ADVANCED VIRAL RESEARCH CORP
8-K, 1998-11-23
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549




                                    FORM 8-K

     0 CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE
ACT OF 1934

        Date of report (Date of earliest event reported) November 16, 1998
                                                         -----------------

                          ADVANCED VIRAL RESEARCH CORP.
               (Exact Name of Registrant as Specified in Charter)


           Delaware                 33-2262-A                 59-2646820
 ------------------------------    ------------           -------------------
       (State or Other             (Commission              (IRS Employer
 Jurisdiction of Incorporation)    File Number)           Identification No.)


     1250 East Hallandale Beach Blvd., Suite 501, Hallandale, Florida 33009
     ----------------------------------------------------------------------
                    (Address of Principal Executive Offices)


        Registrant's telephone number, including area code (954) 458-7636
                                                           ---------------

                                       N/A
          -------------------------------------------------------------
          (Former Name or Former Address, if Changed Since Last Report)


<PAGE>


Item 7.    Financial Statements, Pro Forma Financial Information and Exhibits.

           99.1  Securities  Purchase  Agreement dated November 16, 1998, by and
           between  Advanced  Viral  Research  Corp.  and RBB Bank  AG.  Certain
           documents attached to Exhibit C (Schedule of Exceptions) are omitted.
           The Company agrees to furnish  supplementally  to the Commission upon
           request a copy of any of the omitted attachments.

           99.2     7% Convertible Debenture dated November 16, 1998.

           99.3 Warrant dated  November 16, 1998 to purchase  375,000  shares of
           common stock at $.20 per share.

           99.4 Warrant dated  November 16, 1998 to purchase  375,000  shares of
           common stock at $.24 per share.


Item 9.    Sales of Equity Securities Pursuant to Regulation S.

           On November 16, 1998 Advanced Viral Research  Corp.  (the  "Company")
for an aggregate  purchase  price of  $1,500,000  sold to RBB Bank AG ("RBB") as
agent for the accounts of certain persons, (i) a 7% Convertible Debenture in the
principal  amount of  $1,500,000  (the  "Debenture")  and (ii) two  Warrants  to
purchase shares of common stock of the Company (the "Warrants"). The sale of the
Debenture and the Warrants was made pursuant to Regulation S promulgated  by the
Securities and Exchange  Commission under the Securities Act of 1933, as amended
(the "Securities  Act"). The Company relied on the  representations,  warranties
and  covenants  of the  purchaser  made  in the  Securities  Purchase  Agreement
relating  to the  sale of the  Debenture  and  the  Warrants  for all the  facts
necessary to make the  Regulation S exemption to the  registration  requirements
under the Securities Act available.

           In connection  with the sale of the  Debenture and the Warrants,  the
Company paid RBB a placement  fee equal to 7% of the aggregate  purchase  price.
All or a portion of the Debenture  may be converted  into shares of common stock
of  the  Company  pursuant  to a  formula  more  particularly  described  in the
Debenture,  a copy of which is attached  hereto as Exhibit  99.2.  The Debenture
will mature on October 31, 2008. One of the Warrants entitles the holder thereof
to purchase in the aggregate 375,000 shares of common stock of the Company at an
exercise price of $0.20 per share. The other Warrant entitles the holder thereof
to purchase in the aggregate 375,000 shares of common stock of the Company at an
exercise  price of $0.24 per share.  Both Warrants are  exercisable  at any time
until October 31, 2008.


<PAGE>


                                   SIGNATURES


           Pursuant to the requirements of the Securities  Exchange Act of 1934,
the  registrant  has duly  caused  this report to be signed on its behalf by the
undersigned hereunto duly authorized.


                                              ADVANCED VIRAL RESEARCH CORP.
                                              ------------------------------
                                                      (Registrant)


Date:  November 20, 1998                      By: /s/ William Bregman
    -------------------------                 ------------------------------
                                              William Bregman, Secretary




EXHIBIT 99.1

                                                               November 16, 1998

         Agreement dated this 16th day of November, 1998 by and between ADVANCED
VIRAL RESEARCH CORP., a Delaware  corporation (the  "Company"),  with offices at
200  Corporate   Boulevard  South,   Yonkers,   New  York  10701  and  RBB  Bank
Aktiengesellschaft  (the "Purchaser" or "you") with offices at Burgring 16, 8010
Graz, Austria.

                                    ARTICLE I
                         AUTHORIZATION OF THE SECURITIES

         The Company represents that it has taken all corporate action necessary
to  authorize  the  issuance and sale of (a) its 7%  Convertible  Debenture  due
October 31, 2008 in the principal amount of $1,500,000 (the "Debenture") and (b)
warrants to purchase an aggregate of 750,000  shares of Common Stock,  par value
$.00001  per share  ("Common  Stock"),  of the  Company  (the  "Warrants").  The
Debenture  and the  Warrants  (collectively,  the  "Securities")  are to be sold
pursuant to this  Agreement to you.  Interest on the Debenture is payable at the
rate of 7% per annum, as more  parti8cularly  specified in the form of Debenture
attached  hereto as Exhibit A. The  Debenture is  convertible  from time to time
into shares of Common Stock as provided therein.  For purposes of this Agreement
the term "Shares" shall mean the shares of Common Stock which may be issued upon
conversion of all or a portion of the principal  amount of the Debenture and the
shares of Common  Stock  that may be issued  from time to time  pursuant  to the
exercise of the Warrants.


                                   ARTICLE II
                  SALE AND PURCHASE OF THE SECURITIES; CLOSING


         2.1.  SALE AND  PURCHASE  OF THE  SECURITIES.  Subject to the terms and
conditions  hereof  and  in  reliance  on  the  representations  and  warranties
contained  herein,  or made pursuant hereto,  the Company will issue and sell to
the Purchaser for the account of its participants (each a "Participant") as more
particularly  referred  to  below,  and the  Purchaser  will  purchase  from the
Company,  on the Closing Date  specified in Section 2.2, the  Securities for the
aggregate purchase price of $1,500,000 (the "Aggregate Purchase Price").





         2.2.  CLOSING.

               (a) The closing of the purchase and sale of the  Securities  (the
"Closing")  shall be deemed to occur when this  Agreement  has been  executed by
both the Company and the Purchaser


<PAGE>


and the Company has  received  payment for the  Securities.  Such date is herein
called the "Closing Date."

               (b) On the Closing Date there will be delivered to the  Purchaser
(i) a  Debenture  dated the  Closing  Date,  in the  principal  amount set forth
opposite the Purchaser's name on Exhibit B and (ii) warrant  certificates in the
forms of Exhibits D-1 and D-2 registered in the  Purchaser's  name  representing
the right to purchase  the number of shares of Common  Stock set forth  opposite
the Purchaser's  name on Exhibit B. The foregoing  Securities shall be delivered
by  the  Company,  against  delivery  by the  Purchaser  to  the  Company  of an
unendorsed certified or official bank check drawn upon or issued by a bank which
is a member  of the New York  Clearinghouse  for banks  (or wire  transfer)  for
$1,395,000 (the "Net Proceeds") payable to the order of the Company. The Company
agrees that the Purchaser  will retain 7% of the Aggregate  Purchase  Price as a
placement fee as more particularly described in Section 13.8.


                                   ARTICLE III
                 REPRESENTATIONS AND WARRANTIES OF THE PURCHASER

         3.1.  REGULATION S OFFERING.  The Purchaser understands and agrees with
the Company that the offer and sale of the  Securities are intended to be exempt
from the registration  requirements under the Securities Act of 1933, as amended
(the  "Securities  Act"),  by virtue of  Regulation S under the  Securities  Act
("Regulation S").

         3.2.  THE  PURCHASE  AND  THE  PURCHASER.  The Purchaser represents and
warrants to the Company that:

               (a) The Purchaser has full authority to bind each  Participant as
if such  Participant  were a party to this  Agreement  and all  representations,
warranties  and  agreements  herein  were made  directly  to the Company by such
Participant.

               (b) Each  Participant has authorized the Purchaser to make all of
the  representations  made in this Article III with respect to such  Participant
and the  Purchaser  has  verified  the accuracy  thereof  which  respect to such
Participant.

         3.3.  OFFSHORE  TRANSACTION.  The  Purchaser  represents,  warrants and
covenants to the Company that (a) no Participant  is a "U.S.  person" (the "U.S.
Person")  as that  term is  defined  in Rule  902(k)  of  Regulation  S;  (b) no
Participant is an affiliate of the Company; (c) at the time of execution of this
Agreement,  each  Participant  was  outside  the  United  States and no offer to
purchase the Securities was made in the United States;  (d) all offers and sales
of the Securities prior to the expiration of a one-year period commencing on the
Closing Date (the "Restricted  Period") shall not be made to U.S. Persons or for
the account or benefit of U.S. Persons and shall otherwise be made in compliance
with the provisions of Regulation S; (e) the  transactions  contemplated  hereby
(i) have not been and will not be pre-arranged  with a purchaser  located in the
United States or a purchaser which is a U.S.  Person,  and (ii) are not and will
not be part of a plan or scheme to evade the


<PAGE>


registration provisions of the Securities Act; (f) the Purchaser and each of the
Participants  shall  take all  reasonable  steps to ensure its  compliance  with
Regulation  S;  (g)  prior  to the  expiration  of the  Restricted  Period,  the
Purchaser  shall  promptly  send to each person buying the  Securities  from the
Purchaser,  who is a distributor,  dealer (as defined in Section 2(a)(12) of the
Securities  Exchange Act of 1934, as amended (the  "Exchange  Act")) or a person
receiving a selling  concession,  fee or other remuneration in respect of any of
the  Securities,  a  confirmation  or other  notice  stating  that such buyer is
subject to the same  restrictions  on offers and sales as a distributor  of such
Securities  pursuant to Section  903(b)(3)(iv)  of Regulation S; and (h) neither
the Purchaser nor any Participant, nor any of their affiliates or persons acting
on their behalf have  conducted any "directed  selling  efforts" as that term is
defined in Rule  902(c) of  Regulation  S; nor has the  Purchaser  or any of the
Participants,  their  affiliates or persons acting on their behalf conducted any
general  solicitation  to the  offer  and sale of any of the  Securities  in the
United States or elsewhere.

         3.4. OFFERING RESTRICTIONS. The Purchaser will, prior to the expiration
of the  Restricted  Period (a) make offers and sales of the  Securities  only in
accordance  with provisions of Rule 903 or Rule 904 of Regulation S, pursuant to
an effective  registration statement under the Securities Act; or pursuant to an
available exemption from the registration requirements under the Securities Act;
and (b) not engage in hedging transactions with regard to the Securities, unless
a hedging transaction is permissible under the Securities Act.

         3.5.  BENEFICIAL  OWNER.  Each Participant is purchasing the Securities
for its own account with respect to the  Securities.  Neither the  Purchaser nor
any Participant owns, or upon completion of this transaction, or upon conversion
of all or any  part  of the  Debenture,  and/or  exercise  of any  Warrant  will
beneficially own, more than 4.9% of the Common Stock of the Company.

         3.6.   DIRECTED  SELLING   EFFORTS.   Neither  the  Purchaser  nor  any
Participant  has engaged or will engage in any  activity  for the purpose of, or
that could reasonably be expected to have the effect of, conditioning the market
in the  United  States for any of the  Securities  sold  hereunder.  To the best
knowledge of the  Purchaser,  neither the Company nor any person  acting for the
Company has conducted any "directed  selling efforts" as that term is defined in
Rule 902 of Regulation S.

         3.7. SHORT  POSITION.  Neither the Purchaser nor any Participant or any
of their  affiliates will directly or indirectly  maintain any short position in
any securities of the Company until after the end of the Restricted Period.

         3.8.  CERTIFICATE  OF  PARTICIPANT.  Prior  to the  execution  of  this
Agreement the Purchaser has received from each  Participant a certificate in the
form attached hereto as Exhibit E, executed by such Participant.

         3.9.  INDEPENDENT  INVESTIGATION.   Each  Participant  in  electing  to
purchase the Securities  hereunder,  has relied solely upon the  representations
and  warranties of the Company set forth in this  Agreement  and on  independent
investigation made by it and its representatives, if any, and no Participant has
been given any oral or written  representations or assurance from the Company or
any


<PAGE>


representation  of the Company other than as set forth in this Agreement or in a
document  executed by a duly  authorized  representative  of the Company  making
reference to this Agreement.

         3.10.  NO  GOVERNMENT  RECOMMENDATION  OR  APPROVAL.  Each  Participant
understands that no United States federal or state agency,  or similar agency of
any other country,  has passed upon or made any recommendation or endorsement of
the Company, this transaction or the purchase of the Securities.

         3.11.  FURTHER LIMITATIONS ON DISPOSITION.  Without in any way limiting
the representations set forth above, each Participant further agrees not to make
any  disposition of all or any portion of the Securities (or the Shares issuable
upon the conversion or exercise  thereof)  unless and until (a) there is then in
effect a registration  statement under the Securities Act covering such proposed
disposition and such  disposition is made in accordance  with such  registration
statement,  (b) the  disposition is made in compliance with Regulation S; or (c)
the disposition is made pursuant to an available exemption from the registration
requirements  of the  Securities  Act and in the case of clauses (b) and (c) the
Participant  shall have  furnished  the  Company  with an  opinion  of  counsel,
reasonably  satisfactory to the Company,  that such disposition will not violate
any of the securities laws of the United States.

         3.12.  LEGAL  REPRESENTATION.  The Purchaser has the  opportunity to be
represented  in this  transaction  by  counsel of its own choice and has been so
advised by counsel for the Company.


                                   ARTICLE IV
                  REPRESENTATIONS AND WARRANTIES OF THE COMPANY

         Other than as provided in the Schedule of Exceptions attached hereto as
Exhibit C, the Company represents and warrants to you as follows:

         4.1. ORGANIZATION AND EXISTENCE, ETC. The Company is a corporation duly
organized  and  validly  existing  and in good  standing  under  the laws of its
jurisdiction  of  incorporation,  and  has all  requisite  corporate  power  and
authority  to  carry  on  its  business  as now  conducted  and  proposed  to be
conducted;  the Company has all requisite corporate power and authority to enter
into this Agreement, to issue the Securities as contemplated herein and to carry
out  and  perform  its  obligations  under  the  terms  and  conditions  of this
Agreement.  The  Company  does not own or lease  any  property  or engage in any
activity in any jurisdiction which might require qualification to do business as
a foreign  corporation in such  jurisdiction and where the failure to so qualify
would have a material  adverse effect on the financial  condition of the Company
or subject  the Company to a material  liability.  To the extent the Company has
not  qualified  to do  business  in such  jurisdictions,  it has, as of the date
hereof,  prepared the necessary  applications  or documents to be filed with the
appropriate authorities in such jurisdictions to obtain such qualifications. The
Company  has  furnished  you with  true,  correct  and  complete  copies  of its
Certificate of Incorporation, By-laws and all amendments thereto to date.


<PAGE>


         4.2.  SUBSIDIARIES AND AFFILIATES.  Except as set forth in the Schedule
of  Exceptions,  the  Company  has no  subsidiaries  and does not,  and upon the
Closing  will not,  own of record or  beneficially  any capital  stock or equity
interest or investment in any corporation, association or business entity.

         4.3.  CAPITALIZATION.

               (a) As of the date hereof, the Company's authorized capital stock
consists of  1,000,000,000  shares of Common Stock, par value $.00001 per share,
of which  296,422,907  are  outstanding,  55,800,549  of which are  reserved for
issuance  to  certain  persons  for  the  purposes  stated  in the  Schedule  of
Exceptions,  15,000,000 of which have been reserved for issuance upon conversion
of the  Debenture  and 750,000 of which have been  reserved  for  issuance  upon
exercise of the Warrants.  As of the date hereof,  the Company does not hold any
shares of its capital stock in its treasury.

               (b) All the issued and outstanding shares of capital stock of the
Company  shall,  as of the Closing,  (i) have been duly  authorized  and validly
issued,  (ii) be fully  paid and  nonassessable,  and (iii)  have been  offered,
issued,  sold and delivered by the Company in compliance with applicable federal
and state securities laws. Other than as set forth in Section 4.3(a),  there are
no outstanding preemptive, conversion or other rights, options, warrants, calls,
agreements or commitments granted or issued by or binding upon the Company,  for
the purchase or acquisition of any shares of its capital stock.

         4.4.  AUTHORIZATION. All  corporate  action  on the part of the Company
and  the  directors  and   stockholders   of  the  Company   necessary  for  the
authorization,  execution,  delivery  and  performance  by the  Company  of this
Agreement and the transactions  contemplated  herein, and for the authorization,
issuance and delivery of the Securities,  has been taken or will have been taken
prior to the Closing.

         4.5.  BINDING  OBLIGATIONS;  NO MATERIAL ADVERSE  CONTRACTS,  ETC. This
Agreement  is a valid and  binding  obligation  of the  Company  enforceable  in
accordance  with its terms.  The  execution,  delivery  and  performance  by the
Company  of this  Agreement  and  compliance  herewith  will not  result  in any
violation  of and will not  conflict  with,  or result in a breach of any of the
terms of, or constitute a default  under,  any provision of state or Federal law
to which the Company is subject,  the Certificate of Incorporation,  as amended,
or the  By-laws,  as  amended,  of the  Company,  or  any  mortgage,  indenture,
agreement,  instrument,  judgment,  decree,  order,  rule or regulation or other
restriction to which the Company is a party or by which it is bound,  or, result
in the creation of any mortgage, pledge, lien, encumbrance or charge upon any of
the properties or assets of the Company pursuant to any such term. Except as set
forth  herein no  stockholder  of the  Company  has or will have any  preemptive
rights or rights of first refusal by reason of the issuance of the Securities.

         4.6.  FINANCIAL INFORMATION. The Company has delivered to the Purchaser
true and complete  copies of the financial  information  concerning  the Company
identified in the Schedule of


<PAGE>


Exceptions.  Except  as may  be  indicated  thereon,  all  financial  statements
included in the information  given to the Purchaser fairly present the financial
position and results of operations of the Company as at their  respective  dates
and  for  their  respective   periods  in  conformity  with  generally  accepted
accounting  principles  consistently  applied  throughout  the  periods  covered
thereby.  As of  their  respective  dates  the  Company  had no  liabilities  or
obligations of any nature  (absolute,  accrued,  contingent or otherwise)  which
would  normally be reflected on a balance  sheet and which are not  reflected on
any balance sheet contained in the financial  information given to the Purchaser
or disclosed in accordance with generally accepted auditing standards.

         4.7.  COMPLIANCE WITH  INSTRUMENTS,  ETC. The Company is not in default
past any  grace,  notice  or cure  period  under  any  indenture,  agreement  or
instrument  to which it is a party or by which it is bound,  in violation of its
Certificate of Incorporation,  By-laws or of any applicable law, in default with
respect to any order,  writ,  injunction or decree of any court,  administrative
agency or  arbitrator,  or in default  under any order,  license,  regulation or
demand of any government agency, which default or violation would materially and
adversely affect the business, properties, condition (financial or otherwise) or
business prospects of the Company.

         4.8.  LITIGATION.  Except as set forth in the  Schedule of  Exceptions,
there is no action,  suit or  proceeding  pending,  or, to the  knowledge of the
Company, threatened, against the Company before any court, administrative agency
or arbitrator or any action, suit or proceeding pending, or, to the knowledge of
the Company, threatened, which challenges the validity of any action taken or to
be taken pursuant to or in connection with this Agreement or the issuance of the
Securities.

         4.9.  OFFERING.  Subject  in  part to the  truth  and  accuracy  of the
representations made by the Purchaser herein and the compliance by the Purchaser
and the Participants with its covenants set forth in this Agreement,  the offer,
sale and issuance of the  Securities as  contemplated  by this Agreement are not
subject to the registration requirements of the Securities Act, and the Company,
or anyone acting on its behalf,  will not take any action  hereafter  that would
cause such registration requirements to be applicable.

         4.10. PERMITS;  GOVERNMENTAL AND OTHER APPROVALS. The Company possesses
such franchises,  licenses, permits and other authority as are necessary for the
conduct of its business as now being  conducted  and proposed to be conducted by
the  Company  and the  Company is not in default  under any of such  franchises,
licenses,  permits or other authority.  No approval,  consent,  authorization or
other  order of, and no  designation,  filing,  registration,  qualification  or
recording  with,  any  governmental  authority  or any other person or entity is
required  in  connection  with  the  Company's  valid  execution,  delivery  and
performance of this Agreement or the offer,  issuance and sale of the Securities
by the Company to the  Purchaser or the  consummation  of any other  transaction
contemplated on the part of the Company hereby.

         4.11.  REPORTING COMPANY STATUS. The Company is a "Reporting Issuer" as
defined in Rule 902 of Regulation S. The Company has filed all material required
to be filed  pursuant to all  reporting  obligations  under Section 15(d) of the
Exchange Act, for a period of at least twelve (12) months immediately  preceding
the offer or sale of the Securities.


<PAGE>


         4.12.  OFFSHORE  TRANSACTION.  The  Company has not offered or sold the
Securities to any person in the United States,  or, to the best knowledge of the
Company,  any identifiable groups of U.S. citizens abroad, or any U.S. Person as
that  term is  defined  in  Regulation  S. At the  time  the  buy  order  of the
Securities was originated the Company and/or its agents reasonably  believed the
Purchaser was outside the United States and was not a U.S. Person.

         4.13.  PREARRANGED SALE. The Company and/or its agents believe that the
transaction  contemplated  hereby has not been  pre-arranged with a buyer in the
United States.

         4.14.  NO DIRECTED SELLING  EFFORTS.  The Company has not conducted any
"directed  selling  efforts" as that term is defined in Rule 902 of Regulation S
nor has Company  conducted  any general  solicitation  relating to the offer and
sale of the Securities to any person who is a resident  within the United States
or any other U.S. Person as that term is defined in Rule 902 of Regulation S.

         4.15.  COPYRIGHTS, TRADEMARKS AND PATENTS. Set forth in the Schedule of
Exceptions is a list of all the copyrights,  trademark registrations and patents
and applications therefor owned by the Company.

         4.16.  NO RELATIONSHIP BETWEEN PARTIES.  The Company is not an owner of
any shares of the stock of or equity  interest  in the  Purchaser.  No  officer,
director or owner of any shares of the stock of the Company or its  subsidiaries
or his close  relatives  is an officer or  director of or owns any shares of the
stock of or equity interest in the Purchaser.

