CISTRON BIOTECHNOLOGY INC
SC 13D, 1999-08-04
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D

                    Under the Securities Exchange Act of 1934
                          (Amendment No.____________)*


                           Cistron Biotechnology, Inc.
- --------------------------------------------------------------------------------
                                (Name of Issuer)


                                  Common Stock
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)


                                   172849 10 1
- --------------------------------------------------------------------------------
                                 (CUSIP Number)


                               Harvey Wm. Glasser
                         2000 Powell Street, Suite 1650
                          Emeryville, California 94608
                                  (510)601-1044
- --------------------------------------------------------------------------------
                  (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)


                                 April 20, 1999
- --------------------------------------------------------------------------------
                      (Date of Event which Requires Filing
                               of this Statement)


If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule  because  of  240.13d-1(e),  240.13d-1(f)  or  240.13d-1(g),  check the
following box [ ].

Note:  Schedules  filed in paper format shall include a signed original and five
copies of the  schedule,  including  all  exhibits.  See Rule 13d-7(b) for other
parties to whom copies are to be sent.

<PAGE>

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for any  subsequent  amendment  containing  information  which  would  alter the
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).



<PAGE>



CUSIP No.         172849 10 1                                 13D



- --------------------------------------------------------------------------------
   1   NAMES OF REPORTING PERSONS
       I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

       Harvey Wm. Glasser
- --------------------------------------------------------------------------------
   2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
                                                             (a)  [  ]
                                                             (b)  [  ]
- --------------------------------------------------------------------------------
   3   SEC USE ONLY

- --------------------------------------------------------------------------------
   4   SOURCE OF FUNDS (SEE INSTRUCTIONS)

       Other - OO
- --------------------------------------------------------------------------------
   5   CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
       ITEMS 2(d) OR 2(e)                                         [  ]

- --------------------------------------------------------------------------------
   6   CITIZENSHIP OR PLACE OF ORGANIZATION

       USA
- --------------------------------------------------------------------------------
   NUMBER OF      7    SOLE VOTING POWER
     SHARES            186,500
  BENEFICIALLY    --------------------------------------------------------------
    OWNED BY      8    SHARED VOTING POWER
      EACH                0
   REPORTING      --------------------------------------------------------------
     PERSON       9    SOLE DISPOSITIVE POWER
      WITH             186,500
                  --------------------------------------------------------------
                  10   SHARED DISPOSITIVE POWER
                          0
- --------------------------------------------------------------------------------
  11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

       186,500
- --------------------------------------------------------------------------------
12   CHECK BOX IF THE AGGREGATE  AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES
     (SEE INSTRUCTIONS)

                                                                      [  ]
- --------------------------------------------------------------------------------
  13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

       1
- --------------------------------------------------------------------------------
  14   TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

       IN
- --------------------------------------------------------------------------------

<PAGE>

                                  Schedule 13D


Item 1.  Security and Issuer

         This  statement  relates to the Common Stock of Cistron  Biotechnology,
Inc.  ("Cistron").  Cistron's  executive  offices are  located at 10  Bloomfield
Avenue, Pine Brook, New Jersey, 07058.


Item 2.  Identity and Background

         (a)   Harvey Wm. Glasser.

         (b)   2000 Powell Street, Suite 1650, Emeryville, California.

         (c)   Chairman  of the Board,  President  and Chief  Executive  Officer
               Western Property Holdings.

         (d)   The Reporting  Person has not,  during the last five years,  been
               convicted in a criminal proceeding  (excluding traffic violations
               or similar misdemeanors).

         (e)   During the last five years,  the Reporting Person was not a party
               to a civil  proceeding  of  judicial  or  administrative  body of
               competent jurisdiction resulting in the Reporting Person becoming
               subject to a  judgment,  decree or final order  enjoining  future
               violations of, or prohibiting or mandating activities subject to,
               federal or state  securities  laws or finding any violation  with
               respect to such laws.

         (f)   United States of America.

Item 3.  Source and Amount of Funds or Other Consideration

         The  Reporting  Person owns 186,500  shares of Common  stock,  which he
acquired in 1995.  The total  purchase  price of these shares was $20,052.02 and
was paid with personal funds of the Reporting Person.

