DIANON SYSTEMS INC
8-K, 1999-05-05
MEDICAL LABORATORIES
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                      SECURITIES AND EXCHANGE COMMISSION

                            Washington, D.C. 20549

                                   Form 8-K

                                CURRENT REPORT

    Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934



         Date of Report (Date of earliest event reported) May 1, 1999


                             DIANON Systems, Inc.
            (Exact name of registrant as specified in its charter)



         Delaware                   000-19392                 06-1128081
- --------------------------------------------------------------------------------
      (State or other            (Commission File            (IRS Employer
       jurisdiction
     of incorporation)               Number)              Identification No.)



200 Watson Boulevard, Stratford, Connecticut                     06615
- --------------------------------------------------------------------------------
(Address of principal executive offices)                        (Zip Code)



Registrant's telephone number, including area code   (203) 381-4000
                                                     --------------




- ------------------------------------------------------------------------------
        (Former name or former address, if changed since last report.)


                                       1
<PAGE>


Item 2.        Acquisition or Disposition of Assets.

      On May 1, 1999  (the  "Effective  Date"),  pursuant  to an Asset  Purchase
Agreement dated as of April 7, 1999 among DIANON Systems,  Inc. (the "Company"),
Kyto Meridien Diagnostics,  L.L.C.  ("KMD"),  Kyto Diagnostics,  L.P., ("Kyto"),
Meridian  Diagnostics  Labs,  Inc., A. Bruce Shapiro and Ralph M. Richart,  M.D.
(the  "Asset  Purchase  Agreement"),  the Company  acquired  from KMD all of the
assets of KMD (except  certain  excluded  assets)  related to KMD's  business of
owning and operating  laboratories  that provide anatomic,  pathology,  surgical
pathology  and clinical  laboratory  testing  services to patients,  physicians,
hospitals,  clinics,  managed care organizations and other health care providers
(the  "Business").  On the  Effective  Date,  the Company also  assumed  certain
liabilities of KMD under certain equipment leases and other contracts related to
the Business  together with certain employee related  liabilities.  The purchase
price  consisted of (i) cash payments and  transaction  costs of $10,500,000 and
$200,000,  respectively (ii) 300,000 shares of the Company's common voting stock
valued at $2,465,625 (iii) certain  liabilities  assumed and (iv) within 45 days
of the Closing  Date,  an amount  equal to the  Business's  accounts  receivable
balance  (adjusted for non-current  accounts)  existing on the Closing Date. The
amount of the purchase  price was determined  through arms' length  negotiations
between the Company and KMD. The Company  used  working  capital and its line of
credit facility from First Union National Bank to fund the cash component of the
purchase price. The acquisition will be accounted for under the purchase method.

      In  connection  with the  transaction,  the Company  also  entered  into a
registration rights agreement with KMD pursuant to which the Company granted KMD
certain "piggyback" registration rights in respect of the shares of common stock
issued to KMD as part of the Purchase Price.

      The Company has also  entered  into  certain  employment  agreements  with
certain  employees of KMD. These agreements are attached hereto and incorporated
by reference.

Item 7.        Financial Statements and Exhibits.

(a)   Financial statements of businesses acquired.

   Included as an exhibit are the audited  financial  statements  of KMD for the
year ended December 31, 1998.

(b) Pro forma financial information.

   The following pro forma financial statements give effect for the purchase and
are  presented  for  illustrative  purposes  only.  These  pro  forma  financial
statements are not necessarily indicative of the operating results and financial
position  that might  have been  achieved  had the  purchase  occurred  as of an
earlier  date,  nor are they  necessarily  indicative  of operating  results and
financial position which may occur in the future.

   A pro forma  condensed  balance  sheet is provided  as of  December  31, 1998
giving effect to the purchase as though it had been  consummated on that date. A
pro forma  condensed  statement

                                       2
<PAGE>

of operations is provided for the year ended  December 31, 1998 giving effect to
the purchase as though it had occurred at the beginning of the year.

   The historical  condensed statement of operations for the year ended December
31, 1998 is derived from the  historical  consolidated  financial  statements of
DIANON  Systems,  Inc.  and should be read in  conjunction  with the 1998 Annual
Report on Form 10-K.



                                       3
<PAGE>


<TABLE>


                               DIANON Systems, Inc.
                         Pro Forma Condensed Balance Sheet
                                 December 31, 1998
<CAPTION>

                                                           Pro Forma (unaudited)
                                                         ---------------------------
                                         Historical      Acquisition
                                          Actual          of KMD          Adjusted
                                          ------          ------          --------
      ASSETS

CURRENT ASSETS
<S>                                     <C>             <C>             <C>
     Cash and cash equivalents          $12,126,076     $(4,700,00(a)   $
                                                                          7,426,076
     Accounts receivable, net of         14,403,878                      14,403,878
       allowances
     Other current assets                 3,036,342        123,000(a)     3,159,342
                                         ----------      ----------      -----------
            Total current assets         29,566,296     (4,577,000)      24,989,296

PROPERTY AND EQUIPMENT, net               5,534,485        400,000(a)     5,934,485

INTANGIBLE ASSETS,  net of                  377,751     12,972,625(a)    13,350,376
accumulated amortization

OTHER NONCURRENT ASSETS                   1,224,583                       1,224,583
                                         ==========      ==========      ===========
            TOTAL ASSETS                $36,703,115     $8,795,625      $45,498,740
                                         ==========      ==========      ===========



      LIABILITIES AND STOCKHOLDERS' 
      EQUITY

BANK LOANS                                   -           $6,000,000(a)   $6,000,000
OTHER CURRENT LIABILITIES               $5,239,376          330,000(b)    5,569,376
                                         ----------      ----------      -----------
            Total current liabilities    5,239,376       6,330,000       11,569,376

LONG-TERM PORTION OF CAPITALIZED            80,675                           80,675
   LEASE OBLIGATIONS
                                         ----------      ----------      -----------
            Total liabilities            5,320,051       6,330,000       11,650,051
                                         ----------      ----------      -----------

STOCKHOLDERS' EQUITY
     Common stock, par value $.01           68,088             780 (a)       68,868
     Additional paid-in capital         27,398,120         683,991 (a)   28,082,111
     Retained earnings                   5,697,710                        5,697,710
     Common stock held in treasury, at  (1,780,854)     1,780,854 (a)       -
       cost                              ----------      ----------      -----------
            Total stockholders' equity   31,383,064      2,465,625       33,848,689
                                         ----------      ----------      -----------

TOTAL  LIABILITIES  AND   STOCKHOLDERS' $36,703,115     $8,795,625      $45,498,740
  EQUITY                                 ==========      ==========      ===========

See  accompanying  notes  to  pro  forma financial statements

</TABLE>



                                       4
<PAGE>

<TABLE>


                              DIANON Systems, Inc.
                   Pro Forma Condensed Statement of Operations
                                December 31, 1998
<CAPTION>

                                                               Pro Forma (unaudited)
                                                      ----------------------------------------
                                          Historical  Acquisition
                                           Actual       of KMD      Adjustments  Adjusted
                                           ------       ------      -----------  --------

<S>                                      <C>         <C>          <C>           <C>        
NET REVENUES                             $62,181,503 $14,631,433                $76,812,936
COST OF SALES                             35,670,153   7,035,159                 42,705,312
                                          ----------  -----------   ----------   ----------

      GROSS PROFIT                        26,511,350   7,596,274                 34,107,624

SELLING, GENERAL AND ADMINISTRATIVE       21,464,737   6,318,288     $783,754 (c)28,566,779
EXPENSES
RESEARCH AND DEVELOPMENT EXPENSES           528,478       -             -          528,478
                                          ----------  -----------   ----------   ----------

      INCOME FROM OPERATIONS              4,518,135    1,277,986    (783,754) (c)5,012,367
INTEREST INCOME, NET                        682,138        5,330    (595,000) (c)   92,468
                                          ----------  -----------   ----------   ----------

    INCOME  BEFORE  PROVISION  FOR INCOME 5,200,273    1,283,316    (1,378,754)  5,104,835
     TAXES 
PROVISION FOR INCOME TAXES                2,245,943       -          (41,038) (c)2,204,905
                                          ----------  -----------   ----------   ----------

      NET INCOME                          $2,954,330  $1,283,316    $(1,337,716) $2,899,930
                                          ==========  ===========   ==========   ==========


      EARNINGS PER SHARE
         BASIC                                $0.44                                  $0.42
         DILUTED                              $0.43                                  $0.40

      WEIGHTED AVERAGE SHARES OUTSTANDING
         BASIC                            6,677,524      300,000                 6,977,524
         DILUTED                          6,902,080      300,000                 7,202,080


See  accompanying   notes  to  pro  forma financial statements

</TABLE>





                                       5
<PAGE>

DIANON SYSTEMS, INC.
NOTES TO PRO FORMA FINANCIAL STATEMENTS (UNAUDITED)

Note 1.        BASIS OF PRESENTATION

      The pro forma financial statements are presented for illustrative purposes
only,  giving  effect  for the  purchase  of the  operations  of  Kyto  Meridien
Diagnostics, L.L.C. (KMD).

      The pro forma condensed balance sheet as of December 31, 1998 includes the
impact of all transactions,  whether of a recurring or nonrecurring nature, that
can be reasonably estimated and should be reflected as of that date.

Note 2.        PRO FORMA ADJUSTMENTS

      Pro forma adjustments include amounts as follows:

     (a)  The purchase of  inventory,  prepaid  expenses,  plant and  equipment,
          customer lists and other intangible assets through the payment of cash
          portion of purchase  price and  issuance  of 300,000  shares of common
          stock,  222,019 of which were from treasury stock. The cash portion of
          the purchase price,  exclusive of transaction  costs of $200,000,  was
          financed  through the draw down of $6,000,000  from the company's line
          of credit and the use of $4,500,000 of the company's cash.

     (b)  Accrual of employee related benefit costs.

     (c)  Amortization  of  intangible  assets,  loss  of  interest  income  and
          interest expense on acquisition  debt, all net of related tax effects.
          Includes a provision  for income taxes for acquired  company which had
          been  organized  as a  partnership  and as such,  did not  reflect any
          provision for income taxes in its financial statements.

   The  pro  forma   financial   statements   do  not  reflect  any  savings  or
efficiencies, if any, which will arise upon the integration of KMD's general and
administrative functions into DIANON.

(c)   Exhibits.

      10.1  Asset  Purchase  Agreement  dated as of April 7, 1999  among  DIANON
Systems,  Inc.,  Kyto Meridien  Diagnostics,  L.L.C.,  Kyto  Diagnostics,  L.P.,
Meridian Diagnostics Labs, Inc., A. Bruce Shapiro and Ralph M. Richart, M.D.

      10.2 Registration  Rights Agreement dated as of May 1, 1999 between DIANON
Systems, Inc. and Kyto Meridien Diagnostics, L.L.C.

      10.3 Consulting Agreement dated May 1, 1999 by and between DIANON Systems,
Inc. and A. Bruce Shapiro

      10.4 Employment Agreement dated May 1, 1999 by and between DIANON Systems,
Inc. and Ralph M. Richart, M.D.


                                       6
<PAGE>

      10.5 Employment Agreement dated May 1, 1999 by and between DIANON Systems,
Inc. and Beth Phillips

      10.6 Employment Agreement dated May 1, 1999 by and between DIANON Systems,
Inc. and Dana Shapiro

      23 Auditors consent

      99.1 Press Release

      99.2 KMD financial statements for the year ending December 31, 1998


                                  Signatures



Pursuant  to the  requirements  of the  Securities  Exchange  Act of  1934,  the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.

                                    DIANON Systems, Inc.


May 4, 1999                         /s/ DAVID R. SCHREIBER
- ------------------                  -------------------------------------------
      Date                          David R. Schreiber
                                    Senior Vice President, Finance and 
                                    Chief Financial Officer
                                    (Principal Financial and Accounting Officer)




                                       7



                                                                  EXHIBIT 10.1
                           ASSET PURCHASE AGREEMENT
                           ------------------------




      ASSET PURCHASE AGREEMENT, dated as of April 7, 1999 (the "Agreement"),  by
and among DIANON SYSTEMS, INC., a Delaware corporation ("Buyer"),  KYTO MERIDIEN
DIAGNOSTICS,  L.L.C.,  a  New  York  limited  liability  company  ("KMD"),  KYTO
DIAGNOSTICS,  L.P., a New York limited  partnership  and Member of KMD ("Kyto"),
MERIDIEN  DIAGNOSTICS  LABS,  INC.,  a New York  corporation  and  Member of KMD
("Meridien")  (Kyto and Meridien being hereinafter  collectively  referred to as
the  "Members"),  A.  Bruce  Shapiro,  a  Principal  and  indirect  owner of KMD
("Shapiro"),  and Ralph M. Richart,  M.D., a Principal and indirect owner of KMD
("Richart") (KMD,  Members,  Shapiro and Richart being hereinafter  collectively
referred to as the "Sellers" and each, individually, as a "Seller").

                             W I T N E S S E T H:
                             --------------------

      WHEREAS,   KMD  is  engaged  in  the  business  of  owning  and  operating
laboratories that provide anatomic  pathology,  surgical  pathology and clinical
laboratory testing services to patients, physicians, hospitals, clinics, managed
care organizations and other health care providers (the "Business"); and

      WHEREAS,  KMD desires to sell to Buyer, and Buyer desires to purchase from
KMD,  certain  assets  of KMD  used in  connection  with  the  Business,  all in
accordance  with the terms and subject to the conditions  hereinafter set forth;
and

      WHEREAS,  the Members are the only direct  owners of KMD and are  entering
into this Agreement as an inducement to Buyer to enter into this Agreement.

      NOW, THEREFORE,  in consideration of the premises and the mutual covenants
hereinafter contained, the parties hereto, intending to be legally bound, hereby
agree as follows:

      1.    DEFINITIONS: RULES OF CONSTRUCTION.

      (a) Definitions.  The following terms, as used herein,  have the following
meanings:

      "Acquisition  Documents"  shall mean,  collectively,  this Asset  Purchase
Agreement, the New City Lease, the Bill of Sale and Assignment, the Registration
Rights Agreement and the Employment and Consulting Agreements, together with all
Exhibits and Schedules hereto and thereto.

      "Affiliate" means, as to any Person,  any other Person which,  directly or
indirectly,  controls,  is  controlled  by or is under common  control with such
Person.  For the purposes of this definition,  "control" means the possession of
the power to direct or cause the  direction of  management  and policies of such
Person,  whether  through the  ownership  of voting  securities,  by contract or
otherwise.

      "Assets" shall have the meaning set forth in Section 2(a).

      "Assumed  Contracts,"  "Assumed  Obligations"  and "Assumption  Agreement"
shall have the respective meanings set forth in Section 2(d).


<PAGE>

      "Benefit Plans" shall have the meaning set forth in Section 4(n).

      "Bill of Sale  and  Assignment"  shall  have the  meaning  set  forth in
Section 2(c).

      "Business  Day" means any day other than Saturday,  Sunday,  and any other
day on which banks are not generally open for business in New York City.

      "CHAMPUS"  shall mean the federal  Civilian Health and Medical Plan of the
Uniformed Services.

      "Closing" and "Closing Date" shall have the respective  meanings set forth
in Section 11.

      "Consulting  Agreement"  means the three year agreement for the consulting
services of Shapiro,  to be entered  into as of the Closing  Date in the form of
EXHIBIT A hereto.

      "Code" means the Internal Revenue Code of l986, as amended.

      "Contract" means any contract,  agreement,  indenture, note, bond, loan or
credit agreement,  instrument,  security  agreement,  conditional or installment
sales  contract,   mortgage,  lease,  license,   franchise,   insurance  policy,
commitment or other binding understanding or arrangement.

      "Employment  Agreements"  means the three agreements for the employment of
Richart,  Beth  Phillips  and Dana  Shapiro,  each to be entered  into as of the
Closing  Date  in  their  respective  forms  set  forth  in  EXHIBIT  B  hereto.
"Employment  Agreement"  means  such of the three  Employment  Agreements  as is
indicated by the context.

      "Environmental  Laws"  means any  federal,  state,  local or  foreign  law
(including common law),  statute,  code,  ordinance,  rule,  regulation or other
requirement relating in any way to the environment, natural resources, or public
or  employee   health  and  safety  and  includes,   without   limitation,   the
Comprehensive Environmental Response Compensation,  and Liability Act, 42 U.S.C.
ss. 9601 et seq., the Hazardous Materials Transportation Act, 49 U.S.C. ss. 1801
et seq., the Federal Insecticide,  Fungicide,  and Rodenticide Act, 7 U.S.C. ss.
136 et seq., the Resource  Conservation  and Recovery Act, 42 U.S.C. ss. 6901 et
seq., the Toxic  Substances  Control Act, 15 U.S.C.  ss. 2601 et seq., the Clean
Air Act, 42 U.S.C.  ss. 7401 et seq., the Clean Water Act, 33 U.S.C. ss. 1251 et
seq., the Occupational Safety and Health Act, 29 U.S.C. ss. 651 et seq., and the
Oil Pollution  Act of 1990,  33 U.S.C.  ss. 2701 et seq., as such laws have been
amended or supplemented,  and the regulations  promulgated pursuant thereto, and
all analogous state and local statutes.

      "ERISA" means the Employee  Retirement Income Security Act of 1974 (or any
successor legislation thereto), as amended from time to time.

      "Excluded Assets" shall have the meaning set forth in Section 2(b).

      "Facilities" means KMD's laboratory testing facilities and offices located
at 216 Congers  Road,  New City,  New York 10956 ("New City  Facility"),  and 40
Crossways Park Drive, Woodbury, New York 11797 ("Woodbury Facility").

      "Federal  Health  Care  Program"  shall have the  meaning set forth in SSA
Section 1128B(f).


                                       2
<PAGE>

      "GAAP" means generally accepted accounting principles in the United States
of  America  as in  effect  from  time to time  set  forth in the  opinions  and
pronouncements of the Accounting  Principles Board and the American Institute of
Certified  Public  Accountants  and the  statements  and  pronouncements  of the
Financial  Accounting Standards Board, which are applicable to the circumstances
as of the date of determination.

      "Governmental   Body"  means  any  country,   government  or  governmental
regulatory body thereof,  any political  subdivision  thereof (whether  federal,
state,  local or  foreign),  any agency,  instrumentality  or  authority  of any
country or any government, or any court of competent jurisdiction.

      "Hazardous  Material"  means any  substance,  material  or waste  which is
regulated  by any  Governmental  Body of the  United  States  or other  national
government  including  any  material,  substance  or waste which is defined as a
"hazardous  waste,"  "hazardous  material,"  "hazardous  substance,"  "extremely
hazardous waste," "restricted hazardous waste,"  "contaminant," "toxic waste" or
"toxic substance" under any provision of Environmental  Law, which includes (but
is not limited to) petroleum,  petroleum products,  asbestos,  urea formaldehyde
and polychlorinated biphenyls.

      "Intellectual  Property  Right" means any trademark,  service mark,  trade
name, patent,  trade secret,  copyright,  know-how or other type of intellectual
property right (including any  registrations or applications for registration of
any of the foregoing).

      "Key Persons" means Richart, Shapiro and Dana Shapiro.

      "Lease"  means  the  agreement  for the  lease  by  Buyer  of the New City
Facility, to be entered into as of the Closing Date substantially in the form of
EXHIBIT C hereto.

      "Lien" means any  mortgage,  claim,  encumbrance,  deed of trust,  pledge,
hypothecation,  assignment, deposit arrangement, encumbrance, lien (statutory or
other),  security interest or preference,  priority or other security agreement,
right of first offer or first refusal, or other preferential  arrangement of any
kind or nature whatsoever.

      "Material Adverse Effect" means a material adverse effect on the financial
condition, results of operations,  business,  properties, Assets, liabilities or
prospects of KMD or the Business.

      "Member"  means any Person who has been admitted as a member of KMD or who
has a membership or other ownership interest in KMD.

      "Person" means any individual,  corporation,  limited  liability  company,
partnership, firm, joint venture, association, trust, Governmental Body or other
entity.

      "Purchase  Price"  shall  mean  the sum of the  First,  Second  and  Third
Components, as described in Section 3(a).

      "Registration  Rights  Agreement"  means  that  agreement  in the  form of
EXHIBIT D hereto  extending to KMD certain  registration  rights with respect to
the Shares.


                                       3
<PAGE>

      "Release" means any release, spill, emission,  leaking,  pumping, pouring,
dumping, emptying, injection, deposit, disposal, discharge,  dispersal, leaching
or migration on or into the indoor or outdoor  environment or into or out of any
property.

      "Retained Liabilities" shall have the meaning set forth in Section 2(d).

      "Shares" shall have the meaning set forth in Section 3(a).

      "SSA"  shall mean the  federal  Social  Security  Act and all  regulations
promulgated pursuant thereto.

      "State  Health  Care  Program"  shall  have the  meaning  set forth in SSA
Section 1128(h).

      "Taxes"  means  all  taxes,  charges,   fees,  levies,  or  other  similar
assessments,  including (a) income, gross receipts, ad valorem, premium, excise,
real  property,  personal  property,  windfall  profit,  sales,  use,  transfer,
licensing, withholding,  employment, payroll, alternative or add-on minimum tax,
estimated and franchise taxes imposed by any federal,  state,  local, or foreign
government,  or any  subdivision,  agency,  or other similar  person of any such
government; and (b) any interest, fines, penalties, assessments, or additions to
tax resulting from, attributable to, or incurred in connection with any such tax
or any contest or dispute thereof.

      "Tax Returns" means any report,  return,  statement,  or other information
required to be supplied to a taxing authority in connection with Taxes.

      (b) Rules of Construction.  As used in this Agreement,  the words "herein,
"hereof,"  "hereto" and  "hereunder"  and other words of similar import refer to
this Agreement as a whole,  including the Schedules and Exhibits hereto,  as the
same  may  from  time  to  time  be  amended  or  supplemented,  and  not to any
subdivision  contained in this Agreement.  The word "including" when used herein
is not intended to be exclusive and means "including,  without  limitation." The
term "Seller's  knowledge,"  "Sellers' knowledge," "to the knowledge of Seller,"
"to the  knowledge  of Sellers" or similar  terms  means the  collective  actual
knowledge of Sellers and the actual knowledge of each individual  Seller,  after
diligent inquiry.

       2.    PURCHASE AND SALE.

      (a) Assets. Upon the terms and subject to the conditions set forth in this
Agreement, KMD shall, at the Closing, sell, assign, convey, transfer and deliver
to Buyer,  free and clear of all Liens, and Buyer shall purchase and accept from
KMD, all of KMD's right, title and interest in and to all assets, properties and
rights of every kind and  description,  wherever  located,  whether  tangible or
intangible, other than the Excluded Assets referred to in Section 2(b), owned by
KMD and relating to or arising out of the Business  (collectively the "Assets"),
including, without limitation, the following:

       (i) all  laboratory,  clinical or chemical  testing and other  equipment,
computers,  furnishings,  furniture,  office  supplies,  vehicles,  spare parts,
tools,  machinery  or other  equipment  owned  by KMD and all  other  goods  and
personal property used in the operation of the Business,  all of which items are
listed,  specifically  or by  category,  on Schedule  2(a)(i)(A)  (in each case,
including all accessories,  supplies,  operating manuals and other documentation
with respect thereto,  collectively,  the  "Equipment");  KMD's interests in the
leases of Equipment listed on Schedule 2(a)(i)(B) (collectively,  the "Equipment
Leases");


                                       4
<PAGE>

and all  other  fixed  assets  owned by KMD and that are  located  at one of the
Facilities or otherwise used in the Business,  including the fixed assets listed
on Schedule 2(a)(i)(C) (collectively, the "Fixed Assets");

      (ii) all inventories of supplies,  chemicals,  labels, stationary,  forms,
packing,  shipping and mailing  materials  owned by KMD and used in the Business
(collectively, the "Inventory");

      (iii) all Contracts of KMD to provide services,  equipment and real estate
leases, equipment maintenance agreements,  software license agreements,  service
agreements,  reagent  agreements and other  agreements  incurred in the ordinary
course of the Business (but excluding all Excluded Contracts and Benefit Plans),
any  and  all  rights  of KMD  thereunder,  and  all  rights  of KMD  under  any
non-disclosure,  confidentiality  or  noncompetition  Contracts  relating to the
Business (the "Included Contracts"), all of which Included Contracts (other than
such agreements that are terminable without penalty on less than thirty-one (31)
days  notice or  involve  payments  of not more than $500 per month and not more
than $30,000 in the  aggregate  over the life of such  contracts)  are listed on
Schedule 2(a)(iii) or 2(a)(i)(B);

      (iv)  all   rights  of  KMD   under  or   pursuant   to  all   warranties,
representations  or guarantees made by suppliers,  manufacturers and contractors
in  connection  with  products  or  services  of, or used in, the  Business,  or
otherwise affecting the Equipment, the Fixed Assets or the Inventory;

      (v) all customer and vendor lists  relating to the Business,  all files or
documents  relating to customers and vendors of the Business,  and all financial
records, files, books or documents otherwise relating to the Assets, the Assumed
Obligations and/or the Business, including computer programs, manuals, sales and
advertising  materials,  billing records,  and sales,  distribution and purchase
correspondence;

      (vi) all Intellectual Property Rights of KMD and all of KMD's rights under
all Third  Party  Licenses  (as defined in Section  4(l)) and all  documentation
relating  thereto in whatever media it is embodied,  including  books,  records,
computer storage media,  magnetic tape, data  compilations and other embodiments
are listed on Schedule 2(a)(vi);

      (vii)  subject  to the  license  granted  by Section  7(e),  all  computer
software  (including  object code and source code in KMD's  possession) owned by
KMD and used by KMD in connection with the Business, including all copies stored
in magnetic or other media of any kind, and all documentation and specifications
relating thereto;

      (viii) all permits, licenses,  provider numbers and other formal approvals
issued  by any  Governmental  Body held and used by KMD in  connection  with the
Business (other than KMD's Medicare Provider Number L220810 issued by the Health
Care Financing  Administration  and pertaining to Medicare services performed at
the  Facilities)  to the extent  transferable  to Buyer,  all of which  material
permits, licenses and provider numbers are listed on Schedule 2(a)(viii);

      (ix) all prepaid deposits, expenses or charges of the Business;

      (x) all claims, choses of action and rights relating to the Business,  the
Assets and the Assumed  Obligations,  and all insurance  proceeds,  judgments or
settlements   with  respect  to  the  Business,   the  Assets  and  the  Assumed
Obligations;


                                       5
<PAGE>


      (xi) all of KMD's  right,  title  and  interest  in and to the name  "Kyto
Meridien  Diagnostics" and any derivation  thereof,  the goodwill  pertaining to
such name and the  Business,  and the current  telephone  numbers and  telephone
listings of the Business; and

      (xii) all current  accounts  receivable  existing on the Closing  Date for
which no payment has been received by KMD as of the first posting date after the
Closing Date and which  originated  from billings to monthly billed  accounts of
KMD (as  opposed  to  patient  and third  party  billed  accounts  described  in
Subsection   2(b)(vii)   below),   together  with  all  evidences   thereof  and
documentation relating thereto (the "Purchased Receivables").

      (b) Excluded Assets. Notwithstanding anything to the contrary contained in
Section 2(a), KMD is not hereunder selling, assigning, transferring or conveying
to Buyer, and Buyer is not assuming any liability or obligation with respect to,
the following  assets  pertaining to the Business  (collectively,  the "Excluded
Assets");

      (i) all  Contracts  of KMD listed on  Schedule  2(b)(i) ( the  "Excluded
Contracts");

      (ii) all  Contracts  not listed on a  Schedule  pursuant  to Section  2(a)
above,  unless not required to be listed pursuant to the exceptions set forth in
Subsection  2(a)(iii),  or unless  Buyer,  in its sole  discretion,  accepts the
transfer or assignment of such Contract;

      (iii) any title to any real  property,  except for the leasehold  interest
granted  pursuant  to the New City  Lease  and the  lease of KMD's  facility  in
Woodbury,  New York, and except for Buyer's leasehold  improvements and fixtures
to the Facilities that are Assets;

      (iv) all Benefit Plans, except as expressly provided herein;

      (v) KMD's only Medicare  Provider  Number  L220810  pertaining to Medicare
services  performed  at the  Facilities  and  the  Medicare  provider  agreement
pursuant to which such provider number was issued;

      (vi) all assets  described on Schedule  2(b)(vi),  the aggregate  value of
which assets shall not exceed a fair market  value of fifty  thousand  ($50,000)
dollars.  Notwithstanding their listing as Excluded Assets on Schedule 2(b)(vi),
the following  Excluded  Assets shall remain on site in their current  locations
for a period of one  hundred  and twenty  (120) days after the Closing and Buyer
shall have shared access and use of such Excluded Assets as reasonably  required
by Buyer:  In New City, the HP952 computer and disk drives,  six terminals,  DAT
drive and related  printer;  In  Woodbury,  the Compu Add  computer,  dual array
Seagate drive,  Colorado Power DAT, Intel Pentium system, two Compustar personal
computers,  three Hewlett  Packard III SI laser  printers and one Epson DFX 8000
line printer;

      (vii) KMD's  accounts  receivable  originating  from billings  directly to
patients  and third  party  insurers  (as opposed to the  Purchased  Receivables
described  in  Subsection  2(a)(xii)  above),  including,   without  limitation,
Medicare,  Medicaid and CHAMPUS,  for  services  performed  prior to the Closing
Date; and

      (viii) all cash and cash equivalents.


                                       6
<PAGE>


      (c) Transfer of Title to the Assets.  The sale,  assignment,  transfer and
delivery by KMD of the Assets  shall be made at the Closing and  evidenced  by a
duly executed Bill of Sale and Assignment substantially in the form of EXHIBIT E
hereto  (the "Bill of Sale and  Assignment")  and by such other  instruments  of
transfer and  assignment as Buyer shall  reasonably  request in order to vest in
Buyer,  as of the Closing Date,  title to the Assets which are owned and a valid
and assignable  leasehold or other contractual  interest in the Assets which are
leased or otherwise held under Contract,  in each case free and clear of any and
all material Liens. Sellers covenant and agree to execute and deliver such other
and further  instruments  of  assignment,  transfer or  conveyance of any of the
Assets as Buyer  may  reasonably  request  after the  Closing  Date to  evidence
Buyer's right, title and interest in and to the Assets.

      (d) Assumed Obligations:  Retained Liabilities. On the Closing Date, Buyer
shall assume, perform and discharge the obligations and liabilities of KMD under
the  Equipment  Leases and the Included  Contracts  (collectively,  the "Assumed
Contracts")  pursuant to an Assumption  Agreement  substantially  in the form of
EXHIBIT F hereto (the  "Assumption  Agreement"),  provided that Buyer shall have
received all necessary  consents with respect to the assignment thereof to Buyer
and provided further that Buyer shall assume KMD's obligations under the Assumed
Contracts  only to the extent that (i) Sellers'  representations  and warranties
with  respect to the  Assumed  Contracts  are true and  correct in all  material
respects and (ii) such  obligations  of  performance  arise and relate to events
occurring on or after the Closing Date.