         4.17.  OTHER  MATERIAL  CONTRACTS.  Set  forth  in   the   Schedule  of
Exceptions is a list of contracts  material to the  operations of the Company to
which reference is not made elsewhere in this Article IV.

         4.18.  REGISTRATION OF  TRANSFER  OF SECURITIES. The Company agrees not
to register the transfer of the Securities or Shares not made in accordance with
the  provisions of Regulation S, pursuant to  registration  under the Securities
Act or pursuant to an available exemption from registration.

         4.19.  DISCLOSURE.  The  information  heretofore  provided  and  to  be
provided  pursuant to this Agreement,  including the Schedules of Exceptions and
the Exhibits  hereto,  and each of the agreements,  documents,  certificates and
writings previously  delivered to the Purchaser or its  representatives,  do not
and will not contain any untrue statement of a material fact and do not and will
not omit to state a material  fact  required  to be stated  herein or therein or
necessary  in order to make the  statements  and writings  contained  herein and
therein not false or  misleading in the light of the  circumstances  under which
they  were  made.  To the  knowledge  of the  Company,  there  is no fact  which
materially adversely affects the business,  prospects or condition (financial or
otherwise) of the Company which has not been set forth herein.


<PAGE>


                                    ARTICLE V
                     CONDITIONS TO CLOSING OF THE PURCHASER

         The  obligation  of the  Purchaser  to purchase the  Securities  at the
Closing is subject to the  fulfillment  to the  Purchaser's  satisfaction  on or
prior to the Closing Date of each of the following conditions,  any of which may
be waived by the Purchaser:

         5.1.   REPRESENTATIONS AND WARRANTIES CORRECT.  The representations and
warranties  in  Article  IV hereof  shall be true and  correct  in all  material
respects  when made,  and shall be true and correct in all material  respects on
the Closing  Date with the same force and effect as if they had been made on and
as of the Closing Date.

         5.2.   PERFORMANCE.  All covenants, agreements and conditions contained
in this Agreement to be performed or complied with by the Company on or prior to
the Closing Date shall have been  performed  or complied  with by the Company in
all material respects.

         5.3.   NO IMPEDIMENTS. Neither the Company nor the  Purchaser  shall be
subject to any order,  decree or injunction of a court or administrative  agency
of competent  jurisdiction  which would impose any  material  limitation  on the
ability of the Purchaser to exercise full rights of ownership of the Securities.

         5.4.   OTHER AGREEMENTS. The Company shall have issued to the Purchaser
all of the Securities.

         5.5.   LEGAL INVESTMENT.  At the time  of  the Closing, the purchase of
the  Securities  to be purchased  by the  Purchaser  hereunder  shall be legally
permitted by all laws and regulations to which the Purchaser and the Company are
subject.

         5.6.   DUE  DILIGENCE  INVESTIGATION.   The Purchaser  shall  not  have
discovered  any fact,  whether or not  reflected in the Schedule of  Exceptions,
which  in the  Purchaser's  determination  would  make the  consummation  of the
transactions  contemplated  by  this  Agreement  not  in  the  Purchaser's  best
interests.

         5.7.   PROCEEDINGS  AND  OTHER  DOCUMENTS.   All  corporate  and  other
proceedings in connection with the  transactions  contemplated by this Agreement
shall  have  been  taken  and the  Purchaser  shall  have  received  such  other
documents,  in form and substance  reasonably  satisfactory to the Purchaser and
the Purchaser's  counsel,  as to such other matters  incident to the transaction
contemplated hereby as the Purchaser may reasonably request.


                                   ARTICLE VI
                      CONDITIONS TO CLOSING OF THE COMPANY


<PAGE>


         The  Company's  obligation  to sell the  Securities  at the  Closing is
subject to the  fulfillment to its  satisfaction on or prior to the Closing Date
of each of the following conditions:

         6.1.   REPRESENTATIONS.  The representations  made by the  Purchaser in
Article  III hereof  shall be true and  correct  when made and shall be true and
correct on the Closing Date.

         6.2.   LEGAL INVESTMENT.   At the time  of the Closing, the offer, sale
and  purchase  of the  Securities  shall be  legally  permitted  by all laws and
regulations to which the Purchaser and the Company are subject.

         6.3.   PAYMENT  OF  PURCHASE  PRICE.   The  Company shall have received
payment in full of the Net Proceeds.


                                   ARTICLE VII
                              OPTIONAL PREPAYMENTS

         7.1.   OPTIONAL PREPAYMENTS.  The Company may,  at its  option,  at any
time  prior to  maturity,  prepay  the  Debenture,  in whole or in part  without
premium or penalty at a price equal to the principal amount thereof plus accrued
interest thereon to the date fixed for prepayment. Any prepayments made pursuant
to this  Section  7.1 shall be applied  first to the  payment of interest on and
then to principal of the Debenture at the time outstanding.

         7.2.   NOTICE OF  PREPAYMENT.  The right of the Company  to prepay  the
Debenture pursuant to Section 7.1 shall be conditioned upon its giving notice of
prepayment,  signed  by  its  President  and by its  Treasurer  or an  Assistant
Treasurer,  to the holder of the  Debenture not less than thirty (30) days prior
to the date upon which the prepayment is to be made (the  "Prepayment  Notice"),
specifying the aggregate  principal  amount of the Debenture to be prepaid,  the
date of such  prepayment,  and the accrued and unpaid interest (to and including
the date upon which the prepayment is to be made). The Prepayment  Notice having
been so given,  the aggregate  principal amount of the Debenture so specified in
such  Prepayment  Notice,  and all accrued and unpaid  interest  thereon,  shall
become due and payable on the specified prepayment date.

         7.3.   EXERCISE  OF CONVERSION  PRIVILEGE  UPON  RECEIPT OF  PREPAYMENT
NOTICE.  Upon receipt of a Prepayment Notice, the holder of the Debenture may at
any time up to the third day preceding the  specified  prepayment  date elect to
convert all or a portion of the outstanding principal amount of the Debenture in
accordance with the terms of the Debenture.


                                  ARTICLE VIII
                              AFFIRMATIVE COVENANTS

         The Company  hereby  covenants  and agrees,  so long as any  Securities
remain outstanding, as follows:


<PAGE>


         8.1.   MAINTENANCE  OF  CORPORATE  EXISTENCE,  PROPERTIES  AND  LEASES;
TAXES; INSURANCE.

                (a) The Company  shall and shall cause each of its  subsidiaries
to,  maintain  in full  force and  effect its  corporate  existence,  rights and
franchises  and all material terms of licenses and other rights to use licenses,
trademarks,  trade names, service marks, copyrights,  patents or processes owned
or possessed by it and necessary to the conduct of its business.

                (b) The Company  shall and shall cause each of its  subsidiaries
to keep each of its properties  necessary to the conduct of its business in good
repair, working order and condition, reasonable wear and tear excepted, and from
time to time  make all  needful  and  proper  repairs,  renewals,  replacements,
additions and  improvements  thereto;  and the Company shall and shall cause its
subsidiaries  to at all times comply with each material  provision of all leases
to which it is a party or under which it occupies property.

                (c) The Company  shall and shall cause each of its  subsidiaries
to promptly pay and discharge,  or cause to be paid and discharged  when due and
payable,  all  lawful  taxes,  assessments  and  governmental  charges or levies
imposed upon the income,  profits,  assets,  property or business of the Company
and its  subsidiaries,  and  all  claims  or  indebtedness  (including,  without
limitation,  claims or  demands of  workmen,  materialmen,  vendors,  suppliers,
mechanics, carriers, warehousemen and landlords) which, if unpaid might become a
lien  upon the  assets or  property  of the  Company  or  subsidiary;  provided,
however,  that any such tax, assessment,  charge or levy need not be paid if the
validity  thereof  shall be  contested  timely and in good faith by  appropriate
proceedings,  if the  Company  or  subsidiary  shall have set aside on its books
adequate  reserves  with  respect  thereto,  and the failure to pay shall not be
prejudicial  in any  material  respect  to the  holders of the  Securities,  and
provided,  further,  that the Company or subsidiary will pay or cause to be paid
any such tax,  assessment,  charge or levy  forthwith upon the  commencement  of
proceedings to foreclose any lien which may have attached as security  therefor.
The Company  shall and shall cause its  subsidiaries  to pay or cause to be paid
all  other   indebtedness   incident  to  the   operations  of  the  Company  or
subsidiaries.

                (d) The Company  shall and shall cause each of its  subsidiaries
to keep its assets which are of an insurable  character  insured by  financially
sound and reputable  insurers against loss or damage by theft,  fire,  explosion
and other risks customarily insured against by companies in the line of business
of the Company or its subsidiaries, in amounts sufficient to prevent the Company
or its subsidiaries from becoming a co-insurer of the property insured;  and the
Company shall and shall cause its  subsidiaries  to maintain,  with  financially
sound and  reputable  insurers,  insurance  against  other hazards and risks and
liability to persons and property to the extent and in the manner  customary for
companies in similar businesses similarly situated or as may be required by law,
including,  without  limitation,  general liability,  fire and product liability
insurance  as may be required  pursuant to any  license  agreement  to which the
Company or its subsidiaries is a party or by which it is bound.

         8.2.   BASIC  FINANCIAL  INFORMATION.   The  Company  shall furnish the
following  reports to the Purchaser (or any  transferee of any  Securities),  so
long as the Purchaser is a holder of any Securities:


<PAGE>


                (a)  within  forty-five  (45) days  after the end of each of the
quarterly  accounting  periods  in  each  fiscal  year,  unaudited  consolidated
statements of income and retained earnings and cash flows of the Company and its
subsidiaries  for such quarterly period and for the period from the beginning of
such fiscal year to the end of such quarterly period, together with consolidated
balance  sheets  of the  Company  and  its  subsidiaries  as at the  end of each
quarterly  period,  setting  forth in each  case  comparisons  to  corresponding
periods in the  preceding  fiscal  year,  which  statements  will be prepared in
accordance with generally accepted accounting principles, consistently applied;

                (b) within  ninety (90) days after the end of each fiscal  year,
consolidated  statements  of income and retained  earnings and cash flows of the
Company and its  subsidiaries  for the period from the  beginning of each fiscal
year to the end of such fiscal year, and  consolidated  balance sheets as at the
end of such  fiscal  year,  setting  forth  in each  case  in  comparative  form
corresponding  figures for the preceding  fiscal year,  which statements will be
prepared  in  accordance   with  generally   accepted   accounting   principles,
consistently  applied  (except as approved by the accounting firm examining such
statements  and disclosed by the Company),  and will be  accompanied by a report
thereon of certified public accountants.

                (c) promptly as legally  permitted,  any  additional  reports or
other detailed information  concerning significant aspects of the operations and
condition, financial or otherwise, of the Company and its subsidiaries, given to
the Company by its independent accountants;

                (d) within ten (10) days after  transmission or receipt thereof,
copies of all  financial  statements,  proxy  statements  and reports  which the
Company sends to its  stockholders or directors,  and copies of all registration
statements and all regular,  special or periodic  reports which it or any of its
officers or directors files with the Commission or with any securities  exchange
on which any of the  securities of the Company are then listed or proposed to be
listed,  copies  of all  press  releases  and other  statements  made  generally
available by the Company to the public concerning  material  developments in the
business  of  the  Company   and  its   subsidiaries   and  copies  of  material
communications sent to or received from stockholders, directors or committees of
the Board of Directors of the Company or any of its  subsidiaries  and copies of
all material communications sent to and received from any lender to the Company;
and

                (e)  with  reasonable  promptness  such  other  information  and
financial  data  concerning  the  Company  as any  person  entitled  to  receive
materials under this Section 8.2 may reasonably request.

         8.3.   NOTICE OF ADVERSE CHANGE. The Company shall promptly give notice
to all holders of any Securities  (but in any event within seven (7) days) after
becoming aware of the existence of any condition or event which constitutes,  or
the occurrence of, any of the following:

                (a) any Event of Default;

                (b) the institution of an action, suit or proceeding against the
Company  before  any  court,  administrative  agency or  arbitrator,  including,
without limitation, any action of a foreign


<PAGE>


government or  instrumentality,  which, if adversely  decided,  could materially
adversely affect the business,  prospects,  properties,  financial  condition or
results of  operations  of the  Company,  whether or not arising in the ordinary
course of business; or

                (c)  any  information   relating  to  the  Company  which  could
reasonably be expected to materially and adversely affect the assets,  property,
business or condition  (financial or otherwise) of the Company or its ability to
perform the terms of this  Agreement.  Any notice  given under this  Section 8.3
shall  specify  the nature  and period of  existence  of the  condition,  event,
information,  development or  circumstance,  the anticipated  effect thereof and
what actions the Company has taken and/or proposes to take with respect thereto.

         8.4.   COMPLIANCE  WITH  AGREEMENTS; COMPLIANCE WITH LAWS.  The Company
and its subsidiaries  shall comply with the material terms and conditions of all
material  agreements,  commitments or instruments to which the Company or any of
its  subsidiaries  is a party or by which it or they may be bound.  The  Company
shall and shall cause each of its  subsidiaries  to duly comply in all  material
respects  with any  material  laws,  ordinances,  rules and  regulations  of any
foreign,  federal, state or local government or any agency thereof, or any writ,
order  or  decree,  and  conform  to  all  valid  requirements  of  governmental
authorities relating to the conduct of their respective  businesses,  properties
or assets,  including,  but not  limited  to,  the  requirements  of ERISA,  the
Environmental  Protection  Act,  the  Occupational  Safety and Health  Act,  the
Foreign  Corrupt  Practices  Act and the  rules and  regulations  of each of the
agencies administering such acts.

         8.5.   PROTECTION OF LICENSES, ETC. The Company shall maintain,  defend
and  protect to the best of its ability  licenses  and  sublicenses  (and to the
extent the Company is a licensee or sublicensee under any license or sublicense,
as permitted by the license or sublicense agreement),  trademarks,  trade names,
service  marks,   patents  and  applications   therefor  and  other  proprietary
information owned or used by it and shall keep duplicate copies of any licenses,
trademarks,  service  marks or patents  owned or used by it, if any, at a secure
place selected by the Company.

         8.6.   ACCOUNTS AND RECORDS; INSPECTIONS.

                (a) The Company  shall keep true records and books of account in
which  full,  true  and  correct  entries  will  be  made  of  all  dealings  or
transactions  in  relation  to the  business  and affairs of the Company and its
subsidiaries in accordance with generally accepted accounting principles applied
on a consistent basis.

                (b) The Company  shall  permit each holder of any  Securities or
any of such  holder's  officers,  employees or  representatives  during  regular
business  hours of the  Company,  upon  reasonable  notice  and as often as such
holder may reasonably  request,  to visit and inspect the offices and properties
of the Company and its  subsidiaries  and (i) to make  extracts or copies of the
books,  accounts  and  records of the Company or its  subsidiaries,  and (ii) to
discuss the affairs,  finances and accounts of the Company and its subsidiaries,
with the Company's (or  subsidiary's)  directors and officers,  its  independent
public accountants, consultants and attorneys.


<PAGE>


                (c) Nothing  contained in this Section 8.6 shall be construed to
limit any rights which a holder of any  Securities  (a  "Holder")  may have with
respect to the books and records of the Company and its subsidiaries, to inspect
its properties or to discuss its affairs, finances and accounts.

         8.7.   FURTHER ASSURANCES.  From time to time the Company shall execute
and deliver to the Purchaser and the Purchaser  shall execute and deliver to the
Company such other instruments,  certificates, agreements and documents and take
such other action and do all other things as may be reasonably  requested by the
other party in order to implement or effectuate the terms and provisions of this
Agreement and any of the Securities.

         8.8.   REGISTRATION RIGHTS.

                (a)  The  Company  shall  file  a  registration  statement  (the
"Registration  Statement") with the Securities and Exchange Commission,  on such
form as the Company  deems to be  appropriate,  to register the Shares under the
Securities  Act. The  Registration  Statement  shall be filed on or prior to the
60th day after the Closing Date (the "Filing  Deadline").  The Company shall use
its best efforts to cause the Registration Statement to be declared effective by
the  Securities  and Exchange  Commission  on or prior to the 90th day after the
date  the   Registration   Statement  is  filed  (the   "Effective   Deadline").
Notwithstanding any other provision contained herein, neither the failure of the
Company to file the  Registration  Statement on or prior to the Filing  Deadline
nor the  failure  of the  Company  to cause  the  Registration  Statement  to be
declared effective by the Securities and Exchange  Commission on or prior to the
Effective Deadline shall be deemed an event of default under this Agreement.

                (b) In the  event  the  Company  fails to file the  Registration
Statement  on or  prior  to the  Filing  Deadline,  the  Company  shall  pay the
Purchaser a penalty equal to the sum of (i) 2% of the Aggregate  Purchase  Price
and (ii) 0.1% of the  Aggregate  Purchase  Price for each day  lapsed  after the
Filing  Deadline,  until the  Registration  Statement is filed. In the event the
Registration  Statement is not declared effective by the Securities and Exchange
Commission on or before the Effective  Deadline,  the Company shall, in addition
to the penalty  contemplated above, pay the Purchaser a penalty equal to the sum
of (x) 2% of the Aggregate Purchase Price and (y) 0.1% of the Aggregate Purchase
Price for each day lapsed after the Effective  Deadline,  until the Registration
Statement is declared  effective  by the  Securities  and  Exchange  Commission;
provided,  however, that the total penalties under this Section 8.8(b) shall not
exceed $100,000 in the aggregate.


                                   ARTICLE IX
                               EVENTS OF DEFAULTS

         9.1.   EVENTS OF DEFAULT. If any of the following events (herein called
an "Event of Default") shall occur and be continuing:

                (a) if the Company  shall default in the payment of (i) any part
of the principal of any  Debenture,  when the same shall become due and payable,
whether at  maturity or at a date fixed for  prepayment  or by  acceleration  or
otherwise; or (ii) the interest on any Debenture; when the


<PAGE>


same shall become due and  payable,  and such default in the payment of interest
shall have continued for ten (10) days; and in each case such default shall have
continued  without  cure for ten (10) days  after  written  notice  (a  "Default
Notice") is given to the Company of such default; or

                (b) If the Company  shall default in the  performance  of any of


the covenants  contained in Article VIII and such default  shall have  continued
without  cure (i) for twenty  (20) days  after a Default  Notice is given to the
Company  with  respect to a covenant  relating to any payment of monies under an
agreement  providing  for payments of at least  $50,000 in the aggregate or (ii)
twenty (20) days after a Default  Notice is given to the Company with respect to
default in the case of a covenant  not related to the payment of monies,  by any
holder or holders of the Securities  (the Company to give forthwith to all other
holders of the Securities at the time outstanding  written notice of the receipt
of such Default Notice, specifying the default referred to therein).

                Notwithstanding the foregoing,  if any such non-monetary default
shall, by its nature, be reasonably incapable of being cured within 20 days, the
period  within which the Company shall have the right to cure such default shall
be extended for such period of time as shall enable it to cure such default upon
the exercise of due diligence.

                (c) If the Company shall default in the performance of any other
material  agreement  or covenant  contained in this  Agreement  and such default
shall not have been remedied to the  satisfaction of the holder or holders of at
least  a  majority  in  aggregate   principal  amount  of  the  Debentures  then
outstanding,  within  thirty  (30) days after a Default  Notice  shall have been
given to the Company  (the  Company to give  forthwith  to all other  holders of
Debentures and Shares at the time  outstanding  written notice of the receipt of
such Default Notice, specifying the default referred to therein); or

                Notwithstanding the foregoing,  if any such non-monetary default
shall, by its nature, be reasonably incapable of being cured within 20 days, the
period  within which the Company shall have the right to cure such default shall
be extended for such period of time as shall enable it to cure such default upon
the exercise of due diligence.

                (d) If any  representation or warranty made in this Agreement or
in or any  certificate  delivered  pursuant  hereto  shall  prove  to have  been
incorrect in any material respect when made; or

                (e) If any default  shall occur under any  indenture,  mortgage,
agreement,  instrument or  commitment  evidencing or under which there is at the
time outstanding any indebtedness of the Company (or a Material  Subsidiary,  as
hereinafter   defined),   in  excess  of  $50,000,  or  which  results  in  such
indebtedness,  in an aggregate  amount (with other  defaulted  indebtedness)  in
excess of $50,000  becoming  due and  payable  prior to its due date and if such
indenture or instrument so requires, the holder or holders thereof (or a trustee
on their behalf) shall have declared such indebtedness due and payable; or


<PAGE>


                (f) If any of the Company or its  subsidiaries  shall default in
the  observance or  performance  of any material term or provision of a material
agreement  to which it is a party or by which it is bound,  and such  default is
not waived or cured within the applicable grace period; or

                (g) If a final  judgment  which,  either alone or together  with
other  outstanding  final  judgments  against the Company and its  subsidiaries,
exceeds an  aggregate of $50,000  shall be rendered  against the Company (or any
Material  Subsidiary)  and such judgment  shall have continued  undischarged  or
unstayed for thirty (30) days after entry thereof; or

                (h) If the Company (or any  Material  Subsidiary)  shall make an
assignment for the benefit of creditors, or shall admit in writing its inability
to pay its debts; or if the Company (or any Material  Subsidiary) shall suffer a
receiver or trustee for it or  substantially  all of its assets to be appointed,
and, if appointed  without its consent,  not to be  discharged  or stayed within
ninety (90) days;  or if the Company (or any Material  Subsidiary)  shall suffer
proceedings   under  any  law  relating  to   bankruptcy,   insolvency   or  the
reorganization  or relief of debtors to be  instituted by or against it, and, if
contested by it, not to be dismissed or stayed  within  ninety (90) days;  or if
the Company (or any Material  Subsidiary) shall suffer any writ of attachment or
execution  or any  similar  process  to be issued or  levied  against  it or any
significant  part of its  property  which is not  released,  stayed,  bonded  or
vacated  within  ninety (90) days after its issue or levy; or if the Company (or
any Material  Subsidiary)  takes  corporate  action in furtherance of any of the
aforesaid purposes or conditions.

                For purposes of this Section 9.1,  "Material  Subsidiary"  means
any  subsidiary  with  respect to which the Company has  directly or  indirectly
invested, loaned, advanced or guaranteed the obligations of, an aggregate amount
exceeding  fifteen percent (15%) of the Company's gross assets, or the Company's
proportionate  share  of the  assets  or  net  income  of  which  (based  on the
subsidiary's most recent financial  statements)  exceed fifteen percent (15%) of
the Company's gross assets or net income, respectively, or the gross revenues of
which exceed  fifteen  percent (15%) of the gross  revenues of the Company based
upon the most recent financial statements of such subsidiary and the Company.

