IGENE BIOTECHNOLOGY INC
DEF 14A, 2000-05-11
AGRICULTURAL CHEMICALS
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                          SCHEDULE 14A
                         (Rule 14a-101)
             INFORMATION REQUIRED IN PROXY STATEMENT
                    SCHEDULE 14A INFORMATION
   Proxy Statement Pursuant to Section 14(a) of the Securities
            Exchange Act of 1934 (Amendment No        )
                                              --------

Filed by the Registrant    X
Filed by a Party other than the Registrant

Check the appropriate box:

     Preliminary Proxy Statement          Confidential, For Use
                                          Of the Commission Only
                                          (as permitted by Rule
                                          14a-6(e)(2))
 X   Definitive Proxy Statement
     Definitive Additional Materials
     Soliciting Material Under Rule 14a-12

                     Igene Biotechnology, Inc.
        ------------------------------------------------
        (Name of Registrant as Specified in Its Charter)

                               N/A
           ------------------------------------------
           (Name of Person(s) Filing Proxy Statement,
                  if Other Than the Registrant)

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     6(i)(1) and 0-11.

(1)  Title of each class of securities to which transaction
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computed pursuant to Exchange Act Rule 0-11 (set forth the amount
on which the filing fee is calculated and state how it was
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Exchange Act Rule 0-11(a)(2) and identify the filing for which
the offsetting fee was paid previously.  Identify the previous
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(1)  Amount previously paid:

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<PAGE>

                    IGENE BIOTECHNOLOGY, INC.
                      9110 Red Branch Road
                    Columbia, Maryland 21045

                         PROXY STATEMENT

Notice of Annual Meeting of Stockholders to be held June 6, 2000

       NOTICE  IS  HEREBY  GIVEN  that  the  Annual  Meeting   of
Stockholders of IGENE Biotechnology, Inc. (the "Company") will be
held  at  the offices of Kimelman & Baird, LLC, 100 Park  Avenue,
21st floor, New York, New York 10017 at 10:00 a.m. local time  on
June 6, 2000 for the following purposes:

     1.   To elect seven (7) Directors.
     2.   To  approve  the appointment of Berenson &  Company  as
          independent auditors of the Company for the fiscal year
          ending December 31, 2000.
     3.   To  transact  such  other business as may properly come
          before the meeting, or any adjournment thereof.

     Stockholders of record at the close of business  on  May  1,
2000,  shall  be  entitled to notice of,  and  to  vote  at,  the
meeting.

                         By order of the Board of Directors


                         /s/Stephen F. Hiu
                         ----------------------------------------
                         Stephen F. Hiu
                         President and Treasurer



Dated:    Columbia, Maryland
          May 3, 2000

IMPORTANT:   PLEASE  FILL IN, DATE, SIGN AND  MAIL  PROMPTLY  THE
ENCLOSED  PROXY IN THE POSTAGE-PAID ENVELOPE PROVIDED  TO  ASSURE
THAT YOUR SHARES ARE REPRESENTED AT THE MEETING.

The  date of this Proxy Statement is May 3, 2000, the approximate
date  on which this Proxy Statement and form of Proxy were  first
sent or given to stockholders.

<PAGE>

     The  accompanying  Proxy  is  solicited  by  the  Board   of
Directors  of  IGENE Biotechnology, Inc., a Maryland  Corporation
(the  "Company"), for use at the Annual Meeting  of  Stockholders
(the  "Meeting")  to be held on June 6, 2000, or any  adjournment
thereof, at which stockholders of record at the close of business
on  May  1, 2000 (the "Record Date") shall be entitled  to  vote.
The cost of solicitation of proxies will be borne by the Company.
The  Company  may  use  the services of its Directors,  officers,
employees  and  others  to  solicit  proxies,  personally  or  by
telephone.   Arrangements may also be made with brokerage  houses
and  other custodians, nominees, fiduciaries and stockholders  of
record  to forward solicitation material to the beneficial owners
of  stock  held  of  record  by such persons.   The  Company  may
reimburse  such solicitors for reasonable out-of-pocket  expenses
incurred by them in soliciting, but no compensation will be  paid
for their services.

      Each  proxy executed and returned by a stockholder  may  be
revoked  at  any time before it is voted by timely submission  of
written  notice of revocation or by submission of a duly executed
proxy  bearing  a  later date (in either  case  directed  to  the
Secretary of the Company) or, if a stockholder is present at  the
Meeting, he or she may elect to revoke his proxy and vote his  or
her shares personally.

     There is being mailed herewith to each stockholder of record
the  Company's Annual Report on Form 10-KSB for the  fiscal  year
ended December 31, 1999 and a Quarterly Report on Form 10-QSB for
the three months ended March 31, 2000.

      On  the  Record Date, the Company had 52,208,880 shares  of
Common Stock outstanding and entitled to vote with respect to all
matters  to be acted upon at the Meeting.  Each holder of  Common
Stock  is  entitled to one vote for each share of stock  held  by
such holder.

