ORGANOGENESIS INC
4, 1998-09-03
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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<TABLE> 
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<S>                      <C>                                                       <C> 
+--------+
| FORM 4 |                       U.S. SECURITIES AND EXCHANGE COMMISSION                 /------------------------------/
+--------+                               WASHINGTON, D.C. 20549                          /        OMB APPROVAL          /
                                                                                         /------------------------------/
[_] Check this box if                                                                    / OMB Number:        3235-0287 /
    no longer subject         STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP               / Expires:  September 30, 1998 /
    to Section 16.                                                                       / Estimated average burden     /
    Form 4 or Form 5       Filed pursuant to Section 16(a) of the Securities             / hours per response...... 0.5 /
    obligations may           Exchange Act of 1934, Section 17(a) of the                 /------------------------------/ 
    continue. See            Public Utility Holding Company Act of 1935 or   
    Instruction 1(b).      Section 30(f) of the Investment Company Act of 1940
</TABLE> 

(Print or Type Responses)
 
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1.  Name and Address of Reporting Person*

    Rovee                            David                            T.
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        (Last)                      (First)                        (Middle)
        c/o Organogenesis Inc.
        150 Dan Road
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                                   (Street)

        Canton                      MA                                02021
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        (City)                      (State)                           (Zip)


2.  Issuer Name and Ticker or Trading Symbol      Organogenesis Inc. "ORG"
                                             -----------------------------------

3.  IRS or Identification Number of Reporting Person if an entity 
    (Voluntary)   
                --------------

4.  Statement for Month/Year               September / 1998   
                             ---------------------------------------------------

5.  If Amendment, Date of Original (Month/Year)
                                               ---------------------------------

 
6.  Relationship of Reporting Person(s) to Issuer (Check all applicable)
                                               

    [X] Director    [X] Officer              [_] 10% Owner    [_] Other
                        (give title below)                       (specify below)
        President and Chief Operating Officer
    ----------------------------------------------------------------

7.  Individual or Joint/Group Filing (Check Applicable Line)
    
    __X__ Form filed by One Reporting Person
    _____ Form filed by More than One Reporting Person

TABLE I--NON-DERIVATIVE SECURITIES ACQUIRED, DISPOSED OF, OR BENEFICIALLY OWNED

<TABLE> 
<CAPTION> 
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1. Title              2. Trans-  3. Trans-       4. Securities Acquired (A)        5. Amount of         6. Owner-     7. Nature
   of                    action     action          or Disposed of (D)                Securities           ship          of In-
   Security              Date       Code            (Instr. 3, 4 and 5)               Beneficially         Form:         direct
   (Instr. 3)            (Month/    (Instr. 8)                                        Owned at             Direct        Bene-
                         Day/    -----------------------------------------------      End of               (D) or        ficial
                         Year)                                                        Month                Indirect      Owner-
                                                               (A) or                 (Instr. 3 and 4)     (I)           ship
                                   Code       V   Amount       (D)       Price                             (Instr. 4)    (Instr. 4)
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<S>                   <C>        <C>         <C> <C>           <C>       <C>       <C>                  <C>           <C>

Common Stock           9/2/98     P                500          A        $10.4375      500                 D             
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</TABLE> 
Reminder: Report on a separate line for each class of securities beneficially 
owned directly or indirectly. 
* If this form is filed by more than one reporting person, see Instruction 
  4(b)(v).
<PAGE>
 
FORM 4 (continued)

  TABLE II--DERIVATIVE SECURITIES ACQUIRED, DISPOSED OF, OR BENEFICIALLY OWNED
        (e.g., puts, calls, warrants, options, convertible securities)

<TABLE> 
<CAPTION> 
- -----------------------------------------------------------------------------------------------------------------------------
 1. Title of Derivative            2. Conver-          3. Trans-           4. Transac-            5. Number of Deriv-        
    Security (Instr. 3)               sion or             action              tion Code              ative Securities        
                                      Exercise            Date                (Instr. 8)             Acquired (A) or         
                                      Price of            (Month/                                    Disposed of (D)         
                                      Deriv-              Day/                                       (Instr. 3, 4, and 5)    
                                      ative               Year)                                                              
                                      Security                                                                               

                                                                           ---------------------------------------------------
                                                                           Code      V                 (A)         (D)        
- -----------------------------------------------------------------------------------------------------------------------------
<S>                                <C>                 <C>                 <C>       <C>          <C>              <C> 
                             
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</TABLE> 

 TABLE II--DERIVATIVE SECURITIES ACQUIRED, DISPOSED OF, OR BENEFICIALLY OWNED
   (e.g., puts, calls, warrants, options, convertible securities)--CONTINUED
<TABLE> 
<CAPTION> 
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                              6. Date Exer-     7. Title and Amount of       8. Price    9. Number       10. Owner-    11. Na-
                                 cisable and       Underlying Securities        of          of Deriv-        ship          ture
                                 Expiration        (Instr. 3 and 4)             Deriv-      ative            Form          of In-
                                 Date                                           ative       Secur-           of De-        direct
                                 (Month/Day/                                    Secur-      ities            rivative      Bene-
                                 Year)                                          ity         Bene-            Secu-         ficial
                                                                                (Instr.     ficially         rity:         Owner-
                               --------------------------------------------     5)          Owned            Direct        ship
                               Date     Expira-              Amount or                      at End           (D) or        (Instr. 
                               Exer-    tion         Title   Number of                      of               Indi-         4)
                               cisable  Date                 Shares                         Month            rect (1)
                                                                                            (Instr. 4)       (Instr. 4)
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<S>                           <C>       <C>     <C>          <C>             <C>         <C>             <C>           <C> 

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</TABLE>           

Explanation of Responses:

**Intentional misstatements or omissions of facts constitute Federal Criminal
  Violations. 
  See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note:  File three copies of this Form, one of which must be manually signed.
       If space provided is insufficient, see Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained
in this form are not required to respond unless the form displays a currently 
valid OMB Number.

                                 /s/ DAVID T. ROVEE                9/2/98
                              -------------------------------  -----------------
                              **Signature of Reporting Person        Date


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