         9.2.   REMEDIES.

                (a) Upon the  occurrence  of an Event of Default,  any holder or
holders of a majority in aggregate  principal  amount of the  Debentures  at the
time  outstanding  may at any time (unless all defaults shall  theretofore  have
been  remedied)  at its or their  option,  by  written  notice or notices to the
Company (i) declare all the Debentures to be due and payable, whereupon the same
shall  forthwith  mature and  become due and  payable,  together  with  interest
accrued thereon,  without presentment,  demand,  protest or notice, all of which
are hereby waived;  and (ii) declare any other amounts  payable to the Purchaser
under this Agreement or as contemplated hereby due and payable.

                (b) Notwithstanding anything contained in Section 9.2(a), in the
event that at any time after the principal of the Debentures shall so become due
and payable and prior to the


<PAGE>


date of  maturity  stated in the  Debentures  all  arrears of  principal  of and
interest  on  the  Debentures  (with  interest  at  the  rate  specified  in the
Debentures on any overdue principal and, to the extent legally  enforceable,  on
any interest  overdue) shall be paid by or for the account of the Company,  then
the holder or holders of at least a majority in  aggregate  principal  amount of
the Debentures  then  outstanding,  by written notice or notices to the Company,
may (but  shall  not be  obligated  to)  waive  such  Event of  Default  and its
consequences  and rescind or annul such  declaration,  but no such waiver  shall
extend  to or  affect  any  subsequent  Event of  Default  or  impair  any right
resulting therefrom.  If any holder of a Debenture shall give any notice or take
any other action with respect to a claimed default, the Company,  forthwith upon
receipt of such notice or  obtaining  knowledge  of such other  action will give
written notice thereof to all other holders of the Debentures then  outstanding,
describing such notice or other action and the nature of the claimed default.

         9.3.   ENFORCEMENT. In case any  one  or  more  Events of Default shall
occur and be continuing,  the holder of a Debenture then outstanding may proceed
to protect and  enforce  the rights of such holder by an action at law,  suit in
equity or other appropriate proceeding,  whether for the specific performance of
any agreement contained herein or in such Debenture or for an injunction against
a violation of any of the terms hereof or thereof,  or in aid of the exercise of
any power  granted  hereby or thereby or by law. Each holder agrees that it will
give written notice to the other holders prior to  instituting  any such action.
In case of a default  in the  payment of any  principal  of or  interest  on any
Debenture,  the Company will pay to the holder  thereof  such further  amount as
shall be sufficient to cover the cost and the expenses of collection, including,
without limitation,  reasonable attorney's fees, expenses and disbursements.  No
course of  dealing  and no delay on the part of any holder of any  Debenture  in
exercising any rights shall operate as a waiver  thereof or otherwise  prejudice
such holder's  rights.  No right  conferred  hereby or by any Debenture upon any
holder  thereof  shall be  exclusive  of any other  right  referred to herein or
therein or now available at law in equity, by statute or otherwise.


                                    ARTICLE X
                              AMENDMENT AND WAIVER

     This  Agreement  may  not be  amended,  discharged  or  terminated  (or any
provision  hereof  waived)  without the  written  consent of the Company and the
Purchaser.  Provided that such written  consent of the Company and the Purchaser
is given:

                (a) Holders of at least a majority in aggregate principal amount
of the Debentures then outstanding may by written  instrument amend or waive any
term or condition of this  Agreement  relating to the rights or  obligations  of
holders of  Debentures,  which  amendment or waiver  operates for the benefit of
such holders, except that no such amendment or waiver shall (i) change the fixed
maturity  of any  Debenture,  the rate or the time of  mandatory  prepayment  of
principal thereof or payment of interest thereon,  the principal amount thereof,
or the terms of subordination,  if any, without the consent of the holder of the
Debenture so affected,  (ii) change the aforesaid percentage of Debentures,  the
holders  of which are  required  to  consent  to any such  amendment  or waiver,
without the consent of the holders of all the Debentures then outstanding


<PAGE>


or (iii) change the percentage of the amount of the  Debentures,  the holders of
which may declare the Debentures to be due and payable under Article IX.

                (b)  The  Company  and  each  holder  of  a  Debenture  then  or
thereafter  outstanding  shall be bound by any  amendment or waiver  effected in
accordance  with the provisions of this Article X, whether or not such Debenture
shall have been marked to indicate such  modification,  but any Debenture issued
thereafter  shall bear a notation as to any such  modification.  Promptly  after
obtaining the written consent of the holders herein provided,  the Company shall
transmit a copy of such  modification  to all of the  holders of the  Debentures
then outstanding.


                                   ARTICLE XI
                     EXCHANGE AND REPLACEMENT OF DEBENTURES

         11.1. Subject to Section 12.2, at any time at the request of any holder
of one or more of the  Debentures  to the Company at its office,  the Company at
its  expense  (except for any  transfer  tax or any other tax arising out of the
exchange) will issue in exchange  therefor new Debentures,  in such denomination
or  denominations  ($100,000  or any  larger  multiple  of  $100,000,  plus  one
Debenture in a lesser denomination,  if required) as such holder may request, in
aggregate principal amount equal to the unpaid principal amount of the Debenture
or Debentures surrendered and substantially in the form thereof, dated as of the
date to which interest has been paid on the Debenture or Debentures  surrendered
(or, if no  interest  has yet been so paid  thereon,  then dated the date of the
Debenture or Debentures so surrendered) and payable to such person or persons or
order as may be designated by such holder.

         11.2. Upon receipt of evidence satisfactory to the Company of the loss,
theft,  destruction  or mutilation of any Debenture and, in the case of any such
loss, theft, or destruction,  upon delivery of a bond of indemnity  satisfactory
to the  Company  (provided  that if the  holder is a  Purchaser  or a  financial
institution, its own agreement will be satisfactory), or in the case of any such
mutilation,  upon surrender and cancellation of such Debenture, the Company will
issue a new  Debenture  of like  tenor  as if the  lost,  stolen,  destroyed  or
mutilated  Debenture  were then  surrendered  for exchange in lieu of such lost,
stolen, destroyed or mutilated Debenture.


                                   ARTICLE XII
                      TRANSFER OF AND PAYMENT OF DEBENTURES

         12.1.  NOTIFICATION OF PROPOSED SALE.

                (a) Subject to Section  12.1(b),  each holder of a Debenture  by
acceptance  thereof  agrees that it will give the Company ten (10) days  written
notice prior to selling or otherwise  disposing of such  Debenture  during which
time the  Company  may  prepay  the  Debenture  in full.  No such  sale or other
disposition  shall be made  unless (i) the holder  shall  have  supplied  to the
Company  an  opinion of counsel  for the  holder  reasonably  acceptable  to the
Company to the effect that no registration  under the Securities Act is required
with respect to such sale or other


<PAGE>


disposition,  or (ii) an appropriate registration statement with respect to such
sale or other  disposition  shall have been filed by the  Company  and  declared
effective by the Commission.

                (b) If the  holder of  Debentures  has  obtained  an  opinion of
counsel reasonably  acceptable to the Company to the effect that the sale of its
Debentures may be made without registration under the Securities Act pursuant to
compliance  with Rule 144 (or any successor rule under the Securities  Act), the
holder need not provide the Company with the notice required in Section 12.1(a).

                (c) The  Company may endorse on all  Debentures  an  appropriate
legend restricting their transfer except upon compliance with this Section 12.1;
provided, however, that no such legend shall be endorsed on any Debenture which,
when issued,  is no longer subject to the restrictions of this Section 12.1, and
provided,  further,  that if an opinion of counsel  satisfactory  to the Company
concludes that the legend is no longer necessary,  the Company will deliver upon
transfer Debentures without such legends.

         12.2   PAYMENT.  So long as the  Purchaser  shall be the  holder of any
Debenture,  the Company  will make  payments of  principal  and  interest to the
Purchaser  no later than 11 a.m.  Eastern  Time on the date when such payment is
due.  Payments  shall be made by delivery to the  Purchaser  at the  Purchaser's
address  furnished  to the  Company  in  accordance  with  this  Agreement  of a
certified  or  official  bank  check  drawn  upon or issued by a bank which is a
member  of the New York  Clearinghouse  for  banks or by wire  transfer  to such
Purchaser's (or such Purchaser's nominee's) account at any bank or trust company
in the United States of America.  The Purchaser  further agrees that, before the
Debenture is assigned or  transferred,  the  Purchaser  will make or cause to be
made a notation thereon of principal payments previously made thereof and of the
date to which interest  thereon has been paid and will notify the Company of the
name and address of the  transferee  of such  Debenture if such name and address
are known to the Purchaser.


                                  ARTICLE XIII
                                  MISCELLANEOUS

         13.1.  GOVERNING  LAW.  This  Agreement  and the rights of the  parties
hereunder  shall be  governed  in all  respects  by the laws of the State of New
York.

         13.2.  SURVIVAL.   The   representations,   warranties,  covenants  and
agreements made herein shall survive (a) any investigation made by the Purchaser
and (b) the Closing.

         13.3.  SUCCESSORS AND ASSIGNS.  Except as otherwise  expressly provided
herein, the provisions hereof shall inure to the benefit of, and be binding upon
and enforceable by and against, the successors,  assigns,  heirs,  executors and
administrators of the parties hereto;  provided,  however,  that the Company may
not assign its rights hereunder.

         13.4.  ENTIRE AGREEMENT. This Agreement (including the Exhibits hereto)
and the other documents  delivered pursuant hereto and  simultaneously  herewith
constitute the full and entire


<PAGE>


understanding  and  agreement  between  the  parties  with regard to the subject
matter hereof and thereof.

         13.5.  NOTICES, ETC. All notices, demands or other communications given
hereunder  shall be in  writing  and shall be  sufficiently  given if  delivered
either personally or by a nationally  recognized courier service marked for next
business day delivery or sent in a sealed envelope by first class mail,  postage
prepaid and either registered or certified, addressed as follows:

                (a)    if to the Company:

                       Advanced Viral Research Corp.
                       200 Corporate Boulevard South
                       Yonkers, New York  10701
                       Attention:       Shalom Z. Hirschman, M.D.
                                        President and Chief Executive Officer

                (b)    if to the Purchaser,  to the address set forth on the
                       first page of this Agreement.

or to such other address with respect to any party hereto as such party may from
time to time  notify (as  provided  above) the other  parties  hereto.  Any such
notice,  demand or  communication  shall be deemed to have been given (i) on the
date of delivery, if delivered personally,  (ii) one business day after delivery
to a nationally  recognized  overnight  courier service,  if marked for next day
delivery or (iii) five business days after the date of mailing, if mailed.

                Copies  of any  notice,  demand  or  communication  given to the
Company, shall be delivered to Wolf, Block, Schorr and Solis-Cohen LLP, 250 Park
Avenue, New York, New York, 10177, Attn.: Robert E. Fischer, Esq., or such other
address as may be directed.

         13.6.  DELAYS OR OMISSIONS. No delay or omission to exercise any right,
power or remedy  accruing  to any  holder of any  Securities  upon any breach or
default of the Company under this Agreement  shall impair any such right,  power
or remedy of such  holder nor shall it be  construed  to be a waiver of any such
breach or default,  or an acquiescence,  therein, or of or in any similar breach
or default  thereafter  occurring;  nor shall any waiver of any single breach or
default  be deemed a waiver  of any  other  breach  or  default  theretofore  or
thereafter  occurring.  Any waiver,  permit,  consent or approval of any kind or
character  on the  part of any  holder  of any  breach  or  default  under  this
Agreement,  or any  waiver  on the  part  of any  holder  of any  provisions  or
conditions  of this  Agreement  must be, made in writing and shall be  effective
only to the extent specifically set forth in such writing. All remedies,  either
under this  Agreement  or by law or otherwise  afforded to any holder,  shall be
cumulative and not alternative.

         13.7.  RIGHTS;  SEVERABILITY.   Unless  otherwise  expressly   provided
herein, each Purchaser's rights hereunder are several rights, not rights jointly
held with any other  person.  In case any provision of this  Agreement  shall be
invalid, illegal or unenforceable,  the validity, legality and enforceability of
the remaining provisions shall not in any way be affected or impaired thereby.


<PAGE>


         13.8.  PLACEMENT FEE.

                (a) In  connection  with the  consummation  of the  transactions
contemplated  herein,  the Company  will pay RBB Bank  Aktiengesellschaft  a fee
equal to 7% of the Aggregate Purchase Price, which fee will be deducted from the
Aggregate Purchase Price to be paid to the Company at the Closing Date.

                (b) Except the fee  described  in Section  13.8(a),  the Company
hereby (i) represents and warrants that the Company has not retained a finder or
broker in connection  with the  transactions  contemplated by this Agreement and
(ii)  agrees to  indemnify  and to hold the  Purchaser  harmless of and from any
liability for commission or  compensation in the nature of an agent's fee to any
broker,  person or firm,  and the costs and expenses of  defending  against such
liability  or asserted  liability,  including,  without  limitation,  reasonable
attorney's  fees,  arising  from any act by the Company or any of the  Company's
employees or representatives;  provided, however, that the Company will have the
right to defend against such liability by representative(s) of its own choosing,
and provided,  further, that the Company will not settle or compromise any claim
or  lawsuit  without  prior  written  notice to the  Purchaser  of the terms and
provisions  thereof.  In the event that the Company  shall fail to undertake the
defense  within ten (10) days of any notice of such claim,  the Purchaser  shall
have the right to undertake the defense,  compromise or settlement of such claim
upon written notice to the Company by holders of a majority in principal  amount
of the  Debentures  and the Company  will be  responsible  for and shall pay all
costs and expenses of defending  such  liability or asserted  liability  and any
amounts paid in settlement.

                (c)  The  Purchaser  (i)  represents  and  warrants  that it has
retained no finder or broker in connection with the transactions contemplated by
this  Agreement  and (ii) hereby  severally  agrees to indemnify and to hold the
Company  harmless from any liability for any commission or  compensation  in the
nature of an agent's or finder's  fee to any broker or other person or firm (and
the costs,  including  reasonable legal fees, and expenses of defending  against
such liability or asserted  liability) for which such  Purchaser,  or any of its
employees or representatives, are responsible.

         13.9.  EXPENSES.  Each of the parties  shall bear its own  expenses and
legal fees incurred on its behalf with respect to the negotiation, execution and
consummation of the transactions contemplated by this Agreement.

         13.10. LITIGATION.  The parties  each hereby waive trial by jury in any
action or  proceeding  of any kind or nature in any court in which an action may
be  commenced  arising out of this  Agreement or by reason of any other cause or
dispute  whatsoever  between them.  The parties  hereto agree that the State and
Federal  Courts  which sit in the  State of New York and the  County of New York
shall have exclusive  jurisdiction  to hear and determine any claims or disputes
between the Company and such holders,  pertaining directly or indirectly to this
Agreement or to any matter arising therefrom.  The parties each expressly submit
and  consent  in  advance  to such  jurisdiction  in any  action  or  proceeding
commenced in such courts provided that such consent shall


<PAGE>


not be deemed to be a waiver of personal  service of the summons and  complaint,
or other process or papers issued therein. The choice of forum set forth in this
Section  13.10 shall not be deemed to preclude the  enforcement  of any judgment
obtained  in such  forum or the taking of any action  under  this  Agreement  to
enforce  same in any  appropriate  jurisdiction.  The  parties  each  waive  any
objection  based upon forum non  conveniens  and any  objection  to venue of any
action instituted hereunder.

         13.11. TITLES AND SUBTITLES.  The titles of the articles,  sections and
subsections of this Agreement are for  convenience of reference only and are not
to be considered in construing this Agreement.

         13.12. COUNTERPARTS.  This  Agreement may  be executed in any number of
counterparts,  each of which  shall be an  original,  but all of which  together
shall constitute one instrument.

         If the Purchaser is in agreement with the foregoing the Purchaser shall
sign where  indicated  below and  thereupon  this letter  shall become a binding
agreement between the Purchaser and the Company.


                                Very truly yours,

                                ADVANCED VIRAL RESEARCH CORP.

                                By:   \s\ Shalom Hirschman
                                   ---------------------------------------------
                                Name:      Shalom Z. Hirschman, M.D.
                                Title:     President and Chief Executive Officer


AGREED:

RBB BANK AKTIENGESELLSCHAFT                     (as agent for its clients  whose
                                                names can not be  disclosed  due
                                                to Austrian bancsecrecylaws. RBB
By: \s\ Herbert Strauss                         Bank  does  not  buy  any of the
Name: Herbert Strauss                           debenture   itself  and  has  no
Title:                                          voting   power   or   power   of
                                                disposition  over the securities
                                                owned by the clients)


<PAGE>


                                    EXHIBIT A

           THIS DEBENTURE AND THE SHARES OF COMMON STOCK ISSUABLE UPON
               THE CONVERSION OF THIS DEBENTURE (COLLECTIVELY, THE
         "SECURITIES") HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT
       OF 1933, AS AMENDED (THE "SECURITIES ACT"), AND MAY NOT BE OFFERED
         OR SOLD IN THE UNITED STATES OR TO U.S. PERSONS (AS DEFINED IN
           REGULATION S UNDER THE SECURITIES ACT) UNLESS IN ACCORDANCE
            WITH REGULATION S, PURSUANT TO AN EFFECTIVE REGISTRATION
            STATEMENT, OR PURSUANT TO AN AVAILABLE EXEMPTION FROM THE
        REGISTRATION REQUIREMENTS UNDER THE SECURITIES ACT. IN ADDITION,
            HEDGING TRANSACTIONS INVOLVING THE SECURITIES MAY NOT BE
             CONDUCTED UNLESS IN COMPLIANCE WITH THE SECURITIES ACT.

              FORM OF 7% CONVERTIBLE DEBENTURE DUE OCTOBER 31, 2008


$1,500,000                                                     November   , 1998
                                                              New York, New York

          FOR  VALUE  RECEIVED,   ADVANCED  VIRAL  RESEARCH  CORP.,  a  Delaware
corporation (the "undersigned" or the "Company"),  hereby promises to pay to the
order of                 , at its offices located at                       or at
such other place as the holder  hereof  shall  designate to the  undersigned  in
writing, in lawful money of the United States of America or in New York Clearing
House Funds, the principal amount of One Million Five Hundred Thousand  Dollars,
and to pay  interest  (computed  on the basis of a 360-day  year and the  actual
number of days  elapsed) on the unpaid  principal  amount  hereof at the rate of
seven (7%) percent per annum. The undersigned promises to pay the said principal
sum and interest as follows:

          Until this Debenture is completely  retired the undersigned shall make
payments of accrued  interest on this  Debenture on the first day of January and
July in each year (commencing with January 1, 1999),  computed at the rate of 7%
per annum on the unpaid principal  balance of this Debenture for the period from
the date of this Debenture until the date of such interest  payment.  On October
31, 2008 the undersigned  shall pay the holder all unpaid principal and interest
on this Debenture.

          Interest on the indebtedness evidenced by this Debenture after default
or maturity accelerated or otherwise shall be due and payable at the rate of ten
(10%) percent per annum, subject to the limitations of applicable law.

          If this Debenture or any installment hereof becomes due and payable on
a Saturday,  Sunday or public  holiday  under the laws of the State of New York,
the due date hereof  shall be extended to the next  succeeding  business day and
interest shall be payable at the rate of seven (7%)


<PAGE>


percent per annum during such  extension.  All  payments  received by the holder
shall be applied first to the payment of all accrued interest payable hereunder.

          Subject to and in compliance  with the provisions  hereof,  the holder
shall have the right to convert  all or a portion of the  outstanding  principal
amount of this Debenture  into such number of shares of Common Stock,  par value
$.00001 per share, of the Company  ("Common  Stock") (the shares of Common Stock
issuable upon  conversion of this Debenture are  hereinafter  referred to as the
"Conversion  Shares") as shall equal the  quotient  obtained by dividing (x) the
principal  amount  of this  Debenture  to be  converted  by (y)  the  Applicable
Conversion  Price (as  hereinafter  defined) and by surrender of this Debenture,
such surrender to be made in the manner provided herein; provided, however, that
the right to convert outstanding  principal of this Debenture shall terminate at
the close of business on the third  calendar  day  preceding  the date fixed for
prepayment unless the Company shall default in making such prepayment.

          For purposes hereof the term "Applicable  Conversion Price" shall mean
the lesser of (q) $0.20 and (r) the  product  obtained  by  multiplying  (i) the
Average Closing Price (as hereinafter defined) by (iii) .72.

          For purposes  hereof the "Average  Closing  Price" with respect to any
conversion  elected to be made by the holder  shall be the  average of the daily
closing  prices for the three  consecutive  trading  days,  as  selected  by the
holder, out of the ten trading days immediately  preceding the date on which the
holder gives the Company a written  notice of the  holder's  election to convert
outstanding  principal of this  Debenture.  The closing price on any trading day
shall be (a) if the  Common  Stock is then  listed or quoted on either  the NASD
Bulletin Board,  the NASDAQ SmallCap Market or the NASDAQ National  Market,  the
reported closing bid price for the Common Stock on such day or (b) if the Common
Stock is  listed  on  either  the  American  Stock  Exchange  or New York  Stock
Exchange, the last reported sales price for the Common Stock on such exchange on
such day.

          On the date notice is delivered  in order to exercise  its  conversion
right,  the holder shall  surrender this Debenture to the Company at its office,
accompanied  by written  notice to the Company that the holder  hereof elects to
convert  all  or a  specified  portion  of the  outstanding  principal  of  this
Debenture (the "Conversion Notice"). Within five (5) business days after receipt
of this Debenture and the Conversion  Notice, the Company will pay to the holder
all interest  accrued on the principal  amount of this Debenture to be converted
to the effective date of conversion or, at the sole option of the Company, issue
to the holder in lieu thereof such  additional  number of shares of Common Stock
as shall equal the  quotient  obtained by dividing  the total  amount of accrued
interest  on the  principal  amount of this  Debenture  to be  converted  by the
Applicable  Conversion Price.  Within five (5) business days after the surrender
of this Debenture,  as aforesaid,  the Company shall cause its transfer agent to
issue and deliver to such holder,  or on its written  order,  a  certificate  or
certificates  without any restrictive legend thereon for the number of shares of
Common  Stock  issuable  upon  the  conversion  hereof  in  accordance  with the
provisions of this Debenture,  and any fractional interest in respect of a share
of Common Stock  arising upon such  conversion  shall be settled as  hereinafter
provided.  If the  Company  fails to  deliver  to the  holder a  certificate  or
certificates for shares of Common Stock as aforesaid prior to the expiration


<PAGE>


of five (5) business days after receipt of the  Conversion  Notice and surrender
to the Company of the Debenture,  the Company shall pay to the holder a penalty.
The penalty shall be $1,000 if the certificate or certificates are not delivered
until the sixth business day after the delivery of the Conversion Notice and the
penalty shall double every business day until the  certificate  or  certificates
are so  delivered,  but in no event  shall such  penalty  exceed  $100,000.  For
example,  if the  certificates  are  delivered on the eighth  business day after
delivery of the  Conversion  Notice and  surrender of the  Debenture the penalty
shall be $4,000.

