LIPOSOME CO INC
DEF 14A, 1998-04-13
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                                  April 13, 1998





TO:  All Stockholders

   You are cordially invited to attend the 1998 Annual Meeting of
the  Stockholders of The Liposome Company, Inc.,  which  will  be
held  at  The Holiday Inn, 1053 Route #1, Princeton,  New  Jersey
08540,  on  May  14, 1998, at 10:15 a.m.  Information  about  the
Annual Meeting, including a listing and discussion of the various
matters on which the stockholders will act, may be found  in  the
enclosed  formal  Notice of Annual Meeting  of  Stockholders  and
Proxy Statement.  The Company's Annual Report for the fiscal year
ended December 28, 1997 is also included.

   At  the  Annual  Meeting you will be asked to  (1)  elect  the
members of the Board of Directors, and (2) ratify the appointment
of   Coopers  &  Lybrand  L.L.P.  as  the  Company's  independent
accountants for the 1998 fiscal year.

   We  plan  to  give a slide presentation at the Annual  Meeting
highlighting the Company's recent progress and our future  plans.
Upon  adjournment of the meeting, the directors and  officers  of
the   Company  will  be  available  to  confer  informally   with
stockholders.

   We  hope that you will be able to attend the meeting.  Whether
or  not  you  plan to attend, please sign, date and  return  your
proxy promptly in the postage prepaid envelope provided.

                              Sincerely,



                              Charles A. Baker
                              Chairman,  President  and   Chief
                              Executive Officer

                   THE LIPOSOME COMPANY, INC.
                                
            NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                     TO BE HELD MAY 14, 1998


   The  Annual  Meeting of Stockholders of The Liposome  Company,
Inc.  (the "Company") will be held at The Holiday Inn, 1053 Route
#1,  Princeton, New Jersey 08540, on May 14, 1998, at 10:15  a.m.
for the following purposes:

      1.  To  elect  nine directors to serve during  the  ensuing
          year;
      
      2.  To  ratify  the appointment by the  Board  of
          Directors of Coopers & Lybrand L.L.P. as  the
          Company's  independent  accountants  for  the
          fiscal year 1998; and
      
      3.  To   transact  such  other  business  as  may
          properly  come  before the  meeting  and  any
          adjournment or postponement of the meeting.

  The Board of Directors has fixed the close of business on March
27,  1998,  as  the record date for determining the  stockholders
entitled to notice of, and to vote at the Annual Meeting and  any
adjournment or postponement of the meeting.

   All  stockholders are cordially invited to attend the meeting.
WHETHER  OR NOT YOU INTEND TO BE PRESENT, PLEASE COMPLETE,  DATE,
SIGN  AND  RETURN THE ENCLOSED PROXY CARD IN THE POSTAGE  PREPAID
ENVELOPE  ENCLOSED  FOR  YOUR CONVENIENCE.   If  you  attend  the
meeting, you can vote in person even if you have already returned
a   proxy   card.   Stockholders  can  help  the  Company   avoid
unnecessary expense and delay by promptly returning the  enclosed
proxy  card.   The business of the meeting cannot  be  transacted
unless  at  least  a  majority  of  the  outstanding  shares  are
represented at the meeting.

                              By Order of the Board of Directors



                              CAROL J. GILLESPIE
                              Secretary
Princeton, New Jersey
April 13, 1998
                   THE LIPOSOME COMPANY, INC.

                         PROXY STATEMENT
                 ANNUAL MEETING OF STOCKHOLDERS
                          MAY 14, 1998
 --------------------------------------------------------------
                       GENERAL INFORMATION


  This Proxy Statement is being sent by the Board of Directors of
The Liposome Company, Inc. (the "Company") to solicit proxies for
the  Annual  Meeting of Stockholders to be held on May  14,  1998
(the "Annual Meeting").

   Each proxy will be voted as specified by the stockholder.  Any
duly executed proxy not specifying the contrary will be voted FOR
(i)  the  nine  directors nominated for election  at  the  Annual
Meeting, and (ii) the ratification of Coopers & Lybrand L.L.P. as
the  Company's independent accountants for the fiscal year  1998.
A  stockholder giving a proxy may revoke it by written notice  to
the  Secretary of the Company that is received at any time before
it  is  voted.  The address of the Company's principal  executive
offices   is  One  Research  Way,  Princeton  Forrestal   Center,
Princeton, New Jersey 08540.

  At the close of business on March 27, 1998, the record date for
the  Annual Meeting, there were outstanding and entitled to  vote
37,964,331 shares of Common Stock.  A quorum for purposes of  the
Annual  Meeting is fifty percent (50%) of the shares  outstanding
on  the  record date, or 18,982,165 shares.  Each share of Common
Stock entitles the holder to one vote, which the holder may  cast
either  in  person  or  by proxy.  Pursuant to  Delaware  General
Corporation  Law,  only  votes cast  "FOR"  a  matter  constitute
affirmative votes.  Votes "WITHHELD" or abstaining from voting on
one  or  more  proposals are counted for purposes of  determining
whether  enough shares are present to make up a quorum.   Because
votes "WITHHELD" from voting on a particular proposal are counted
in determining the number of shares voted on the proposal, a vote
"WITHHELD" will have the same effect as a vote cast "AGAINST" the
proposal.  On ordinary proposals, brokers have the right to  vote
shares that are held in their name or the name of a depository on
behalf   of   their  clients  if  they  do  not  receive   voting
instructions  from  the client within a certain  number  of  days
before  the  meeting.  However, if the proposals to be  voted  on
include  some  that are considered "special," the brokers  cannot
vote shares held for their clients on the special proposals.  The
shares  not  voted,  which  are called  "broker  non-votes,"  are
counted for purposes of making up a quorum but are not counted in
determining  the total number of votes cast on the  proposal  and
therefore  do not have the effect of negative votes.   Management
believes that both of the proposals to be voted on at the  Annual
Meeting would be considered ordinary.

  In the election of directors, the nine candidates receiving the
most votes will be elected.  Approval of Proposal 2 will require
the affirmative vote of a majority of the shares voted on the
proposal.  Votes will be tabulated preliminarily by the Company's
transfer agent, American Stock Transfer & Trust Co.  Inspectors
of Election, appointed by the Board of Directors, will finally
count and tabulate the votes and determine and announce the
results.

  A copy of the Annual Report of the Company, including financial
statements  and  a description of its operations for  the  fiscal
year 1997, accompanies this Proxy Statement.  Such report is  not
incorporated herein by reference.

Mailed to Stockholders on or about April 13, 1998

PROPOSAL 1.  ELECTION OF DIRECTORS

  Nine directors are to be elected at the Annual Meeting and will
serve  until  their  successors are elected.  All  are  currently
serving as directors.

   It  is  intended that proxies received will be voted  FOR  the
election  of  the  nominees  named below  unless  marked  to  the
contrary.   Each of the persons named has indicated  that  he  is
willing and able to be nominated and, if elected, to serve  as  a
director.   However, in the event that any of  these  persons  is
unwilling  or unable to serve at the time of the Annual  Meeting,
the  proxies may be voted either for the balance of the  nominees
named,   or  for  those  persons  and  for  substitute   nominees
designated  by  the  proxy holders or by  the  present  Board  of
Directors.  Proxies cannot be voted for more than nine nominees.

  Name                             Age  Position with the Company
Charles A. Baker                   65   Chairman of the Board,
                                        President,
                                        Chief Executive Officer and
                                        Director
James G. Andress (2)               59   Director
Morton Collins, PhD (1)            62   Director
Stuart F. Feiner (1)               49   Director
Robert F. Hendrickson (2)          65   Director
Professor Bengt Samuelsson,MD(1)   64   Director
Joseph T. Stewart, Jr. (2)         68   Director
Gerald Weissmann, MD (1)           67   Director
Horst Witzel, Dr.-Ing (2)          70   Director

(1)  Audit and Finance Committee member
(2)  Nominating and Compensation Committee member


Nominees for Election as Directors


  Charles A. Baker was named Chairman of the Board, President and
Chief  Executive Officer of the Company in December  1989.   Just
prior  to  joining the Company he was a business development  and
licensing advisor to several small biotechnology companies.   Mr.
Baker  has  served in several capacities in senior management  at
Squibb  Corporation (now Bristol-Myers Squibb Company), including
the  positions  of Group Vice President, Squibb  Corporation  and
President,  Squibb  International.   He  has  also  held  various
executive positions at Abbott Laboratories and Pfizer  Inc.   Mr.
Baker  received  an undergraduate degree from Swarthmore  College
and  a  J.D.  degree from Columbia University.   Mr.  Baker  also
serves  as  a  director  of Regeneron Pharmaceuticals,  Inc.  and
Progenics  Pharmaceuticals, Inc., both  biotechnology  companies.
He  is  a  member  of  the  Council of  Visitors  of  the  Marine
Biological  Laboratory,  Woods Hole,  Massachusetts,  a  not-for-
profit research organization.


