<TABLE> <S> <C>
<ARTICLE> 6
<LEGEND>
THIS SCHEDULE CONTAINS SUMMARY FINANCIAL INFORMATION EXTRACTED FROM THE
STATEMENT OF ASSETS AND LIABILITIES, STATEMENT OF OPERATIONS AND STATE-
MENT OF CHANGES IN NET ASSETS FOUND ON PAGES 108 THROUGH 132 OF THE FORTIS
SERIES FUND, INC. SEMI-ANNUAL SHAREHOLDER REPORT.
</LEGEND>
<CIK> 0000790558
<NAME> FORTIS SERIES FUND, INC.
<SERIES>
<NUMBER> 21
<NAME> CAPITAL OPPORTUNITIES SERIES
<MULTIPLIER> 1
<S> <C>
<PERIOD-TYPE> 2-MOS
<FISCAL-YEAR-END> DEC-31-2000
<PERIOD-START> MAY-01-2000
<PERIOD-END> JUN-30-2000
<INVESTMENTS-AT-COST> 8,827,276
<INVESTMENTS-AT-VALUE> 9,172,559
<RECEIVABLES> 73,219
<ASSETS-OTHER> 0
<OTHER-ITEMS-ASSETS> 2,762
<TOTAL-ASSETS> 9,248,540
<PAYABLE-FOR-SECURITIES> 46,595
<SENIOR-LONG-TERM-DEBT> 0
<OTHER-ITEMS-LIABILITIES> 9,175
<TOTAL-LIABILITIES> 55,770
<SENIOR-EQUITY> 0
<PAID-IN-CAPITAL-COMMON> 8,826,114
<SHARES-COMMON-STOCK> 875,941
<SHARES-COMMON-PRIOR> 0
<ACCUMULATED-NII-CURRENT> 8,142
<OVERDISTRIBUTION-NII> 0
<ACCUMULATED-NET-GAINS> 13,191
<OVERDISTRIBUTION-GAINS> 0
<ACCUM-APPREC-OR-DEPREC> 345,323
<NET-ASSETS> 9,192,770
<DIVIDEND-INCOME> 7,482
<INTEREST-INCOME> 19,374
<OTHER-INCOME> 0
<EXPENSES-NET> (20,208)
<NET-INVESTMENT-INCOME> 6,648
<REALIZED-GAINS-CURRENT> 14,685
<APPREC-INCREASE-CURRENT> 345,323
<NET-CHANGE-FROM-OPS> 366,656
<EQUALIZATION> 0
<DISTRIBUTIONS-OF-INCOME> 0
<DISTRIBUTIONS-OF-GAINS> 0
<DISTRIBUTIONS-OTHER> 0
<NUMBER-OF-SHARES-SOLD> 876,596
<NUMBER-OF-SHARES-REDEEMED> (655)
<SHARES-REINVESTED> 0
<NET-CHANGE-IN-ASSETS> 9,192,770
<ACCUMULATED-NII-PRIOR> 0
<ACCUMULATED-GAINS-PRIOR> 0
<OVERDISTRIB-NII-PRIOR> 0
<OVERDIST-NET-GAINS-PRIOR> 0
<GROSS-ADVISORY-FEES> 14,254
<INTEREST-EXPENSE> 0
<GROSS-EXPENSE> 21,193
<AVERAGE-NET-ASSETS> 8,099,881
<PER-SHARE-NAV-BEGIN> 10.61
<PER-SHARE-NII> 0
<PER-SHARE-GAIN-APPREC> (0.12)
<PER-SHARE-DIVIDEND> 0
<PER-SHARE-DISTRIBUTIONS> 0
<RETURNS-OF-CAPITAL> 0
<PER-SHARE-NAV-END> 10.49
<EXPENSE-RATIO> 1.25<F1><F2>
<FN>
<F1>ANNUALIZED.
<F2>FORTIS ADVISERS HAS VOLUNTARILY UNDERTAKEN TO LIMIT ANNUAL EXPENSES FOR
CAPITAL OPPORTUNITIES SERIES (EXCLUSIVE OF INTEREST, TAXES, BROKERAGE COMM-
ISSION AND NON-RECURRING EXTRAORDINARY CHARGES AND EXPENSES) TO 1.25% OF
AVERAGE NET ASSETS. FOR THE PERIOD, HAD THE WAIVER AND REIMBURSMENT OF
EXPENSES NOT BEEN IN EFFECT, THE RATIO OF EXPENSES TO AVERAGE DAILY NET
WOULD HAVE BEEN 1.33%.
</FN>
</TABLE>
