VITRO DIAGNOSTICS INC
8-K, 2000-08-22
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT

     Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934.

        Date of Report (Date of Earliest Event Reported): August 7, 2000
                                                          --------------

                             VITRO DIAGNOSTICS, INC.
             ------------------------------------------------------
             (Exact name of registrant as specified in its charter)


    Nevada                        0-17378                        84-1012042
----------------               ------------                  -------------------
(State or other                (Commission                   (I.R.S. Employer
jurisdiction of                File Number)                  Identification No.)
incorporation)

                             8100 Southpark Way, B-1
                            Littleton, Colorado                   80120
               ----------------------------------------       -------------
               (Address of Principal Executive Offices)         (Zip Code)


        Registrant's telephone number including area code: (303) 794-2000
                                                           --------------


          -------------------------------------------------------------
          (Former name or former address, if changed since last report)



<PAGE>



Item 1. CHANGES IN CONTROL OF REGISTRANT
        --------------------------------

     Effective August 7, 2000 ("closing"),  Vitro Diagnostics,  Inc. ("Company,"
"us" or "we")  entered  into a number  of  agreements,  as a result  of which we
experienced  a change  in  control.  Roger D.  Hurst,  former  President,  Chief
Executive  Officer and a director of the Company,  resigned from those positions
and James R. Musick  succeeded Mr. Hurst as the  President  and Chief  Executive
Officer.  Two individuals were added to our Board of Directors,  one to fill the
vacancy  created by the resignation of Mr. Hurst and one to fill a new position.
In  addition,  certain of our  shareholders  agreed to vote common  stock of our
Company in favor of the election and retention of certain  directors,  including
the foregoing  individuals.  A more  detailed  description  of the  transactions
giving rise to this change in control is included in the balance of this report.
You should review  copies of the  agreements  executed in connection  with these
transactions,  copies of which are  attached  as exhibits  to this  report.  The
descriptions of those transactions are qualified by reference to those exhibits.

     At closing,  we sold  certain  assets  formerly  used in our  business to a
private  company  controlled by Mr. Hurst.  See Item 2 below for a more complete
description  of that  transaction.  At the same time,  Mr.  Hurst  resigned  his
position as President, Chief Executive Officer and a director of the Company. In
accordance  with the terms of a  shareholders'  agreement  executed  on the same
date, remaining members of our Board of Directors voted to increase our Board to
four individuals.  Messrs. Henry Schmerler and Ronald Goode were then elected to
fill the vacancy created by the resignation of Mr. Hurst and the vacancy created
by the  expansion of our Board.  Simultaneously,  James R. Musick,  formerly our
Vice  President  and  Secretary,  was elected as President  and Chief  Executive
Officer on an interim basis pending further consideration by our Board. Erik Van
Horn was elected Vice President and Secretary.

     The Company's  Board of Directors now includes  Ronald L. Goode,  Ph.D. and
Mr. Henry  Schmerler as outside  directors.  Dr. Goode, a former  pharmaceutical
executive,  operates a consulting  business focusing on strategic  alliances and
other collaborative  relationships within the pharmaceutical industry. Dr. Goode
has held a variety  of  executive  positions  with  major  pharmaceutical  firms
including G.D. Searle and Pfizer  Pharmaceuticals.  He was Corporate Senior Vice
President of Licensing and Business  Development of G.D. Searle and Company.  He
also served as President of Searle International Operations. In addition, he was
Vice-President of Clinical and Scientific Affairs for Pfizer Pharmaceuticals.

     Mr.  Schmerler is a former  executive with Dun and Bradstreet  Corporation,
where  he  held  various   positions   including   Vice  President  of  Business
Development, President of the National Credit Office and President of the Credit
Clearing House.  He is presently a financial  consultant and serves on the board
of a privately-held company.

                                       2

                                      -2-

<PAGE>

     Pursuant to the terms of the  shareholders'  agreement,  World Wide Capital
Investors,  LLC  ("WWC"),  the owner of  2,370,000  shares of our common  stock,
Messrs. Musick and Van Horn agreed to vote their shares such that our Board will
be  comprised  of Messrs.  Musick,  Schmerler,  Goode,  Van Horn and  William J.
Schmulh.  It is anticipated  that Mr. Schmulh will be nominated as a director in
connection with an upcoming  meeting of  shareholders.  Also in conjunction with
the  shareholders'  agreement,  Messrs.  Hurst and  Musick  granted a proxy with
regard  to  1,4000,000  shares  of our  common  stock to  Ronald  Goode or Henry
Schmerler to vote as  determined by the Board of  Directors.  The  shareholders'
agreement  represented a compromise between our existing management and WWC with
regard to the efforts of WWC to nominate and elect  certain  individuals  to our
Board of Directors and otherwise  exercise control of the Company,  as set forth
in an amendment to a Schedule 13-D filed on its behalf.

     As a result of these  transactions,  our Board is now  comprised of Messrs.
Musick, Schmerler,  Goode and Van Horn. The newest members of our Board, Messrs.
Schmerler  and  Goode,  own  150,000  and  50,000  shares of our  common  stock,
respectively.


Item 2. ACQUISITION OR DISPOSITION OF ASSETS
        ------------------------------------

     Also  effective  August  7,  2000,  pursuant  to the  terms  of a  purchase
agreement, we sold all of the assets of our antigen division to AspenBio,  Inc.,
a private  Colorado  corporation  ("purchaser")  controlled by Mr.  Hurst.  This
transaction was effective for accounting  purposes on July 31, 2000. In exchange
for the assets, the purchaser agreed to pay us $700,000 and assume a majority of
our liabilities.  At closing, we received $250,000 cash and a promissory note in
the  principal  amount of  $450,000  payable  September  7, 2000.  This note was
personally  guaranteed by Mr. Hurst. In addition,  the purchaser  assumed all of
our  liabilities  except for certain  excluded  liabilities  associated with the
business and assets which we retained.  As of the date of closing,  we estimated
that the assumed  liabilities  totaled  approximately  $600,000 on an  unaudited
basis. The purchaser  agreed to pay all of these  liabilities as they become due
and, if not sooner paid,  within ninety days of closing,  or to obtain a release
of the Company from all of those liabilities.

     The assets included in this sale were all of the assets formerly used by us
in our antigen division.  These assets include equipment,  furniture,  fixtures,
inventory, accounts receivable and intangible assets associated with the antigen
division.  These  assets  were  formerly  used by us to produce  and  distribute
antigens  primarily  for  diagnostic  purposes.  Following the sale, we retained
patents  and  other  intellectual  property  which we use or  propose  to use in
connection with a therapeutic  business.  We intend to continue that business in
the future.

     The value of the assets  transferred in this sale was based on a variety of
factors   considered  by  our  Board  of  Directors.   These  factors   included
negotiations between the parties,  historical cash flow of the assets during the
preceding  fiscal  years,  estimated  replacement  cost of  certain  assets  and
estimates of the assets  provided by third parties.  We did not find it suitable
to and did not assign relative weights to the individual  factors  considered in
reaching a  conclusion  as to the  estimated  value of the assets.  However,  we
believe that each of those factors was material to a  determination  of the sale
price.

     In connection with the purchase agreement, we agreed to indemnify Mr. Hurst
and Mr.  Hurst has  indemnified  us as to  certain  liabilities  related  to the
transaction.  The indemnification includes liabilities of the Company which were
assumed by the purchaser.


Item 5. OTHER EVENTS
        ------------

                                        3

                                       -3-

<PAGE>

     In connection  with the  compromise  with WWC and the sale of assets to the
purchaser,  we executed a settlement  agreement and mutual  release  relating to
claims  pending  between  the  parties.  Parties to the  settlement  include our
Company, purchaser, Hurst individually, WWC, Kyln Roth, a manager of WWC, Musick
and Van Horn  individually.  This agreement  releases and discharges  each party
from any and all claims  pending  between them except for those set forth in the
shareholders'  agreement,  purchase  agreement  or  other  documents  referenced
therein.

     In conjunction with the settlement agreement,  the Company and WWC executed
a  registration  rights  agreement  relating to common stock owned by WWC.  This
agreement obligates the Company to register up to 2,370,000 shares of our common
stock with the Securities and Exchange Commission upon the request of WWC and to
keep that registration  effective for a period of up to six months. We agreed to
pay  all  costs  and  expenses  in  connection  with  that  registration  except
commissions payable upon sale of the common stock by the shareholder.


Item 7. FINANCIAL STATEMENTS, PROFORMA FINANCIAL INFORMATION AND EXHIBITS
        -----------------------------------------------------------------

        (c.) Exhibits.

             10.1   Purchase   Agreement   between  Vitro   Diagnostics,   Inc.,
                    AspenBio,  Inc.  and others  dated  August 7, 2000,  without
                    Exhibits.

             10.2   Shareholders' Agreement dated August 7, 2000

             10.3   Settlement Agreement and Release dated August 7, 2000

             10.4   Registration Rights Agreement dated August 7, 2000

                                       4

                                      -4-
<PAGE>



                                    SIGNATURE

     Pursuant  to the  requirements  of  Section  13 or 15(d) of the  Securities
Exchange Act of 1934, the Registrant has duly caused this Report to be signed on
its behalf by the undersigned hereunto duly authorized.

                                 VITRO DIAGNOSTICS, INC.


                            By: /s/ James R. Musick
Date: August 22, 2000           ----------------------------------
                                    James R. Musick, President and
                                    Chief Executive Officer




                                       5

                                      -5-
<PAGE>



                                  EXHIBIT INDEX

Exhibit
Number                              Description
------
10.1.          Purchase Agreement between Vitro  Diagnostics,  Inc.,
               AspenBio, Inc. and others dated August 7, 2000, without Exhibits.

10.2           Shareholder's Agreement dated August 7, 2000

10.3           Settlement Agreement and Release dated August 7, 2000

10.4           Registration Rights Agreement dated August 7, 2000


                                       6

                                      -6-
<PAGE>



Exhibit 10.1.  Purchase Agreement between Vitro  Diagnostics,  Inc.,
               AspenBio, Inc. and others dated August 7, 2000, without Exhibits.
--------------------------------------------------------------------------------




                               PURCHASE AGREEMENT


                                      -7-

<PAGE>


                                TABLE OF CONTENTS

Section                 Title                                       Page
-------------------------------------------------------------------------

1.   Recitals.........................................................1

2.   Assets...........................................................1

3.   Assumption of Liabilities........................................1

4.   Purchase Price...................................................1

        (a)  Cash Price...............................................2

        (b)  Allocation of Price......................................2

5.   Effective Date...................................................2

6.   Agreement and Cashless Exercise..................................2

        (a)  Voting Agreement.........................................2

        (b)  Cashless Exercise........................................2

7.   Closing..........................................................2

        (a)  Certificates.............................................2

        (b)  Buyer's Legal Opinion....................................2

        (c)  Seller's Legal Opinion...................................2

        (d)  Fairness Determination...................................2

        (e)  Bill of Sale and Assignment..............................2

        (f)  List of Specific Liabilities.............................2

        (g)  Assumption of Liabilities................................3

        (h)  Payment..................................................3

        (i)  Voting Agreement.........................................3

        (j)  Release and Settlement Agreement.........................3

        (k)  Records..................................................3


                                       i

                                      -8-

<PAGE>

        (l)  Assignments of Contracts.................................3

        (m)  Insurance Policies.......................................3

        (n)  Other Acts...............................................3

        (o)  Resignation of Hurst.....................................3

8.   Representations and Warranties by Seller.........................3

        (a)  Corporate Status.........................................3

        (b)  Corporate Actions........................................3

9.   Representations and Warranties by Seller, Van Horn and Musick....4

        (a)  Financial Statements.....................................4

        (b)  Accounts Receivable and Liabilities......................4

        (c)  Inventory................................................4

        (d)  Assets...................................................4

        (e)  Specific Liabilities.....................................4

        (f)  Absence of Change........................................4

        (g)  Absence of Liens.........................................5

        (h)  Material Agreements......................................5

        (i)  Litigation...............................................5

        (j)  Insurance................................................5

        (k)  Employees................................................5

        (l)  Taxes....................................................5

        (m)  Complete Disclosure..................................... 5

10.  Representations and Warranties by the Buyer and Hurst............6

        (a)  Corporate Status.........................................6

        (b)  Corporate Actions........................................6

        (c)  No Conflicting Agreements................................6

                                       ii

                                      -9-

<PAGE>

        (d)  Litigation...............................................6

        (e)  Complete Disclosure......................................6

11.  Indemnification..................................................6

        (a)  Indemnification for Claims...............................6

        (b)  Procedures...............................................6

        (c)  Limitation on Indemnification............................7

12.  Lease............................................................8

13.  Conditions to Closing............................................8

        (a)  Seller's Conditions..................................... 8

                (i)  Compliance with Agreement........................8

                (ii) Corporate Action.................................8

                (iii)Legal Opinion....................................8

        (b)  Buyer's Conditions...................................... 8

                (i)  Compliance with Agreement........................8

                (ii) No Legal Action .................................8

                (iii)Legal Opinion....................................8

                (iv) Cashless Exercise................................8

14.  Termination......................................................8

        (a)  Right to Terminate...................................... 8

        (b)  Rights on Termination................................... 8

15.  Finder's Fees....................................................9

16.  Assignments and Assumptions......................................9

17.  Miscellaneous....................................................9

        (a)  Survival of Agreement....................................9

        (b)  Notices..................................................9

                                      iii

                                      -10-

<PAGE>

        (c)  Successors and Assigns...................................9

        (d)  Merger..................................................10

        (e)  Governing Law...........................................10

        (f)  Modification or Severance...............................10

                                       iv

                                      -11-

<PAGE>


         AGREEMENT FOR PURCHASE OF ASSETS AND ASSUMPTION OF LIABILITIES

     Vitro Diagnostics,  Inc., a Nevada corporation (the "Seller"),  Erik D. Van
Horn ("Van Horn") and James R. Musick  ("Musick")  agree with AspenBio,  Inc., a
Colorado  corporation  (the "Buyer") and Roger D. Hurst  ("Hurst") as follows in
consideration of the mutual  covenants and agreements  contained herein this 7th
day of August, 2000.

