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SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, DC 20549
SCHEDULE 13G
(RULE 13b-102)
INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
TO RULES 13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED
PURSUANT TO 13d-2
(AMENDMENT NO.)(1)
ADVANCED MAGNETICS, INC.
(Name of Issuer)
COMMON STOCK
(Title of Class of Securities)
00753P 10 3
(CUSIP Number)
DECEMBER 28, 1999
(Date of Event Which Requires Filing of this Statement)
Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:
/ / Rule 13d-1(b)
/X/ Rule 13d-1(c)
/ / Rule 13d-1(d)
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(1) The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter disclosures provided in a prior cover page.
The information required on the remainder of this cover page shall not
be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, SEE the
NOTES).
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CUSIP NO. 00753P 10 3 13G PAGE 2 OF 8 PAGES
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1 NAME OF REPORTING PERSON:
BIOTECHNOLOGY VALUE FUND, L.P.
I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):
- --------------------------------------------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) /X/ (b) / /
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3 SEC USE ONLY
- --------------------------------------------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
DELAWARE
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NUMBER 5 SOLE VOTING POWER
OF 0
SHARES ------------------------------------------------------------------------------------------
BENEFICIALLY 6 SHARED VOTING POWER
OWNED BY EACH 385,413
REPORTING ------------------------------------------------------------------------------------------
PERSON 7 SOLE DISPOSITIVE POWER
WITH 0
------------------------------------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
385,413
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9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
385,413
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10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
CERTAIN SHARES* / /
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11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
5.7%
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12 TYPE OF REPORTING PERSON*
PN
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</TABLE>
* SEE INSTRUCTIONS BEFORE FILLING OUT!
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CUSIP NO. 00753P 10 3 13G PAGE 3 OF 8 PAGES
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1 NAME OF REPORTING PERSON:
BIOTECHNOLOGY VALUE FUND II, L.P.
I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):
- --------------------------------------------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) /X/ (b) / /
- --------------------------------------------------------------------------------------------------------------------
3 SEC USE ONLY
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4 CITIZENSHIP OR PLACE OF ORGANIZATION
DELAWARE
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NUMBER 5 SOLE VOTING POWER
OF 0
SHARES ------------------------------------------------------------------------------------------
BENEFICIALLY 6 SHARED VOTING POWER
OWNED BY EACH 394,257
REPORTING ------------------------------------------------------------------------------------------
PERSON 7 SOLE DISPOSITIVE POWER
WITH 0
------------------------------------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
394,257
- --------------------------------------------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
394,257
- --------------------------------------------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
CERTAIN SHARES* / /
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11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
5.8%
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12 TYPE OF REPORTING PERSON*
PN
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</TABLE>
* SEE INSTRUCTIONS BEFORE FILLING OUT!
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CUSIP NO. 00753P 10 3 13G PAGE 4 OF 8 PAGES
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1 NAME OF REPORTING PERSON:
BVF PARTNERS L.P.
I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):
- --------------------------------------------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) /X/ (b) / /
- --------------------------------------------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
DELAWARE
- --------------------------------------------------------------------------------------------------------------------
NUMBER 5 SOLE VOTING POWER
OF 0
SHARES ------------------------------------------------------------------------------------------
BENEFICIALLY 6 SHARED VOTING POWER
OWNED BY EACH 796,050
REPORTING ------------------------------------------------------------------------------------------
PERSON 7 SOLE DISPOSITIVE POWER
WITH 0
------------------------------------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
796,050
- --------------------------------------------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
796,050
- --------------------------------------------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
CERTAIN SHARES* / /
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11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
11.8%
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12 TYPE OF REPORTING PERSON*
PN
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</TABLE>
* SEE INSTRUCTIONS BEFORE FILLING OUT!
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<TABLE>
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CUSIP NO. 00753P 10 3 13G PAGE 5 OF 8 PAGES
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1 NAME OF REPORTING PERSON:
BVF INC.
I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):
- --------------------------------------------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) /X/ (b) / /
- --------------------------------------------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
DELAWARE
- --------------------------------------------------------------------------------------------------------------------
NUMBER 5 SOLE VOTING POWER
OF 0
SHARES ------------------------------------------------------------------------------------------
BENEFICIALLY 6 SHARED VOTING POWER
OWNED BY EACH 796,050
REPORTING ------------------------------------------------------------------------------------------
PERSON 7 SOLE DISPOSITIVE POWER
WITH 0
------------------------------------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
796,050
- --------------------------------------------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
796,050
- --------------------------------------------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
CERTAIN SHARES* / /
- --------------------------------------------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
11.8%
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12 TYPE OF REPORTING PERSON*
IA, CO
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</TABLE>
* SEE INSTRUCTIONS BEFORE FILLING OUT!
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CUSIP NO. 00753P 10 3 13G PAGE 6 OF 8 PAGES
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ITEM 1(a). NAME OF ISSUER:
Advanced Magnetics, Inc. ("Advanced Magnetics")
ITEM 1(b). ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES:
61 Mooney Street
Cambridge, MA 02138-1038
ITEM 2(a). NAME OF PERSON FILING:
This Schedule 13G is being filed on behalf of the following
persons*:
(i) Biotechnology Value Fund, L.P. ("BVF")
(ii) Biotechnology Value Fund II, L.P. ("BVF2")
(iii) BVF Partners, L.P. ("Partners")
(iv) BVF Inc. ("BVF Inc.")