   James G. Andress has been a director since his appointment  in
September  1990.   Mr.  Andress became the  President  and  Chief
Executive  Officer  of  Warner Chilcott,  plc,  a  pharmaceutical
company,  in November 1996, and Chairman in February 1998.   From
1989  until  1995,  he  served as President,  Co-Chief  Executive
Officer and a director of Information Resources, Inc., a decision
support  software  and consumer packaged goods research  company.
Mr.  Andress is the former Chairman of the Pharmaceuticals Group,
Beecham  Group, plc and the former President and Chief  Operating
Officer of Sterling Drug, Inc.  Mr. Andress is a director of XOMA
Corp.  and  NeoRx, Inc., which are biotechnology  companies.   He
also  serves  as  a  director of Sepracor,  Inc.,  a  separations
technology  company; of O.P.T.I.O.N. Care, Inc.,  a  home  health
care  company;  of  Favorite Brands, a  consumer  packaged  goods
company;  of  Allstate  Insurance  Company;  and  of  Information
Resources, Inc.


   Morton Collins, Ph.D. has been a director since November 1982.
Dr.  Collins  has been a General Partner of DSV Partners  III,  a
venture  capital limited partnership, since 1981  and  a  General
Partner  of  DSV Management, Ltd., since 1982.  Since  1985,  DSV
Management, Ltd. has been a General Partner of DSV Partners IV, a
venture  capital  limited partnership.   Dr.  Collins  served  as
interim Chairman of the Board and Chief Executive Officer of  the
Company  from June to December, 1989.  He is also a  director  of
ThermoTrex  Corporation, a laser and electro-optics company,  and
of Kopin Corporation, a manufacturing company.


   Stuart F. Feiner has been a director since February 1984.  Mr.
Feiner  has  been Executive Vice President, General  Counsel  and
Secretary  of  Inco Limited, an international mining  and  metals
company, since August 1993 and served as Vice President,  General
Counsel  and Secretary of that company from April 1992 to  August
1993.    Mr.  Feiner  was  President  of  Inco  Venture   Capital
Management,  the  venture  capital unit  of  Inco  Limited,  from
January  1984  to April 1992.  Mr. Feiner is also a  director  of
ImmunoGen, Inc., a biotechnology company.


   Robert F. Hendrickson has been a director of the Company since
1992.   Mr.  Hendrickson was Senior Vice President, Manufacturing
and  Technology for Merck & Co., Inc., a pharmaceutical  company,
from  1985  to  1990.   Since 1990, Mr. Hendrickson  has  been  a
manufacturing  consultant  with a  number  of  biotechnology  and
pharmaceutical  companies among his clients.  He is  currently  a
director   of  Envirogen  Inc.,  an  environmental  biotechnology
company,  and  of  Cytogen Corporation and Unigene  Laboratories,
Inc., both of which are biotechnology companies, and a trustee of
the Carrier Foundation.


   Professor  Bengt Samuelsson, M.D. has been a director  of  the
Company  since  January  1994.  Dr. Samuelsson  is  Professor  of
Physiological   Chemistry   of  the  Karolinska   Institutet   in
Stockholm,  Sweden, a position that he has held since  1972.   He
was  one  of three recipients who shared the 1982 Nobel Prize  in
medicine  for  their  work  on prostaglandins,  specifically  the
discovery  of prostanoids and leukotrienes.  In addition  to  the
Nobel  Prize,  he  has  received a number  of  other  prestigious
awards.   He  has  been a member of the Company's  Cell  Adhesion
Scientific  Advisory Board since May, 1991.   Dr.  Samuelsson  is
Chairman  of  the  Nobel Foundation, a member  of  the  Board  of
Directors of Pharmacia & Upjohn, a pharmaceutical company, and  a
member  of  the  Board of Directors of Handelsbanken,  Stockholm,
Sweden, a Swedish bank.


  Joseph T. Stewart, Jr. has been a director of the Company since
January 1995.  Until 1989, he was associated for twenty-two years
with  Squibb  Corporation,  where he held  several  positions  of
increasing  responsibility, including most recently  Senior  Vice
President,  Corporate  Affairs  and  previously  Vice  President,
Finance and Planning.  He also served as a member of the Board of
Directors  of  Squibb Corporation.  He is currently an  executive
consultant  to Johnson & Johnson, a director of General  American
Investors Company, Inc., and a trustee of the Foundation  of  the
University of Medicine and Dentistry of New Jersey.  He is also a
trustee  of  the  New School University and is a  member  of  the
Council  of  Visitors of the Marine Biological Laboratory,  Woods
Hole, Massachusetts, a not-for-profit research organization.


  Gerald Weissmann, M.D. has been a director of the Company since
1981.   Dr.  Weissmann has been a Professor of  Medicine  at  the
Division  of  Rheumatology of the Department of Medicine  at  New
York  University  Medical Center since 1973.   Dr.  Weissmann  is
Chairman of the Company's Cell Adhesion Scientific Advisory Board
and  the Company's Cancer Scientific Advisory Board.  He is  also
on  the  Board  of Trustees of the Marine Biological  Laboratory,
Woods    Hole,    Massachusetts,   a   not-for-profit    research
organization.


   Dr. Horst Witzel has been a director of the Company since July
1990.   Dr.  Witzel  is  the  former Chairman  of  the  Board  of
Executive  Directors of Schering AG, Berlin, Germany.  After  his
retirement in 1989 he served as a member of the Supervisory Board
of  Schering  AG until May 1994.  Dr. Witzel is a member  of  the
Supervisory  Board of Brau und Brunnen AG, Berlin  and  Dortmund,
Germany.   He  is  a director of Cephalon, Inc.,  a  neuroscience
company,  and  Aastrom  Biosciences,  Inc.,  a  cellular  therapy
medical products company.



Committees of the Board of Directors



  The  Board of Directors has two standing committees:  the Audit
and   Finance  Committee  and  the  Nominating  and  Compensation
Committee.   Stockholders desiring to submit recommendations  for
nominees   to  the  Board  of  Directors  should  address   their
recommendations in writing to the Chairman of the Nominating  and
Compensation Committee.


  The Audit and Finance Committee consists of Dr. Morton Collins,
Mr.  Stuart  F.  Feiner, Prof. Bengt Samuelsson,  M.D.,  and  Dr.
Gerald  Weissmann.  This committee provides advice and assistance
to  the  Company  regarding accounting,  auditing  and  financial
reporting.   The  Audit and Finance Committee also  recommends  a
firm  of certified public accountants, whose duty it is to  audit
the  books  and accounts of the Company for the fiscal  year  for
which they were appointed, and monitors the effectiveness of  the
audit   effort   and  the  Company's  financial  and   accounting
organization  and  financial reporting.  The  Audit  and  Finance
Committee  held 3 meetings during the fiscal year ended  December
28,  1997.   No member of the Audit and Finance Committee  is  an
officer or employee of the Company.


  The Nominating and Compensation Committee consists of Mr. James
G.  Andress, Mr. Robert F. Hendrickson, Mr. Joseph T. Stewart and
Dr.  Horst  Witzel.   Its functions are to propose  and  evaluate
nominees  for  the Board of Directors, to propose  candidates  to
serve as successor to the Chief Executive Officer, to review  and
approve  salaries and other matters relating to  compensation  of
all  officers  and  employees of the Company  above  a  specified
salary level, to review and make recommendations to the Board  of
Directors  for compensation and benefit plans and practices,  and
to   administer  certain  benefit  plans  of  the  Company.   The
Nominating  and Compensation Committee also reviews and  approves
grants  of options to employees and consultants who are not  also
directors  of  the  Company.  Option grants to  persons  who  are
directors  of the Company are reviewed and approved by the  Board
of   Directors.   The  nominating  function  was  added  to   the
committee's responsibilities and the composition of the committee
was changed in November 1997.  The Compensation Committee held  6
meetings during the fiscal year ended December 28, 1997, and  one
meeting  was  held by the Nominating and Compensation  Committee.
No  member  of  the Nominating and Compensation Committee  is  an
officer or employee of the Company.


