IGENE BIOTECHNOLOGY INC
NTN 10K, 2000-03-17
AGRICULTURAL CHEMICALS
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           FORM 12B-25 NOTIFICATION OF LATE FILING
                          SEC FILE NUMBER
                          CUSIP NUMBER

                      UNITED STATES
               SECURITIES AND EXCHANGE COMMISSION
                Washington, D.C. 20549


(Check One): x Form 10-K   Form 20-F   Form 11-K   Form 10-Q   Form N-SAR

For Period Ended:   December 31, 1999

Transition Report on Form 10-K
Transition Report on Form 20-F
Transition Report on Form 11-K
Transition Report on Form 10-A
Transition Report on Form N-SAR

For the Transition
Period Ended:

Read Instruction (on back page) Before Preparing Form, Please Print or Type.
Nothing in this form shall be construed to imply that the Commissions have
verified any information contained herein.

If the notification relates to a portion of the filing checked above,
identify the item(s) to which the notification relates:

PART I - REGISTRATION INFORMATION (Official Text)

Full Name of Registrant:      IGENE Biotechnology, Inc.
Former Name if Applicable:
Address of Principal Executive
  Office (Street and Number): 9110 Red Branch Road
City, State and Zip Code:     Columbia, Maryland 21045-2024

PART II - RULES 1b-25(b) AND (c) (Official Text)

If the subject report could not be filed without unreasonable
effort or expense and the registrant seeks relief pursuant to
Rule 12b-25(b), the following should be completed. (Check box
if appropriate)     x

(a)  The reasons described in reasonable detail in Part III
     of this form could not be eliminated without unreasonable
     effort or expense;
(b)  The subject annual report, semi-annual report, transition
     report on Form 10-K, Form 20-F, 11-K, form N-SAR, or
     portion thereof, will be filed on or before the
     fifteenth calendar day following the prescribed due
     date; or the subject quarterly report of transition
     report on Form 10-Q, or portion thereof will be filed on
     or before the fifth calendar day following the
     prescribed due date; and
(c)  The accountant's statement or other exhibit required by
     Rule 12b-25(c) has been attached if applicable.

PART III - NARRATIVE (Official Text)

State below in reasonable detail the reasons why the Form 10-K,
11-K, 10-Q, N-SAR, or the transition report or portion
thereof, could not be filed within the prescribed time
period. (Attach Extra Sheets if Needed)

PART IV - OTHER INFORMATION (Official Text)

(1)  Name and telephone number of person to contact in
     regard to this notification
          Stephen F. Hiu
          410-997-2599
(2)  Have all other periodic reports required under Section
     13 or 15(d) of the Securities Exchange Act of 1934 of
     Section 30 of the Investment Company Act of 1940 during
     the preceding 12 months or for such shorter period that
     the registrant was required to file such report(s) been
     filed?  If answer is no, identify report(s). YES
(3)  Is  it anticipated that any significant change in
     results of operations from the corresponding period for
     the last fiscal year will be reflected by the earnings
     statement to be included in the subject report or
     portion thereof?
     NO

If so, attach an explanation of the anticipated change, both
narratively  and quantitatively, and, if appropriate,  state
the reasons why a reasonable estimate of the results cannot
be made.


Name of Registrant as Specified in Charter:  IGENE
Biotechnology, Inc.  has caused this notification to be signed
on its behalf by the undersigned hereunto duly authorized.

Date:     March 17, 2000
By:  /s/  Stephen F. Hiu, Ph.D., President

INSTRUCTIONS:

The  form may be signed by an executive officer of the
registrant or  by  any  other duly authorized
representative. The  name  and title  of  the person
signing the form shall be typed or  printed beneath  the
signature.  If the statement is signed on behalf  of the
registrant  by an authorized representative (other  than
an executive officer), evidence of the representative's
authority to sign on behalf of the registrant shall be
filed with the form.

                        ATTENTION

Intentional misstatements of omissions of fact
constitute Federal Criminal Violations (See 18 U.S.C.
1001).

          GENERAL INSTRUCTIONS (Official Text)

1.   This form is required by Rule 12b-25 (17 CFR 240.12b-25) of
     the General Rules and Regulations under the Securities
     Exchange Act of 1934.
2.   One signed original and four conformed copies of this form
     and amendments thereto must be completed and filed
     with the Securities and Exchange Commission,
     Washington, D.C. 20549, in accordance with Rule 0-3 of
     the General Rules and Regulations under the Act. The
     information contained in or filed with the form will
     be made a matter of public record in the Commission
     files.
3.   A manually signed copy of the form and amendments thereto
     shall be filed with each national securities exchange
     on which any class of securities of the registrant is
     registered.
4.   Amendment to the notification must also be filed on Form 12b-
     25 but need not restate information that has been
     correctly furnished. The form shall be clearly
     identified as an amendment notification.
5.   Electronic Filers.  This form shall not be used by
     electronic filers unable to timely file a report solely due to
     electronic difficulties. Filers unable to submit a
     report within the time period prescribed due to
     difficulties in electronic filing should comply with
     either Rule 201 or Rule 202 of Regulation S-T (232.201
     or 232.202 of this chapter) or apply for an adjustment
     in filing date pursuant to Rule 13(b) of Regulation S-T
     (232.13(b) of this chapter). (Amended by Sec Act Rel No.
     7122, Esch Act Rel No. 35113, eff 1/30/95).


INDEPENDENT AUDITORS REPORT


March 15, 2000


                                          Berenson & Company LLP
                       Certified Public Accounts and Consultants
                                            135 West 50th Street
                                              New York, NY 10020
                                                    212-977-6800
                               FAX: 212-245-3808 or 212-245-7098
                                         http://www.berenson.com
                                         email:[email protected]
                                       1912 Sunderland Place, NW
                                            Washington, DC 20036
                                                    202-331-1044
                                               FAX: 202-331-1085

United States Security and
  Exchange Commission
Washington, D.C. 20549

Re:  Igene Biotechnology, Inc.
     EIN:  52-1230461

To Whom It May Concern:

We are the independent auditors for Igene Biotechnology,
Inc.  We are unable at this point in time to express an
opinion on the Company's December 31, 1999 financial
statements or review the 10KSB as Igene is awaiting the
outcome of significant subsequent events which could
impact the financial statement disclosures.

Respectfully yours,

/s/ Berenson & Company LLP





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