      No other  liabilities  or  obligations  of  Sellers  are  expressly  or by
implication  being assumed by Buyer under this Agreement.  Without  limiting the
generality of the preceding  sentence,  Sellers shall retain all obligations and
liabilities (known or unknown,  contingent or fixed, liquidated or unliquidated,
accrued or  unaccrued,  "Liabilities")  relating to,  arising out of or accruing
from the operation of the Business prior to the Closing Date, including, without
limitation:  any and all  obligations  of KMD for  performance  under  Contracts
(other than obligations for performance arising after the Closing Date under the
Assumed  Contracts);  any and all Taxes with respect to the  operation of KMD or
the Business or the  ownership,  use or leasing of any of the Assets on or prior
to the Closing Date; any and all Liabilities pertaining to any time period prior
to the Closing Date under any  Environmental  Law; any and all Liabilities  with
respect to any Benefit Plan; any and all Liabilities  arising from any claims in
respect of, or other obligations pertaining to, the Excluded Assets; any and all
Liabilities with respect to professional liability claims pertaining to any time
period prior to the Closing Date;  any and all  Liabilities  with respect to the
accounts  payable or other  current  liabilities  of KMD  pertaining to any time
period prior to the Closing Date;  any and all  Liabilities of Sellers under any
Clinical Laboratory  Improvements Act ("CLIA") license or provider number of KMD
pertaining  to any time period  prior to the  Closing  Date  including,  without
limitation,  the KMD Medicare  provider  agreement and Medicare  provider number
L220810  pertaining  to services  performed at the  Facilities;  and any and all
Liabilities  with  respect to any false  claims,  civil or criminal  enforcement
actions,  civil money penalties,  administrative  sanctions or other Liabilities
related to any overpayment  for services  performed by or billed by or on behalf
of KMD prior to the Closing Date (collectively, the "Retained Liabilities") .

      (e) Payment of Accounts  Payable.  Sellers shall pay all accounts  payable
and other current  liabilities of KMD not expressly  assumed by Buyer  hereunder
within thirty days of receipt of the invoice for payment  therefore,  but, in no
event, more than ninety days after the Closing Date.  Failure of Sellers to make
payment as required by this  Subsection (e), unless Sellers possess a good faith
defense to payment,  shall be an indemnifiable event under Subsection 15(a)(vii)
below,  but  indemnification  therefore  shall not be subject  to the  Threshold
described in Section 15(e).  Assuring that all such accounts payable and 


                                       7
<PAGE>

current  liabilities  are timely paid shall be a material  obligation of Shapiro
under the Consulting Agreement.

      (f) Books and  Records.  At the  Closing,  KMD shall  deliver to Buyer all
books of account,  leases,  other  agreements,  customer lists,  files and other
documents,  instruments  and papers of all kind and nature  belonging to KMD and
relating  to the  Business  (other  than the  Excluded  Assets),  whether in the
possession of KMD or any Member.

      3.     PURCHASE PRICE.

      (a)    Purchase Price and Restrictive Covenant Payments.

      Subject to the provisions below, the aggregate payment to be made by Buyer
to  Sellers  for  the  Assets,  including  compensation  to  Sellers  for  their
restrictive  covenants  provided  in  Section 14 below,  shall  consist of three
components as follows:

            First Component.  Buyer shall, at the Closing,  pay to KMD an amount
      equal to ten million  five  hundred  thousand  ($10,500,000)  dollars (the
      "Closing  Payment"),  less the Withholding  described in Subsection  3(d),
      below.  Such Closing  Payment  shall be paid by Buyer by wire  transfer of
      immediately  available  funds to the account  designated in writing by KMD
      not less than three (3) Business Days prior to the Closing Date.

            Second  Component.  Buyer shall,  at the  Closing,  deliver to KMD a
      certificate for three hundred thousand  (300,000) newly issued or treasury
      shares of the common voting stock, par value $.01 per share, of Buyer (the
      "Shares").

            Third  Component.  Within  forty-five  days after the Closing  Date,
      Buyer  shall pay to KMD an amount  equal to the current  monthly  accounts
      receivable balance (with respect to the Purchased Receivables described in
      Subsection  2(a)(xii))  existing  on the  Closing  Date less the  payments
      received after the Closing Date by KMD or any of the Sellers in payment of
      such Purchased Receivables.  KMD shall have an absolute obligation to post
      payment for any  receivable  subject to this  provision  for which KMD has
      received  payment.  Buyer  shall  have the right to audit  the  applicable
      portions of the books and records of KMD to determine whether any payments
      for the  Purchased  Receivables  have  been  received  by it and KMD shall
      refund to Buyer any payments made by Buyer under this section to which KMD
      is not entitled.

      (b)  Allocation  of  Purchase  Price.  Buyer and  Sellers  agree  that the
Purchase Price of the Assets will be allocated as set forth on EXHIBIT G hereto,
provided that the  allocation  to the Sellers'  restrictive  covenants  required
under  Section 14 below shall in no way reflect or be  construed as a ceiling on
the amount of damages that may be claimed or incurred by Buyer in the event of a
breach by any Seller of the  requirements of Section 14 or any of the Employment
or  Consulting  Agreements.  Buyer  shall have no duty or  obligation  as to the
disbursement or division of the Purchase Price  consideration among the Sellers.
Subject to the  requirements  of any  applicable  Tax law,  all Tax  Returns and
reports  filed by Buyer  and by KMD  shall be  prepared  consistently  with such
allocation.

      (c) Collection of Purchased Receivables. Buyer shall have the right at any
time after the Closing Date to endorse,  deposit and cash any checks received in
full or part  payment  for any of the  Purchased  Receivables  and any  accounts
receivable pertaining to services performed after the Closing Date, whether such
checks are made  payable  to the order of KMD or  otherwise.  KMD hereby  grants
Buyer an  irrevocable  power of attorney for the purpose of  endorsing  any such
checks or other  funds  payable to the order of KMD.  Sellers  shall  deliver to
Buyer  any and all  checks  or money  received  by KMD or any  Seller  after the
Closing in full or part  payment of any  Purchased  Receivable  and any accounts
receivable  pertaining to services performed on or after the Closing


                                       8
<PAGE>

Date. Buyer shall refund to Sellers any pre-Closing  receivables collected by it
that are not Purchased Receivables.

      (d) Sales Tax Withholding.  At least ten days prior to the Closing,  Buyer
shall file a  `Notification  of Sale,  Transfer or  Assignment in Bulk' with the
State of New York, Department of Taxation and Finance.  Prior to Closing,  Buyer
shall  estimate,  based upon the allocation of purchase price  determined by its
accountants,  the amount of the sales tax that is likely to be owing on the sale
of the Assets under the New York State Sales and Use Tax Law ("Estimated  Tax").
Buyer shall  withhold an amount equal to one-half of such Estimated Tax from the
Closing Payment set forth in Subsection  3(a), above (the  "Withholding").  Upon
receipt from the New York State Tax Commission of notice of the actual amount of
sales tax due ("Actual Tax"), Buyer shall pay such Actual Tax in full,  one-half
of which  Actual Tax shall be paid from the  Withholding.  In the event that the
Withholding exceeds one-half of the Actual Tax determined to be due, the balance
of the Withholding  (that portion in excess of one-half of the Actual Tax) shall
be paid by Buyer to KMD. In the event that the Withholding is less than one-half
of the Actual Tax  determined to be due, KMD shall pay to Buyer  one-half of the
difference  between the Actual Tax and the  Estimated  Tax. The  obligations  of
Buyer  and  KMD  under   this   Section   3(d)  shall  not  be  subject  to  the
indemnification threshold set forth in Section 15(e), below.

      4. REPRESENTATIONS AND WARRANTIES OF THE SELLERS. Sellers hereby severally
represent and warrant to Buyer as follows and acknowledge  that Buyer is relying
upon such  representations  and warranties in connection  with the  transactions
provided for herein:

      (a)  Organization,  Etc.  KMD  is a  limited  liability  corporation  duly
organized,  validly existing and in good standing as a limited liability company
under  the  laws of the  State  of New  York  and has all  requisite  power  and
authority to (i) conduct its Business as it is now conducted,  (ii) own or lease
all of the properties owned or leased by it and (iii) enter into and perform its
obligations  under the  Acquisition  Documents.  KMD is duly qualified and is in
good standing in each  jurisdiction  where the nature of its business makes such
qualification  necessary.  True,  correct and complete copies of the Articles of
Organization  of KMD  (together  with all  amendments  thereto and  restatements
thereof as of the date hereof) have been previously delivered to Buyer.

            Kyto is a limited  partnership duly organized,  validly existing and
in good  standing  as a limited  partnership  under the laws of the State of New
York and has all the requisite power and authority to enter into and perform its
obligations under this Agreement. Kyto is duly qualified and is in good standing
in each jurisdiction  where the nature of its business makes such  qualification
necessary.  True,  correct  and  complete  copies  of  the  Limited  Partnership
Agreement of Kyto (together with all amendments thereto and restatements thereof
as of the date hereof) have been previously delivered to Buyer.

            Meridien is a  Subchapter  S  corporation  duly  organized,  validly
existing and in good standing as an S corporation under the laws of the State of
New York and has all the requisite power and authority to enter into and perform
its obligations  under this  Agreement.  Meridien is duly qualified as a foreign
corporation and is in good standing in each jurisdiction where the nature of its
business makes such qualification  necessary.  True, correct and complete copies
of the  Articles of  Incorporation  and By-


                                       9
<PAGE>

Laws of Meridien (together with all amendments thereto and restatements  thereof
as of the date hereof) have been previously delivered to Buyer.

      (b)  Authorization,  Execution,  Binding  Effect.  Each of the Sellers has
taken all actions necessary to authorize it to execute,  deliver and perform its
obligations  under  this  Agreement  and  the  Acquisition   Documents  and  the
consummation  by each  of  them of the  transactions  provided  for  herein  and
therein.  This Agreement has been, and the other  Acquisition  Documents will at
Closing  have been,  duly and  validly  executed  and  delivered  by KMD and the
Members and (assuming the due  authorization,  execution and delivery thereof by
Buyer),  the  Acquisition  Documents  constitute  the legal,  valid and  binding
obligations of KMD and the Members,  enforceable  against KMD and the Members in
accordance  with  their  terms,  except  as  enforceability  may be  limited  by
bankruptcy, insolvency, reorganization or other laws affecting creditors' rights
and  remedies  generally  and by general  principles  of equity  (regardless  of
whether such enforceability is considered in a proceeding in equity or at law).

      (c)  No  Conflicting  Agreements  or  Charter  Provisions,  Consents.  The
execution, delivery, compliance with and performance of the terms and provisions
of the  Acquisition  Documents  will not  conflict  with or result in a material
breach of the terms,  conditions  or  provisions  of, or  constitute  a material
default  (or an  event  which,  with  notice,  lapse of  time,  or  both,  would
constitute a material default) under, or result in any material  violation of or
require the consent of any Person  under (i) the  Articles  of  Organization  or
operating  agreement  of KMD or any  resolutions  adopted by the Members of KMD,
(ii) except as set forth on Schedule  4(c),  any  provision  of any  Contract to
which KMD is a party or by which  any  property  of KMD may be bound,  (iii) any
Intellectual  Property Right of any Person or constitute the misappropriation of
any trade secret of any Person,  or (iv) any order,  judgment,  decree,  permit,
statute,  law,  rule or  regulation  of any  Governmental  Body to which  KMD is
subject or by which any of its  properties  or Assets is bound.  The  execution,
delivery and  performance  of this  Agreement will not result in the creation of
any material Lien upon the Business  conveyed to Buyer  hereunder or any part of
the  Assets or  properties  of KMD.  Except as set forth on  Schedule  4(c),  no
consent,  waiver,  approval order, permit or authorization of, or declaration or
filing with, or notification to, any Person or Governmental  Body is required on
the part of KMD or the Members in connection  with the execution and delivery of
the Acquisition Documents or compliance with any of the provisions thereof.

      (d) Litigation.  Except as set forth on Schedule 4(d), there is no action,
suit, proceeding or investigation pending or, to Sellers' knowledge, threatened,
at law or in equity,  in or before any  Governmental  Body (i) to which KMD is a
party or by which any of its  properties  or Assets is bound,  (ii)  against any
employee or Member of KMD in connection with the Business,  or (iii) questioning
or otherwise  affecting the validity of the Acquisition  Documents or any action
taken  or  to  be  taken  pursuant  to or in  connection  with  the  Acquisition
Documents.

      (e)  Financial  Statements.  KMD has  delivered to Buyer copies of (i) the
unaudited balance sheets of Buyer as at September 30, 1997,  September 30, 1998,
November 30, 1998 and December 31, 1998 and the related unaudited  statements of
income of KMD for the  years-to-date  then  ended  (such  unaudited  statements,
including the related notes and schedules thereto, are referred to herein as the
"Financial  Statements").  Each of the  Financial  Statements  is  complete  and
correct in all material respects,  has been prepared in accordance with GAAP and
in  conformity   with  the  practices   consistently   applied  by  KMD  without
modification  of the  accounting  principles  used  in the  preparation  thereof
(except  insofar  as tests of  materiality  may have been  applied by KMD to the
Business and Assets taken as a whole and for the absence of comprehensive  notes
thereto) and presents fairly the financial  position,  results of operations and
cash  flows of KMD as at the  dates  and for the  periods  indicated.  KMD shall
update such  


                                       10
<PAGE>

Financial Statements as of the month ended February 28, 1999. Schedule 3(a) sets
forth a true,  accurate and complete list of the  pre-Closing  current  accounts
receivable of KMD as of the Closing Date.  Sellers understand that the Financial
Statements of KMD must be audited pursuant to Securities and Exchange Commission
regulations governing Buyer. Sellers have cooperated fully (and will continue to
cooperate   fully  as  requested  by  Buyer  for  Buyer's   preparation  of  its
post-Closing  SEC filings) with the auditing firms  designated by Buyer to audit
the  Financial  Statements  of KMD by providing  them with truthful and complete
information and required  representations  and  documentation and such access to
the books,  records and accounts of KMD as requested by them and have not failed
to provide  such  auditors  with any fact,  information  or document  within the
knowledge,  possession  or  control  of  Sellers,  or any  of  them,  which  was
explicitly requested by such auditors.

      (f)  Ownership.  Kyto and  Meridien  are the only two  Members  of KMD and
collectively  own all of the right,  title and interest and all other equity and
beneficial  ownership  interests in and to KMD. KMD has no subsidiaries and does
not own, directly or indirectly, or control any equity or voting interest in any
Person.  Except for their interest in KMD, none of the Members has, nor has had,
since January 1, 1997, any direct or indirect  ownership interest (other than an
interest  of less  than two  percent  in a  publicly  held  company  traded on a
national securities exchange) in any business that conducts or has conducted any
anatomic pathology,  surgical pathology or clinical laboratory testing services.
Except as  disclosed in Schedule  4(f),  neither of the Members  conducts,  nor,
since  January 1, 1997,  has either  Member  conducted  any anatomic  pathology,
surgical pathology or clinical laboratory testing services.

      (g) Environmental  Matters. To Sellers' knowledge,  except as disclosed on
Schedule  4(g): (i) the  operations of KMD are in material  compliance  with all
applicable  Environmental  Laws and all permits issued pursuant to Environmental
Laws;  (ii)  KMD  has  obtained  all  permits   required  under  all  applicable
Environmental  Laws  necessary  to operate  its  business;  (iii) KMD is not the
subject of any outstanding  written order or Contract with any Governmental Body
respecting  (A)  Environmental   Laws,  (B)  remedial  action,  site  treatment,
clean-up,  monitoring  or evaluation  with respect to any  property,  or (C) any
Release or threatened Release of Hazardous  Material;  (iv) KMD has not received
any  written  communication  alleging  that  KMD  may  be in  violation  of  any
Environmental  Law or any permit issued  pursuant to  Environmental  Law, or may
have  any  liability  under  any  Environmental  Law;  (v) KMD does not have any
current  contingent  material  liability in  connection  with any Release of any
Hazardous Materials into the indoor or outdoor  environment  (whether on-site or
off-site);  (vi) there are no  investigations  of the business,  operations,  or
currently or  previously  owned,  operated or leased  property of KMD pending or
threatened which could lead to the imposition of any material liability pursuant
to any Environmental  Law; (vii) there is not located at either Facility any (A)
underground  storage tanks,  (B)  asbestos-containing  material or (C) equipment
containing  polychlorinated  biphenyls; and (viii) KMD has provided to Buyer all
environmentally  related  audits,  studies and reports that have been  performed
with respect to each of the Facilities.

      (h) No  Undisclosed  Liabilities.  Except as reflected on the December 31,
1998  balance  sheet  included in the  Financial  Statements  or as set forth on
Schedule  4(h),  KMD has no material  obligations,  indebtedness  or liabilities
(whether  accrued,  absolute,  contingent  or  otherwise,  and whether due or to
become due) other than such as may have been  incurred or may have arisen  since
the balance sheet date in the ordinary course of the Business.

      (i) Defaults. To Sellers' knowledge, except as set forth on Schedule 4(i),
KMD is not in default or alleged to be in default with respect to any  judgment,
order,  writ,  injunction  or  decree  of  any  


                                       11
<PAGE>

Governmental Body or industry association other than defaults which individually
or in the aggregate would not have a Material Adverse Effect.

      (j)   Compliance with Laws, Regulatory Matters.

            (i)  Except  as set forth on  Schedule  4(j),  KMD:  (A) has made or
obtained  each  registration,   filing,   license,   permit,   certificate,   or
governmental  approval  necessary to enable it to carry on its  Business,  other
than where the lack thereof,  individually or in the aggregate, would not have a
Material  Adverse  Effect;  (B) has complied in all material  respects  with all
laws,  regulations  and orders which are applicable to the Business as presently
conducted,  other than for such  non-compliance  which,  individually  or in the
aggregate,  would not have a Material  Adverse  Effect,  and; (C)  possesses all
material permits, licenses and other governmental approvals,  authorizations and
orders applicable to, or necessary for the conduct of, its Business as presently
conducted  other than where the lack thereof,  individually or in the aggregate,
would not have a Material Adverse Effect. To Sellers'  knowledge,  except as set
forth in Schedule 4(j), KMD has obtained all material governmental approvals and
all other  approvals,  consents,  certifications  and  waivers  and has made all
filings, given all material notices and otherwise complied with all governmental
laws,  rules and regulations  which are required on the part of KMD in order for
KMD to enter into,  perform and otherwise  consummate the transactions  provided
for  in  the  Acquisition  Documents.  No  Seller  has  received  notice  of any
deficiency in or violation of any  applicable  law, rule,  regulation,  license,
permit, or requirement of any governmental authority relating to the Business or
Assets,  nor is any Seller  aware of any facts  which  could  result in any such
notice or which may constitute any material  deficiency or violation.  Except as
set forth on Schedule 4(d), there are no actions,  suits or proceedings  pending
or, to Sellers'  knowledge,  threatened  against KMD or  affecting  any of KMD's
properties or rights, at law or in equity, or before any federal,  state,  local
or other Governmental Body that could materially  adversely affect the Business,
the transactions  contemplated hereby or Buyer's unencumbered  possession or use
of the Assets.

            (ii) Without limiting the generality of the foregoing:

                  (A) No Seller,  including  KMD,  nor any of their  Principals,
officers,  directors,  partners,  managers, Members, nor, to Sellers' knowledge,
any of their  employees  or  agents,  has  engaged in any  activities  which are
prohibited,  or are cause for  restitution,  civil  penalties  or  mandatory  or
permissive exclusion from Medicare or Medicaid under Sections 1320a-7, 1320a-7a,
1320a-7b or 1395nn of Title 42 of the United States Code or otherwise  under the
authorities  of Sections  1128,  1156 or 1892 of the SSA,  the  federal  CHAMPUS
statute, or the regulations promulgated pursuant to such statutes or regulations
or  related  state or local  statutes  or which are  prohibited  by any  private
accrediting  organization from which Seller seeks  accreditation or by generally
recognized professional standards of care or conduct,  including but not limited
to the following activities:  (1) making or causing to be made a false statement
or  representation  of a material  fact in any  application  for any  benefit or
payment;  (2) making or causing to be made any false statement or representation
of a material fact for use in determining rights to any benefit or payment;  (3)
presenting or causing to be presented a claim for  reimbursement  under CHAMPUS,
Medicare, Medicaid or other State Health Care Program or any Federal Health Care
Program that is (x) for an item or service that the Person presenting or causing
to be  presented  knows or should know was not  provided as claimed,  (y) for an
item or service that the Person  presenting or causing to be presented  knows or
should know was not medically necessary,  or (z) for an item or service that the
Person presenting or causing to be presented knows or should know that the claim
is false or  fraudulent;  (4)  offering,  paying,  soliciting  or receiving  any
remuneration (including any kickback. bribe, or rebate), directly or indirectly,
overtly  or  covertly,  in cash or in kind (x) in return  for


                                       12
<PAGE>

referring,  or to induce  the  referral  of, an  individual  to a Person for the
furnishing  or  arranging  for the  furnishing  of any item or service for which
payment may be made in whole or in part by CHAMPUS,  Medicare  or  Medicaid,  or
State Health Care Program or any Federal  Health Care Program,  or (y) in return
for, or to induce,  the  purchase,  lease,  or order,  or the  arranging  for or
recommending of the purchase,  lease order, of any good,  facility,  service, or
item for which  payment  may be made in whole in part by  CHAMPUS,  Medicare  or
Medicaid or State Health Care Program or any Federal Health Care Program; or (5)
making or causing to be made or  inducing or seeking to induce the making of any
false statement or representation (or omitting to state a material fact required
to be stated therein or necessary to make the statements  contained  therein not
misleading)  or a material fact with respect to (x) the conditions or operations
of a Facility in order that the  Facility  may qualify  for  CHAMPUS,  Medicare,
Medicaid  or other  State  Health Care  Program or Federal  Health Care  Program
certification  or (y)  information  required  to be  provided  under SSA Section
1124A.

                  (B) Neither  KMD,  nor any Member,  nor any other  controlling
person,  Principal,  Member, manager,  partner, nor, to Sellers' knowledge,  any
employee or other agent of KMD or any of the  Sellers,  has had or has any civil
monetary  penalty assessed against it, him or her under SSA Section 1128A; is or
has been  excluded  from  participation  under the  Medicare  program or a State
Health Care Program; is or has been convicted (as that term is defined in 42 CFR
Section  1001.2) of any of the  categories of offenses  described in SSA Section
1128(a) and (b), including,  without limitation:  (I) criminal offenses relating
to the  delivery  of an item or service  under  Medicare,  Medicaid or any other
State  Health Care Program or any Federal  Health Care  Program;  (II)  criminal
offenses  under  federal or state law  relating  to patient  neglect or abuse in
connection  with the delivery of a health care item or service;  (III)  criminal
offenses  under  federal or state law  relating to fraud,  theft,  embezzlement,
breach of fiduciary responsibility,  or other financial misconduct in connection
with the delivery of a health care item or service or with respect to any act or
omission  in a  program  operated  by or  financed  in  whole  or in part by any
federal,  state or local government agency;  (IV) federal or state laws relating
to the interference with or obstruction of any  investigation  into any criminal
offense  described  in  subclauses  (I) through  (III)  above;  or (V)  criminal
offenses  under  federal  or state law  relating  to the  unlawful  manufacture,
distribution. prescription or dispensing of a controlled substance.

                   (C)  There  is  no  arrangement   relating  to  the  Business
providing for any rebates,  kickbacks or other forms of compensation  that could
be determined to be unlawful if paid to any Person in return for the referral of
business or for the  arrangement or  recommendation  of any referrals of testing
services.  All  billings  by KMD have  been  true and  correct  in all  material
respects and in compliance  with all  applicable  laws,  rules and  regulations.
There  are no  financial  or  compensation  relationships  between  any  Seller,
Affiliate  of a Seller or family  member of a Seller,  on the one hand,  and any
Person  who  refers,  or who is in a position  to  influence  referrals  of, any
Testing Services to KMD.

      (k) No  Adverse  Changes.  Except as set  forth on  Schedule  4(k),  since
December  31,  1998,  there has not been,  occurred or arisen:  (i) any material
change in any method of  accounting  or  accounting  practice  by KMD;  (ii) any
damage or  destruction  in the nature of a  casualty  loss,  whether  covered by
insurance  or not,  affecting  the Assets or which  might  otherwise  have or is
reasonably  likely to have a Material Adverse Effect on the Business;  (iii) any
increase in the  compensation  payable by KMD or to become payable by KMD to any
employee,  consultant or advisor of the Business,  except in the ordinary course
of business consistent with past practice;  (iv) any actual or threatened strike
relating to the Business or any unionization  activity with respect thereto; (v)
any  extraordinary  item (as defined by GAAP from time to time)  resulting  in a
loss suffered by the Business which, individually or in the aggregate, has or is
reasonably  likely  to have a  Material  Adverse  Effect;  (vi)  any  waiver  or


                                       13
<PAGE>

relinquishment  by KMD of any right or rights  (under  Contracts  or  otherwise)
relating to the Business  which,  individually  or in the  aggregate,  has or is
reasonably  likely to have a Material  Adverse  Effect,  or any  cancellation or
compromise of any Receivable,  debt or claim, or any waiver or settlement of any
legal  proceeding;  (vii) any mortgage on, pledge of or grant of a material Lien
or option on any of the Assets of the Business;  (viii) any obligation  incurred
by KMD other than any  incurred  in the  ordinary  course of  business or which,
individually or in the aggregate,  with all other obligations so incurred, is or
are not  material  in  amount  to KMD,  or any  commitment  to make any  capital
expenditures   or  capital   additions  or  betterments  in  excess  of  $10,000
individually  or $50,000 in the  aggregate;  (ix) any adoption,  entering  into,
amendment, alteration or termination partially or completely of any Benefit Plan
or compensation  arrangement  relating to or affecting any Principal,  director,
officer,  partner,  manager,  employee, agent or other similar representative of
KMD; (x) any Contract with any Principal,  director,  officer, partner, manager,
or  any  material   Contract   with  any   employee,   agent  or  other  similar
representative,  of KMD;  (xi) any  hiring of a  Principal,  director,  officer,
partner,  manager,  employee, agent or other similar representative of KMD whose
annual salary or wage exceeds $65,000;  (xii) any termination of a Contract that
is material to the Business or any indication  that any  third-party  intends to
terminate any such  Contract;  or (xiii) any other event,  condition or state of
facts  which has or could  reasonably  be  expected  to have a Material  Adverse
Effect.

      (l)  Intellectual  Property.  (i)  Schedule  4(l)  contains a complete and
accurate list of all material  Intellectual Property Rights owned or licensed by
KMD (other than  Intellectual  Property  Rights  relating to publicly  available
software used by KMD as an end-user in the  administration  and operation of the
Business),  specifying  as to  each,  as  applicable:  (A)  the  nature  of such
Intellectual  Property  Right and the  jurisdictions  in which  such  rights are
registered; (B) the owner of each Intellectual Property Right licensed by Seller
and  description  of any  royalty,  license or other fee  arrangements  relating
thereto;  (C) the  expiration  or  termination  date of each  license  or  other
Contract under which KMD is licensed or otherwise authorized to copy, reproduce,
market,  distribute,  prepare  derivative  works  based  on,  make,  use or sell
products  or  services  incorporating  the  subject  matter of any  Intellectual
Property  Rights owned by third Persons  ("Third  Party  Licenses ), and (D) any
third Person to whom any Intellectual  Property Right is licensed or sublicensed
by KMD.  Each of the  Intellectual  Property  Rights  shown  as  owned by KMD on
Schedule 4(1) is owned by KMD free and clear of material Liens. All of the Third
Party  Licenses  are valid,  enforceable  and in full force and effect,  and the
interests of KMD under such Third Party  Licenses are held free and clear of any
material  Liens.  Except  pursuant  to the  Third  Party  Licenses  set forth on
Schedule 4(1), KMD has no obligation to make any royalty or other payment to any
Person in connection with the use of or right to use any  Intellectual  Property
Right.  The  Intellectual  Property Rights owned by KMD as set forth on Schedule
4(1)  together  with  the  interests  of KMD  under  the  Third  Party  Licenses
(collectively,  the "KMD Intellectual  Property  Rights")  constitute all of the
Intellectual  Property Rights necessary for the conduct of the Business as it is
currently conducted.

            (ii) (A) To the  knowledge  of Sellers,  KMD  Intellectual  Property
Rights  do not  infringe.  violate  or  conflict  with any  patent  or any other
Intellectual  Property  Rights  of any  other  Person  and KMD  has  not  been a
defendant in any action, suit,  investigation or proceeding relating to, and has
not been notified of, any alleged claim of  infringement,  violation or conflict
as to any  Intellectual  Property  Rights,  and  there  has not  been  any  such
infringement or violation by KMD; (B) to Sellers' knowledge, except as set forth
on Schedule 4(l), there has not been any infringement by any other Person of any
KMD  Intellectual  Property  Rights  which are  material  to the  conduct of the
Business;  (C) to the knowledge of Sellers,  no KMD Intellectual  Property Right
which is material to the conduct of the  Business is subject to any  outstanding
judgment,  injunction, order, decree or agreement restricting the use thereof by
KMD or 


                                       14
<PAGE>

restricting  the  licensing  thereof  by or to any  Person;  and (D) KMD has not
entered into any Contract to  indemnify  any other Person  against any charge of
infringement of any Intellectual Property Right.

            (iii) To Sellers' knowledge,  the source codes of KMD do not contain
any back door, time bomb, drop dead device or other software routine designed to
disable a computer  program,  or any virus,  worm or other software  routines or
hardware components designed to permit unauthorized access, to disable, erase or
otherwise  harm  software,  hardware or data,  or to perform  any other  similar
actions.

      (m)    Certain Transactions, Customers and Suppliers.

            (i) Except as set forth on Schedule 4(m)(i) and Contracts  involving
payments  of not more  than $500 per  month  and not more  than  $30,000  in the
aggregate and Contracts  terminable without penalty on less than thirty-one (31)
days  notice,   there  are  no  Contracts,   leases  or  business  or  financial
arrangements  involving  or  affecting  the  Business,   properties,  Assets  or
operations of KMD between, on the one hand, KMD, and, on the other hand, (A) any
Member,  Principal,  officer,  director,  partner,  manager,  employee  or other
Affiliate  of KMD,  or (B) any  immediate  family  member or  Affiliates  of any
Member, Principal, officer, director, partner, manager or employee of KMD or its
any Affiliate.

            (ii) Schedule 4(m)(ii) lists the top ten customers and suppliers (in
terms of dollar value of goods and/or  services  purchased  from or furnished to
KMD)  for  each  of  the  past  two  completed  fiscal  years  and  the  current
year-to-date. Except as described on Schedule 4(m)ii), none of such customers or
suppliers has indicated to KMD that it intends to decrease the level of business
currently conducted with KMD. Except as disclosed on Schedule 4(m)(ii),  neither
any  Seller  nor any  Member,  Principal,  or  manager  of KMD nor any of  their
respective Affiliates,  officers,  directors,  partners, employees or agents has
any direct or  indirect  interest  in any such  customer  or  supplier or in any
competitor of the Business.

      (n) Pension and  Benefit  Plans.  (i)  Schedule  4(n) sets forth:  (A) all
current  "employee  benefit  plans," as defined in Section 3(3) of ERISA and (B)
all actual or ad hoc, as the case may be,  severance  pay, sick leave,  vacation
pay, salary  continuation,  disability,  deferred  compensation,  bonus or other
incentive   compensation,   stock  purchase,   life  insurance  and  educational
assistance policies, programs or arrangements,  pursuant to which KMD could have
any obligation or liability, contingent or otherwise (the "Benefit Plans"). None
of the Benefit Plans is a  "multiemployer  plan", as defined in Section 3(37) of
ERISA  ("Multiemployer  Plan"),  or has been subject to Sections 4063 or 4064 of
ERISA ("Multiple Employer Plans").

            (ii) True,  correct and complete  copies of the following  documents
with respect to each of the Benefit Plans have been  delivered or made available
to Buyer: (A) any plans and related trust documents, and amendments thereto; (B)
the most recent Form 5500; (C) the last IRS  determination  letter;  (D) summary
plan descriptions.  To Sellers'  knowledge,  there are no actuarial reports with
respect to any of the Benefit Plans,  including an actuarial  report relating to
post-employment benefits.