* Attached as Exhibit A is a copy of an agreement
between the Persons filing (as specified hereinabove)
that this Schedule 13G is being filed on behalf of
each of them.
ITEM 2(b). ADDRESS OF PRINCIPAL BUSINESS OFFICE:
The principal business office of the persons comprising the
group filing this Schedule 13G is located at 227 West Monroe Street, Suite 4800,
Chicago, Illinois 60606.
ITEM 2(c). CITIZENSHIP:
BVF: a Delaware limited partnership
BVF2: a Delaware limited partnership
Partners: a Delaware limited partnership
BVF Inc.: a Delaware corporation
ITEM 2(d). TITLE OF CLASS OF SECURITIES:
The class of securities beneficially owned by the persons
filing this statement is common stock.
ITEM 2(e). CUSIP NUMBER:
00753P 10 3
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CUSIP NO. 00753P 10 3 13G PAGE 7 OF 8 PAGES
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ITEM 3. IF THIS STATEMENT IS FILED PURSUANT TO RULE 13d-1(c), CHECK
THIS BOX: /X/
ITEM 4. OWNERSHIP:
The information in items 1 and 5 through 11 on the cover pages
(pp.2 - 5) on Schedule 13G is hereby incorporated by reference.
ITEM 5. OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS:
If this statement is being filed to report the fact that as of
the date hereof the reporting person has ceased to be the beneficial owner of
more than five percent of the class of securities check the following. / /
ITEM 6. OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER
PERSON:
BVF shares voting and dispositive power over the shares of the
Stock it beneficially owns with Partners. BVF2 also shares voting and
dispositive power over the shares of the Stock it beneficially owns with
Partners. Partners and BVF Inc. share voting and dispositive power over the
shares of the Stock they beneficially own with, in addition to BVF and BVF2,
certain managed accounts on whose behalf Partners, as investment manager,
purchased such shares. BVF Inc. also shares voting and dispositive power over
the shares of the Stock they beneficially own with, in addition to BVF, BVF2 and
Partners, certain other managed accounts on whose behalf BVF Inc., as investment
manager, purchased such shares. None of the managed accounts individually own
more than 5% of the Stock of the Issuer.
ITEM 7. IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH
ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING
COMPANY:
Not applicable.
ITEM 8. IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF A GROUP:
Not applicable.
ITEM 9. NOTICE OF DISSOLUTION OF GROUP:
Not applicable.
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CUSIP NO. 00753P 10 3 13G PAGE 8 OF 8 PAGES
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ITEM 10. CERTIFICATION
By signing below I certify that, to the best of my knowledge
and belief, the securities referred to above were not acquired and are not held
for the purpose of or with the effect of changing or influencing the control of
the issuer of the securities and were not acquired and are not held in
connection with or as a participant in any transaction having that purpose or
effect.
After reasonable inquiry and to the best of my knowledge
and belief, I certify that the information set forth in this Schedule 13G is
true, complete and correct.
Dated: January 7, 2000
BIOTECHNOLOGY VALUE FUND, L.P.
By: BVF Partners L.P., its general partner
By: BVF Inc., its general partner
By: /s/ Mark N. Lampert
--------------------------
Mark N. Lampert
President
BIOTECHNOLOGY VALUE FUND II, L.P.
By: BVF Partners L.P., its general partner
By: BVF Inc., its general partner
By: /s/ Mark N. Lampert
--------------------------
Mark N. Lampert
President
BVF PARTNERS L.P.
By: BVF Inc., its general partner
By: /s/ Mark N. Lampert
--------------------------
Mark N. Lampert
President
BVF INC.
By: /s/ Mark N. Lampert
--------------------------
Mark N. Lampert
President
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EXHIBIT A
AGREEMENT REGARDING JOINT FILING
The undersigned, Biotechnology Value Fund, L.P., a Delaware
limited partnership, Biotechnology Value Fund II, L.P., a Delaware limited
partnership, BVF Partners L.P., a Delaware limited partnership, and BVF Inc.,
a Delaware corporation, hereby agree and acknowledge that the information
required by this Schedule 13G, to which this Agreement is attached as an
exhibit, is filed on behalf of each of them. The undersigned further agree
that any amendments or supplements thereto shall also be filed on behalf of
each of them.
Dated: January 7, 2000
BIOTECHNOLOGY VALUE FUND, L.P.
By: BVF Partners L.P., its general partner
By: BVF Inc., its general partner
By: /s/ Mark N. Lampert
--------------------------
Mark N. Lampert
President
BIOTECHNOLOGY VALUE FUND II, L.P.
By: BVF Partners L.P., its general partner
By: BVF Inc., its general partner
By: /s/ Mark N. Lampert
--------------------------
Mark N. Lampert
President
BVF PARTNERS L.P.
By: BVF Inc., its general partner
By: /s/ Mark N. Lampert
--------------------------
Mark N. Lampert
President
BVF INC.
By: /s/ Mark N. Lampert
--------------------------
Mark N. Lampert
President
