSON WITH:

         5.       SOLE VOTING POWER              1,407,900

         6.       SHARED VOTING POWER            None

         7.       SOLE DISPOSITIVE POWER         None

         8.       SHARED DISPOSITIVE POWER       1,407,900 (shared with its
         investment adviser, TIAA-CREF Investment Management, LLC)


9.       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                                     1,407,900

10.      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
         SHARES*
                                     (  )


11.      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                                     6.108%

12.      TYPE OF REPORTING PERSON*

                                     IV

                      * SEE INSTRUCTION BEFORE FILLING OUT!



<PAGE>


CUSIP No. 401829106               13G                        Page 3 of 11 Pages


1.       NAME OF REPORTING PERSONS
         I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

         TIAA Separate Account VA-1
         I.R.S. #13-1624203


2.       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*         (a) ( )
                                                                   (b) (X)
         See Exhibit A Attached

3.       SEC USE ONLY


4.       CITIZENSHIP OR PLACE OF ORGANIZATION

         New York

NUMBER OF SHARES BENEFICIALLY OWNED
BY EACH REPORTING PERSON WITH:

         5.       SOLE VOTING POWER              200

         6.       SHARED VOTING POWER            None

         7.       SOLE DISPOSITIVE POWER         None

         8.       SHARED DISPOSITIVE POWER       200
         (shared with its investment adviser, Teachers Advisors, Inc.)

9.       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                                     200

10.      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
         SHARES*
                                     (  )


11.      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                                     0.001%

12.      TYPE OF REPORTING PERSON*

                                     IV

                      * SEE INSTRUCTION BEFORE FILLING OUT!



<PAGE>


CUSIP No. 401829106               13G                        Page 4 of 11 Pages


1.       NAME OF REPORTING PERSONS
         I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

         TIAA-CREF Mutual Funds
         I.R.S. #13-3930560 (Growth Equity Fund)


2.       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*         (a) ( )
                                                                   (b) (X)
         See Exhibit A Attached

3.       SEC USE ONLY


4.       CITIZENSHIP OR PLACE OF ORGANIZATION

         Delaware

NUMBER OF SHARES BENEFICIALLY OWNED
BY EACH REPORTING PERSON WITH:

         5.       SOLE VOTING POWER              53,980

         6.       SHARED VOTING POWER            None

         7.       SOLE DISPOSITIVE POWER         None

         8.       SHARED DISPOSITIVE POWER       53,980
         (shared with its investment adviser, Teachers Advisors, Inc.)

9.       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                                     53,980

10.      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
         SHARES*
                                     (  )


11.      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                                     0.234%

12.      TYPE OF REPORTING PERSON*

                                     IV

                      * SEE INSTRUCTION BEFORE FILLING OUT!



<PAGE>


CUSIP No. 401829106               13G                        Page 5 of 11 Pages


1.       NAME OF REPORTING PERSONS
         I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

         TIAA-CREF Institutional Mutual Funds
         I.R.S. #13-4055168 (Institutional Growth Equity Fund)


2.       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*         (a) ( )
                                                                   (b) (X)
         See Exhibit A Attached

3.       SEC USE ONLY


4.       CITIZENSHIP OR PLACE OF ORGANIZATION

         Delaware

NUMBER OF SHARES BENEFICIALLY OWNED
BY EACH REPORTING PERSON WITH:

         5.       SOLE VOTING POWER              3,595

         6.       SHARED VOTING POWER            None

         7.       SOLE DISPOSITIVE POWER         None

         8.       SHARED DISPOSITIVE POWER       3,595
         (shared with its investment adviser, Teachers Advisors, Inc.)

9.       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                                     3,595

10.      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
         SHARES*
                                     (  )


11.      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                                     0.016%

12.      TYPE OF REPORTING PERSON*

                                     IV

                      * SEE INSTRUCTION BEFORE FILLING OUT!