     1. Recitals. One division of the operating business of the Seller as it now
exists and as it is  intended to continue  under the  ownership  of the Buyer is
sometimes  referred to as the  "Antigen  Division."  The Seller will sell to the
Buyer, subject to the terms and conditions of this Agreement,  all of the assets
associated with the Antigen  Division  except for certain  excluded assets which
are described in Exhibit A attached hereto ("Excluded  Assets)".  The Buyer will
buy all the assets in  consideration  of a purchase price as set forth below and
in further consideration of the assumption of all of the liabilities  associated
with the Antigen Division except for certain Excluded  Liabilities.  Hurst joins
in this Agreement as the shareholder of the Buyer.

     2. Assets.  The Buyer agrees to buy, and the Seller agrees to sell, subject
to the terms and conditions  hereof,  all of the assets of the Antigen  Division
including  but not limited to those  described in Exhibit B attached  hereto but
specifically excluding the Excluded Assets (Exhibit A and Exhibit B together the
"Assets"). In addition to the Assets shown on Exhibit B, the Assets also include
all off-book assets which are used or useable in the Seller's Antigen  Division,
including all previously  expensed  supplies,  written-off  inventory,  records,
trade goodwill,  proprietary information,  and other intangible assets owned and
used by the Seller in the conduct of the Antigen Division, as well as all assets
of the Antigen  Division arising in the ordinary course of its business from and
after the date of the schedule set forth on Exhibit B.

     3. Assumption of Liabilities.  As partial consideration for the purchase of
the Assets,  the Buyer agrees to assume all of the  liabilities  associated with
the Antigen Division,  including those which arise in the ordinary course of the
Seller's  business  between  July 31, 2000 and the Closing  Date  subject to the
limitations  contained in paragraph 9(e), except for those Excluded  Liabilities
set forth on Exhibit C (the  "Excluded  Liabilities").  All of such  liabilities
except the  Excluded  Liabilities  are  hereinafter  referred to as the "Assumed
Liabilities." The Buyer agrees to pay the Assumed Liabilities as they become due
unless  Buyer in good  faith  contests  such  liabilities  with the third  party
creditor,  in which case Buyer agrees to  indemnify  the Seller for the Seller's
costs  reasonably  and  actually  incurred as a result of such  contest with the
third party creditor.  Without  limitation  Buyer and Hurst agree to pay certain
specific liabilities set forth on Exhibit D (the "Specific Liabilities") as they
become due and (2) if the Specific Liabilities are not sooner satisfied,  within
ninety  (90)  days to pay the  remaining  Specific  Liabilities  or to cause the
removal of Seller as the obligor of the Specific  Liabilities and the removal or
satisfaction  of any lien  upon  Seller's  assets  as a result  of the  Specific
Liabilities.

     4. Purchase Price. As further consideration for the purchase of the Assets,
including without limitation of Buyer's Specific  Liabilities the Buyer will pay
to the Seller the sum of $700,000. Buyer agrees to pay any sales taxes resulting
from this transaction. The purchase price will be paid as follows:


                                      -12-
<PAGE>

          (a)  Cash  Price.  The sum of  $700,000  in cash or  certified  funds,
     $250,000  of which shall be  delivered  in cash or  certified  funds by the
     Buyer at Closing, and the rest by a promissory note in the principal amount
     of  $450,000,  at 8%  interest  with  principal  and  interest  payable  by
     September 7, 2000, which note shall be personally guaranteed by Hurst.

          (b) Allocation of Price. All consideration will be allocated among the
     Assets and the other obligations of Seller as shown on Exhibit B.

     5.  Effective  Date.  The closing  will be deemed to be effective as of the
close of Seller's business on July 31, 2000.

     6. Agreement and Cashless Exercise.

          (a) Voting Agreement. Hurst agrees to subject 400,000 of his shares in
     Seller to a Voting Agreement in the form attached hereto as Exhibit E.

          (b) Cashless  Exercise.  Seller  agrees to amend the Stock Option Plan
     and to permit  employees  of  Sellers  who have  options to  exercise  such
     options through a cashless  exercise  provided that such employees agree to
     execute the Voting Agreement and a release in form and substance reasonably
     acceptable to Seller.

     7. Closing. The closing of all transactions  provided for herein will occur
at the offices of legal counsel for the Buyer on August 7, 2000.  All actions to
be taken at  closing  will be  considered  to be  taken  simultaneously,  and no
document,  agreement, or instrument will be considered to be delivered until all
items which are to be  delivered  at the  closing  have been  delivered.  At the
closing, the following actions will occur:

          (a)  Certificates.  The  Buyer  and the  Seller  each  will  execute a
     certificate  stating that all  representations  and warranties made by them
     respectively in this Agreement continue to be true at the time of closing.

          (b) Buyer's  Legal  Opinion.  The Buyer will  deliver to the Seller an
     opinion of Buyer's legal counsel, in the form attached hereto as Exhibit F.

          (c) Seller's  Legal  Opinion.  The Seller will deliver to the Buyer an
     opinion of Seller's legal counsel,  in the form attached  hereto as Exhibit
     G.

          (d)  Fairness  Determination.  Certain  stockholders  will  execute  a
     Fairness Determination in the form of Exhibit H.

          (e) Bill of Sale and  Assignment.  The Seller will execute and deliver
     to the Buyer a bill of sale and assignments,  in the form of Exhibits I, J,
     and K attached hereto,  conveying  merchantable title to all of the Assets,
     free and clear of all liens, except as permitted by paragraph 9(e).

          (f) List of Specific Liabilities. The Seller will deliver to the Buyer
     a list of all Specific  Liabilities  as of the Closing,  which list will be
     consistent with the representations and warranties of Seller herein.


                                       2

                                      -13-
<PAGE>

          (g) Assumption of  Liabilities.  The Seller and the Buyer will execute
     and  deliver to one another an  assignment  and  assumption  of all Assumed
     Liabilities  with respect to all of the Assumed  Liabilities in the form of
     Exhibit L attached hereto.

          (h) Payment.  Buyer will pay the purchase price provided for herein by
     delivering the sum of $250,000 in cash or certified  funds and a promissory
     note in the  principal  amount of $450,000 in the form  attached  hereto as
     Exhibit M. Hurst will execute and deliver a Personal  Guarantee in the form
     of Exhibit N.

          (i) Voting Agreement. The Voting Agreement in the form attached hereto
     as Exhibit E shall have been executed.

          (j) Release and Settlement Agreement.  The parties shall have executed
     the Release and Settlement Agreement in the form attached hereto as Exhibit
     O.

          (k)  Records.  The Seller  will  deliver  to the Buyer all  accounting
     records, customer lists, contracts, orders, and other documents relating to
     the  Antigen  Division,  provided  that the  Buyer  will,  however,  permit
     reasonable  access to such documents,  including  copying thereof,  for the
     purpose of permitting  the Seller to complete tax returns and conduct other
     necessary post-closing business.

          (l)  Assignments  of  Contracts.   Seller  will  execute   appropriate
     assignments  to Buyer of all  material  contracts  relating  to the Antigen
     Division,  including  assignment  of  the  confidentiality  and  employment
     agreements  of  employees,  all of  which  assignments  will be in form and
     substance satisfactory to Buyer and which will be accompanied, if necessary
     in the judgment of legal  counsel for Buyer,  with any  acknowledgement  or
     consent required by any other party to such contracts.

          (m) Insurance Policies. The Seller will cause to be transferred to the
     Buyer all of the  Seller's  insurance  policies,  as  described on Schedule
     9(j), including all deposits and credits associated therewith.

          (n)  Other  Acts.  The  parties  will  execute  any  other   documents
     reasonably  required to carry out the intent of this  Agreement,  including
     specific  transfer  documents  to be executed by the Seller with respect to
     any of the Assets which require separate documents of transfer.

          (o)  Resignation  of  Hurst.  Hurst  agrees to  execute a  resignation
     mutually acceptable to the parties.

     8.  Representations  and  Warranties by Seller.  The Seller  represents and
warrants to the Buyer as follows:

          (a)  Corporate  Status.  The Seller is duly  incorporated  and in good
     standing under the laws of the state of Nevada.

          (b)  Corporate  Actions.  All actions  required  of Seller  hereunder,
     including  the  execution  of  this  Agreement  and   consummation  of  all
     transactions  provided for herein, have been duly authorized by appropriate
     actions of its  shareholders  and  directors,  and all such  agreements and
     instruments executed pursuant thereto will be valid and enforceable against
     the Seller in accordance with the terms hereof.


                                       3

                                      -14-

<PAGE>

     9.  Representations  and Warranties by Seller,  Van Horn and Musick. To the
best of their knowledge,  the Seller, Van Horn, and Musick represent and warrant
to the Buyer as follows (the Seller's best  knowledge for the purpose of Section
9 is the best knowledge of Van Horn and Musick):

          (a) Financial Statements. The financial statements of the Seller as of
     the end of its most  recently  completed  fiscal  year  attached  hereto as
     Schedule 9(a) (the "Audited  Statements")  have been prepared in accordance
     with generally accepted accounting principles  consistently applied and are
     true and  correct in all  material  respects as of the dates  thereof.  The
     Audited Statements are collectively  referred to as the "Seller's Financial
     Statements."  There has not been and will be no material  adverse change in
     the Seller's  financial  condition or its business or  operations  from the
     date of April 30, 2000 through the date of Closing,  except those  incurred
     in the ordinary course of business.

          (b) Accounts Receivable and Liabilities. The accounts receivable shown
     on the Seller's  Financial  Statements  and all other  accounts  receivable
     arising from and after the date of the Financial  Statements have arisen in
     the  ordinary  course of Seller's  business.  The amounts of such  accounts
     receivable,  as  of  the  dates  on  Seller's  Financial  Statements,   are
     substantially  true and correct.  All liabilities have arisen or will arise
     in the ordinary course of the Antigen Division, and all of such liabilities
     can be satisfied by payment in full of the amounts  thereof in a manner and
     on a  schedule  consistent  with  Seller's  past  practices  as  previously
     disclosed  to  Buyer.  Seller  agrees  not  to  interfere  in  the  Buyer's
     collection of the accounts receivable.

          (c)  Inventory.  All  of the  inventory  of the  Seller  shown  on the
     Seller's Financial Statements as of the dates thereof was in the possession
     of Seller  and has been  valued  and will be valued at the lower of cost or
     fair market value.