          If the entire  outstanding  principal  amount of this Debenture is not
converted,  the  Company  shall  also  issue and  deliver  to such  holder a new
Debenture of like tenor in the principal amount equal to the principal which was
not converted and dated the effective date of conversion.  Each conversion shall
be deemed to have been  effected  immediately  prior to the close of business on
the date on which this  Debenture  shall have been  surrendered  and such notice
received by the Company as aforesaid, and the person or persons in whose name or
names any  certificate  of  certificates  for  shares of Common  Stock  shall be
issuable  upon such  conversion  shall be deemed to have  become  the  holder or
holders of record of the shares  represented  thereby at such time on such date.
All shares of Common Stock  delivered upon  conversion of this  Debenture  will,
upon  delivery,   be  duly  authorized,   validly  issued  and  fully  paid  and
nonassessable.  No  fractional  shares of  Common  Stock  shall be  issued  upon
conversion of this  Debenture.  Instead of any fractional  share of Common Stock
which would otherwise be deliverable  upon the conversion of a principal of this
Debenture the Company shall pay to the holder an amount in cash (computed to the
nearest cent) equal to the Average Closing Price multiplied by the fraction of a
share of Common Stock represented by such fractional interest.

          The  issuance  of  certificates  for  shares of Common  Stock upon any
conversion of this  Debenture  shall be made without  charge to the payee hereof
for any tax or other  expense in respect to the  issuance of such  certificates,
all of  which  taxes  and  expenses  shall  be paid  by the  Company,  and  such
certificates  shall be issued only in the name of the registered  holder of this
Debenture.

          This Debenture has been issued pursuant to and shall be subject to all
of the  provisions  of the  Purchase  Agreement.  The payee is  entitled  to the
benefits  of the  Purchase  Agreement,  and this  Debenture  may be  prepaid  as
provided in the Purchase Agreement. Reference is made to Sections 7.2 and 7.3 of
the Purchase  Agreement  with respect to certain rights of the holder to convert
this Debenture into Common Stock upon receipt of a notice of prepayment.

          Upon  the  occurrence  of any  one or more of the  events  of  default
specified or referred to in the Purchase  Agreement or in the other documents or
instruments executed in connection therewith,  all amounts then remaining unpaid
on this Debenture may be declared to be immediately  due and payable as provided
in the Purchase Agreement.

          In the event  that this  Debenture  shall be placed in the hands of an
attorney  for  collection  by  reason  of any event of  default  hereunder,  the
undersigned agrees to pay reasonable


<PAGE>


attorney's fees and disbursements and other reasonable  expenses incurred by the
payee in connection with the collection of this Debenture.

          The  rights,  powers  and  remedies  given  to the  payee  under  this
Debenture shall be in addition to all rights, powers and remedies given to it by
virtue of the  Purchase  Agreement,  any  document  or  instrument  executed  in
connection therewith, or any statute or rule of law.

          Any  forbearance,  failure  or delay by the  payee in  exercising  any
right,  power or remedy  under  this  Debenture,  the  Purchase  Agreement,  any
documents or instruments executed in connection therewith or otherwise available
to the payee shall not be deemed to be a waiver of such right,  power or remedy,
nor shall any single or partial exercise of any right,  power or remedy preclude
the further exercise thereof.

          No  modification  or waiver of any  provision of this  Debenture,  the
Purchase  Agreement  or any  documents  or  instruments  executed in  connection
therewith  shall be  effective  unless it shall be in writing  and signed by the
payee,  and any such  modification  or waiver  shall apply only in the  specific
instance for which given.

          This Debenture and the rights and  obligations of the parties  hereto,
shall be governed,  construed and interpreted according to the laws of the State
of New York, and the undersigned  consents and agrees that the State and Federal
Courts  which  sit in the  State of New  York,  County  of New York  shall  have
exclusive jurisdiction of all controversies and disputes arising hereunder.

          The term  "payee" as used herein  shall be deemed to include the payee
and its successors, endorsees and assigns.

          The  undersigned  hereby  waives  presentment,   demand  for  payment,
protest, notice of protest and notice of non-payment hereof.


                                        By: 
                                            ------------------------------------
                                            Shalom Z. Hirschman, M.D., President
                                            and Chief Executive Officer


<PAGE>


<TABLE>
<CAPTION>
                                    EXHIBIT B




Name and Address of Purchaser              Security Purchased                    Purchase Price
- -----------------------------              ------------------                    --------------

<S>                                 <C>                                           <C>
                                    $1,500,000 principal amount of 7%
                                    Convertible Debenture due October
                                    31, 2008                                      $
                                                                                   ------------
                                    Warrant to purchase 375,000 shares
                                    of Common Stock, par value $.00001

                                    per share in the form of Exhibit D-1          $
                                                                                   ------------

                                    Warrant to purchase 375,000 shares
                                    of Common Stock, par value $.00001
                                    per share in the form of Exhibit D-2          $
                                                                                   ------------
</TABLE>


<PAGE>


                                    EXHIBIT C
                                       TO
                          SECURITIES PURCHASE AGREEMENT
                             DATED NOVEMBER 16, 1998
                      BETWEEN ADVANCED VIRAL RESEARCH CORP.
                                 AND RBB BANK AG


                             Schedule of Exceptions


SUBSIDIARY

Exception 4.2    The Company caused to be  incorporated  in the  Commonwealth of
                 the Bahamas,  Grand Bahama,  Freeport,  a corporation under the
                 name Advance Viral Research  Limited.  One thousand  shares are
                 issued,  of which 996 are held by Bernard Friedland and William
                 Bregman  under a  Declaration  of Trust for the  benefit of the
                 Company.  The  remaining  four  shares  are held by a  domestic
                 nominee.  The Company has been  advised by local  counsel  that
                 this is the normal manner to reduce costs and foreign corporate
                 entanglements  for a  United  State  company  to  organize  and
                 maintain  a  subsidiary  in  that  jurisdiction.  A copy of the
                 Declaration  of Trust,  dated November 16, 1987, is attached to
                 this item.

OPTIONS

Exception 4.3    There  is  attached  hereto a  schedule  listing  the  names of
                 optionees,  together with the respective option prices,  number
                 of options,  aggregate cost and expiration date of the options.
                 In each case the options were created for services  rendered or
                 to be rendered.


LITIGATION AND PROCEEDINGS

Exception 4.8    A.  During  1988 and 1989,  the U.S.  Securities  and  Exchange
                 Commission  ("SEC")  conducted an informal inquiry into certain
                 of the  Company's  prior  disclosure  documents,  including its
                 original  prospectus,  press  releases and annual  reports.  On
                 December  14,  1989,  the  SEC,  as  plaintiff,  filed  a civil
                 complaint for permanent  injunction and other equitable  relief
                 (the "Complaint") in the United States District Court, Southern
                 District of Florida,  Miami Division,  against the Company, its
                 President,  Bernard  Friedland,  and  its  Secretary-Treasurer,
                 William Bregman.  The Complaint alleged  violations of Sections
                 5(b)(2) and 17(a) of the  Securities  Act of 1933,  as amended,
                 Sections  10(b) and  15(d) of the  Securities  Exchange  Act of
                 1934,  as amended,  and Rules 10b-5,  12b-20,  15d-1 and 15d-13
                 adopted thereunder.


<PAGE>


                 The  Company,  Bernard  Friedland  and  William  Bregman  each,
                 without  admitting or denying the allegations of the Complaint,
                 consented to the entry of an injunction. A permanent injunction
                 was entered, which required the Company, in accordance with its
                 undertaking,  to  make  a  rescission  offer  described  by the
                 Company in previous disclosure. There is attached hereto a copy
                 of  the  Final  Judgment  of  Permanent  Injunction  and  Other
                 Equitable Relief.

                 B. The  Company  has been  made a party  to  litigation  in the
                 Superior  Court  of the  State  of  California,  County  of Los
                 Angeles,  West  District,  initiated  by Susan L.  Liebman,  as
                 plaintiff,  against  Donaldson,  Lufkin &  Jenrette  Securities
                 Corporation  and a number of other  defendants,  including  the
                 Company. The Company retained Saltzburg, Ray & Bergman, LLP, as
                 counsel  to  represent  its  interests.  Counsel  has  moved to
                 dismiss  the   proceeding   on   jurisdictional   grounds  (see
                 Attachment  to this  item) to quash the  service  of summon for
                 lack of personal  jurisdiction and the motion has been granted.
                 As such, the Company is no longer a party to the litigation.

PERMITS

Exception 4.10   The  Company  does not  currently  possess  approvals  from the
                 United States Food and Drug Administration or similar authority
                 of any foreign  jurisdiction to test or to market its products,
                 except  that the  Company  now has the  permission  to test its
                 products in Mexico and Argentina. Applications will be filed in
                 other  appropriate  jurisdictions  as  promptly  as the Company
                 deems practical.

INTANGIBLE RIGHTS

Exception 4.15   There is attached  hereto a copy of a letter dated  November 4,
                 1998 from Cohen, Pontani, Lieberman & Pavane, patent counsel to
                 the Company,  addressed to Robert E. Fischer  captioned "Status
                 Report of U.S.  Patent  Position of Advanced  Viral  Research".
                 This  document  sets  forth the  current  status of all  patent
                 applications  filed,  prepared and in  preparation on behalf of
                 the Company.

                 There  further  is  attached  hereto a copy of a  letter  dated
                 February  12,  1997 from patent  counsel to the Company  making
                 reference to trademark "Reticulose".  This letter refers to the
                 status of the  registration of that Mark as of the date of this
                 letter.

OTHER MATERIAL CONTRACTS

Exception 4.17   Set forth below are the  contracts  or  excerpts  of  contracts
                 deemed by the Company to be material but not otherwise referred
                 to in this schedule of exceptions.

                 A.  Amended  and  Restated  Employment  Agreement  of Shalom Z.
                 Hirschman.  Exhibit 99.1 to the Form 8-K filed on July 20, 1998
                 by the Company with the


<PAGE>


                 Securities and Exchange  Commission is  incorporated  herein by
                 reference  for  the  terms  of  the  Agreement.  

                 B. Lease for  executive  office and research  space in Yonkers,
                 New  York   executed  by  the  Company  on  February  4,  1997.
                 References shall be made to Securities and Exchange  Commission
                 filings of the Company for terms of the Lease.

                 C. Summary of  Distribution  Agreements  by the Company and the
                 following named distributees for the territories indicated.

                   1. Advanced Viral Research Corporation (Party A), Beijing
                      Unistone Pharmaceutical Co., Ltd. (Party B) and AVIX
                      International Pharmaceutical Corporation (Party C) - China
                   2. Advanced Viral Research Corp. and DCT S.R.L. - Argentina,
                      Bolivia, Paraguay, Uruguay, Brazil and Chile
                   3. Advanced Viral Research Corp. and Dormer Laboratories Inc.
                      - Canada
                   4. Advanced Viral Research Corporation and Commonwealth
                      Pharmaceuticals of the Channel Islands - Channel Islands, 
                      Isle of Man, British West Indies, Jamaica, Haiti, Bermuda
                      and Belize
                   5. Advanced Viral Research Corporation and Commonwealth
                      Pharmaceuticals - Saudi Arabia

                 Copies of the  foregoing  agreements  referred to in Subparts B
and C will be provided upon request.

REFERENCES BY INCORPORATION.

All disclosures made in reports, schedules, forms and other documents, which the
Company has filed with the  Securities and Exchange  Commission  pursuant to the
Securities Act of 1933, as amended,  and the securities Exchange Act of 1934, as
amended,  to the extent that such disclosures are pertinent to the provisions of
Article IV of the Agreement, are hereby incorporated by reference.


<PAGE>


                                   EXHIBIT D-1

          THIS WARRANT AND THE SHARES OF COMMON STOCK ISSUABLE UPON THE
         EXERCISE OF THIS WARRANT (COLLECTIVELY, THE "SECURITIES") HAVE
        NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED
          (THE "SECURITIES ACT"), AND MAY NOT BE OFFERED OR SOLD IN THE
       UNITED STATES OR TO U.S. PERSONS (AS DEFINED IN REGULATION S UNDER
           THE SECURITIES ACT) UNLESS IN ACCORDANCE WITH REGULATION S,
         PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT, OR PURSUANT TO
            AN AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS
           UNDER THE SECURITIES ACT. IN ADDITION, HEDGING TRANSACTIONS
             INVOLVING THE SECURITIES MAY NOT BE CONDUCTED UNLESS IN
                       COMPLIANCE WITH THE SECURITIES ACT.


                               WARRANT TO PURCHASE

                    COMMON STOCK, PAR VALUE $.00001 PER SHARE

                                       OF

                          ADVANCED VIRAL RESEARCH CORP.
                          -----------------------------



         This certifies that, for value received,                           , or
registered  assigns  ("Warrantholder"),  is entitled to purchase  from  ADVANCED
VIRAL RESEARCH CORP. (the "Company"), subject to the provisions of this Warrant,
at any time and from time to time  until  5:00  p.m.  Eastern  Standard  Time on
October 31,  2008,  375,000  shares of the  Company's  Common  Stock,  par value
$.00001 per share  ("Warrant  Shares").  The  purchase  price  payable  upon the
exercise of this Warrant shall be $0.20 per Warrant Share. The Warrant Price and
the number of Warrant Shares which the  Warrantholder is entitled to purchase is
subject to  adjustment  upon the  occurrence of the  contingencies  set forth in
Section 3 of this  Warrant,  and as adjusted  from time to time,  such  purchase
price is hereinafter referred to as the "Warrant Price."

         This Warrant is subject to the following terms and conditions:

    I    EXERCISE OF WARRANT.

         (a) This  Warrant  may be  exercised  in whole or in part but not for a
fractional share. Upon delivery of this Warrant at the offices of the Company or
at such other  address as the Company may  designate by notice in writing to the
registered  holder  hereof  with  the  Subscription  Form  annexed  hereto  duly
executed,  accompanied by payment of the Warrant Price for the number of Warrant
Shares purchased (in cash, by certified,  cashier's or other check acceptable to
the Company, by Common Stock of the Company having a Market


<PAGE>


Value (as  hereinafter  defined)  equal to the  aggregate  Warrant Price for the
Warrant  Shares to be  purchased,  or any  combination  of the  foregoing),  the
registered  holder of this Warrant shall be entitled to receive a certificate or
certificates   for  the  Warrant  Shares  so  purchased.   Such  certificate  or
certificates shall be promptly delivered to the Warrantholder.  Upon any partial
exercise of this Warrant, the Company shall execute and deliver a new Warrant of
like tenor for the balance of the Warrant Shares purchasable hereunder.

         (b) In lieu of exercising  this Warrant  pursuant to Section 1(a),  the
holder may elect to receive  shares of Common  Stock  equal to the value of this
Warrant  determined  in the  manner  described  below  (or any  portion  thereof
remaining  unexercised)  upon  delivery  of this  Warrant at the  offices of the
Company  or at such other  address as the  Company  may  designate  by notice in
writing to the  registered  holder  hereof with the Notice of Cashless  Exercise
Form annexed hereto duly executed.  In such event the Company shall issue to the
holder a number of shares  of the  Company's  Common  Stock  computed  using the
following formula:

                                   X = Y (A-B)
                                       -------
                                        A

Where    X = the number of shares of Common Stock to be issued to the holder.
         Y = the number of shares of Common Stock purchasable under this Warrant
             (at the date of such calculation).
         A = the Market Value of the Company's  Common Stock on the business day
             immediately  preceding  the day on which  the  Notice  of  Cashless
             Exercise is received by the Company.
         B = Warrant Price (as adjusted to the date of such calculation).

         (c) The Warrant Shares deliverable  hereunder shall, upon issuance,  be
fully paid and  non-assessable  and the Company  agrees that at all times during
the term of this Warrant it shall cause to be reserved for issuance  such number
of shares of its Common  Stock as shall be required  for  issuance  and delivery
upon exercise of this Warrant.

         (d) For purposes of this Warrant, the Market Value of a share of Common
Stock on any date  shall be equal to (i) the  closing  sale  price  per share as
published by a national  securities exchange on which shares of Common Stock (or
other  units of the  security)  are traded (an  "Exchange")  on such date or, if
there is no sale of Common Stock on such date,  the average of the bid and asked
prices on such  exchange at the close of trading on such date or, (ii) if shares
of Common Stock are not listed on a national  securities  exchange on such date,
the  closing  price  per  share as  published  on the  National  Association  of
Securities Dealers Automatic  Quotation System ("NASDAQ") National Market System
if the shares are quoted on such  system on such date,  or (iii) the  average of
the bid and asked prices in the over-the-counter  market at the close of trading
on such date if the shares are not traded on an exchange or listed on the NASDAQ
National Market System,  or (iv) if the Common Stock is not traded on a national
securities exchange or in the over-the-counter  market, the fair market value of
a share of Common Stock on such date as determined in good faith by the Board of
Directors. If the holder disagrees with the determination of the Market Value of
any securities of the Company determined by the Board of Directors under Section
1(d)(iv) the Market Value of such securities shall be determined by an


                                        2

<PAGE>


independent  appraiser  acceptable  to the  Company  and the holder (or, if they
cannot agree on such an appraiser,  by an independent appraiser selected by each
of them,  and Market  Value shall be the median of the  appraisals  made by such
appraisers).  If there is one  appraiser,  the  cost of the  appraisal  shall be
shared equally between the Company and the holder.  If there are two appraisers,
each of the Company and the holder shall pay for its own appraisal.

    II   TRANSFER OR ASSIGNMENT OF WARRANT.

         (a) Any  assignment  or  transfer  of  this  Warrant  shall  be made by
surrender of this Warrant at the offices of the Company or at such other address
as the Company may designate in writing to the registered holder hereof with the
Assignment  Form annexed hereto duly executed and  accompanied by payment of any
requisite  transfer taxes,  and the Company shall,  without charge,  execute and
deliver a new Warrant of like tenor in the name of the  assignee for the portion
so  assigned  in case of only a partial  assignment,  with a new Warrant of like
tenor to the assignor for the balance of the Warrant Shares purchasable.

         (b) Prior to any  assignment  or transfer of this  Warrant,  the holder
thereof  shall  deliver an opinion of counsel to the  Company to the effect that
the proposed transfer may be effected without registration under the Act.

    III   ADJUSTMENT  OF WARRANT  PRICE  AND  WARRANT  SHARES  --  ANTI-DILUTION
          PROVISIONS.

               A. (1) Except as hereinafter  provided, in case the Company shall
          at any time after the date  hereof  issue any  shares of Common  Stock
          (including   shares   held   in  the   Company's   treasury)   without
          consideration,  then, and thereafter  successively upon each issuance,
          the Warrant  Price in effect  immediately  prior to each such issuance
          shall  forthwith be reduced to a price  determined by multiplying  the
          Warrant  Price  in  effect  immediately  prior to such  issuance  by a
          fraction:

                    (a)  the  numerator  of which  shall be the total  number of
                         shares of Common Stock outstanding immediately prior to
                         such issuance, and

                    (b)  the  denominator  of which shall be the total number of
                         shares of Common Stock  outstanding  immediately  after
                         such issuance.

     For the  purposes  of any  computation  to be made in  accordance  with the
provisions of this clause (1), the following provisions shall be applicable:

                        (i)   Shares of Common Stock issuable by way of dividend
                              or other  distribution on any stock of the Company
                              shall be  deemed  to have  been  issued  and to be
                              outstanding at the close of business on the record
                              date fixed for the  determination  of stockholders
                              entitled  to  receive   such   dividend  or  other
                              distribution and shall be


                                        3

<PAGE>


                              deemed to have been issued without  consideration.
                              Shares of Common Stock issued  otherwise than as a
                              dividend,  shall be deemed to have been issued and
                              to be  outstanding at the close of business on the
                              date of issue.

                        (ii)  The  number of shares of Common  Stock at any time
                              outstanding  shall not  include  any  shares  then
                              owned  or  held  by or  for  the  account  of  the
                              Company.

                  (2) In case the Company shall at any time subdivide or combine
            the  outstanding  shares of Common  Stock,  the Warrant  Price shall
            forthwith   be   proportionately   decreased  in  the  case  of  the
            subdivision or proportionately  increased in the case of combination
            to the nearest one cent. Any such adjustment  shall become effective
            at the  close of  business  on the date  that  such  subdivision  or
            combination shall become effective.

               B. In the event that the number of  outstanding  shares of Common
          Stock is  increased  by a stock  dividend  payable in shares of Common
          Stock or by a subdivision of the  outstanding  shares of Common Stock,
          which may include a stock split, then from and after the time at which
          the adjusted Warrant Price becomes effective pursuant to the foregoing
          Subsection  A  of  this   Section  by  reason  of  such   dividend  or
          subdivision,  the number of shares  issuable upon the exercise of this
          Warrant   shall  be  increased  in  proportion  to  such  increase  in
          outstanding shares. In the event that the number of outstanding shares
          of Common  Stock is  decreased  by a  combination  of the  outstanding
          shares of  Common  Stock,  then,  from and after the time at which the
          adjusted Warrant Price becomes effective pursuant to such Subsection A
          of this  Section by reason of such  combination,  the number of shares
          issuable  upon the  exercise of this  Warrant  shall be  decreased  in
          proportion to such decrease in outstanding shares.

               C.   In  the  event  of  an  adjustment of the Warrant Price, the
          number of shares of Common Stock (or reclassified stock) issuable upon
          exercise of this Warrant after such  adjustment  shall be equal to the
          number determined by dividing:

                    (1)  an amount  equal to the  product  of (i) the  number of
                         shares of Common Stock  issuable  upon exercise of this
                         Warrant immediately prior to such adjustment,  and (ii)
                         the Warrant Price immediately prior to such adjustment,
                         by

                    (2)  the Warrant Price immediately after such adjustment.