         As described  below,  the Reporting  Person has  beneficially  owned an
additional  5,058,406 shares (the "Additional  Shares"),  which he acquired from
the bankruptcy estate (the "Estate") of Dr. Henry Grausz ("Grausz").  Grausz had
used the Additional  Shares (as well as another  500,000 shares of Common Stock)
as collateral for loans from Imperial Bank  ("Imperial") for which the Reporting
Person had also provided additional security.  Imperial subsequently transferred
the secured loans to Imperial Loan  Management  Corporation  ("ILMC").  Imperial
financed  ILMC's  purchase of the loans and obtained a security  interest in the
Additional Shares (and in the additional 500,000 shares and security provided by
the Reporting  Person).  ILMC entered into an agreement  with Grausz dated as of
April  20,  1999  (the  "Bankruptcy  Agreement"),  which  the  bankruptcy  court
administering  Grausz's  bankruptcy  case  approved  by final  order (the "Court
Order"), under which Grausz agreed to transfer the Additional Shares to ILMC, or
its designee,  in satisfaction of a portion of the debt owing by Grausz to ILMC.
ILMC designated the Reporting Person the buyer pursuant to the agreement between
ILMC and the Reporting Person described below.

         On June 21, 1999,  the Reporting  Person entered into an agreement (the
"Sale  Agreement")  to sell the  Additional  Shares to Cistron in  exchange  for
$1,150,000 or a per share price of $0.2274 in a private  transaction  (the "Sale
Transaction").  In accordance with the terms of agreements between the Reporting
Person and Imperial and ILMC,  most of the proceeds were used to pay down ILMC's
debt to Imperial and other  obligations of ILMC.  Some of the proceeds were paid
to the Estate in  accordance  with the terms of the Court  Order and  Bankruptcy
Agreement. The closing of the Sale Transaction occurred on July 8, 1999.

<PAGE>

Item 4.  Purpose of Transaction

         As noted in response to Item 3 above, the Reporting Person acquired the
Additional  Shares from the Estate in satisfaction of a portion of Grausz's debt
to ILMC.  Pursuant to the Bankruptcy  Agreement and the Court Order (and a prior
order of the bankruptcy  court),  the Reporting Person agreed to try to sell the
Additional  Shares to make the  payment  to the  Estate  and the other  payments
described in the response to Item 3 above.  The Reporting Person did not acquire
the  Additional  Shares for the purpose of joining and has no intent to join the
Board of Cistron or exercise  controlling  voting power or otherwise  pursue any
plan or proposal of the type identified in Item 4.

Item 5.  Interest in Securities of the Issuer

         The Reporting Person has sole voting power and sole  dispositive  power
with respect to 186,500 shares of Common Stock, representing approximately 1% of
the  outstanding  share of Common Stock (as taken from Cistron's most recent 10K
filing).  The Reporting  Person ceased to be the  beneficial  owner of more than
five percent of the Common Stock on Cistron on July 8, 1999 pursuant tot he Sale
Transaction described in the response to Item 3 above.

Item 6.  Contracts, Arrangements, Understandings or Relationships with Respect
to Securities of the Issuer.

         See Response to Item 3 above. Copies of the Court Order, the Bankruptcy
Agreement, and the Sale Agreement are attached as Exhibits hereto.

Item 7.  Material to be Filed as Exhibits

         Exhibit 99.1 - Court Order
         Exhibit 99.2 - Bankruptcy Agreement
         Exhibit 99.3 - Sale Agreement

Signature


         After reasonable  inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
correct.


Date: July 19, 1999                                  /s/ Harvey Wm. Glasser
                                                     ---------------------------
                                                     Harvey Wm. Glasser



<PAGE>


                         UNITED STATES BANKRUPTCY COURT
                          FOR THE DISTRICT OF MARYLAND
                              (Greenbelt Division)

In re:                                      )
                                            )
DR. HENRY GRAUSZ, M.D.                      )       Case No. 97-24657-PM
                                            )           (Chapter 11)
                  Debtor-in-possession.     )
- --------------------------------------------)


         Upon the Motion for  Authority to Sell  Cistron  Stock Fee and clear of
Liens,  Claims,  and Other  Interests  (the "Cistron Sale Motion")  filed by Dr.
Henry Grausz, M.D., the debtor and debtor-in-possession  herein ("debtor"),  the
parties hereto hereby stipulate and agree and the Court hereby finds as follows:

         WHEREAS,  on December 29, 1997, (the "Petition  Date") the Debtor filed
in this Court a Petition under Chapter 11 of the Bankruptcy Code commencing this
bankruptcy case (the "Case"); and

         WHEREAS,  the  Debtor  owns  5,558,406  shares of  capital  stock  (the
"Cistron Stock") in Cistron Biotechnology, Inc. ("Cistron"); and

         WHEREAS,  the Cistron  Stock Motion seeks  authority  for the Debtor to
sell 5,058,406  shares of the Cistron Stock (the "Large Block") to Imperial Loan
Management  Corporation ("Imperial Loan") or its designee (the "Imperial Cistron
Stock Purchaser"); and

         WHEREAS,  Imperial  Loan  asserts  and the  Debtor  and  the  Committee
stipulate that Imperial Loan holds a duly-perfected  first-priority  lien in the
Cistron Stock pursuant to a General Security  Agreement  executed by the Debtor,
dated December 21, 1993; and

         WHEREAS,  the  Debtor  is  indebted  to  Imperial  Loan  pursuant  to a
Promissory  Note dated June 10, 1994 in the  original  amount of $250,000  and a
Promissory  Note  dated  April  20,  1995 in the  original  principal  amount of
$250,000,  both as amended by a Modification and/or Extension Agreement dated as
of April 20, 1995, a Modification  and/or Extension  Agreement dated as of April
30, 1996, a Modification  and/or Extension  Agreement dated July 18, 1997, and a
Letter Agreement dated October 23, 1997 (the "1994/1995  Imperial  Notes");  and
(2) a Promissory Note dated August 30, 1996 as extended,  modified,  and amended
by a Letter  Agreement dated October 23, 1997, and two Letter  Agreements  dated
December 23, 1997 (the "1996 Imperial Note"); and

         WHEREAS,  on February 12, 1999, the Court entered its Consent Order (1)
Granting  Debtor's  Motion for Authority to Sell Real Property  Located in Marin
County,  California,  Free and Clear or All Liens,  Claims, and Other Interests;
(2) Granting  Relief From the  Automatic  Stay to Dr.  Harvey  Glasser;  and (3)
granting  Other and Further  Relief With  Respect to  Imperial  Loan  Management
Corporation (the "Consent Order"); and

         WHEREAS,  all  capitalized  terms in this  Order  that are not  defined
herein shall have the meanings given such terms in the Consent Order; and

         WHEREAS, reasonable notice of the Cistron Sale Motion has been provided
to all interested parties,  including without limitation Cistron and all parties
who have claimed a lien on or interest in the Cistron  Stock,  and, by virtue of
the terms of the Cistron Sale Motion,  the Consent  Order (and the notice of the

<PAGE>

motion seeking entry thereof) and the consent of all affected parties, including
the Committee, reasonable notice of the material provisions of this Order and an
opportunity for hearing has also been provided to all interested parties, all in
accordance  with all applicable  requirements of the Federal Rules of Bankruptcy
Procedure and the Bankruptcy Code; and

         WHEREAS, this Order is in the best interests of the Debtor, the Estate,
and the Debtor's  creditors,  and the purchase price and other consideration for
the Cistron  Stock as described in the Cistron Sale Motion and the Consent Order
represents fair and reasonable value to the Debtor and the Estate; and

         NOW THEREFORE, it is hereby

         ORDERED,  that the Cistron Sale Motion be and is hereby  GRANTED as set
forth herein; and it is further

         ORDERED, that the form of agreement providing for the sale of the Large
block to the Imperial Loan Cistron Stock Purchaser attached hereto as Exhibit A,
with such modifications  thereto as to which the Debtor (with the consent of the
Committee) and the Imperial  Cistron Stock Purchaser may agree, be and is hereby
APPROVED, and the Debtor may entered into and execute such agreement;  and it is
further

         ORDERED,  that the  Debtor  may sell the  Large  Block to the  Imperial
Cistron  Stock  Purchaser on the terms and  conditions  described in the Consent
Order and the Cistron Sale Motion; and it is further

         ORDERED,  that, in accordance with the terms of the Consent Order,  the
purchase  price for the Large Block shall be a credit against the balance of the
1996 Imperial Note (and the other consideration set forth in the Consent Order);
and it is further