  The  Company's  Board of Directors held 9 meetings  during  the
fiscal year ended December 28, 1997.  No director attended  fewer
than  75 percent of the aggregate number of meetings of the Board
of Directors or of Committees on which he served.


Stock Ownership



   The  following table sets forth certain information  regarding
the  beneficial  ownership of the Company's Common  Stock  as  of
February  25,  1998,  by (i) each director  and  Named  Executive
Officer  of  the  Company (as defined under the section  entitled
"Executive  Compensation"), (ii) each stockholder  known  by  the
Company  to own more than five percent of the outstanding  Common
Stock,  and (iii) all directors and executive officers, including
the  Named  Executive Officers, as a group.  Except as  otherwise
indicated, the Company believes that the beneficial owners of the
securities listed below, based on information furnished  by  such
owners, have sole investment and voting power with respect to the
shares of Common Stock shown as being beneficially owned by them.

Beneficial Owner                Number of Shares      Percent of Total
Ross Financial Corporation(1)
POB 31363-SMB
Cayman Islands, BWI               9,353,346                   24.83

Charles A. Baker (2)(3)(4)(6)       572,054                    1.52
James G. Andress (2)                 60,000                     *
Morton Collins, PhD (2)              60,000                     *
Stuart F. Feiner (2)                 31,000                     *
Robert F. Hendrickson (2)            50,000                     *
Professor Bengt Samuelsson, MD (2)   48,000                     *
Joseph T. Stewart, Jr. (2)           21,000                     *
Gerald Weissmann, MD (2)(5)          58,334                     *
Horst Witzel, Dr-Ing (2)             85,000                     *
James A. Boyle, MD, PhD (2)(4)(6)   146,485                     *
Ralph del Campo (2)(4)(6)           111,793                     *
Andrew S. Janoff, PhD (2)(4)(6)      57,386                     *
Donald D. Yarson (4)(6)              41,844                     *
All Directors and Executive       1,548,384                  4.11
Officers as a group (17 persons)
(2)(4)(6)

*Less than 1.0 percent
______________________________
(1)     Based on information filed with the SEC on Schedule  13D
  by  Ross Financial Corporation for the year ended December 31,
  1997.   Mr.  Kenneth  B. Dart is the sole shareholder  of  STS
  Inc.,   which  is  the  sole  shareholder  of  Ross  Financial
  Corporation.   Mr. Dart may, therefore, be deemed  to  be  the
  beneficial  owner  of  the  shares  held  by  Ross   Financial
  Corporation.

(2)     Includes  shares  of  Common  Stock  issuable  upon  the
  exercise  of  outstanding options granted under the  Company's
  stock  option plans which are exercisable within 60 days after
  February  25,  1998,  as  follows:  Mr.  Baker,  234,836;  Mr.
  Andress, 60,000; Dr. Collins, 35,000; Mr. Feiner, 30,000;  Mr.
  Hendrickson,  30,000;  Dr. Samuelsson,  48,000;  Mr.  Stewart,
  17,000; Dr. Weissmann, 28,334; Dr. Witzel, 85,000; Dr.  Boyle,
  108,600;  Mr. del Campo, 81,000; Dr. Janoff, 29,836;  and  all
  executive  officers  and directors as a  group  (17  persons),
  935,220.

(3)    Includes 202,093 shares owned by the Baker Family Limited
  Partnership, of which Mr. Baker is the General Partner.

(4)     Includes shares held by Chemical Bank as trustee of  the
  Company's  401(k)  plan  as  of  December  31,  1997,  in  the
  following  amounts:   Mr.  Baker,  3,776;  Dr.  Boyle,  1,174;
  Mr.  del  Campo, 2,575; Dr. Janoff, 3,534; Mr. Yarson,  1,870;
  and  all  executive  officers and directors  as  a  group  (17
  persons), 21,461.

(5)     Does  not  include 5,790 shares held in  trust  for  the
  estate   of   Dr.   Weissmann's   father-in-law,   for   which
  Dr.   Weissmann's  wife  serves  as  trustee.   Dr.  Weissmann
  disclaims beneficial ownership of these shares.

(6)     Includes  shares of restricted stock granted on  January
  25,  1996,  January 23, 1997, and January 22, 1998, under  The
  Liposome  Company 1996 Equity Incentive Plan, in the following
  aggregate  amounts:   Mr. Baker, 53,278;  Dr.  Boyle,  29,661;
  Mr.  del  Campo,  28,518;  Dr.  Janoff,  24,125;  Mr.  Yarson,
  40,199;  all executive  officers and directors as a group  (17
  persons), 225,242.

Executive Compensation


The following table shows, for the fiscal years ended December
28, 1997, December 29, 1996, and December 31, 1995, the annual
and  long-term compensation awarded to, earned by or  paid  to
the  Chief  Executive Officer, and the four other most  highly
compensated individuals who served as the Company's "executive
officers," as that term is defined in Rule 3b-7 adopted by the
United States Securities and Exchange Commission ("SEC") under
the  Securities Exchange Act of 1934, as of December 28,  1997
(these individuals, together with the Chief Executive Officer,
are sometimes referred to as the "Named Executive Officers").
  
                   SUMMARY COMPENSATION TABLE
                                
                           ANNUAL          LONG-TERM
                        COMPENSATION     COMPENSATION
                                            AWARDS
                                                                
                                         RESTRICTED  SECURITIES       
                                         STOCK       UNDERLYING  ALL OTHER
                         SALARY   BONUS  AWARD(S)    STOCK       COMPENSATION
NAME AND PRINCIPAL  YEAR   $      (1)     (2)        OPTIONS     (4)
     POSITION                      $       $         (NO. OF      $
                                                     SHARES)
                                                               
Charles A. Baker    1997 $375,000 $40,000  ---      281,000(3)   $9,500
Chairman of the     1996  351,923  75,000  75,000    60,000       9,490
Board, President,   1995  321,847  90,000  ---       70,000       4,500
and Chief Executive 
Officer
                                                               
James A. Boyle, MD, 1997  252,253  12,500  12,500    48,800(3)    9,500
PhD, Senior Vice    1996  241,714  50,000  50,000    13,500       9,490
President, Medical  1995  225,394  30,000  29,993    22,500      35,000
and Regulatory   
Affairs          
                                                               
Ralph del Campo     1997  193,889  11,000  11,000    44,800(3)    9,500
Vice President,     1996  183,796  40,000  40,000    13,500       9,490
Manufacturing       1995  172,745  20,000  19,869    17,500       4,500
Operations 
                                                               
Andrew S. Janoff,   1997  186,923  11,000  11,000    43,600(3)    9,500
PhD, Vice           1996  172,300  40,000  40,000    11,500       9,490
Research and        1995  147,416  11,250  11,250    13,000       4,422
Development
                                                                   
Donald D. Yarson(5) 1997  181,873  13,750  13,750   120,000 (3)   9,500
Vice President,     1996  139,330  65,000  50,000    19,000       8,634
Marketing, Sales    1995  121,829  15,000  15,000    57,500       3,655
and Business 
Development

(1)Bonuses,  all  of which have been paid, are  shown  in  the
   year earned.

(2)All  restricted stock grants were made on January 25, 1996,
   January  23, 1997, and January 22, 1998, under The Liposome
   Company  1996 Equity Incentive Plan.  The aggregate  number
   of  shares held by the Named Executive Officers at the  end
   of  1997  (and their market value as of December 28,  1997)
   were:    Mr.  Baker,  3,278  ($14,652);  Dr.  Boyle,  3,533
   ($15,792);  Mr.  del  Campo, 2,646 ($11,827);  Dr.  Janoff,
   2,253  ($10,070); and Mr. Yarson, 2,859 ($12,779).  All  of
   these  grants  vest in equal increments over  a  three-year
   period.   The number of shares awarded in 1998 as  part  of
   the  bonus  for  1997  were:  Dr. Boyle,  2,128;  Mr.  del
   Campo,  1,872; Dr. Janoff, 1,872; and Mr. Yarson, 2,340.
   These  grants  vest in two equal annual installments.   For
   further information regarding restricted stock awards,  see
   the  "Report  of the Nominating and Compensation  Committee
   on Executive Compensation."