            (iii) The Benefit Plans intended to qualify under Section 401 of the
Code and the trusts  maintained  pursuant thereto are in substantial  compliance
with ERISA.  Each Benefit Plan which is intended to be qualified  under  Section
401(a)  of the Code has  received  a  favorable  determination  letter  from the
Internal Revenue  Service,  or such plan was established by adopting a prototype
plan which has received a favorable  opinion  letter from the  Internal  Revenue
Service and the Internal Revenue Service has not taken any action to revoke such
letter,  the adoption  agreement was a standard  adoption  agreement  creating a
standardized plan, and KMD has done nothing, and to Sellers' knowledge,  nothing
has 


                                       15
<PAGE>

occurred  with  respect to the  operation  of any such plan which could create a
material risk of the loss of such  qualification  or exemption or the imposition
of any material liability, penalty or tax under ERISA or the Code.

            (iv) All  contributions  (including all employer  contributions  and
employee salary reduction contributions) and payments required to have been made
under any of the Benefit Plans or by law (without  regard to any waivers granted
under  Section  412 of the  Code),  have  been  made  by the due  date  therefor
(including any valid extension),  except where failure to do so would not have a
Material Adverse Effect. No accumulated funding deficiencies exist in any of the
Benefit Plans subject to Section 412 of the Code.

            (v) There is no  substantial  violation of ERISA with respect to the
filing of applicable reports,  documents and notices regarding the Benefit Plans
with the Secretary of Labor and the Secretary of the Treasury or the  furnishing
of such  documents to the  participants  or  beneficiaries  of the Benefit Plans
which would have a material adverse effect.

            (vi)  The  Benefit  Plans  have  been  maintained  and  operated  in
substantial  compliance  with their terms and with all  provisions  of ERISA and
other  applicable  federal  and  state  laws  and  neither  KMD  nor  any of its
Affiliates has incurred any liability,  direct or indirect,  for any "prohibited
transaction"  within the  meaning of Section  4975 of the Code or Section 406 of
ERISA with  respect to any  Benefit  Plan  which  would have a material  adverse
effect.

            (vii)  Except  as set forth on  Schedule  4(n)(vii),  no Seller  has
received any notice (whether oral or written), nor is any Seller otherwise aware
of,  any  pending  actions,  claims or  lawsuits  which  have been  asserted  or
instituted against the Benefit Plans, the assets of any of the trusts under such
plans or the plan sponsor or the plan administrator, or against any fiduciary of
the Benefit Plans with respect to the  operation  such plans (other than routine
benefit  claims),  nor, to Sellers'  knowledge,  are there any facts which could
form the basis for any such claim or lawsuit.

            (viii) All  amendments  and  actions  required  to bring the Benefit
Plans  into  conformity  in all  material  respects  with all of the  applicable
provisions of ERISA and other  applicable laws have been made or taken except to
the extent that such amendments or actions are not required by law to be made or
taken until a date after the Closing Date.

            (ix) Except as  disclosed  in Schedule  4(n),  KMD does not maintain
Benefit  Plans which are  post-employment  medical or life  insurance  plans and
which provide for  continuing  benefits or coverage for any  participant  or any
beneficiary of a participant,  except as may be required under Part 6 of Title I
of ERISA and at the expense of the participant or the participant's  beneficiary
or which otherwise would not create a material liability for Buyer.

            (x) Except for Key Employees,  employees with an employment contract
with Buyer,  or as provided in  Subsections  6(e) and 7(c),  below,  neither the
execution  and  delivery  of  this  Agreement,   nor  the  consummation  of  the
transactions  contemplated  hereby,  will  change  the terms and  conditions  of
employment with respect to any individual or (A) result in any payment  becoming
due to any  employee  (current,  former or retired)  of KMD,  (B)  increase  any
benefits  payable under any Benefit Plan, (C) result in the  acceleration of the
time of payment or vesting of any such  benefits,  or (D)  restrict or otherwise
limit Buyer's  unrestricted  opportunity  to change the terms and  conditions of
employment with respect to any individual.


                                       16
<PAGE>

            (xi) KMD does not have any Contract, whether legally binding or not,
to create any additional employee benefit plan or to modify any existing Benefit
Plan.

      (o) Tax Matters. Except as set forth in Schedule 4(o):

            (i) KMD has timely filed all Tax Returns required to be filed by it,
such Tax Returns are  complete  and correct in all  material  respects,  and all
Taxes reported payable on such Tax Returns,  or claimed in writing by any taxing
authority  to be due,  have been timely paid or  provided  for in the  Financial
Statements  in  accordance  with GAAP.  KMD has not  incurred  any  material Tax
liability for its taxable year  beginning  January 1, 1999 other than in respect
of the  conduct of the  Business in the  ordinary  course.  With  respect to any
period up to the Closing Date for which Tax Returns have not yet been filed,  or
for which Taxes are not yet due or owing,  KMD has made (or, with respect to any
period  after the end of the most  recent  fiscal  quarter,  will  make) due and
sufficient  current  accruals  for any such  Taxes  owed by KMD in its books and
records in accordance  with GAAP.  KMD has delivered to Buyer true,  correct and
complete  copies of its federal and state  income Tax Returns for the  preceding
two  taxable  years.  There are no Liens  with  respect to Taxes upon any of the
Assets of KMD,  other  than Liens for Taxes  which are not yet due and  payable,
unless  such  Taxes are being  contested  in  accordance  with  applicable  law.
Schedule  4(o)  sets  forth a  description  of all such  Taxes  that  are  being
contested in accordance with applicable law.

            (ii) The Tax  Returns of KMD have not been  audited by the  Internal
Revenue Service (the "IRS") or by any state or local taxing  authorities  within
the two year period prior to the Closing.  There are no outstanding  agreements,
waivers, or arrangements extending the statutory period of limitation applicable
to any claim for, or the period for the  collection or assessment  of, Taxes due
from or  with  respect  to KMD for any  taxable  period.  No  closing  agreement
pursuant to Section 7122 of the Code or  compromise  pursuant to Section 7122 of
the Code (or any predecessor  provision) or any similar  provision of any state,
local, or foreign law has been entered into by KMD. No audit or other proceeding
by any  court,  governmental  or  regulatory  authority  is  pending  or, to the
knowledge  of any Seller,  threatened  with respect to any Taxes due from KMD or
any Tax Return filed by KMD. No assessment of Tax is proposed against KMD or any
of its Assets.

            (iii) All  elections  made or filed by KMD with respect to Taxes are
set  forth  on  Schedule  4(o)(iv).  None of the  Assets  of KMD is an  asset or
property  that is or will be  required  to be  treated as being (A) owned by any
person other than KMD  pursuant to the  provisions  of Section  l68(f)(8) of the
Internal  Revenue Code of 1986 as amended and in effect  immediately  before the
enactment of the Tax Reform Act of 1986, or (B) "tax-exempt use property" within
the meaning of Section  168(h)(l ) of the Code.  KMD has not agreed to nor is it
required to make any  adjustment  pursuant to Section 481(a) of the Code (or any
predecessor  provision) by reason of any change in any accounting method;  there
is no application  pending with any taxing authority  requesting  permission for
any changes in any accounting method; and, to the knowledge of Sellers,  the IRS
has not proposed any such adjustment or change in accounting method.

            (iv) KMD is not and has not been in violation  (and,  with notice or
lapse of time or both, would not be in violation) of any applicable law relating
to the payment or  withholding of Taxes.  KMD has duly and timely  withheld from
employee  salaries,   wages,  and  other  compensation  and  paid  over  to  the
appropriate  taxing  authorities all amounts required to be so withheld and paid
over for all periods under all applicable laws.


                                       17
<PAGE>

            (v) KMD is not a party to, is not  bound  by,  and is not  obligated
under, any Tax sharing agreement or similar Contract or arrangement. There is no
Contract,  plan  or  arrangement  covering  any  Person  that,  individually  or
collectively,  could give rise to the  payment  of any amount  that would not be
deductible by KMD by reason of Section 280G of the Code.

      (p) Material Contracts. Except as set forth on Schedule 4(p), KMD is not a
party to or bound  by any (A)  material  Contract  with  any  hospital,  clinic,
physician,   health  or   medical   insurance   provider,   health   maintenance
organization, group health or managed care plan, preferred provider organization
or similar  organization;  (B) Contract requiring any Person to purchase,  sell,
provide  or refer all or a fixed  portion of its  output,  produce  services  or
requirements from or to another Person; (C) Contract involving the commitment to
pay, or to acquire or to provide, goods or services with a fair market value, in
excess of $50,000,  provided  that such Contract does not extend for a period of
more than one year beyond the Closing  Date;  (D)  partnership  or joint venture
Contract; (E) Contract for the acquisition,  sale or lease of any Assets of KMD;
(F) mortgage, pledge, conditional sales contract, security agreement,  factoring
agreement or other similar Contract with respect to any material real,  tangible
or  intangible  personal  property of KMD; (G) material loan  agreement,  credit
agreement, promissory note, guarantee, subordination agreement, letter of credit
or any other  similar type of Contract of KMD or the Members with respect to the
Business;   (H)  exclusive   retainer  Contract  with  attorneys,   accountants,
actuaries,  appraisers or other professional  advisers; (I) Contract that limits
the  freedom of KMD to compete in any line of  business or with any Person or in
any area; (J) employment, severance or golden parachute Contract or any Contract
which has, as a principal  purpose,  the  provision  of  indemnification  to any
Person;  and (K) other  Contract  material  to the  Business,  the Assets or the
Assumed Obligations.  KMD has made available to Buyer true, correct and complete
copies of each Contract  listed on Schedule 4(p),  together with all amendments,
modifications,  supplements  or side letters  affecting the  obligations  of any
party thereunder. Schedule 4(p) indicates which Contracts require the consent of
another Person to the assignment thereof to Buyer pursuant to this Agreement. To
Sellers'  knowledge,  each of the Contracts listed on Schedule 4(p) is valid and
enforceable in accordance with its terms, subject to' applicable  bankruptcy and
similar laws affecting  creditors' rights and remedies generally and subject, as
to enforceability,  to general  principles of equity.  There is no default under
any Contract  listed on such Schedule by KMD or, to Sellers'  knowledge,  by any
other party thereto, and to the knowledge of Sellers, no event has occurred that
with the lapse of time or the  giving of  notice,  or both  would  constitute  a
default thereunder, except in each case to the extent that such default does not
or would not have a material  adverse effect on the rights or obligations of the
parties  under such  Contract;  and no  previous  or  current  party to any such
Contract  has given to KMD notice of or made a claim with  respect to any actual
or alleged  breach or default  thereunder or of such party's intent to terminate
or not renew any Contract .

      (q) Insurance.  Schedule 4(q) sets forth a list of all insurance  policies
and other  surety  arrangements  of any kind or nature  whatsoever  which are in
force and to which KMD is a named party or beneficiary,  specifying the carrier,
and the type and limits of insurance coverage thereunder.  KMD has complied with
the material  requirements  of each such policy and is current in the payment of
all premiums with respect thereto.

      (r) Labor  Matters.  Schedule 4(r) sets forth a list  containing the name,
position and date of employment of each employee of KMD as of the date hereof (a
"KMD Employee"). A list setting forth each KMD Employee's current base salary or
wage rate (and commission or bonus schedule) has been delivered by KMD to Buyer.
KMD is not party to any labor or collective bargaining agreement,  and there are
no labor or collective  bargaining agreements which pertain to any KMD Employee.
No labor


                                       18
<PAGE>

organization  has made a pending demand for  recognition or, to the knowledge of
Sellers,  has filed a  petition  seeking a  representation  proceeding  which is
presently pending before the National Labor Relations Board. Except as disclosed
on Schedule 4(r), there are no complaints, charges or claims against KMD pending
or  threatened  to be  brought  or filed  with any  Governmental  Body based on,
arising out of, in connection with, or otherwise  relating to, the employment or
termination  of  employment  of any KMD Employee by KMD.  KMD is in  substantial
compliance  with the  provisions of the  Occupational  Safety and Health Act and
WARN,  and all other  federal,  state and local  laws,  regulations  and  orders
relating to the employment of labor,  including all such laws,  regulations  and
orders relating to wages, hours,  collective bargaining,  discrimination,  civil
rights, safety and health,  workers' compensation and the collection and payment
of  withholding  and/or social  security  taxes and any similar tax,  except for
immaterial non-compliance.

      (s) Personal Property. KMD has made available to Buyer a true and complete
list of all tangible  assets (or categories  thereof)  reflected on the December
31, 1998 balance  sheet and all items  thereof are in good working and operating
condition  (normal wear and tear excepted) and have been properly  maintained in
accordance  with  the   manufacturers'   specifications  and  accepted  industry
practices.  Since December 31, 1998, KMD has not disposed of any tangible assets
(other than de minimis  tangible  assets)  reflected  on the  December  31, 1998
balance sheet other than  expendable  supplies and through the sale of inventory
in the ordinary course of the Business.  KMD does not hold any personal property
of any Person pursuant to any consignment or similar arrangement .

      (t) Title to and  Sufficiency  of Assets.  (i) KMD holds and owns good and
marketable  title to and has an  unrestricted  right to transfer title to all of
the tangible assets being transferred to Buyer hereunder (including the Assets),
in each  case  free and  clear  of any  material  Lien,  other  than  (A)  Liens
specifically  described in the  December 31, 1998 balance  sheet or noted on any
Schedule  hereto and (B) assets  leased by KMD as  described in the December 31,
1998 balance sheet or any Schedule  hereto;  (ii) The Assets,  together with the
Lease, are sufficient for the continued  operation by Buyer of the Business from
and after the Closing in substantially  the same manner as conducted on the date
hereof.

      (u) The Facilities.  To Sellers'  knowledge,  KMD has all  certificates of
occupancy and permits of any Governmental Body necessary for the current use and
operation of the Facilities,  and KMD has complied with all material  conditions
of such permits.

      (v) Brokers and Finders.  No broker,  investment banker or finder has been
retained  by or  authorized  to act on behalf of KMD or any  Member who might be
entitled  to any fee or other  commission  in  connection  with the  Acquisition
Documents and the transactions contemplated thereby.

      (w) Year 2000 Compliance. KMD has (i) initiated a review and assessment of
all areas within its  businesses  and  operations  (including  those affected by
suppliers,  vendors and customers) that could be adversely affected by a failure
to be Year 2000 Compliant (as defined below), (ii) developed a plan and timeline
for  addressing  Year  2000  Compliance  on a timely  basis,  and (iii) to date,
implemented  that plan in accordance  with that  timetable,  all as described on
Schedule  4(w).  All computer  applications  (including  those of its suppliers,
vendors and  customers)  that are material to the Business are, to the knowledge
of  Sellers,  except as set forth on  Schedule  4(w),  reasonably  expected on a
timely basis to be Year 2000 Compliant.

          For purposes of this Agreement, "Year 2000 Compliant" means that KMD's
systems are designed to be used prior to,  during and after  calendar  year 2000
A.D. and, except for errors, 


                                       19
<PAGE>

malfunctions,  inaccuracies and failures due solely to  non-compliant  hardware,
software,  networks  or data  owned or  controlled  by third  parties,  will (i)
operate  normally,  (ii)  record  dates  properly,  (iii)  accurately  determine
intervals  between and time elapsed  among dates  before,  within and after such
year  and  (iv)  otherwise   operate   without  error  relating  to  date  data,
specifically including any error relating to, or the product of, date data which
represents or references  different centuries or more than one century.  Without
limiting the foregoing, "Year 2000 Compliant" means that KMD's systems:

            (i)  will  not  abnormally   terminate  or  stop   processing   upon
encountering date data either from before, within or after such year;

            (ii) will  properly  identify  leap years and process  related  date
data;

            (iii) have been designed to ensure Year 2000 Compliance,  including,
without limitation, recognizing and recording the proper century associated with
date data and properly  calculating same century and multi-century  formulas and
date values;

            (iv) include  user  interfaces  that  properly  display,  record and
accept date data in single century and multi-century cases;

            (v)  properly  send  date  data to,  and  receive  date  data  from,
hardware,  software  and  systems  with which  KMD's  systems  would be normally
operated,  including  on-site backup,  hot-site  companion and disaster recovery
systems,  as well as properly  recording,  retaining and manipulating  such date
data; and

      (x) Medicare Provider Numbers.  KMD has only one Medicare provider number,
which is L220810.

      (y) Testing Services.  There are no known,  anticipated or suspected fixed
or  contingent  material  liabilities  with  respect  to  any  of  the  anatomic
pathology,  surgical pathology or clinical  laboratory testing services provided
by KMD that have not been disclosed to Buyer.

      (z) No Misrepresentation.  No representation or warranty of KMD or Sellers
contained in this Agreement  contains any untrue statement of a material fact or
omits to state a material fact necessary to make the statements contained herein
or therein not misleading.

      (Aa)  Acquisition  for  Investment.   KMD  is  acquiring  the  Shares  for
investment  for its own  account  and not with a view to,  or for the  resale in
connection with, the distribution  thereof in violation of the Securities Act of
1933, as amended.  KMD  acknowledges  that it has been advised by Buyer that (i)
the Shares have not been registered  under the Act or the securities laws of any
state  and are  being  offered  and  sold in  reliance  on  exemptions  from the
registration  requirements  of the Securities Act and such laws; (ii) the Shares
are  subject  to  restrictions  on  transferability  and  resale  and may not be
transferred or resold except as permitted under the Securities Act and such laws
pursuant to registration or exemption therefrom;  and (iii) a restrictive legend
will be placed on the certificates representing the Shares.

      5.  REPRESENTATIONS  AND WARRANTIES OF BUYER.  Buyer hereby represents and
warrants  to KMD as  follows  and  acknowledges  that  KMD is  relying  on  such
representations and warranties in connection with the transactions  provided for
herein:


                                       20
<PAGE>

      (a) Organization.  Etc. Buyer is a corporation duly incorporated,  validly
existing  and in good  standing  under the laws of the State of Delaware and has
all requisite corporate power and authority to (i) conduct its business as it is
now conducted, (ii) enter into and perform its obligations under the Acquisition
Documents and (iii)consummate the transactions  contemplated  thereby.  Buyer is
duly qualified and is in good standing in each jurisdiction  where the nature of
its business  makes such  qualification  necessary.  True,  correct and complete
copies of the Certificate of  Incorporation  and By-Laws of Buyer (together with
all amendments thereto and restatements thereof as of the date hereof) have been
previously delivered to KMD.

       (b) Authorization; Execution; Binding Effect. The execution, delivery and
performance  of  the   Acquisition   Documents  and  the   consummation  of  the
transactions provided for therein have been, or will as of the Closing Date have
been,  duly authorized by all necessary  corporate  action on the part of Buyer.
This  Agreement has been,  and the other  Acquisition  Documents will at Closing
have been,  duly and validly  executed and  delivered by Buyer and (assuming the
due  authorization,  execution and delivery  thereof by KMD and the Members) the
Acquisition  Documents  constitute  the legal,  valid and binding  obligation of
Buyer  enforceable  against  Buyer in  accordance  with their  terms,  except as
enforceability may be limited by bankruptcy, insolvency, reorganization or other
laws affecting creditors rights and remedies generally and by general principles
of  equity  (regardless  of  whether  such  enforceability  is  considered  in a
proceeding  in  equity  or at  law).  No  approval,  consent  or  authorization,
including any action,  approval,  consent or  authorization of any kind from any
governmental  entity or  instrumentality is necessary or required as to Buyer in
order to constitute  this  Agreement as a valid and binding  obligation of Buyer
enforceable in accordance  with its terms.  Notwithstanding  the foregoing,  the
parties  are aware that  audited  financial  statements  of KMD must be filed by
Buyer with the SEC within  seventy-five  (75) days after the Closing and that an
SEC Form 8-K filing for disclosing  material events must be made by Buyer within
fifteen (15) days after the Closing.

      (c) No  Conflicting  Agreements  or  Charter  Provisions.  The  execution,
delivery and compliance  with and performance of the terms and provisions of the
Acquisition  Documents will not conflict with or result in a material  breach of
the terms,  conditions or provisions of, or constitute a material default (or an
event which,  with notice,  lapse of time, or both,  would constitute a material
default) under,  or result in any material  violation of, or require the consent
of any Person under (i) the Certificate of  Incorporation or By-Laws of Buyer or
any resolutions  adopted by the Board of Directors of Buyer,  (ii) any provision
of any  Contract to which Buyer is a party or by which any property of Buyer may
be bound,  (iii) any order,  judgment,  decree,  permit,  statute,  law, rule or
regulation of any Governmental Body to which Buyer is subject or by which any of
its properties or assets is bound. No consent, waiver,  approval,  order, permit
or  authorization  of, or  declaration  or filing with, or  notification  to any
Person or Governmental  Body is required on the part of Buyer in connection with
the execution  and delivery of the  Acquisition  Documents or the  compliance by
Buyer with any of the provisions thereof, except for those already obtained.

      (d) Brokers and Finders.  No broker,  investment banker or finder has been
retained  or  authorized  to act on behalf of Buyer who might be entitled to any
fee or other  commission in connection  with the  Acquisition  Documents and the
transactions contemplated thereby .

      (e) No Misrepresentation. No representation or warranty of Buyer contained
in this Agreement  contains any untrue  statement of a material fact or omits to
state a material  fact  necessary  to make the  statements  contained  herein or
therein not misleading.


                                       21
<PAGE>

      (f) Litigation.  Except as set forth in Schedule 5(f), there is no action,
suit, proceeding or investigation  pending, or, to the actual knowledge of Buyer
after  diligent  inquiry,  threatened,  at law or in  equity,  in or before  any
Governmental  Body (i) to which Buyer is a party or by which any of its material
properties or material assets is bound, (ii) against any employee or director of
Buyer  in  connection  with its  business,  or (iii)  questioning  or  otherwise
affecting the validity of the Acquisition Documents or any action taken or to be
taken pursuant to or in connection with the Acquisition Documents.

      (g)  Capitalization,  Options or Other Rights. The authorized,  issued and
outstanding  capital stock of the Company,  including  any warrants,  options or
other  rights to acquire such capital  stock,  is as set forth on Schedule  5(g)
hereto. All of such shares of capital stock set forth on such schedule as issued
and outstanding have been duly authorized and validly issued, are fully paid and
nonassessable  and have not been issued in material  violation of any federal or
state  securities laws or any preemptive  rights of third parties.  When issued,
the  Shares  will  be  duly  authorized  and  validly  issued,  fully  paid  and
nonassessable  and, assuming the accuracy of the applicable  representations  of
Sellers in the  Registrations  Rights  Agreement,  will not have been  issued in
violation of any applicable  federal or state  securities laws or any preemptive
rights of third  parties.  Except for stock  options of eligible  employees  and
directors of Buyer and as  otherwise  set forth in Schedule  5(g),  there are no
current commitments,  plans or arrangements to issue or sell, and no outstanding
options,  warrants,  convertible  securities  or other  rights  calling  for the
issuance of,  additional  shares of the capital stock or other equity securities
of Buyer.

      (h) After  diligent  inquiry,  Buyer is  unaware of any  actions  taken or
conduct  engaged in by it that would  preclude  Buyer from lawfully  operating a
laboratory in accordance with the laws of the State of New York.

      (i) SEC Reports. Buyer has delivered to KMD the Annual Report on Form 10-K
for the fiscal year ended December 31, 1998 and the proxy statement with respect
to the 1999 Annual Meeting of Shareholders (collectively, the "SEC Reports"). At
the time of their filing, the SEC Reports complied in all material respects with
the applicable  requirements  of the Exchange Act and did not contain any untrue
statement of a material  fact or omit to state any material  fact required to be
stated  therein or necessary in order to make the  statements  made, in light of
the circumstances under which they were being made therein, not misleading.

      6.  COVENANTS OF KMD.

      (a) Conduct of Business.  From and after the date hereof until the Closing
Date, KMD shall (i) conduct its business in the ordinary course, consistent with
the present conduct of the Business,  (ii) use reasonable  commercial efforts to
maintain,  preserve and protect the Assets and good-will of the Business,  (iii)
use  reasonable  commercial  efforts to keep  available  the services of present
employees,  (iv) use reasonable commercial efforts to preserve its relationships
with all  customers,  suppliers and others doing business with it, (v) not merge
or consolidate  with any other Person or acquire a material  amount of assets or
securities of another Person, (vi) not sell, license or otherwise dispose of, or
grant  any Lien or option  on or  otherwise  encumber,  any  material  assets or
property,  (vii) not take any  action  that  would  make any  representation  or
warranty of Seller hereunder inaccurate in any material respect at, or as of any
time prior to, the Closing Date  (including any action of the types described in
Section 4(k)),  and not enter into or amend any material  Contract or consent to
any judgment or settlement,  in each case relating to or affecting the Business,
the Assets or the Assumed  Obligations,  in each case,  without Buyer's specific
prior  written  consent  and  (viii)  not  agree or  commit  to take any  action
inconsistent with its obligations under clauses (i) through (vii) above.


                                       22
<PAGE>

      (b) Access to Documents;  Opportunity to Ask Questions. From and after the
date hereof, KMD will continue to make available for inspection by Buyer and its
duly authorized  representatives,  during normal  business hours,  the corporate
records,  books of account,  Contracts,  reports and all other  documents  of or
relating to KMD,  the  Business,  the Assets,  the  Assumed  Obligations  or the
Facilities which are reasonably  requested by Buyer or such  representatives  to
make  reasonable  inspection and  examination of the Business,  the Assets,  the
Assumed  Obligations  and the affairs of KMD. KMD has and will continue to cause
its  managerial  employees,  counsel and regular  independent  certified  public
accountants to be available  during normal  business  hours and upon  reasonable
notice to answer  questions  of Buyer  and its duly  authorized  representatives
concerning  the  business,  assets  and  affairs  of  KMD,  including,   without
limitation,  the ongoing audit of KMD being  conducted at the direction of Buyer
for purposes of its required filing with the SEC. Any investigations carried out
by Buyer or its  authorized  representatives  shall not affect or mitigate KMD's
covenants,  representations  and warranties  hereunder,  which shall continue in
full force and effect.

      (c) Regulatory Approvals and Other Consents.  KMD shall use its reasonable
commercial efforts to obtain any and all governmental and third-party approvals,
consents, certifications and waivers (and will provide copies thereof and of all
correspondence  with respect thereto,  to Buyer) required in connection with the
transactions  contemplated by the Acquisition Documents,  and KMD shall make all
filings required in connection therewith as promptly as practicable.

      (d) Reasonable Commercial Efforts. KMD shall use its reasonable commercial
efforts to satisfy the conditions  precedent to the  performance by Buyer of its
obligations under this Agreement.

      (e) Employee  Obligations.  Except for the Key Persons and those employees
of KMD  subject  to an  Employment  Agreement  hereunder,  Buyer  shall  have no
obligation to hire any employees of KMD. Notwithstanding the foregoing,  Sellers
shall not interfere with Buyer's hiring of any KMD employee. Except as expressly
provided in Section 7(c) below,  KMD shall be solely  responsible  for and shall
pay all accrued and unpaid salaries,  wages, vacation and sick pay to all of its
employees,  including those hired by Buyer, and shall be solely  responsible for
any severance pay and benefits  required to be paid or extended to KMD employees
not  hired by Buyer.  KMD  shall  continue  to  employ  at will  those  billing,
collections  and other  personnel  listed on  Schedule  6(e) hereto and shall be
solely responsible for them. KMD shall comply with all federal,  state and local
laws with respect to the termination of its employees. All commissions earned by
sales and  marketing  representatives  of KMD through the Closing  Date shall be
paid by KMD within sixty (60) days after the Closing Date.

      Except as explicitly  provided otherwise in this Agreement,  KMD employees
hired by Buyer shall be subject to the policies of Buyer applicable to its other
employees and shall be eligible for benefits  only under  Buyer's  benefit plans
and policies,  all in accordance with their terms,  conditions and requirements,
including,  without limitation,  eligibility requirements based upon the date of
hire by Buyer.

      7.   COVENANTS OF BUYER.

      (a)  Cooperation  with KMD;  Reasonable  Commercial  Efforts.  Buyer shall
cooperate with KMD in connection  with the KMD's  fulfillment of KMD's covenants
and agreements set forth in Section 6, and in connection therewith,  Buyer shall
furnish KMD with such information as is reasonably requested by KMD with respect
to the  transaction  contemplated  thereby,  and Buyer shall use its  


                                       23
<PAGE>

reasonable  commercial  efforts  to  satisfy  the  conditions  precedent  to the
performance by KMD of its obligations under this Agreement.

      (b)  Regulatory  Approvals  and  Other  Consents.   Buyer  shall  use  its
reasonable commercial efforts to obtain any and all governmental and third-party
approvals, consents, certifications and waivers (and will provide copies of such
notices to KMD) required in connection with the transactions contemplated by the
Acquisition  Documents,  and Buyer shall make all filings required in connection
therewith as promptly as possible.

       (c)  Hiring  of KMD  Employees.  Except  for the Key  Persons  and  those
employees of KMD subject to an Employment Agreement hereunder,  Buyer shall have
no  obligation  to hire any  employees  of KMD and Buyer shall have the right to
hire any of the  employees  of KMD that it chooses  (other than those  employees
listed on Schedule 6(e)),  which employment shall be on the terms and conditions
and  for the  compensation  determined  by  Buyer  and  such  employee.  For KMD
employees  hired by Buyer and  terminated  within one hundred  twenty (120) days
after the Closing Date,  KMD shall pay all accrued and unpaid  vacation and sick
pay through the date of termination  and Buyer shall pay such severance as would
be required  under its severance  policy had such persons been hired by Buyer on
their original date of hire by KMD, Kyto or Meridien. For KMD employees hired by
Buyer and  terminated  after one hundred twenty (120) days following the Closing
Date,  Buyer shall pay all accrued and unpaid  vacation and sick pay through the
date of  termination,  as well as such  severance as would be required under its
severance  policy had such persons been hired by Buyer on their original date of
hire by KMD, and, for such employees,  Buyer shall be responsible for payment of
all  contributions  required under  employment  insurance,  social  security and
income tax laws.

       Buyer shall  permit KMD  employees  hired by Buyer to carry into 1999 any
unused  vacation  time  that has  accrued  since  such  employee's  most  recent
anniversary of the date of his or her hire by KMD,  provided that such allowance
shall not exceed four weeks of  vacation  time for any  employee  and no accrued
vacation time shall be carried over into the year 2000. Beginning on the Closing
Date,  KMD  employees  hired  by Buyer  shall be  subject  to  Buyer's  policies
regarding vacation time and accrual and shall not be permitted to carry over any
accrued and unused vacation time from year-to-year, except as expressly provided
herein or by Buyer's  policies.  Except as limited above,  Buyer shall determine
vacation  benefits by reference to the former KMD  employees'  original  date of
hire by KMD, Kyto or Meridien.

            (d)   Recordkeeping.   Buyer  shall  maintain  reports  and  records
delivered  to it by KMD under  Section  2(f) above for such time  periods as are
specified by Title 10,  Subpart  58-1,  Section  58-1.11 of the New York Code of
Rules and Regulations, as the same may be amended from time to time, and, during
such  retention  periods,  shall make the same  reasonably  accessible to KMD as
required  for  audit  purposes  or for  verifying  Buyer's  compliance  with its
obligation  under Section 3(c) above.  For a period of five years from and after
the Closing Date or for such longer period as is required by law with respect to
the retention of such slides,  specimens and records, Buyer shall, after receipt
of a request or demand for  pathology or cytology  slides,  specimens or medical
records  pertaining to medical  examinations  conducted in the pre-Closing  time
period,  notify  Richart  of such  request  or  demand  and  provide  him with a
reasonable  opportunity  to review the same on site at DIANON prior to notifying
or granting access to any other person or persons (except where required by law)
in accordance  with  DIANON's  protocols  for the  preservation  of such slides,
specimens  and  records.  DIANON  shall  lawfully  dispose  of all such  slides,
specimens and records upon the  termination  of the applicable  legal  retention
period.