                                        4

<PAGE>


               D.  In the case of any reorganization or reclassification  of the
          outstanding  shares of Common Stock (other than a change in par value,
          or from par value to no par value,  or from no par value to par value,
          or as a result of a subdivision or  combination) or in the case of any
          consolidation  of the Company  with,  or merger of the  Company  with,
          another  corporation,  or in the case of any sale, lease or conveyance
          of all, or substantially  all, of the property,  assets,  business and
          goodwill of the Company as an entity, the holder of this Warrant shall
          thereafter  have the right  upon  exercise  to  purchase  the kind and
          amount of shares of stock and other securities and property receivable
          upon such reorganization,  reclassification,  consolidation, merger or
          sale by a holder of the  number of  shares of Common  Stock  which the
          holder of this  Warrant  would have  received  had all Warrant  Shares
          issuable upon exercise of this Warrant been issued  immediately  prior
          to such  reorganization,  reclassification,  consolidation,  merger or
          sale, at a price equal to the Warrant Price then in effect  pertaining
          to this  Warrant  (the kind,  amount and price of such stock and other
          securities to be subject to adjustment as herein provided).

               E. In case the Company shall, at any time prior to the expiration
          of this Warrant and prior to the exercise thereof, dissolve, liquidate
          or wind up its affairs, the Warrantholder shall be entitled,  upon the
          exercise  thereof,  to receive,  in lieu of the Warrant  Shares of the
          Company  which it would have been  entitled to receive,  the same kind
          and amount of assets as would have been issued, distributed or paid to
          it upon such Warrant Shares of the Company,  had it been the holder of
          record of shares of Common Stock  receivable upon the exercise of this
          Warrant on the record date for the  determination of those entitled to
          receive any such liquidating distribution. After any such dissolution,
          liquidation  or winding up which shall result in any  distribution  in
          excess  of the  Warrant  Price  provided  for  by  this  Warrant,  the
          Warrantholder  may at its  option  exercise  the same  without  making
          payment of the  aggregate  Warrant  Price and in such case the Company
          shall upon the  distribution to said  Warrantholder  consider that the
          aggregate  Warrant  Price  has been  paid in full to it and in  making
          settlement to said Warrantholder, shall deduct from the amount payable
          to such Warrantholder an amount equal to the aggregate Warrant Price.

               F. In case the Company shall, at any time prior to the expiration
          of this Warrant and prior to the exercise  thereof make a distribution
          of assets  (other  than  cash) or  securities  of the  Company  to its
          stockholders (the "Distribution") the Warrantholder shall be entitled,
          upon the  exercise  thereof,  to  receive,  in addition to the Warrant
          Shares it is entitled  to receive,  the same kind and amount of assets
          or securities as would have been distributed to it in the Distribution
          had it been the holder of record of shares of Common Stock  receivable
          upon exercise of this Warrant on the record date for  determination of
          those entitled to receive the Distribution.


                                        5

<PAGE>


               G.  Irrespective  of any  adjustments  in the  number of  Warrant
          Shares  and  the  Warrant  Price  or the  number  or  kind  of  shares
          purchasable  upon exercise of this Warrant,  this Warrant may continue
          to express the same price and number and kind of shares as  originally
          issued.

     IV  OFFICER'S  CERTIFICATE. Whenever  the number of Warrant  Shares and the
Warrant Price shall be adjusted pursuant to the provisions  hereof,  the Company
shall forthwith file, at its principal  executive office a statement,  signed by
the  Chairman  of the Board,  President,  or one of the Vice  Presidents  of the
Company and by its Chief Financial Officer or one of its Treasurers or Assistant
Treasurers,  stating the adjusted  number of Warrant  Shares and the new Warrant
Price  calculated  to the nearest one  hundredth and setting forth in reasonable
detail the method of calculation  and the facts  requiring  such  adjustment and
upon which such  calculation is based.  Each  adjustment  shall remain in effect
until a subsequent  adjustment  hereunder is required.  A copy of such statement
shall be mailed to the Warrantholder.

     V   CHARGES, TAXES AND EXPENSES.  The issuance of certificates  for Warrant
Shares upon any  exercise of this Warrant  shall be made  without  charge to the
Warrantholder  for any tax or other  expense in respect to the  issuance of such
certificates,  all of which taxes and expenses shall be paid by the Company, and
such certificates shall be issued only in the name of the Warrantholder.

     VI  MISCELLANEOUS.

         (a) The terms of this Warrant  shall be binding upon and shall inure to
the  benefit of any  successors  or assigns of the  Company and of the holder or
holders  hereof and of the shares of Common  Stock  issued or issuable  upon the
exercise hereof.

         (b) No holder of this  Warrant,  as such,  shall be entitled to vote or
receive  dividends  or be  deemed to be a  stockholder  of the  Company  for any
purpose,  nor shall  anything  contained  in this Warrant be construed to confer
upon the holder of this Warrant,  as such,  any rights of a  stockholder  of the
Company or any right to vote, give or withhold consent to any corporate  action,
receive  notice of  meetings,  receive  dividends  or  subscription  rights,  or
otherwise.

         (c)  Receipt  of this  Warrant by the holder  hereof  shall  constitute
acceptance of an agreement to the foregoing terms and conditions.

         (d) The Warrant and the  performance of the parties  hereunder shall be
construed and  interpreted in accordance  with the laws of the State of New York
and the parties  hereunder  consent and agree that the State and Federal  Courts
which  sit in the  State of New  York and the  County  of New  York  shall  have
exclusive  jurisdiction  with respect to all  controversies and disputes arising
hereunder.


                                        6

<PAGE>


         (e) Shares  issued  upon  exercise  of this  Warrant  shall be legended
substantially as follows:

         "The  shares  evidenced  by this  certificate  have  not  been
         registered  under the Securities Act of 1933, as amended,  and
         must be held indefinitely unless they are transferred pursuant
         to an effective registration statement under that Act or after
         receipt of an opinion of counsel  satisfactory  to the Company
         that registration is not required."

         IN WITNESS WHEREOF, the Company has caused this Warrant to be signed by
its duly authorized officer and its corporate seal to be affixed hereto.

Dated: November _____, 1998

                                             ADVANCED VIRAL RESEARCH CORP.



                                             BY:
                                                --------------------------------
                                                   Shalom Hirschman, M.D.
                                                   President


                                        7

<PAGE>


                                SUBSCRIPTION FORM


                    (TO BE EXECUTED BY THE REGISTERED HOLDER
                     IF HE DESIRES TO EXERCISE THE WARRANT)


         To:      ADVANCED VIRAL RESEARCH CORP.


                  The  undersigned   hereby  exercises  the  right  to  purchase
_________  shares of Common Stock,  par value $.00001 per share,  covered by the
attached  Warrant  in  accordance  with the terms and  conditions  thereof,  and
herewith makes payment of the Warrant Price for such shares in full.


                                    -------------------------------------------
                                    SIGNATURE


                                    --------------------------------------------
                                    ADDRESS

                                    --------------------------------------------



DATED:
      --------------------


<PAGE>


                   NOTICE OF EXERCISE OF COMMON STOCK WARRANT
             PURSUANT TO NET ISSUE ("CASHLESS") EXERCISE PROVISIONS


                                                                        , 199   
                                                            ------------     ---


Advanced Viral Research Corp.        Aggregate Price of          $
a Delaware corporation               of Warrant                   --------------
200 Corporate Boulevard South
Yonkers, New York 10701              Aggregate Price Being
                                     Exercised:                  $
Attention:                                                        --------------
          --------------------       Warrant Price
                                     (per share):                $
                                     Number of Shares of          --------------
                                     Common Stock to be
                                     Issued Under this
                                     Notice:



                                CASHLESS EXERCISE


Gentlemen:

                  The undersigned,  registered holder of the Warrant to Purchase
Common Stock delivered herewith  ("Warrant")  hereby irrevocably  exercises such
Warrant for, and  purchases  thereunder,  shares of the Common Stock of ADVANCED
VIRAL RESEARCH CORP., a Delaware  corporation,  as provided  below.  Capitalized
terms used herein,  unless  otherwise  defined  herein,  shall have the meanings
given in the  Warrant.  The  portion  of the  Aggregate  Price  (as  hereinafter
defined)  to be applied  toward the  purchase of Common  Stock  pursuant to this
Notice of Exercise is $ , thereby  leaving a remainder  Aggregate Price (if any)
equal to $
        . Such exercise shall be pursuant to the net issue  exercise  provisions
of Section 1(b) of the Warrant; therefore, the holder makes no payment with this
Notice of Exercise.  The number of shares to be issued pursuant to this exercise
shall be  determined  by reference to the formula in Section 1(b) of the Warrant
which  requires  the use of the Market  Value (as defined in Section 1(d) of the
Warrant) of the Company's Common Stock on the business day immediately preceding
the day on which  this  Notice is  received  by the  Company.  To the extent the
foregoing exercise is for less than the full Aggregate Price of the Warrant, the
remainder of the Warrant  representing  a number of Shares equal to the quotient
obtained by dividing the remainder of the  Aggregate  Price by the Warrant Price
(and otherwise of like form, tenor and effect) may be exercised under Section


<PAGE>


1(a) of the  Warrant.  For  purposes of this Notice the term  "Aggregate  Price"
means the product  obtained by multiplying  the number of shares of Common Stock
for which the Warrant is exercisable times the Warrant Price.


                                    -------------------------------------------
                                    SIGNATURE

DATE:
     --------------------           --------------------------------------------
                                    ADDRESS


                                        2

<PAGE>


                                   ASSIGNMENT


                    (To be Executed by the Registered Holder
                     if he Desires to Transfer the Warrant)


                  FOR VALUE RECEIVED,  the undersigned hereby sells, assigns and
transfers  unto                          the right to purchase  shares of Common
Stock of ADVANCED VIRAL RESEARCH  CORP.,  evidenced by the within  Warrant,  and
does hereby irrevocably constitute and appoint                          Attorney
to transfer  the said  Warrant on the books of the  Company,  with full power of
substitution.


                                    -------------------------------------------
                                    SIGNATURE


                                    --------------------------------------------
                                    ADDRESS

DATED:
      ---------------------

IN THE PRESENCE OF:


- ---------------------------


<PAGE>


                                   EXHIBIT D-2


          THIS WARRANT AND THE SHARES OF COMMON STOCK ISSUABLE UPON THE
         EXERCISE OF THIS WARRANT (COLLECTIVELY, THE "SECURITIES") HAVE
        NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED
          (THE "SECURITIES ACT"), AND MAY NOT BE OFFERED OR SOLD IN THE
       UNITED STATES OR TO U.S. PERSONS (AS DEFINED IN REGULATION S UNDER
           THE SECURITIES ACT) UNLESS IN ACCORDANCE WITH REGULATION S,
         PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT, OR PURSUANT TO
            AN AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS
           UNDER THE SECURITIES ACT. IN ADDITION, HEDGING TRANSACTIONS
             INVOLVING THE SECURITIES MAY NOT BE CONDUCTED UNLESS IN
                       COMPLIANCE WITH THE SECURITIES ACT.


                               WARRANT TO PURCHASE

                    COMMON STOCK, PAR VALUE $.00001 PER SHARE

                                       OF

                          ADVANCED VIRAL RESEARCH CORP.

     -----------------------------------------------------------------------



                  This certifies that, for value received,                     ,
                                                           --------------------
or registered assigns  ("Warrantholder"),  is entitled to purchase from ADVANCED
VIRAL RESEARCH CORP. (the "Company"), subject to the provisions of this Warrant,
at any time and from time to time  until  5:00  p.m.  Eastern  Standard  Time on
October 31,  2008,  375,000  shares of the  Company's  Common  Stock,  par value
$.00001 per share  ("Warrant  Shares").  The  purchase  price  payable  upon the
exercise of this Warrant shall be $0.24 per Warrant Share. The Warrant Price and
the number of Warrant Shares which the  Warrantholder is entitled to purchase is
subject to  adjustment  upon the  occurrence of the  contingencies  set forth in
Section 3 of this  Warrant,  and as adjusted  from time to time,  such  purchase
price is hereinafter referred to as the "Warrant Price."

                  This Warrant is subject to the following terms and conditions:

          1.   EXERCISE OF WARRANT.
               (1)  This Warrant may be exercised in  whole or  in  part but not
for a  fractional  share.  Upon  delivery of this  Warrant at the offices of the
Company  or at such other  address as the  Company  may  designate  by notice in
writing to the  registered  holder  hereof with the  Subscription  Form  annexed
hereto duly executed, accompanied by payment of the Warrant Price for the number
of Warrant Shares purchased (in cash, by certified, cashier's or other check


<PAGE>


acceptable to the Company,  by Common Stock of the Company having a Market Value
(as  hereinafter  defined) equal to the aggregate  Warrant Price for the Warrant
Shares to be purchased,  or any  combination of the  foregoing),  the registered
holder  of  this  Warrant  shall  be  entitled  to  receive  a  certificate   or
certificates   for  the  Warrant  Shares  so  purchased.   Such  certificate  or
certificates shall be promptly delivered to the Warrantholder.  Upon any partial
exercise of this Warrant, the Company shall execute and deliver a new Warrant of
like tenor for the balance of the Warrant Shares purchasable hereunder.

               (2)  In lieu of exercising this Warrant pursuant to Section 1(a),
the  holder may elect to receive  shares of Common  Stock  equal to the value of
this Warrant  determined in the manner  described  below (or any portion thereof
remaining  unexercised)  upon  delivery  of this  Warrant at the  offices of the
Company  or at such other  address as the  Company  may  designate  by notice in
writing to the  registered  holder  hereof with the Notice of Cashless  Exercise
Form annexed hereto duly executed.  In such event the Company shall issue to the
holder a number of shares  of the  Company's  Common  Stock  computed  using the
following formula:

                                   X = Y (A-B)
                                       -------
                                        A

Where    X = the number of shares of Common Stock to be issued to the holder.
         Y = the number of shares of Common Stock purchasable under this Warrant
             (at the date of such calculation).
         A = the Market Value of the Company's  Common Stock on the business day
             immediately  preceding  the day on which  the  Notice  of  Cashless
             Exercise is received by the Company.
         B = Warrant Price (as adjusted to the date of such calculation).


               (3)  The  Warrant  Shares   deliverable   hereunder  shall,  upon
issuance,  be fully paid and  non-assessable  and the Company agrees that at all
times during the term of this Warrant it shall cause to be reserved for issuance
such number of shares of its Common  Stock as shall be required for issuance and
delivery upon exercise of this Warrant.

               (4)  For purposes of this Warrant, the Market Value of a share of
Common  Stock on any date shall be equal to (i) the closing sale price per share
as published by a national  securities  exchange on which shares of Common Stock
(or other units of the security) are traded (an  "Exchange") on such date or, if
there is no sale of Common Stock on such date,  the average of the bid and asked
prices on such  exchange at the close of trading on such date or, (ii) if shares
of Common Stock are not listed on a national  securities  exchange on such date,
the  closing  price  per  share as  published  on the  National  Association  of
Securities Dealers Automatic  Quotation System ("NASDAQ") National Market System
if the shares are quoted on such  system on such date,  or (iii) the  average of
the bid and asked prices in the over-the-counter  market at the close of trading
on such date if the shares are not traded on an exchange or listed on the NASDAQ
National Market System,  or (iv) if the Common Stock is not traded on a national
securities exchange or in the over-the-counter  market, the fair market value of
a share of Common Stock on such date as determined in good faith by the Board of
Directors. If the holder disagrees with the determination of the Market Value of
any securities of the Company determined by the Board of


                                        2

<PAGE>


Directors under Section  1(d)(iv) the Market Value of such  securities  shall be
determined by an independent  appraiser acceptable to the Company and the holder
(or, if they cannot  agree on such an  appraiser,  by an  independent  appraiser
selected by each of them, and Market Value shall be the median of the appraisals
made by such appraisers).  If there is one appraiser,  the cost of the appraisal
shall be shared  equally  between the  Company and the holder.  If there are two
appraisers, each of the Company and the holder shall pay for its own appraisal.

          2.   TRANSFER OR ASSIGNMENT OF WARRANT.

               (1)  Any  assignment or transfer of this Warrant shall be made by
surrender of this Warrant at the offices of the Company or at such other address
as the Company may designate in writing to the registered holder hereof with the
Assignment  Form annexed hereto duly executed and  accompanied by payment of any
requisite  transfer taxes,  and the Company shall,  without charge,  execute and
deliver a new Warrant of like tenor in the name of the  assignee for the portion
so  assigned  in case of only a partial  assignment,  with a new Warrant of like
tenor to the assignor for the balance of the Warrant Shares purchasable.

               (2)   Prior to  any  assignment  or transfer of this Warrant, the
holder  thereof shall deliver an opinion of counsel to the Company to the effect
that the proposed transfer may be effected without registration under the Act.

          3.   ADJUSTMENT OF WARRANT PRICE AND WARRANT  SHARES --  ANTI-DILUTION
               PROVISIONS.

                    A. (1) Except as hereinafter  provided,  in case the Company
               shall at any time  after  the date  hereof  issue  any  shares of
               Common Stock  (including  shares held in the Company's  treasury)
               without  consideration,  then, and thereafter  successively  upon
               each issuance,  the Warrant Price in effect  immediately prior to
               each  such  issuance  shall  forthwith  be  reduced  to  a  price
               determined by multiplying the Warrant Price in effect immediately
               prior to such issuance by a fraction:

                    (a)  the  numerator  of which  shall be the total  number of
                         shares of Common Stock outstanding immediately prior to
                         such issuance,  and 

                    (b)  the  denominator  of which shall be the total number of
                         shares of Common Stock  outstanding  immediately  after
                         such issuance.

     For the  purposes  of any  computation  to be made in  accordance  with the
provisions of this clause (1), the following provisions shall be applicable:

                              (i)       Shares of Common  Stock  issuable by way
                                        of dividend or other distribution on any
                                        stock of the Company  shall be deemed to
                                        have been  issued and to be  outstanding
                                        at the close of  business  on the record
                                        date  fixed  for  the  determination  of
                                        stockholders entitled to receive


                                        3

<PAGE>


                                        such dividend or other  distribution and
                                        shall  be  deemed  to have  been  issued
                                        without consideration.  Shares of Common
                                        Stock   issued   otherwise   than  as  a
                                        dividend,  shall be  deemed to have been
                                        issued  and  to be  outstanding  at  the
                                        close of business on the date of issue.

                              (ii)      The number of shares of Common  Stock at
                                        any time  outstanding  shall not include
                                        any shares  then owned or held by or for
                                        the account of the Company.

                        (2) In case  the  Company  shall at any  time  subdivide
               or combine the  outstanding  shares of Common Stock,  the Warrant
               Price shall forthwith be proportionately decreased in the case of
               the  subdivision  or  proportionately  increased  in the  case of
               combination  to the nearest one cent. Any such  adjustment  shall
               become  effective  at the close of business on the date that such
               subdivision or combination shall become effective.

                    B. In the event  that the  number of  outstanding  shares of
               Common Stock is increased by a stock  dividend  payable in shares
               of Common Stock or by a subdivision of the outstanding  shares of
               Common  Stock,  which may  include a stock  split,  then from and
               after  the time at  which  the  adjusted  Warrant  Price  becomes
               effective pursuant to the foregoing  Subsection A of this Section
               by reason of such dividend or  subdivision,  the number of shares
               issuable  upon the exercise of this Warrant shall be increased in
               proportion to such increase in outstanding  shares.  In the event
               that  the  number  of  outstanding  shares  of  Common  Stock  is
               decreased by a combination  of the  outstanding  shares of Common
               Stock,  then,  from and  after  the time at  which  the  adjusted
               Warrant Price becomes effective  pursuant to such Subsection A of
               this Section by reason of such combination,  the number of shares
               issuable  upon the exercise of this Warrant shall be decreased in
               proportion to such decrease in outstanding shares.

                    C. In the event of an adjustment of the Warrant  Price,  the
               number of shares of Common Stock (or reclassified stock) issuable
               upon  exercise of this  Warrant  after such  adjustment  shall be
               equal to the number determined by dividing:

                    (1)  an amount  equal to the  product  of (i) the  number of
                         shares of Common Stock  issuable  upon exercise of this
                         Warrant immediately prior to such adjustment,  and (ii)
                         the Warrant Price immediately prior to such adjustment,
                         by

                    (2)  the Warrant Price immediately after such adjustment.


                                        4

<PAGE>


                    D. In the case of any reorganization or  reclassification of
               the  outstanding  shares of Common  Stock (other than a change in
               par  value,  or from par  value to no par  value,  or from no par
               value  to  par  value,  or  as  a  result  of  a  subdivision  or
               combination) or in the case of any  consolidation  of the Company
               with, or merger of the Company with, another  corporation,  or in
               the  case  of  any  sale,   lease  or   conveyance   of  all,  or
               substantially all, of the property, assets, business and goodwill
               of the  Company as an entity,  the holder of this  Warrant  shall
               thereafter  have the right upon exercise to purchase the kind and
               amount  of shares of stock  and  other  securities  and  property
               receivable    upon   such    reorganization,    reclassification,
               consolidation, merger or sale by a holder of the number of shares
               of Common  Stock  which the  holder of this  Warrant  would  have
               received had all Warrant  Shares  issuable  upon exercise of this
               Warrant  been issued  immediately  prior to such  reorganization,
               reclassification, consolidation, merger or sale, at a price equal
               to the Warrant  Price then in effect  pertaining  to this Warrant
               (the kind, amount and price of such stock and other securities to
               be subject to adjustment as herein provided).

                    E. In case  the  Company  shall,  at any  time  prior to the
               expiration  of this  Warrant and prior to the  exercise  thereof,
               dissolve,  liquidate  or wind up its affairs,  the  Warrantholder
               shall be entitled, upon the exercise thereof, to receive, in lieu
               of the  Warrant  Shares of the  Company  which it would have been
               entitled to receive,  the same kind and amount of assets as would
               have been  issued,  distributed  or paid to it upon such  Warrant
               Shares of the Company, had it been the holder of record of shares
               of Common Stock  receivable  upon the exercise of this Warrant on
               the  record  date  for the  determination  of those  entitled  to
               receive  any  such  liquidating  distribution.   After  any  such
               dissolution,  liquidation or winding up which shall result in any
               distribution  in excess of the Warrant Price provided for by this
               Warrant,  the  Warrantholder  may at its option exercise the same
               without making payment of the aggregate Warrant Price and in such
               case  the   Company   shall   upon  the   distribution   to  said
               Warrantholder  consider that the aggregate Warrant Price has been
               paid   in  full  to  it  and  in   making   settlement   to  said
               Warrantholder,  shall  deduct  from the  amount  payable  to such
               Warrantholder an amount equal to the aggregate Warrant Price.