     On the Record Date, the Company also had 26,467 shares of 8%
Cumulative   Preferred  Stock  ("Series   A   Preferred   Stock")
outstanding and entitled to vote with respect to all  matters  to
be  acted upon at the Meeting.  Each holder of Series A Preferred
Stock  is entitled to two votes for each share of Preferred Stock
held  by  such  holder.  Holders of record of outstanding  Common
Stock  and  Series  A Preferred Stock will be  entitled  to  vote
together as a single class at the Meeting.

<PAGE>

      Pursuant  to the terms of the Company's Series A  Preferred
Stock,  as a consequence of the non-payment of dividends on  such
Stock  for  more than the past four consecutive dividend  payment
dates, the holders of Series A Preferred Stock, if they so elect,
may  vote as a separate class with respect to the election of two
additional directors, in accordance with the procedures set forth
in  the  Charter and by-laws of the Company. To date, the holders
of  the  Series A Preferred Stock have not exercised such  right.
In  the  event  they  exercise their right, the  Board  would  be
expanded to nine directors.

      The presence of holders representing a majority of all  the
votes entitled to be cast at the meeting will constitute a quorum
at  the  meeting.  In accordance with Maryland law,  abstentions,
but not broker non-votes, are counted for purposes of determining
the  presence  or  absence of a quorum  for  the  transaction  of
business.   Each item on the agenda must receive the  affirmative
vote  of  a majority of the voting power voted at the meeting  in
order  to pass.  Abstentions and broker non-votes are not counted
in  determining the votes cast with respect to any of the matters
submitted to a vote of stockholders.

Appraisal Rights

       Under   Maryland  law,  a  stockholder  of  a  corporation
participating in certain major corporate transactions may,  under
varying  circumstances, be entitled to appraisal rights  pursuant
to  which such stockholder may receive cash in the amount of  the
fair  market  value  of  his  or  her  shares  in  lieu  of   the
consideration  he  or  she  would  otherwise  receive    in   the
transaction.

An  objecting  stockholder has the right to  demand  and  receive
payment  of  the  fair  value of their  stock  from  a  successor
corporation  if the corporation merges with another  corporation.
Fair  value  of the stock will be determined as of the  close  of
business  on  the  day the stockholders voted on the  transaction
objected to.  A stockholder may not demand the fair value of  his
stock  and is bound by the terms of the transaction if the  stock
is listed on a national securities exchange or is designated as a
national  market  system  secruity on an  inter-dealer  quotation

<PAGE>

system by the National Association of Securities Dealers, Inc. on
the record date for determining stockholders entitled to vote  on
the  transaction objected to.  An objecting stockholder must file
a  written  objection  with  the corporation  at  or  before  the
stockholders'   meeting  at  which  the   transaction   will   be
considered.  Additionally, the objecting stockholder may not vote
in  favor of the transaction, and within 20 days after the  State
Department  of Assessments and Taxation accepts the  articles  of
merger,  must make a written demand on the successor for  payment
for  his stock, stating the number and class of shares for  which
he demands payment.  If the objecting stockholder does not comply
with  this section, he will be bound by the terms of the  merger.
Within  50  days  after the State Department of  Assessments  and
Taxation  accepts  the  articles for  record,  the  successor  or
objecting  stockholder  may petition a court  of  equity  for  an
appraisal to determine the fair value of the stock.  Finally,  if
the court finds that the objecting stockholder is entitled to  an
appraisal  of his stock, it shall appoint three (3) disinterested
appraisers to determine the fair value of the stock on terms  and
conditions  the  court  considers proper.   Within  60  days,  or
however long the court allows, the appraisers shall determine the
fair  value  of the stock as of the appropriate date and  file  a
report  with their conclusions.  Within 15 days after the  report
is  filed, any party may object to it and request a hearing.   If
the  appraiser's  report  is  confirmed  or  modified  by  order,
judgment  shall be entered against the successor and in favor  of
each  objecting  stockholder party to  the  proceeding.   If  the
appraisers' report is rejected, the court may determine the  fair
value  of  the  stock and enter judgment for the stockholder,  or
remit  the proceedings to the same or other appraisers  on  terms
and conditions it considers proper.

Financial Information

      Financial  information for the Company for the fiscal  year
ended  December  31,  1999 is included in  the  Company's  Annual
Report  on  Form 10-KSB, a copy of which accompanies  this  proxy
Statement.

       It  is  expected  that  the  following  business  will  be
considered at the meeting and action taken thereon:

<PAGE>

1.   ELECTION OF DIRECTORS

     Pursuant  to  the  By-Laws of the  Company,  the  number  of
Directors  of the Company has been set at seven members.   It  is
proposed to elect seven Directors at this Meeting to hold  office
for a one-year term until the 2001 Annual Meeting of Stockholders
and  until their successors are duly elected and qualify.  It  is
intended  that the accompanying form of Proxy will be  voted  for
the  nominees  set  forth  below, each of  whom  is  presently  a
Director  of  the Company.  If some unexpected occurrence  should
make  necessary,  in  the  Board  of  Directors'  judgment,   the
substitution  of  some other person or persons  for  any  of  the
nominees,  shares  will be voted for such other  persons  as  the
Board  of  Directors may select.  The Board of Directors  is  not
aware that any nominee may be unable or unwilling to serve  as  a
Director.   The  following table sets forth  certain  information
with respect to the nominees.