                                       24
<PAGE>

      (e) Software  License.  Buyer shall, and hereby does,  effective as of the
Closing  Date,  to the full extent  permitted  by the right,  title and interest
acquired  in the same by Buyer at the  Closing,  grant to  Richart a  perpetual,
world-wide, royalty-free license to make, have made, use and sell the laboratory
and billing software currently in use in the KMD New City Facility.

      8. MUTUAL  CONDITIONS TO THE OBLIGATIONS OF BUYER AND KMD. The obligations
of Buyer and KMD to consummate the Closing are subject to the  satisfaction,  on
or prior to the Closing Date, of the following  conditions,  any or all of which
may be waived in writing by the party entitled to waive such condition;

      (a) No  Prohibition.  No provision of any applicable law or regulation and
no  judgment,  injunction,  order or decree shall  restrain,  prohibit or impose
substantial damages with respect to the consummation of the Closing.

      (b) Government  Approval.  All actions by or in respect of or filings with
any  Governmental  Body required to permit the  consummation  of the transaction
contemplated herein shall have been taken or made.

      (c) Employment  Agreements.  Richart, Beth Phillips and Dana Shapiro shall
have entered into their respective  Employment Agreements with Buyer as provided
in EXHIBIT B.

      (d) Consulting  Agreement.  Shapiro shall have entered into the Consulting
Agreement with Buyer provided in EXHIBIT A.

      (e) Lease.  Buyer and lessor shall have entered into the Lease as provided
in EXHIBIT C and Sellers shall have obtained the lessor's consent to assignment,
and Buyer shall have entered into, the lease of the Woodbury Facility.

      (f)  Absence  of  Proceedings.  No action or  proceeding  shall  have been
instituted or threatened and no claim or demand shall have been made against any
Seller or Buyer before any  Governmental  Body which has, or, in either  party's
judgment,  might have, a material  adverse  effect on the  financial  condition,
results of operations, prospects, business, properties, assets or liabilities of
the Business or Buyer.

      (g) Consents. All consents necessary to transfer the Included Contracts to
Buyer  shall have been  obtained  in a form  reasonably  satisfactory  to Buyer,
including  consent to the  assignment  of the lease  agreement  for the Woodbury
Facility.

      (h)  Registration  Rights.  Buyer, KMD and all other parties thereto shall
have entered into the Registration Rights Agreement as provided in EXHIBIT D.

      (i) New York State License.  Buyer shall have received notice from the New
York State  Department  of Health that its  Application  for  Laboratory  Permit
(Changes Only), pertaining to KMD's New York State laboratory licenses, PFI 3126
and PFI 4163, has been approved by the State of New York.

      9. ADDITIONAL  CONDITIONS TO THE OBLIGATIONS OF KMD. The obligation of KMD
to  consummate  the   transactions   contemplated   hereby  is  subject  to  the
fulfillment,  on or  prior  to  the  Closing  


                                       25
<PAGE>

Date, of all of the following  conditions,  any or all of which may be waived in
writing by KMD in its sole discretion;

      (a)  Representations  and Warranties.  The  representations and warranties
made by Buyer in Section 5 hereof  shall have been true and  correct on the date
hereof and, except for any  representations and warranties made as of a specific
date,  shall be true and  correct on and as of the  Closing  Date as though such
representations and warranties were made on and as of such date.

      (b)  Performance.  Buyer  shall  have  performed  and  complied  with  all
agreements,   obligations,  covenants  and  conditions  required  herein  to  be
performed or complied with by Buyer on or prior to the Closing Date.

      (c) Purchase Price. KMD shall have received the Closing payment and Shares
in accordance with Section 3(a).

      (d)  Assumption  Agreement.  Buyer shall have  executed and  delivered the
Assumption Agreement to KMD.

      (e) Opinion of Buyer's Counsel. KMD shall have received the signed opinion
of counsel for Buyer, dated the Closing Date, to the effect set forth in EXHIBIT
H.

      (f) Other  Matters.  KMD shall  have  received  such other  documents  and
certificates  as may  reasonably  be  requested  by KMD in  connection  with the
transactions  contemplated hereunder,  including:  (i) an incumbency certificate
and  certified  copy of all  corporate  actions  required for the  execution and
delivery  of this  Agreement  and the  performance  by Buyer of its  obligations
hereunder,  and (ii) an  officer's  certificate,  dated as of the Closing  Date,
certifying  as to the  accuracy  of the  representations  set forth in Article 5
hereto and its compliance with and performance, to the extent such covenants are
capable of being performed as of the Closing Date, of the covenants of Buyer set
forth in Article 7 hereto.

      10.  ADDITIONAL  CONDITIONS TO THE OBLIGATIONS OF BUYER. The obligation of
Buyer to  consummate  the  transactions  contemplated  hereby is  subject to the
fulfillment on or prior to the Closing Date, of all of the following conditions,
any or all of which may be waived in writing by Buyer in its sole discretion:

      (a)  Representations  and Warranties.  The  representations and warranties
made by Seller in Section 4 hereof  shall have been true and correct on the date
hereof and. except for any  representations and warranties made as of a specific
date,  shall be true and  correct on and as of the  Closing  Date as though such
representations and warranties were made on and as of such date.

      (b)  Performance.  Seller  shall  have  performed  and  complied  with all
agreements,   obligations,  covenants  and  conditions  required  herein  to  be
performed or complied with by Seller on or prior to the Closing Date.

      (c)  Condition  of  Assets.  There  shall  have been no  material  damage,
deterioration or casualty loss with respect to the Assets or the Facilities.

      (d) Bill of Sale and Assignment. KMD shall have executed and delivered the
Bill of Sale and Assignment to Buyer.


                                       26
<PAGE>

      (e) Opinion of KMD's Counsel. Buyer shall have received the signed opinion
of Brown  Raysman  Millstein  Felder & Steiner LLP,  counsel for KMD,  dated the
Closing Date, to the effect set forth in EXHIBIT I.

      (f)  Principal's  Certificate.  Buyer  shall  have  received  a  notarized
Principal's  Certificate of KMD, dated as of the Closing Date,  certifying as to
the (A)  satisfaction  of the conditions set forth in clause (a), (b) and (c) of
this Section 10; (B) KMD's compliance with and  performance,  to the extent that
such  covenants  are capable of being  performed as of the Closing  Date, of the
covenants of KMD set forth in Article 6 hereof; (C) incumbency and signatures of
the  Principals  of KMD  executing  this  Agreement  and any  other  Acquisition
Document,  certificate or instrument to be delivered  pursuant  hereto;  and (D)
providing  certified  copies of the unanimous  resolutions of the Principals and
Members of KMD  approving  the  consummation  of the  transactions  contemplated
hereby and that certifying that such resolutions are in full force and effect on
the Closing Date.

       (g) Insurance Tail Coverage.  Sellers shall have delivered to Buyer proof
of insurance evidencing Prior Acts Coverage for the Business, including, without
limitation,  medical professional  liability and comprehensive general liability
coverage,  for a  period  of five  years  following  the  Closing  Date and with
professional  liability coverage and limits of at lease one million ($1,000,000)
per  incident  and three  million  ($3,000,000)  annual  aggregate,  which  tail
coverage  policy of insurance  shall conform with the terms specified in EXHIBIT
J.

       (h) KMD Audit. Sellers shall have cooperated fully in Buyer's efforts and
those of its accountants to audit the books, records and financial statements of
KMD and Buyer's  auditors shall have provided  assurances  satisfactory to Buyer
that a clean,  non-qualified  opinion of KMD's audited financial statements will
be rendered by them.

            (i) Integration.  From and after the date of this Agreement  through
the Closing date, Buyer and its officers,  employees, agents and representatives
shall have had,  after  providing  to KMD oral notice and  explanation  of their
purpose and task,  full access to the Facilities,  its systems,  information and
pertinent  personnel for the purpose of  integrating  KMD into Buyer's  billing,
accounting,  accounts payable, payroll and information systems and other general
and  administrative  functions.  Buyer  covenants  and agrees  that it will not,
during such integration  period,  disable or, in any way, damage, any KMD system
accessed by it, nor, except as temporarily  needed to obtain  information from a
KMD system and except for such  interference or impedance as will not materially
disrupt  the  functioning  of any  KMD  system,  interfere  with or  impede  the
functioning of any KMD system.  Buyer  covenants and agrees that the information
to  be  derived  from  KMD  systems  during  the  integration   process  is  the
confidential  and  proprietary  information  of KMD and shall be governed by the
confidentiality  requirements of Section 12(b),  below.  Buyer covenants that it
shall not use information  obtained from the integration  process to solicit any
KMD  customer  for the sale of  Testing  Services  in the  Territory  should the
Closing fail to occur.

      (j) Other  Matters.  Buyer shall have  received  such other  documents and
certificates  as may  reasonably  be requested by Buyer in  connection  with the
transactions contemplated hereunder.

      11.  CLOSING.  The closing of the  transactions  contemplated  hereby (the
"Closing")  shall take place at the offices of Brown Raysman  Millstein Felder &
Steiner LLP,  located at 120 West 45th Street in New York City, at 10 A.M. local
time, on Thursday,  April 29, 1999, with an effective date of May 1, 1999, or at
such other date mutually satisfactory to the parties hereto, which date shall be
as soon as 


                                       27
<PAGE>

practicable  following the  fulfillment or waiver of the conditions set forth in
Sections 8, 9 and 10 hereof (such date being herein  referred to as the "Closing
Date"').  All  proceedings  to be taken and all  documents  to be  executed  and
delivered  by the  parties at the  Closing  shall be deemed  taken and  executed
simultaneously and no proceeding shall be deemed taken nor any document executed
or delivered until all have been taken, executed and delivered.

      12. PUBLICITY,  CONFIDENTIALITY,  PRESERVATION OF RECORDS.  (a) Each party
hereto  recognizes  and  acknowledges  that the  timing and manner of any public
disclosure of information relating to the transactions contemplated hereby is of
material   importance  to  the  business  and  affairs  of  the  other  parties.
Accordingly,  the  parties  hereto  agree to  consult  with  each  other  and to
cooperate in issuing any press release or other public statement with respect to
the  transactions  contemplated  hereby.  Any such press release or other public
statement may only be issued with the prior consent of the other parties hereto,
which consent shall not be  unreasonably  withheld;  provided,  however  nothing
contained  herein  shall  restrain or  prohibit  any party from making any press
release or other public  disclosure  which,  in the reasonable  judgment of such
party's  counsel  is  required  by  any  applicable  law  or  regulation  of any
Governmental Body or NASDAQ or stock exchange rules and,  provided further,  the
parties shall use reasonable  commercial efforts to provide prior notice of, and
an  opportunity to review and comment upon, and to cooperate with respect to the
timing and content of, any press release or other public disclosure contemplated
by the immediately preceding proviso.

      (b) Sellers and Buyer will hold, and will use their best efforts to cause,
as applicable,  their  respective  Principals,  officers,  managers,  directors,
partners, employees,  accountants,  counsel, consultants, advisors and agents to
hold, in confidence,  unless compelled to disclose by judicial or administrative
process or by other  requirements  of law  (including the rules of the NASDAQ or
any stock  exchange),  all  confidential  documents and information (on whatever
form or media)  concerning  the other party  furnished  in  connection  with the
transactions contemplated by this Agreement,  except that (i) from and after the
Closing, Buyer need not maintain the confidentiality of any information relating
to the Business,  the Assets or the Assumed Obligations,  and (ii) neither party
need  maintain the  confidentially  of any  information  to the extent that such
information can be shown to have been (A) previously known on a non-confidential
basis to such party, (B) in the public domain through no fault of such party, or
(C) later  lawfully  acquired  by such party from  sources  other than the other
party.

      (c) KMD and Buyer  agree  that each of them  shall  preserve  and keep the
records held by them relating to the Business for a period of six (6) years from
the  Closing  Date,  or such  longer  period  of time as is  required  by law or
regulation,  and  shall  make  such  records  available  to the  other as may be
reasonably  required by such party in connection with,  among other things,  any
insurance claims by, legal proceedings, or threatened legal proceedings, against
or  governmental  investigations  or tax  audits of KMD or Buyer or any of their
respective  Affiliates  or in order to enable KMD or Buyer to comply  with their
respective  obligations under this Agreement and each other agreement,  document
or instrument contemplated hereby. See also Section 7(d) above.


      13. CERTAIN TAX COVENANTS.

      (a) Cooperation.  Each of Seller and Buyer shall cooperate with each other
and make available or cause to be made available to each other for consultation,
inspection and copying (at such other party's  expense) in a timely fashion such
personnel, tax data, tax returns and filings, files, books, records,  documents,
financial,   technical  and  operational   data,   computer  records  and  other
information  as 


                                       28
<PAGE>

may be reasonably  required (i) for the  preparation  by Buyer or KMD of any Tax
Returns  prepared  or to be  prepared  and  filed  by  Buyer  or KMD or  (ii) in
connection with any audit or proceeding relating to Taxes for which Buyer or KMD
is responsible.

      (b) Payment of Taxes.  Except for any Taxes arising as a result of actions
taken or  elections  made by Buyer and not agreed to by  Sellers  and except for
Buyer's  obligation  to pay one-half of the New York State bulk sales tax on the
sale of the Assets as provided in Section  3(d) above,  Sellers  shall pay,  and
shall  indemnify  Buyer against all Taxes payable in connection with the sale of
the Assets contemplated hereby.

      14. NONCOMPETITION.

      (a) Sellers  acknowledge that reasonable limits on their ability to engage
in activities  competitive with the Business from and after the Closing Date are
warranted to protect  Buyer's  investment in acquiring the Assets.  Accordingly,
KMD and the  Members  covenant  and agree that from the  Closing  Date until the
third  anniversary  of the Closing Date (such period being referred to herein as
the "Term"), they shall not, without the express prior written consent of Buyer,
which consent may be withheld by Buyer in its sole and absolute discretion,  for
its own account or jointly with any other Person,  directly or indirectly,  own,
manage,  operate, join, control,  finance, invest in, bid for, advise (or advise
others with respect to) or otherwise  participate  in, or be connected  with, or
become  or act as a  partner,  manager,  member,  director,  officer,  employee,
consultant,  representative or agent of, any business, individual,  partnership,
firm,  corporation,  limited  liability  company  or  other  entity  which is in
competition with Buyer, or is otherwise  engaged anywhere within a radius of 150
miles of New York City (the  "Territory")  in any  business,  other than that of
Buyer or its Affiliates,  that offers anatomic pathology,  surgical pathology or
clinical  laboratory testing services  (collectively,  the "Testing  Services");
provided,  however,  that KMD and  Members  may  purchase  or own,  solely as an
inactive  investor,  the  securities  of any entity if (a) such  securities  are
publicly traded on a  nationally-recognized  stock exchange or on NASDAQ and (b)
the aggregate holdings of such securities by KMD and its Members does not exceed
two  percent of the voting  power or two  percent of the  capital  stock of such
entity.

      (b) Each of the Key Persons shall,  as a condition to Closing by Buyer and
in  consideration of the purchase of the Business and Assets of KMD by Buyer and
the  Purchase  Price set forth in Section 3(a) above,  enter into a  restrictive
covenant  with Buyer for a term of three  years  within the  Territory  and with
respect to Testing Services as provided in the Consulting Agreement set forth in
EXHIBIT A and the respective Employment Agreements set forth in EXHIBIT B.

      (c) KMD and each of the Members  hereby  jointly and severally  agree that
during the Term they shall not, directly or indirectly, for their own account or
jointly with or for or on behalf of any other  Person,  as  principal,  agent or
otherwise,  (i) solicit or induce or in any manner  attempt to solicit or induce
any Person  employed by or acting as a consultant to or agent of the Business to
leave such position or (ii)  interfere  with,  disrupt or attempt to disrupt any
relationship,  contractual  or  otherwise,  between the  Business and any of its
customers, clients or suppliers.

      (d) KMD and each of the Members  hereby  jointly and severally  agree that
during the Term they shall not,  use for their own benefit or for the benefit of
any Seller or third Person or,  except as required by law,  disclose the name or
requirements  of any  customer  of KMD or Buyer to any  Person,  or solicit  any
customer of Buyer or any Affiliate of Buyer for the sale of Testing  Services in
the  Territory,  or induce, 


                                       29
<PAGE>

encourage, or attempt to induce or encourage,  any customer for Testing Services
of Buyer or any  Affiliate  of Buyer to reduce such  customer's  purchases  from
Buyer or any Affiliate of Buyer.

      (e) KMD and  each of the  Members  acknowledge  that it has  had,  and may
continue to have access to and the use of confidential materials and information
and trade  secrets  concerning  the Business and Buyer.  No Seller shall use for
itself  or any  other  Person,  or  divulge  or  convey  to any  Person,  except
authorized personnel of Buyer and except as necessary to fulfill the obligations
of this  Agreement,  any secret or confidential  information,  knowledge or data
related to the Business or Buyer. Such information,  knowledge or data includes,
but is not limited to, secret or confidential matters not published or generally
known in the industry, such as information regarding pricing, costs, purchasing,
profits,  markets,  sales  or  customer  lists,  future  developments,   audits,
investigations, enforcement actions, future marketing or expansion plans.

      (f) Each of the Sellers hereby represents and warrants to Buyer that he or
its authorized representative has reviewed this Agreement with his attorneys and
such other  advisors as he or it has deemed  appropriate  and has concluded that
the covenants herein are reasonable and that each of them has adequate financial
and other means and business opportunities to provide for his or its anticipated
needs notwithstanding his covenants herein.

      (g) Sellers  acknowledge  that irreparable harm would be suffered by Buyer
in the event that any of the  provisions  of this Section 14 were not  performed
fully in accordance  with the terms specified  herein and that monetary  damages
are an  inadequate  remedy  for breach  thereof  because  of the  difficulty  of
ascertaining  and  quantifying the amount of damage that will be suffered by the
parties relying hereon in the event that such  undertakings  and provisions were
breached  or  violated.  Accordingly  Sellers  hereby  agree that Buyer shall be
entitled  to an  injunction  or  injunctions  to  restrain,  enjoin and  prevent
breaches or threatened  breaches of the covenants,  undertakings  and provisions
herein and to enforce  specifically  the  provisions  hereof in any court of the
United  States  or any  state  having  jurisdiction  over the  matter,  it being
understood  that any such remedies  shall be in addition to, and not in lieu of,
any other rights and remedies available at law or in equity, including,  without
limitation,  any  remedies  existing  under the  restrictive  covenants  and the
agreements  pertaining thereto required by Section 14(b) above.  Sellers further
acknowledge and agree that the covenants  contained in this Section 14 shall not
be deemed  exclusive  of any common law or other  rights of Buyer in  connection
with the matters covered hereby.

      (h) Nothing in this Section 14 shall be deemed to limit the ability of KMD
to take any action reasonably  necessary for the collection of patient and third
party insurer accounts receivable retained by it under this Agreement.

      15. INDEMNIFICATION.

      (a) Seller Indemnification Sellers hereby jointly and severally (but, with
respect to Sellers  other than KMD,  limited for each Seller to fifty percent of
the  Damages)  agree to  indemnify  Buyer,  its  Affiliates  and its  directors,
officers,  agents,  representatives and employees (collectively "Buyers") and to
hold  Buyers  harmless  from and against  any and all  damage,  loss,  liability
(whether  fixed or  contingent,  known or  unknown,  accrued or  unaccrued)  and
expense   (including   reasonable   expenses  of  investigation  and  reasonable
attorneys,  and other  professionals'  fees and expenses in connection  with any
action,  suit or proceeding)  (collectively,  "Damages") incurred or suffered by
Buyers, or any of them, arising out of or in respect of the following:


                                       30
<PAGE>


            (i) any  material  misrepresentation  or breach of  representation
      or warranty of Sellers, or any of them, contained herein;

            (ii) any breach of covenant or agreement  made or to be performed by
      Sellers or any of them pursuant to this Agreement;

            (iii)  any and all Retained Liabilities;

             (iv) except as provided in Section  7(c) above,  any and all claims
      relating to the  employment  or  termination  of  employment by KMD of any
      Person,  or for  compensation  and  other  employee  benefits  (including,
      without  limitation,  severance  benefits,  disability or  post-retirement
      benefits,  health,  workers'  compensation and death benefits) and any and
      all claims with respect to any employee benefit or welfare plan maintained
      or  contributed  to by KMD or its  Affiliates  or any  other  claim by any
      employee  of KMD,  whether or not hired by Buyer and  except as  expressly
      provided  for herein,  for any accrued  compensation  or benefit  owing or
      maintained  by KMD arising out of services  rendered  prior to the Closing
      Date;

            (v)  any  violation  or  alleged   violation  of  law  by  KMD,  its
      Principals,  managers,  employees  or agents or of any of the  Members  or
      their respective officers,  directors,  partners,  employees or agents and
      any  action  or claim  for  overpayment,  restitution,  civil or  criminal
      penalties  or other  Damages  arising out of the  conduct of the  Business
      prior to the Closing;

            (vi)  KMD's  failure to pay any "bulk  sales"  taxes for which it is
      liable hereunder applicable to the sale of the Assets; and

             (vii)  Sellers'  failure to discharge  KMD's  accounts  payable and
 other current liabilities in accordance with Section 2(e) above.

            Other  than  with  respect  to those  Sellers'  representations  and
warranties set forth in Sections 4(b) and 4(f) and Subsection 4(t)(i), above, no
indemnification  shall be payable to Buyer with respect to claims asserted under
Subsection 15(a)(i),  above, if not asserted by Buyer within two (2) years after
the Closing Date. No  indemnification  shall be payable to Buyer with respect to
claims   asserted   under   Subsection   15(a)(i)   with   respect   to  Sellers
representations  and warranties set forth in Section 4(b) and Subsection 4(t)(i)
if not  asserted  by Buyer  within five (5) years and thirty (30) days after the
Closing  Date.  No  indemnification  shall be payable  to Buyer with  respect to
claims  asserted under  Subsection  15(a)(ii),  above,  if not asserted by Buyer
within four (4) years after the Closing Date. For purposes of this provision and
Section 15(b),  below, a claim is asserted on the date on which a general notice
of such  claim  has been  given to the  Indemnifying  Party in  accordance  with
Article 17, below.

      (b) Buyer  Indemnification.  Buyer hereby agrees to indemnify  Sellers and
their directors,  officers, agents,  representatives and employees (collectively
"Sellers")  and to hold  Sellers  harmless  from and against any and all Damages
incurred or suffered by Sellers  arising out of or in respect of the  following:
(i) any breach of  representation  or warranty of Buyer under this Agreement,  a
claim for which, except for those  representations and warranties of Buyer under
Section  5(b) above,  is asserted  within two (2) years after the Closing  Date;
(ii) any breach of representation or warranty of Buyer under Section  5(b)above,
a claim for which is  asserted  within five (5) years and thirty (30) days after
the  Closing  Date;  (iii) any breach of a covenant or  agreement  made or to be
performed  by Buyer  pursuant to this  Agreement,  a claim for which is asserted
within four (4) years after the Closing Date  (except that an alleged  breach of
Buyer's  covenant  to  provide  access  to  slides,  specimens  and  records  in
accordance with Section 7(d) above,  shall have a claim period of five (5) years
after the  Closing  Date or such  longer  time period as is required by law with
respect to the  retention  of such  slides,  specimens  and  records);  (iv) the


                                       31
<PAGE>

Assumed  Obligations;  (v) the operation of the Assets and the Business from and
after the  Closing  Date,  except  with  respect to Damages  incurred  after the
Closing  Date that  were  caused  by or arose  from a breach of any of  Sellers'
representations, warranties, covenants or agreements contained in this Agreement
and except for any  alleged  decline in the value of the Shares  resulting  from
Buyer's operation of the Assets and Business after the Closing Date; (vi) except
as provided in Section 7(c) above, any and all claims relating to the employment
or termination of employment by Buyer of any Person,  other than Key Persons, or
for  compensation  and other of Buyer's  employee  benefits  (including  without
limitation,  its  severance,  disability or  post-retirement,  health,  workers'
compensation  and death  benefits)  and any and all claims  with  respect to any
employee  benefit or welfare plan  maintained or  contributed to by Buyer or any
other  claim by any  employee,  other than Key  Employees,  of Buyer,  except as
required  to be paid by  Sellers  hereunder,  for any  accrued  compensation  or
benefit owing or  maintained by Buyer arising out of services  rendered to Buyer
after the Closing Date; and (vii) Buyer's failure to pay any New York State bulk
sales tax for which it is liable under Section 3(d), above.

      (c) Procedures  for Claims.  A party seeking  indemnification  pursuant to
this Section 15 (an  "Indemnified  Party") from or against the  assertion of any
claim, or the  commencement of any action,  suit or proceeding by a third Person
in  respect of which  indemnity  may be sought  under this  Section is (a "Third
Person   Assertion")   shall  give   prompt   notice  to  the  party  from  whom
indemnification  is sought  (the  "Indemnifying  Party")  and shall  provide the
Indemnifying  Party such  information  with respect thereto as the  Indemnifying
Party may reasonably request, but no failure to give such notice or provide such
information  shall relieve the  Indemnifying  Party of any  liability  hereunder
(except to the extent that the Indemnifying  Party has suffered actual prejudice
by such failure).  No Indemnified  Party shall settle any Third Person Assertion
without the prior written consent of the Indemnifying Party, which consent shall
not be unreasonably  withheld or delayed.  The Indemnifying Party shall have the
right,  exercisable by written notice to the  Indemnified  Party within ten (10)
Business Days of receipt of notice from the Indemnified Party pursuant hereto of
a Third Person Assertion,  to assume the defense of such Third Person Assertion.
If the  Indemnifying  Party assumes such  defense,  the  Indemnifying  Party may
select counsel,  which counsel shall be reasonably acceptable to the Indemnified
Party. If the Indemnifying Party does not assume the defense of any Third Person
Assertion in accordance with the preceding  sentences or, having so assumed such
defense, unreasonably fails to defend against such Third Person Assertion at any
time after the  Indemnifying  Party shall have assumed the defense of such Third
Person  Assertion,  then  upon  five  (5)  days'  prior  written  notice  to the
Indemnifying  Party, the Indemnified  Party may assume the defense of such Third
Person  Assertion  and shall have the right to consent to the entry of  judgment
with  respect to, or otherwise  settle,  such Third  Person  Assertion  with the
consent of the  Indemnifying  Party,  which  consent  shall not be  unreasonably
withheld.  In such event,  the  Indemnified  Party shall be entitled  under this
Section 15, as part of its Damages,  to indemnification for the reasonable costs
of such defense The Indemnifying  Party, if it shall have assumed the defense of
any Third  Person  Assertion,  shall  have the right to  consent to the entry of
judgment with respect to, or otherwise settle,  such Third Person Assertion with
the consent of the  Indemnified  Party,  which consent shall not be unreasonably
withheld;  provided, however, that the Indemnified Part may withhold its consent
if (1) any such  judgment  imposes a continuing  non-monetary  obligation on the
Indemnified   Party  or  any  of  its  Affiliates,   (2)  does  not  include  an
unconditional  release  of the  Indemnified  Party and its  Affiliates  from all
liability in respect of claims that are the subject  matter of such Third Person
Assertion,  or (3) may result in a loss,  suspension or other restriction of any
license or right to  participate  as a provider  under any  Federal  Health Care
Program,  State Health Care Program or CHAMPUS.  The Indemnifying  Party and the
Indemnified  Party shall  cooperate,  and cause their  respective  Affiliates to
cooperate, in the defense or prosecution of any Third Person Assertion and shall
furnish or cause to be furnished such records,  information  and testimony,  and
attend such conferences,  discovery proceedings,  hearings, trials or appeals as
may  be  


                                       32
<PAGE>

requested in connection  therewith.  The  Indemnifying  Party or the Indemnified
Party,  as the case may be,  shall  have the  right to  participate,  at its own
expense,  in the defense or settlement of any Third Person  Assertion  which the
other is defending.

      (d) In the event an  Indemnified  Party  should  have a claim  against any
Indemnifying  Party under this  Section 15 that does not involve a Third  Person
Assertion,  the  Indemnified  Party  shall  deliver  notice of such  claim  with
reasonable  promptness to the Indemnifying Party. If the Indemnifying Party does
not notify the Indemnified Party within sixty (60) days following its receipt of
such  notice  that  the  Indemnifying   Party  disputes  its  liability  to  the
Indemnified  Party under  Section 15, such claim  specified  by the  Indemnified
Party  in  such  notice  shall  be  conclusively   deemed  a  liability  of  the
Indemnifying  Party and the  Indemnifying  Party  shall  pay the  amount of such
liability to the  Indemnified  Party within five days after  expiration  of such
60-day  period.  If the  Indemnifying  Party timely  disputes its liability with
respect to such claim,  the Indemnifying  Party and the Indemnified  Party shall
proceed in good faith to  negotiate a  resolution  of such  dispute  and, if not
resolved within thirty (30) days,  either party may institute legal  proceedings
relating thereto.

       (e)  Threshold.   Except  as  otherwise   expressly  provided  below,  no
indemnification  pursuant to Article 15 shall be  required  of the  Indemnifying
Party  except to the  extent  that,  at the time of the  applicable  claim,  the
aggregate amount due the Indemnified  Party for all claims brought under Article
15 through the date thereof (the "Aggregate Amount") shall exceed fifty thousand
($50,000) dollars (the "Threshold").  In the event that the Aggregate Amount due
an  Indemnified  Party  under  this  Article  15  exceeds  the  Threshold,   the
Indemnifying  Party  shall,  at that  time,  pay to the  Indemnified  Party  the
Aggregate  Amount.  Notwithstanding  the  foregoing,  no  claim  asserted  under
Subsections  15(a)(iv),   15(a)(vi)  or  15(a)(vii)  shall  be  subject  to  the
Threshold.

      (f)    Ceiling.  The Indemnifying Party shall be liable to the Indemnified
Party under this Article 15 only for the first ten million five hundred thousand
($10,500,000)  dollars of the  Aggregate  Amount  during the first twelve months
following  the Closing  Date and for the first  thirteen  million  ($13,000,000)
dollars of the Aggregate Amount thereafter.

      16.    TERMINATION.  (a) This  Agreement  may be  terminated at any time
prior to the Closing as follows:
            (i) by mutual written consent of KMD and Buyer;

            (ii) by  Sellers if there  shall have been a breach by Buyer,  or by
      Buyer if  there  shall  have  been a breach  by  Sellers,  of any of their
      respective representations and warranties set forth in this Agreement, (A)
      if such breach is  reasonably  capable of being  cured  within 10 Business
      Days  following  receipt by the breaching  party of written notice of such
      breach,  then upon  delivery of written  notice of  termination  following
      termination  of such 10  Business  Day period if such  breach has not been
      cured by such time or, if such breach is not  reasonably  capable of being
      cured within 10 Business Days following  receipt of written notice of such
      breach,  then upon one Business Day's prior written notice of termination,
      and (B) in each case of a breach  that  would  entitle  the  non-breaching
      party not to consummate the transactions contemplated hereby under Section
      9(a) (in the case a breach  of  representation  or  warranty  by Buyer) or
      Section  10(a) (in the case of a breach of  representation  or warranty by
      Sellers);

            (iii) by  Sellers  if there  shall  have been a  material  breach by
      Buyer,  or by Buyer if there shall have been a material breach by Sellers,
      of any of their covenants or agreements set forth in 


                                       33
<PAGE>

      this  Agreement,  which  breach  shall not have been cured within ten (10)
      Business Days following  receipt by the breaching  party of written notice
      of such breach from Sellers or Buyer, as the case may be; and

      Notwithstanding  Section  16(a)(ii)-(iii),   a  party  who  is,  or  whose
Affiliate is, in material  breach of any of its  obligations or  representations
and  warranties  hereunder  shall not have the right to terminate this Agreement
pursuant to Section 16(a)(ii) or (iii).