          (d) Assets.  The Assets constitute all of the property,  including for
     example,  intangible  technology  and  know-how,  which are now used in the
     Antigen  Division.  The Assets are adequate and appropriate for the conduct
     of  the  Antigen  Division  as now  conducted.  The  Seller  has  good  and
     merchantable   title  to  all  the  Assets,   subject  only  to  liens  and
     encumbrances  shown in  Schedule  9(e),  all of which are to be assumed and
     paid when and as due by the  Buyer.  All  Assets are sold "as is" after due
     inspection and  examination by the Buyer,  and the warranties  made in this
     Agreement  are in lieu of all  other  warranties,  including  any  warranty
     implied by law, all of which are expressly excluded.

          (e) Specific  Liabilities.  The Specific  Liabilities include only the
     liabilities shown in Exhibit D. Seller has not incurred any liability other
     than the Assumed Liabilities and the Excluded Liabilities.

          (f) Absence of Change.  There has been and will be no material adverse
     change in the nature of the Seller's  operations or the value of the Assets
     from and after the date of the Interim Financial  Statements through August
     7, 2000.

                                       4

                                      -15-

<PAGE>

          (g) Absence of Liens. The Assets will be transferred free and clear of
     any lien or claim of any nature  including liens for taxes,  except for (i)
     sales or use taxes arising from the sale hereunder,  which the Buyer agrees
     to pay and (ii) the Assumed Liabilities.

          (h) Material  Agreements.  Schedule 9(h) is a true and correct list of
     all material contracts, leases, and other agreements to which the Seller is
     a party,  all of which will be assigned at Closing to Buyer.  The Seller is
     not in  violation  of any  such  agreement,  nor  will  the  execution  and
     consummation of this Agreement,  including the assignment of the agreements
     listed in Schedule  9(h) to the Buyer,  cause any breach of any contract or
     acceleration  or material change in any obligation of the Seller which will
     affect the  Antigen  Division  or the  Assets  except  with  respect to the
     Specific Liabilities.

          (i) Litigation.  The Seller is not a party to any  litigation,  nor to
     the best  knowledge of Seller,  is any  litigation  threatened  or pending,
     except as shown in Schedule 9(i) attached  hereto.  The Seller is not aware
     of any set of facts or  circumstances  which  would  give rise to any claim
     materially  affecting the Antigen Division or the authority of the Buyer to
     consummate the transactions provided for herein.

          (j) Insurance.  The Seller has maintained full and adequate  insurance
     with respect to the operation of the Antigen Division.  All of the Seller's
     insurance  policies,  including  the name of the  carrier and the amount of
     coverage,  are accurately  and  completely  shown on Schedule 9(j) attached
     hereto.  All such  insurance will remain in effect through August 15, 2000,
     and all of such  insurance  may be assumed by the Buyer at the  election of
     the Buyer.

          (k)  Employees.  Schedule 9(k)  attached  hereto sets forth a complete
     list of the employees of the Seller,  the rate of compensation of each, and
     all benefits  applicable to each such  employee.  The Seller has previously
     delivered to the Buyer a copy of the  Seller's  standard  employee  manual,
     setting  forth  other  employee  policies,  all of which  remain  in effect
     without  change or addition and will  continue to remain in effect  through
     Closing.  The  Seller  has no  agreements  with any  employee  or any other
     obligation to any employee except as set forth in Schedule 9(k). The Seller
     is not subject to any pending or  threatened  labor  disputes.  None of the
     Seller's  employees are  represented  by a labor union or other  collective
     bargaining  unit,  nor is the Seller  aware of any effort to  organize  the
     employees of the Seller.

          (l) Taxes. The Seller has timely and correctly  prepared and filed all
     tax returns,  including  federal and state income tax returns and sales tax
     returns, and the Seller has paid all taxes due pursuant to such tax returns
     as well as any other taxes,  including real and personal property taxes for
     which the Seller is liable,  except for  certain  property  taxes which are
     accrued  but not yet due,  as shown in detail  on  Schedule  9(l)  attached
     hereto.  The  Seller  has  not  filed  for and is not  now  subject  to any
     extension of time with respect to the filing of any tax return.  The Seller
     has provided to the Buyer true and correct  copies of all federal and state
     income tax returns filed by the Seller for the past three fiscal years. The
     Seller is not aware of any actual or threatened tax audit nor of any set of
     facts  which  would give rise to any tax audit.  The  financial  statements
     reflect an adequate reserve,  as of the date thereof,  for income taxes now
     due for the present tax year. The Seller maintains all required payroll tax
     accounts,  and the Seller has timely  deposited  all  employee and employer
     withholding taxes into such trust accounts.


                                       5

                                      -16-

<PAGE>

          (m) Complete Disclosure. This Agreement and the exhibits and schedules
     thereto do not  contain  any  untrue  statement  of a material  fact by the
     Seller;  this Agreement and such related  agreements and instruments do not
     omit to state any material fact  necessary in order to make the  statements
     made herein or therein,  in the light of the circumstances under which they
     are made, not misleading.

     10.  Representations  and Warranties by the Buyer and Hurst.  The Buyer and
Hurst  represent and warrant as follows:

          (a) Corporate Status. The Buyer is a corporation duly incorporated and
     existing in good standing under the laws of the state of Colorado.

          (b) Corporate  Actions.  All transactions  provided for herein and all
     obligations  of the Buyer related  hereto have been duly  authorized by all
     requisite corporate action, and all agreements entered into,  including the
     execution and consummation of this Agreement and all exhibits hereto,  will
     be valid and fully  enforceable  against the Buyer in  accordance  with the
     terms thereof.

          (c)  No  Conflicting  Agreements.  The  Buyer  is not a  party  to any
     contract,  agreement, or other obligation which is in default or which will
     become in default or  subject to any  acceleration  or penalty by reason of
     the execution and consummation of this Agreement.

          (d)  Litigation.  The Buyer is not subject to any  litigation or other
     claim,  including  any  governmental  investigation,  actual,  pending,  or
     threatened, to the best of their respective knowledge.

          (e) Complete Disclosure. This Agreement and the exhibits and schedules
     thereto do not  contain  any  untrue  statement  of a material  fact by the
     Buyer;  this Agreement and such related  agreements and  instruments do not
     omit to state any material fact  necessary in order to make the  statements
     made herein or therein by the Buyer,  in light of the  circumstances  under
     which they are made, not misleading.

     11.  Indemnification.  The parties hereto agree to indemnify one another as
follows:

          (a)  Indemnification  for Claims.  As used herein,  the term  "Claims"
     refers to any losses,  damages,  liabilities,  or claims including costs or
     expenses  (including but not limited to attorneys'  fees and other expenses
     of  investigation in defense of any such claims) which arise as a result of
     any  breach  or  violation  of  the  covenants,  agreements,  warrants,  or
     representations  contained  in this  Agreement  or to which  Roger Hurst is
     subject as a result of his service as an officer and  director of Seller to
     the extent permitted by law. Any party who must indemnify for a Claim shall
     be referred to as an "Indemnifying Party" and any party who has suffered or
     is threatened  with suffering  losses in connection with such a Claim shall
     be referred to as an "Indemnified  Party." The  Indemnifying  Party will be
     obligated  to  indemnify  the  Indemnified  party with respect to any Claim
     occasioned  by a breach or  violation of this  Agreement  or any  ancillary
     agreement on the part of the Indemnifying Party.


                                       6

                                      -17-
<PAGE>

          (b) Procedures.

               (i) Promptly after an Indemnified Party has received notice of or
          has  knowledge of any claim by a person not a party to this  Agreement
          (a "Third Person") or the  commencement of any action or proceeding by
          a Third Person, the Indemnified Party shall, as a condition  precedent
          to a claim with respect  thereto  being made  against an  Indemnifying
          Party, give the Indemnifying Party written notice of such claim or the
          commencement of such action or proceeding (the "Notice of Claim"). The
          Notice of Claim shall state the nature and the basis of such claim and
          a reasonable estimate of the amount thereof.

               (ii) The  Indemnifying  Party  shall  have  right to  defend  and
          settle, at its own expense and by its own counsel,  any such matter so
          long as the  Indemnifying  Party  pursues  the same in good  faith and
          diligently.  If the Indemnifying Party undertakes to defend or settle,
          it shall notify the Indemnified Party of its intention to do so within
          seven (7)  calendar  days of  receiving  the Notice of Claim,  and the
          Indemnified Party shall cooperate with the Indemnifying  Party and its
          counsel in the defense  thereof and in any  settlement  thereof.  Such
          cooperation shall include, but shall not be limited to, furnishing the
          Indemnifying Party with any books,  records or information  reasonably
          requested  by the  Indemnifying  Party  that  are  in the  Indemnified
          Party's  possession or control.  Notwithstanding  the  foregoing,  the
          Indemnified  Party shall have the right to  participate  in any matter
          through counsel of its own choosing at its own expense;  provided that
          the  Indemnifying  Party's  counsel  shall  always be lead counsel and
          shall determine all litigation and settlement steps,  strategy and the
          like. After the Indemnifying  Party has notified the Indemnified Party
          of its  intention to  undertake to defend or settle any such  asserted
          liability,  and  for so  long  as the  Indemnifying  Party  diligently
          pursues such defense,  the Indemnifying  Party shall not be liable for
          any additional  legal expenses  incurred by the  Indemnified  Party in
          connection with any defense or settlement of such asserted  liability,
          except as provided  below and except to the extent such  participation
          is requested by the Indemnifying Party, in which event the Indemnified
          Party shall be reimbursed  by the  Indemnifying  Party for  reasonable
          additional legal expenses, out-of-pocket expenses.

               (iii) The  Indemnifying  Party  shall not, in the defense of such
          asserted liability,  consent to the entry of any judgment or award, or
          enter  into any  settlement,  except  in either  event  with the prior
          consent of the  Indemnified  Party,  which  shall not be  unreasonably
          withheld or delayed.  If the  Indemnifying  Party  desires to accept a
          final and complete  settlement of any such Third Person claim in which
          no admission  of material  wrongdoing  is required of the  Indemnified
          Party and the Indemnified Party refuses to consent to such settlement,
          then the  Indemnifying  Party's  liability  under this Section 11 with
          respect to such Third  Person  claim shall be limited to the amount so
          offered in settlement by said Third Person,  and the Indemnified Party
          shall  reimburse the  Indemnifying  Party for any additional  costs of
          defense which it  subsequently  incurs with respect to such claim.  If
          the  Indemnifying  Party does not  undertake  to defend such matter to
          which the Indemnified Party is entitled to indemnification  hereunder,
          or fails diligently to pursue such defense,  the Indemnified Party may
          undertake such defense through counsel of its choice,  at the cost and
          expense  of the  Indemnifying  Party,  and the  Indemnified  Party may
          settle such matter,  and the  Indemnifying  Party shall  reimburse the
          Indemnified Party for the amount paid in such settlement and any other
          liabilities  or  expenses   incurred  by  the  Indemnified   Party  in
          connection therewith.

          (c) Limitation on Indemnification.  No claim for indemnification shall
     be made hereunder  until the aggregate  amount of actual or probable losses
     of any Indemnified Party subject to  indemnification  from the Indemnifying
     Party  equals or exceeds the sum of $25,000.  Nonetheless,  an  Indemnified
     Party may provide an Indemnifying  Party with notice of Claims of less than
     $25,000 as provided  for in Section  11(a) and may permit the  Indemnifying
     Party to defend, settle, or otherwise resolve such claims in order to avoid
     having the aggregate amount for which such Indemnifying Party may be liable
     exceed $25,000.

                                       7

                                      -18-

<PAGE>


     12.  Lease.  The Antigen  Division is  presently  conducted on the premises
subject to a lease with First  Industrial LP (the  "Lease").  The Lease shall be
assigned to, and assumed by, the Buyer.

     13.  Conditions  to Closing.  The  obligations  of the parties to close the
transactions provided for herein are subject to the following conditions as well
as to any other conditions express or implied in this Agreement:

          (a) Seller's Conditions.  The obligations of the Seller are subject to
     the following conditions:

               (i) Compliance with Agreement.  All representations,  warranties,
          covenants,  and other  agreements  contained herein on the part of the
          Buyer will be true and correct at the time of Closing.

               (ii)  Corporate  Action.  The sale will have been approved by all
          requisite corporate action by the Seller.

               (iii) Legal  Opinion.  The Seller will have  received a favorable
          opinion of Buyer's legal counsel in the form required by Section 7(b).

          (b) Buyer's  Conditions.  The obligations of the Buyer to complete the
     transactions provided for herein are subject to the following conditions:

               (i) Compliance with Agreement.  All representations,  warranties,
          covenants  and other  agreements  contained  herein on the part of the
          Seller will be true and correct at closing.