(3)The   numbers  shown  for  securities  underlying   options
   awarded  in  1997  include the number of shares  underlying
   options  that  were  repriced in 1997, as  well  as  shares
   subject to new options awarded in 1997, in accordance  with
   the  requirements of the SEC.  In order to qualify for  the
   repricing,  each  optionee, including each Named  Executive
   Officer,  was  required  to surrender  20%  of  the  shares
   covered  by  the  options  to  be  repriced.   Since   this
   surrender  reduced  the total number of shares  covered  by
   options  held  by  the Named Executive  Officers,  the  net
   increase  in the total number of shares covered by  options
   held  by  these  individuals was  actually  less  than  the
   number  of shares underlying new options awarded  in  1997.
   See  note  1 to the table entitled "Option Grants  in  1997
   Fiscal  Year"  and the table entitled "Ten-Year  Option/SAR
   Repricings."

(4)All  other  compensation  represents  amounts  credited  as
   Company  matching contributions under the Company's  401(k)
   stock  match  (which began in the third quarter  of  1991).
   In  the  case  of  Dr. Boyle, the amount reported  as  "all
   other  compensation"  for  1995  consists  entirely  of   a
   payment  made  at the end of his first year  of  employment
   pursuant to an agreement entered into when he was hired.

(5)Mr. Yarson commenced employment with the Company on February
   1, 1995.

Employment Agreements and Change of Control Arrangements


 The Company entered into an employment agreement with Mr. Baker
which  began  in  December 1989 and was renewed  in  1995.   The
renewed agreement terminates on May 31, 1998, and may be renewed
thereafter  for one or more additional terms of one  year.   The
terms of the agreement relating to compensation are discussed in
the  "Report  of  the Nominating and Compensation  Committee  on
Executive  Compensation."  Under the agreement,  Mr.  Baker  has
agreed that he will not during his employment period and  for  a
period  of  two  years after the termination of his  employment,
without  the prior approval of the Company's Board of Directors,
engage  in  any business involved in the research,  development,
manufacture  or  sale  of  lipids or liposomes  or  products  or
services which use natural or artificial lipids or liposomes  to
encapsulate,  enhance  or deliver any  product.   If  Mr.  Baker
should  be dismissed except for cause or should choose to resign
from  his position with the Company during the first six  months
following  the effective date of a change of control, Mr.  Baker
would  be  entitled  to  receive his then current  monthly  base
salary for a 12-month period from such effective date and for up
to  an  additional 12-month period if he does not obtain another
full-time  position.  In addition, all stock options granted  to
Mr.  Baker which would have vested during the remainder  of  his
employment  term  would  automatically  vest  and  would  remain
exercisable  for a period of 24 months following the termination
of  his  employment.  A change of control is deemed to occur  if
(i)  the Company is not the surviving entity following a  merger
or   consolidation;   (ii)  a  person  acquires,   directly   or
indirectly, securities of the Company representing 35%  or  more
of  the  voting power of all then outstanding securities of  the
Company  having  the right to elect the Board of  Directors;  or
(iii)  the individuals who constitute the Board of Directors  of
the  Company at the time of the agreement or individuals who are
subsequently elected to the Board of Directors with the approval
of  the  incumbent Board cease to constitute a majority  of  the
members of such Board.

  In January 1998, upon the recommendation of the Nominating and
Compensation  Committee,  the Board authorized  the  Company  to
enter  into  agreements  with certain  officers  and  other  key
employees,  including the Named Executive Officers,  that  would
provide  for a continuation of the officer's salary and benefits
if  he  or she were terminated following a change of control  of
the Company.  The agreements give an officer whose employment is
terminated involuntarily (except for cause), or who resigns with
good  reason,  within 18 months after a change  of  control  the
right to receive his or her base salary, bonus, and benefits for
a  period  of 12 months following the termination of employment.
A  "change  of  control"  for purposes of  these  agreements  is
substantially  the same as described above with respect  to  the
Chief  Executive Officer's employment agreement.  The agreements
also  provide outplacement assistance and reimbursement  of  any
federal  excess  parachute tax that  might  be  imposed  on  the
officer.
  
  
Option Grants



   The  following  table presents stock options granted  for  the
period from December 30, 1996, through December 28, 1997, to  the
Named  Executive  Officers.   All  grants  were  made  under  The
Liposome Company 1996 Equity Compensation Plan.
                                
                OPTION GRANTS IN 1997 FISCAL YEAR
                                
                                                                 
                                                             POTENTIAL
                                                            REALIZABLE
                                                             VALUE AT
                                                          ASSUMED ANNUAL
                    INDIVIDUAL GRANTS                     RATES OF STOCK
                                                               PRICE
                                                           APPRECIATION
                                                            FOR OPTION
                                                             TERM (2)
                              PERCENT OF                               
                 NUMBER OF   TOTAL                                  
                 SECURITIES  OPTIONS                                 
                 UNDERLYING  GRANTED TO  EXERCISE                      
                 OPTIONS     EMPLOYEES   PRICE    EXPIRA-             
      NAME       GRANTED     IN FISCAL   ($ PER   TION        5%     10%
                  (1)        YEAR        SHARE)   DATE        ($)     ($)
                  (#)         (%)     
                  
Charles A. Baker  24,000      .68       $8.0000   11/8/01  $120,576 $305,472
                  28,000      .80        8.0000  12/22/02   140,672  356,384
                  56,000     1.60        8.0000   11/8/05   281,344  712,768
                  48,000     1.37        8.0000   12/5/06   241,152  610,944
                  50,000     1.43        8.0000   7/10/07   251,200  636,400
                  75,000     2.15        4.9375  12/19/07   232,556  589,167

James A. Boyle,   18,000      .51        8.0000   11/8/05    90,432  229,104
MD, PhD           10,800      .30        8.0000  11/21/06    54,259  137,462
                  20,000      .57        8.0000   7/10/07   100,480  254,560

Ralph del Campo   14,000      .40        8.0000   11/8/05    70,336  178,192
                  10,800      .30        8.0000  11/21/06    54,259  137,462
                  20,000      .57        8.0000   7/10/07   100,480  254,560

Andrew S. Janoff,  4,000      .11        8.0000  11/19/02    20,096   50,912
PhD               10,400      .29        8.0000   11/8/05    52,249  132,371
                   9,200      .26        8.0000  11/21/06    46,220  117,097
                  20,000      .57        8.0000   7/10/07   100,480  254,560

Donald D. Yarson  28,800      .82        8.0000    2/1/05   144,691  366,566
                   6,000      .17        8.0000   11/8/05    30,144   76,368
                  15,200      .43        8.0000  11/21/06    76,364  193,465
                  20,000      .57        8.0000   7/10/07   100,480  254,560
                  50,000     1.43        8.0000   7/24/07   251,200  636,400

(1)The   numbers  shown  for  securities  underlying   options
   awarded  in  1997  include the number of shares  underlying
   options  that  were  repriced in 1997, as  well  as  shares
   subject to new options awarded in 1997, in accordance  with
   the  requirements of the SEC.  In order to qualify for  the
   repricing,  each  optionee, including each Named  Executive
   Officer,  was  required  to surrender  20%  of  the  shares
   covered  by  the  options  to  be  repriced.   Since   this
   surrender  reduced  the total number of shares  covered  by
   options  held  by  the Named Executive  Officers,  the  net
   increase  in the total number of shares covered by  options
   held  by  these  individuals was  actually  less  than  the
   number  of shares underlying new options awarded  in  1997.
   The  following  table sets forth (a) the number  of  shares
   surrendered  by  each  Named  Executive  Officer   in   the
   repricing, (b) the number of shares subject to new  options
   granted in 1997, and (c) the resulting net increase in  the
   number  of  shares subject to options held  by  each  Named
   Executive  Officer (exclusive of other changes in  holdings
   due to option expirations and exercises, if any):

               NET 1997 INCREASE IN OPTION SHARES
                                
                        REPRICED OPTIONS                              
                                                     NUMBER OF      
                  NUMBER    NUMBER     DECREASE      SECURITIES  NET
                    OF      OF         IN NUMBER     UNDERLYING  INCREASE IN
                 SECURITIES SECURITIES OF            OTHER       NUMBER
                 UNDERLYING UNDERLYING SECURITIES    OPTIONS     OF
                 OPTIONS    OPTIONS    UNDERLYING    GRANTED     SECURITIES    
                 BEFORE     AFTER      OPTIONS DUE   IN          UNDERLYING
                 REPRICING  REPRICING  TO REPRICING  1997        OPTIONS

Charles A. Baker 195,000    156,000     39,000       125,000     86,000
                                                                 
James A. Boyle,   36,000     28,800      7,200        20,000     12,800
MD, PhD
                                                                
Ralph del Campo   31,000     24,800      6,200        20,000     13,800
                                                             
Andrew S. Janoff, 29,500     23,600      5,900        20,000     14,100
PhD
                                                                
Donald D. Yarson  62,500     50,000     12,500        70,000     57,500

                                                           
    Additional   information  regarding   the   repricing   is
    contained  in  the  table  entitled  "Ten-Year  Option/SAR
    Repricings."

