CISTRON BIOTECHNOLOGY INC
SC 13G, 1998-11-17
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13G


                    Under the Securities Exchange Act of 1934
                                (Amendment No. )*

                           CISTRON BIOTECHNOLOGY, INC.
                         -------------------------------
                                (Name of Issuer)


                          Common Stock, $0.01 Par Value
                        ----------------------------------
                         (Title of Class of Securities)

                                    172849101
                              --------------------
                                 (CUSIP Number)

                                October 30, 1998
                     ---------------------------------------
                      (Date of Event which Requires Filing
                               of this Statement)

Check the  appropriate box to designate the rule pursuant to which this Schedule
is filed:

                  [ ]     Rule 13d-1(b)
                  [X]      Rule 13d-1(c)
                  [ ]     Rule 13d-1(d)


*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter disclosure
provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).





                         Continued on following page(s)
                               Page 1 of 10 Pages
                              Exhibit Index: Page 8


<PAGE>


                                  SCHEDULE 13G

CUSIP No. 172849101                                           Page 2 of 10 Pages




1        Name of Reporting Person
         I.R.S. Identification No. of Above Persons (ENTITIES ONLY)

                  Rhone-Poulenc S.A.

2        Check the Appropriate Box If a Member of a Group*
                                                     a.  [ ]
                                                     b.  [x]
3        SEC Use Only

4        Citizenship or Place of Organization

                  FRANCE

                           5        Sole Voting Power
 Number of                                  0
   Shares
Beneficially               6       Shared Voting Power
  Owned By                                  2,000,000
    Each
  Reporting                7       Sole Dispositive Power
   Person                                   0
    With
                           8        Shared Dispositive Power
                                            2,000,000

9        Aggregate Amount Beneficially Owned by Each Reporting Person

                                            2,000,000

10       Check Box If the Aggregate Amount in Row (9) Excludes Certain
         Shares*
                                        [  ]

11       Percent of Class Represented By Amount in Row (9)

                                    8.00%

12       Type of Reporting Person*

                  CO

                     * SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>


                                  SCHEDULE 13G

CUSIP No. 172849101                                           Page 3 of 10 Pages



1        Name of Reporting Person
         I.R.S. Identification No. of Above Persons (ENTITIES ONLY)

                  Pasteur Merieux Serums & Vaccins, S.A.

2        Check the Appropriate Box If a Member of a Group*
                                                     a.  [ ]
                                                     b.  [x]
3        SEC Use Only

4        Citizenship or Place of Organization

                  FRANCE

                           5        Sole Voting Power
 Number of                                  0
   Shares
Beneficially               6       Shared Voting Power
  Owned By                                  2,000,000
    Each
  Reporting                7       Sole Dispositive Power
   Person                                   0
   With
                           8        Shared Dispositive Power
                                            2,000,000

9        Aggregate Amount Beneficially Owned by Each Reporting Person

                                            2,000,000

10       Check Box If the Aggregate Amount in Row (9) Excludes Certain Shares*

                                             [ ]

11       Percent of Class Represented By Amount in Row (9)

                                    8.00%

12       Type of Reporting Person*

                  OO

                     * SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>


                          

                                                              Page 4 of 10 Pages


Item 1(a)         Name of Issuer:

                  Cistron Biotechnology, Inc. ("Issuer").

Item 1(b)         Address of the Issuer's Principal Executive Offices:

                  101 Bloomfield Avenue, Pine Brook, New Jersey 07058.

Item 2(a)         Name of Person Filing:

                  This  statement  is filed on behalf  of each of the  following
                  persons (collectively, the "Reporting Persons"):

                  i)       Rhone-Poulenc S.A. ("Rhone-Poulenc"); and

                  ii)      Pasteur Merieux Serums & Vaccins, S.A. ("PMSV").

                  This Statement  relates to Shares (as defined herein) held for
the account of PMSV. PMSV is a wholly-owned subsidiary of Rhone-Poulenc.

Item 2(b)         Address of Principal Business Office or, if None, Residence:

                  The address of the principal  business office of Rhone-Poulenc
is 25 Quai Paul  Doumer,  92408  Courbevoie  Cedex,  France.  The address of the
principal business office of PMSV is 58 Avenue Leclerc, 69007 Lyon, France.