<PAGE>


CUSIP No. 401829106               13G                        Page 6 of 11 Pages


1.       NAME OF REPORTING PERSONS
         I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

         NYS College Choice Tuition LLC ("NYS Tuition LLC")
         I.R.S. #13-4024889


2.       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*         (a) ( )
                                                                   (b) (X)
         See Exhibit A Attached

3.       SEC USE ONLY


4.       CITIZENSHIP OR PLACE OF ORGANIZATION

         New York

NUMBER OF SHARES BENEFICIALLY OWNED
BY EACH REPORTING PERSON WITH:

         5.       SOLE VOTING POWER              None

         6.       SHARED VOTING POWER            4,836
                                                 (Shared with Teachers
                                                 Insurance and Annuity
                                                 Association ("TIAA"),
                                                 Teachers Advisors, Inc.
                                                 and the Comptroller of
                                                 the State of New York)

         7.       SOLE DISPOSITIVE POWER         None

         8.       SHARED DISPOSITIVE POWER       4,836
         (shared with TIAA and Teachers Advisors, Inc., its investment adviser)

9.       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                                     4,836

10.      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
         SHARES*
                                     (  )


11.      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                                     0.021%

12.      TYPE OF REPORTING PERSON*

                                     OO

                      * SEE INSTRUCTION BEFORE FILLING OUT!



<PAGE>


                                                              Page 7 of 11 Pages

Item 1(a).        NAME OF ISSUER:

                  Guilford Pharmaceuticals, Inc.

Item 1(b).        ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES:

                  6611 Tributary Street
                  Baltimore, MD 21222

Item 2(a).        NAME OF PERSON FILING:
                  (1)  College Retirement Equities Fund ("CREF")
                  (2)  TIAA Separate Account VA-1 ("VA-1")
                  (3)  TIAA-CREF Mutual Funds ("Mutual Funds")
                  (4)  TIAA-CREF Institutional Mutual Funds
                       ("Institutional")
                  (5)  NYS College Choice Tuition LLC
                       ("NYS Tuition LLC")

Item 2(b).        ADDRESS OF PRINCIPAL BUSINESS OFFICE:
                  (1)  CREF -          730 Third Avenue
                                       New York, N.Y.  10017
                  (2)  VA-1 -          730 Third Avenue
                                       New York, N.Y.  10017
                  (3)  Mutual          730 Third Avenue
                       Funds -         New York, N.Y. 10017
                  (4)  Institutional - 730 Third Avenue
                                       New York, N.Y. 10017
                  (5)  NYS
                       Tuition         730 Third Avenue
                       LLC -           New York, N.Y. 10017


Item 2(c).        CITIZENSHIP:
                  (1) CREF - Incorporated in New York
                  (2) VA-1 - Established in New York
                  (3) Mutual Funds - Incorporated in Delaware
                  (4) Institutional - Incorporated in Delaware
                  (5) NYS Tuition LLC - Organized in New York

Item 2(d).        TITLE OF CLASS OF SECURITIES:
                  Common Stock

Item 2(e).        CUSIP NUMBER: 401829106

Item 3.           IF THIS STATEMENT IS FILED PURSUANT TO RULES 13d-1(b), OR
                  13d-2(b) or (c), CHECK WHETHER THE PERSON FILING IS A:

(a)      ( )      Broker or dealer  registered  under Section 15 of the Exchange
                  Act.
(b)      ( )      Bank as defined in Section 3(a)(6) of the Exchange Act.
(c)      ( )      Insurance  company  as  defined  in  Section  3(a)(19)  of the
                  Exchange Act.
(d)      (x)      Investment   Company   registered   under  Section  8  of  the
                  Investment Company Act.
(e)      ( )      An   investment   adviser   in   accordance   with  Rule  13d-
                  1(b)(1)(ii)(E);
(f)      ( )      An employee  benefit plan or endowment fund in accordance with
                  Rule 13d-1(b)(1)(ii)(F);


<PAGE>


                                                              Page 8 of 11 Pages

(g)      ( )      A parent holding  company or control person in accordance with
                  Rule 13d-1(b)(1)(ii)(G);
(h)      ( )      A  savings  association  as  defined  in  Section  3(b) of the
                  Federal Deposit Insurance Act;
(i)      ( )      A church  plan  that is  excluded  from the  definition  of an
                  investment  company under Section  3(c)(14) of the  Investment
                  Company Act;
(j)      (x)      Group, in accordance with Rule 13d-1(b)(1)(ii)(J).