               (ii)  No  Legal  Action.   No  investigation  or  action  by  any
          governmental  regulatory agency having jurisdiction over the Seller or
          the  Assets  will have been  commenced  which will  interfere  with or
          jeopardize the ability of the Buyer to acquire the Assets and continue
          conducting the Antigen Division.

               (iii)  Legal  Opinion.  The Buyer will have  received a favorable
          opinion of  Seller's  legal  counsel in the form  required  by Section
          7(c).

               (iv)  Cashless  Exercise.  The Seller  shall amend the 1992 Stock
          Option Plan to permit a cashless exercise.

     14. Termination.

          (a) Right to Terminate.  This  Agreement may be terminated at any time
     by mutual  agreement of the parties or it may be terminated by the party in
     whose favor a condition  runs upon a failure of such condition as set forth
     in Section 13 to be satisfied in full.


                                       8

                                      -19-
<PAGE>

          (b) Rights on Termination.  If this Agreement  terminates  pursuant to
     Section  14(a) for any reason  other than a willful  failure to satisfy the
     conditions set forth in Section 13, this  Agreement will terminate  without
     liability to either party and each party will,  upon such  termination,  be
     responsible for its own expenses incurred in connection herewith.

     15. Finder's Fees.  Each of the parties  represents and warrants to each of
the  other  parties  that it has  not  incurred  any  obligation  for any  sales
commission,  brokerage  fee,  finder's  fee,  or  other  similar  obligation  in
connection with the transactions provided for herein.

     16. Assignments and Assumptions. Seller and Buyer shall cooperate to obtain
the  assignment and assumption  agreement of the material  agreements  listed in
Schedule 9(h) and the Specific Liabilities.

     17. Miscellaneous.

          (a) Survival of Agreement.  This Agreement and all terms,  warranties,
     and  provisions  hereof  will be true and correct as of the time of closing
     and will survive the closing.  All representations and warranties and other
     obligations  of the parties  hereunder will continue in effect for a period
     of two (2) years.

          (b) Notices.  All notices required or permitted hereunder or under any
     related  agreement or instrument  will be deemed  delivered  when delivered
     personally or mailed,  by certified  mail,  return  receipt  requested,  or
     registered  mail,  to the  parties at the  following  addresses  or to such
     addresses as the respective parties may in writing hereafter direct:

               (i) To Seller:

                   8100 Southpark Way, B-1
                   Littleton, CO  80120

                   with a copy to:

                   Overton Babiarz & Associates, PC
                   7720 E. Belleview Avenue, Suite 200
                   Englewood, CO  80111
                   Attention:  David J. Babiarz, Esq.

               (ii) To Buyer:

                    8100 Southpark Way, B-1
                    Littleton, CO  80120

                    with a copy to:

                    Krendl Krendl Sachnoff & Way
                    370 Seventeenth Street, Suite 5350
                    Denver, CO  80202
                    Attention:  Cathy S. Krendl, Esq.


                                        9

                                      -20-
<PAGE>

          (c)  Successors  and Assigns.  This Agreement will be binding upon the
     parties hereto and their respective successors,  personal  representatives,
     heirs and assigns;  however,  no party hereto will have any right to assign
     any of its  obligations  pursuant to this  Agreement  except with the prior
     written consent of all of the other parties.

          (d)  Merger.  This  Agreement  and the  Exhibits  and other  documents
     related  hereto set forth the entire  agreement of the parties with respect
     to the subject  matter hereof and may not be amended or modified  except in
     writing subscribed to by all of such parties.

          (e)  Governing  Law.  This  Agreement  is entered into in the city and
     county of Denver,  state of  Colorado,  it will be performed in part within
     the city and county of Denver,  and it will be governed in all  respects by
     the laws of Colorado.

          (f) Modification or Severance. In the event that any provision of this
     Agreement   is  found  by  any  court  or  other   authority  of  competent
     jurisdiction to be illegal or unenforceable, such provision will be severed
     or modified to the extent  necessary  to render it  enforceable,  and as so
     severed or modified, this Agreement will continue in full force and effect.

         Dated the day and year first above set forth.


VITRO DIAGNOSTICS, INC.                    ASPENBIO, INC.



By: /s/ James R. Musick                   By:  /s/ Roger D. Hurst
    ----------------------------------         ---------------------------------
       James R. Musick, Vice President                 Roger D. Hurst, President


    /s/ James R. Musick                       /s/ Roger D. Hurst
    ----------------------------------        ----------------------------------
        James R. Musick                           Roger D. Hurst


    /s/ Erik D. Van Horn
    ----------------------------------
        Erik D. Van Horn

                                       10

                                      -21-
<PAGE>

           VITRO DIAGNOSTICS/ASPEN BIO LIST OF EXHIBITS AND SCHEDULES

                                    EXHIBITS

A.   Excluded Assets

B.   Assets and Allocation of Price

C.   Excluded Liabilities

D.   Specific Liabilities

E.   Voting Agreement

F.   Buyer's Legal Opinion Letter

G.   Seller's Legal Opinion Letter

H.   Fairness Determination

I.   Assignment and Bill of Sale

J.   Assignment and Assumption of Lease Agreement

K.   Intellectual Property Assignment Agreement

L.   Assumption Agreement

M.   Promissory Note

N.   Personal Guarantee

O.   Release and Settlement Agreement


                                    SCHEDULES

9(a) Audited Statements

9(a) (i) Interim Financial Statements

9(e) List of Liens

9(h) List of Material Contracts

9(i) Litigation

9(j) List of Insurance Policies

9(k) Employees and Benefits



                                      -22-
<PAGE>

           Exhibit 10.2 Shareholder's Agreement dated August 7, 2000
--------------------------------------------------------------------------------


                             SHAREHOLDERS' AGREEMENT

     THIS  SHAREHOLDERS'  AGREEMENT  (the  "Agreement"),  is entered into by and
between the undersigned  directors and shareholders of Vitro  Diagnostics,  Inc.
(the "Company"), (collectively "Shareholders" and individually a "Shareholder"),
effective as of August 7, 2000. The Shareholders are more particularly described
in Schedule A attached hereto and incorporated by reference herein.

                                    RECITALS

     WHEREAS,  the Shareholders are the registered and beneficial  owners of the
number of shares of common stock set forth  opposite their  respective  names on
Schedule  A,  except  that  Erik  Van  Horn  ("Van  Horn")  is not  currently  a
Shareholder  of the  Company,  but is a  party  to  this  Agreement  because  he
exercises  control  as a  Director  and is a  beneficial  owner as the holder of
significant stock options of the Company; and

     WHEREAS,  the  Shareholders  desire to cooperate to further the business of
the Company by electing an expanded  Board of  Directors,  by adding  additional
experience and expertise to the Board,  and by taking such other action as is in
the best interest of all of the Shareholders of the Company; and

     WHEREAS,  the  Shareholders  are entering into this Agreement in connection
with the sale of certain  assets of the  business to AspenBio,  Inc.  ("Buyer"),
(the "Asset Sale"),  the resignation  from the Board of Directors by Roger Hurst
("Hurst"),  the  modification  of the  number of  Directors  on the Board by the
Company,  and the  appointment to the Board of the Company of Henry C. Schmerler
and Ronald L. Goode.

     NOW THEREFORE,  in consideration of the Recitals,  which shall be deemed to
be  a  substantive  part  of  this  Agreement,  and  the  covenants,   promises,
agreements,  representations  and warranties  contained in this  Agreement,  the
Shareholders hereby covenant, promise, agree, represent and warrant as follows:

1.   Resignation of Hurst and Election of New Directors.
     ---------------------------------------------------

     1.1  Hurst has agreed to resign as a director  and  officer of the  Company
          simultaneously  with and  effective  upon  closing  of the Asset  Sale
          ("Closing"),  and the Board of  Directors  of the Company  immediately
          following Closing shall be comprised of James R. Musick ("Musick") and
          Van Horn.

     1.2  Also  effective  upon the  Closing,  Musick and Van Horn,  as the sole
          remaining  members of the Board,  have executed the Unanimous  Written
          Consent  Resolution in Lieu of Meeting  attached hereto as Schedule B,
          whereby the Board of the Company,  in accordance with its Bylaws, has:
          (a)  increased  to four (4) the  number of  directors  to serve on the
          Board;  and (b) elected  Henry  Schmerler and Ronald Goode to serve as
          members  of the Board for a term of office  continuing  until the next
          annual  meeting  by the  Shareholders;  and  (c)  approved  Musick  as
          President of the Company.


                                      -23-
<PAGE>

     1.3  As soon as practical after Closing, but in no event later than 30 days
          after  Closing,  Musick shall call a special  meeting of the Board for
          the  purpose  of: (a)  calling or  rescheduling  a special  meeting or
          annual  meeting  of   Shareholders  to  elect  a  slate  of  directors
          consisting  of:  Musick,  Van Horn,  William J.  Schmulh,  Jr.,  Henry
          Schmerler  and Ronald  Goode;  provided,  however,  that this slate of
          directors shall at all times be willing and able to serve on the Board
          of  Directors;  and  (b)  completing  the  Company's  application  for
          Director  and Officer  liability  insurance  for Henry  Schmerler  and
          Ronald Goode.

     1.4  Musick and VanHorn further agree that they shall call a meeting of the
          Board for the purpose of causing  the Company to take such  additional
          action  as may be  necessary  to:  (a)  expand  the  Board to five (5)
          directors,  and (b) elect  William J.  Schmulh to fill the  additional
          vacancy  created  thereby;  provided,  however,  that:  (a) World Wide
          Capital  Investors,  LLC ("WWC") shall have provided written notice to
          the Board of its request for the Board meeting described  herein,  and
          (b)  that WWC  shall  agree  to pay the  expenses  of any SEC or other
          regulatory  notice  required  in  connection  with such  action of the
          Board, and (c) such action shall not cause Musick or Van Horn to be in
          violation of any legal requirement or duty.

2.   Voting Agreement - Shareholders
     -------------------------------

          Beginning with execution of this Agreement,  and for a period of three
     years thereafter, the Shareholders,  with the exception of Hurst, agree and
     shall  vote all  shares  they own now or may  acquire  in the future at any
     meeting of Shareholders or consent in lieu of any meeting, as follows:

     2.1  To elect Musick,  Van Horn,  William J. Schmulh,  Jr., Henry Schmerler
          and Ronald Goode, as and for the Directors of the Company,  comprising
          the Board of Directors;

     2.2  Not to  increase  the  members of the Board of  Directors  without the
          unanimous consent of the Shareholders;

     2.3  Following the election of Musick, Van Horn,  William J. Schmulh,  Jr.,
          Henry  Schmerler  and Ronald  Goode,  the  Shareholders  shall take no
          action to remove any of the  Directors  from the Board during the term
          of this Agreement,  except that a Director may be removed for fraud or
          breach  of  fiduciary  duty,  which  determination  shall  be  made by
          majority vote of the remaining directors  following  consultation with
          independent counsel to the Company;

     2.4  Should a Director resign or be removed or a vacancy  otherwise  occur,
          the Shareholders  agree to vote their shares in favor of the candidate
          nominated by the remaining Board to fill the vacancy; and

     2.5  Subject  to review  and  approval  by the Board  elected  pursuant  to
          paragraph  1  hereof,   to  approve  the  Equity  Incentive  Plan  for
          employees,  officers,  directors,  consultants  and  others  providing
          service to the  Company in the form  proposed  by Musick and Van Horn,
          with  such  amendments  as may be deemed  appropriate  by the Board of
          Directors with the approval of counsel to the Company.

                                        2

                                      -24-
<PAGE>

3.   Grant of Proxy - Certain Shareholders
     --------------------------------------

     3.1  Simultaneous  with Closing of the Asset Sale, each of Hurst and Musick
          shall  deliver to Ronald L. Goode or Henry C.  Schmerler  (the  "Proxy
          Holder") a duly executed  irrevocable  proxy (each,  a "Proxy") in the
          form  attached  hereto as Schedule C, with  respect to voting stock of
          the  Company  owned  or  controlled  by each  Hurst  and  Musick  in a
          cumulative  amount  not to  exceed  1.4  million  shares  (the  "Proxy
          Shares"). The Proxy Shares shall initially consist of 1,000,000 shares
          owned by Musick and  400,000  shares  owned by Hurst.  The term of the
          Proxy  shall be for  eleven  months  from the date of this  Agreement,
          through July 7, 2001.  If the Proxy Holder  becomes  incapacitated  or
          dies during the term of the Proxy,  Hurst and Musick  agree to execute
          an additional proxy in the form of Exhibit C and deliver to William J.
          Schmulh  which  shall  remain in effect for the balance of the term of
          the Proxy.