Item 2(c)         Citizenship:

                  i)       Rhone-Poulenc is a French societe anonyme; and

                  ii)      PMSV is a French societe anonyme.


Item 2(d)         Title of Class of Securities:

                           Common Stock, $0.01 par value (the "Shares").

Item 2(e)         CUSIP Number:

                           172849101



<PAGE>


                             

                                                              Page 5 of 10 Pages



Item 3.       If this statement is filed pursuant to Rule 13d-1(b), or 13d-2(b),
              check whether the person filing is a:

                           This Item 3 is not applicable.

Item 4.       Ownership:

Item 4(a)     Amount Beneficially Owned:

                           As of  November  13,  1998,  each  of  the  Reporting
                           Persons  may be deemed  the  beneficial  owner of the
                           following number of Shares:

                           i)       Each of Rhone-Poulenc and PMSV may be deemed
                                    to be  the  beneficial  owner  of  2,000,000
                                    Shares  held for the  account of PMSV.  This
                                    number consists of (A) 1,333,333 Shares held
                                    for  the  account  of PMSV  and (B)  666,667
                                    Shares issuable upon the exercise of 666,667
                                    currently  exercisable warrants held for the
                                    account of PMSV.

                           All of the Shares and  warrants  held for the account
                           of PMSV were purchased in a private transaction.

Item 4(b)     Percent of Class:

                           i)       The  number  of  Shares  of  which  each  of
                                    Rhone-Poulenc  and PMSV may be  deemed to be
                                    the     beneficial     owner     constitutes
                                    approximately  8.00% of the total  number of
                                    Shares outstanding (assuming exercise of the
                                    666,667  warrants  held for the  account  of
                                    PMSV).


Item 4(c)     Number of shares as to which such person has:

     Rhone-Poulenc
     -------------

     (i)      Sole power to vote or to direct the vote:                        0

     (ii)     Shared power to vote or to direct the vote:              2,000,000

     (iii)    Sole power to dispose or to direct the disposition of:           0

     (iv)     Shared power to dispose or to direct the disposition of: 2,000,000



<PAGE>


                                

                                                              Page 6 of 10 Pages


     PMSV
     ----

     (i)    Sole power to vote or to direct the vote:                          0

     (ii)   Shared power to vote or to direct the vote:                2,000,000

     (iii)  Sole power to dispose or to direct the disposition of:             0

     (iv)   Shared power to dispose or to direct the disposition of    2,000,000

Item 5.     Ownership of Five Percent or Less of a Class:

                  This Item 5 is not applicable.

Item 6.     Ownership of More than Five Percent on Behalf of Another Person:

            (i)   The   shareholders   of   Rhone-Poulenc   have  the  right  to
participate in the receipt of dividends  from, or proceeds from the sale of, the
Shares, held by PMSV in accordance with their ownership interests in PMSV.

            (ii)  The  shareholders of PMSV have the right to participate in the
receipt of dividends  from, or proceeds  from the sale of, the Shares,  held for
PMSV's account.

Item 7.     Identification  and  Classification of the Subsidiary Which Acquired
            the Security Being Reported on by the Parent Holding Company:

                  This Item 7 is not applicable.

Item 8.     Identification and Classification of Members of the Group:

                  This Item 8 is not applicable.

Item 9.     Notice of Dissolution of Group:

                  This Item 9 is not applicable.

Item 10.    Certification:

                  By signing below each signatory certifies that, to the best of
his/its knowledge and belief, the securities referred to above were not acquired
and  are  not  held  for the  purpose  of or with  the  effect  of  changing  or
influencing  the control of the Issuer of the  securities  and were not acquired
and are not  held in  connection  with or as a  participant  in any  transaction
having that purpose or effect.



<PAGE>


                               

                                                              Page 7 of 10 Pages


                                   SIGNATURES


After  reasonable  inquiry  and to the  best of my  knowledge  and  belief,  the
undersigned  certifies that the information set forth in this statement is true,
complete and correct.

Date:  November 13, 1998               RHONE-POULENC S.A.


                                       By:   /s/ Damian Braga
                                             -----------------------------------
                                             Damian Braga
                                             Attorney-in-Fact


Date:  November 13, 1998               PASTEUR MERIEUX SERUMS & VACCINS, S.A.