<TABLE>
<CAPTION>
                      NOMINEES FOR ELECTION

Name                     Age  Position with IGENE
- -------------------      ---  -----------------------------------
<S>                      <C>  <C>
Michael G. Kimelman      61   Chairman of the Board of Directors
Thomas L. Kempner        72   Vice Chairman of the Board of
                              Directors
Stephen F. Hiu           43   Director, President,
                              Treasurer, and Director
                              of Research and Development
Patrick F. Monahan       49   Director, Secretary, and
                              Director of Manufacturing
Joseph C. Abeles         85   Director
John A. Cenerazzo        76   Director
Sidney R. Knafel         69   Director

</TABLE>

MICHAEL  G.  KIMELMAN was elected a Director of  the  Company  in
February  1991  and Chairman of the Board of Directors  in  March
1991.   He is the Managing Partner of Kimelman & Baird, LLC.   He
is  a  founder of Blue Chip Farms, a standard bred horse-breeding
farm, and has been an officer of the same since its inception  in
1968.   Mr. Kimelman is currently a Director of the Harness Horse
Breeders  of  New  York State and serves  on  the  Board  of  the
Hambletonian Society.

<PAGE>

THOMAS L. KEMPNER is Vice Chairman of the Board of Directors  and
has been a Director of the Company since its inception in October
1981.  He is and has been Chairman and Chief Executive Officer of
Loeb Partners Corporation, investment bankers, New York, and  its
predecessors since February 1978.  He is currently a Director  of
Alcide  Corporation, CCC Information Services Group,  Inc.,  Fuel
Cell Energy, Inc., Intermagnetics General Corp., and Roper Starch
Worldwide, Inc.  He is a Director Emeritus of Northwest Airlines,
Inc.

STEPHEN  F.  HIU was appointed President and Treasurer  in  March
1991,  and  elected  a  Director in August  1990.   He  has  been
Director  of  Research and Development since  January  1989  and,
prior  thereto, was Senior Scientist since he joined the  Company
in  December 1985.  He was a post-doctoral Research Associate  at
the   Virginia   Polytechnic  Institute  and  State   University,
Blacksburg, Virginia, from January 1984 until December 1985.  Dr.
Hiu  holds  a  Ph.D.  degree in microbiology  from  Oregon  State
University  and  a  B.S. degree in biological sciences  from  the
University of California, Irvine.

PATRICK  F.  MONAHAN was appointed Director of Manufacturing  and
elected  a Director of the Company in April 1991 and was  elected
as  Secretary  in September 1998.  He has managed  the  Company's
fermentation  pilot  plant  since  1982,  and  its  manufacturing
operation since its inception in 1998. Prior thereto,  he  was  a
technical  specialist in the fermentation  pilot  plant  of  W.R.
Grace  and  Co. from 1975 to 1982.  He received an  Associate  in
Arts  degree  in biology from Allegheny Community College  and  a
B.S.  degree in biology with a minor in Chemistry from  Frostburg
State College, Frostburg, Maryland.

JOSEPH  C. ABELES, private investor, was elected Director of  the
Company  on February 28, 1991.  Mr. Abeles serves as Director  of
Intermagnetics  General Corporation, Bluegreen  Corporation,  and
Ultralife Batteries, Inc.

JOHN A. CENERAZZO was Chairman of the Board from November 1989 to
April  1991.   He served as President of the Company from  August
1988  through  September  1989 and  has  been  a  Director  since
September  1987.   He  also serves as a  Director  of  U.S.  Axle
Corporation  and Chairman and Director of Technicon  Enterprises,
Inc.

<PAGE>

SIDNEY R. KNAFEL, a Director of the Company since 1982, has  been
Managing  Partner of SRK Management Company, a private investment
concern,   New   York,   since   1981,   Chairman   of    Insight
Communications,  Inc. since 1985, and of BioReliance  Corporation
since  1982.  Mr. Knafel is also currently a Director of Cellular
Communications   International,  Inc.,   CoreComm   Incorporated,
General  American Investors Company, Inc.,  and NTL Incorporated.
Committees of the Board of Directors

      The  Company  has two standing committees of the  Board  of
Directors.  Set forth below is a description of the functions  of
those  committees and the members of the Board of  Directors  who
serve on such committees.

Audit Committee

       The   responsibilities  of  the  Audit  Committee  include
recommending to the Board of Directors the independent  certified
public  accountants to conduct the annual audit of the books  and
accounts  of  the Company, reviewing the proposed  scope  of  the
audit  and  approving  the audit fees  to  be  paid.   The  Audit
Committee  also  reviews, with the independent  certified  public
accountants  and with the Company's management, the adequacy  and
effectiveness of the internal auditing, accounting and  financial
controls  of  the Company.  There were no meetings of  the  Audit
Committee in 1999.  The functions of the Committee were performed
by the Board during 1999.

Compensation Committee

      The  Compensation Committee approves the  salaries  of  all
officers  and  certain other employees of the Company.   It  also
supervises  the  administration of all benefit  plans  and  other
matters  affecting  executive compensation,  subject  to  further
approval  of  the  Board  of  Directors.   The  members  of   the
Compensation Committee during 1999 were Messrs. Thomas L. Kempner
and Sidney R. Knafel.  There were no meetings of the Compensation
Committee in 1999.