     3.2  If at any time  during  the term of the  Proxy,  any  employee  of the
          Company,  including  Musick or Van Horn,  shall exercise  (additional)
          stock options for common stock of the Company and such employee  shall
          agree to grant a Proxy in the form of Schedule C for said shares, then
          the Proxy  granted by Musick  shall  abate one for one with each share
          for which a Proxy is granted by an  employee.  Van Horn agrees that he
          shall grant a Proxy  pursuant to this  section upon the exercise of up
          to 250,000 options held by him.

     3.3  Hurst,  Musick and Van Horn,  as  applicable,  agree not to revoke the
          grant of the Proxy for the term thereof.

4.   Endorsement on Stock Certificates
     ---------------------------------

          Upon  the  execution  of  this  Agreement,   the  Shareholders   shall
     temporarily  surrender their stock certificates  representing Company stock
     to the Company and the Company shall cause the following  endorsement to be
     placed thereupon before returning such certificates:

          THE RIGHT OF SALE, ASSIGNMENT,  TRANSFER, ENCUMBRANCE,  PLEDGE, OR ANY
          OTHER   DISPOSITION  OF  THE  SHARES  OF  STOCK  REPRESENTED  BY  THIS
          CERTIFICATE IS RESTRICTED BY, AND SUBJECT TO, THE TERMS AND PROVISIONS
          OF AN AGREEMENT DATED AUGUST 7, 2000.

          A COPY  OF  THIS  AGREEMENT  IS ON  FILE  WITH  THE  SECRETARY  OF THE
          CORPORATION AND AVAILABLE FOR INSPECTION UPON REQUEST.

          THE VOTING OF THE SHARES REPRESENTED HEREBY IS SUBJECT TO THE TERMS OF
          THE SAME AGREEMENT.

The following  endorsement  shall be placed upon the  certificates  of Hurst and
Musick:

                                        3

                                      -25-
<PAGE>

          THE VOTING POWER OF THE SHARES  EVIDENCED  HEREBY HAS BEEN  PREVIOUSLY
          GRANTED  TO RONALD L.  GOODE OR  WILLIAM  J.  SCHMULH,  PURSUANT  TO A
          WRITTEN PROXY EFFECTIVE AUGUST 7, 2000, WHICH PROXY IS IRREVOCABLE.

All certificates representing shares of Stock issued to or acquired by any other
Shareholder,  whether  party to this  Agreement or not,  subsequent  to the date
hereof shall, if the recipient thereof agrees to or is required to grant a Proxy
pursuant to the terms  hereof,  bear the above  legends.  The  legends  shall be
removed upon request of the Shareholder after the term of the Agreement expires.

5.   Term.
     -----
          This  Agreement  shall extend for the terms set forth  herein,  unless
     sooner terminated by the unanimous  agreement of all Shareholders or unless
     51% of the stock of the Company is acquired by a third party in a merger or
     tender offer or the Company sells all or substantially all of its assets.

6.   Remedies.
     ---------
          The  Shareholders  agree that they will not have an adequate remedy at
     law for the breach of this Agreement.  Accordingly,  the Shareholders shall
     have  available  for any breach of this  Agreement the remedies of specific
     performance and injunctive relief,  together with all other remedies at law
     and in  equity.  No  waiver  of or  forbearance  to  enforce  any  right or
     provision  hereto  shall be  binding  unless in  writing  and signed by the
     Shareholder to be bound,  and no such waiver or forbearance in any instance
     shall  apply to any other  instance or any other  right or  provision.  The
     prevailing Shareholder in any litigation or dispute shall be entitled to an
     award of reasonable attorneys fees, costs and expenses.

7.   General Provisions.
     -------------------

     7.1  Entire Agreement.
          -----------------
               This   Agreement   and  the  Exhibits   incorporated   herein  or
          incorporated  by  reference  in  any  exhibit  constitute  the  entire
          understanding of the Shareholders  with regard to this Agreement which
          includes  that  certain  Purchase  Agreement by and among the Company,
          Musick, Van Horn, AspenBio and Hurst of even date hereof,  under which
          the Company has agreed to sell to  AspenBio,  Inc. all of the "Assets"
          of the Antigen  Division of the  Company_(as  defined in the  Purchase
          Agreement).  There  are  no  representations,   promises,  warranties,
          covenants or undertakings other than those expressly set forth herein.
          No modification or amendment of this Agreement shall be binding unless
          executed in writing by all Shareholders.

     7.2  Assignment, Successor and Assigns.
          ----------------------------------
               This Agreement  shall inure to the benefit of and be binding upon
          the  Shareholders  and  their  respective   successors  and  permitted
          assigns.

     7.3  Authority.
          ----------
               The individuals  whose  signatures  appear below on behalf of the
          respective  parties to this Agreement  warrant and represent that they
          have  full  authority  to  execute  this  Agreement  on  behalf of the
          respective parties and to bind the parties to the terms and provisions
          of this Agreement.

                                        4

                                      -26-
<PAGE>


     7.4  Notices.
          --------
               Notices  required or authorized  hereunder  shall be deemed given
          sufficiently if in writing and delivered in person, sent by registered
          or certified mail, return receipt requested and postage prepaid, or by
          facsimile to the addresses on record with the Company unless and until
          the Company is notified of any change of address.

     7.5  Severability.
          -------------
               In the event that one or more of the provisions of this Agreement
          shall  be  invalid,  illegal  or  unenforceable  in any  respect,  the
          validity,  legality and  enforceability  of the  remaining  provisions
          contained herein shall not in any way be affected or impaired thereby.

     7.6  Waivers.
          --------
               No waiver of any  provision of this  Agreement  shall be deemed a
          waiver of any other provision,  nor shall any single waiver constitute
          a continuing waiver. The failure of any Shareholder as to seek redress
          for violation of, or as to insist upon the strict  performance  of any
          covenant  or  condition  of  this  Agreement,   shall  not  prevent  a
          subsequent  act which would have  originally  constituted a violation,
          from having the effect of an original violation.

     7.7  Time of Essence.
          ----------------
               Time is of the essence of each provision of the Agreement.

     7.8  Governing Law.
          --------------
               This Agreement  shall be governed by and interpreted and enforced
          in accordance  with the laws in force in the State of Colorado.  Venue
          for any action shall lie in the Courts of Colorado.

     7.9  Counterparts and Facsimiles.
          ----------------------------
               This Agreement may be executed in several counterparts, and as so
          executed shall  constitute one Agreement,  binding on all Shareholders
          hereto,  notwithstanding that all Shareholders are not signatory as to
          one  original  or  the  same  counterpart.  Facsimile  signatures  are
          acceptable.

     IN WITNESS  WHEREOF,  the  Shareholders  hereto have executed and delivered
this Agreement, on the date first above written.


SHAREHOLDERS:


/s/ Roger D. Hurst
---------------------------------
    Roger D. Hurst


/s/ James R. Musick
---------------------------------
    James R. Musick


/s/ Erik Van Horn
---------------------------------
    Erik Van Horn


                                        5

                                      -27-
<PAGE>


/s/ Kilyn Roth
---------------------------------
Kilyn Roth, Manager
World Wide Capital Investors, LLC

                                        6

                                      -28-
<PAGE>

                    Schedule A to the Shareholders' Agreement

Name and Address
of Shareholder or                                Number of Shares
Beneficial Owner                                 (including Option Shares)


Roger D. Hurst                                          1,116,793



James R. Musick                                         1,332,198



Erik Van Horn                                             530,516



World Wide Capital Investors, LLC                       2,370,000

                                        7

                                      -29-
<PAGE>



                    Schedule B to the Shareholders' Agreement
                    -----------------------------------------

                   IRREVOCABLE PROXY COUPLED WITH AN INTEREST

1.   The undersigned  shareholder (the  "Shareholder"),  holder of the number of
     shares of common  stock,  par value $.001 per share  ("Common  Stock"),  of
     Vitro  Diagnostics,  Inc.,  a Nevada  corporation,  set forth  opposite the
     Shareholder's  signature (the "Proxy Shares"),  hereby irrevocably appoints
     and  constitutes  Henry Schmerler or Ronald Goode as his attorney and proxy
     ("Proxy") to attend meetings,  vote, give consents and in all other ways to
     act in the  Shareholder's  place and stead as to all of the Proxy Shares as
     long as this Irrevocable Proxy is in effect. Proxy shall have full power of
     substitution  and  revocation and any proxies  heretofore  given are hereby
     revoked.

2.   This Irrevocable Proxy is made  irrevocable,  is subject to and executed in
     connection with a voting  agreement with the  Shareholder  embodied in that
     certain  Shareholders'   Agreement,   dated  as  of  August  7,  2000  (the
     "Shareholders'  Agreement"),   among  the  Shareholder  and  certain  other
     shareholders of the Company.

3.   Proxy  shall vote the Proxy  Shares  under this  Irrevocable  Proxy only in
     accordance  with a  resolution  of the Board of  Directors  of the  Company
     pursuant  to a vote  of  the  Board  on  any  matter  requiring  a vote  of
     shareholders of the Company.

4.   This Irrevocable  Proxy shall terminate eleven months from the date hereof,
     unless  earlier  terminated by agreement of the  Shareholders  party to the
     Shareholders'  Agreement  or  unless  51% of the  stock of the  Company  is
     acquired by a third party in a merger or tender offer or the Company  sells
     all or substantially all of its assets.


Dated:
      -------------------------



-------------------------------                --------------------------------
Shareholder                                    Number of Shares of Common Stock
                                               Subject to this Irrevocable Proxy


ACCEPTED AND AGREED TO:

-------------------------------
Proxy Holder

                                       8

                                      -30-

<PAGE>

       Exhibit 10.3 Settlement Agreement and Release dated August 7, 2000
--------------------------------------------------------------------------------



                                    EXHIBIT O

                              SETTLEMENT AGREEMENT

                               AND MUTUAL RELEASE

     THIS SETTLEMENT AGREEMENT AND MUTUAL RELEASE  ("Agreement") is entered into
effective  this 7th day of August,  2000,  between  Vitro  Diagnostics,  Inc., a
Nevada corporation ("Company"), AspenBio, Inc., a Colorado corporation, James R.
Musick  (an  individual),   Erik  VanHorn  (an  individual),   Roger  Hurst  (an
individual) ("Hurst"), and World Wide Capital Investors, LLC, a Colorado limited
liability  company  ("WWC"),  and Kilyn Roth, an individual  and manager of WWC,
collectively referred to as "Parties."


1.   Recitals.
     --------
     (a)  Commencing in May, 2000, WWC threatened a lawsuit against the Company,
          alleging  various  claims  against  the  Company  and  certain  of its
          officers and  directors.  The Company and its  officers and  directors
          deny any liability on such claims.

     (b)  On or about May 26, 2000,  WWC  delivered to the Company a shareholder
          proposal  by which WWC  proposed  to  expand  the  Company's  Board of
          Directors to five (5) and proposed a slate of Directors for nomination
          and election at the Company's next annual meeting of shareholders.

     (c)  On June 8, 2000, WWC filed a Schedule  13D/A with the U.S.  Securities
          and Exchange  Commission  in which WWC  expressed an intent to use its
          shareholder  position  to  maximize  shareholder  value,  to help  the
          Company grow, to seek  licensing or sales of Company  technology,  and
          possibly to achieve a sale of the Company at some undetermined  future
          date.

     (d)  WWC is the  owner of  2,370,000  shares of the  Company's  outstanding
          common  stock.  Kilyn  Roth  is the  owner  of  56,250  shares  of the
          Company's  outstanding stock. (e) The Parties now desire to enter into
          this  Agreement  to resolve all possible  disputes  and  controversies
          between them and because  they  believe this  Agreement is in the best
          interests  of  the  Company,   WWC,   Kilyn  Roth  and  the  Company's
          shareholders.


                                      -31-
<PAGE>


     (e)  The  Parties  now desire to enter into this  Agreement  to resolve all
          possible  disputes  and  controversies  between  them and because they
          believe this Agreement is in the best  interests of the Company,  WWC,
          Kilyn Roth and the Company's shareholders.