If this statement is filed pursuant to Rule 13d-1(c), check this box. ( )

Item 4.           OWNERSHIP.

(1)      COLLEGE RETIREMENT EQUITIES FUND
         (a) Amount Beneficially Owned: 1,407,900
         (b) Percent of Class: 6.108%
         (c) The Board of  Trustees of CREF,  an  investment  company,  has sole
         power to vote 1,407,900  shares of common stock and authority to direct
         the  disposition  of the 1,407,900  shares of common  stock.  TIAA-CREF
         Investment Management, LLC, CREF's investment adviser, is authorized to
         sell the 1,407,900 shares on behalf of CREF in its discretion,  subject
         to the ultimate authority of the CREF Board of Trustees.

(2)      TIAA SEPARATE ACCOUNT VA-1
         (a) Amount Beneficially Owned: 200
         (b) Percent of Class: 0.001%
         (c) The management  committee of VA-1, an investment company,  has sole
         power to vote 200 shares of common  stock,  and authority to direct the
         disposition of the 200 shares of common stock. Teachers Advisors, Inc.,
         VA-1's  investment  adviser,  is  authorized  to sell the 200 shares on
         behalf of VA- 1 in its discretion, subject to the ultimate authority of
         the VA-1 Management Committee.

(3)      TIAA-CREF MUTUAL FUNDS
         (a) Amount Beneficially Owned: 53,980
         (b) Percent of Class: 0.234%
         (c) The Board of Trustees of the Mutual Funds,  an investment  company,
         has sole power to vote 53,980 shares of common stock,  and authority to
         direct the  disposition of the 53,980 shares of common stock.  Teachers
         Advisors,  Inc., the Mutual Fund's investment adviser, is authorized to
         sell the 53,980 shares on behalf of the Mutual Funds in its discretion,
         subject  to  the  ultimate  authority  of the  Mutual  Funds  Board  of
         Trustees.

(4)      TIAA-CREF INSTITUTIONAL MUTUAL FUNDS
         (a) Amount Beneficially Owned: 3,595
         (b) Percent of Class: 0.016%
         (c) The Board of Trustees of the Institutional,  an investment company,
         has sole power to vote 3,595 shares of common  stock,  and authority to
         direct the  disposition  of the 3,595 shares of common stock.  Teachers
         Advisors,  Inc., the Institutional's  investment adviser, is authorized
         to  sell  the  3,595  shares  on  behalf  of the  Institutional  in its
         discretion,  subject to the  ultimate  authority  of the  Institutional
         Board of Trustees.


<PAGE>


                                                              Page 9 of 11 Pages

(5)      NYS College Choice Tuition LLC
         (a) Amount Beneficially Owned: 4,836
         (b) Percent of Class: 0.021%
         (c) TIAA,  as manager of the NYS Tuition LLC, has the power to vote the
         4,836 shares of common stock,  although The Comptroller of the State of
         New York may,  at its  discretion,  notify TIAA that it intends to make
         voting  decisions  with  respect  to the  shares.  TIAA  also  has  the
         authority, as manager of the NYS Tuition LLC, to direct the disposition
         of the 4,836  shares of common  stock on behalf of the NYS Tuition LLC,
         in its  discretion.  TIAA  has  delegated  its  voting  and  investment
         management   authority  to  Teachers   Advisors,   Inc.,  a  registered
         investment adviser.

Item 5.           OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS.