                                       By:   /s/ Damian Braga
                                             -----------------------------------
                                             Damian Braga
                                             Attorney-in-Fact




<PAGE>


                               

                                                              Page 8 of 10 Pages




                                  EXHIBIT INDEX

                                                                        Page No.
                                                                        --------
A.        Page No. Power of Attorney dated as of November 9,
          1998 granted by Pasteur  Merieux Serums & Vaccins,
          S.A. and  Rhone-Poulenc  S.A. in favor of David J.
          Williams, Damian Braga, Paul Kirkconnell,  Doug B.
          Reynolds and Robert Becker........................                   9
          
B         Joint Filing  Agreement dated November 13, 1998 by
          and among  Rhone-Poulenc  S.A. and Pasteur Merieux
          Serums & Vaccins,S.A..............................                  10








                              

                                                              Page 9 of 10 Pages



                                    EXHIBIT A

                                POWER OF ATTORNEY


KNOW ALL MEN BY THESE PRESENT,  that the  undersigned  Pasteur  Merieux Serums &
Vaccins,  S.A., and  Rhone-Poulenc  S.A., each a societe  anonyme  organized and
existing  under  the  laws  of  the  French  Republic  (the  "Company"),  hereby
designate,  constitute  and  appoint  DAVID  J.  WILLIAMS,  DAMIAN  BRAGA,  PAUL
KIRKCONNELL,  DOUG B. REYNOLDS AND ROBERT BECKER, acting individually,  as their
true and lawful agent and attorney-in-fact,  to execute and deliver, in the name
and on behalf of the  undersigned,  all  documents,  certificates,  instruments,
statements,  filings and agreements  ("documents") to be filed with or delivered
to any  foreign or  domestic  governmental  or  regulatory  body or  required or
requested  by any other  person or entity  pursuant  to any legal or  regulatory
requirement relating to the acquisition, ownership, management or disposition of
securities or other  investments,  and any other documents relating or ancillary
thereto,  including but not limited to, all  documents  relating to filings with
the United States Securities and Exchange Commission (the "SEC") pursuant to the
Securities  Act of 1933 or the  Securities  Exchange Act of 1934 (the "Act") and
the rules and regulations promulgated thereunder,  including:  (1) all documents
relating to the beneficial ownership of securities required to be filed with the
SEC pursuant to Section  13(d) or Section  16(a) of the Act  including,  without
limitation:  (a) any acquisition  statements on Schedule 13D or Schedule 13G and
any  amendments  thereto,  (b) any  joint  filing  agreements  pursuant  to Rule
13d-1(f)  and (c) any  initial  statements  of, or  statements  of  changes  in,
beneficial  ownership  of  securities  on Form  3,  Form 4 or Form 5 and (2) any
information statements on Form 13F required to be filed with the SEC pursuant to
Section 13(f) of the Act.

All past acts of the attorney-in-fact in furtherance of the foregoing are hereby
ratified and confirmed.

IN  WITNESS  WHEREOF,  I have  executed  this  instrument  as of the  9th day of
November, 1998.

                                  PASTEUR MERIEUX SERUMS & VACCINS, S.A.


                                  By:   /s/ Herve Tainturier
                                        ----------------------------------------
                                        Senior Vice President, Legal & Corporate
                                        Affairs

                                  RHONE-POULENC S.A.

                                  By:   /s/ Herve Tainturier
                                        ----------------------------------------






                                 

                                                             Page 10 of 10 Pages

                                    EXHIBIT B

                             JOINT FILING AGREEMENT

         The  undersigned  hereby agree that the  statement on Schedule 13G with
respect to the Common Stock of Cistron Biotechnology,  Inc. dated as of November
13, 1998 is, and any amendments thereto  (including  amendments on Schedule 13D)
signed by each of the  undersigned  shall be,  filed on behalf of us pursuant to
and in accordance  with the  provisions of Rule  13d-1(f)  under the  Securities
Exchange Act of 1934.


Date:  November 13, 1998               RHONE-POULENC S.A.


                                       By:   /s/ Damian Braga
                                             -----------------------------------
                                             Damian Braga
                                             Attorney-in-Fact


Date:  November 13, 1998               PASTEUR MERIEUX SERUMS & VACCINS, S.A.


                                       By:   /s/ Damian Braga
                                             -----------------------------------
                                             Damian Braga
                                             Attorney-in-Fact






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