     (f)  In  consideration of the foregoing  recitals,  which shall be deemed a
          substantive  part  of  this  Agreement,  and in  consideration  of the
          covenants,  promises,   agreements,   representations  and  warranties
          contained in this  Agreement,  and without  admitting any liability or
          wrongdoing, the Parties agree as follows.

2.   Shareholder's Agreement.
     ------------------------
     Contemporaneously  herewith,  the existing directors of the Company and WWC
     have  entered  into a  Shareholders'  Agreement  in the  form  and  content
     attached hereto as Exhibit A and incorporated herein by reference.


3.   Sale of Certain Assets.
     -----------------------
     Contemporaneously  herewith,  the  Company  has  entered  into  a  Purchase
     Agreement  in the  form  and  content  attached  hereto  as  Exhibit  B and
     incorporated  herein  by  reference,  and  WWC  has  executed  a  "Fairness
     Determination" in connection therewith.


4.   Settlement Payment.
     -------------------
     Upon  execution of this  Agreement,  the Company shall pay to Kilyn Roth or
     her  designee  the sum of $20,000  to  facilitate  settlement  of a lawsuit
     brought by Jon Richardson  against WWC, Kilyn Roth and others,  namely Case
     No.  00-CV-760,  Jefferson  County  District  Court.  In exchange  for such
     payment,  WWC and Kilyn Roth agree to indemnify  and hold the Company,  its
     officers,  directors,  employees,  agents and Hurst harmless from any claim
     arising out of Case No. 00-CV-760 or otherwise asserted against the Company
     by Richardson,  provided that WWC's  liability  hereunder  shall not exceed
     $20,000.

                                        2

                                      -32-
<PAGE>


5.   Registration of Stock.
     ----------------------
     Contemporaneously herewith, the Parties have executed a Registration Rights
     Agreement  in the  form  and  content  attached  hereto  as  Exhibit  C and
     incorporated herein by reference.


6.   No Solicitation.
     ----------------
     WWC,  Kilyn Roth and Hurst agree that they shall not directly or indirectly
     contact  any  other  Company   shareholder  for  purposes  of  directly  or
     indirectly  soliciting or encouraging  such shareholder to sue or otherwise
     assert  claims  or  causes  of action  against  the  Company  or any of its
     officers,  directors,  employees,  shareholders,  agents,  and  independent
     contractors  for any of the  Company  released  claims or the WWC  released
     claims.  This  paragraph  shall not be deemed to  prohibit  any party  from
     complying with any subpoena, legal process or other legal requirement.

7.   Release by WWC.
     ---------------
     Except for the obligations created by and set forth in this Agreement or in
     the Exhibits  hereto,  including the exhibits  thereto,  WWC and Kilyn Roth
     (acting for themselves and their agents, shareholders,  employees, members,
     managers,  attorneys,  successors,  assigns,  associates and  consultants),
     including,  but not limited to Kilyn Roth,  J.W. Roth,  Kristine  Brubaker,
     Brett  Brubaker,  and World Wide  Capital  Co.  hereby  forever  completely
     release  and  discharge  the  Company  and  any of its  agents,  attorneys,
     employees,  shareholders,  officers,  directors,  successors,  and assigns,
     including but not limited to Roger D. Hurst,  AspenBio,  Inc., James Musick
     and Erik Van Horn, from any and all claims, causes of action,  obligations,
     liabilities,  demands,  agreements,  injuries, damages, interest, costs and
     expenses (including without limitation, attorney fees), and any other legal
     or equitable remedies of whatever kind or nature, whether known or unknown,
     suspected or unsuspected, contingent or fixed, which arise out of or are in
     any way related to any incident,  act,  failure to act, event, or any other
     matter  occurring  prior to  execution  of this  Agreement  ("WWC  Released
     Claims").

                                        3

                                      -33-
<PAGE>


8.   Rule 144 Transaction.
     ---------------------
     As additional consideration hereunder, the Company agrees to cooperate with
     and  approve  the  removal  of any  restrictive  legend  existing  upon any
     certificate(s)  held by WWC or World Wide  Capital Co. or their  respective
     transferees and representing 142,000 shares of the Company's stock conveyed
     to World  Wide  Capital  Co. by  agreement  dated  November  3, 1998 and to
     further  consent to the further  sale or exchange of such stock;  provided,
     however,  that:(a)  the  transfer  by which WWC or World Wide  Capital  Co.
     requests  removal of such  restrictive  legends shall be in the  reasonable
     opinion  of the  Company's  counsel  in  compliance  with  SEC Rule 144 and
     otherwise  permitted by law; (b) WWC or World Wide Capital Co. shall submit
     to the Company in advance such certificate(s)  together with a true copy of
     the agreement  dated November 3, 1998, and (c) the Company will not contest
     or  challenge  the date  and  validity  of said  agreement.

     As additional consideration hereunder, the Company agrees to cooperate with
     and  approve  the  removal  of any  restrictive  legend  existing  upon any
     certificate(s)  held by Roger  Hurst and to further  consent to the further
     sale or exchange of such stock;  provided,  however,  that the  transfer by
     which Hurst requests  removal of such  restrictive  legends shall be in the
     reasonable opinion of the Company's counsel in compliance with SEC Rule 144
     and otherwise permitted by law.

                                        4

                                      -34-
<PAGE>


9.   Release by Company.
     -------------------
     Except for the obligations created by and set forth in this Agreement or in
     the Exhibits hereto,  including the Exhibits  thereto,  the Company,  Roger
     Hurst,  James  Musick and Erik  VanHorn,  and  AspenBio,  Inc.,  acting for
     themselves and their respective  agents,  attorneys,  employees,  officers,
     directors,  successors,  and assigns, hereby forever completely release and
     discharge  WWC and all of its  affiliates,  agents,  attorneys,  employees,
     including  without  limitation  Kilyn Roth, J.W. Roth,  Kristine  Brubaker,
     Brett  Brubaker  and World Wide  Capital Co. and their  members,  managers,
     successors,  associates,  consultants  and assigns ("World Wide Group") and
     Hurst and  AspenBio,  Inc.,  from any and all  claims,  causes  of  action,
     obligations, liabilities, demands, agreements, injuries, damages, interest,
     costs and expenses (including without  limitation,  attorney fees), and any
     other legal or equitable remedies of whatever kind or nature, whether known
     or unknown, suspected or unsuspected,  contingent or fixed, which arise out
     of or are in any way related to any incident,  act,  failure to act, event,
     or any  other  matter  occurring  prior  to  execution  of  this  Agreement
     ("Company Released Claims").

10.  Voting Rights.
     --------------
     Each of the  parties  hereto  covenants  and agrees not to  contest,  or to
     solicit any other  person to contest,  the right or  authority of any other
     party hereto to vote any shares held by such party in the  Company,  except
     to the extent that such votes are cast in violation of Exhibit A hereto and
     except to the extent that the failure of a party to contest another party's
     voting rights would expose or subject such party to any legal or regulatory
     liability.

                                        5

                                      -35-
<PAGE>

11.  Taxes.
     ------
     WWC shall be solely  responsible  for the payment of taxes, if any are ever
     due, as a result of the payment set forth in paragraph 5 above. The Company
     makes no warranties as to the effect of any tax law or regulation  upon the
     payment set forth in paragraph 5 above.

12.  Costs and Attorney Fees.
     ------------------------
     Each party shall bear his or its own costs and attorney fees and no request
     of any kind  shall  be made to any  court or  person  by any  party to this
     Agreement,  or any agent or  attorney  acting on behalf of any  party,  for
     payment of any costs or attorney fees.

13.  Miscellaneous Provisions.
     -------------------------
     (a)  Conditions  Precedent.  This Agreement is contingent upon the full and
          complete execution,  contemporaneously herewith, of this Agreement and
          all Exhibits hereto, including all exhibits thereto.

     (b)  This  Agreement  shall be binding upon and inure to the benefit of the
          parties   and   their   respective   agents,   attorneys,   employees,
          representatives,  officers,  directors,  members, managers, successors
          and assigns.  However,  no party shall have any right to assign any of
          its rights or obligations  pursuant to this Agreement  except with the
          prior written consent of all other parties.

     (c)  This  Agreement and the exhibits and other  documents  related  hereto
          constitutes the entire agreement among all the parties with respect to
          the   subject   matter   hereof.   No   other   covenants,   promises,
          representations  or  warranties  of any kind have been made  except as
          explicitly set forth herein.

                                        6

                                      -36-
<PAGE>


     (d)  No  provision  of this  Agreement  may be waived,  modified or altered
          except in writing executed by the parties hereto.

     (e)  Each party has  cooperated  in the  drafting and  preparation  of this
          Agreement.  In any  construction  to be  made of  this  Agreement,  no
          presumption   shall   arise   against  any  party  by  virtue  of  its
          participation in the drafting or preparation hereof.

     (f)  This Agreement may be executed in counterparts  or by facsimile,  each
          of which, when all parties have executed at least one such counterpart
          or  facsimile,  shall be deemed an  original,  with the same force and
          effect as if all signatures were appended to one  instrument,  but all
          of which together shall constitute one and the same agreement.

     (g)  This Agreement  shall be construed and governed in accordance with the
          laws of the State of  Colorado  and any action  brought to enforce and
          interpret  this  Agreement  shall be filed in the  District  Court for
          Arapahoe County, Colorado, or the United States District Court for the
          District of Colorado.

     Dated the day and year first above set forth.


VITRO DIAGNOSTICS, INC.                        WORLD WIDE CAPITAL INVESTORS, LLC


By:  /s/ James Musick                    By:  /s/  Kilyn Roth
     --------------------------------         ----------------------------------
Title:   James Musick, Vice President    Title:    Kilyn Roth, Manager
        -----------------------------           --------------------------------


ASPENBIO, INC.                                /s/  Kilyn Roth
                                              ----------------------------------
                                                   Kilyn Roth, Individually

By:   /s/ Roger Hurst
     --------------------------------
Title:    Roger Hurst, President
        -----------------------------


/s/ Roger Hurst
-------------------------------------
    Roger Hurst, Individually



/s/ James R. Musick
-------------------------------------
    James R. Musick, Individually



/s/ Erik VanHorn
-------------------------------------
    Erik VanHorn, Individually

                                        7


                                      -37-
<PAGE>

         Exhibit 10.4 - Registration Rights Agreement dated August 7, 2000
--------------------------------------------------------------------------------


                          Registration Rights Agreement

     This Registration  Rights Agreement  ("Agreement") is entered into this 7th
day of August,  2000,  between  Vitro  Diagnostics,  Inc., a Nevada  corporation
("Company")  and World  Wide  Capital  Investors,  LLC  ("WWC";  WWC may also be
referred to as "Holder").

                                   Recitals:

     Holder is the  record  and  beneficial  owners of common  stock,  $.001 par
value, of the Company owning 2,370,000 shares.

     Holder  wishes to have the right to require the Company to register  all or
part of their  shares  under  the  Securities  Act to  facilitate  resale in the
future.

     Execution  and  delivery of this  Agreement is a condition to a release and
settlement between the parties.

     NOW, THEREFORE, in consideration of the foregoing recitals,  which shall be
considered  an  integral  part of this  Agreement,  and other good and  valuable
consideration,  the receipt and sufficiency of which is hereby acknowledged, the
parties hereby agree as follows:

1.   Definitions. As used herein:

     1.1  The  terms  "register,"  "registered"  and  "registration"  refer to a
          registration effected by preparing and filing a registration statement
          in compliance with the federal Securities Act of 1933, as amended (the
          "Act") and the  declaration or ordering of the  effectiveness  of such
          registration statement.

     1.2  For the purposes hereof the term "Registrable Securities" means shares
          of (i)  common  stock  of  the  Company  owned  by  the  Holders  (the
          "Securities"),  (ii)  stock  issued in lieu of the  Securities  in any
          reorganization  which have not been sold to the public and (iii) stock
          issued in respect of the stock referred in (i) and (ii) as a result of
          a stock split, stock  distribution,  recapitalization  or combination,
          which have not been sold to the public.

     1.3  The terms "Holder" or "Holders"  mean WWC and  qualifying  transferees
          under Section 8 hereof who hold Registrable Securities.

     1.4  The term "Initiating  Holders" means any Holder or Holders of at least
          1,185,001   shares,   cumulatively,   of  Registrable   Securities  or
          Securities  (such number to be adjusted  after the  original  issuance
          thereof for stock splits,  stock  distributions,  recapitalization  or
          combination).