(2)  The  percentage  rates of increase shown are  assumed  rates
     established  by the SEC for purposes of uniform compensation
     reporting.   Accordingly, they do not constitute predictions
     or estimates by the Company of the future price appreciation
     of  its Common Stock or of the potential realizable value of
     the  options  referred  to in the table.   These  "potential
     realizable values" are not discounted to present value,  and
     the  present  value  of  these assumed potential  realizable
     values would be less than the amounts indicated.

Option Exercises and Fiscal Year-End Values


 The following table summarizes stock options exercised by the
Named Executive Officers in 1997, and the unexercised stock
options and the fiscal year-end values of all outstanding options
held by the Named Executive Officers as of December 28, 1997.

   OPTION EXERCISES IN 1997 AND DECEMBER 28, 1997 OPTION VALUES

                                                                 
                                        NUMBER OF            VALUE OF
                                        UNEXERCISED          UNEXERCISED
                    1997 OPTION         OPTIONS              IN-THE-MONEY
                     EXERCISES          AT                   OPTIONS AT 
                                        DECEMBER 28,         DECEMBER 28,
                                        1997                 1997 (1)          
                 SHARES                                               
                 ACQUIRED  VALUE                                       
NAME             ON        REALIZED   EXERCIS- UNEXERCIS-  EXERCIS- UNEXERCIS-
                 EXERCISE  ($)        ABLE     ABLE        ABLE     ABLE
                 (#)       (2)         (#)      (#)         ($)      ($)
                 
                                                                      
Charles A. Baker 79,164  $254,938(3)  234,836  302,000    $514,991   ---
                 
James A. Boyle,   ---      ---        108,600  121,200      ---      ---
MD, PhD

Ralph del Campo   ---      ---         63,000   86,800      ---      ---

Andrew S.         ---      ---         24,836   54,518      ---      ---
Janoff, PhD

Donald D.        10,000     95,000        0    120,000      ---      ---
Yarson

(1)Value of unexercised in-the-money options is equal to the fair
 market  value  of $4.47 per share of Common Stock,  the  closing
 price  on  the last trading day prior to December 28,  1997,  as
 quoted by the Nasdaq National Market, less the exercise price.

(2)"Value realized" represents the difference between the exercise
 price  and the closing price on the date of exercise,  and  does
 not  necessarily represent actual appreciation realized on  sale
 of  the  shares underlying the options, or even that the  shares
 were sold.

(3)Mr.  Baker still holds the 79,164 shares that he purchased  on
 the  exercise  of  his  options and has therefore  not  actually
 realized any gain from his option exercise.

Option/SAR Repricings


  As  discussed  below  in  the "Report  of  the  Nominating  and
Compensation Committee on Stock Option Repricing,"  a  number  of
employee  stock options were repriced in July 1997.  In order  to
obtain  the  lower  exercise price, optionees  were  required  to
surrender  20%  of  the  shares  covered  by  each  option.   The
following  table  shows the number of optioned shares  that  were
repriced  for the Named Executive Officers, which represents  80%
of  the  number of shares that were covered by each option before
the  repricing.   This  table is called  a  "Ten-Year  Option/SAR
Repricings" table because SEC rules require the Company to report
all  repricings  of options held by the Named Executive  Officers
during  the  past  ten  years, but in fact there  were  no  other
repricings during that period.

                 TEN-YEAR OPTION/SAR REPRICINGS
                               
                                                                    LENGTH
                                                                    OF
                          NUMBER OF                                 ORIGINAL
                          SECURITIES  MARKET                        OPTION
                          UNDERLYING  PRICE OF   EXERCISE           TERM
                          OPTIONS/    STOCK AT   PRICE AT           REMAINING
                          SARS        TIME OF    TIME OF    NEW     AT DATE
                          REPRICED    REPRICING  REPRICING  EXER-   OF
                          OR          OR         OR         CISE    REPRICING
                          AMENDED     AMENDMENT  AMENDMENT  PRICE   OR
NAME             DATE     (#)(1)      ($)        ($)        ($)     AMENDMENT
                                                                 
Charles A. Baker 7/10/97  48,000     $8.00       $16.88      $8.00   9 years,
Chairman                                                             5 months
of the Board,    7/10/97  56,000      8.00        13.38       8.00   8 years,
President, and                                                       4 months
Chief            7/10/97  28,000      8.00        12.88       8.00   5 years,
Executive                                                            5 months
Officer          7/10/97  24,000      8.00        11.75       8.00   4 years,
                                                                     4 months
                                                                          
James A. Boyle   7/10/97  18,000      8.00        13.38       8.00   8 years,
MD, PhD                                                              4 months
Senior Vice      7/10/97  10,800      8.00        17.00       8.00   9 years,
President,                                                           4 months
Medical and                                                   
Regulatory                                                    
Affairs
                                                              
Ralph del Campo  7/10/97  14,000      8.00        13.38       8.00   8 years,
Vice                                                                 4 months
President,       7/10/97  10,800      8.00        17.00       8.00   9 years,
Manufacturing                                                        4 months
Operations
                                                              
Andrew S.Janoff, 7/10/97  10,400      8.00        13.38       8.00   8 years,
PhD                                                                  4 months
Vice             7/10/97   4,000      8.00        14.00       8.00   5 years,
President,                                                           4 months
Research and     7/10/97   9,200      8.00        17.00       8.00   9 years,
Development                                                          4 months
                                                          
Donald D.Yarson  7/10/97  28,800      8.00        12.00       8.00   7 years,
Vice                                                                 7 months
President        7/10/97   6,000      8.00        13.38       8.00   8 years,
Sales,                                                               4 months
Marketing,       7/10/97  15,200      8.00        17.00       8.00   9 years,
and Business                                                         4 months
Development                                                   
                                                              
(1)  Represents 80% of the number of shares subject to the listed
     options  before  the  repricing; the remaining  shares  were
     canceled.   Since  these same options are reflected  in  the
     tables  entitled  "Summary Compensation Table"  and  "Option
     Grants in 1997 Fiscal Year," this information is repetitive.

Report  of  the  Nominating and Compensation Committee  on  Stock
Option Repricing

  A stock option is the right to buy stock at a future time for a
price  fixed  when the option is awarded.  Having  stock  options
gives  an  employee a personal financial motivation to contribute
to  the  Company's success, and as the stock options become  more
valuable,  the  stockholders also experience an increase  in  the
value  of their investment so that the interests of the employees
and  the  stockholders are closely aligned.   Because  the  stock
options  awarded under the Company's plans become exercisable  in
increments  over  a  period  of  time,  they  also  serve  as  an
inducement  for the employee to stay with the Company  until  the
options become fully exercisable.

  During  1997, the disappointing results of the VENTUS(TM) clinical
trial  caused a decline in the Company's stock price to  a  level
that  was  significantly  lower than  the  exercise  price  of  a
majority  of  the  Company's  outstanding  stock  options.    The
Committee  determined that, in this instance,  the  stock  option
plans  could  no  longer  serve  the  performance  incentive  and
employee retention purposes for which they were designed.

  In  order to assure employees that they would still be rewarded
if  their efforts to bring new products to market and advance the
Company   to  profitability  were  successful,  and  to  minimize
anticipated   attrition,  on  July  10,   1997,   the   Committee
recommended,  and  the  Board  approved,  the  repricing  of  all
outstanding employee stock options having an exercise price above
$10.00  per  share.  This meant that the options  would  have  an
exercise  price  equal to the market price on  the  date  of  the
repricing, which was $8.00 per share.  In exchange for  obtaining
a  lower price, the option holders were required to surrender 20%
of  the  shares covered by their options and to wait a full  year
before  they  could  exercise any of the repriced  options.   The
repricing  was  effected either as an amendment of  the  existing
option or as the surrender of the existing option and issuance of
a  new  option, depending on the plan under which the option  was
issued.   The  repricing did not affect the term of the  options;
all repriced options expire ten years from their original date of
grant, and the normal vesting schedule will resume after the one-
year  waiting  period.   Nearly all of the options  eligible  for
repricing  were surrendered and repriced. Options  held  by  non-
employee members of the Board of Directors were not eligible  for
repricing.