                    F. In case  the  Company  shall,  at any  time  prior to the
               expiration of this Warrant and prior to the exercise thereof make
               a  distribution  of assets (other than cash) or securities of the
               Company   to   its   stockholders   (the    "Distribution")   the
               Warrantholder  shall be entitled,  upon the exercise thereof,  to
               receive,  in  addition  to the  Warrant  Shares it is entitled to
               receive,  the same kind and  amount of  assets or  securities  as
               would have been distributed to it in the Distribution had it been
               the holder of record of shares of Common  Stock  receivable  upon
               exercise of this Warrant on the record date for  determination of
               those entitled to receive the Distribution.



                                        5

<PAGE>


                    G.  Irrespective of any adjustments in the number of Warrant
               Shares  and the  Warrant  Price or the  number  or kind of shares
               purchasable  upon  exercise  of this  Warrant,  this  Warrant may
               continue  to express the same price and number and kind of shares
               as originally issued.

          4.   OFFICER'S  CERTIFICATE. Whenever the number of Warrant Shares and
the Warrant  Price shall be adjusted  pursuant  to the  provisions  hereof,  the
Company shall  forthwith  file, at its principal  executive  office a statement,
signed by the Chairman of the Board, President, or one of the Vice Presidents of
the  Company  and by its Chief  Financial  Officer or one of its  Treasurers  or
Assistant Treasurers,  stating the adjusted number of Warrant Shares and the new
Warrant  Price  calculated  to the nearest one  hundredth  and setting  forth in
reasonable  detail  the  method  of  calculation  and the facts  requiring  such
adjustment  and upon which such  calculation  is based.  Each  adjustment  shall
remain in effect until a subsequent  adjustment hereunder is required. A copy of
such statement shall be mailed to the Warrantholder.

          5.   CHARGES,  TAXES AND  EXPENSES. The issuance of  certificates  for
Warrant Shares upon any exercise of this Warrant shall be made without charge to
the  Warrantholder  for any tax or other  expense in respect to the  issuance of
such certificates, all of which taxes and expenses shall be paid by the Company,
and such certificates shall be issued only in the name of the Warrantholder.

          6.   MISCELLANEOUS.

               (1) The terms of this  Warrant  shall be  binding  upon and shall
inure to the  benefit of any  successors  or assigns of the  Company  and of the
holder or holders  hereof and of the shares of Common  Stock  issued or issuable
upon the exercise hereof.

               (2) No holder of this Warrant, as such, shall be entitled to vote
or receive  dividends  or be deemed to be a  stockholder  of the Company for any
purpose,  nor shall  anything  contained  in this Warrant be construed to confer
upon the holder of this Warrant,  as such,  any rights of a  stockholder  of the
Company or any right to vote, give or withhold consent to any corporate  action,
receive  notice of  meetings,  receive  dividends  or  subscription  rights,  or
otherwise.

               (3) Receipt of this Warrant by the holder hereof shall constitute
acceptance of an agreement to the foregoing terms and conditions.

               (4) The Warrant  and the  performance  of the  parties  hereunder
shall be construed and  interpreted in accordance  with the laws of the State of
New York and the parties  hereunder consent and agree that the State and Federal
Courts  which sit in the State of New York and the County of New York shall have
exclusive  jurisdiction  with respect to all  controversies and disputes arising
hereunder.


                                        6

<PAGE>




               (5) Shares issued upon exercise of this Warrant shall be legended
substantially as follows:

         "The  shares  evidenced  by this  certificate  have  not  been
         registered  under the Securities Act of 1933, as amended,  and
         must be held indefinitely unless they are transferred pursuant
         to an effective registration statement under that Act or after
         receipt of an opinion of counsel  satisfactory  to the Company
         that registration is not required."

                  IN WITNESS WHEREOF,  the Company has caused this Warrant to be
signed by its duly  authorized  officer  and its  corporate  seal to be  affixed
hereto.

Dated: November ___, 1998

                                                   ADVANCED VIRAL RESEARCH CORP.


                                                   BY:
                                                      ------------------------
                                                        Shalom Hirschman, M.D.
                                                        President


                                        7

<PAGE>


EXHIBIT E


                                   CERTIFICATE

         The   undersigned   desires  to  purchase   certain   securities   (the
"Securities")  to be issued by Advanced  Viral Research  Corp.  (the  "Company")
pursuant a Securities  Purchase Agreement (the "Agreement"),  dated November 16,
1998.

         The undersigned,  in connection with the  transactions  contemplated in
the Agreement, hereby certifies that:

         (a)      OFFSHORE TRANSACTION.

                           (i) The undersigned is not a U.S. Person as that term
                  is defined  under  Regulation  S under the  Securities  Act of
                  1933, as amended (the "Securities Act"), at the time the offer
                  and sale of the Securities are made to the undersigned;

                           (ii) The undersigned is purchasing the Securities for
                  its own account and not for the account or on behalf of any U.
                  S.  Person,  and no sale  has been  prearranged  with any U.S.
                  Person in the United States or its territories;

                           (iii) The  undersigned  has not  engaged in, and will
                  not during the Restricted Period (as defined below) engage in,
                  any short selling,  hedging or other similar transaction which
                  would  have the  effect of either  transferring  the  benefits
                  and/or  burdens of  ownership  of the  Securities  back to the
                  United States market during the Restricted Period;

                           (iv)  The  undersigned  is not and  will not act as a
                  distributor as defined in Rule 902 of Regulation S.

                           (v) The undersigned hereby agrees that the Securities
                  acquired by the  undersigned  pursuant to the Agreement  shall
                  not be voluntarily sold,  transferred or otherwise disposed of
                  for a minimum  period of one year from the date of  Closing of
                  the sale of the Securities to the undersigned (the "Restricted
                  Period");   unless  such   disposition  is  made  pursuant  to
                  Regulation S, an effective  registration  statement  under the
                  Securities   Act,  or  pursuant  to  an  exemption   from  the
                  registration requirements of the Securities Act.

                           (vi) The undersigned  understands that the Securities
                  are being  offered and sold to it in reliance on  Regulation S
                  under the Securities Act, and that the Company is relying upon
                  the truth and  accuracy  of the  representations,  warranties,
                  agreements,   acknowledgments   and   understandings   of  the
                  undersigned  set forth herein and in the Agreement in order to
                  determine   the   applicability   of   Regulation  S  and  the
                  suitability of the undersigned to acquire the Securities;


                                        8

<PAGE>


         (b)  NO  GOVERNMENT   RECOMMENDATION   OR  APPROVAL.   The  undersigned
understands  that  no  federal  or  state  agency  has  passed  on or  made  any
recommendation or endorsement of the Securities.


                                               ---------------------------------
                                                                , Participant


Date:    November    , 1998
                  ---
Place of Execution:
                   --------------------------



                                        2

<PAGE>


- --------------------------------------------------------------------------------








                          ADVANCED VIRAL RESEARCH CORP.
                                   $1,500,000
                            7% CONVERTIBLE DEBENTURE
                              DUE OCTOBER 31, 2008
                              WARRANTS TO PURCHASE
           750,000 SHARES OF COMMON STOCK, PAR VALUE $.00001 PER SHARE






                               PURCHASE AGREEMENT
                             DATED NOVEMBER 16, 1998










                          SECURITIES PURCHASE AGREEMENT







- --------------------------------------------------------------------------------


<PAGE>


                                TABLE OF CONTENTS

                                                                            Page
ARTICLE I
AUTHORIZATION OF THE SECURITIES.............................................. 1

ARTICLE II
SALE AND PURCHASE OF THE SECURITIES; CLOSING................................. 1
          2.1.        Sale and Purchase of the Securities.................... 1
          2.2.        Closing................................................ 2

ARTICLE III
REPRESENTATIONS AND WARRANTIES OF THE PURCHASER.............................. 2
          3.1.        Regulation S Offering.................................. 2
          3.2.        The Purchase and Purchaser............................. 2
          3.3.        Offshore Transaction................................... 3
          3.4.        Offering Restrictions.................................. 3
          3.5.        Beneficial Owner....................................... 3
          3.6.        Directed Selling Effort................................ 3
          3.7.        Short Position......................................... 4
          3.8.        Certificate of Participant............................. 4
          3.9.        Independent Investigation.............................. 4
          3.10.       No Government Recommendation or Approval............... 4
          3.11.       Further Limitations on Disposition..................... 4
          3.12.       Legal Representation................................... 4

ARTICLE IV
REPRESENTATIONS AND WARRANTIES OF THE COMPANY................................ 5
          4.1.        Organization and Existence, etc........................ 5
          4.2.        Subsidiaries and Affiliates............................ 5
          4.3.        Capitalization......................................... 6
          4.4.        Authorization.......................................... 6
          4.5.        Binding Obligations; No Material Adverse 
                         Contracts, etc...................................... 6
          4.6.        Financial Information.................................. 6
          4.7.        Compliance with Instruments, etc....................... 6
          4.8.        Litigation............................................. 7
          4.9.        Offering............................................... 7
          4.10.       Permits; Governmental and Other Approvals.............. 7
          4.11.       Reporting Company Status............................... 7
          4.12.       Offshore Transaction................................... 7
          4.13.       Prearranged Sale....................................... 7
          4.14.       No Directed Selling Efforts............................ 7
          4.15.       Copyrights, Trademarks and Patents..................... 8
          4.16.       No Relationship Between Parties........................ 8



<PAGE>



          4.17.       Other Material Contracts............................... 8
          4.18        Registration of Transfer of Securities..................8
          4.19.       Disclosure............................................. 8

ARTICLE V
CONDITIONS TO CLOSING OF THE PURCHASER....................................... 8
          5.1.        Representations and Warranties Correct................. 8
          5.2.        Performance............................................ 9
          5.3.        No Impediments......................................... 9
          5.4.        Other Agreements....................................... 9
          5.5.        Legal Investment....................................... 9
          5.6.        Due Diligence Investigation............................ 9
          5.7.        Proceedings and Other Documents........................ 9

ARTICLE VI
CONDITIONS TO CLOSING OF THE COMPANY......................................... 9
          6.1.        Representations........................................ 9
          6.2.        Legal Investment....................................... 9
          6.3.        Payment of Purchase Price............................. 10

ARTICLE VII
OPTIONAL PREPAYMENTS........................................................ 10
          7.1.        Optional Prepayments.................................. 10
          7.2.        Notice of Prepayment.................................. 10
          7.3.        Exercise of Conversion Privilege Upon
                      Receipt of Prepayment Notice.......................... 10

ARTICLE VIII
AFFIRMATIVE COVENANTS....................................................... 10
          8.1.        Maintenance of Corporate Existence,
                      Properties and Leases; Taxes; Insurance............... 10
          8.2.        Basic Financial Information........................... 11
          8.3.        Notice of Adverse Change.............................. 12
          8.4.        Compliance With Agreements; Compliance With Laws...... 13
          8.5.        Protection of Licenses, etc........................... 13
          8.6.        Accounts and Records; Inspections..................... 13
          8.7.        Further Assurances.................................... 14
          8.8.        Registration Rights................................... 14


ARTICLE IX
EVENTS OF DEFAULTS.......................................................... 15
          9.1.        Events of Default..................................... 15
          9.2.        Remedies.............................................. 17



<PAGE>



          9.3.        Enforcement........................................... 17

ARTICLE X
AMENDMENT AND WAIVER........................................................ 18

ARTICLE XI
EXCHANGE AND REPLACEMENT OF DEBENTURES...................................... 18

ARTICLE XII
TRANSFER OF AND PAYMENT OF DEBENTURES....................................... 19
          12.1.       Notification of Proposed Sale......................... 19
          12.2.       Payment............................................... 19

ARTICLE XIII
MISCELLANEOUS............................................................... 20
          13.1.       Governing Law......................................... 20
          13.2.       Survival.............................................. 20
          13.3.       Successors and Assigns................................ 20
          13.4.       Entire Agreement...................................... 20
          13.5.       Notices, etc.......................................... 21
          13.6.       Delays or Omissions................................... 21
          13.7.       Rights; Severability.................................. 21
          13.8.       Placement Fee......................................... 21
          13.9.       Expenses.............................................. 22
          13.10.      Litigation............................................ 22
          13.11.      Titles and Subtitles.................................. 23
          13.12.      Counterparts.......................................... 23



Exhibit A    -  Form of 7% Convertible Debenture
Exhibit B    -  Name and Address of Purchaser; Purchase Prices for Securities
Exhibit C    -  Schedule of Exceptions
Exhibit D-1  -  Form of Warrant
Exhibit D-2  -  Form of Warrant
Exhibit E    -  Form of Certificate of Participant




EXHIBIT 99.2

           THIS DEBENTURE AND THE SHARES OF COMMON STOCK ISSUABLE UPON
        THE CONVERSION OF THIS DEBENTURE (COLLECTIVELY, THE "SECURITIES")
          HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS
        AMENDED (THE "SECURITIES ACT"), AND MAY NOT BE OFFERED OR SOLD IN
        THE UNITED STATES OR TO U.S. PERSONS (AS DEFINED IN REGULATION S
         UNDER THE SECURITIES ACT) UNLESS IN ACCORDANCE WITH REGULATION
         S, PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT, OR PURSUANT
          TO AN AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS
           UNDER THE SECURITIES ACT. IN ADDITION, HEDGING TRANSACTIONS
             INVOLVING THE SECURITIES MAY NOT BE CONDUCTED UNLESS IN
                       COMPLIANCE WITH THE SECURITIES ACT.

                  7% CONVERTIBLE DEBENTURE DUE OCTOBER 31, 2008


$1,500,000                                                     November 16, 1998
                                                              New York, New York

              FOR VALUE  RECEIVED,  ADVANCED  VIRAL  RESEARCH  CORP., a Delaware
corporation (the "undersigned" or the "Company"),  hereby promises to pay to the
order of RBB BANK  AKTIENGESELLSCHAFT,  at its offices  located at Burgring  16,
8010 Graz,  Austria or at such other place as the holder hereof shall  designate
to the  undersigned in writing,  in lawful money of the United States of America
or in New York Clearing  House Funds,  the principal  amount of One Million Five
Hundred  Thousand  Dollars,  and to pay  interest  (computed  on the  basis of a
360-day  year and the actual  number of days  elapsed)  on the unpaid  principal
amount  hereof at the rate of seven  (7%)  percent  per annum.  The  undersigned
promises to pay the said principal sum and interest as follows:

              Until this Debenture is completely  retired the undersigned  shall
make payments of accrued  interest on this Debenture on the first day of January
and July in each year (commencing with January 1, 1999), computed at the rate of
7% per annum on the unpaid  principal  balance of this  Debenture for the period
from the date of this  Debenture  until the date of such  interest  payment.  On
October 31, 2008 the undersigned  shall pay the holder all unpaid  principal and
interest on this Debenture.

              Interest on the  indebtedness  evidenced by this  Debenture  after
default or maturity  accelerated  or  otherwise  shall be due and payable at the
rate of ten (10%) percent per annum,  subject to the  limitations  of applicable
law.

              If  this  Debenture  or any  installment  hereof  becomes  due and
payable on a Saturday,  Sunday or public  holiday under the laws of the State of
New York, the due date hereof shall be extended to the next succeeding  business
day and interest shall be payable at the rate of seven (7%)


<PAGE>


percent per annum during such  extension.  All  payments  received by the holder
shall be applied first to the payment of all accrued interest payable hereunder.

              Subject  to and in  compliance  with the  provisions  hereof,  the
holder  shall  have the right to  convert  all or a portion  of the  outstanding
principal  amount of this  Debenture into such number of shares of Common Stock,
par value  $.00001 per share,  of the Company  ("Common  Stock")  (the shares of
Common Stock issuable upon conversion of this Debenture are hereinafter referred
to as the "Conversion  Shares") as shall equal the quotient obtained by dividing
(x) the principal amount of this Debenture to be converted by (y) the Applicable
Conversion  Price (as  hereinafter  defined) and by surrender of this Debenture,
such surrender to be made in the manner provided herein; provided, however, that
the right to convert outstanding  principal of this Debenture shall terminate at
the close of business on the third  calendar  day  preceding  the date fixed for
prepayment unless the Company shall default in making such prepayment.

          For purposes hereof the term "Applicable  Conversion Price" shall mean
the lesser of (q) $0.20 and (r) the  product  obtained  by  multiplying  (i) the
Average Closing Price (as hereinafter defined) by (iii) .72.

          For purposes  hereof the "Average  Closing  Price" with respect to any
conversion  elected to be made by the holder  shall be the  average of the daily
closing  prices for the three  consecutive  trading  days,  as  selected  by the
holder, out of the ten trading days immediately  preceding the date on which the
holder gives the Company a written  notice of the  holder's  election to convert
outstanding  principal of this  Debenture.  The closing price on any trading day
shall be (a) if the  Common  Stock is then  listed or quoted on either  the NASD
Bulletin Board,  the NASDAQ SmallCap Market or the NASDAQ National  Market,  the
reported closing bid price for the Common Stock on such day or (b) if the Common
Stock is  listed  on  either  the  American  Stock  Exchange  or New York  Stock
Exchange, the last reported sales price for the Common Stock on such exchange on
such day.

          On the date notice is delivered  in order to exercise  its  conversion
right,  the holder shall  surrender this Debenture to the Company at its office,
accompanied  by written  notice to the Company that the holder  hereof elects to
convert  all  or a  specified  portion  of the  outstanding  principal  of  this
Debenture (the "Conversion Notice"). Within five (5) business days after receipt
of this Debenture and the Conversion  Notice, the Company will pay to the holder
all interest  accrued on the principal  amount of this Debenture to be converted
to the effective date of conversion or, at the sole option of the Company, issue
to the holder in lieu thereof such  additional  number of shares of Common Stock
as shall equal the  quotient  obtained by dividing  the total  amount of accrued
interest  on the  principal  amount of this  Debenture  to be  converted  by the
Applicable  Conversion Price.  Within five (5) business days after the surrender
of this Debenture,  as aforesaid,  the Company shall cause its transfer agent to
issue and deliver to such holder,  or on its written  order,  a  certificate  or
certificates  without any restrictive legend thereon for the number of shares of
Common  Stock  issuable  upon  the  conversion  hereof  in  accordance  with the
provisions of this Debenture,  and any fractional interest in respect of a share
of Common Stock  arising upon such  conversion  shall be settled as  hereinafter
provided.  If the  Company  fails to  deliver  to the  holder a  certificate  or
certificates  for shares of Common Stock as aforesaid prior to the expiration of
five (5) business days after receipt of the  Conversion  Notice and surrender to
the Company of the Debenture, the Company


<PAGE>


shall  pay to  the  holder  a  penalty.  The  penalty  shall  be  $1,000  if the
certificate or certificates are not delivered until the sixth business day after
the  delivery  of the  Conversion  Notice and the  penalty  shall  double  every
business day until the certificate or certificates  are so delivered,  but in no
event shall such penalty exceed $100,000.  For example,  if the certificates are
delivered on the eighth business day after delivery of the Conversion Notice and
surrender of the Debenture the penalty shall be $4,000.

          If the entire  outstanding  principal  amount of this Debenture is not
converted,  the  Company  shall  also  issue and  deliver  to such  holder a new
Debenture of like tenor in the principal amount equal to the principal which was
not converted and dated the effective date of conversion.  Each conversion shall
be deemed to have been  effected  immediately  prior to the close of business on
the date on which this  Debenture  shall have been  surrendered  and such notice
received by the Company as aforesaid, and the person or persons in whose name or
names any  certificate  of  certificates  for  shares of Common  Stock  shall be
issuable  upon such  conversion  shall be deemed to have  become  the  holder or
holders of record of the shares  represented  thereby at such time on such date.
All shares of Common Stock  delivered upon  conversion of this  Debenture  will,
upon  delivery,   be  duly  authorized,   validly  issued  and  fully  paid  and
nonassessable.  No  fractional  shares of  Common  Stock  shall be  issued  upon
conversion of this  Debenture.  Instead of any fractional  share of Common Stock
which would otherwise be deliverable  upon the conversion of a principal of this
Debenture the Company shall pay to the holder an amount in cash (computed to the
nearest cent) equal to the Average Closing Price multiplied by the fraction of a
share of Common Stock represented by such fractional interest.

              The issuance of  certificates  for shares of Common Stock upon any
conversion of this  Debenture  shall be made without  charge to the payee hereof
for any tax or other  expense in respect to the  issuance of such  certificates,
all of  which  taxes  and  expenses  shall  be paid  by the  Company,  and  such
certificates  shall be issued only in the name of the registered  holder of this
Debenture.

              This Debenture has been issued pursuant to and shall be subject to
all of the  provisions of the Purchase  Agreement.  The payee is entitled to the
benefits  of the  Purchase  Agreement,  and this  Debenture  may be  prepaid  as
provided in the Purchase Agreement. Reference is made to Sections 7.2 and 7.3 of
the Purchase  Agreement  with respect to certain rights of the holder to convert
this Debenture into Common Stock upon receipt of a notice of prepayment.

              Upon the  occurrence  of any one or more of the  events of default
specified or referred to in the Purchase  Agreement or in the other documents or
instruments executed in connection therewith,  all amounts then remaining unpaid
on this Debenture may be declared to be immediately  due and payable as provided
in the Purchase Agreement.

              In the event that this  Debenture  shall be placed in the hands of
an attorney  for  collection  by reason of any event of default  hereunder,  the
undersigned agrees to pay reasonable attorney's fees and disbursements and other
reasonable  expenses  incurred by the payee in connection with the collection of
this Debenture.


<PAGE>


              The  rights,  powers and  remedies  given to the payee  under this
Debenture shall be in addition to all rights, powers and remedies given to it by
virtue of the  Purchase  Agreement,  any  document  or  instrument  executed  in
connection therewith, or any statute or rule of law.

              Any  forbearance,  failure or delay by the payee in exercising any
right,  power or remedy  under  this  Debenture,  the  Purchase  Agreement,  any
documents or instruments executed in connection therewith or otherwise available
to the payee shall not be deemed to be a waiver of such right,  power or remedy,
nor shall any single or partial exercise of any right,  power or remedy preclude
the further exercise thereof.

