INSURED MUNICIPALS INCOME TR & INVS QUAL TAX EX TR MUT SE 16
497J, 1999-02-26
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February 26, 1999
Securities and Exchange Commission
450 Fifth Street, N.W.
Washington, D.C.  20549-1004

Attn:  Filing Desk - Stop 1-4
RE: Insured Municipals Income Trust and Investors' Quality 
Tax-Exempt Trust, Multi-Series 16

     File No. 33-02238     CIK #785799

Ladies/Gentlemen:

         In accordance with the provisions of Rule 497(j) of Regulation C under
the Securities Act of 1933 (the "Securities Act") this letter serves to certify
that the most recent amendment to the Post-Effective of the subject Registration
Statement on Form S-6 for the above captioned Trust does not differ from that
which would have been filed pursuant to Rule 497(b) of the Securities Act.
Amendment No. 11 to the Post-Effective, which was the most recent amendment to
the Post-Effective of the Registration Statement, was filed electronically with
the Commission on February 22, 1999.

Very truly yours,


VAN KAMPEN FUNDS INC.


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