2.   Requested Registration.

     2.1  Request for  Registration.  In case the Company shall receive from the
          Initiating  Holders a written  request  that the  Company  effect  any
          registration  with  respect  to  all  or a  part  of  the  Registrable
          Securities, the Company will on one time only:


                                      -38-
<PAGE>

          (a)  promptly give written notice of the proposed  registration to all
               other Holders; and

          (b)  as soon as  practicable,  use its best  efforts  to  effect  such
               registration (including,  without limitation, the execution of an
               undertaking  to  file  post-effective   amendments,   appropriate
               qualifications  under  the  applicable  blue sky or  other  state
               securities laws limited to 5 states designated by the Holders and
               any other governmental  requirements or regulations) as may be so
               requested  and  as  would  permit  or  facilitate  the  sale  and
               distribution  of all or such portion of such Holder's or Holders'
               Registrable Securities as are specified in such request, together
               with all or such  portion of the  Registrable  Securities  of any
               Holder or Holders  joining in such request as are  specified in a
               written  request  given  within  30 days  after  receipt  of such
               written  notice from the Company  provided that the Company shall
               not be obligated  to take any action to effect such  registration
               pursuant to this Section 2.1:

               (i)  in any particular jurisdiction in which the Company would be
                    required to execute a general  consent to service of process
                    in effecting such registration; or

               (ii) if  the  Company   represents  its  intention  to  effect  a
                    registration  on its own behalf within 90 days of receipt of
                    the written  request  and employs a good faith  effort to do
                    so.

     Subject to the foregoing Subsections (i) and (ii), the Company shall file a
     registration  statement covering the Registrable Securities so requested to
     be registered  as soon as practical,  but in any event within 90 days after
     receipt of the  request or requests of the  Initiating  Holders;  provided,
     however,  that if the Company  shall  furnish to such Holders a certificate
     signed by the  President  of the  Company  stating  that in the good  faith
     judgment of the Board of Directors it would be seriously detrimental to the
     Company and its stockholders for such registration statement to be filed at
     the date filing would be required  and it is  therefore  essential to defer
     the  filing of such  registration  statement,  the  Company  shall  have an
     additional  period of not more than 90 days  after  the  expiration  of the
     initial 90 day period within which to file such registration statement.

     2.2  The Corporation  shall use its best efforts to keep such  registration
          continuously  effective,  and for a period of six months from the date
          on which the SEC declares the  registration  effective or such shorter
          period  which  will  terminate  when  all the  Registrable  Securities
          covered  by  the   registration   have  been  sold  pursuant  to  such
          registration or under Rule 144.

     2.3  The  Initiating  Holders  shall  advise the  Company  in such  written
          request of the  proposed  method of  distribution  and the Holders who
          desire  to  sell  their   Registrable   Securities   pursuant  to  the
          Registration Statement.

     2.4  The Company shall also:

                                       2

                                      -39-

<PAGE>

          (a)  prepare and file with the SEC such amendments and  post-effective
               amendments to the  Registration  Statement as may be necessary to
               keep the  Registration  Statement  effective  for the  applicable
               period;  cause the Prospectus used in connection  therewith to be
               supplemented  by any required  Prospectus  supplement,  and as so
               supplemented   to  be  filed  pursuant  to  Rule  424  under  the
               Securities Act;

          (b)  notify the  selling  Holders of  Registrable  Securities  and the
               managing underwriters, if any, promptly, and (if requested by any
               such  Person)  confirm  such  advice  in  writing,  (1)  when the
               Prospectus  or  any  Prospectus   supplement  or   post-effective
               amendment has been filed,  and, with respect to the  Registration
               Statement  or any  post-effective  amendment,  when  the same has
               become effective, (2) of any request by the SEC for amendments or
               supplements  to the  Registration  Statement or the Prospectus or
               for additional information, (3) of the issuance by the SEC of any
               stop  order  suspending  the  effectiveness  of the  Registration
               Statement or the initiation of any  proceedings for that purpose,
               (4) of the receipt by the  Corporation of any  notification  with
               respect to the suspension of the qualification of the Registrable
               Securities  for sale in any  jurisdiction  or the  initiation  or
               threatening of any proceedings  for such purpose,  and (5) of the
               happening  of any event  which  makes any  statement  made in the
               Registration   Statement,   the  Prospectus,   any  amendment  or
               supplement  thereto,  or any  document  incorporated  therein  by
               reference  untrue or which  requires the making of any changes in
               the  Registration  Statement,  the  Prospectus  or  any  document
               incorporated therein by reference in order to make the statements
               therein not misleading;

          (c)  upon the occurrence of any event contemplated by paragraph (b)(5)
               above,  prepare a supplement or  post-effective  amendment to the
               Registration  Statement or the related Prospectus or any document
               incorporated  therein  by  reference  or file any other  required
               document so that,  as thereafter  delivered to the  purchasers of
               the Registrable  Securities,  the Prospectus will not contain any
               untrue statement of a material fact or omit to state any material
               fact necessary to make the statements therein not misleading; and

          (d)  deliver to each selling holder of Registrable  Securities and the
               underwriters,  if any,  without  charge,  as many  copies  of the
               Prospectus  (including  each  preliminary   Prospectus)  and  any
               amendment or  supplement  thereto as such persons may  reasonably
               request; consent to the use of the Prospectus or any amendment or
               supplement  thereto by each of the selling holders of Registrable
               Securities and the  underwriters,  if any, in connection with the
               offering and sale of the  Registrable  Securities  covered by the
               Prospectus or any amendment or supplement thereto.


                                        3

                                      -40-

<PAGE>

     2.5  Underwriting.  If the  Initiating  Holders  intend to  distribute  the
          Registrable  Securities  covered  by  their  request  by  means  of an
          underwriting,  they  shall so advise  the  Company  as a part of their
          request  made  pursuant to Section 2.1 and the Company  shall  include
          such  information  in the written  notice  referred  to in  Subsection
          2.1(a). In such event, if so requested in writing by the Company,  the
          Initiating Holders shall negotiate with an underwriter selected by the
          Company   with   regard  to  the   underwriting   of  such   requested
          registration; provided, however, that if a majority in interest of the
          Initiating  Holders  have not agreed with such  underwriter  as to the
          terms and  conditions of such  underwriting  within 20 days  following
          commencement  of such  negotiations,  a majority  in  interest  of the
          Initiating  Holders may select an underwriter of their choice with the
          consent  of the  Company,  which  consent  shall  not be  unreasonably
          withheld,  but if consent of the Company  cannot be  obtained,  then a
          majority in interest of the  Initiating  Holders may elect to withdraw
          their  request.  The right of any Holder to  registration  pursuant to
          Section 2.1 shall be conditioned  upon such Holder's  participation in
          such  underwriting  and the  inclusion  of such  Holder's  Registrable
          Securities in the underwriting  (unless otherwise mutually agreed by a
          majority in interest of the Initiating Holders and such Holder) to the
          extent provided  herein.  The Company shall (together with all Holders
          proposing to distribute  their securities  through such  underwriting)
          enter  into an  underwriting  agreement  in  customary  form  with the
          underwriter  or  underwriters  selected  for  such  underwriting  by a
          majority in interest of the Initiating  Holders.  Notwithstanding  any
          other  provision of this Section 2.5, if the  underwriter  advises the
          Initiating  Holders  in  writing  that  marketing  factors  require  a
          limitation of the number of shares to be underwritten,  the Initiating
          Holders shall so advise all holders of Registrable Securities, and the
          number of shares of Registrable Securities that may be included in the
          registration and  underwriting  shall be limited to the number advised
          by the  underwriters  and shall be allocated among all Holders thereof
          in proportion, as nearly as practicable,  to the respective amounts of
          Registrable  Securities  held  by  such  Holders.  If  any  Holder  of
          Registrable  Securities  disapproves of the terms of the underwriting,
          he may elect to withdraw  therefrom by written  notice to the Company,
          the underwriter and the Initiating Holders. Any Registrable Securities
          which  are   excluded   from  the   underwriting   by  reason  of  the
          underwriter's    marketing   limitation   or   withdrawn   from   such
          underwritings shall be withdrawn from such registration.

3.   Company Registration.

     3.1  If at any time or from time to time,  the Company  shall  determine to
          register any of its securities,  for its own account or the account of
          any of its stockholders,  other than a registration on Form S-1 or S-8
          relating  solely  to  employee  stock  option or  purchase  plans or a
          registration   on  Form  S-4  relating  solely  to  an  SEC  Rule  145
          transaction, the Company will:

          (a)  promptly  give to each  Holder a written  notice  thereof  (which
               shall  include a list of the  jurisdictions  in which the Company
               intends  to  attempt  to  qualify  such   securities   under  the
               applicable blue sky or other state securities laws); and

          (b)  include in such registration (and any related qualification under
               blue  sky  laws or  other  compliance),  and in any  underwriting
               involved therein,  all the Registrable  Securities specified in a
               written request or requests, made within 30 days after receipt of
               such written  notice from the Company,  by any holder or holders,
               except as set forth in Section 3.2 below.


                                        4

                                      -41-
<PAGE>

     3.2  Underwriting. If the registration of which the Company gives notice is
          for a  registered  public  offering  involving  an  underwriting,  the
          Company  shall so advise  the  Holders as part of the  written  notice
          given  pursuant  to  Section  3.1(a).  In such  event the right of any
          Holder to  registration  pursuant to Section 3.1 shall be  conditioned
          upon  such  Holder's   participation  in  such  underwriting  and  the
          inclusion of such Holder's Registrable  Securities in the underwriting
          to the extent  provided  herein.  All Holders  proposing to distribute
          their  securities   through  such  underwriting  must  enter  into  an
          underwriting  agreement  in  customary  form with the  underwriter  or
          underwriters   selected   for  such   underwriting   by  the  Company.
          Notwithstanding  any  other  provision  of this  Section  3.1,  if the
          underwriter  determines that marketing factors require a limitation of
          the number of shares to be underwritten, the underwriter may limit the
          amount  of  securities  to  be  included  in  the   registration   and
          underwriting  by the  Company's  stockholders.  The  Company  shall so
          advise all Holders of Registrable  Securities which would otherwise be
          registered and underwritten  pursuant hereto, and the number of shares
          of Registrable Securities that may be included in the registration and
          underwriting   shall  be   allocated   among  all  of  the   Company's
          stockholders   (including  Holders)  who  are  not  exercising  demand
          registration  rights,  in proportion,  as nearly as practicable to the
          respective  amounts of  securities  requested  to be  included in such
          registration  held by such  stockholder  at the  time  of  filing  the
          registration  statement. If any Holder disapproves of the terms of any
          such  underwriting,  he may elect to  withdraw  therefrom  by  written
          notice to the Company and the underwriter.  Any Registrable Securities
          excluded or withdrawn from such  underwriting  shall be withdrawn from
          such registration.

4.   Registration On Form S-3.

     4.1  Form S-3.  The  Company  shall use its best  efforts  to  qualify  for
          registration on Form S-3 or its successor form.  After the Company has
          qualified for the use of Form S-3,  Holders of Registrable  Securities
          shall have the right to request up to three  registrations on Form S-3
          (such  requests  shall be in  writing  and shall  state the  number of
          shares of  Registrable  Securities  to be disposed of and the intended
          method of disposition of shares by such Holders),  subject only to the
          following:

          (a)  The  Company  shall  not be  required  to  effect a  registration
               pursuant to this Section 4.1 within 90 days of the effective date
               of any registration referred to in Sections 2.1 and 3.1 above.

          (b)  The  Company  shall  not be  required  to  effect a  registration
               pursuant  to this  Section  4.1  unless  the  Holder  or  Holders
               requesting   registration   propose   to  dispose  of  shares  of
               Registrable  Securities  having an  aggregate  disposition  price
               (before deduction of underwriting discounts and expenses of sale)
               of at least Five Hundred Thousand Dollars ($500,000).

          (c)  The  Company  shall  not be  required  to  effect a  registration
               pursuant to this Section 4.1 within 90 days of the effective date
               of the last such registration pursuant to this Section 4.1.

          The Company  shall give written  notice to all Holders of  Registrable
     Securities  of the receipt of a request for  registration  pursuant to this
     Section 1.4 and shall provide a reasonable opportunity for other Holders to
     participate in the  registration,  provided that if the registration is for
     an  underwritten  offering,  the terms of Section 3.2(b) shall apply to all
     participants in such offering.  Subject to the foregoing,  the Company will
     use its best efforts to effect  promptly the  registration of all shares of
     Registrable Securities on Form S-3 to the extent requested by the Holder or
     Holders thereof for purposes of disposition.