              No modification or waiver of any provision of this Debenture,  the
Purchase  Agreement  or any  documents  or  instruments  executed in  connection
therewith  shall be  effective  unless it shall be in writing  and signed by the
payee,  and any such  modification  or waiver  shall apply only in the  specific
instance for which given.

              This  Debenture  and the rights  and  obligations  of the  parties
hereto,  shall be governed,  construed and interpreted  according to the laws of
the State of New York,  and the  undersigned  consents and agrees that the State
and Federal Courts which sit in the State of New York,  County of New York shall
have exclusive jurisdiction of all controversies and disputes arising hereunder.

              The term  "payee" as used  herein  shall be deemed to include  the
payee and its successors, endorsees and assigns.

              The  undersigned  hereby waives  presentment,  demand for payment,
protest, notice of protest and notice of non-payment hereof.



                  By:   \s\ Shalom Hirschman
                     -----------------------------------------
                      Shalom Z. Hirschman, M.D., President and
                      Chief Executive Officer




EXHIBIT 99.3

          THIS WARRANT AND THE SHARES OF COMMON STOCK ISSUABLE UPON THE
         EXERCISE OF THIS WARRANT (COLLECTIVELY, THE "SECURITIES") HAVE
        NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED
          (THE "SECURITIES ACT"), AND MAY NOT BE OFFERED OR SOLD IN THE
       UNITED STATES OR TO U.S. PERSONS (AS DEFINED IN REGULATION S UNDER
           THE SECURITIES ACT) UNLESS IN ACCORDANCE WITH REGULATION S,
         PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT, OR PURSUANT TO
            AN AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS
           UNDER THE SECURITIES ACT. IN ADDITION, HEDGING TRANSACTIONS
             INVOLVING THE SECURITIES MAY NOT BE CONDUCTED UNLESS IN
                       COMPLIANCE WITH THE SECURITIES ACT.


                               WARRANT TO PURCHASE

                    COMMON STOCK, PAR VALUE $.00001 PER SHARE

                                       OF

                          ADVANCED VIRAL RESEARCH CORP.
              ----------------------------------------------------


              This   certifies    that,   for   value    received,    RBB   BANK
AKTIENGESELLSCHAFT,  or  registered  assigns  ("Warrantholder"),  is entitled to
purchase from ADVANCED  VIRAL  RESEARCH CORP.  (the  "Company"),  subject to the
provisions  of this  Warrant,  at any time and from time to time until 5:00 p.m.
Eastern  Standard  Time on October 31,  2008,  375,000  shares of the  Company's
Common Stock, par value $.00001 per share ("Warrant Shares"). The purchase price
payable upon the exercise of this Warrant shall be $0.20 per Warrant Share.  The
Warrant  Price and the  number of  Warrant  Shares  which the  Warrantholder  is
entitled  to  purchase  is  subject to  adjustment  upon the  occurrence  of the
contingencies set forth in Section 3 of this Warrant,  and as adjusted from time
to time, such purchase price is hereinafter referred to as the "Warrant Price."

              This Warrant is subject to the following terms and conditions:

1.        EXERCISE OF WARRANT.
                  (1)      This Warrant may be exercised in whole or in part but
                           not for a  fractional  share.  Upon  delivery of this
                           Warrant  at the  offices  of the  Company  or at such
                           other  address as the Company may designate by notice
                           in writing to the  registered  holder hereof with the
                           Subscription   Form  annexed  hereto  duly  executed,
                           accompanied by payment of the Warrant


<PAGE>


                           Price for the number of Warrant Shares  purchased (in
                           cash,   by   certified,   cashier's  or  other  check
                           acceptable  to the  Company,  by Common  Stock of the
                           Company   having  a  Market  Value  (as   hereinafter
                           defined) equal to the aggregate Warrant Price for the
                           Warrant Shares to be purchased, or any combination of
                           the foregoing), the registered holder of this Warrant
                           shall  be  entitled  to  receive  a  certificate   or
                           certificates  for the  Warrant  Shares so  purchased.
                           Such  certificate or  certificates  shall be promptly
                           delivered  to the  Warrantholder.  Upon  any  partial
                           exercise of this  Warrant,  the Company shall execute
                           and  deliver  a new  Warrant  of like  tenor  for the
                           balance of the Warrant Shares purchasable hereunder.

                  (2)      In  lieu  of  exercising  this  Warrant  pursuant  to
                           Section 1(1),  the holder may elect to receive shares
                           of Common  Stock  equal to the value of this  Warrant
                           determined  in the  manner  described  below  (or any
                           portion thereof remaining  unexercised) upon delivery
                           of this  Warrant at the  offices of the Company or at
                           such other  address as the Company may  designate  by
                           notice in writing  to the  registered  holder  hereof
                           with the Notice of  Cashless  Exercise  Form  annexed
                           hereto duly executed. In such event the Company shall
                           issue  to  the  holder  a  number  of  shares  of the
                           Company's  Common Stock  computed using the following
                           formula:

                                   X = Y (A-B)
                                       -------
                                        A

Where    X = the number of shares of Common Stock to be issued to the holder.
         Y = the number of shares of Common Stock purchasable under this Warrant
             (at the date of such calculation).
         A = the Market Value of the Company's  Common Stock on the business day
             immediately  preceding  the day on which  the  Notice  of  Cashless
             Exercise is received by the Company.
         B = Warrant Price (as adjusted to the date of such calculation).

                  (3)      The Warrant Shares deliverable  hereunder shall, upon
                           issuance,  be fully paid and  non-assessable  and the
                           Company  agrees that at all times  during the term of
                           this  Warrant  it  shall  cause  to be  reserved  for
                           issuance such number of shares of its Common Stock as
                           shall be required  for  issuance  and  delivery  upon
                           exercise of this Warrant.

                  (4)      For purposes of this  Warrant,  the Market Value of a
                           share of Common  Stock on any date  shall be equal to
                           (i) the closing  sale price per share as published by
                           a national  securities  exchange  on which  shares of
                           Common  Stock (or other  units of the  security)  are
                           traded (an  "Exchange")  on such date or, if there is
                           no sale of Common Stock on such date,  the average of
                           the bid and  asked  prices  on such  exchange  at the
                           close of trading  on such date or,  (ii) if shares of
                           Common Stock are not listed on a national  securities
                           exchange on such date, the closing price per share as
                           published on the National  Association  of Securities
                           Dealers Automatic Quotation System


<PAGE>


                           ("NASDAQ")  National  Market System if the shares are
                           quoted  on such  system  on such  date,  or (iii) the
                           average   of  the  bid  and   asked   prices  in  the
                           over-the-counter  market at the close of  trading  on
                           such date if the shares are not traded on an exchange
                           or listed on the NASDAQ  National  Market System,  or
                           (iv) if the Common  Stock is not traded on a national
                           securities   exchange  or  in  the   over-the-counter
                           market,  the fair  market  value of a share of Common
                           Stock on such date as determined in good faith by the
                           Board of Directors.  If the holder disagrees with the
                           determination  of the Market Value of any  securities
                           of the Company  determined  by the Board of Directors
                           under  Section  1(4)(iv)  the  Market  Value  of such
                           securities  shall  be  determined  by an  independent
                           appraiser  acceptable  to the  Company and the holder
                           (or, if they cannot agree on such an appraiser, by an
                           independent  appraiser  selected by each of them, and
                           Market  Value  shall be the median of the  appraisals
                           made by such appraisers).  If there is one appraiser,
                           the cost of the  appraisal  shall be  shared  equally
                           between the Company and the holder.  If there are two
                           appraisers,  each of the Company and the holder shall
                           pay for its own appraisal.

2.       TRANSFER OR ASSIGNMENT OF WARRANT.

                  (1)      Any  assignment  or transfer of this Warrant shall be
                           made by  surrender  of this Warrant at the offices of
                           the  Company or at such other  address as the Company
                           may  designate  in writing to the  registered  holder
                           hereof with the  Assignment  Form annexed hereto duly
                           executed and  accompanied by payment of any requisite
                           transfer  taxes,  and  the  Company  shall,   without
                           charge,  execute  and  deliver a new  Warrant of like
                           tenor in the name of the  assignee for the portion so
                           assigned in case of only a partial assignment, with a
                           new  Warrant  of like tenor to the  assignor  for the
                           balance of the Warrant Shares purchasable.

                  (2)      Prior to any  assignment or transfer of this Warrant,
                           the  holder  thereof  shall  deliver  an  opinion  of
                           counsel  to  the  Company  to  the  effect  that  the
                           proposed    transfer   may   be   effected    without
                           registration under the Act.

3.       ADJUSTMENT OF WARRANT PRICE AND WARRANT SHARES -- ANTI-DILUTION
         PROVISIONS.

                                    A. (1) Except as  hereinafter  provided,  in
                           case the  Company  shall at any time  after  the date
                           hereof  issue any shares of Common  Stock  (including
                           shares  held  in  the  Company's   treasury)  without
                           consideration, then, and thereafter successively upon
                           each   issuance,   the   Warrant   Price  in   effect
                           immediately   prior  to  each  such  issuance   shall
                           forthwith  be  reduced  to  a  price   determined  by
                           multiplying  the Warrant Price in effect  immediately
                           prior to such issuance by a fraction:

                                    (a) the  numerator  of  which  shall be the
                                        total  number of shares of Common  Stock
                                        outstanding  immediately  prior  to such
                                        issuance, and


<PAGE>


                                    (b) the  denominator  of  which shall be the
                                        total  number of shares of Common  Stock
                                        outstanding   immediately   after   such
                                        issuance.

          For the purposes of any  computation to be made in accordance with the
provisions of this clause (1), the following provisions shall be applicable:

                                        (i)       Shares   of    Common    Stock
                                                  issuable by way of dividend or
                                                  other   distribution   on  any
                                                  stock of the Company  shall be
                                                  deemed to have been issued and
                                                  to be outstanding at the close
                                                  of business on the record date
                                                  fixed for the determination of
                                                  stockholders    entitled    to
                                                  receive such dividend or other
                                                  distribution   and   shall  be
                                                  deemed  to  have  been  issued
                                                  without consideration.  Shares
                                                  of   Common    Stock    issued
                                                  otherwise  than as a dividend,
                                                  shall be  deemed  to have been
                                                  issued  and to be  outstanding
                                                  at the  close of  business  on
                                                  the date of issue.

                                        (ii)      The number of shares of Common
                                                  Stock at any time  outstanding
                                                  shall not  include  any shares
                                                  then  owned  or held by or for
                                                  the account of the Company.

                                        (2) In case  the  Company  shall  at any
                              time subdivide or combine the  outstanding  shares
                              of Common Stock, the Warrant Price shall forthwith
                              be  proportionately  decreased  in the case of the
                              subdivision  or  proportionately  increased in the
                              case of  combination  to the nearest one cent. Any
                              such  adjustment  shall  become  effective  at the
                              close  of   business   on  the  date   that   such
                              subdivision or combination shall become effective.

                           B. In the event that the number of outstanding shares
                  of Common Stock is increased  by a stock  dividend  payable in
                  shares of Common Stock or by a subdivision of the  outstanding
                  shares of Common Stock,  which may include a stock split, then
                  from and after the time at which the  adjusted  Warrant  Price
                  becomes  effective  pursuant to the foregoing  Subsection A of
                  this Section by reason of such  dividend or  subdivision,  the
                  number of shares  issuable  upon the  exercise of this Warrant
                  shall  be  increased  in   proportion   to  such  increase  in
                  outstanding   shares.   In  the  event   that  the  number  of
                  outstanding   shares  of  Common   Stock  is  decreased  by  a
                  combination of the outstanding  shares of Common Stock,  then,
                  from and after the time at which the  adjusted  Warrant  Price
                  becomes  effective  pursuant  to  such  Subsection  A of  this
                  Section  by reason of such  combination,  the number of shares
                  issuable  upon the exercise of this Warrant shall be decreased
                  in proportion to such decrease in outstanding shares.


<PAGE>


                           C.  In the  event  of an  adjustment  of the  Warrant
                  Price,  the number of shares of Common Stock (or  reclassified
                  stock)  issuable  upon  exercise  of this  Warrant  after such
                  adjustment  shall  be  equal  to  the  number   determined  by
                  dividing:

                              (1)       an amount  equal to the  product  of (i)
                                        the  number of  shares  of Common  Stock
                                        issuable  upon  exercise of this Warrant
                                        immediately  prior  to such  adjustment,
                                        and (ii) the Warrant  Price  immediately
                                        prior to such adjustment, by

                              (2)       the Warrant Price immediately after such
                                        adjustment.

                           D.   In   the   case   of   any   reorganization   or
                  reclassification  of the  outstanding  shares of Common  Stock
                  (other than a change in par value, or from par value to no par
                  value,  or from no par value to par value, or as a result of a
                  subdivision   or   combination)   or  in  the   case   of  any
                  consolidation  of the Company  with,  or merger of the Company
                  with, another  corporation,  or in the case of any sale, lease
                  or conveyance of all, or  substantially  all, of the property,
                  assets, business and goodwill of the Company as an entity, the
                  holder of this Warrant  shall  thereafter  have the right upon
                  exercise  to  purchase  the kind and amount of shares of stock
                  and  other  securities  and  property   receivable  upon  such
                  reorganization,  reclassification,  consolidation,  merger  or
                  sale by a holder of the number of shares of Common Stock which
                  the holder of this Warrant would have received had all Warrant
                  Shares  issuable  upon  exercise of this  Warrant  been issued
                  immediately  prior to such  reorganization,  reclassification,
                  consolidation, merger or sale, at a price equal to the Warrant
                  Price then in effect  pertaining  to this  Warrant  (the kind,
                  amount  and price of such  stock and  other  securities  to be
                  subject to adjustment as herein provided).

                           E. In case the  Company  shall,  at any time prior to
                  the  expiration  of this  Warrant  and  prior to the  exercise
                  thereof,  dissolve,  liquidate  or  wind up its  affairs,  the
                  Warrantholder shall be entitled, upon the exercise thereof, to
                  receive, in lieu of the Warrant Shares of the Company which it
                  would have been entitled to receive,  the same kind and amount
                  of assets as would have been issued, distributed or paid to it
                  upon  such  Warrant  Shares  of the  Company,  had it been the
                  holder of record of shares of Common Stock receivable upon the
                  exercise   of  this   Warrant  on  the  record  date  for  the
                  determination   of  those   entitled   to  receive   any  such
                  liquidating   distribution.   After   any  such   dissolution,
                  liquidation   or  winding  up  which   shall   result  in  any
                  distribution  in excess of the Warrant  Price  provided for by
                  this Warrant, the Warrantholder may at its option exercise the
                  same without making payment of the aggregate Warrant Price and
                  in such case the Company shall upon the  distribution  to said
                  Warrantholder  consider that the  aggregate  Warrant Price has
                  been  paid  in  full to it and in  making  settlement  to said
                  Warrantholder,  shall  deduct from the amount  payable to such
                  Warrantholder an amount equal to the aggregate Warrant Price.

                           F. In case the  Company  shall,  at any time prior to
                  the  expiration  of this  Warrant  and  prior to the  exercise
                  thereof make a distribution of assets (other than


<PAGE>


                  cash) or  securities of the Company to its  stockholders  (the
                  "Distribution") the Warrantholder shall be entitled,  upon the
                  exercise  thereof,  to  receive,  in  addition  to the Warrant
                  Shares it is entitled to receive,  the same kind and amount of
                  assets or securities as would have been  distributed  to it in
                  the Distribution had it been the holder of record of shares of
                  Common Stock  receivable  upon exercise of this Warrant on the
                  record date for determination of those entitled to receive the
                  Distribution.

                           G.  Irrespective  of any adjustments in the number of
                  Warrant  Shares and the Warrant Price or the number or kind of
                  shares purchasable upon exercise of this Warrant, this Warrant
                  may  continue to express the same price and number and kind of
                  shares as originally issued.

4.   OFFICER'S CERTIFICATE.  Whenever  the  number  of  Warrant  Shares  and the
Warrant Price shall be adjusted pursuant to the provisions  hereof,  the Company
shall forthwith file, at its principal  executive office a statement,  signed by
the  Chairman  of the Board,  President,  or one of the Vice  Presidents  of the
Company and by its Chief Financial Officer or one of its Treasurers or Assistant
Treasurers,  stating the adjusted  number of Warrant  Shares and the new Warrant
Price  calculated  to the nearest one  hundredth and setting forth in reasonable
detail the method of calculation  and the facts  requiring  such  adjustment and
upon which such  calculation is based.  Each  adjustment  shall remain in effect
until a subsequent  adjustment  hereunder is required.  A copy of such statement
shall be mailed to the Warrantholder.

5.   CHARGES,  TAXES AND EXPENSES. The  issuance  of  certificates  for  Warrant
Shares upon any  exercise of this Warrant  shall be made  without  charge to the
Warrantholder  for any tax or other  expense in respect to the  issuance of such
certificates,  all of which taxes and expenses shall be paid by the Company, and
such certificates shall be issued only in the name of the Warrantholder.

6.   MISCELLANEOUS.

                    (1)       The terms of this  Warrant  shall be binding  upon
                              and shall inure to the  benefit of any  successors
                              or  assigns  of the  Company  and of the holder or
                              holders  hereof and of the shares of Common  Stock
                              issued or issuable upon the exercise hereof.

                    (2)       No  holder  of this  Warrant,  as  such,  shall be
                              entitled to vote or receive dividends or be deemed
                              to  be  a  stockholder  of  the  Company  for  any
                              purpose,  nor  shall  anything  contained  in this
                              Warrant be  construed to confer upon the holder of
                              this Warrant, as such, any rights of a stockholder
                              of the  Company  or any  right  to  vote,  give or
                              withhold consent to any corporate action,  receive
                              notice   of   meetings,   receive   dividends   or
                              subscription rights, or otherwise.

                    (3)       Receipt of this Warrant by the holder hereof shall
                              constitute  acceptance  of  an  agreement  to  the
                              foregoing terms and conditions.


<PAGE>


                    (4)       The  Warrant  and the  performance  of the parties
                              hereunder  shall be construed and  interpreted  in
                              accordance  with the laws of the State of New York
                              and the parties  hereunder  consent and agree that
                              the  State  and  Federal  Courts  which sit in the
                              State of New York and the County of New York shall
                              have  exclusive  jurisdiction  with respect to all
                              controversies and disputes arising hereunder.

                    (5)       Shares  issued upon exercise of this Warrant shall
                              be legended substantially as follows:

         "The  shares  evidenced  by this  certificate  have  not  been
         registered  under the Securities Act of 1933, as amended,  and
         must be held indefinitely unless they are transferred pursuant
         to an effective registration statement under that Act or after
         receipt of an opinion of counsel  satisfactory  to the Company
         that registration is not required."

                  IN WITNESS WHEREOF,  the Company has caused this Warrant to be
signed by its duly  authorized  officer  and its  corporate  seal to be  affixed
hereto.

Dated: November 16, 1998

                                   ADVANCED VIRAL RESEARCH CORP.



                                   BY: \s\ Shalom Hirschman
                                      -----------------------------------
                                        Shalom Hirschman, M.D., President

<PAGE>


                                SUBSCRIPTION FORM


                    (TO BE EXECUTED BY THE REGISTERED HOLDER
                     IF HE DESIRES TO EXERCISE THE WARRANT)


         To:      ADVANCED VIRAL RESEARCH CORP.


                  The  undersigned   hereby  exercises  the  right  to  purchase
_________  shares of Common Stock,  par value $.00001 per share,  covered by the
attached  Warrant  in  accordance  with the terms and  conditions  thereof,  and
herewith makes payment of the Warrant Price for such shares in full.


                                    -------------------------------------------
                                    SIGNATURE


                                    --------------------------------------------
                                    ADDRESS

                                    --------------------------------------------



DATED:
      --------------------


<PAGE>


                   NOTICE OF EXERCISE OF COMMON STOCK WARRANT
             PURSUANT TO NET ISSUE ("CASHLESS") EXERCISE PROVISIONS


                                                                        , 199   
                                                            ------------     ---


Advanced Viral Research Corp.        Aggregate Price of          $
a Delaware corporation               of Warrant                   --------------
200 Corporate Boulevard South
Yonkers, New York 10701              Aggregate Price Being
                                     Exercised:                  $
Attention:                                                        --------------
          --------------------       Warrant Price
                                     (per share):                $
                                     Number of Shares of          --------------
                                     Common Stock to be
                                     Issued Under this
                                     Notice:



                                CASHLESS EXERCISE


Gentlemen:

                  The undersigned,  registered holder of the Warrant to Purchase
Common Stock delivered herewith  ("Warrant")  hereby irrevocably  exercises such
Warrant for, and  purchases  thereunder,  shares of the Common Stock of ADVANCED
VIRAL RESEARCH CORP., a Delaware  corporation,  as provided  below.  Capitalized
terms used herein,  unless  otherwise  defined  herein,  shall have the meanings
given in the  Warrant.  The  portion  of the  Aggregate  Price  (as  hereinafter
defined)  to be applied  toward the  purchase of Common  Stock  pursuant to this
Notice of Exercise is $ , thereby  leaving a remainder  Aggregate Price (if any)
equal to $
        . Such exercise shall be pursuant to the net issue  exercise  provisions
of Section 1(b) of the Warrant; therefore, the holder makes no payment with this
Notice of Exercise.  The number of shares to be issued pursuant to this exercise
shall be  determined  by reference to the formula in Section 1(b) of the Warrant
which  requires  the use of the Market  Value (as defined in Section 1(d) of the
Warrant) of the Company's Common Stock on the business day immediately preceding
the day on which  this  Notice is  received  by the  Company.  To the extent the
foregoing exercise is for less than the full Aggregate Price of the Warrant, the
remainder of the Warrant  representing  a number of Shares equal to the quotient
obtained by dividing the remainder of the  Aggregate  Price by the Warrant Price
(and otherwise of like form, tenor and effect) may be exercised under Section


<PAGE>


1(a) of the  Warrant.  For  purposes of this Notice the term  "Aggregate  Price"
means the product  obtained by multiplying  the number of shares of Common Stock
for which the Warrant is exercisable times the Warrant Price.


                                    -------------------------------------------
                                    SIGNATURE

DATE:
     --------------------           --------------------------------------------
                                    ADDRESS


                                        2

<PAGE>


                                   ASSIGNMENT


                    (To be Executed by the Registered Holder
                     if he Desires to Transfer the Warrant)


                  FOR VALUE RECEIVED,  the undersigned hereby sells, assigns and
transfers  unto                          the right to purchase  shares of Common
Stock of ADVANCED VIRAL RESEARCH  CORP.,  evidenced by the within  Warrant,  and
does hereby irrevocably constitute and appoint                          Attorney
to transfer  the said  Warrant on the books of the  Company,  with full power of
substitution.