<PAGE>

Board Compensation

      During 1999, Directors were not compensated for their Board
or  Committee activities.  The Board of Directors held 4 meetings
in  1999.  Each Director of the Company attended in excess of 75%
of  the  total  number  of  meetings of the  Board  of  Directors
including  committee meetings for which each respective  director
was a member.

Executive Compensation

      During  the  last  completed  fiscal  years,  no  executive
officer's  annual cash compensation exceeded $100,000.  Following
the  resignation  of the Company's former CEO, during  1998,  the
functions of chief executive officer have been performed  by  the
Company's  Board  of Directors (Messrs. Abeles,  Cenerazzo,  Hiu,
Kempner,  Kimelman, Knafel, and Monahan) acting as a group.   The
Directors  were  not  compensated for their  Board  or  Committee
Activities.

     Other than the 1986 and 1997 employee stock option plans and
the  Simple Retirement Plan described below, the Company  has  no
profit sharing or incentive compensation plans.


Simple Retirement Plan
- ----------------------

     Effective  February  1, 1997 the Company  adopted  a  Simple
Retirement Plan under Internal Revenue Code Section 408(p).   The
plan  is  a  defined contribution plan, which covers all  of  the
Company's  employees who receive at least $5,000 of  compensation
for  the  preceding  year.   The plan permits  elective  employee
contributions.   The Company makes a nonelective contribution  of
2%  of each eligible employee's compensation for each year.   The
Company's  contributions to the plan for 1999 were $6,569,  which
is expensed in the 1999 statement of operations.

Stock Option Plan
- -----------------

    The  1997  Stock Option Plan (the "Plan"), which was approved
by  the stockholders on November 17, 1997, and which succeeds the
1986  Stock Option Plan, provides for the issuance of options  to
acquire up to 20,000,000 shares of Common Stock of the Company.

    The  Plan  is  administered by a committee of  the  Board  of
Directors.

<PAGE>

    The  purpose of the Plan is to advance the interests  of  the
Company  by encouraging and enabling the acquisition of a  larger
personal  proprietary interest in the Company by  directors,  key
employees,  consultants  and  independent  contractors  who   are
employed  by,  or  perform  services for,  the  Company  and  its
subsidiaries  and  upon  whose judgment  and  keen  interest  the
Company  is largely dependent for the successful conduct  of  its
operations.  It is also expected that the opportunity to  acquire
such  a  proprietary  interest will enable the  Company  and  its
subsidiaries to attract and retain desirable personnel, directors
and other service providers.

    Options  are exercisable at such rates and times  as  may  be
fixed by the committee.  Options become exercisable in full  upon
(i)  the holder's retirement on or after his 65th birthday,  (ii)
the  disability  or death of the holder, (iii) or  under  special
circumstances as determined by the Committee.  Options  generally
terminate  on  the  tenth  business day  following  cessation  of
service  as  an  employee,  director, consultant  or  independent
contractor.

    Options  may  be exercised by payment in full of  the  option
price in cash or check, or by delivery of previously-owned shares
of  common stock having a total fair market value on the date  of
exercise  equal to the option price, or by such other methods  as
permitted by the Committee.

    The  Plan  contains anti-dilution provisions in the event  of
certain corporate transactions.

    The  Board  of  Directors may at any time withdraw  from,  or
amend   the   Plan  and  any  options  not  heretofore   granted.
Stockholder  approval is required to (i) increase the  number  of
shares  issuable  under  the plan, (ii) increase  the  number  of
options  which  may be granted to any individual during  a  year,
(iii)  or  change  the class of persons to whom  options  may  be
granted.   No  options  shall be granted  under  the  Plan  after
September 19, 2007.

    Options  to  acquire 12,748,250 shares of common  stock  have
been  granted  under  the 1986 and 1997 Stock  Option  Plans  and
11,248,250 options are outstanding under the Plans as of  May  1,
2000.

<PAGE>

Security Ownership of Certain Beneficial Owners and Management

      The  following table sets forth information as  of  May  1,
2000,  with  respect to beneficial ownership  of  shares  of  the
Company's  outstanding Common Stock by (i) each person  known  to
the  Company  to own more than five percent of its Common  Stock,
(ii)  each  Director,  and  (iii)  all  Directors  and  executive
officers as a group.

<TABLE>
<CAPTION>
                                     Number of
Name and Address                     Shares            Percent*
- -----------------------------        -------------     ----------

Directors and Officers:
- ----------------------
<S>                                  <C>               <C>
Joseph C. Abeles                      15,012,789(1)      23.06%
     c/o Abel Associates
     220 E. 42nd Street
     New York, NY 10017

John A. Cenerazzo                      1,912,456(2)       3.55%
     Stokesay Castle Lane
     Reading, PA 19606

Stephen F. Hiu                         5,020,300(3)       8.78%
     c/o IGENE Biotechnology, Inc.
     9110 Red Branch Road
     Columbia, MD 21045

Thomas L. Kempner                     66,532,836(4)      63.25%
     c/o Loeb Partners Corporation
     61 Broadway
     New York, NY 10006

Michael G. Kimelman                    9,821,950(5)      16.16%
     c/o Kimelman & Baird, LLC
     100 Park Avenue
     New York, NY 10017