5.   Expenses of  Registration.  All expenses  incurred in  connection  with any
     registration pursuant to this Agreement, including, without limitation, all
     registration,  filing and qualification fees,  printing expenses,  fees and
     disbursements of counsel for the Company and expenses of any special audits
     of the  Company's  financial  statements  incidental to or required by such
     registration, shall be borne by the Company except as follows:

                                       5

                                      -42-
<PAGE>


     5.1  If the  Company is not  registering  any  shares  for its own  account
          pursuant to any  registration  effected  under  Section 2.1,  then the
          selling  Holders shall bear all expenses  incurred in connection  with
          any special audits of the Company's financial statements incidental to
          or required by such registration.

     5.2  The  Company  shall  not  be  required  to  pay  for  expenses  of any
          registration proceeding begun pursuant to Section 2.1, the request for
          which has been subsequently  withdrawn by the Initiating  Holders,  in
          which  latter  case,  such  expenses  shall be  borne  by the  Holders
          requesting such withdrawal.

     5.3  The Company  shall not be  required to pay fees of legal  counsel of a
          Holder  except  for a single  counsel  whose fees shall not exceed Two
          Thousand  Five  Hundred  Dollars  ($2,500.00)  acting on behalf of all
          selling  Holders,  or  underwriters  fees,  discounts  or  commissions
          relating to Registrable Securities.

6.   Indemnification.

     6.1  To the extent permitted by law, the Company will indemnify each Holder
          of Registrable Securities, each of its officers,  directors,  partners
          and members,  and each person controlling such Holder, with respect to
          which such  registration has been effected pursuant to this Section 1,
          and  each  underwriter,  if any,  and each  person  who  controls  any
          underwriter of the Registrable  Securities held by or issuable to such
          Holder, against all claims, losses, expenses,  damages and liabilities
          (or actions in respect  thereto) arising out of or based on any untrue
          statement (or alleged  untrue  statement) of a material fact contained
          in any prospectus,  offering circular or other document (including any
          related registration statement,  notification or the like) incident to
          any such registration,  or based on any omission (or alleged omission)
          to state  therein a material  fact  required  to be stated  therein or
          necessary  to make  the  statements  therein  not  misleading,  or any
          violation by the Company of any rule or regulation  promulgated  under
          the  Securities  Act or any state  securities  law  applicable  to the
          Company in connection with any such  registration,  and will reimburse
          each such Holder,  each of its officers,  directors and partners,  and
          each person  controlling  such Holder,  each such underwriter and each
          person who controls any such underwriter, for any reasonable legal and
          any  other  expenses   incurred  in  connection  with   investigating,
          defending  or settling  any such claim,  loss,  damage,  liability  or
          action,  provided that the  indemnity  contained in this Section shall
          not apply to  amounts  paid in  settlement  of any such  claim,  loss,
          damage, liability or action if such settlement is effected without the
          consent  of the  Company  (which  consent  will  not  be  unreasonably
          withheld) and provided  further that the Company will not be liable in
          any such  case to the  extent  that any such  claim,  loss,  damage or
          liability  arises  out of or is  based  on  any  untrue  statement  or
          omission  based upon written  information  furnished to the Company by
          such Holder or underwriter specifically for use therein.


                                       6

                                      -43-
<PAGE>


     6.2  Each Holder will,  if  Registrable  Securities  held by or issuable to
          such  Holder  are  included  in  the   securities  as  to  which  such
          registration  is being  effected,  indemnify the Company,  each of its
          directors and officers,  each legal counsel and independent accountant
          of the Company, each underwriter,  if any, of the Company's securities
          covered by such a registration statement, each person who controls the
          Company within the meaning of the Securities  Act, and each other such
          Holder,  each of its officers,  directors and partners and each person
          controlling such Holder, against all claims, losses, expenses, damages
          and  liabilities  (or  actions in respect  thereof)  arising out of or
          based on any untrue  statement  (or  alleged  untrue  statement)  of a
          material   fact   contained  in  any  such   registration   statement,
          prospectus,  offering circular or other document,  or any omission (or
          alleged  omission)  to state  therein a material  fact  required to be
          stated  therein  or  necessary  to make  the  statements  therein  not
          misleading,  and  will  reimburse  the  Company,  such  Holders,  such
          directors,   officers,  partners,  persons  or  underwriters  for  any
          reasonable investigating, defending, or settling any such claim, loss,
          damage,  liability or action, in each case to the extent,  but only to
          the extent,  that such untrue statement (or alleged untrue  statement)
          or  omission  (or  alleged  omission)  is made  in  such  registration
          statement, prospectus, offering circular or other document in reliance
          upon and in  conformity  with  written  information  furnished  to the
          Company by such Holder  specifically  for use  therein;  and  provided
          further that the indemnity  contained in the paragraph shall not apply
          to  amounts  paid in  settlement  of any  such  claim,  loss,  damage,
          liability or action if such settlement is effected without the consent
          of the Holder (which consent will not be unreasonably withheld).

     6.3  Each party  entitled  to  indemnification  under  this  Section 6 (the
          "Indemnified  Party")  shall  give  notice  to the party  required  to
          provide indemnification (the "Indemnifying Party") promptly after such
          Indemnified  Party  has  actual  knowledge  of any  claim  as to which
          indemnity may be sought,  and shall permit the  Indemnifying  Party to
          assume  the  defense  of any such  claim or any  litigation  resulting
          therefrom, provided that counsel for the Indemnifying Party, who shall
          conduct the defense of such claim or litigation,  shall be approved by
          the  Indemnified  Party  (whose  approval  shall  not be  unreasonably
          withheld),  and the Indemnified  Party may participate in such defense
          at such party's expense,  and provided further that the failure of any
          Indemnified  Party to give notice as provided herein shall not relieve
          the  Indemnifying  Party of its  obligations  hereunder,  unless  such
          failure  resulted in actual  detriment to the  Indemnifying  Party. No
          Indemnifying  Party,  in the defense of any such claim or  litigation,
          shall,  except with the consent of each Indemnified Party,  consent to
          entry of any  judgment  or enter  into any  settlement  which does not
          include as an unconditional term thereof the giving by the claimant or
          plaintiff to such Indemnified Party of a release from all liability in
          respect to such claim or litigation.

7.   Rule  144  Reporting.  With  a view  to  making  available  to  Holders  of
     Registrable Securities the benefits of certain rules and regulations of the
     SEC which may permit the sale of the  Registrable  Securities to the public
     without registration, the Company agrees at all time to:

     7.1  make  and keep  public  information  available,  as  those  terms  are
          understood and defined in SEC Rule 144;

     7.2  use its best  efforts  to file  with the SEC in a  timely  manner  all
          reports  and  other  documents  required  of  the  Company  under  the
          Securities Act and the Securities Exchange Act;

                                        7

                                      -44-
<PAGE>

     7.3  so long as a Holder  owns any  Registrable  Securities,  to furnish to
          each  such  holder  forthwith  upon  such  Holder's  request a written
          statement  by the  Company  as to its  compliance  with the  reporting
          requirements  of said  Rule 144 (at any time  after 90 days  after the
          effective  date  of the  first  registration  statement  filed  by the
          Company for an offering of its securities to the general public),  and
          of the  Securities  Act and the  Securities  Exchange Act (at any time
          after it has become subject to such reporting requirements), a copy of
          the most recent  annual or quarterly  report of the Company,  and such
          other  reports  and  documents  so filed by the  Company  as each such
          Holder  may  reasonably  request  in  availing  itself  of any rule or
          regulation of the SEC allowing such Holder to sell any such securities
          without registration.

8.   Transfer  of  Registration  Rights.  The  rights  to cause the  Company  to
     register Registrable Securities of a Holder and keep information available,
     granted to a Holder by the Company  under  Sections 2.1, 3.1, 4.1 and 7 may
     be assigned  by a Holder to a  transferee  or assignee of at least  100,000
     shares of the  Registrable  Securities  provided  that the Company is given
     written  notice  by the  Holder,  stating  the  name  and  address  of said
     transferee or assignee and identifying the securities with respect to which
     such registration rights are being assigned.

9.   Rights Granted to Subsequent Investors.  Within the limitations  prescribed
     by this  Section,  but not  otherwise,  the Company may grant to subsequent
     investors in the Company rights of incidental registration. Such rights may
     only pertain to shares of Common  Stock,  including  shares of Common Stock
     into which any other  securities  of the  Company  may be  converted.  Such
     rights  may be  granted  with  respect to  registrations  initiated  by the
     Company,  but only in respect to that  portion of such  registration  as is
     available to the Holders of Registrable  Securities  (together with holders
     of securities  heretofore  granted  rights to  participate in the available
     portion of such registration)  under the limitations set forth herein. Such
     rights  shall be limited in all cases to sharing pro rata in the  available
     portion  of  the  registration  in  question  with  all  other  holders  of
     securities  having  rights to  participate  therein  (including  Holders of
     Registrable  Securities),  such sharing to be based on the number of shares
     of Common Stock held by the respective  Holders,  plus the number of shares
     of Common  Stock into  which  other  securities  held by such  Holders  are
     convertible, which are entitled to registration rights.

          The  Company  may not grant to  subsequent  investors  in the  Company
     rights of  registration  upon request unless (i) such rights are limited to
     shares of Common Stock, and (ii) all Holders of Registrable  Securities are
     given  enforceable  contractual  rights  to  participate  in  registrations
     requested by such subsequent  investors,  such participation to be on a pro
     rata basis with all Holders of Securities entitled to such rights.

10.  No-Action   Letter  or  Opinion   of  Counsel  in  Lieu  of   Registration.
     Notwithstanding  anything else in this Agreement, if the Company shall have
     obtained from the SEC a  "no-action"  letter in which the SEC has indicated
     that it will take no action if, without  registration  under the Securities
     Act, any Holder disposes of Registrable  Securities  covered by any request
     for registration  made under Section 2.1, 3.1 or 4.1 in the manner in which
     such Holder proposes to dispose of the Registrable  Securities  included in
     such  request or if in the opinion of counsel for the Company  concurred in
     by counsel for such Holder,  no  registration  under the  Securities Act is
     required in connection with such  disposition,  the Registrable  Securities
     included in such request shall not be eligible for registration  under this
     Agreement.

11.  "Market Standoff" Agreement. Each of WWC and Hansen agrees, if requested by
     the Company and an underwriter of Common Stock (or other securities) of the
     Company,  not to sell or otherwise  transfer or dispose of any Common Stock
     (or other  securities)  of the  Company  held by WWC and Hansen  during the
     120-day period following the effective date of a registration  statement of
     the Company filed under the Act, provided that:



                                        8

                                      -45-
<PAGE>

     11.1 such agreement shall only apply to the first registration statement of
          the Company  including shares (or securities) to be sold on its behalf
          to the public in an  underwritten  offering  and filed  after the date
          hereof; and

     11.2 all  officers  and   directors  of  the  Company  enter  into  similar
          agreements.

          Such  agreement  shall be in writing in the form  satisfactory  to the
     Company  and  such  underwriter.  The  Company  may  impose  stop  transfer
     instructions  with  respect to the shares  (or  securities)  subject to the
     foregoing restriction until the end of said 120-day period.

12.  Termination  of  Registration   Rights.  The  registration  rights  granted
     pursuant to this Agreement  shall  terminate as to each Holder at such time
     as all Registrable  Securities of the Holder can, in the opinion of counsel
     to the  Company  (which  opinion  shall be  concurred  in by counsel to the
     Holders) be sold within a given three-month  period pursuant to Rule 144 or
     other applicable exemption.

13.  Delay of Registration. No Holder shall have any right to take any action to
     restrain,  enjoin or otherwise delay any  registration as the result of any
     controversy  that  may  arise  with  respect  to  the   interpretation   or
     implementation of this Agreement.

     IN  WITNESS  WHEREOF,  the  parties  have  executed  this  Agreement  to be
effective on the day and year first written above.


                                  THE COMPANY:
                                  Vitro Diagnostics, Inc.


                                  By: /s/ James R. Musick
                                      ---------------------------------------
                                          James R. Musick, Vice President


                                  WORLD WIDE CAPITAL, LLC


                                  By:   /s/ Kilyn Roth
                                       --------------------------------------
                                  Its:      Kilyn Roth, Manager
                                       --------------------------------------


                                        9

                                      -46-



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