If this statement is being filed to report the fact that as of the date hereof
the reporting person has ceased to be the beneficial owner of more than five
percent of the class of securities, check the following ( ).

Item 6.           OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER
                  PERSON.

                                   Not Applicable

Item 7.           IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH
                  ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT
                  HOLDING COMPANY.

                                   Not Applicable

Item 8.           IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE
                  GROUP.

                  See attached Exhibit A.

Item 9.           NOTICE OF DISSOLUTION OF GROUP:       Not Applicable

Item 10.          CERTIFICATION.
                  By signing  below I certify  that, to the best of my knowledge
                  and belief, the securities referred to above were acquired and
                  are  held in the  ordinary  course  of  business  and were not
                  acquired  and are not  held  for the  purpose  of or with  the
                  effect of changing or influencing the control of the issuer of
                  the  securities  and  were  not  acquired  and are not held in
                  connection with or as a participant in any transaction  having
                  that purpose or effect.


<PAGE>


                                                             Page 10 of 11 Pages

                                    SIGNATURE

         After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

Date: February 11, 2000
                                       COLLEGE RETIREMENT EQUITIES FUND


                                        By: /s/ PETER C. CLAPMAN
                                            -----------------------------------
                                            Peter C. Clapman
                                            Senior Vice President and Chief
                                            Counsel, Investments

                                       TIAA SEPARATE ACCOUNT VA-1


                                       By:  /s/ PETER C. CLAPMAN
                                            -----------------------------------
                                            Peter C. Clapman
                                            Senior Vice President and Chief
                                            Counsel, Investments

                                       TIAA-CREF MUTUAL FUNDS


                                       By:  /s/ PETER C. CLAPMAN
                                            -----------------------------------
                                            Peter C. Clapman
                                            Senior Vice President and Chief
                                            Counsel, Investments

                                       TIAA-CREF INSTITUTIONAL MUTUAL FUNDS


                                       By:  /s/ PETER C. CLAPMAN
                                            -----------------------------------
                                            Peter C. Clapman
                                            Senior Vice President and Chief
                                            Counsel, Investments

                                       NYS COLLEGE CHOICE TUITION LLC
                                       By:  Teachers Insurance and Annuity
                                            Association of America,
                                            as manager


                                       By:  /s/ PETER C. CLAPMAN
                                            -----------------------------------
                                            Peter C. Clapman
                                            Senior Vice President and Chief
                                            Counsel, Investments


<PAGE>


                                                             Page 11 of 11 Pages

                                    EXHIBIT A

            IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP
            ---------------------------------------------------------


College Retirement  Equities Fund - IV TIAA Separate Account VA-1 - IV TIAA-CREF
Mutual Funds - IV TIAA-CREF  Institutional  Mutual Funds - IV NYS College Choice
Tuition LLC - OO

The College  Retirement  Equities Fund,  TIAA Separate  Account VA-1,  TIAA-CREF
Mutual  Funds,  TIAA-CREF  Institutional  Mutual  Funds and NYS  College  Choice
Tuition  LLC (the  "Reporting  Persons")  are filing as a group  because  CREF's
investment  adviser,  TIAA-CREF  Investment  Management,  LLC, is affiliated and
employs some of the same investment  personnel as Teachers  Advisors,  Inc., the
investment  adviser  for TIAA  Separate  Account  VA-1,TIAA-CREF  Mutual  Funds,
TIAA-CREF  Institutional  Mutual  Funds  and NYS  College  Choice  Tuition  LLC.
However,  because  separate  investment  decisions  are made with respect to the
respective  portfolio  holdings of each of the Reporting Persons and there is no
oral or written  agreement  or  arrangement  among the  Reporting  Persons  with
respect to acquisition,  voting,  disposition or otherwise of their  securities,
each Reporting Person disclaims  beneficial  ownership of the others' securities
holdings  and  disclaims  its  membership  in a group  with the other  Reporting
Person,  where the  purpose of the group is to acquire  control of or  influence
management of the issuer.



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