James Andress
Robert F. Hendrickson
Joseph T. Stewart, Jr.
Horst Witzel, Dr.-Ing

Members of the Nominating and Compensation Committee
March 12, 1998


Report  of the Nominating and Compensation Committee on Executive
Compensation



  The  rules  of the SEC require the Nominating and  Compensation
Committee  of the Board of Directors (the "Committee") to  report
annually to the stockholders regarding the Company's compensation
policies  for the Chief Executive Officer and the other executive
officers  of  the  Company.   The  Committee's  report  regarding
compensation paid for 1997 is as follows:

Compensation Policies and Components of Compensation

  The  Company  competes in the highly technical, research-driven
biopharmaceutical  industry,  where  having  the  most  qualified
management,   technical  and  professional  personnel   is   very
important  to  success.  Although the Company  has  one  marketed
product,  ABELCET(R),  which  is the trademark  for  the  Company's
antifungal  product, amphotericin B lipid complex  injection,  it
continues  to  incur  substantial expenses  in  developing  other
products and has therefore not yet achieved profitability.   This
means that the usual financial measurements of performance,  such
as  earnings  per  share  and return on equity,  are  not  easily
applied to determine the performance of the management team.  The
lack  of profit also means that the Company is less able  to  pay
the  high  levels  of cash compensation that are  common  in  the
pharmaceutical industry.  Although we cannot offer the  same  job
security or cash compensation as a larger established company, we
are  able to attract highly motivated, entrepreneurial executives
by means of our stock options and restricted stock programs.  The
Committee  tries  to  achieve  the  right  combination  of   cash
compensation and stock-based incentives to enable it  to  attract
the  caliber  of highly educated, experienced personnel  that  it
needs  and  to reward these personnel for achieving results  that
meet or exceed investors' expectations.

Stock Options

   As   stated  above  in  the  "Report  of  the  Nominating  and
Compensation Committee on Stock Option Repricing," the  Committee
approved the repricing of options issued to all employees  having
exercise prices above $10.00 per share on July 10, 1997.  Also on
that date, the Committee reviewed plans for a restructuring to be
implemented  effective  August  1,  1997,  in  order  align   the
Company's  organization  with its new objective  of  building  an
oncology franchise.  The Committee agreed that an added incentive
would  be  useful to insure that all employees were motivated  to
put   forth   the   effort  needed  to  bring  the   Company   to
profitability.   The Committee therefore approved  the  grant  of
special   "Performance   Stock  Options"   to   employees   whose
contributions   were  considered  essential  to  achieving   this
success, which included the Chief Executive Officer and the other
Named  Executive Officers.  The exercise price of  these  options
was  $8.00 per share, which was the market price on the  date  of
grant.  One third of the options will vest on July 10, 2000,  and
the remaining two-thirds will vest on July 10, 2001.  However, if
the   Company  achieves  two  or  more  successive  quarters   of
profitability before the normal vesting dates, a portion  of  the
options  will vest early, as follows:  2 consecutive quarters  of
profitability  -  25%; 3 consecutive quarters of profitability  -
50%; 4 consecutive quarters of profitability - 100%.  The options
will  expire  if  not exercised in ten years,  and  become  fully
vested upon a change of control of the Company.

  In  connection  with the restructuring, the  Company  laid  off
approximately  105  employees, and eliminated  an  additional  32
positions,  in  order  to reduce costs.  These  measures,  though
necessary  to the Company's recovery, had the effect  of  further
demoralizing  the remaining workforce, and turnover increased  in
all areas.  At the executive level, four vice presidents left the
Company  in  1997, and no replacements were hired.  By  December,
the price of the stock had declined to just over $4.00 per share,
and  it  was clear that even the repriced options were of limited
value.   However,  rather  than  doing  another  repricing,   the
Committee  adopted an Employee Retention Program, which  included
the  grant of new stock options to all employees except executive
officers  and the establishment of a pool of restricted stock  to
be  awarded  to the executive officers.  In order  to  offer  the
opportunity  for  financial rewards over a  shorter  period  than
under  prior stock options, all option awards under the  Employee
Retention  Program were made to fully vest as of March  1,  1999.
Since  the  restricted stock awards under the Employee  Retention
Program were made in January 1998, they are not reflected in  the
1997  compensation reported for the Named Executive  Officers  in
the table entitled "Summary Compensation Table."

  In  prior years, the Committee granted options to the executive
officers and other eligible employees toward the end of each year
based  on  achievements made during the year and progress  toward
long-term  goals.  No such grant was made in 1997 except  to  Mr.
Baker,   as  described  below  under  "Chief  Executive   Officer
Compensation."  In addition, Mr. Yarson received a special  grant
of  50,000 options in late July, primarily in recognition of  his
undertaking  the  additional  responsibilities  of  international
marketing   and  corporate  development.   For  Named   Executive
Officers other than Mr. Yarson and Mr. Baker, there were no stock
options  awarded  in  1997  except in connection  with  the  July
repricing and Performance Stock Option grant.  As of December 28,
1997,  the  Company  had  outstanding grants  covering  in  total
4,352,523   shares   under  all  of  its   stock   option   plans
and  had  3,845,271 shares available for future grants under  its
two  current plans, the 1996 Equity Incentive Plan and  the  1992
Directors Nonqualified Plan.  The 1996 Equity Incentive  Plan  is
administered  by  the  Committee,  which  has  the  authority  to
determine the grantees, the exercise price, the number of  shares
subject to each option, the time or times during which all  or  a
portion of each option may be exercised, and the other provisions
of  each option.  Stock options are generally granted at the fair
market  value of the Common Stock on the date of grant, and  they
lapse  if not exercised within ten years from the date of  grant.
Options granted to employees typically vest ratably over a period
of five years, and options granted to non-employee directors vest
ratably over a five-year period in the case of the initial grant,
and over a one-year period for subsequent annual grants.

Base Salary

  In  setting the base salary levels for each executive  officer,
the   Committee   refers  to  a  survey  of   biotechnology   and
biopharmaceutical companies (the "Peer Group"), as well as  other
available information on the base salaries of executive  officers
in Peer Group companies.  The Hambrecht & Quist Healthcare Sector
Index,  which  is  used in the Performance  Graph  following  the
Committee's report, included 130 companies in 1997, more than  30
of  which are in the Peer Group survey.  Other factors considered
in  establishing  salaries include internal performance  reviews,
the  level of the executive's responsibilities and the  value  of
the  executive's  job  in the marketplace,  in  combination  with
overall compensation recommendations from management.  To  remain
competitive,  the  Company's  base  salary  ranges  and  salaries
generally  fall  within the broad mid-range of  the  Peer  Group.
Quantitative  factors,  such  as  length  of  service   and   the
Committee's   review   with   management   of   an   individual's
contribution  toward  the achievement of  the  Company's  overall
annual  strategic goals, are also taken into account in approving
specific base salaries.

Bonus Awards and Restricted Stock

  The  Company awards bonuses to certain executive officers under
annual   Management  Incentive  Plans  ("MIPs"),  which   include
performance goals approved by the Committee.  The amount of these
bonuses is determined by the Committee depending upon whether the
Company  has  met  or exceeded these goals.  The  Committee  also
retains   the   discretion  to  consider   other   criteria   and
achievements  in  determining the range  of  any  bonuses  to  be
awarded.   The  1997 MIP was approved by the Committee  in  March
1997  and provided specific corporate goals, as well as weighting
for group and individual performance.  For 1997, as reflected  in
the table entitled "Summary Compensation Table," the Company paid
year-end  bonuses  to  executive officers,  including  the  Named
Executive  Officers,  based on the Company's performance  against
its  1997  goals  and  each  individual's  contribution  to  that
performance.   The  Company's achievements for 1997,  which  were
also  considered in determining the Chairman and Chief  Executive
Officer's  bonus, included that the VENTUS(TM) Phase III  trial  had
been   completed   and  analyzed  according  to  schedule;   that
additional  European  approvals had been received  for  ABELCET(R);
that  unit  sales of ABELCET(R) had continued to grow  despite  the
introduction  of  competing products in the US  market  and  that
total revenues from ABELCET(R) had continued to grow, though  at  a
slower  rate  due  to  the price reduction made  in  response  to
competitive   pressures;  that  the  Company   had   successfully
negotiated  an alliance with Wyeth-Ayerst International  for  the
distribution  of ABELCET(R) in major European countries;  that  the
Company  had regained the rights to EVACET(TM) from Pfizer  and  had
expeditiously  assumed  responsibility for  completion  and  data
management  of the ongoing clinical trials; and that the  Company
had  protected its cash position by obtaining additional  capital
from  Ross Financial, as well as lines of credit from Pfizer  and
GE Capital.  However, the amount of the 1997 bonuses to Mr. Baker
and the other Named Executive Officers was less than in the prior
year  due  primarily to the failure to achieve revenue goals  for
ABELCET(R).   The bonuses paid to the executive officers under  the
1997 MIP, which were paid partly in cash and partly in restricted
Common  Stock,  averaged  11% of the  recipient's  year-end  base
salary.