                                    -------------------------------------------
                                    SIGNATURE


                                    --------------------------------------------
                                    ADDRESS

DATED:
      ---------------------

IN THE PRESENCE OF:


- ---------------------------





EXHIBIT 99.4

          THIS WARRANT AND THE SHARES OF COMMON STOCK ISSUABLE UPON THE
         EXERCISE OF THIS WARRANT (COLLECTIVELY, THE "SECURITIES") HAVE
        NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED
          (THE "SECURITIES ACT"), AND MAY NOT BE OFFERED OR SOLD IN THE
       UNITED STATES OR TO U.S. PERSONS (AS DEFINED IN REGULATION S UNDER
           THE SECURITIES ACT) UNLESS IN ACCORDANCE WITH REGULATION S,
         PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT, OR PURSUANT TO
            AN AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS
           UNDER THE SECURITIES ACT. IN ADDITION, HEDGING TRANSACTIONS
             INVOLVING THE SECURITIES MAY NOT BE CONDUCTED UNLESS IN
                       COMPLIANCE WITH THE SECURITIES ACT.


                               WARRANT TO PURCHASE

                    COMMON STOCK, PAR VALUE $.00001 PER SHARE

                                       OF

                          ADVANCED VIRAL RESEARCH CORP.

              -----------------------------------------------------


                  This   certifies   that,   for   value   received,   RBB  BANK
AKTIENGESELLSCHAFT,  or  registered  assigns  ("Warrantholder"),  is entitled to
purchase from ADVANCED  VIRAL  RESEARCH CORP.  (the  "Company"),  subject to the
provisions  of this  Warrant,  at any time and from time to time until 5:00 p.m.
Eastern  Standard  Time on October 31,  2008,  375,000  shares of the  Company's
Common Stock, par value $.00001 per share ("Warrant Shares"). The purchase price
payable upon the exercise of this Warrant shall be $0.24 per Warrant Share.  The
Warrant  Price and the  number of  Warrant  Shares  which the  Warrantholder  is
entitled  to  purchase  is  subject to  adjustment  upon the  occurrence  of the
contingencies set forth in Section 3 of this Warrant,  and as adjusted from time
to time, such purchase price is hereinafter referred to as the "Warrant Price."

                  This Warrant is subject to the following terms and conditions:

           1.     EXERCISE OF WARRANT.

                  (1)      This Warrant may be exercised in whole or in part but
                           not for a  fractional  share.  Upon  delivery of this
                           Warrant  at the  offices  of the  Company  or at such
                           other  address as the Company may designate by notice
                           in writing to the  registered  holder hereof with the
                           Subscription   Form  annexed  hereto  duly  executed,
                           accompanied  by payment of the Warrant  Price for the
                           number of Warrant Shares



<PAGE>



                           purchased (in cash, by certified,  cashier's or other
                           check  acceptable to the Company,  by Common Stock of
                           the  Company  having a Market  Value (as  hereinafter
                           defined) equal to the aggregate Warrant Price for the
                           Warrant Shares to be purchased, or any combination of
                           the foregoing), the registered holder of this Warrant
                           shall  be  entitled  to  receive  a  certificate   or
                           certificates  for the  Warrant  Shares so  purchased.
                           Such  certificate or  certificates  shall be promptly
                           delivered  to the  Warrantholder.  Upon  any  partial
                           exercise of this  Warrant,  the Company shall execute
                           and  deliver  a new  Warrant  of like  tenor  for the
                           balance of the Warrant Shares purchasable hereunder.

                  (2)      In  lieu  of  exercising  this  Warrant  pursuant  to
                           Section 1(1),  the holder may elect to receive shares
                           of Common  Stock  equal to the value of this  Warrant
                           determined  in the  manner  described  below  (or any
                           portion thereof remaining  unexercised) upon delivery
                           of this  Warrant at the  offices of the Company or at
                           such other  address as the Company may  designate  by
                           notice in writing  to the  registered  holder  hereof
                           with the Notice of  Cashless  Exercise  Form  annexed
                           hereto duly executed. In such event the Company shall
                           issue  to  the  holder  a  number  of  shares  of the
                           Company's  Common Stock  computed using the following
                           formula:

                                   X = Y (A-B)
                                       -------
                                        A


Where    X = the number of shares of Common Stock to be issued to the holder.
         Y = the number of shares of Common Stock purchasable under this Warrant
             (at the date of such calculation).
         A = the Market Value of the Company's  Common Stock on the business day
             immediately  preceding  the day on which  the  Notice  of  Cashless
             Exercise is received by the Company.
         B = Warrant Price (as adjusted to the date of such calculation).


                  (3)      The Warrant Shares deliverable  hereunder shall, upon
                           issuance,  be fully paid and  non-assessable  and the
                           Company  agrees that at all times  during the term of
                           this  Warrant  it  shall  cause  to be  reserved  for
                           issuance such number of shares of its Common Stock as
                           shall be required  for  issuance  and  delivery  upon
                           exercise of this Warrant.

                  (4)      For purposes of this  Warrant,  the Market Value of a
                           share of Common  Stock on any date  shall be equal to
                           (i) the closing  sale price per share as published by
                           a national  securities  exchange  on which  shares of
                           Common  Stock (or other  units of the  security)  are
                           traded (an  "Exchange")  on such date or, if there is
                           no sale of Common Stock on such date,  the average of
                           the bid and asked



<PAGE>



                           prices on such  exchange  at the close of  trading on
                           such date or, (ii) if shares of Common  Stock are not
                           listed  on a  national  securities  exchange  on such
                           date, the closing price per share as published on the
                           National  Association of Securities Dealers Automatic
                           Quotation System ("NASDAQ") National Market System if
                           the shares are quoted on such system on such date, or
                           (iii) the average of the bid and asked  prices in the
                           over-the-counter  market at the close of  trading  on
                           such date if the shares are not traded on an exchange
                           or listed on the NASDAQ  National  Market System,  or
                           (iv) if the Common  Stock is not traded on a national
                           securities   exchange  or  in  the   over-the-counter
                           market,  the fair  market  value of a share of Common
                           Stock on such date as determined in good faith by the
                           Board of Directors.  If the holder disagrees with the
                           determination  of the Market Value of any  securities
                           of the Company  determined  by the Board of Directors
                           under  Section  1(4)(iv)  the  Market  Value  of such
                           securities  shall  be  determined  by an  independent
                           appraiser  acceptable  to the  Company and the holder
                           (or, if they cannot agree on such an appraiser, by an
                           independent  appraiser  selected by each of them, and
                           Market  Value  shall be the median of the  appraisals
                           made by such appraisers).  If there is one appraiser,
                           the cost of the  appraisal  shall be  shared  equally
                           between the Company and the holder.  If there are two
                           appraisers,  each of the Company and the holder shall
                           pay for its own appraisal.

         2.       TRANSFER OR ASSIGNMENT OF WARRANT.

                  (1)      Any  assignment  or transfer of this Warrant shall be
                           made by  surrender  of this Warrant at the offices of
                           the  Company or at such other  address as the Company
                           may  designate  in writing to the  registered  holder
                           hereof with the  Assignment  Form annexed hereto duly
                           executed and  accompanied by payment of any requisite
                           transfer  taxes,  and  the  Company  shall,   without
                           charge,  execute  and  deliver a new  Warrant of like
                           tenor in the name of the  assignee for the portion so
                           assigned in case of only a partial assignment, with a
                           new  Warrant  of like tenor to the  assignor  for the
                           balance of the Warrant Shares purchasable.

                  (2)      Prior to any  assignment or transfer of this Warrant,
                           the  holder  thereof  shall  deliver  an  opinion  of
                           counsel  to  the  Company  to  the  effect  that  the
                           proposed    transfer   may   be   effected    without
                           registration under the Act.

          3.       ADJUSTMENT OF WARRANT PRICE AND WARRANT SHARES -- 
                   ANTI-DILUTION PROVISIONS.

                           A. (1) Except as  hereinafter  provided,  in case the
                  Company  shall at any time  after  the date  hereof  issue any
                  shares of Common Stock


<PAGE>


                  (including  shares  held in the  Company's  treasury)  without
                  consideration,  then,  and thereafter  successively  upon each
                  issuance,  the Warrant  Price in effect  immediately  prior to
                  each such  issuance  shall  forthwith  be  reduced  to a price
                  determined  by   multiplying   the  Warrant  Price  in  effect
                  immediately prior to such issuance by a fraction:

                           (a)      the  numerator  of which  shall be the total
                                    number of shares of Common Stock outstanding
                                    immediately prior to such issuance, and

                           (b)      the  denominator of which shall be the total
                                    number of shares of Common Stock outstanding
                                    immediately after such issuance.

                  For the purposes of any  computation  to be made in accordance
with the  provisions  of this  clause (1),  the  following  provisions  shall be
applicable:

                                    (i)      Shares of Common Stock  issuable by
                                             way   of    dividend    or    other
                                             distribution  on any  stock  of the
                                             Company  shall  be  deemed  to have
                                             been  issued and to be  outstanding
                                             at the  close  of  business  on the
                                             record    date    fixed   for   the
                                             determination    of    stockholders
                                             entitled to receive  such  dividend
                                             or other  distribution and shall be
                                             deemed to have been issued  without
                                             consideration.   Shares  of  Common
                                             Stock  issued  otherwise  than as a
                                             dividend,  shall be  deemed to have
                                             been  issued and to be  outstanding
                                             at the  close  of  business  on the
                                             date of issue.

                                    (ii)     The  number  of  shares  of  Common
                                             Stock at any time outstanding shall
                                             not  include  any shares then owned
                                             or held by or for  the  account  of
                                             the Company.

                                    (2) In case  the  Company  shall at any time
                           subdivide or combine the outstanding shares of Common
                           Stock,   the  Warrant   Price  shall   forthwith   be
                           proportionately   decreased   in  the   case  of  the
                           subdivision or proportionately  increased in the case
                           of  combination  to the  nearest  one cent.  Any such
                           adjustment  shall  become  effective  at the close of
                           business  on  the  date  that  such   subdivision  or
                           combination shall become effective.

                           B. In the event that the number of outstanding shares
                  of Common Stock is increased  by a stock  dividend  payable in
                  shares of Common Stock or by a subdivision of the  outstanding
                  shares of Common Stock,  which may include a stock split, then
                  from and after the time at which the  adjusted  Warrant  Price
                  becomes


<PAGE>


                  effective  pursuant  to the  foregoing  Subsection  A of  this
                  Section by reason of such dividend or subdivision,  the number
                  of shares  issuable upon the exercise of this Warrant shall be
                  increased  in  proportion  to  such  increase  in  outstanding
                  shares. In the event that the number of outstanding  shares of
                  Common Stock is decreased by a combination of the  outstanding
                  shares of Common Stock, then, from and after the time at which
                  the adjusted Warrant Price becomes effective  pursuant to such
                  Subsection  A of this  Section by reason of such  combination,
                  the  number  of  shares  issuable  upon the  exercise  of this
                  Warrant  shall be decreased in  proportion to such decrease in
                  outstanding shares.

                           C.  In the  event  of an  adjustment  of the  Warrant
                  Price,  the number of shares of Common Stock (or  reclassified
                  stock)  issuable  upon  exercise  of this  Warrant  after such
                  adjustment  shall  be  equal  to  the  number   determined  by
                  dividing:

                                    (1)      an amount  equal to the  product of
                                             (i) the  number of shares of Common
                                             Stock  issuable  upon  exercise  of
                                             this Warrant  immediately  prior to
                                             such   adjustment,   and  (ii)  the
                                             Warrant Price  immediately prior to
                                             such adjustment, by

                                    (2)      the Warrant Price immediately after
                                             such adjustment.

                           D.   In   the   case   of   any   reorganization   or
                  reclassification  of the  outstanding  shares of Common  Stock
                  (other than a change in par value, or from par value to no par
                  value,  or from no par value to par value, or as a result of a
                  subdivision   or   combination)   or  in  the   case   of  any
                  consolidation  of the Company  with,  or merger of the Company
                  with, another  corporation,  or in the case of any sale, lease
                  or conveyance of all, or  substantially  all, of the property,
                  assets, business and goodwill of the Company as an entity, the
                  holder of this Warrant  shall  thereafter  have the right upon
                  exercise  to  purchase  the kind and amount of shares of stock
                  and  other  securities  and  property   receivable  upon  such
                  reorganization,  reclassification,  consolidation,  merger  or
                  sale by a holder of the number of shares of Common Stock which
                  the holder of this Warrant would have received had all Warrant
                  Shares  issuable  upon  exercise of this  Warrant  been issued
                  immediately  prior to such  reorganization,  reclassification,
                  consolidation, merger or sale, at a price equal to the Warrant
                  Price then in effect  pertaining  to this  Warrant  (the kind,
                  amount  and price of such  stock and  other  securities  to be
                  subject to adjustment as herein provided).

                           E. In case the  Company  shall,  at any time prior to
                  the  expiration  of this  Warrant  and  prior to the  exercise
                  thereof,  dissolve,  liquidate  or  wind up its  affairs,  the
                  Warrantholder shall be entitled, upon the exercise thereof, to
                  receive, in lieu of the Warrant Shares of the Company which it
                  would have been entitled to receive,  the same kind and amount
                  of assets as would have been issued, distributed or paid to it
                  upon  such  Warrant  Shares  of the  Company,  had it been the
                  holder of


<PAGE>


                  record of shares of Common Stock  receivable upon the exercise
                  of this  Warrant on the record date for the  determination  of
                  those entitled to receive any such  liquidating  distribution.
                  After any such  dissolution,  liquidation  or winding up which
                  shall  result in any  distribution  in  excess of the  Warrant
                  Price provided for by this Warrant,  the  Warrantholder may at
                  its option  exercise  the same without  making  payment of the
                  aggregate  Warrant  Price and in such case the  Company  shall
                  upon the distribution to said Warrantholder  consider that the
                  aggregate  Warrant  Price  has been  paid in full to it and in
                  making settlement to said Warrantholder, shall deduct from the
                  amount  payable to such  Warrantholder  an amount equal to the
                  aggregate Warrant Price.

                           F. In case the  Company  shall,  at any time prior to
                  the  expiration  of this  Warrant  and  prior to the  exercise
                  thereof  make a  distribution  of assets  (other than cash) or
                  securities   of  the   Company   to  its   stockholders   (the
                  "Distribution") the Warrantholder shall be entitled,  upon the
                  exercise  thereof,  to  receive,  in  addition  to the Warrant
                  Shares it is entitled to receive,  the same kind and amount of
                  assets or securities as would have been  distributed  to it in
                  the Distribution had it been the holder of record of shares of
                  Common Stock  receivable  upon exercise of this Warrant on the
                  record date for determination of those entitled to receive the
                  Distribution.

                           G.  Irrespective  of any adjustments in the number of
                  Warrant  Shares and the Warrant Price or the number or kind of
                  shares purchasable upon exercise of this Warrant, this Warrant
                  may  continue to express the same price and number and kind of
                  shares as originally issued.

                  4.  OFFICER'S  CERTIFICATE.  Whenever  the  number of  Warrant
Shares and the  Warrant  Price  shall be  adjusted  pursuant  to the  provisions
hereof,  the Company shall forthwith file, at its principal  executive  office a
statement,  signed by the Chairman of the Board,  President,  or one of the Vice
Presidents  of the  Company  and by its Chief  Financial  Officer  or one of its
Treasurers  or  Assistant  Treasurers,  stating the  adjusted  number of Warrant
Shares and the new Warrant  Price  calculated  to the nearest one  hundredth and
setting  forth in  reasonable  detail  the method of  calculation  and the facts
requiring  such  adjustment  and upon  which  such  calculation  is based.  Each
adjustment  shall remain in effect until a  subsequent  adjustment  hereunder is
required.
A copy of such statement shall be mailed to the Warrantholder.

                  5. CHARGES,  TAXES AND EXPENSES.  The issuance of certificates
for Warrant  Shares  upon any  exercise of this  Warrant  shall be made  without
charge to the  Warrantholder  for any tax or other  expense  in  respect  to the
issuance of such certificates,  all of which taxes and expenses shall be paid by
the  Company,  and such  certificates  shall be  issued  only in the name of the
Warrantholder.


<PAGE>


                  6.       MISCELLANEOUS.

                                    (1) The  terms  of  this  Warrant  shall  be
                           binding  upon and shall  inure to the  benefit of any
                           successors  or  assigns  of  the  Company  and of the
                           holder or holders  hereof and of the shares of Common
                           Stock issued or issuable upon the exercise hereof.

                                    (2) No  holder  of this  Warrant,  as  such,
                           shall be entitled to vote or receive  dividends or be
                           deemed to be a  stockholder  of the  Company  for any
                           purpose, nor shall anything contained in this Warrant
                           be  construed  to  confer  upon  the  holder  of this
                           Warrant,  as such, any rights of a stockholder of the
                           Company  or any  right  to  vote,  give  or  withhold
                           consent to any corporate  action,  receive  notice of
                           meetings,  receive dividends or subscription  rights,
                           or otherwise.

                                    (3)  Receipt  of this  Warrant by the holder
                           hereof shall constitute acceptance of an agreement to
                           the foregoing terms and conditions.

                                    (4) The Warrant and the  performance  of the
                           parties  hereunder shall be construed and interpreted
                           in accordance  with the laws of the State of New York
                           and the parties  hereunder consent and agree that the
                           State and  Federal  Courts  which sit in the State of
                           New  York  and the  County  of New  York  shall  have
                           exclusive    jurisdiction   with   respect   to   all
                           controversies and disputes arising hereunder.

                                    (5)  Shares  issued  upon  exercise  of this
                           Warrant shall be legended substantially as follows:

         "The  shares  evidenced  by this  certificate  have  not  been
         registered  under the Securities Act of 1933, as amended,  and
         must be held indefinitely unless they are transferred pursuant
         to an effective registration statement under that Act or after
         receipt of an opinion of counsel  satisfactory  to the Company
         that registration is not required."

                  IN WITNESS WHEREOF,  the Company has caused this Warrant to be
signed by its duly  authorized  officer  and its  corporate  seal to be  affixed
hereto.

Dated: November 16, 1998

                                  ADVANCED VIRAL RESEARCH CORP.


                                  BY: \s\ Shalom Hirschman 
                                       Shalom Hirschman, M.D., President


<PAGE>


                                SUBSCRIPTION FORM


                    (TO BE EXECUTED BY THE REGISTERED HOLDER
                     IF HE DESIRES TO EXERCISE THE WARRANT)


         To:      ADVANCED VIRAL RESEARCH CORP.


                  The  undersigned   hereby  exercises  the  right  to  purchase
_________  shares of Common Stock,  par value $.00001 per share,  covered by the
attached  Warrant  in  accordance  with the terms and  conditions  thereof,  and
herewith makes payment of the Warrant Price for such shares in full.


                                    -------------------------------------------
                                    SIGNATURE


                                    --------------------------------------------
                                    ADDRESS

                                    --------------------------------------------



DATED:
      --------------------


<PAGE>


                   NOTICE OF EXERCISE OF COMMON STOCK WARRANT
             PURSUANT TO NET ISSUE ("CASHLESS") EXERCISE PROVISIONS


                                                                        , 199   
                                                            ------------     ---


Advanced Viral Research Corp.        Aggregate Price of          $
a Delaware corporation               of Warrant                   --------------
200 Corporate Boulevard South
Yonkers, New York 10701              Aggregate Price Being
                                     Exercised:                  $
Attention:                                                        --------------
          --------------------       Warrant Price
                                     (per share):                $
                                     Number of Shares of          --------------
                                     Common Stock to be
                                     Issued Under this
                                     Notice:



                                CASHLESS EXERCISE


Gentlemen:

                  The undersigned,  registered holder of the Warrant to Purchase
Common Stock delivered herewith  ("Warrant")  hereby irrevocably  exercises such
Warrant for, and  purchases  thereunder,  shares of the Common Stock of ADVANCED
VIRAL RESEARCH CORP., a Delaware  corporation,  as provided  below.  Capitalized
terms used herein,  unless  otherwise  defined  herein,  shall have the meanings
given in the  Warrant.  The  portion  of the  Aggregate  Price  (as  hereinafter
defined)  to be applied  toward the  purchase of Common  Stock  pursuant to this
Notice of Exercise is $ , thereby  leaving a remainder  Aggregate Price (if any)
equal to $
        . Such exercise shall be pursuant to the net issue  exercise  provisions
of Section 1(b) of the Warrant; therefore, the holder makes no payment with this
Notice of Exercise.  The number of shares to be issued pursuant to this exercise
shall be  determined  by reference to the formula in Section 1(b) of the Warrant
which  requires  the use of the Market  Value (as defined in Section 1(d) of the
Warrant) of the Company's Common Stock on the business day immediately preceding
the day on which  this  Notice is  received  by the  Company.  To the extent the
foregoing exercise is for less than the full Aggregate Price of the Warrant, the
remainder of the Warrant  representing  a number of Shares equal to the quotient
obtained by dividing the remainder of the  Aggregate  Price by the Warrant Price
(and otherwise of like form, tenor and effect) may be exercised under Section


<PAGE>


1(a) of the  Warrant.  For  purposes of this Notice the term  "Aggregate  Price"
means the product  obtained by multiplying  the number of shares of Common Stock
for which the Warrant is exercisable times the Warrant Price.


                                    -------------------------------------------
                                    SIGNATURE

DATE:
     --------------------           --------------------------------------------
                                    ADDRESS


                                        2

<PAGE>


                                   ASSIGNMENT


                    (To be Executed by the Registered Holder
                     if he Desires to Transfer the Warrant)


                  FOR VALUE RECEIVED,  the undersigned hereby sells, assigns and
transfers  unto                          the right to purchase  shares of Common
Stock of ADVANCED VIRAL RESEARCH  CORP.,  evidenced by the within  Warrant,  and
does hereby irrevocably constitute and appoint                          Attorney
to transfer  the said  Warrant on the books of the  Company,  with full power of
substitution.


                                    -------------------------------------------
                                    SIGNATURE


                                    --------------------------------------------
                                    ADDRESS

DATED:
      ---------------------

IN THE PRESENCE OF:


- ---------------------------





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