      The  termination of this Agreement shall be effectuated by the delivery by
the party  terminating  this Agreement to the other party of a written notice of
such termination. If this Agreement so terminates, it shall become null and void
and have no further force or effect, except as provided in Section 16(b).

      Notwithstanding anything to the contrary in this Agreement, neither Buyer,
nor any of the Sellers,  may terminate  this  Agreement on the basis that either
KMD or Buyer has suffered a Material  Adverse Effect during the time period from
the date of this Agreement and the Closing Date.

       (b)  Survival  After  Termination.  If this  Agreement is  terminated  in
accordance with Section 16(a) hereof and the  transactions  contemplated  hereby
are not  consummated,  this Agreement  shall become void and of no further force
and effect,  except for the provisions of Sections  12(a),  12(b),  14(e) (as to
secret or confidential information of Buyer and KMD) and 17, which shall survive
termination of this  Agreement.  None of the parties shall have any liability in
the event of a  termination  of this  Agreement,  except to the extent that such
termination  results  from the  breach by such  party of any of its  obligations
under,  or a breach of its  representations  or  warranties  contained  in, this
Agreement.  In the event of a termination as a result of the breach by any party
of its  obligations  under,  or a breach of its  representations  or  warranties
contained in, this Agreement,  the other party shall be entitled to all remedies
at law or in equity which may be available as a result of such breach.

      17.  NOTICES.  Any and all  notices or other  communication  provided  for
herein  shall  be  made  by  hand-delivery,   first-class  mail  (registered  or
certified, return receipt requested),  facsimile or overnight air courier (i) in
the case of Sellers to: Tribute  International  Corporation,  173 Crossways Park
Drive West, Woodbury, New York, 11797, facsimile (516) 921-3637,  Attention:  A.
Bruce Shapiro, with a copy (which shall not constitute notice) to: Brown Raysman
Millstein Felder & Steiner LLP, 120 West 45th Street,  New York, New York 10036,
facsimile (212) 840-2429, Attention: Sarah Hewitt, Esq.; and (ii) in the case of
Buyer, to DIANON Systems,  Inc., 200 Watson  Boulevard,  Stratford,  Connecticut
06615, facsimile (203) 380-4138, Attention: Chief Executive Officer, with a copy
(which shall not  constitute  notice) to:  Cadwalader,  Wickersham  & Taft,  100
Maiden Lane,  New York, New York 10038,  facsimile  (212)  504-5557,  Attention:
Dennis J. Block, Esq. Except as otherwise provided in this Agreement,  each such
notice  shall be  deemed  given at the time  delivered  by hand,  if  personally
delivered;  five (5) Business  Days after being  deposited in the mail,  postage
prepaid, if mailed; when answered-back with receipt acknowledged,  if telefaxed;
and the next  Business  Day after  timely  delivery to the  courier,  if sent by
reputable overnight air courier guaranteeing next day delivery.

      18. BULK SALES LAWS. The parties  hereby waive  compliance by KMD with the
requirements  of  Article  6 of the  Uniform  Commercial  Code as in  effect  in
relevant  jurisdictions,  and KMD and the Members  hereby  covenant and agree to
indemnify Buyer and hold Buyer harmless from any costs or liabilities  resulting
from such non-compliance.

      19. GENERAL.


                                       34
<PAGE>


      (a) Entire Agreement. This Agreement, including the Exhibits and Schedules
hereto,  contains the entire  understanding  and agreement of the parties hereto
with respect to the subject matter hereof.

      (b) Survival. The covenants and agreements of the parties contained herein
shall survive the  execution and delivery of this  Agreement and the purchase of
the Assets. All  representations  and warranties  contained herein shall survive
the execution and delivery of this Agreement, any examination by or on behalf of
the  parties  hereto,  the  Closing  and  the  completion  of  the  transactions
contemplated  herein  for a period of two (2) years  commencing  on the  Closing
Date, provided,  however, that (i) the representations and warranties of Sellers
contained in Sections  4(b) and 4(t)(i)  shall survive the Closing and remain in
full force and effect for a period of five (5) years  commencing  on the Closing
Date, and (ii) the expiration of any  representation or warranty shall in no way
limit or compromise the  obligation of Sellers to indemnify  Buyers with respect
to the Retained Liabilities.  Notwithstanding anything to the contrary contained
herein,  a  representation  or  warranty  that  is the  basis  for a  claim  for
indemnification  timely made hereunder shall continue to survive with respect to
such claim until the final resolution of such claim.

      (c)  Further  Assurances.  The parties  hereto each agree to execute  such
other  instruments,  documents or agreements  as may be reasonably  necessary or
desirable for the  implementation  of this Agreement and the consummation of the
transactions  contemplated  thereby.  In addition,  the parties  hereto agree to
provide reasonable access to such party's personnel,  documents and materials at
the visiting  party's  expense and with as little  business  interference to the
party  providing such access as is feasible under the  circumstances,  as may be
reasonably  necessary or desirable for the  implementation of this Agreement and
the consummation of the transactions contemplated hereby.

      (d) Amendment:  Waiver.  This Agreement may be amended or waived only by a
written  instrument  signed by the party  against  whom  enforcement  thereof is
sought.

      (e) Binding Effect:  Assignment.  This Agreement shall be binding upon and
inure to the  benefit of the  parties  hereto and their  respective  successors,
legal  representatives and permitted assigns;  provided,  however, that no party
may delegate or otherwise transfer any of its rights or obligations hereunder by
operation of law or otherwise,  without the prior  written  consent of the other
party, and any purported assignment without such consent shall be null and void,
except  that  Buyer  may  assign  any  of  its  rights  or  delegate  any of its
obligations  hereunder to any wholly owned  subsidiary  of Buyer  without  KMD's
consent upon ten (10) days prior written notice to Sellers, and, in the event of
any  such  assignment,  Buyer  shall  not  be  relieved  of  liability  for  the
performance of any obligations so delegated.

      (f) Section Headings. The section headings contained in this Agreement are
for  reference  purposes  only and shall not  affect in any way the  meaning  or
interpretation of this Agreement.

      (g) Governing  Law.  This  Agreement  shall be governed by and  construed,
interpreted  and enforced in  accordance  with the laws of the State of New York
without giving effect to the policies or principles thereof respecting  conflict
or choice of laws.

      (h) Jurisdiction.  The parties hereto consent to personal  jurisdiction in
the courts of the State of New York and the United States District Court for the
Southern or Eastern  Districts therein in connection with any action arising out
of the Acquisition Documents. Each party irrevocably waives its 


                                       35
<PAGE>

right to a trial by jury and consents  that service of process may be by mail in
accordance with the notice provisions of Section 17.

      (i)  Severability.  The provisions of this Agreement are severable and the
invalidity  of any  provision  shall  not  affect  the  validity  of  any  other
provision. It is the intention of the parties that this Agreement be enforced to
the fullest extent permitted and, therefore,  in the event that any provision of
this Agreement or the  application  thereof is held to be  unenforceable  in any
jurisdiction  because of the duration or scope thereof, the parties hereto agree
that the court or panel of arbitrators making such determination  shall have the
power to reduce the duration and scope of such provision to the extent necessary
to make it  enforceable,  and that the  Agreement  in its reduced  form shall be
valid  and  enforceable  to the  full  extent  permitted  by  law,  but no  such
invalidity  or reduction  shall affect the  enforceability  of the express terms
hereof in any other jurisdiction.

      (j)  Expenses.  Each party  hereto  shall pay its own fees and expenses in
connection with this Agreement.

      (k)  Counterparts.   This  Agreement  may  be  executed  in  one  or  more
counterparts,  each of which shall be deemed an original, but all of which taken
together shall constitute but one and the same agreement.











            [The remainder of this page left intentionally blank]






                                       36
<PAGE>







      (l) No Third Party  Beneficiaries.  Except as expressly  set forth in this
Agreement,  nothing herein,  express or implied,  is intended to or shall confer
upon any Person  (including  any employee of KMD or Sellers or Buyer) other than
the parties hereto and the Persons  described in Sections 15(a) and 15(b) above,
any legal or equitable right benefit or remedy of any nature whatsoever under or
by reason of this Agreement.


      IN WITNESS WHEREOF,  the parties hereto have executed this Agreement as of
the day and year first written above.


                              DIANON SYSTEMS, INC.


                                    By:   /s/ Kevin C. Johnson
                                          --------------------
                                          Name: Kevin C. Johnson
                                          Title: President & CEO

                                    KYTO MERIDIEN DIAGNOSTICS, L.L.C.


                                    By:   /s/ Ralph M. Richart
                                          --------------------
                                          Name :  Ralph M. Richart
                                          Title:  President of General 
                                                   Partner of Member

                             KYTO DIAGNOSTICS, L.P.


                                    By:   /s/ Ralph M. Richart
                                          --------------------
                                          Name :  Ralph M. Richart
                                          Title:  President of General Partner

                                    MERIDIEN DIAGNOSTICS LABS, INC.


                                    By:   /s/ A. Bruce Shapiro
                                          --------------------
                                          Name:  A. Bruce Shapiro
                                          Title:  President


                              /s/ A. Bruce Shapiro 
                              --------------------
                                A. Bruce Shapiro



                              /s/ Ralph M. Richart
                              --------------------
                             Ralph M. Richart, M.D.




                                       37




                                                                  EXHIBIT 10.2


                        REGISTRATION RIGHTS AGREEMENT


            THIS REGISTRATION  RIGHTS  AGREEMENT,  dated as of May 1, 1999 (this
"Agreement"),  is by and between DIANON  SYSTEMS,  INC., a Delaware  corporation
(the  "Company"),  and KYTO  MERIDIEN  DIAGNOSTICS,  L.L.C.,  a New York limited
liability company ("KMD").


            WHEREAS,  pursuant to that certain Asset Purchase Agreement dated as
of April 7, 1999 by and among the Company, KMD, Kyto Diagnostics, L.P., Meridien
Diagnostics  Labs,  Inc.,  A. Bruce  Shapiro and Ralph M.  Richart,  on the date
hereof,  KMD became the owner of 300,000  shares of the Company's  common stock,
par value $.01 per share (the "Shares");


            WHEREAS,  the Shares have not been  registered  under the Securities
Act (as hereinafter  defined) or any state securities laws, and the certificates
representing the Shares bear a legend restricting their transfer; and


            WHEREAS,  in connection with the foregoing,  the Company has agreed,
subject to the terms, conditions and limitations set forth in this Agreement, to
provide KMD and its successors, assigns and transferees as permitted herein with
certain registration rights in respect of the Shares.


            NOW,  THEREFORE,  in  consideration  of  the  mutual  covenants  and
promises contained herein, the parties hereto agree as follows:


DEFINITIONS

            1.1  Definitions.   Capitalized  words  and  phrases  used  and  not
otherwise defined in this Agreement shall have the following meanings:

            "Commission"  means the  Securities  and Exchange  Commission or any
other federal agency at the time administering the Securities Act.

            "Common Stock" means the common stock,  par value $.01 per share, of
the Company (including, without limitation, the Shares) and all shares hereafter
authorized  of any class of common stock of the  Company,  and, in the case of a
reclassification,  recapitalization or other similar change in such Common Stock
or in the case of a consolidation  or merger of the Company with or into another
Person,  such  consideration  to which a holder of a share of Common Stock would
have been entitled upon the occurrence of such event.

            "Company"  includes,  in addition to the Company,  any  successor or
assignee corporation or corporations into which or with which the Company may be
merged or consolidated, any corporation for whose shares the Common Stock may be
exchanged  and any assignee of or successor to all or  substantially  all of the
assets of the Company.


<PAGE>

            "Exchange  Act"  means the  Securities  Exchange  Act of 1934,  as
amended.

            "Holder" means KMD, and each Person who is a Permitted  Transferee
of KMD.

            "NASDAQ"  means The  Nasdaq  Stock  Market's  Automated  Quotation
System--National Market.

            "Permitted Transferee" means any corporation,  partnership,  limited
liability  company or other Person  controlled  by,  controlling or under common
control with KMD to which KMD has  Transferred the Shares.  Notwithstanding  any
Person's  status  as  a  Permitted  Transferee,   any  Transfer  of  Registrable
Securities shall be subject to the provisions of Section 8.1.

            "Person" means any individual,  corporation,  partnership,  trust or
other entity of any nature whatsoever.

            "Register," "registered," and "registration," when used with respect
to the capital stock of the Company,  means a registration effected by preparing
and filing a registration  statement or similar  document in compliance with the
Securities Act with the Commission which has been declared or ordered  effective
by the Commission in accordance with the Securities Act.

            "Registrable  Securities"  means the Shares  (and shall  include all
shares of Common Stock received by the Holder in respect  thereof  pursuant to a
stock split, stock dividend or other recapitalization of the Company or pursuant
to any merger,  consolidation  or  reorganization  involving the  Company).  The
Shares  shall  cease  to be  Registrable  Securities  when  (i)  a  registration
statement  with  respect  to the sale of all of the  Shares  shall  have  become
effective  under the  Securities  Act and the Shares shall have been disposed of
pursuant to such registration statement, (ii) the Shares shall have been sold or
otherwise  distributed  pursuant to Rule 144 (or any successor  provision) under
the Securities Act in accordance with the volume and other limitations  thereof,
or (iii) the Shares shall have ceased to be outstanding.

            "Securities  Act" means the Securities Act of 1933, as amended,  and
the rules and regulations of the Commission promulgated thereunder.

            "Transfer" means any transfer, sale, gift, assignment, distribution,
conveyance, pledge, hypothecation, encumbrance or other voluntary or involuntary
transfer of title or beneficial interest,  whether or not for value,  including,
without  limitation,  any  disposition  by  operation  of law or any  grant of a
derivative or economic interest therein.


PIGGYBACK REGISTRATION

      1.2 Notice of Registration.  (a) If at any time after the date hereof, the
Company  proposes  to  register  any of its  Common  Stock,  either  for its own
account,  or for the  account  of any  Person  other  than the  Holder,  but not
including (i) a  registration  relating to employee  stock  option,  purchase or
other  employer  plans  or (ii) a  registration  on Form  S-4 or Form S-8 or any
successor form thereto (a "Piggyback Registration"), the Company will:


                                       2
<PAGE>

                  (X) promptly give written  notice  thereof to the Holder prior
to the proposed date of filing; and

                  (Y)  use  its  best  efforts  to  include  in  such  Piggyback
Registration  and  in  any  underwriting  involved  therein  up to  all  of  the
Registrable  Securities  which the Holder  requests in writing to be so included
within 30 days after receipt of such written  notice from the Company,  provided
that the  Company  may  request  the  Holder to enter into such  agreements  and
documents as are customary in the securities business for an arrangement between
an underwriter and a company of the Company's size and investment stature and as
are reasonably requested to evidence the commitment of the Holder to participate
in  the   registration,   including   customary   custody  and   indemnification
arrangements. 

           (b) The Holder shall have the right to exercise its right pursuant to
Section 2.1(a) only once; provided, however, that the Holder will be entitled to
exercise its rights  pursuant to Section 2.1(a) more than once if (x) the number
of  Registrable  Securities  that the  Holder  elected  to  include in any prior
registration was reduced by the managing  underwriter(s) or the Company,  as the
case may be, pursuant to Section 2.4, or (y) the Piggyback Registration in which
Registrable  Securities  were  to  be  included  was  withdrawn,   cancelled  or
permanently suspended pursuant to Section 2.5 or Section 4.2.

            Notwithstanding  the foregoing,  the Holder shall not be entitled to
exercise its  Piggyback  Registration  right if the Company shall have filed and
maintained  effective  a  shelf  registration   statement  for  the  Registrable
Securities for at least 180 days. 

      1.3  Expenses.  The  Company  shall pay,  and shall  reimburse  Holder for
paying,  any  expenses  incurred in  connection  with a  Piggyback  Registration
requested  pursuant  to  Section  2.1(a),  including,  without  limitation,  all
registration,  qualification,  printing  and  accounting  fees  and all fees and
disbursements  of counsel for the  Company,  provided  that Holder shall pay all
underwriting  discounts and commissions  with respect to Registrable  Securities
included in such  registration  statement  as well as fees or  disbursements  of
counsel, accountants or other professionals for Holder.

      1.4 Underwriting. If the registration of which the Company gives notice is
for a registered public offering involving an underwriting, the Company shall so
advise the Holder as a part of the  written  notice  given  pursuant  to Section
2.1(a),  and the right of the Holder to include  Registrable  Securities in such
registration  shall be  conditioned  upon  the  Holder's  participation  in such
underwriting  and the  entry  of the  participating  Holder  (together  with the
Company  and  other  holders   distributing   their   securities   through  such
underwriting)  into  an  underwriting  agreement  in  customary  form  with  the
underwriter or underwriters selected for such underwriting by the Company.

      1.5  Priority.  (a) If the  managing  underwriter(s)  (in  the  case of an
underwritten  registration)  or the  Company  (in the  case of  non-underwritten
registration)   should  reasonably  object  to  the  exercise  of  the  Holder's
registration  rights as set forth herein or if the managing  underwriter(s)  (in
the  case of an  underwritten  registration)  or the  Company  (in the case of a
non-underwritten registration) should reasonably determine that the inclusion of
the Registrable  Securities would adversely affect the offering  contemplated in
such  Registration  Statement,   and  based  on  such  determination  recommends
inclusion in such  registration of fewer or none of the 


                                       3
<PAGE>

Registrable  Securities,  then securities  shall be included in such offering in
the following order of priority:

          if such registration as initially proposed by the Company was solely a
primary  registration of its securities,  (x) first, the securities  proposed by
the Company to be sold for its own account,  (y) second,  any  securities of the
Company  proposed  to be  included  in such  registration,  allocated  among the
holders  thereof in  accordance  with the  priorities  then  existing  among the
Company and such holders, and (z) third, any Registrable Securities requested to
be included in such registration by Holder pursuant to Section 2.1., pro rata on
the basis of the number of  Registrable  Securities  requested to be included by
Holder plus the number of any other  securities  of the  Company  proposed to be
included in such registration pursuant to any other Person's exercise of similar
"piggyback" registration rights granted by the Company;

         if such registration as initially  proposed by the Company was in whole
or in part requested by holders of securities of the Company, other than holders
of  Registrable  Securities  in their  capacities  as such,  pursuant  to demand
registration  rights,  (x) first, such securities held by the holders initiating
such registration and, if applicable,  any securities proposed by the Company to
be sold for its own account,  allocated in accordance  with the priorities  then
existing among the Company and such holders,  (y) second,  any securities of the
Company  proposed  to be  included  in such  registration,  allocated  among the
holders  thereof in  accordance  with the  priorities  then  existing  among the
Company and such holders, and (z) third, any Registrable Securities requested to
be included in such registration by Holder pursuant to Section 2.1., pro rata on
the basis of the number of  Registrable  Securities  requested to be included by
Holder plus the number of any other  securities  of the  Company  proposed to be
included in such registration pursuant to any other Person's exercise of similar
"piggyback" registration rights granted by the Company.

            Any securities  excluded  pursuant to the provisions of this Section
2.4  shall be  withdrawn  from  and  shall  not be  included  in such  Piggyback
Registration. 

           (a) Notwithstanding the provisions of Section 2.4(a), the Company, in
its sole and absolute  discretion  upon approval of its Board of Directors,  may
enter  into  agreements  granting  Persons  other  than the  Holder the right to
include  any  securities  issued or  issuable  to such  Persons  in a  Piggyback
Registration  on a pro rata basis with the  inclusion  of  Holder's  Registrable
Securities  (to the extent such Persons do not  expressly  consent in writing to
the  inclusion  of  such  securities  on  a  basis  subordinate  to  Registrable
Securities).

      1.6 Company's Obligations. The rights of Holder, under this Article II are
solely  piggyback in nature,  and nothing in this  Agreement  shall  prevent the
Company  from  reversing a decision  to file a  Registration  Statement  or from
withdrawing  or delaying any such  Registration  Statement  before it has become
effective.


HOLDBACK AGREEMENTS

      1.7 Restrictions on Public Sale by Holder.  Holder agrees, if requested in
writing by:

      the managing  underwriter or underwriters  in an underwritten  offering of
Registrable  Securities covered by a registration  statement filed pursuant to a
Piggyback Registration; or


                                       4
<PAGE>

      the  managing  underwriter  or  underwriters  in an  underwritten  primary
offering of securities of the Company made pursuant to the Securities Act;

not to  effect  any  public  sale or  distribution  of any  Common  Stock or any
securities  convertible  into or  exchangeable  or exercisable for Common Stock,
including a sale  pursuant to Rule 144 (or any  successor  provision)  under the
Securities  Act  (except  to  the  extent  included  in  any  such  offering  or
distribution  pursuant to Section 2.1), during the period starting with the date
10 days prior to and ending on the earlier of the date 90 days after the closing
date of any  such  offering,  sale or  distribution  or 180 days  following  the
effective date of the registration statement filed in connection therewith.  

      1.8 No Participation in Other Securities Offerings.  The rights granted by
the  Company  hereunder  shall be the  exclusive  rights  granted to Holder with
respect to Registrable  Securities.  Except as otherwise provided herein, Holder
shall have no rights to participate in any offering of securities by the Company
to third parties,  including without  limitation,  any offering of Common Stock,
whether such offering is effected pursuant to registration  under the Securities
Act or pursuant to an exemption from registration thereunder.

      1.9 Release from  Restrictions.  The Company may, in its sole and absolute
discretion,  elect to waive the applicability in any particular  instance of the
provisions of Section 3.1 and Section 3.2.


REGISTRATION PROCEDURES

      1.10  Registration  Procedures.  In the  case of each  registration  to be
effected  by the Company in which any Holder is  participating  pursuant to this
Agreement,  the  Company  will keep the  Holder  advised  in  writing  as to the
initiation of each registration and as to the completion  thereof. In connection
with each such offering,  the Company shall as expeditiously as possible, at its
sole expense:  

           (a)  prepare  (and  afford  counsel  for the Holder up to 10 business
days'  opportunity to review and comment thereon) and file with the Commission a
registration  statement with respect to such Holder's Registrable Securities and
use its best efforts to cause such  registration  statement to become and remain
effective, for a period of at least 180 days or until the distribution described
in the registration  statement  relating  thereto has been completed,  whichever
shall first occur;

           (b) furnish to the Holder and to the  underwriters  of the securities
being  registered  such  number  of  copies  of  the   registration   statement,
preliminary prospectus, final prospectus and other documents incident thereto as
such underwriters and the Holder from time to time may reasonably request;

           (c)  prepare  (and  afford  counsel  for the Holder up to 10 business
days'  opportunity  to review and comment  thereon) and file with the Commission
such  amendments  and  supplements  to  such  registration   statement  and  the
prospectus  used  in  connection  with  such  registration  statement  as may be
necessary to comply with the  provisions of the  Securities  Act with respect to
the disposition of all securities covered by such registration  statement and to
keep the  registration  statement  effective for the period  specified in 4.1(a)
above;


                                       5
<PAGE>

           (d) use its best  efforts  to  register  or qualify  the  Registrable
Securities covered by such registration statement under such other securities or
Blue Sky laws of such  jurisdictions  as shall be  reasonably  requested  by the
Holder  for  the  distribution  of the  Registrable  Securities  covered  by the
registration statement to be sold by the Holder; provided that the Company shall
not be required in connection  therewith or as a condition thereto to qualify to
do  business  or to file a general  consent  to  service  of process in any such
states or jurisdictions;

           (e)  enter  into an  underwriting  agreement  in  customary  form and
substance  reasonably  satisfactory to the Company,  the Holder and the managing
underwriter or underwriters of the public  offering of such  securities,  if the
offering is to be underwritten, in whole or in part;

           (f) notify the Holder, at any time when a prospectus relating thereto
covered by such  registration  statement is required to be  delivered  under the
Securities  Act,  of the  happening  of any  event  as a  result  of  which  the
prospectus included in such registration  statement, as then in effect, includes
an  untrue  statement  of a  material  fact or omits to  state a  material  fact
required to be stated  therein or necessary to make the  statements  therein not
misleading in the light of the circumstances then existing;

           (g)  furnish,  at the  request  of the  Holder  on the date  that any
Registrable  Securities  are to be  delivered  to the  underwriters  for sale in
connection with a registration  pursuant to this  Agreement,  if such securities
are being sold through  underwriters,  or, if such securities are not being sold
through underwriters,  on the date that the registration  statement with respect
to such securities  becomes effective,  (i) an opinion,  dated such date, of the
counsel representing the Company for the purposes of such registration,  in form
and substance as is customarily given to underwriters in an underwritten  public
offering,  addressed to the  underwriters,  if any, and to the Holder and (ii) a
letter,  dated such date, from the independent  certified public  accountants of
the  Company,  in form and  substance  as is  customarily  given by  independent
certified public accountants to underwriters in an underwritten public offering,
addressed to the underwriters, if any, and to the Holder;

           (h)  make  available  for  inspection  by  Holder,   any  underwriter
participating in any distribution pursuant to such registration  statement,  and
any attorney,  accountant or other agent retained by such Holder or underwriter,
all financial and other records, pertinent corporate documents and properties of
the Company as shall be  reasonably  necessary to enable them to exercise  their
due diligence  responsibility,  and cause the Company's officers,  directors and
employees  to supply all  information  reasonably  requested by any such Holder,
underwriter,  attorney, accountant or agent in connection with such registration
statement;


           (i) use its best efforts to list all Registrable  Securities  covered
by such registration statement on NASDAQ or such other securities exchange where
the Company's  securities are then listed as may be mutually  agreed upon by the
parties and such securities exchange; and

           (j) The Company will cause any  restrictive  legend  imprinted on the
certificates  evidencing the Shares to be removed at such time as all conditions
to transfer of  restrictive  securities,  as  applicable  to such shares and the
holder  thereof  are  satisfied.  The  Company may require an opinion of counsel
reasonably   satisfactory  to  the  Company  to  support  the  removal  of  such
restrictive legend.


                                       6
<PAGE>

      1.11 Suspension of  Dispositions.  Holder agrees that, upon receipt of any
notice (a "Suspension Notice") from the Company of the happening of any event of
the kind which,  in the opinion of the counsel  for the  Company,  requires  the
amendment  or  supplement  of  any   prospectus,   such  Holder  will  forthwith
discontinue  disposition  of Registrable  Shares until  Holder's  receipt of the
copies of the  supplemented  or  amended  prospectus,  or until it is advised in
writing  by the  Company  that use of the  Prospectus  may be  resumed,  and has
received copies of any additional or supplemental filings which are incorporated
by reference in the prospectus,  and, if so directed by the Company, Holder will
deliver to the  Company  all  copies,  other than  permanent  file copies of the
Prospectus  covering such Registrable  Securities current at the time of receipt
of such notice.


INDEMNIFICATION

      1.12  Indemnification by the Company.  In the event of any registration of
any Registrable  Securities pursuant to this Agreement under the Securities Act,
the  Company   will,   and  hereby  does,   indemnify  and  hold  harmless  each
participating  Holder,  and  each of its  directors,  officers  and  controlling
persons, if any, against any losses,  claims,  damages or liabilities,  joint or
several,  to which  such  participating  Holder or any such  Person  may  become
subject under the Securities Act or otherwise,  insofar as such losses,  claims,
damages  or  liabilities  (or  actions  or  proceedings,  whether  commenced  or
threatened,  in  respect  thereof)  arise  out of or are based  upon any  untrue
statement or alleged  untrue  statement of any  material  fact  contained in the
registration  statement under which such Registrable  Securities were registered
under the  Securities  Act, any  preliminary  prospectus,  final  prospectus  or
summary prospectus contained therein, or any amendment or supplement thereto, or
any omission or alleged omission to state therein a material fact required to be
stated  therein or necessary  to make the  statements  therein,  in light of the
circumstances  under which they were made, not misleading,  and the Company will
reimburse  each  participating  Holder and each such  Person for any  reasonable
legal or any other expenses incurred by them in connection with investigating or
defending  any such loss,  claim,  liability,  action or  proceeding;  provided,
however,  that the  Company  shall not be liable in any such case to the  extent
that any such loss, claim, damage, liability (or action or proceeding in respect
thereof)  or  expense  arises  out of or is based  upon an untrue  statement  or
alleged  untrue   statement  or  omission  or  alleged  omission  made  in  such
registration  statement,  any such  preliminary  prospectus,  final  prospectus,
summary  prospectus,  amendment or supplement in reliance upon and in conformity
with written information furnished to the Company by any participating Holder or
any other Person who  participates  as an underwriter in the offering or sale of
such securities,  in either case, specifically stating that it is for use in the
preparation thereof; and provided, further, that the Company shall not be liable
to any  participating  Holder to the extent that any such loss,  claim,  damage,
liability (or action or proceeding in respect  thereof) or expense arises out of
such  participating  Holder's  failure  to  send  or  give a copy  of the  final
prospectus or supplement to the Persons asserting an untrue statement or alleged
untrue  statement  or  omission  or alleged  omission at or prior to the written
confirmation  of the  sale of  Registrable  Securities  to such  Person  if such
statement or omission was corrected in such final prospectus or supplement. Such
indemnity shall remain in full force and effect  regardless of any investigation
made by or on behalf of any  participating  Holder  or any such  underwriter  or
controlling  person and shall  survive the  transfer of such  securities  by the
Holder. 


                                       7
<PAGE>

      1.13 Indemnification by Participating  Holders.  Each of the participating
Holders  whose  Registrable  Securities  are  included  or to be included in any
registration  statement,  as a condition to including Registrable  Securities in
such registration statement,  agrees to indemnify and hold harmless (in the same
manner and to the same  extent as set forth in Section  5.1) the  Company,  each
director of the Company,  each officer of the Company who signs the registration
statement  and each other  Person,  if any, who controls the Company  within the
meaning of the  Securities  Act,  and each other Person who  participates  as an
underwriter in the offering or sale of such securities and each other Person who
controls  any such  underwriter  within the meaning of the  Securities  Act with
respect to any untrue  statement or alleged untrue  statement of a material fact
in or  omission  or  alleged  omission  to  state  a  material  fact  from  such
registration statement, any preliminary prospectus,  final prospectus or summary
prospectus  contained therein,  or any amendment or supplement  thereto, if such
untrue statement or alleged untrue statement or omission or alleged omission was
made in reliance upon and in conformity  with written  information  furnished to
the Company by any participating  Holder specifically stating that it is for use
in the preparation of such registration statement, preliminary prospectus, final
prospectus,  summary  prospectus,  amendment or supplement;  provided,  that the
liability of the Holders  hereunder  shall be limited to the  proportion  of any
such loss, claim, damage,  liability or expense which is equal to the proportion
that the public  offering  price of the shares sold by such Holder  bears to the
total public offering price of all securities sold pursuant to the  registration
statement, but not to exceed the proceeds (net of the underwriting discounts and
commissions) received by such Holder from such sale. Such indemnity shall remain
in full force and effect regardless of any investigation made by or on behalf of
the  Company  or  any  such  director,  officer,  or  any  such  underwriter  or
controlling  person and shall  survive the  transfer of such  securities  by any
participating Holder.