  Awards  covering a total of 14,750 shares of restricted  Common
Stock were granted to executive officers of the Company under the
1997 MIP.  The granting of restricted stock awards was authorized
by  the  Company's 1996 Equity Incentive Plan (the "1996  Plan"),
which  was approved by the stockholders in May 1996.  The  shares
of  restricted  stock are not transferable  and  are  subject  to
forfeiture  if  the executive leaves the Company  except  due  to
retirement   or  death  before  the  restrictions   lapse.    For
restricted  stock  granted under the  1995  and  1996  MIPs,  the
restrictions lapse as to one-third of the shares granted on  each
of  the  first  three anniversaries of the date  of  grant.   For
restricted  shares granted under the 1997 MIP,  the  restrictions
lapse  as  to  one-half  of  the  shares  granted  on  the  first
anniversary of the date of grant, and as to the remainder of  the
shares on the second anniversary of the date of grant.  The owner
of  restricted shares has the right to vote these shares, and  is
entitled  to receive any distributions made to holders of  shares
of Common Stock.

  As noted above, additional restricted stock awards were made in
1998  under the Employee Retention Program, but since these  were
not based on performance goals for 1997, they are not reported in
this  Proxy  Statement as 1997 compensation.  However,  they  are
included  in the shareholdings reported as of February 25,  1998,
in the "Stock Ownership" section of this Proxy Statement.

  The  Company does not currently have specific target  ownership
levels  for  equity holding in the Company by executive  officers
and  other key employees, although increasing share ownership  by
executive  officers is an additional advantage of  stock  options
and   restricted  stock  over  some  other  forms  of   incentive
compensation.

Chief Executive Officer Compensation

  The  Committee determines Mr. Baker's salary and stock  options
based  on an annual review conducted in the last quarter of  each
year.   When Mr. Baker joined the Company in December  1989,  the
Company entered into an employment agreement with him, which  was
renewed  on June 1, 1995.  The agreement provides that Mr.  Baker
will  receive  a  designated annual base  salary,  which  may  be
increased  from time to time by the Committee.  During 1997,  Mr.
Baker's  base salary was $375,000, which represented an  increase
of  $25,000 over his base salary in effect as of the end of 1996.
This  increase  reflected  a review  of  salary  data  for  chief
executive officers of various companies in the Peer Group and was
in  recognition  of  Mr. Baker's contribution  to  the  Company's
continued  success in commercializing ABELCET(R), regaining  rights
to  EVACET(TM),  advancing the Company's other development  programs
and  maintaining its financial strength in 1997.  Based on  these
same  considerations, and to provide added potential rewards  for
increasing  stockholder  value, the Committee  also  awarded  Mr.
Baker 75,000 stock options. This was larger than his option award
in  the prior year as an acknowledgment of the key roll played by
Mr.   Baker  in  redirecting  the  Company's  efforts  after  the
announcement  of the VENTUS(TM) results, and as an added  inducement
for  him  to  remain  in  his position after  expiration  of  his
employment agreement in May 1998.

  Mr.  Baker's  employment  agreement  provides  that,  upon  the
achievement  of  certain objectives to be set  by  the  Committee
annually, he is entitled to receive a cash bonus.  For 1997,  Mr.
Baker's bonus, like the bonuses paid to other executive officers,
was determined under the 1997 MIP after the end of the year.  The
1997  objectives  were the same as those discussed  under  "Bonus
Awards  and  Restricted  Stock" above.  Based  upon  the  partial
achievement  of  these  objectives, among others,  the  Committee
awarded  Mr.  Baker a cash bonus of $40,000, which represented  a
portion of his target bonus for the 1997 fiscal year.  Mr.  Baker
did  not  receive  any  portion of his 1997 bonus  in  restricted
stock.   In addition, Mr. Baker is entitled to receive  the  same
standard benefits other Company executives receive.

  Other aspects of Mr. Baker's employment agreement are discussed
in  the  section  of  this Proxy Statement  entitled  "Employment
Agreements."

Deductibility Cap on Executive Compensation

  Section 162(m) of the Internal Revenue Code of 1986, as amended
("Section 162(m)"), disallows corporate deductibility for certain
compensation paid in excess of $1 million to the chief  executive
officer  and the four other most highly paid executive  officers.
"Performance-based compensation," as defined in the tax  law,  is
not  subject  to  the deductibility limitation, provided  certain
stockholder  approval  and  other  requirements  are  met.    The
Committee  believes  that awards designated  as  "Section  162(m)
Awards"  and  stock  options granted under  the  1996  Plan  will
qualify  for  this  exemption.  The  Committee  anticipates  that
amounts  paid  as  cash compensation will continue  to  be  fully
deductible because the amounts are expected to be less  than  the
$1 million threshold.

Summary

 In summary, the Committee believes that the option repricing and
other special measures taken in 1997 to maintain the stability of
the  Company's management team were in the best interests of  the
Company  and  its stockholders.  Through stock-based  incentives,
and cash compensation, the Committee has succeeded in maintaining
a well-qualified, highly motivated management team to provide the
continuing  leadership  needed for the  Company  to  achieve  its
future goals.

James Andress
Robert F. Hendrickson
Joseph T. Stewart, Jr.
Horst Witzel, Dr.-Ing

Members of the Nominating and Compensation Committee
March 12, 1998


Compensation Committee Interlocks and Insider Participation

No person who served on the Compensation Committee or the
Nominating and Compensating Committee during 1997 was an officer
or employee or former officer or employee of the Company, and
there were no other relationships requiring disclosure under
applicable SEC rules.


 Notwithstanding anything to the contrary set forth in any of the
Company's previous filings under the Securities Act of  1933,  as
amended, or the Securities Exchange Act of 1934, as amended, that
might incorporate future filings, including this Proxy Statement,
in  whole or in part, the following Performance Graph, the Report
of the Nominating and Compensation Committee on Option Repricing,
and  the  Report of the Nominating and Compensation Committee  on
Executive  Compensation  shall not be incorporated  by  reference
into any such filings.


Performance Graph



   The  graph  below  summarizes  the  total  cumulative  return
experienced  by  the Company's stockholders  from  1992  through
1997,  compared  to  the  Nasdaq  Total  Return  Index  of  U.S.
Companies  (the "Nasdaq U.S. Stock Index") and the  Hambrecht  &
Quist  LLC Healthcare Sector Index (the "H & Q Healthcare Sector
Index").   As  stated  in  prior proxy statements,  the  Company
believes  that  the  Nasdaq U.S. Stock Index is  an  appropriate
index  to  use  as  a  broad based comparative  measure  of  the
Company's  performance, as it incorporates the  stocks  of  many
companies  whose size and stage of development  are  similar  to
those of the Company.


                             1992   1993  1994  1995  1996  1997
The Liposome Company, Inc.    100     56    71   170   169    39
Nasdaq U.S. Stock Index       100    115   112   159   195   240
H&Q Healthcare Sector Index   100     78    78   132   136   158


Directors' Compensation

 Directors who are not employees of the Company receive an annual
retainer  of $1,000 per quarter.  In addition, during 1997,  such
directors  received  $2,000 for each Board  meeting  attended  in
person,  and $500 for each telephonic Board meeting attended.   A
director who participates in a regular Board meeting by telephone
receives  $1,000.   In  November 1997, the Company  approved  the
payment of fees for attendance at meetings of committees  of  the
Board of Directors other than those that are held on the same day
as  a  Board meeting.  For a meeting held the day before a  Board
meeting, committee members receive $500 if they attend in person,
and  for meetings held at other times (except the day of a  Board
meeting),  the  fee  is  $1,000 for attendance  in  person.   For
telephonic meetings of Board committees, and for participation by
telephone in a regular meeting, members receive a fee of $500.