Sidney R. Knafel                      63,659,933(6)      62.00%
     c/o SRK Management
     126 East 56th Street
     New York, NY 10022

Patrick F. Monahan                     3,064,200(7)       5.55%
     c/o IGENE Biotechnology, Inc.
     9110 Red Branch Road
     Columbia, MD 21045

<PAGE>

                                     Number of
Name and Address                     Shares            Percent*
- -----------------------------        -------------     ----------

Directors and Officers (continued):
- ----------------------------------

All Directors and Officers           165,024,464(8)      88.39%
     As a Group (7 persons)

Others:

Thomas R. Grossman                     3,192,150(9)       5.95%

Fraydun Manocherian                    6,734,725(10)     11.92%


- ------------------------

</TABLE>

*    Under  the  rules of the Securities and Exchange Commission,
     the  calculation of the percent assumes for each person that
     only  such  person's warrants, options or convertible  notes
     are   exercised  or  converted  and  that  no  other  person
     exercises  or  converts  outstanding  warrants,  options  or
     convertible notes.  Accordingly, these percentages  are  not
     on a fully-diluted basis.

(1)  Includes  2,109,404  shares,  2,250  shares  issuable   upon
     conversion  of  1,125 shares of Series  A  Preferred  Stock,
     $311,663  in  long-term  notes  convertible  into  3,782,083
     shares,  and  warrants  to purchase 9,093,427  shares.  Also
     includes  4,140  shares held by his wife and  12,500  shares
     issuable  upon  conversion  of  6,250  shares  of  Series  A
     Preferred Stock held by his wife.

(2)  Includes  283,458  shares, warrants  to  purchase  1,103,513
     shares,   32,750   shares  subject  to   options   currently
     exercisable and $40,622 in long-term notes convertible  into
     492,321 shares.  Also includes 414 shares held by his wife.

(3)  Includes  65,300  shares  held by Dr.  Hiu,   and  4,955,000
     shares subject to options currently exercisable.

(4)  Includes  386,972  shares and warrants to  purchase  536,917
     shares  held  by Mr. Kempner; 5,666,916 shares, $140,873  in
     long-term  notes  convertible  into  1,616,065  shares   and
     warrants to purchase 21,628,007 shares held by a trust under
     which  Mr.  Kempner  is  one of two trustees  and  the  sole
     beneficiary;  1,482,987 shares, $79,200 in  long-term  notes
     convertible  into 1,147,670 shares and warrants to  purchase
     4,622,848 shares held by a trust under which Mr. Kempner  is
     one  of  two  trustees and a one-third beneficiary;  182,526
     shares  and warrants to purchase 98,565 shares held  by  Mr.

<PAGE>

     Kempner's wife; 203,880 shares  and  warrants  to   purchase
     110,095 shares held by trusts under which Mr. Kempner is one
     of  two  trustees  and his brothers are  beneficiaries;  and
     5,626,918  shares,  $140,872 in long-term notes  convertible
     into  1,616,065  shares and warrants to purchase  21,606,405
     shares held by a trust under which Mr. Kempner is one of two
     trustees and one of his brothers is the beneficiary.

(5)  Includes   251,104   shares,  1,500,000  options   currently
     exercisable,  warrants  to  purchase  5,325,672  shares  and
     $63,070  in long-term notes convertible into 804,568  shares
     held  by  Mr.  Kimelman. Also includes  831,600  shares  and
     warrants  to  purchase 750,890 shares  held  by  Kimelman  &
     Baird,  LLC,  in which Mr. Kimelman has a 50% interest,  and
     181,656  shares  held by M. Kimelman &  Co.,  in  which  Mr.
     Kimelman  has  a  60% interest.  Also includes  warrants  to
     purchase  176,460  shares  held by his wife,  in  which  Mr.
     Kimelman disclaims any beneficial interest.

(6)  Includes  13,190,551 shares, warrants to purchase 46,753,677
     shares,  and  $306,200 in long-term notes  convertible  into
     3,715,706 shares owned or beneficially owned by Mr. Knafel.

(7)  Includes  64,200 shares held by Mr. Monahan,  and  3,000,000
     shares  subject to options currently exercisable.

(8)  Includes  30,532,026  shares,  9,487,750  shares  which  are
     subject  to  options  currently exercisable  or  exercisable
     within  60  days, unexpired warrants to purchase 111,815,462
     shares,  14,750  shares subject to the conversion  of  7,375
     shares of redeemable preferred stock, and $1,082,500 in long-
     term notes convertible into 13,174,478 shares.

(9)  Includes 1,753,400 shares and warrants to purchase 1,438,750
     shares.

(10) Includes    2,455,525  shares  and  warrants   to   purchase
     4,279,200 shares.


Compensation Committee Interlocks and Insider Participation

      Thomas L. Kempner and Sidney R. Knafel are members  of  the
Compensation  Committee. None of the executive  officers  of  the
Company  has  served  on the Board of Directors  or  compensation
committee of any other entity whose officers serve either on  the
Company's Board of Directors or Compensation Committee.