      1.14 Notices of Claims.  Promptly after receipt by an indemnified party of
notice  of the  commencement  of any  action  or  proceeding  involving  a claim
referred to in Section 5.1 or 5.2,  such  indemnified  party will, if a claim in
respect thereof is to be made against an indemnifying party, give written notice
to the latter of the commencement of such action;  provided,  however,  that the
failure of any  indemnified  party to give notice as provided  herein  shall not
relieve the  indemnifying  party of its  obligations  under  Section 5.1 or 5.2,
except to the extent that the indemnifying party is actually  prejudiced by such
failure  to give  notice.  In  case  any  such  action  is  brought  against  an
indemnified  party,  unless in such indemnified  party's  reasonable  judgment a
conflict of interest between such indemnified and indemnifying parties may exist
in  respect  of  such  claim,  the  indemnifying  party  shall  be  entitled  to
participate  in and to  assume  the  defense  thereof,  jointly  with any  other
indemnifying  party  similarly  notified  to the extent  that it may wish,  with
counsel reasonably satisfactory to such indemnified party, and after notice from
the indemnifying  party to such  indemnified  party of its election so to assume
the  defense  thereof,  the  indemnifying  party  shall  not  be  liable  to the
indemnified party for any legal or other expenses  subsequently  incurred by the
latter in connection  with the defense  thereof other than  reasonable  costs of
investigation;  provided  that the  indemnified  party may  participate  in such
defense at the indemnified  party's  expense;  and provided,  further,  that all
indemnified parties shall have the right to employ one counsel to represent them
if, in the reasonable judgment of such indemnified  parties, it is advisable for
them to be  represented  by separate  counsel by reason of having legal defenses
which are different from or in addition to those  available to the  indemnifying
party,  and in that event the  reasonable  fees and expenses of such one counsel
shall  be paid by the  indemnifying  party.  If the  indemnifying  party  is not
entitled  to, or elects not to,  assume the  defense of a claim,  it will not be
obligated  to pay the  fees  and  expenses  of more  than  one  counsel  for the
indemnified  parties  with  respect  to such  claim,  unless  


                                       8
<PAGE>

in the reasonable  judgment of any indemnified  party a conflict of interest may
exist  between such  indemnified  party and any other  indemnified  parties with
respect to such claim, in which event the indemnifying  party shall be obligated
to pay the fees and  expenses of such  additional  counsel  for the  indemnified
parties.  No indemnifying  party shall consent to entry of any judgment or enter
into any settlement  without the consent of the indemnified party which does not
include as an unconditional term thereof the giving by the claimant or plaintiff
to such  indemnified  party of a release  from all  liability in respect to such
claim or litigation. No indemnifying party shall be subject to any liability for
any settlement made without its consent, which consent shall not be unreasonably
withheld.

      1.15 Other Indemnification.  Indemnification  similar to that specified in
the preceding Sections of this Article V (with appropriate  modifications) shall
be given  by the  Company  and any  participating  Holder  with  respect  to any
required  registration or other qualification of securities under any federal or
state law or regulation of any governmental  authority other than the Securities
Act.

      1.16  Indemnification  Payments.  The  indemnification  required  by  this
Article V shall be made by periodic  payments of the amount  thereof  during the
course of the  investigation  or  defense,  as and when  bills are  received  or
expense, loss, damage or liability is incurred.

      1.17  Contribution.  If,  for  any  reason,  the  foregoing  indemnity  is
unavailable,  or is insufficient to hold harmless an indemnified party, then the
indemnifying  party  shall  contribute  to the  amount  paid or  payable  by the
indemnified  party as a result of the expense,  loss, damage or liability (a) in
such  proportion  as is  appropriate  to  reflect  the  relative  fault  of  the
indemnifying  party  on the one  hand and the  indemnified  party  on the  other
(determined  by reference to, among other things,  whether the untrue or alleged
untrue  statement of a material fact or omission or alleged  omission relates to
information  supplied by the indemnifying party or the indemnified party and the
parties'  relative intent,  knowledge,  access to information and opportunity to
correct or prevent such untrue statement or omission),  or (b) if the allocation
provided by clause (a) above is not  permitted by  applicable  law or provides a
lesser sum to the indemnified party than the amount otherwise payable hereunder,
in the  proportion as is  appropriate  to reflect not only the relative fault of
the indemnifying party and the indemnified party, but also the relative benefits
received by the indemnifying  party on the one hand and the indemnified party on
the  other,  as  well  as  any  other  relevant  equitable  considerations.   No
indemnified party guilty of fraudulent  misrepresentation (within the meaning of
Section 11(f) of the Securities Act) shall be entitled to contribution  from any
indemnifying party who was not guilty of such fraudulent misrepresentation.  The
liability  of the  holders  under  this  Section  5.6  shall be  limited  to the
proportion of any contribution  which is equal to the proportion that the public
offering  price of the  shares  sold by such  Holder  bears to the total  public
offering price of all securities sold pursuant to the registration statement but
not to exceed the  proceeds  (net of  underwriting  discounts  and  commissions)
received by such Holder from such sale.


INFORMATION BY PARTICIPATING HOLDERS

      1.18  Information  Regarding  Participating  Holders.  If any  Registrable
Securities are included in any  registration,  each  participating  Holder shall
furnish to the Company and any applicable underwriter such information regarding
such Holder and the distribution  proposed by such Holder as the Company or such
underwriter  may  reasonably


                                        9
<PAGE>

request in writing and as shall be required in connection with any registration,
qualification or compliance referred to in this Agreement.


TRANSFER OF RIGHTS

      1.19 Transfer or Assignment.  The rights granted  hereunder by the Company
may be assigned or otherwise  conveyed to the Permitted  Transferees  of KMD. It
shall be a condition to any Transfer that (a) the Company shall have received an
opinion of counsel reasonably acceptable to it that such Transfer is effected in
accordance  with  applicable   federal  and  state  securities  laws,  (b)  such
transferee or assignee becomes a party to this Agreement or agrees in writing to
be  subject  to the  terms  hereof to the same  extent as if it were the  Holder
hereunder, and (c) the Company is given written notice of said Transfer, stating
the name and address of said  transferee and  identifying  the  securities  with
respect to which such registration rights are being assigned.


TERMINATION

      1.20 Termination.  This Agreement and the rights provided  hereunder shall
terminate  and be of no further  force and effect with respect to each Holder on
such date as such Holder no longer holds any Registrable Securities.


MISCELLANEOUS

      1.21 Remedies for Breach.  It is expressly  understood  that the equitable
remedies of specific  performance  and  injunction  shall be  available  for the
enforcement of the covenants and agreements herein, and that the availability of
these equitable  remedies shall not be deemed to limit any other right or remedy
to  which  any  party  to this  Agreement  would  otherwise  be  entitled.  

      1.22 Successors and Assigns. Subject to the provisions of Section 7.1, the
terms and  conditions  of this  Agreement  shall  inure to the benefit of and be
binding upon the respective successors,  assigns and transferees of the parties.
If any successor, assignee or transferee of any Holder shall acquire Registrable
Securities,  in any  manner,  whether by  operation  of law or  otherwise,  such
Registrable  Securities  shall  be  held  subject  to all of the  terms  of this
Agreement,  and by taking and holding such  Registrable  Securities  such Person
shall be conclusively  deemed to have agreed to be bound by all of the terms and
provisions hereof.

      1.23 Notices. All notices and other communications  provided for hereunder
shall be in writing and sent by registered  or certified  mail,  return  receipt
requested,  postage prepaid or delivered in person or by courier,  telecopier or
electronic  mail, and shall be deemed to have been duly given when received,  by
the party to whom such notice is to be given at its address set forth below,  or
at such  other  address  for the party as shall be  specified  by  notice  given
pursuant hereto:



            if to the Company, to:


                                       10
<PAGE>


                  DIANON Systems, Inc.
                  200 Watson Boulevard
                  Stratford, Connecticut 06409
                  Attention:  Chief Executive Officer
                  Fax:  (203) 380-4138

            with a copy to:

                  Cadwalader, Wickersham & Taft
                  100 Maiden Lane
                  New York, NY 10038
                  Attention:  Dennis J.  Block, Esq.
                  Fax:  (212) 504-5557

            If to a Holder,  to such  Holder at the  address  set forth for such
Holder in the stock records of the Company.  

      1.24 Governing  Law. This  Agreement and any  controversy or claim arising
out of or relating to this Agreement  shall be governed by the laws of the State
of New York, without giving effect to the principles of conflicts of laws.

      1.25 Entire Agreement;  Amendments and Waivers. This Agreement constitutes
the entire  agreement among the parties  pertaining to the subject matter hereof
and  supersedes  all  prior   agreements,   understandings,   negotiations   and
discussions whether oral or written, of the parties. No supplement, modification
or waiver of this Agreement  shall be binding unless  executed in writing by all
parties. No waiver of any of the provisions of this Agreement shall be deemed or
shall  constitute  a  waiver  of any  other  provision  hereof  (whether  or not
similar),  nor shall such waiver constitute a continuing waiver unless otherwise
expressly provided.

      1.26  Counterparts.  This  Agreement  may  be  executed  in  two  or  more
counterparts,  each of  which  shall be  deemed  an  original,  but all of which
together  shall  constitute  one and the same  instrument.  Copies  of  executed
counterparts  transmitted by telecopy or other electronic  transmission  service
shall be considered original executed  counterparts for purposes of this Section
9.6.

      1.27  Severability.  In the event  that any one or more of the  provisions
contained  in this  Agreement  shall,  for any  reason,  be held to be  invalid,
illegal  or  unenforceable  in  any  respect,  such  invalidity,  illegality  or
unenforceability shall not affect any other provision of this Agreement.

      1.28  Headings.  The  headings of the  Articles  and  Sections  herein are
inserted for convenience of reference only and are not intended to be part of or
to affect the meaning or interpretation of this Agreement.

      1.29 Gender and Other  References.  Unless the context  clearly  indicates
otherwise,  the use of any gender pronoun in this  Agreement  shall be deemed to
include all other genders,  and singular references shall include the plural and
vice versa.

                           [SIGNATURE PAGE FOLLOWS]


                                       11
<PAGE>



            IN  WITNESS   WHEREOF,   the  parties   hereto  have  executed  this
Registration Rights Agreement as of the day and year first above written.


                                       DIANON SYSTEMS, INC.



                                          By:  /s/  Kevin C. Johnson
                                             -----------------------
                                          Name:  Kevin C. Johnson
                                          Title:  President & CEO


                                       KYTO MERIDIEN DIAGNOSTICS, L.L.C.



                                          By:
                                          /s/ Ralph M. Richart
                                          ----------------------------
                                          Name:  Ralph M. Richart
                                          Title:  President of General
                                          Partner of Member






                                       12




                                                                  EXHIBIT 10.3

                             CONSULTING AGREEMENT


      THIS IS A CONSULTING  AGREEMENT  ("Agreement") made and entered into as of
the 1st day of May,  1999,  by and  between  DIANON  Systems,  Inc.,  a Delaware
corporation ("DIANON"), and A. Bruce Shapiro ("Shapiro").

                                  RECITALS:

      WHEREAS,  DIANON has acquired substantially all of the assets and business
of Kyto  Meridien  Diagnostics,  L.L.C.,  a New York limited  liability  company
("Kyto Meridien"), pursuant to the terms of an Asset Purchase Agreement dated as
of April 7, 1999, by and among DIANON,  Kyto Meridien,  Kyto Diagnostics,  L.P.,
Meridien Diagnostics Labs, Inc., Shapiro and Ralph M.
Richart, M.D. (the "Asset Purchase Agreement"); and

      WHEREAS,  DIANON desires to retain  Shapiro for a period  commencing as of
the Closing Date  ("Closing  Date") of the Asset  Purchase  Agreement and ending
three years from that date and  Shapiro  desires to be so retained by DIANON for
such period on the terms and conditions hereinafter provided; and

      WHEREAS, Shapiro's position with Kyto Meridien has given him access to and
familiarity  with the  confidential  information  and business of Kyto  Meridien
acquired by DIANON and his consultation  with DIANON will give him access to and
familiarity with the confidential information and business of DIANON; and

      WHEREAS, DIANON would be irreparably harmed if Shapiro should disclose any
of the confidential  information  which Shapiro has acquired and will acquire or
by entering  into any  activity  competing  with DIANON or the  business of Kyto
Meridien acquired by DIANON.

      NOW,  THEREFORE,  in  consideration  of the  mutual  covenants,  terms and
conditions of this Agreement, Shapiro and DIANON agree as follows:

      1.    CONSULTATION.  DIANON hereby  retains the services of Shapiro to aid
in the transition (including, without limitation, assuring the timely payment of
accounts  payable and current  liabilities  retained by Sellers under Subsection
2(e) of the Asset  Purchase  Agreement)  and  stabilization  and to  advise  and
consult with respect to the growth of the business  acquired by DIANON  pursuant
to the Asset  Purchase  Agreement  and to advise and consult in such other areas
within his experience, knowledge and expertise. Such services shall be performed
by Shapiro in person at DIANON's  facility in  Woodbury  New York,  or, with his
consent,  at  its  headquarters  in  Connecticut.  Shapiro  shall  make  himself
available to DIANON for the  performance  of such services no more than two days
per week  forty-eight  weeks per year as  requested  by DIANON  during  the term
hereof.  In providing  such  consulting  services,  Shapiro  shall in good faith
render advice and provide  information to DIANON,  fully reflecting the range of
his knowledge,  information and experience in the areas of consultation.  During
the term of this  Agreement,  Shapiro  shall at all times  conduct  himself  and
perform his services in a proficient and professional manner, in accordance with
the applicable standards of care and the highest standards of ethics.


<PAGE>

      2.   COMPENSATION.   As full  consideration  for the services  rendered by
Shapiro  pursuant  to  this  Agreement,  together  with  Shapiro's  undertakings
pertaining to the  preservation of confidential  information and the restrictive
covenant  set forth,  respectively,  in  Sections 4 and 5 below,  DIANON  shall,
during the term of this Agreement, compensate Shapiro as follows:

            (a)  _DIANON shall render  monthly  payments of nineteen  thousand
three hundred and nineteen ($19,319) dollars to Shapiro.;

            (b)   DIANON  shall  reimburse the reasonable  business  expenses of
Shapiro in  performing  his duties  hereunder in  accordance  with such policies
regarding expenses as DIANON may have in effect from time to time;

            (c)   At no cost to Shapiro,  DIANON shall, for a period of at least
six  months  from and after the  Closing  Date,  make  available  for the use of
Shapiro his current office  located at 40 Crossways Park Drive in Woodbury,  New
York; provided that DIANON may terminate such rights effective at any time after
such six month period by the provision of three month's prior written notice.

      3.    TERM.   Unless sooner terminated in accordance with Section 9 below,
the term of this  Agreement  shall  commence  on the  Closing  Date of the Asset
Purchase Agreement and end on the third anniversary thereof.

      4.    CONFIDENTIAL  INFORMATION.  From and after the date hereof,  Shapiro
will not,  directly  or  indirectly,  use for his own  benefit or  purposes,  or
disclose  to, or use for the  benefit or  purpose of any person or entity  other
than DIANON,  any  confidential  information,  knowledge or data relating to the
business or operations of DIANON or those acquired by DIANON from Kyto Meridien.
Such information,  knowledge or data includes,  but is not limited to, secret or
confidential  matters not published or generally known in the industry,  such as
information regarding pricing, costs, purchasing,  profits, financing,  markets,
sales  or  customer  lists,   future   developments,   audits,   investigations,
enforcement actions, regulatory compliance,  laboratory procedures and marketing
and expansion  plans.  Any and all materials which may be produced or created by
Shapiro or others,  or which may come into his  possession  in the course of his
employment,  or which  relate  in any  manner  to the  business  or  prospective
business of DIANON are and shall be the exclusive property of DIANON and Shapiro
shall  not have  any  right,  title or  interest  in any  such  materials.  Upon
termination  of his  employment,  Shapiro shall not have the right to remove any
such materials  from the offices of DIANON and shall  promptly  return to DIANON
all things of whatever nature that belong to DIANON, including all materials and
records in any form,  format or medium containing or related to the confidential
information  of DIANON,  and he shall  neither  make nor retain any part or copy
thereof for his personal use or the use of third parties.

            Notwithstanding  the foregoing,  confidential  information shall not
include any information  that is: (i)  demonstrably  developed  independently by
Shapiro;  (ii)  publicly  disclosed by DIANON or otherwise in the public  domain
without violation of this Agreement by Shapiro;  or (iii) rightfully received by
Shapiro from a third party, which, by disclosing to Shapiro, does not breach any
obligation or duty to DIANON.  Notwithstanding  this Section 4, Shapiro may make
such  disclosures  of  confidential  information  as are duly compelled by court
order or as required by law.


                                       2
<PAGE>

      5.    RESTRICTIVE  COVENANT.  In  consideration  of this Agreement and the
purchase of the assets and business of Kyto Meridien by DIANON,  for a period of
three  years  from and  after the  Closing  Date and for any  renewal  period or
extension of the term hereof,  and  notwithstanding  any earlier  termination of
this Agreement, except upon the express written consent of DIANON (which consent
may be unreasonably withheld), Shapiro shall not, for his own account, on behalf
of, or jointly with,  any other person,  directly or  indirectly,  own,  manage,
operate,  join,  control,  finance,  invest in, perform services for, advise (or
advise  others with respect to), or  otherwise  participate  in, or be connected
with,  or  become  or act as a  partner,  manager,  member,  director,  officer,
employee,  consultant,  representative  or agent  of any  business  (other  than
DIANON), individual,  partnership, firm, proprietorship,  professional practice,
corporation,  limited  liability  company or other entity that provides clinical
laboratory or anatomic or surgical  pathology  services within a one hundred and
fifty mile radius of New York City; provided however,  that Shapiro may purchase
or own,  solely as an inactive  investor,  the  securities of any entity that is
publicly  traded on a national  securities  exchange where  Shapiro's  aggregate
holdings of such  securities do not exceed two percent of the voting power or of
any class of stock of such entity.

      In addition to the foregoing,  during the same  three-year  period and for
any renewal  period or extension of the term hereof,  Shapiro  shall not, on his
own  behalf,  or on behalf  of any  other  person or  entity:  (i)  solicit  the
customers,  suppliers  or  employees of DIANON or any  affiliated  entity;  (ii)
solicit or seek to hire any  employee  of DIANON or any  affiliated  entity;  or
(iii) attempt in any manner,  directly or  indirectly,  to influence,  induce or
encourage any such employee to leave the  employment of DIANON or any affiliated
entity.  Shapiro shall not take any action intended,  or which may reasonably be
expected,  directly or  indirectly,  to impair the goodwill,  reputation or good
name of DIANON or Kyto Meridien, or otherwise to be detrimental to the interests
of DIANON,  including any action intended,  or which may reasonably be expected,
directly or indirectly, to benefit a competitor of DIANON.

      6.    SCOPE  OF  RESTRICTIONS.  Shapiro agrees that the  restrictions  set
forth in Section 5 are  reasonable.  If,  however,  a court  determines that any
provision of Section 5 is unreasonable,  either in geographic  scope,  length of
time or  otherwise,  then  Section 5 shall be  interpreted  and  enforced to the
maximum extent  permitted by law and Shapiro consents and agrees that such scope
may be judicially modified accordingly in any proceeding brought to enforce such
restriction.

      7.    INJUNCTIVE  RELIEF. Shapiro acknowledges that irreparable harm would
be suffered by DIANON in the event that any of the provisions of Sections 4 or 5
were not performed fully in accordance with the terms specified therein and that
monetary  damages are an  inadequate  remedy for breach  thereof  because of the
difficulty of  ascertaining  and  quantifying  the amount of damage that will be
suffered  by DIANON in the event  that such  undertakings  and  provisions  were
breached or violated. Accordingly,  Shapiro agrees that DIANON shall be entitled
to an  injunction or  injunctions  to restrain,  enjoin and prevent  breaches or
threatened  breaches of the  covenants,  undertakings  and  provisions  of those
sections and to enforce  specifically the provisions therein in any court of the
United  States  or any  state  having  jurisdiction  over the  matter,  it being
understood  that any such remedies  shall be in addition to, and not in lieu of,
any other  rights and  remedies  available  at law or in equity and shall not be
deemed  exclusive of any common law or other rights of DIANON in connection with
the matters covered hereby.


                                       3
<PAGE>

      8.    INTELLECTUAL  PROPERTY RIGHTS.  Shapiro agrees to assign, and hereby
does  assign to  DIANON,  all of his  right,  title and  interest  in and to all
inventions, improvements, discoveries and technical developments, whether or not
patentable,  which he solely or jointly with others,  may  conceive,  develop or
reduce to practice  during the term of this  Agreement,  which are  related,  in
whole or in part,  directly or  indirectly,  to the  business of, or services or
products of the type, provided by DIANON, or which may reasonably be provided or
used by  DIANON,  or which  are  otherwise  developed,  in whole or in part,  at
DIANON's expense.

      Shapiro shall disclose promptly to DIANON's Chief Executive  Officer,  all
such  ideas,   discoveries  and  improvements  conceived  by  him  alone  or  in
collaboration with others, and shall cooperate fully with DIANON both during and
after the term of this Agreement, with respect to the procurement of patents for
the  establishment  and  maintenance  of DIANON's  rights and  interests in said
inventions, improvements, discoveries or developments, and shall sign all papers
which DIANON may  reasonably  deem  necessary  or  desirable  for the purpose of
vesting it with such rights.

      9.    TERMINATION.      (a)  This  Agreement   shall  terminate  on  the
occurrence of any of the following events:

            (i)   Upon the death of Shapiro;

            (ii)  Upon  the sending of written notice from DIANON describing the
activities  constituting an act of default falling within any one or more of the
following categories:

                  (A) Shapiro's  breach of any material promise or agreement set
                  forth herein, including,  without limitation,  those set forth
                  in  Sections  4, 5 and 8  above,  or his  failure  to  provide
                  substantially  all  of the  services  reasonably  required  by
                  Section 1; or

                  (B)  Shapiro's  commission  of an act of gross  negligence  or
                  willful  misconduct,  or acts showing a pattern of negligence,
                  in the performance of his services or obligations hereunder or
                  otherwise injurious to DIANON;

Provided  that no such  termination  under  this  subsection  9(a)(ii)  shall be
effective  unless  Shapiro has first been afforded an opportunity to correct the
alleged  default,  but such default  continues,  recurs or can not  otherwise be
corrected,  in the good faith  judgment  of  DIANON,  within  thirty  days after
delivery of such written notice of default to Shapiro;

            (iii) Upon  the  occurrence of an event or the  commission of an act
under  which  Shapiro  is or may  become  subject  to  mandatory  or  permissive
exclusion  from  Medicare and State health care  programs,  including  those set
forth  in  sections  1128,  1156  and 1892 of the  Social  security  Act and any
regulations promulgated thereunder; and

            (iv)  Upon  the passage of thirty (30) days after written  notice of
termination without cause from DIANON to Shapiro.


                                       4
<PAGE>

      (b)   In  the  event  of a  termination  of  this  Agreement  pursuant  to
subsections  9(a)(i)  or  9(a)(iv)  above,  DIANON  shall  continue  to pay  the
compensation set forth in Section 2(a) above until the third  anniversary of the
Closing Date of the Asset Purchase Agreement.

      (c)   Sections  4, 5, 6, 7, 12 and 14 of this Agreement shall survive,  in
accordance with their terms,  any  termination of this  Agreement,  whether such
termination  be with or without cause.  No  termination of this Agreement  shall
relieve  Shapiro of his  obligations  to DIANON with respect to the  restrictive
covenant in Section 5 and the  preservation  of confidential  information  under
Section 4. Should Shapiro violate any of the  requirements of Sections 4 or 5 of
this Agreement, DIANON may, in addition to any other remedies provided to DIANON
under this  Agreement,  at law or in equity,  immediately  terminate any further
post-termination  payments to Shapiro  hereunder  that  otherwise  may have been
required.

      10.   INDEPENDENT  CONTRACTOR.   Shapiro's  services  hereunder  shall  be
rendered in the capacity of an independent  contractor of DIANON, and Shapiro is
not in any respect or circumstances  an employee of DIANON.  Neither Shapiro nor
DIANON has the authority to enter into contracts or assume any  obligations  for
or on behalf of the other or to make any warranties or representations for or on
behalf of the other.  Shapiro shall be solely  responsible for any taxes imposed
on the  performance  of  his  consulting  services  or  the  payment  therefore,
including  withholding  of state and federal  income or estimated  tax payments,
sales or ad valorem taxes,  unemployment  compensation,  worker's  compensation,
obligations under the Federal Insurance  Contributions Act, Federal Unemployment
Tax Act and other taxes,  costs and expenses  incurred in the performance of his
engagement  hereunder,   except  as  expressly  assumed  by  DIANON  under  this
Agreement. Shapiro expressly indemnifies and holds DIANON harmless from any such
liabilities.

      11.   WAIVER.  The  failure  of  either  party  at  any  time  to  require
performance  by the other party of any provision  hereof shall not affect in any
way the full right to require such performance at any time thereafter, nor shall
a waiver by either party of a breach of any provision hereof be taken or held to
be a waiver of the provision itself.

      12.   NOTICES.  All notices,  requests,  demands and other  communications
hereunder  shall be in  writing  and shall be deemed to have been duly  given if
delivered by hand, by  nationally  recognized  overnight  delivery  service,  or
mailed by  certified or  registered  mail,  postage  prepaid,  and  addressed as
follows:

            If to Shapiro:    A. Bruce Shapiro
                              40 Juneau Boulevard
                              Woodbury, New York 11797


            If to DIANON:     DIANON Systems, Inc.
                              200 Watson Boulevard
                              Stratford, Connecticut  06497
                              Attn: President

      13.   ENTIRE  AGREEMENT.  This Agreement and the Asset Purchase  Agreement
set forth the entire agreement and  understanding of the parties  concerning the
subject  matter  hereof.  


                                       5
<PAGE>

This  Agreement  may be  amended  only by a  written  instrument  signed by both
parties, which instrument must make specific reference to this Agreement and the
intention to modify it.

      14.   GOVERNING  LAW. This Agreement shall be governed by and construed in
accordance  with the laws of the  State of New  York  without  reference  to the
conflicts of laws provisions of that state.


      IN WITNESS WHEREOF, the parties have executed this Agreement as of the day
first above written.


                                          /s/ A. Bruce Shapiro
                                          --------------------
                                          A. Bruce Shapiro


                                          DIANON SYSTEMS, INC.

                                          /s/ Kevin C. Johnson
                                          --------------------
                                          By: Kevin C. Johnson
                                          Its:  President & CEO




                                       6





                                                                  EXHIBIT 10.4

                             EMPLOYMENT AGREEMENT



      THIS IS AN EMPLOYMENT  AGREEMENT  ("Agreement") made and entered into as
of the 1st day of May, 1999, by and between DIANON  Systems,  Inc., a Delaware
corporation ("DIANON"), and Ralph M. Richart, M.D. ("Richart").

                                  RECITALS:

      WHEREAS,  DIANON has acquired substantially all of the assets and business
of Kyto  Meridien  Diagnostics,  L.L.C.,  a New York limited  liability  company
("Kyto Meridien"), pursuant to the terms of an Asset Purchase Agreement dated as
of April 7, 1999, by and among DIANON,  Kyto Meridien,  Kyto Diagnostics,  L.P.,
Meridien  Diagnostics  Labs,  Inc.,  Richart  and A. Bruce  Shapiro  (the "Asset
Purchase Agreement"); and

      WHEREAS,  DIANON desires to employ  Richart for a period  commencing as of
the Closing Date  ("Closing  Date") of the Asset  Purchase  Agreement and ending
three  years  from that date and  Richart  desires  to work for  DIANON for such
period on the terms and conditions hereinafter provided; and

      WHEREAS, Richart's position with Kyto Meridien has given him access to and
familiarity  with the  confidential  information  and business of Kyto  Meridien
acquired  by DIANON and his  employment  with DIANON will give him access to and
familiarity with the confidential information and business of DIANON; and

      WHEREAS, DIANON would be irreparably harmed if Richart should disclose any
of the confidential  information  which Richart has acquired and will acquire or
by entering  into any  activity  competing  with DIANON or the  business of Kyto
Meridien acquired by DIANON.

      NOW,  THEREFORE,  in  consideration  of the  mutual  covenants,  terms and
conditions of this Agreement, Richart and DIANON agree as follows:

      1.    EMPLOYMENT.  DIANON  hereby  employs  Richart  for the  term of this
Agreement as specified in Section 3, below.  Richart's duties shall include: (i)
service,  for a period of one year from and after the Closing Date, as statutory
Laboratory  Director  at the  laboratory  facility  acquired by DIANON from Kyto
Meridien located at 216 Congers Road in New City, New York,  provided,  however,
that Richart's  responsibilities  in that regard shall be no greater in terms of
quantity  or  substance  than  those held at Kyto  Meridien  during the one year
period immediately preceding the Closing Date and provided further that he shall
not, except to the extent required by law or regulation, have responsibility for
the day-to-day  oversight or management of the laboratory;  (ii) for a period of
at least six months from and after the Closing Date,  performance of a volume of
surgical  and  anatomic  pathology  and  cytology   examinations  and  diagnoses
consistent with his workload while employed by Kyto Meridien and, thereafter, at
a reduced volume as mutually agreed; (iii) while serving as Laboratory Director,
performance of all requirements of a laboratory  director  specified under CLIA,
New  York  State  law and  other  federal,  state  and  local  laws,  rules  and
regulations;  (iv)  occasional  rendering of decisions  on  significant  medical
matters  and other  matters  materially  impacting  on  medical  decisions;  (v)


<PAGE>

rendering,  as needed,  professional  advice to clients,  as well as written and
telephonic responses to client inquiries regarding test results or other medical
inquiries;  (vi) preparing client  communications and newsletters on medical and
laboratory  issues;  (vii) upon mutual  agreement,  attendance  and  delivery of
presentations   at   professional   meetings   and   conferences   as   DIANON's
representative;  and (vii) such other tasks and  assignments  that are  mutually
agreed to at the request of the senior management of DIANON.

      It is  expressly  agreed and  understood  that the above  duties  shall be
performed  by Richart on a good faith basis  subject to an  academic  and travel
schedule  commensurate  with his schedule in the one year immediately  preceding
the Closing Date.  Under no  circumstances  shall the  performance of any duties
herein  exceed  those  performed  by  Richart  during  the one year  immediately
preceding  the Closing Date in quantity or  substance  and,  further,  except as
required by law or  regulation,  such  performance  does not  require  Richart's
on-site  presence  other than on an incidental  basis.  DIANON further agrees to
make reasonable efforts to ensure that, during the term of this Agreement, there
will be  adequate  personnel  and  consultants  available  to assist and support
Richart in the performance of his duties hereunder.

      During his  employment  Richart  shall at all times  conduct  himself  and
perform his professional  services in a proficient and professional  manner,  in
accordance  with the applicable  standards of care and the highest  standards of
ethics of the medical profession.

      2.    COMPENSATION.  As full  consideration  for the services  rendered by
Richart  pursuant  to  this  Agreement,  together  with  Richart's  undertakings
pertaining to the  preservation of confidential  information and the restrictive
covenant  set forth,  respectively,  in  Sections 4 and 5 below,  DIANON  shall,
during the term of this Agreement, compensate Richart as follows:

            (a)   DIANON  shall pay Richart an annualized  salary of two hundred
thousand ($200,000) dollars, payable in twenty-six equal biweekly (one every two
weeks)  increments,  of  seven  thousand  six  hundred  ninety-two  dollars  and
thirty-one cents ($7,692.31);

            (b)   DIANON  shall  reimburse the reasonable  business  expenses of
Richart in  performing  his duties  hereunder in  accordance  with such policies
regarding  employee  expenses  as DIANON  may have in  effect  from time to time
during the term;

            (c)   DIANON shall provide  Richart with an  automobile  allowance
of five hundred and sixty-nine ($569) dollars per month;

            (d)   Richart  shall be eligible for such other employee benefits as
are  generally  provided  by DIANON to its  employees  subject  to the terms and
conditions, including eligibility conditions, of any applicable employee benefit
plan or program;  provided that,  during the period of employee  conversion,  as
determined by DIANON  consistent  with the  requirements  of the Asset  Purchase
Agreement,  Richart  shall be entitled to such Kyto  Meridien  benefits that are
required by the Asset  Purchase  Agreement  to be extended to all Kyto  Meridien
employees hired by DIANON.