 Dr. Weissmann and Dr. Samuelsson are consultants to the Company.
In  the  fiscal  year ended December 28, 1997, the  Company  paid
$47,500 in fees to Dr. Weissmann for his services as Chairman  of
the  Company's Cell Adhesion Scientific Advisory Board and Cancer
Scientific Advisory Board and for consulting services related  to
patent  litigation.  Dr. Samuelsson received $8,000 in  fees  for
his   services  as  a  member  of  the  Company's  Cell  Adhesion
Scientific Advisory Board and a $10,000 honorarium as the keynote
speaker   at   the   opening  ceremony   for   the   Indianapolis
manufacturing plant.

  The  Company believes that it is very important that it be able
to continue to attract the highest caliber of persons to serve as
non-employee  directors.   To do so, the  Company  must  be  able
adequately to compensate the directors for the responsibility and
risk they assume.  Since the Company does not offer directors the
levels  of  cash compensation they would normally receive  for  a
directorship  of  a  larger pharmaceutical  or  other  industrial
company,  stock  options offer an appropriate  way  to  partially
compensate  directors and allow them to share as stockholders  in
the  ultimate  success  of  the  Company.   The  1991  Directors'
Nonqualified Stock Option Plan (the "Directors' Plan"), which was
adopted by the stockholders in 1992, constitutes a key element of
the  Company's  long-term program to attract and compensate  non-
employee directors.

  The  Directors'  Plan provides that options to purchase  10,000
shares  of  Common Stock are automatically granted on July  1  of
each  year  from  1991 until 2001 to each non-employee  director.
These  grants  are fully vested on the first anniversary  of  the
date  of  grant.   In  addition, each new  director  receives  an
initial grant of 10,000 shares, which vests in equal installments
over a five-year period.

 As of February 25, 1998, there were eight non-employee directors
participating in the Directors' Plan.  There were eight grants of
options to acquire an aggregate of 80,000 shares of the Company's
Common Stock during fiscal year 1997 under the Directors' Plan at
an  exercise  price of $8.560 per share.  Although  the  exercise
prices  of  options  granted to directors  in  recent  years  are
significantly above the current market price, these options  were
not  included  in  the 1997 option repricing due  to  limitations
contained in the Directors' Plan.


PROPOSAL 2.  APPOINTMENT OF INDEPENDENT ACCOUNTANTS



  The  Board  of  Directors  of the Company  proposes  that  its
appointment  of  the  firm of Coopers & Lybrand  L.L.P.  as  the
Company's  independent accountants for the  fiscal  year  ending
December  27,  1998,  be ratified by the stockholders.   If  not
otherwise  specified,  proxies will be voted  in  favor  of  the
ratification of the appointment.  Representatives of  Coopers  &
Lybrand  L.L.P.  are  expected to be present  at  the  Company's
Annual Meeting with the opportunity to make a statement, if they
desire to do so, and will be available to respond to appropriate
questions.

  THE BOARD OF DIRECTORS RECOMMENDS A VOTE "FOR" RATIFICATION OF
THE APPOINTMENT OF COOPERS & LYBRAND L.L.P.


COMPLIANCE WITH SECTION 16(a) OF THE SECURITIES EXCHANGE ACT  OF
1934



  Pursuant  to Section 16(a) of the Securities Exchange  Act  of
1934,  as  amended,  directors and  executive  officers  of  the
Company  are  required to file reports with the  SEC  indicating
their  holdings  of  and transactions in  the  Company's  equity
securities.   To  the Company's knowledge,  based  solely  on  a
review  of  the copies of such reports furnished to the  Company
and written representations that no other reports were required,
during  the  fiscal  year ended December 28, 1997,  all  current
directors and executive officers filed all required reports on a
timely  basis,  except  that Mr. Feiner filed  one  late  report
regarding  the  purchase of 500 shares of Common Stock  for  his
daughter.


EXPENSE OF SOLICITATION



 The Company expects to solicit proxies by mail and by telephone,
and  it has retained Corporate Investor Communications to provide
proxy  solicitation services, at a cost of approximately  $4,000.
In  addition,  directors, officers and regular employees  of  the
Company  may  also solicit in person, by telephone  or  telegram.
All  expenses in connection with the solicitation of proxies will
be  borne  by  the Company.  Arrangements will  be  made  by  the
Company  for  the  forwarding,  at  the  Company's  expense,   of
soliciting materials by brokers, nominees, fiduciaries and 
other custodians to their principals.


STOCKHOLDER PROPOSALS



  To  be  considered for presentation to the Annual  Meeting  of
Stockholders to be held in 1999, a stockholder proposal must  be
received by Carol J. Gillespie, Vice President, General  Counsel
and  Secretary,  The Liposome Company, Inc., One  Research  Way,
Princeton  Forrestal Center, Princeton, New  Jersey  08540,  not
later than December 14, 1998.


OTHER MATTERS



 The Board of Directors knows of no other business which will be
presented  at  the  Annual Meeting. If  any  other  business  is
properly brought before the Annual Meeting, it is intended  that
proxies in the enclosed form will be voted in respect thereof in
accordance with the judgments of the persons voting the proxies.





WHETHER  OR NOT YOU INTEND TO BE PRESENT AT THE ANNUAL  MEETING,
YOUR VOTE IS IMPORTANT.  ACCORDINGLY, PLEASE COMPLETE, SIGN  AND
RETURN YOUR PROXY PROMPTLY.






THE LIPOSOME COMPANY, INC.
THIS PROXY IS SOLICITED ON BEHALF OF THE
BOARD OF DIRECTORS
Annual Meeting of Stockholders,
May 14, 1998
The Holiday Inn, 1053 Route #1,
Princeton, New Jersey 08540

P    The  undersigned  hereby appoints Charles A. Baker
     and Carol J.  Gillespie,  and
     each  of  them,  as  proxies of the undersigned,
     each with  full  power  to  act
R    without  the other and with full power of
     substitution, to vote all  the  shares
     of  Common  Stock  of  THE  LIPOSOME COMPANY, INC.
     held  in  the  name  of  the
O    undersigned at the close of business on March 27,
     1998 at the Annual Meeting  of
     Stockholders  to  be held on May 14, 1998, at 10:15
     A.M. and at any  adjournment
X    thereof,  with all the powers the undersigned would
     have if personally  present.
     The  undersigned  hereby  revokes  any and all
     proxies  heretofore  given  with
Y    respect to such meeting.







PLEASE MARK, SIGN, DATE AND RETURN THE PROXY CARD
PROMPTLY USING THE ENCLOSED
ENVELOPE.

The Board of Directors recommends a vote FOR the
following items:

1) Election of Directors

FOR all nominees listed below (except
as marked to the contrary below).

WITHHOLD AUTHORITY to vote for all
nominees listed below.

Charles A. Baker
James G. Andress
Morton Collins, Ph.D.
Stuart F. Feiner
Robert F. Hendrickson
Professor Bengt Samuelsson, M.D.
Joseph T. Stewart
Gerald Weissmann, M.D.
Horst Witzel, Dr.-Ing

To withhold authority to vote for any
individual nominee, write that name
on the line below.

_________________________________

2) Ratification of the appointment by the
   Board of Directors
   of Coopers & Lybrand L.L.P. as independent accountants for the 
   1998 fiscal year.

   FOR _______     AGAINST _______    ABSTAIN _________

3) In their discretion, upon such other
   matters as may properly
   come before the meeting, all
   in accordance
   with the
   accompanying Notice and Proxy
   Statement,
   receipt of which is
   acknowledged.

IF THIS PROXY
IS PROPERLY EXECUTED AND
RETURNED, THE
SHARES REPRESENTED THEREBY WILL
BE VOTED.  IF A
CHOICE IS SPECIFIED BY THE
STOCKHOLDER,
THE SHARES WILL BE VOTED
ACCORDINGLY.
IF NOT
OTHERWISE
SPECIFIED, THE SHARES REPRESENTED BY
THIS PROXY WILL
BE VOTED FOR THE ELECTION OF
DIRECTORS AND
FOR PROPOSAL 2.

SIGNATURE(S)_________________________________DATE________
SIGNATURE(S)______________________________DATE_________
Please sign your name exactly as it appears hereon.  In the
case of joint
owners, each should sign.  If signing in a representative
capacity, please give
title.



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