<PAGE>

Certain Relationships and Transactions

    The Company distributed, to holders of record on February 13,
1998, transferable rights to subscribe for and purchase 0.54 of a
Unit  for each share of common share or equivalent owned by  such
holder.  Each Unit entitled the holder to receive $0.10 principal
amount  of  8% Notes due March 31, 2003 and warrants to  purchase
one  share  of  common stock at an exercise price  of  $0.10  per
share.   Common  shares  or equivalents included:  Common  Stock,
Preferred    Stock,   unexpired   warrants,   options   currently
exercisable,  and  convertible notes  outstanding.   The  Company
raised  $5,000,000 through this Rights Offering, which was  fully
subscribed, and issued $5,000,000 in 8% Notes due March 31,  2003
and  50,000,000  warrants to subscribers. Certain  directors  and
investors  agreed  to  purchase Units  equal  to  the  difference
between  $2,000,000  and the proceeds from the  Rights  Offering;
however, concurrently therewith the Company was required to repay
$1,875,000  in  promissory notes.  The  Rights  Offering  expired
March  31,  1998.   In  consideration of  certain  directors  and
investors  agreeing to subscribe to Units such that  the  Company
receives  at  least  $2,000,000, the  Company  issued  additional
warrants  to these directors and investors to purchase 20,000,000
shares  of  common  stock, exercisable at  $0.10  per  share  and
expiring ten years after issue.

     During  1998, the Company also issued 4,000,000 warrants  to
purchase common shares, at $.10 per share, to its Chairman of the
Board; and 9,500,000 warrants to purchase common shares, at  $.10
per  share, to certain directors who were the holders of $950,000
in demand notes issued during 1998.

     During  1999, the Company also issued 1,500,000  options  to
purchase  common shares, at $.05 per share (which was the  market
value of the stock as of the date issued), to its Chairman of the
Board under its 1997 Stock Option Plan.

     During  1999,  the Company issued to certain  directors  and
other  accredited investors 24,791,668 new shares of common stock
at  prices ranging from $.05 to $.08, based on the current market
price  of  the Company's stock at the time of issue.   The  total
proceeds received in these issues was $1,500,000.  In return  for
committing  to  these investments, these investors also  received
24,791,668  warrants  to  purchase  shares  of  common  stock  at
equivalent prices (ranging from $.05 to $.08 per share, based  on
the  current market price of the Company's stock at the  time  of
issue),  expiring  10 years from the dates of issue.   The  funds
received  in  these  transactions  have  been  used  to  continue
operations  of the Company and to fund legal expenses  associated
with on going litigation (See item 3. Legal Proceedings).

<PAGE>

Section 16(a) Beneficial ownership Reporting Compliance

     The  Company believes that during 1999, all of its officers,
directors  and  holders  of more than  5%  of  its  Common  Stock
complied with all filing requirements under Section 16(a) of  the
Securities  Exchange  Act of 1934, except  as  follows:  In  1997
certain  directors  of  the Company made  various  loans  to  the
Company.   The  loans  are evidenced by demand  promissory  notes
convertible  into  Common  Stock. These directors  also  received
warrants to purchase shares of Common Stock in 1997 and  1998  in
conjunction  with  the  1997 notes and a  1998  rights  offering.
During  1999,  certain  directors and other accredited  investors
also  purchased stock through direct purchases of new  stock  and
received  warrants  in  conjunction  with  these  purchases.  The
Company   believes   that  none  of  the   foregoing   securities
transactions were reported on Forms 4 or Forms 5 filed  with  the
Securities  and Exchange Commission.  In making this  disclosure,
the   Company  has  relied  solely  on  representations  of   its
directors,  officers and more than 5% holders and  on  copies  of
reports  that  have been filed with the Securities  and  Exchange
Commission.

2.   APPOINTMENT OF INDEPENDENT AUDITORS

     The  Board of Directors of the Company has selected Berenson
&  Company as independent auditors of the Company for the  fiscal
year  ending December 31, 2000.  A representative of  Berenson  &
Company is not expected to be present at the meeting.

      The Board of Directors of the Company recommends a vote FOR
approval  of  the  appointment  of  Berenson  &  Company  as  the
Company's auditors.

3.   OTHER MATTERS

Stockholder Proposals

      Proposals of stockholders intended to be presented  at  the
Company's 2001 Annual Meeting of Stockholders must be received by
the  Company  on or prior to April 30, 2001, to be  eligible  for
inclusion in the Company's Proxy Statement and form of  Proxy  to
be used in connection with such meeting.

Other Business

     At the date of this Proxy Statement, the only business which
the  Board  of Directors intends to present or knows that  others
will  present at the Meeting is that hereinabove set  forth.   If
any  other  matter  or matters are properly  brought  before  the
meeting, or any adjournment thereof, it is the intention  of  the
persons named in the accompanying form of Proxy to vote the Proxy
on such matters in accordance with their judgment.

<PAGE>

Incorporation of Certain Documents by Reference

      The  Company's Annual Report on Form 10-KSB for the  fiscal
year ended December 31, 1999, and Quarterly Report on Form 10-QSB
for  the  three  months  ended March 31, 2000,  copies  of  which
accompany  this  Proxy  Statement,  are  incorporated  herein  by
reference.