            (e)   Upon  termination of employment,  Richart may, at his own cost
and in accordance with the requirements of COBRA,  extend his employee insurance
benefits.


                                       2
<PAGE>

      3.    TERM.   Unless sooner terminated in accordance with Section 9 below,
the term of this  Agreement  and  Richart's  employment  shall  commence  on the
Closing Date of the Asset  Purchase  Agreement and end on the third  anniversary
thereof.

      4.    CONFIDENTIAL  INFORMATION.  From and after the date hereof,  Richart
will not,  directly  or  indirectly,  use for his own  benefit or  purposes,  or
disclose  to, or use for the  benefit or  purpose of any person or entity  other
than DIANON,  any  confidential  information,  knowledge or data relating to the
business or operations of DIANON or those acquired by DIANON from Kyto Meridien.
Such information,  knowledge or data includes,  but is not limited to, secret or
confidential  matters not published or generally known in the industry,  such as
information regarding pricing, costs, purchasing,  profits, financing,  markets,
sales  or  customer  lists,   future   developments,   audits,   investigations,
enforcement actions, regulatory compliance,  laboratory procedures and marketing
and expansion  plans.  Any and all materials which may be produced or created by
Richart or others,  or which may come into his  possession  in the course of his
employment,  or which  relate  in any  manner  to the  business  or  prospective
business of DIANON are and shall be the exclusive property of DIANON and Richart
shall  not have  any  right,  title or  interest  in any  such  materials.  Upon
termination  of his  employment,  Richart shall not have the right to remove any
such materials  from the offices of DIANON and shall  promptly  return to DIANON
all things of whatever nature that belong to DIANON, including all materials and
records in any form,  format or medium containing or related to the confidential
information  of DIANON,  and he shall  neither  make nor retain any part or copy
thereof for his personal use or the use of third parties.

            Notwithstanding  the foregoing,  confidential  information shall not
include any information  that is: (i)  demonstrably  developed  independently by
Richart;  (ii)  publicly  disclosed by DIANON or otherwise in the public  domain
without violation of this Agreement by Richart;  or (iii) rightfully received by
Richart from a third party, which, by disclosing to Richart, does not breach any
obligation or duty to DIANON.  Notwithstanding  this Section 4, Richart may make
such  disclosures  of  confidential  information  as are duly compelled by court
order or as required by law.

      5.    RESTRICTIVE  COVENANT.  In  consideration  of this Agreement and the
purchase of the assets and business of Kyto Meridien by DIANON,  for a period of
three  years  from and  after the  Closing  Date and for any  renewal  period or
extension of the term hereof,  and  notwithstanding  any earlier  termination of
this Agreement, except upon the express written consent of DIANON (which consent
may be unreasonably withheld), Richart shall not, for his own account, on behalf
of, or jointly with,  any other person,  directly or  indirectly,  own,  manage,
operate,  join,  control,  finance,  invest in, perform services for, advise (or
advise  others with respect to), or  otherwise  participate  in, or be connected
with,  or  become  or act as a  partner,  manager,  member,  director,  officer,
employee,  consultant,  representative  or agent  of any  business  (other  than
DIANON), individual,  partnership, firm, proprietorship,  professional practice,
corporation,  limited  liability  company or other entity that provides clinical
laboratory or anatomic or surgical  pathology  services within a one hundred and
fifty mile radius of New York City; provided however,  that Richart may purchase
or own,  solely as an inactive  investor,  the securities of any entity that are
publicly  traded on a national  securities  exchange where  Richart's  aggregate
holdings of such  securities do not exceed two percent of the voting power or of
any class of stock of such entity.


                                       3
<PAGE>

      Notwithstanding anything to the contrary herein, Richart may continue: (i)
in his academic post at the Columbia College of Physicians and Surgeons; (ii) in
his  position  as  the  Associate  Director  of  Obstetrical  and  Gynecological
Pathology and Cytology at Columbia  Presbyterian  Medical  Center;  and (iii) to
participate,  from time to time,  as a consultant  in research  studies (but not
clinical  trials)  relating to clinical and surgical  pathology,  provided  that
Richart  shall not act as a  consultant  in  research  studies  for any  medical
laboratory.

            In addition to the foregoing,  during the same three-year period and
for any renewal  period or extension of the term hereof,  Richart  shall not, on
his own  behalf,  or on behalf of any other  person or entity:  (i)  solicit the
customers,  suppliers  or  employees of DIANON or any  affiliated  entity;  (ii)
solicit or seek to hire any  employee  of DIANON or any  affiliated  entity;  or
(iii) attempt in any manner,  directly or  indirectly,  to influence,  induce or
encourage any such employee to leave the  employment of DIANON or any affiliated
entity.  Richart shall not take any action intended,  or which may reasonably be
expected,  directly or  indirectly,  to impair the goodwill,  reputation or good
name of DIANON or Kyto Meridien, or otherwise to be detrimental to the interests
of DIANON,  including any action intended,  or which may reasonably be expected,
directly or indirectly to benefit a competitor of DIANON.

      6.    SCOPE  OF  RESTRICTIONS.  Richart agrees that the  restrictions  set
forth in Section 5 are  reasonable.  If,  however,  a court  determines that any
provision of Section 5 is unreasonable,  either in geographic  scope,  length of
time or  otherwise,  then  Section 5 shall be  interpreted  and  enforced to the
maximum extent  permitted by law and Richart consents and agrees that such scope
may be judicially modified accordingly in any proceeding brought to enforce such
restriction.

      7.    INJUNCTIVE  RELIEF. Richart acknowledges that irreparable harm would
be suffered by DIANON in the event that any of the provisions of Sections 4 or 5
were not performed fully in accordance with the terms specified therein and that
monetary  damages are an  inadequate  remedy for breach  thereof  because of the
difficulty of  ascertaining  and  quantifying  the amount of damage that will be
suffered  by DIANON in the event  that such  undertakings  and  provisions  were
breached or violated. Accordingly,  Richart agrees that DIANON shall be entitled
to an  injunction or  injunctions  to restrain,  enjoin and prevent  breaches or
threatened  breaches of the  covenants,  undertakings  and  provisions  of those
sections and to enforce  specifically the provisions therein in any court of the
United  States  or any  state  having  jurisdiction  over the  matter,  it being
understood  that any such remedies  shall be in addition to, and not in lieu of,
any other  rights and  remedies  available  at law or in equity and shall not be
deemed  exclusive of any common law or other rights of DIANON in connection with
the matters covered hereby.

      8.    INTELLECTUAL  PROPERTY RIGHTS.  Richart agrees to assign, and hereby
does  assign to  DIANON  all of his  right,  title  and  interest  in and to all
inventions, improvements, discoveries and technical developments, whether or not
patentable,  which he solely or jointly with  others,  may conceive or reduce to
practice  during the term of his employment,  which are related,  in whole or in
part, directly or indirectly, to the business of, or services or products of the
type, provided by DIANON, or which may reasonably be provided or used by DIANON,
or which are otherwise developed, in whole or in part, at DIANON's expense.

      Richart shall disclose promptly to DIANON's Chief Executive  Officer,  all
such  ideas,   discoveries  and  improvements  conceived  by  him  alone  or  in
collaboration with others, and shall 


                                       4
<PAGE>

cooperate  fully with DIANON both during and after  employment,  with respect to
the  procurement of patents for the  establishment  and  maintenance of DIANON's
rights  and  interests  in  said   inventions,   improvements,   discoveries  or
developments,  and shall  sign all  papers  which  DIANON  may  reasonably  deem
necessary or desirable for the purpose of vesting it with such rights.

      9.    TERMINATION.      (a) Richart's  employment  under this  Agreement
shall terminate on the occurrence of any of the following events:

            (i)   Upon the  disqualification  of Richart to practice  medicine
in the State of New York;

            (ii)  Upon  the  disqualification  of  Richart,  or his  failure  to
maintain all  necessary  licenses and  certifications,  to serve as a laboratory
director in the State of New York,  while  serving as a Laboratory  Director for
DIANON;

            (iii) Upon the death of Richart;

            (iv)  Upon  the passage of thirty (30) days after written  notice of
termination without cause from DIANON to Richart;

            (v)   Upon  the sending of written notice from DIANON describing the
activities  constituting an act of default falling within any one or more of the
following categories:

                  (A)   Richart's  breach of any  material  promise or agreement
                        set forth herein, including,  without limitation,  those
                        set forth in  Sections  4, 5 and 8 above,  or failure to
                        perform  substantially  all  of  the  duties  reasonably
                        required by Section 1; or

                  (B)   Richart's  commission  of an act of gross  negligence or
                        willful  misconduct in the  performance of his duties or
                        obligations  hereunder  or an act of  negligence  in the
                        performance of a medical function;

Provided  that no such  termination  under  this  subsection  9(a)(v)  shall  be
effective  unless  Richart has first been afforded an opportunity to correct the
alleged  default,  but such default  continues,  recurs or can not  otherwise be
corrected,  in the good faith  judgment  of  DIANON,  within  thirty  days after
delivery of such written notice of default to Richart; and

            (vi)  Upon  the  occurrence of an event or the  commission of an act
under  which  Richart  is or may  become  subject  to  mandatory  or  permissive
exclusion  from  Medicare and State health care  programs,  including  those set
forth  in  sections  1128,  1156  and 1892 of the  Social  security  Act and any
regulations promulgated thereunder.

      (b)   In  the  event  of a  termination  of  this  Agreement  pursuant  to
subsections  9(a)(iii)  or  9(a)(iv)  above,  DIANON  shall  continue to pay the
compensation  required  by  subsections  2(a) and 2(c)  above  until  the  third
anniversary of the Closing Date of the Asset Purchase Agreement.


                                       5
<PAGE>

      (c)   Sections  4, 5, 6, 7,  11,  13 and 14 of this  Agreement  shall,  in
accordance  with their terms,  survive any  termination  or  expiration  of this
Agreement,  whether any such  termination be with or without cause or expiration
occurs  with  the  passage  of  time.  Without  limitation,  no  termination  or
expiration of this Agreement  shall relieve Richart of his obligations to DIANON
with respect to the  restrictive  covenant in Section 5 and the  preservation of
confidential  information  under  Section 4. Should  Richart  violate any of the
requirements  of Sections 4 or 5 of this  Agreement,  DIANON may, in addition to
any other remedies  provided to DIANON under this Agreement,  the Asset Purchase
Agreement,   at  law  or  in   equity,   immediately   terminate   any   further
post-termination  payments to Richart  hereunder  that  otherwise  may have been
required.

      10.   WAIVER.  The  failure  of  either  party  at  any  time  to  require
performance  by the other party of any provision  hereof shall not affect in any
way the full right to require such performance at any time thereafter, nor shall
a waiver by either party of a breach of any provision hereof be taken or held to
be a waiver of the provision itself.

      11.   NOTICES.  All notices,  requests,  demands and other  communications
hereunder  shall be in  writing  and shall be deemed to have been duly  given if
delivered by hand, by  nationally  recognized  overnight  delivery  service,  or
mailed by  certified or  registered  mail,  postage  prepaid,  and  addressed as
follows:

            If to Richart:    Ralph M. Richart, M.D.
                              350 Shore Drive
                              Oakdale, New York  11769

            with a copy to:   Brown Raysman  Millstein  Felder & Steiner LLP
                              120 West 45th Street
                              New York, New York 10036
                              Attn: Sarah Hewitt, Esq.




            If to DIANON:     DIANON Systems, Inc.
                              200 Watson Boulevard
                              Stratford, Connecticut  06497
                              Attn: President


      12.   ENTIRE  AGREEMENT.  This Agreement and the Asset Purchase  Agreement
set forth the entire agreement and  understanding of the parties  concerning the
subject  matter  hereof.  This  Agreement  may  be  amended  only  by a  written
instrument signed by both parties, which instrument must make specific reference
to this Agreement and the intention to modify it.

      13.   GOVERNING  LAW. This Agreement shall be governed by and construed in
accordance  with the laws of the  State of New  York  without  reference  to the
conflicts of laws provisions of that state.

      14.   INDEMNIFICATION.  DIANON shall  protect,  defend,  hold harmless and
indemnify  Richart  from  and  against  all  losses,  claims,   actions,  suits,
proceedings,   investigations,  


                                       6
<PAGE>

demands,  liabilities,  judgments,  settlements,  damages,  costs  and  expenses
(including  reasonable  legal  fees and  costs)  which are  asserted  against or
incurred by Richart as a result of, or which arise out of, Richart's performance
of his duties within the scope of his employment with DIANON,  all in accordance
with the May 15, 1997 resolution of the DIANON Board of Directors  pertaining to
indemnification  of  physicians  employed  by it, a copy of  which  is  attached
hereto.

      IN WITNESS WHEREOF, the parties have executed this Agreement as of the day
first above written.


                                          /s/ Ralph M. Richart
                                          --------------------
                                          Ralph M. Richart, M.D.


                                          DIANON SYSTEMS, INC.


                                          /s/ Kevin J. Johnson
                                          --------------------
                                          By:  Kevin J. Johnson
                                          Its:   President & CEO




                                       7





                                                                  EXHIBIT 10.5

                             EMPLOYMENT AGREEMENT



      THIS IS AN EMPLOYMENT AGREEMENT  ("Agreement") made and entered into as of
the 1st day of May,  1999,  by and  between  DIANON  Systems,  Inc.,  a Delaware
corporation ("DIANON"), and Beth Phillips ("Phillips").

                                  RECITALS:

      WHEREAS,  DIANON has acquired substantially all of the assets and business
of Kyto  Meridien  Diagnostics,  L.L.C.,  a New York limited  liability  company
("Kyto Meridien"), pursuant to the terms of an Asset Purchase Agreement dated as
of April 7, 1999, by and among DIANON,  Kyto Meridien,  Kyto Diagnostics,  L.P.,
Meridien  Diagnostics  Labs,  Inc., A. Bruce Shapiro and Ralph M. Richart,  M.D.
(the "Asset Purchase Agreement"); and

      WHEREAS,  DIANON desires to employ Phillips for a period  commencing as of
the Closing Date ("Closing Date") of the Asset Purchase Agreement and ending two
years from that date and Phillips  desires to work for DIANON for such period on
the terms and conditions hereinafter provided; and

      WHEREAS,  Phillips's  position  with Kyto Meridien has given her access to
and familiarity with the confidential  information and business of Kyto Meridien
acquired  by DIANON and her  employment  with DIANON will give her access to and
familiarity with the confidential information and business of DIANON; and

      WHEREAS,  DIANON would be irreparably  harmed if Phillips  should disclose
any of the confidential information which Phillips has acquired and will acquire
or by entering into any activity  competing  with DIANON or the business of Kyto
Meridien acquired by DIANON.

      NOW,  THEREFORE,  in  consideration  of the  mutual  covenants,  terms and
conditions of this Agreement, Phillips and DIANON agree as follows:

      1.    EMPLOYMENT.  DIANON hereby employs  Phillips on a full-time basis to
serve as  Operations  Manager of the New City  facility to perform such services
and such  tasks  and  assignments  that are  reasonably  assigned  to her by the
general  manager  of  the  business  acquired  by  DIANON  consistent  with  her
knowledge,  experience  and position,  which  services  shall  include,  but not
necessarily be limited to, initially aiding in the conversion and implementation
of the Kyto Meridien  business to the  administrative,  financial and laboratory
systems  and  operations  of DIANON  and,  over  time,  assuming  duties for the
management and coordination of non-technical areas of laboratory  operations and
client service.

      During her  employment,  Phillips  shall at all times conduct  herself and
perform her services in a proficient and professional manner, in accordance with
the  applicable  standards  of  care  and  the  highest  standards  of  business
ethics.

      2.    COMPENSATION.  As full  consideration  for the services  rendered by
Phillips  pursuant to this  Agreement,  together  with  Phillips's  undertakings
pertaining to the  


<PAGE>

preservation of confidential information and the restrictive covenant set forth,
respectively,  in Sections 4 and 5 below,  DIANON shall, during the term of this
Agreement, compensate Phillips as follows:

            (a)   DIANON shall pay Phillips an annualized salary of ninety-three
thousand seven hundred ($93,700)  dollars,  payable in twenty-six equal biweekly
(once every two weeks)  increments  of three  thousand six hundred three dollars
and eighty-five cents ($3,603.85);

            (b)   DIANON  shall  reimburse the reasonable  business  expenses of
Phillips in performing  her duties  hereunder in  accordance  with such policies
regarding  employee  expenses  as DIANON  may have in  effect  from time to time
during the term;

            (c)   Phillips shall be eligible for such other employee benefits as
are  generally  provided  by DIANON to its  employees,  subject to the terms and
conditions, including eligibility conditions, of any applicable employee benefit
plan or program;

            (d)   Upon termination of employment,  Phillips may, at her own cost
and in accordance with the requirements of COBRA,  extend her employee insurance
benefits.

      3.    TERM.   Unless sooner terminated in accordance with Section 9 below,
the term of this  Agreement  and  Phillips's  employment  shall  commence on the
Closing Date of the Asset Purchase  Agreement and end on the second  anniversary
thereof.

      4.    CONFIDENTIAL  INFORMATION.  From and after the date hereof, Phillips
will not,  directly  or  indirectly,  use for her own  benefit or  purposes,  or
disclose  to, or use for the  benefit or  purpose of any person or entity  other
than DIANON,  any  confidential  information,  knowledge or data relating to the
business or operations of DIANON or those acquired by DIANON from Kyto Meridien.
Such information,  knowledge or data includes,  but is not limited to, secret or
confidential  matters not published or generally known in the industry,  such as
information regarding pricing, costs, purchasing,  profits, financing,  markets,
sales  or  customer  lists,   future   developments,   audits,   investigations,
enforcement actions, regulatory compliance,  laboratory procedures and marketing
and expansion  plans.  Any and all materials which may be produced or created by
Phillips or others,  or which may come into her  possession in the course of her
employment,  or which  relate  in any  manner  to the  business  or  prospective
business  of  DIANON  are and shall be the  exclusive  property  of  DIANON  and
Phillips shall not have any right, title or interest in any such materials. Upon
termination of her  employment,  Phillips shall not have the right to remove any
such materials  from the offices of DIANON and shall  promptly  return to DIANON
all things of whatever nature that belong to DIANON, including all materials and
records in any form,  format or medium containing or related to the confidential
information  of DIANON,  and she shall  neither make nor retain any part or copy
thereof for her personal use or the use of third parties.

            Notwithstanding  the foregoing,  confidential  information shall not
include any information  that is: (i)  demonstrably  developed  independently by
Phillips;  (ii)  publicly  disclosed by DIANON or otherwise in the public domain
without violation of this Agreement by Phillips; or (iii) rightfully received by
Phillips from a third party,  which, by disclosing to Phillips,  does not breach
any obligation or duty to DIANON.  Notwithstanding  this Section 4, Phillips may
make such disclosures of confidential information as are duly compelled by court
order or as required by law.


                                       2
<PAGE>

      5.    RESTRICTIVE  COVENANT.  In  consideration  of this Agreement,  for a
period of two years from and after the Closing  Date and for any renewal  period
or extension of the term hereof, and  notwithstanding any earlier termination of
this Agreement, except upon the express written consent of DIANON (which consent
may be  unreasonably  withheld),  Phillips  shall not, for her own  account,  on
behalf of, or jointly  with,  any other  person,  directly or  indirectly,  own,
manage, operate, join, control, finance, invest in, perform services for, advise
(or advise others with respect to), or otherwise participate in, or be connected
with,  or  become  or act as a  partner,  manager,  member,  director,  officer,
employee,  consultant,  representative  or agent  of any  business  (other  than
DIANON), individual,  partnership, firm, proprietorship,  professional practice,
corporation,  limited  liability  company or other entity that provides clinical
laboratory or anatomic or surgical  pathology  services within a one hundred and
fifty mile radius of New York City; provided however, that Phillips may purchase
or own,  solely as an inactive  investor,  the securities of any entity that are
publicly traded on a national  securities  exchange where  Phillips's  aggregate
holdings of such  securities do not exceed two percent of the voting power or of
any class of stock of such entity.

            In  addition to the foregoing,  during the same two-year  period and
for any renewal  period or extension of the term hereof,  Phillips shall not, on
her own  behalf,  or on behalf of any other  person or entity:  (i)  solicit the
customers,  suppliers  or  employees of DIANON or any  affiliated  entity;  (ii)
solicit or seek to hire any  employee  of DIANON or any  affiliated  entity;  or
(iii) attempt in any manner,  directly or  indirectly,  to influence,  induce or
encourage any such employee to leave the  employment of DIANON or any affiliated
entity.  Phillips shall not take any action intended, or which may reasonably be
expected,  directly or  indirectly,  to impair the goodwill,  reputation or good
name of DIANON or Kyto Meridien, or otherwise to be detrimental to the interests
of DIANON,  including any action intended,  or which may reasonably be expected,
directly or indirectly to benefit a competitor of DIANON.

      6.    SCOPE OF  RESTRICTIONS.  Phillips agrees that the  restrictions  set
forth in Section 5 are  reasonable.  If,  however,  a court  determines that any
provision of Section 5 is unreasonable,  either in geographic  scope,  length of
time or  otherwise,  then  Section 5 shall be  interpreted  and  enforced to the
maximum extent permitted by law and Phillips consents and agrees that such scope
may be judicially modified accordingly in any proceeding brought to enforce such
restriction.

      7.    INJUNCTIVE RELIEF. Phillips acknowledges that irreparable harm would
be suffered by DIANON in the event that any of the provisions of Sections 4 or 5
were not performed fully n accordance with the terms specified  therein and that
monetary  damages are an  inadequate  remedy for breach  thereof  because of the
difficulty of  ascertaining  and  quantifying  the amount of damage that will be
suffered  by DIANON in the event  that such  undertakings  and  provisions  were
breached or violated. Accordingly, Phillips agrees that DIANON shall be entitled
to an  injunction or  injunctions  to restrain,  enjoin and prevent  breaches or
threatened  breaches of the  covenants,  undertakings  and  provisions  of those
sections and to enforce  specifically the provisions therein in any court of the
United  States  or any  state  having  jurisdiction  over the  matter,  it being
understood  that any such remedies  shall be in addition to, and not in lieu of,
any other  rights and  remedies  available  at law or in equity and shall not be
deemed  exclusive of any common law or other rights of DIANON in connection with
the matters covered hereby.


                                       3
<PAGE>

      8.    INTELLECTUAL  PROPERTY RIGHTS. Phillips agrees to assign, and hereby
does  assign to  DIANON  all of her  right,  title  and  interest  in and to all
inventions, improvements, discoveries and technical developments, whether or not
patentable,  which she solely or jointly with others,  may conceive or reduce to
practice  during the term of her employment,  which are related,  in whole or in
part, directly or indirectly, to the business of, or services or products of the
type, provided by DIANON, or which may reasonably be provided or used by DIANON,
or which are otherwise developed, in whole or in part, at DIANON's expense.

      Phillips shall disclose  promptly to DIANON,  all such ideas,  discoveries
and  improvements  conceived by her alone or in collaboration  with others,  and
shall cooperate fully with DIANON both during and after employment, with respect
to the procurement of patents for the  establishment and maintenance of DIANON's
rights  and  interests  in  said   inventions,   improvements,   discoveries  or
developments,  and shall  sign all  papers  which  DIANON  may  reasonably  deem
necessary or desirable for the purpose of vesting it with such rights.

      9.   TERMINATION.      (a) Phillips's  employment  under this Agreement
shall terminate on the occurrence of any of the following events:

            (i)   Upon the death of Phillips;

            (ii)  Upon  the sending of written notice from DIANON describing the
activities  constituting an act of default falling within any one or more of the
following categories:

                  (A) Phillips's breach of any material promise or agreement set
                  forth  herein or failure to perform  (other  than for  reasons
                  beyond her control) substantially all of the duties reasonably
                  required by Section 1; or

                  (B)  Phillips's  commission  of an act of gross  negligence or
                  willful  misconduct,  or acts showing a pattern of negligence,
                  in the performance of her duties or obligations hereunder;

Provided that no such termination  under this subsection 9(b) shall be effective
unless  Phillips has first been afforded an  opportunity  to correct the alleged
default,  but such default continues,  recurs or can not otherwise be corrected,
in the good faith judgment of DIANON,  within thirty days after delivery of such
written notice of default to Phillips;

            (iii) Upon  the  occurrence of an event or the  commission of an act
under  which  Phillips  is or may become  subject  to  mandatory  or  permissive
exclusion  from  Medicare and State health care  programs,  including  those set
forth  in  sections  1128,  1156  and 1892 of the  Social  security  Act and any
regulations promulgated thereunder; and

            (iv)  Upon  the passage of thirty  (30)days  after written notice of
termination without cause from DIANON to Phillips.

      (b)   In  the  event  of a  termination  of  this  Agreement  pursuant  to
subsection  9(a)(iv)  above,  DIANON  shall  continue  to pay  the  compensation
required by subsection  2(a) above until the second  anniversary  of the Closing
Date of the Asset Purchase Agreement.


                                       4
<PAGE>

      (c)   Section  4, 5, 6, 7, 11 and 13 of this Agreement  shall survive,  in
accordance  with their terms,  any  termination or expiration of this Agreement,
whether any such termination be with or without cause or expiration  occurs with
the passage of time.  Without  limitation,  no termination or expiration of this
Agreement  shall relieve  Phillips of her  obligations to DIANON with respect to
the  restrictive  covenant  in Section 5 and the  preservation  of  confidential
information  under Section 4. Should Phillips violate any of the requirements of
Sections 4 or 5 of this Agreement, DIANON may, in addition to any other remedies
provided  to DIANON  under  this  Agreement,  at law or in  equity,  immediately
terminate  any further  post-termination  payments to  Phillips  hereunder  that
otherwise may have been required.

      10.   WAIVER.  The  failure  of  either  party  at  any  time  to  require
performance  by the other party of any provision  hereof shall not affect in any
way the full right to require such performance at any time thereafter, nor shall
a waiver by either party of a breach of any provision hereof be taken or held to
be a waiver of the provision itself.

      11.   NOTICES.  All notices,  requests,  demands and other  communications
hereunder  shall be in  writing  and shall be deemed to have been duly  given if
delivered by hand, by  nationally  recognized  overnight  delivery  service,  or
mailed by  certified or  registered  mail,  postage  prepaid,  and  addressed as
follows:

            If to Phillips:   Beth Phillips
                              3 South Grant Ave.
                              Congers, New York 10920

            If to DIANON:     DIANON Systems, Inc.
                              200 Watson Boulevard
                              Stratford, Connecticut  06497
                              Attn: President

      12.   ENTIRE  AGREEMENT.  This Agreement and the Asset Purchase  Agreement
set forth the entire agreement and  understanding of the parties  concerning the
subject  matter  hereof.  This  Agreement  may  be  amended  only  by a  written
instrument signed by both parties, which instrument must make specific reference
to this Agreement and the intention to modify it.

      13.   GOVERNING  LAW. This Agreement shall be governed by and construed in
accordance  with the laws of the  State of New  York  without  reference  to the
conflicts of laws provisions of that state.


                                       5
<PAGE>


      IN WITNESS WHEREOF, the parties have executed this Agreement as of the day
first above written.



                                          /s/ Beth Phillips
                                          -----------------
                                          Beth Phillips



                                          DIANON SYSTEMS, INC.


                                          /s/ Kevin C. Johnson
                                          --------------------
                                          By:  Kevin C. Johnson
                                          Its:   President & CEO





                                       6





                                                                  EXHIBIT 10.6

                             EMPLOYMENT AGREEMENT


      THIS IS AN EMPLOYMENT AGREEMENT  ("Agreement") made and entered into as of
the 1st day of May,  1999,  by and  between  DIANON  Systems,  Inc.,  a Delaware
corporation ("DIANON"), and Dana Shapiro ("Employee").

                                  RECITALS:

      WHEREAS,  DIANON has acquired substantially all of the assets and business
of Kyto  Meridien  Diagnostics,  L.L.C.,  a New York limited  liability  company
("Kyto Meridien"), pursuant to the terms of an Asset Purchase Agreement dated as
of April 7, 1999, by and among DIANON,  Kyto Meridien,  Kyto Diagnostics,  L.P.,
Meridien  Diagnostics  Labs, Inc., Ralph M. Richart,  M.D., and A. Bruce Shapiro
(the "Asset Purchase Agreement"); and

      WHEREAS,  DIANON desires to employ Employee for a period  commencing as of
the Closing Date ("Closing Date") of the Asset Purchase Agreement and ending two
years from that date and Employee  desires to work for DIANON for such period on
the terms and conditions hereinafter provided; and

      WHEREAS,  Employee's  position  with Kyto Meridien has given her access to
and familiarity with the confidential  information and business of Kyto Meridien
acquired  by DIANON and her  employment  with DIANON will give her access to and
familiarity with the confidential information and business of DIANON; and

      WHEREAS,  DIANON would be irreparably  harmed if Employee  should disclose
any of the confidential information which Employee has acquired and will acquire
or by entering into any activity  competing  with DIANON or the business of Kyto
Meridien acquired by DIANON.

      NOW,  THEREFORE,  in  consideration  of the  mutual  covenants,  terms and
conditions of this Agreement, Employee and DIANON agree as follows:

      1.    EMPLOYMENT.  DIANON hereby employs Employee to serve as the Cytology
Supervisor  at the  Woodbury  facility.  Employee's  duties shall  include:  (i)
part-time  (as defined  below)  service as  statutory  Cytology  Supervisor  and
provision  of overall  supervision  and  direction of  cytotechnologists  at the
laboratory  facility acquired by DIANON from Kyto Meridien  currently located at
40  Crossways  Park  Drive  in  Woodbury,  New  York;  (ii)  performance  of all
requirements of a cytology  supervisor  specified under CLIA, New York State law
and other federal,  state and local laws, rules and regulations;  (iii) assuring
that the laboratory  facility for which she serves as cytology  supervisor is in
compliance  with applicable  laws,  rules and  regulations;  and (iv) such other
tasks  and  assignments  commensurate  with her  position  that  are  reasonably
assigned  to her by the  senior  management  of  DIANON.  Employee  shall have a
reporting  relationship  with the general manager of Kyto Meridien or such other
person or persons as are designated by the President of DIANON.

      For  purposes of this  Agreement,  the term  "part-time"  means an on-site
schedule  from 9 a.m. to 2 p.m.  (hereinafter  referred to as a "work day"),  on
normal  business  days, two hundred and sixty (260) days per year less such four
weeks  (twenty  business  days)  vacation,  holiday and 


<PAGE>

other paid time off days  (hereinafter  referred  to as "paid time off days") to
which  Employee is entitled.  Employee  may work fewer work days than  otherwise
would be required by the preceding  sentence,  provided that:  (a)  compensation
under  Section  2(a) below shall be paid only for actual work days  performed by
Employee or paid time off days  recognized  by DIANON;  and (b)  Employee  shall
provide  no less than two (2)  calendar  weeks  advance  notice  to the  general
manager of Kyto Meridien prior to taking additional days off.

      During her  employment  Employee  shall at all times  conduct  herself and
perform her professional  services in a proficient and professional  manner,  in
accordance  with the applicable  standards of care and the highest  standards of
ethics of the medical profession.

