ADVANCED MAGNETICS INC
SC 13G/A, 1999-02-04
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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<PAGE>   1


                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  SCHEDULE 13G
                                 (RULE 13d-102)
             INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
           TO RULES 13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED
                              PURSUANT TO 13d-2(b)

                             (AMENDMENT NO.    11    )[1]
                                           ----------


                            ADVANCED MAGNETICS, INC.
- --------------------------------------------------------------------------------
                                (Name of Issuer)

                                  COMMON STOCK
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                   00753P 10 3
- --------------------------------------------------------------------------------
                                 (CUSIP Number)

- --------------------------------------------------------------------------------
             (Date of Event Which Requires Filing of This Statement)


Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

[ ] Rule 13d - 1(b)
[ ] Rule 13d - 1(c) 
[X] Rule 13d - 1(d)







- --------
1 The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).


<PAGE>   2

- ----------------------------                  ----------------------------

CUSIP NO.  00753P 10 3             13G         Page   2   of    6   Pages
         ---------------                            -----     -----
- ----------------------------                  ----------------------------


- --------------------------------------------------------------------------------
   1     NAME OF REPORTING PERSONS

         I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

         Marlene Kaplan Goldstein

- --------------------------------------------------------------------------------
   2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

                                                               (a) [ ]
                                                               (b) [ ]

- --------------------------------------------------------------------------------
   3     SEC USE ONLY


- --------------------------------------------------------------------------------
   4     CITIZENSHIP OR PLACE OF ORGANIZATION

         No Change


- --------------------------------------------------------------------------------
                                5    SOLE VOTING POWER
                                            644,837
        
         NUMBER OF            --------------------------------------------------
           SHARES               6    SHARED VOTING POWER
        BENEFICIALLY                         59,400
          OWNED BY
            EACH              --------------------------------------------------
          REPORTING             7    SOLE DISPOSITIVE POWER
           PERSON                           644,837
            WITH    
                              --------------------------------------------------
                                8    SHARED DISPOSITIVE POWER
                                             59,400

- --------------------------------------------------------------------------------
    9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                 704,237

- --------------------------------------------------------------------------------
   10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN    [X]
          SHARES*
                 See Item 4(a)

- --------------------------------------------------------------------------------
   11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                   10.4%

- --------------------------------------------------------------------------------
   12     TYPE OF REPORTING PERSON *

                 No Change

- --------------------------------------------------------------------------------

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>   3


ITEM 1 (a).  NAME OF ISSUER:
- -----------  ---------------

             Advanced Magnetics, Inc.

ITEM 1 (b).  ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES:
- -----------  ------------------------------------------------

             61 Mooney Street
             Cambridge, MA  02138

ITEM 2 (a).  NAME OF PERSON FILING:
- -----------  ----------------------

             Marlene Kaplan Goldstein

ITEM 2 (b).  ADDRESS OF PRINCIPAL BUSINESS OFFICE OR, IF NONE, RESIDENCE:
- -----------  ------------------------------------------------------------

             c/o Advanced Magnetics, Inc.
             61 Mooney Street
             Cambridge, MA  02138

ITEM 2 (c).  CITIZENSHIP:
- -----------  ------------

             United States

ITEM 2 (d).  TITLE OF CLASS OF SECURITIES:
- -----------  -----------------------------

             Common Stock, $.01 Par Value Per Share

ITEM 2 (e).  CUSIP NUMBER
- -----------  ------------
             00753P 10 3

ITEM 3.      IF THIS STATEMENT IS FILED PURSUANT TO RULE 13d-1(b), OR 13d-2(b)
- -------      -----------------------------------------------------------------
             OR (c), CHECK WHETHER THE FILING PERSON IS A:
             ---------------------------------------------

             (a) [ ] Broker or dealer registered under Section 15 of the
                     Exchange Act.

             (b) [ ] Bank as defined in Section 3(a)(6) of the Exchange Act.

             (c) [ ] Insurance company as defined in Section 3(a)(19) of the 
                     Exchange Act.

             (d) [ ] Investment company registered under Section 8 of the 
                     Investment Company Act.

             (e) [ ] An investment adviser in accordance with 
                     Rule 13d-1(b)(1)(ii)(E);

             (f) [ ] An employee benefit plan or endowment fund in accordance 
                     with Rule 13d-1(b)(1)(ii)(F);

             (g) [ ] A parent holding company or control person in accordance 
                     with Rule 13d-1(b)(1)(ii)(G);


                               Page 3 of 6 pages


<PAGE>   4


             (h) [ ] A savings association as defined in Section 3(b) of the 
                     Federal Deposit Insurance Act;

             (i) [ ] A church plan that is excluded from the definition of an 
                     investment company under Section 3(c)(14) of the
                     Investment Company Act;

             (j) [ ] Group, in accordance with Rule 13d-1(b)(1)(ii)(J).

             If this statement is filed pursuant to Rule 13d-1(c), 
             check this box. [ ]

ITEM 4.      OWNERSHIP:
- -------      ----------

             (a)        Amount Beneficially Owned:
             
                        704,237.  This amount does not include 644,959 shares 
                        owned by spouse, as to which shares beneficial ownership
                        is disclaimed.

             (b)        Percent of Class:

                        10.4 % (based on 6,767,509 shares of Common Stock 
                        reported by the Company's transfer agent as outstanding 
                        at the close of business on December 31, 1998).

             (c)        Number of shares as to which such person has: 

                        (i)       Sole power to vote or direct the vote 644,837.

                        (ii)      Shared power to vote or to direct the vote 
                                  59,400.

                        (iii)     Sole power to dispose or to
                                  direct the disposition of
                                  644,837.

                        (iv)      Shared power to dispose or
                                  to direct the disposition of
                                  59,400.

ITEM 5.      OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS:

                       Inapplicable.

ITEM 6.      OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON:

                       Inapplicable.

ITEM 7.      IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED 
             THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY:

                       Inapplicable.

ITEM 8.      IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP:

                       Inapplicable.


                               Page 4 of 6 pages


<PAGE>   5


ITEM 9.      NOTICE OF DISSOLUTION OF GROUP:

                       Inapplicable.

ITEM 10.     CERTIFICATION:

                       Inapplicable.


<PAGE>   6



                                    SIGNATURE

     After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

                                       January 29, 1999                         
                                       -----------------------------------------
                                                Date

                                       /s/ Marlene Kaplan Goldstein             
                                       -----------------------------------------
                                                Signature

                                       Marlene Kaplan Goldstein/Secretary     
                                       -----------------------------------------
                                                Name/Title





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