      All  documents  filed by the Company pursuant  to  Sections
13(a), 13(c), 14 or 15(d) of the securities Exchange Act of  1934
(the  "Exchange  Act")  subsequent to  the  date  of  this  Proxy
Statement  and  prior  to  the meeting  shall  be  deemed  to  be
incorporated by reference herein and to be a part hereof from the
date  of the filing of such reports and documents.  Any statement
contained in a document incorporated or deemed to be incorporated
by  reference herein shall be deemed to be modified or superseded
for  the  purposes of this proxy Statement to the extent  that  a
statement  contained  herein or in any other  subsequently  filed
document  which also is incorporated or deemed to be incorporated
by  reference  herein modifies or supersedes such statement.  Any
statement  so modified or superseded shall not be deemed,  except
as  so modified or superseded, to constitute a part of this Proxy
Statement.

      The Company will provide, without charge, to each person to
whom  a  copy  of  this  Proxy Statement is delivered,  upon  the
written or oral request of such person and by first class mail or
other equally prompt means within one business day of receipt  of
such  request, a copy of any or all of the documents incorporated
herein  by  reference (other than exhibits, unless such  exhibits
are  specifically  incorporated herein by  reference).   Requests
should  be  directed to: Investor Relations, IGENE Biotechnology,
Inc., 9110 Red Branch Road, Columbia, Maryland 21045.

      The Company is subject to the informational requirements of
the  Exchange  Act and, in accordance therewith,  files  reports,
proxy  or  information statements and other information with  the
commission.   Such  reports,  proxy  or  information  statements,
exhibits  and  other information filed by the  Company  with  the
Commission  can  be inspected and copies at the  pubic  reference
facilities  maintained by the Commission at Room 1024,  Judiciary
Plaza, 450 Fifth Street, N.W., Washington, D.C. 20549, and at the
Regional Offices of the Commission at 7 World Trade Center  (13th
Floor),  New York, New York 10048 and Northwestern Atrium Center,
500  Madison  Street,  Suit 1400, Chicago,  Illinois  60661-2511.

<PAGE>

Copies  of such materials can be obtained by mail from the Public
Reference  Section  of  the Commission at  Room  1024,  Judiciary
Plaza,  450 Fifth Street, N.W., Washington, D.C. 20549,  and  its
public  reference facilities in New York, New York  and  Chicago,
Illinois,  at prescribed rates. The Commission also maintains  an
Internet  web  site, whose address is www.sec.gov  that  contains
reports,  proxy and information statements and other  information
regarding issuers who file electronically with the commission.





                                   /s/Stephen F. Hiu
                                   ------------------------------
                                   Stephen F. Hiu
                                   President and Treasurer


Dated: May 3, 2000

<PAGE>


APPENDIX 1   FORM OF PROXY





                    IGENE BIOTECHNOLOGY, INC.


       2000 Annual Meeting of Shareholders - June 6, 2000
   This Proxy is Solicited on Behalf of the Board of Directors


The  undersigned  hereby  appoints Stephen  F.  Hiu,  Michael  G.
Kimelman  and Thomas L. Kempner, and each of them the proxies  of
the  undersigned with full power of substitution to vote  at  the
Annual Meeting of Stockholders of the Company to be held at 10:00
a.m.  on  Tuesday,  June  6,  2000, and  at  any  adjournment  or
adjournments  thereof (the "Meeting"), with all power  which  the
undersigned would have if personally present, hereby revoking any
proxy  heretofore  given.   The undersigned  hereby  acknowledges
receipt  of the proxy statement at the Meeting and instructs  the
proxies to vote as directed on the reverse side.

The Board of Directors recommends a vote "FOR" all proposals.

                 (To Be Signed on Reverse Side)

<PAGE>

 X   Please mark your
     votes as in this
     example.

                  FOR    WITHHOLD

1.   Election     ____     ____   Nominees: Joseph C. Abeles
     of                                     John A. Cenerazzo
     Directors                              Stephen F. Hiu
     (Instruction: To withhold              Thomas L.Kempner
      authority to vote for any             Michael G. Kimelman
      individual nominee, write             Sidney R. Knafel
      that nominee's name below)            Patrick F. Monahan

     ---------------------------


2.   To  ratify the appointment Berenson & Company as independent
     auditors for the fiscal year ending December 31, 2000.

                    FOR    AGAINST ABSTAIN

                    ____     ____     ____


3.   With discretionary authority upon such other matters as  may
     properly come before the Meeting.


PLEASE   RETURN  THE  PROXY  CARD  PROMPTLY  USING  THE  ENCLOSED
ENVELOPE.




Signature                                 Date
          ------------------------------       ------------------
Signature                                 Date
          ------------------------------       ------------------
          (SIGNATURE IF HELD JOINTLY)


Note:       Please  sign  exactly  as  name  appears   on   stock
certificate.  When shares are held by joint tenants  both  should
sign.  When signing as attorney, executor, administrator, trustee
or  guardian, please give full title as  such.  If a corporation,
please  sign  in  full  corporate  name  by  President  or  other
authorized  officer.  If a  partner,  please  sign in partnership
name by authorized person.