      2.   COMPENSATION.  As full  consideration  for the services  rendered by
Employee  pursuant to this  Agreement,  together  with  Employee's  undertakings
pertaining to the  preservation of confidential  information and the restrictive
covenant  set forth,  respectively,  in  Sections 4 and 5 below,  DIANON  shall,
during the term of this Agreement, compensate Employee as follows:

            (a)   DIANON shall pay Employee on a biweekly (once every two weeks)
basis a per diem equal to two hundred  eighty-eight  dollars and forty-six cents
($288.46)  for each work day  performed  by Employee  and each paid time off day
during the  preceding  two week pay period,  provided that the total of all such
payments shall not exceed  seventy-five  thousand  ($75,000)  dollars in any one
year;

            (b)   DIANON  shall  reimburse the reasonable  business  expenses of
Employee in performing  her duties  hereunder in  accordance  with such policies
regarding  employee  expenses  as DIANON  may have in  effect  from time to time
during the term;

            (c)   Employee shall be eligible for group health insurance benefits
as are generally  provided by DIANON to its  employees  subject to the terms and
conditions, including eligibility conditions other than status as a full-time or
part-time  employee,  that are  applicable  to such health  insurance  programs.
Employee  shall be eligible for such other  employee  benefits as are  generally
provided  by  DIANON to its  employees  subject  to the  terms  and  conditions,
including  eligibility  conditions,  of any applicable  employee benefit plan or
program;  provided that, during the period of employee conversion, as determined
by DIANON  consistent  with the  requirements  of the Asset Purchase  Agreement,
Employee  shall be entitled to such Kyto Meridien  benefits that are required by
Section 7(c) of the Asset Purchase Agreement to be extended to all Kyto Meridien
employees hired by DIANON;

            (d)   Upon termination of employment,  Employee may, at her own cost
and in accordance with the requirements of COBRA,  extend her employee insurance
benefits.

      3.    TERM.   Unless sooner terminated in accordance with Section 9 below,
the term of this  Agreement  and  Employee's  employment  shall  commence on the
Closing Date of the Asset Purchase  Agreement and end on the second  anniversary
thereof.

      4.    CONFIDENTIAL  INFORMATION.  From and after the date hereof, Employee
will not,  directly  or  indirectly,  use for her own  benefit or  purposes,  or
disclose  to, or use for the  benefit or  purpose of any person or entity  other
than DIANON,  any  confidential  information,  knowledge or data relating to the
business or operations of DIANON or those acquired by 


                                       2
<PAGE>

DIANON from Kyto Meridien. Such information,  knowledge or data includes, but is
not limited to, secret or confidential  matters not published or generally known
in the industry,  such as  information  regarding  pricing,  costs,  purchasing,
profits,  financing,  markets,  sales or customer  lists,  future  developments,
audits, investigations,  enforcement actions, regulatory compliance,  laboratory
procedures and marketing and expansion plans. Any and all materials which may be
produced or created by Employee or others, or which may come into her possession
in the course of her  employment,  or which relate in any manner to the business
or  prospective  business of DIANON are and shall be the  exclusive  property of
DIANON and  Employee  shall not have any right,  title or  interest  in any such
materials. Upon termination of her employment, Employee shall not have the right
to remove any such  materials  from the  offices  of DIANON  and shall  promptly
return to DIANON all things of whatever nature that belong to DIANON,  including
all materials and records in any form, format or medium containing or related to
the  confidential  information of DIANON,  and she shall neither make nor retain
any part or copy thereof for her personal use or the use of third parties.

            Notwithstanding  the foregoing,  confidential  information shall not
include any information  that is: (i)  demonstrably  developed  independently by
Employee;  (ii)  publicly  disclosed by DIANON or otherwise in the public domain
without violation of this Agreement by Employee; or (iii) rightfully received by
Employee from a third party,  which, by disclosing to Employee,  does not breach
any obligation or duty to DIANON.  Notwithstanding  this Section 4, Employee may
make such disclosures of confidential information as are duly compelled by court
order or as required by law.

      5.    RESTRICTIVE  COVENANT.  In  consideration  of this Agreement and the
purchase of the assets and business of Kyto Meridien by DIANON,  for a period of
three  years  from and  after the  Closing  Date and for any  renewal  period or
extension of the term hereof, and  notwithstanding the expiration or any earlier
termination of this Agreement, except with the express written consent of DIANON
(which consent may be  unreasonably  withheld),  Employee shall not, for her own
account,  on  behalf  of,  or  jointly  with,  any  other  person,  directly  or
indirectly,  own, manage,  operate, join, control,  finance,  invest in, perform
services  for,   advise  (or  advise  others  with  respect  to),  or  otherwise
participate  in, or be connected  with, or become or act as a partner,  manager,
member, director, officer, employee, consultant,  representative or agent of any
business (other than DIANON),  individual,  partnership,  firm,  proprietorship,
professional  practice,  corporation,  limited liability company or other entity
that provides  clinical  laboratory or anatomic or surgical  pathology  services
within a one hundred  and fifty mile radius of New York City (the  "Territory");
provided  however,  that  Employee  may  purchase or own,  solely as an inactive
investor,  the  securities of any entity that are publicly  traded on a national
securities  exchange where Employee's  aggregate  holdings of such securities do
not  exceed two  percent  of the  voting  power or of any class of stock of such
entity.

            In addition to the foregoing,  during the same three-year period and
for any renewal  period or extension of the term hereof,  Employee shall not, on
her own  behalf,  or on behalf of any other  person or entity:  (i)  solicit the
customers,  suppliers  or  employees of DIANON or any  affiliated  entity;  (ii)
solicit or seek to hire any  employee  of DIANON or any  affiliated  entity;  or
(iii) attempt in any manner,  directly or  indirectly,  to influence,  induce or
encourage any such employee to leave the  employment of DIANON or any affiliated
entity.  Employee  shall not take any action  intended,  or which may reasonably
expected,  directly or  indirectly,  to impair the goodwill,  reputation or good
name of DIANON or Kyto Meridien, or 


                                       3
<PAGE>

otherwise to be  detrimental  to the  interests of DIANON,  including any action
intended,  or which may  reasonably  be  expected,  directly or  indirectly,  to
benefit a competitor of DIANON.

            Notwithstanding the foregoing,  Employee may, upon the expiration or
termination  of this  Agreement  other than for cause,  be  employed  within the
Territory as a cytotechnologist or cytology supervisor in a hospital laboratory,
for so long as such hospital  laboratory  does not conduct  outreach  activities
having annual sales in excess of two million ($2,000,000)  dollars, and provided
further that Employee  otherwise  abides by the requirements of this restrictive
covenant and the other  provisions of this Agreement that survive  expiration or
termination.

      6.    SCOPE OF  RESTRICTIONS.  Employee agrees that the  restrictions  set
forth in Section 5 are  reasonable.  If,  however,  a court  determines that any
provision of Section 5 is unreasonable,  either in geographic  scope,  length of
time or  otherwise,  then  Section 5 shall be  interpreted  and  enforced to the
maximum extent permitted by law and Employee consents and agrees that such scope
may be judicially modified accordingly in any proceeding brought to enforce such
restriction.

      7.    INJUNCTIVE RELIEF. Employee acknowledges that irreparable harm would
be suffered by DIANON in the event that any of the provisions of Sections 4 or 5
were not performed fully in accordance with the terms specified therein and that
monetary  damages are an  inadequate  remedy for breach  thereof  because of the
difficulty of  ascertaining  and  quantifying  the amount of damage that will be
suffered  by DIANON in the event  that such  undertakings  and  provisions  were
breached or violated. Accordingly, Employee agrees that DIANON shall be entitled
to an  injunction or  injunctions  to restrain,  enjoin and prevent  breaches or
threatened  breaches of the  covenants,  undertakings  and  provisions  of those
sections and to enforce  specifically the provisions therein in any court of the
United  States  or any  state  having  jurisdiction  over the  matter,  it being
understood  that any such remedies  shall be in addition to, and not in lieu of,
any other  rights and  remedies  available  at law or in equity and shall not be
deemed  exclusive of any common law or other rights of DIANON in connection with
the matters covered hereby.

      8.    INTELLECTUAL  PROPERTY RIGHTS. Employee agrees to assign, and hereby
does  assign to  DIANON  all of her  right,  title  and  interest  in and to all
inventions, improvements, discoveries and technical developments, whether or not
patentable,  which she solely or jointly with others,  may conceive or reduce to
practice  during the term of her employment,  which are related,  in whole or in
part, directly or indirectly, to the business of, or services or products of the
type, provided by DIANON, or which may reasonably be provided or used by DIANON,
or which are otherwise developed, in whole or in part, at DIANON's expense.

      Employee shall disclose promptly to DIANON's Chief Executive Officer,  all
such  ideas,   discoveries  and  improvements  conceived  by  her  alone  or  in
collaboration with others, and shall cooperate fully with DIANON both during and
after   employment,   with  respect  to  the  procurement  of  patents  for  the
establishment   and  maintenance  of  DIANON's  rights  and  interests  in  said
inventions, improvements, discoveries or developments, and shall sign all papers
which DIANON may  reasonably  deem  necessary  or  desirable  for the purpose of
vesting it with such rights.


                                       4
<PAGE>

      9.    TERMINATION.      (a) Employee's  employment  under this Agreement
shall terminate on the occurrence of any of the following events:

            (i)   Upon  the  disqualification  of  Employee,  or her  failure to
maintain  all  necessary  licenses  and  certifications,  to serve as a cytology
supervisor in the State of New York or under CLIA;

            (ii)  Upon the death of Employee;

            (iii) Upon  the passage of thirty (30) days after written  notice of
termination without cause from DIANON to Employee;

            (iv)  Upon  the sending of written notice from DIANON describing the
activities  constituting an act of default falling within any one or more of the
following categories:

                  (i)   Employee's  breach of any material  promise or agreement
                        set forth herein, including,  without limitation,  those
                        set  forth in  Sections  4 and 5 above,  or  failure  to
                        perform  substantially  all  of  the  duties  reasonably
                        required by Section 1; or

                  (ii)  Employee's  commission of an act of gross  negligence or
                        willful  misconduct in the  performance of her duties or
                        obligations  hereunder,  or an act of  negligence in the
                        performance of a medical function;

Provided  that no such  termination  under  this  subsection  9(a)(iv)  shall be
effective  unless Employee has first been afforded an opportunity to correct the
alleged  default,  but such default  continues,  recurs or can not  otherwise be
corrected,  in the good faith  judgment  of  DIANON,  within  thirty  days after
delivery of such written notice of default to Employee; and

            (v)   Upon  the  occurrence of an event or the  commission of an act
under  which  Employee  is or may become  subject  to  mandatory  or  permissive
exclusion  from  Medicare and State health care  programs,  including  those set
forth  in  sections  1128,  1156  and 1892 of the  Social  security  Act and any
regulations promulgated thereunder.

      (b)   In  the  event  of a  termination  of  this  Agreement  pursuant  to
subsections  9(a)(ii)  or  9(a)(iii)  above,  DIANON  shall  continue to pay the
maximum compensation required by Section 2(a) above until the second anniversary
of the Closing Date of the Asset Purchase Agreement.

      (c)   Sections  4, 5, 6, 7, 11 and 13 of this Agreement shall survive,  in
accordance  with their terms,  any  termination or expiration of this Agreement,
whether any such termination be with or without cause or expiration  occurs with
the passage of time.  No  termination  or  expiration  of this  Agreement  shall
relieve  Employee of her  obligations to DIANON with respect to the  restrictive
covenant in Section 5 and the  preservation  of confidential  information  under
Section 4. Should Employee violate any of the requirements of Sections 4 or 5 of
this Agreement, DIANON may, in addition to any other remedies provided to DIANON
under  this  Agreement,  the  Asset  Purchase  Agreement,  at law or in  equity,
immediately  terminate  any  further   post-termination   payments  to  Employee
hereunder that otherwise may have been required.


                                       5
<PAGE>

      10.   WAIVER.  The  failure  of  either  party  at  any  time  to  require
performance  by the other party of any provision  hereof shall not affect in any
way the full right to require such performance at any time thereafter, nor shall
a waiver by either party of a breach of any provision hereof be taken or held to
be a waiver of the provision itself.

      11.   NOTICES.  All notices,  requests,  demands and other  communications
hereunder  shall be in  writing  and shall be deemed to have been duly  given if
delivered by hand, by  nationally  recognized  overnight  delivery  service,  or
mailed by  certified or  registered  mail,  postage  prepaid,  and  addressed as
follows:

            If to Employee:
                              Dana Shapiro
                              40 Juneau Boulevard
                              Woodbury, New York 11797
                  

            If to DIANON:     DIANON Systems, Inc.
                              200 Watson Boulevard
                              Stratford, Connecticut  06497
                              Attn: President

      12.   ENTIRE  AGREEMENT.  This Agreement and the Asset Purchase  Agreement
set forth the entire agreement and  understanding of the parties  concerning the
subject  matter  hereof.  This  Agreement  may  be  amended  only  by a  written
instrument signed by both parties, which instrument must make specific reference
to this Agreement and the intention to modify it.


      13.  GOVERNING  LAW. This Agreement shall be governed by and construed in
accordance  with the laws of the  State of New  York  without  reference  to the
conflicts of laws provisions of that state.


                                       6
<PAGE>



      IN WITNESS WHEREOF, the parties have executed this Agreement as of the day
first above written.



                                          /s/ Dana Shapiro
                                          ----------------
                                          Dana Shapiro



                                          DIANON SYSTEMS, INC.


                                          /s/ Kevin C. Johnson
                                          --------------------
                                          By:  Kevin C. Johnson
                                          Its:   President & CEO




                                       7





                                                                      EXHIBIT 23



                  CONSENT OF INDEPENDENT PUBLIC ACCOUNTANTS


As independent public accountants, we hereby consent to the incorporation of our
report,  dated March 19, 1999,  on the  financial  statements  of Kyto  Meridien
Diagnostics,  L.L.C.  as of and for the year ended December 31, 1998 included in
this  Form 8-K of DIANON  Systems,  Inc.  It  should  be noted  that we have not
audited any financial statements of the company subsequent to
 December 31, 1998 or performed any audit  procedures  subsequent to the date of
our report.



                                                           ARTHUR ANDERSEN LLP




Stamford, Connecticut
May 4, 1999






EXHIBIT 99.1

FOR IMMEDIATE RELEASE

Contacts:
DIANON Systems, Inc.                Noonan/Russo Communications, Inc.
Kevin C. Johnson                    (212) 696-4455
President and CEO                   Heather Regan (media), ext. 241
(203) 381-4905                      Belinda Brouder (investors), ext. 224
                                    [email protected]
David R. Schreiber
Chief Financial Officer
(203) 381-4055

              DIANON SYSTEMS, INC. SIGNS DEFINITIVE AGREEMENT TO
               ACQUIRE ASSETS OF KYTO MERIDIEN DIAGNOSTICS, LLC

Stratford,  CT,  April 8, 1999 - DIANON  Systems,  Inc.  (NASDAQ:  DIAN),  today
announced that it has successfully  completed its due diligence and has signed a
definitive agreement to acquire substantially all of the assets of Kyto Meridien
diagnostics, LLC, an outpatient Ob/Gyn laboratory with locations in Woodbury and
New City,  New York.  The  acquisition  is scheduled to become  effective May 1,
1999.

"The addition of Kyto Meridien to our company will provide substantial  economic
as well as strategic  benefits,"  commented  David  Schreiber,  chief  financial
officer  of DIANON  Systems.  "Kyto's  current  profitability  coupled  with the
projected  synergies  between  our  organizations  should  make the  acquisition
accretive to earnings in the second half of 1999, in addition to increasing  our
1999 sales by approximately $8 million."

As previously  announced,  Kyto Meridien  enjoys an  outstanding  reputation for
clinical  excellence  and  is  recognized   nationally  as  a  premier  cytology
laboratory in the Northeast. Ralph Richart, MD, a world leader in cytology and a
tenured professor at Columbia  University's  College of Physicians and Surgeons,
is the medical  director of Kyto  Meridien and will remain in this capacity with
DIANON.  DIANON  believes  that  Kyto  Meridien's  Ob/Gyn  focus  represents  an
excellent  fit with  DIANON's  full  service  anatomic  pathology  offering  and
enhances DIANON's strategic opportunities on many levels.

DIANON Systems, Inc. provides a full line of anatomic pathology testing services
and a number of genetic and  clinical  chemistry  testing  services to patients,
physicians, and managed care organizations throughout the United States.

The  forward-looking  statements in this news release  relating to  management's
expectations  and beliefs are based on  preliminary  information  and management
assumptions.  Such  forward-looking  statements  are  subject to a wide range of
risks and uncertainties that could cause results to differ in material respects,
including those relating to reimbursement rates and coverage, state and national
regulatory compliance, the Company's maintenance of above-average quality of its
services and products and competitive  pressures.  Further information regarding
factors that could affect the Company's results is included in the Company's SEC
filings, including this year's Form 10-K.






                                                                  EXHIBIT 99.2


                  KYTO MERIDIEN DIAGNOSTICS, L.L.C.

                  FINANCIAL STATEMENTS
                  TOGETHER WITH AUDITORS' REPORT
                  AS OF DECEMBER 31, 1998





<PAGE>





                   REPORT OF INDEPENDENT PUBLIC ACCOUNTANTS



To the Members of
Kyto Meridien Diagnostics, L.L.C.:


We have audited the  accompanying  balance sheet of Kyto  Meridien  Diagnostics,
L.L.C. as of December 31, 1998, and the related  statements of income,  members'
equity and cash flows for the year then ended.  These  financial  statements are
the responsibility of the Company's management. Our responsibility is to express
an opinion on these financial statements based on our audit.

We conducted our audit in accordance with generally accepted auditing standards.
Those standards  require that we plan and perform the audit to obtain reasonable
assurance   about  whether  the  financial   statements  are  free  of  material
misstatement.  An audit includes examining, on a test basis, evidence supporting
the amounts and disclosures in the financial statements.  An audit also includes
assessing the  accounting  principles  used and  significant  estimates  made by
management,  as well as evaluating the overall financial statement presentation.
We believe our audit provides a reasonable basis for our opinion.

In our opinion,  the financial  statements  referred to above present fairly, in
all material  respects,  the financial  position of Kyto  Meridien  Diagnostics,
L.L.C.  as of December 31, 1998,  and the results of its operations and its cash
flows for the year then ended in conformity with generally  accepted  accounting
principles.

Our audit was  conducted  for the  purpose  of  forming  an opinion on the basic
financial statements taken as a whole. The supplementary  schedules presented on
pages 9 and 10 are presented  for purposes of additional  analysis and are not a
required  part of the basic  financial  statements.  Such  information  has been
subjected to the auditing procedures applied in the audit of the basic financial
statements  and, in our opinion,  is fairly  stated in all material  respects in
relation to the basic financial statements taken as a whole.


                               Arthur Andersen LLP


Stamford, Connecticut
March 19, 1999




<PAGE>






                      KYTO MERIDIEN DIAGNOSTICS, L.L.C.


                                BALANCE SHEET

                              DECEMBER 31, 1998




ASSETS

CURRENT ASSETS:
  Cash and cash equivalents                                           
                                                                      $932,175
  Accounts receivable, net of allowance for doubtful
    accounts of $1,120,086                                           3,331,435
  Accrued interest                                                       3,228
  Prepaid expenses and other current assets                            121,820
                                                                     ---------
           Total current assets                                      4,388,658


PROPERTY AND EQUIPMENT, net                                            330,863

OTHER ASSETS:
  Organization costs                                                    33,397
                                                                    ----------
                                                                    $4,752,918
                                                                    ==========

LIABILITIES AND MEMBERS' EQUITY

CURRENT LIABILITIES:
  Accounts payable - trade                                            
                                                                     $ 471,640
  Accrued expenses                                                     646,524
                                                                    ----------

           Total current liabilities                                 1,118,164

MEMBERS' EQUITY                                                      3,634,754
                                                                    ----------

                                                                    $4,752,918
                                                                    ==========



      The accompanying notes are an integral part of this balance sheet.





<PAGE>





                      KYTO MERIDIEN DIAGNOSTICS, L.L.C.


                             STATEMENT OF INCOME

                     FOR THE YEAR ENDED DECEMBER 31, 1998




NET REVENUES                                                     $14,631,433

COST OF OPERATIONS
                                                                   7,035,159
                                                                   ---------
           Gross profit                                            7,596,274
                                                                   ---------
OPERATING EXPENSES:
  General and administrative expenses                              5,063,585
  Selling expenses                                                   404,284
                                                                   ---------
                                                                   5,467,869
                                                                   ---------
           Income before members' salaries                         2,128,405

MEMBERS' SALARIES                                                    850,419
                                                                   ---------
           Income from operations                                  1,277,986

OTHER INCOME (EXPENSE):
  Interest income                                                     15,631
  Loss on disposal of fixed assets                                 
                                                                     (10,301)
                                                                     ------- 

           Net income                                             $ 1,283,316
                                                                  ===========



   The accompanying notes are an integral part of this financial statement.




                                       2
<PAGE>





                      KYTO MERIDIEN DIAGNOSTICS, L.L.C.


                         STATEMENT OF MEMBERS' EQUITY

                     FOR THE YEAR ENDED DECEMBER 31, 1998





MEMBERS' EQUITY, January 1, 1998                                 $2,599,475

ADD:  Net income                                                  
                                                                   1,283,316
                                                                   ---------
                                                                   3,882,791

LESS:  Members' withdrawals                                          248,037
                                                                  ----------
MEMBERS' EQUITY, December 31, 1998                                $3,634,754
                                                                  ----------




   The accompanying notes are an integral part of this financial statement.




                                       3
<PAGE>





                      KYTO MERIDIEN DIAGNOSTICS, L.L.C.


                           STATEMENT OF CASH FLOWS

                     FOR THE YEAR ENDED DECEMBER 31, 1998




CASH FLOWS FROM OPERATING ACTIVITIES:
  Net income                                                      $ 1,283,316
  Adjustments  to  reconcile  net  income  to  net  cash
  provided by operating activities:
      Depreciation                                                    128,910
      Amortization                                                     11,132
      Loss on disposal of property and equipment                       10,301
      Provision for bad debts                                       1,296,815
    Changes in operating assets and liabilities:
      Increase in accounts receivable                              (1,818,948)
      Increase in accrued interest                                     (3,228)
      Decrease in prepaid expenses                                     15,736
      Increase in accounts payable                                    112,132
      Decrease in accrued expenses                                     (3,373)
                                                                    --------- 
           Net cash provided by operating activities                1,032,793
                                                                    ---------

CASH FLOWS FROM INVESTING ACTIVITIES:
  Purchase of property and equipment                                  (95,901)
                                                                    ----------

CASH FLOWS FROM FINANCING ACTIVITIES:
  Members' withdrawals                                               (248,037)
  Remaining payments on capital leases                                (56,481)
                                                                    ---------
           Net cash used in financing activities                     (304,518)
                                                                    ---------
           Increase in cash and cash equivalents                      632,374

CASH AND CASH EQUIVALENTS, December 31, 1997                          299,801

CASH AND CASH EQUIVALENTS, December 31, 1998                        $ 932,175
                                                                    ---------



   The accompanying notes are an integral part of this financial statement.




                                       4
<PAGE>





                      KYTO MERIDIEN DIAGNOSTICS, L.L.C.


                        NOTES TO FINANCIAL STATEMENTS

                         YEAR ENDED DECEMBER 31, 1998



1.   Organization and Summary of Significant Accounting Policies:

     The following summary of significant  accounting  policies of Kyto Meridien
     Diagnostics, L.L.C. (the "Company") is presented to assist in understanding
     the Company's financial statements.

       Business activity-

       The Company  operates two pathology  laboratories.  The  laboratories are
       located  in  Rockland  County and Nassau  County in New York  State.  The
       Company  primarily  performs  cytology and histology  testing relative to
       ob-gyn cancer screening.  The Company also performs additional testing in
       microbiology,  hematology and other areas.  The Company  performs testing
       for doctors throughout the United States.

       Business formation-

       The Company is a New York State  limited  liability  company  ("L.L.C."),
       which was established on January 1, 1997, when Kyto Diagnostics, L.P. and
       Meridien   Diagnostic  Labs,  Inc.  (the  "Members")   contributed  their
       operations and equipment into the new entity.  As an L.L.C.,  the Company
       has a finite  life and will  cease to exist on  December  31,  2046.  The
       Members of the Company are not personally  responsible  for the Company's
       debts, except to the extent of their investment.

       Use of estimates-

       The  preparation  of financial  statements in conformity  with  generally
       accepted accounting  principles requires management to make estimates and
       assumptions  that affect the reported  amounts of assets and  liabilities
       and  disclosure of contingent  assets and  liabilities at the date of the
       financial  statements  and the  reported  amounts of revenue and expenses
       during the  reporting  period.  Actual  results  could  differ from those
       estimates.

       Cash and cash equivalents-

       For purposes of the  statement of cash flows,  the Company  considers all
       short-term  investments purchased with a maturity of three months or less
       to be cash equivalents.


                                       5
<PAGE>





       Property and equipment-

       Property and equipment  are stated at cost.  They are  depreciated  using
       straight-line and accelerated  methods over the estimated useful lives of
       5-7  years.  Depreciation  for the  year  ended  December  31,  1998  was
       $128,910.

       Expenditures  for major renewals and  betterments  that extend the useful
       lives  of  property  and  equipment  are  capitalized.  Expenditures  for
       maintenance and repairs are charged to expense as incurred.

       Organization costs-

       The  organization  costs are recorded as an asset and are being amortized
       over five years on a straight-line basis.

       Net revenues-

       Provisions for estimated  third-party payor  settlements  included in net
       laboratory  fees are  provided  in the period the  related  services  are
       rendered. Differences between the estimated amounts accrued and the final
       settlements are reported in operations in the year of settlement.

       Advertising and promotion expense-

       The costs of advertising, promotion and marketing programs are charged to
       operations in the year incurred.

       Income taxes-

       The  Company is treated as a  partnership  for federal and New York State
       income tax purposes and does not incur income  taxes.  The  Company's net
       income or loss is passed to the respective  members and is required to be
       reported by them on their income tax returns.

2.   Related Party Transactions:

     The Company  conducts its Rockland  County  operations from facilities that
     are leased from the sole stockholder of Kyto  Diagnostics,  Inc., a partner
     of one of the  Members  of the  Company.  Rent  expensed  and  paid to this
     related party was $270,770 for the year ended December 31, 1998.

3.   401(k) Plan:

     The Company  has a 401(k) plan which  covers  substantially  all  full-time
     employees who meet the plan's  eligibility  requirements and provides for a
     tax-deferred   profit-sharing   contribution   by   the   Company   and  an
     employee-elective  contribution.  The matching  contribution  limit for the
     Company  includes  20% of salary  reductions  up to 5% of  compensation.  A
     participant's 


                                       6
<PAGE>

     contribution  may not  exceed  20% of annual  compensation  or the  maximum
     amount  allowed as  determined by the Internal  Revenue Code,  whichever is
     smaller. The Company's contribution to the plan was $37,637 in 1998.

4.   Concentrations of Credit Risk:

     Financial   instruments   that   potentially   subject   the   Company   to
     concentrations of credit risk consist principally of cash.

     The Company  maintains cash balances at a bank located in the New York City
     area.  Accounts at the bank are insured by the  Federal  Deposit  Insurance
     Corporation up to $100,000.  At December 31, 1998, the Company's  uninsured
     cash balances totaled $832,175.

5.   Fair Value of Financial Instruments:

     At December 31, 1998, the carrying value of financial  instruments  such as
     cash, trade receivables and payables, approximated their fair values, based
     on the short-term maturities of these instruments.

6.   Leasing Arrangements:

     The Company has two operating lease  agreements  involving their office and
     laboratory facilities. The leases are noncancellable and expire in 1999 and
     2003.

     The following is a five-year  schedule of future  minimum  rental  payments
     required  under  the  operating  leases  that  have  initial  or  remaining
     noncancellable lease terms in excess of one year as of December 31, 1998:

Year Ended December 31, 1999               $269,967
Year Ended December 31, 2000                258,767
Year Ended December 31, 2001                263,942
Year Ended December 31, 2002                269,221
Year Ended December 31, 2003                135,943

     Rent expense for the year ended December 31, 1998 was $470,691.

7.   Contingencies:

     The Company is subject to various legal  proceedings and claims which arise
     in the ordinary course of its business.  In the opinion of management,  the
     amount  of  ultimate  liability  with  respect  to these  actions  will not
     materially affect the financial position of the Company,  as any judgements
     against the Company are expected to be  substantially  covered by insurance
     in effect at the time the claim was incurred.


                                       7
<PAGE>





8.   Subsequent Events:

     On January 6,  1999,  the  Company  signed a Letter of Intent  with  Dianon
     Systems, Inc. to sell substantially all of the assets used in connection of
     the  operation of the  Company's  business  including  its customer  lists,
     customer  files  and  records,  all  tangible  assets  such  as  equipment,
     furniture  and  fixtures,  and the rights to the trade name "Kyto  Meridien
     Diagnostics." The Company's accounts  receivable as of the date of sale are
     to be excluded from the transaction.

     It is projected that the sale will close on or about April 1, 1999.


                                       8
<PAGE>



                      KYTO MERIDIEN DIAGNOSTICS, L.L.C.


                        SCHEDULE OF COST OF OPERATIONS

                     FOR THE YEAR ENDED DECEMBER 31, 1998




LABOR                                                               $3,652,032
                                                                    ----------
LABORATORY SUPPLIES                                                 1,434,474
                                                                    ----------
OUTSIDE LABORATORY SERVICES                                           397,672
                                                                    ----------
OTHER COSTS:
  Payroll taxes                                                       282,155
  Group insurance                                                     172,111
  Workers' compensation insurance                                      35,640
  401(k) plan contribution                                             22,697
  Employee benefits                                                     5,866
  Education and seminars                                                5,338
  Malpractice insurance                                               208,351
  Licenses and permits                                                 46,755
  Postage, freight and delivery                                       697,150
  Shipping supplies                                                    30,465
  Repairs and maintenance - Laboratory equipment                       10,961
  Hazardous waste removal                                              33,492
                                                                    ----------
                                                                    1,550,981
                                                                    ----------
                                                                   $7,035,159
                                                                   ==========






                                       9
<PAGE>








                      KYTO MERIDIEN DIAGNOSTICS, L.L.C.


                        SCHEDULE OF OPERATING EXPENSES

                     FOR THE YEAR ENDED DECEMBER 31, 1998


GENERAL AND ADMINISTRATIVE EXPENSES:
  Salaries and wages                                               
                                                                   $2,088,635
  Amortization                                                         11,132
  Auto expenses                                                        26,418
  Bad debts                                                         1,296,815
  Billing and reporting supplies                                       86,815
  Collection agency fees                                               29,163
  Computer supplies and support                                       116,997
  Computer payroll service                                              7,943
  Depreciation                                                        128,910
  Employee benefits                                                     8,364
  401(k) plan contributions                                            13,016
  Group insurance                                                     175,392
  General insurance                                                    14,140
  New York State use tax                                               13,089
  New York State L.L.C. annual fee                                        325
  Office supplies and expense                                          92,987
  Payroll taxes                                                       206,775
  Professional fees                                                    47,310
  Rent                                                                470,691
  Repairs and maintenance                                              43,949
  Telephone                                                           119,869
  Travel and entertainment                                             14,935
  Utilities                                                            49,915
                                                                    ----------
                                                                   $5,063,585
                                                                   ===========

SELLING EXPENSES:
  Salaries and commissions                                          
                                                                     $330,053
  Payroll taxes                                                        18,631
  Auto expenses                                                        32,275
  401(k) plan contributions                                             1,924
  Group insurance                                                       8,354
  General insurance                                                       717
  Office supplies and expense                                             908
  Telephone                                                             4,021
  Travel and entertainment                                              7,401
                                                                    ----------
                                                                    $ 404,284
                                                                    =========



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