<PAGE>

APPENDIX 2   LETTER TO STOCKHOLDERS



9110 Red Branch Road
Columbia, Maryland 21045-2024
(410) 997-2599


April 17, 2000


Dear Shareholder:

We  are pleased to report to you that in the last year, Igene has
truly  begun the transition from being a Research and Development
company to a commercial enterprise with real products. Due to the
persistence of the entire Igene team, our Company has made  great
progress in every aspect of its business: research, manufacturing
and sales.

In 1999, Igene began probably the largest commercial fish feeding
study  in  the  world  using  its  natural  astaxanthin  product,
AstaXin(R).  This  study, which made use  of  a  newly  developed
proprietary  strain  of yeast developed by  Igene  in  1998,  was
conducted with more than a half million salmon and trout and  was
performed  in  cooperation with a dozen Chilean  fish  producers.
Those  testing the product believe the results obtained thus  far
confirm  that Igene's natural product for pigmentation  of  farm-
raised  salmon and trout  is comparable, if not superior, to  the
synthetic product that currently dominates that market.   Due  to
the  highly  positive documented results obtained, the  companies
which  have  completed their initial study have begun  to  expand
their usage of our product in their fish feed.  This resulted  in
revenue  during  the  fourth quarter  of  1999  of  approximately
$18,000,  which  continued  in  the  first  quarter  of  2000  at
approximately  $78,000.  It now appears that our  second  quarter
sales  will  be  at least double that of the first  quarter.   As
additional  companies  complete their trials  we  are  cautiously
optimistic that our sales will continue to grow.

To  support  the Company's growing business in Chile, Igene  will
complete  the  establishment of  Igene Chile,  Ltda.,  a  Chilean
subsidiary  based in Puerto Montt, Chile, in the 2nd  quarter  of
2000.  Since 1999, Igene has maintained a local office  in  Chile
and  has hired a full time technical representative, who together
with  Igene staff traveling from Columbia, Maryland have provided
technical  and  sales support to our customers  in  Chile.   This
technical support was instrumental in creating sales.   Once  the
customers were knowledgable about our product, they were  willing
to  try  it,  and once they saw the results they were willing  to
purchase  it.  Consequently, the Company intends to continue  and
expand   its   technical  service  and  has  recently   added   a
veterinarian  specializing in aquatic  health  to  its  technical
staff in Chile.

<PAGE>

To  complement the fish feeding studies in Chile, we also  report
the  preliminary  findings of an independent study  conducted  by
Akvaforsk  in Norway.  This highly regarded aquaculture  research
facility  has shown the efficiency of Igene's proprietary  enzyme
technology for making 98% of the natural astaxanthin contained in
the  yeast available for uptake by salmon and trout, while  other
competitors'  processes  are less than  half  as  effective.   In
addition,  the  stability of the product through  the  commercial
feed production process was confirmed.

These  successful results and the beginning of product  sales  in
Chile  have  prompted  Igene  and its  manufacturing  partner  to
negotiate   a   new   agreement  to  make  available   additional
manufacturing  capacity.   The Company  is  capable  of  tripling
capacity  within  three months, if necessary, and  to  nine  fold
within a year.

At  Igene's  Research and Development Center and pilot  plant  in
Maryland,   we continue to make significant improvements  in  the
strain  and  manufacturing  process.   These  improvements   have
resulted in reductions in our cost of manufacture and an  overall
increase in  product yields.  It is anticipated that by operating
at  maximum efficiency at our manufacturing plant in Mexico  City
and  by successfully implementing  improvements developed in  our
pilot  plant,  the  Company will be able  to  produce  a  natural
astaxanthin product which is significantly more efficient in  its
pigmenting ability and less expensive to manufacture.

With  the approval of the Canadian government this past year  for
the use of Igene's natural astaxanthin product in fish feeds, the
potential for additional market opportunities has increased.  The
Company  continues to actively pursue registration and  approvals
for its product in the European Union.

In  January  2000,  the Company hired a marketing  consultant  to
begin the development of a marketing plan for the production  and
sale   of   a  dietary  supplement  containing  Igene's   natural
astaxanthin  product. Published data has already  indicated  that
astaxanthin   is  several  hundred  times  more  potent   as   an
antioxidant  than  vitamin E.  By utilizing and adapting  Igene's
technology developed for its fish pigmentation product, Igene may
be able to expand into this new market with a natural astaxanthin
supplement.

All  of the above would not have been accomplished except for the
continuing   dedication  and  technical  expertise   of   Igene's
employees  both  in Maryland and in Chile, the  guidance  of  our
Board  of  Directors,  and the incredible  financial  loyalty  of
Thomas Kempner and Sidney Knafel of our Board.

Sincerely,

Michael G. Kimelman
Chairman


Stephen F. Hiu
President



<PAGE>

SAFE HARBOR.  Except for  statements  of  historical  fact,   the
statements  in  this  press  release are  forward-looking.   Such
statements  are  subject to a number of risks  and  uncertainties
that  could  cause actual results to differ materially  from  the
statements made.  These factors include, but are not limited  to,
general  economic  conditions, changes in  sales  levels  to  our
largest  customers, weather patterns, risks associated  with  the
acceptance  of new products, competition, and other factors  more
fully  detailed  in  the Company's recent  quarterly  10-QSB  and
annual   10-KSB   filings  with  the  Securities   and   Exchange
Commission.




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