         ORDERED,  that,  following  the sale of the Large Block to the Imperial
Cistron  Stock  Purchaser,  Imperial  Loan shall  retain  its  claims  under the
1994/1995  Imperial Notes (and its liens on real property of the Debtor securing
those claims) subject to the terms of the Consent Order; and it is further

         ORDERED,  that pursuant to Section 363(f) of the  Bankruptcy  Code, the
sale of the Large Block to the Imperial  Cistron Stock Purchaser as described in
the Cistron  Sale Motion shall be fee and clear of all liens,  claims,  charges,
encumbrances,  and other  interests of any kind of any person or entity,  except
for the rights of the Debtor and the Estate as  described  in the  Cistron  Sale
Motion (and except  that,  at the election of Imperial  Loan and Imperial  Bank,
such sale shall be subject to the continued  lien of Imperial  Bank);  and it is
further

         ORDERED, that Cistron Biotechnology, Inc. and its transfer agent and/or
any other required persons or entities shall take any and all steps necessary to
transfer and/or  reregister or reissue the Cistron Stock upon written request of
the Imperial Cistron Stock Purchaser and/or the Debtor;

         ORDERED,  that  Debtor may execute any  documents  (including,  without
limitation,  a bill of sale)  necessary to effectuate,  and take all actions and
execute all documents  necessary to implement,  the agreement  providing for the
sale of the Cistron Stock; and it is further

         ORDERED and FOUND,  that the Imperial Cistron Stock Purchaser is a good
faith purchaser  under, and is entitled to the protections of, Section 363(m) of
the Bankruptcy Code; and it is further

         ORDERED,  that the Debtor is hereby  authorized to sell the Small Block
(and other stock in Cistron  that the Debtor owns or acquires as a result of any
stock options), or portions thereof, from time to time in the ordinary course of
business in market transactions, or in connection with a sale of the Large Block
as and

<PAGE>

to the extent provided in the Consent Order, provided that the Committee consent
in writing to each such sale; and it is further

         ORDERED,  that this Order is a final and immediately  appealable order.
To the extent  necessary under Bankruptcy Rule 9014, the Court hereby finds that
there is no reason  for delay in the  implementation  of this  Order;  and it is
further

         ORDERED,  that  nothing  in this  Order  shall be deemed to modify  the
Consent Order, which Consent Order shall be deemed incorporated herein.


Dated: March 16, 1999                             /s/ Paul Mannes
                                                  ------------------------------
                                                  United States Bankruptcy Judge

cc:      Bradford F. Englander, Esquire
         1010 Wayne Avenue, 10th Floor
         Silver Spring, Maryland 20910

         Daniel M. Litt, Esquire
         Dickstein, Shapiro Morin & Oshinsky LLP
         2101 L Street, N.W.
         Washington, D.C. 20037-1526

         Philip D. Anker, Esquire
         Wilmer, Cutler & Pickering
         2445 M Street, N.W.
         Washington, D.C. 20037-1429

         Office of the U.S. Trustee
         6305 Ivy Lane, Suite 600
         Greenbelt, Maryland  20770




<PAGE>


This CISTRON STOCK SALE AGREEMENT (this "Agreement") dated as of April 20, 1999,
between DR. HENRY GRAUSZ as debtor in  possession  (the  "seller")  and IMPERIAL
LOAN MANAGEMENT CORPORATION ("Imperial Loan").

         WHEREAS,  the Seller fled a voluntary  petition under Chapter 11 of the
United  States  Bankruptcy  Code on  December  29,  1997,  in the United  States
bankruptcy Court for the District of Maryland, Greenbelt Division (the "court"0;

         WHEREAS, the Seller owns 5,558,406 shares of common stock (the "Cistron
Stock") in Cistron  Biotechnology,  Inc. ("Cistron"),  which has been pledged to
secure certain obligations of Seller to Imperial Loan;

         WHEREAS,  Seller  desires  to  sell  a  portion  of the  Cistron  Stock
aggregating  5,058,406  shares  (the  "large  Block")  to  Imperial  Loan or its
designee  ("0purchaser"0,  subject to the approval of the Court, on the terms et
forth herein;

         WHEREAS,  Seller  has  filed a motion  with the Court to sell the Large
Block, and possibly the Small Block, or a portion  thereof,  pursuant to certain
terms and  conditions  as are set  forth  herein,  free and clear of all  liens,
claims and other  interests,  except as specifically  otherwise  provided in the
Consent Order,  pursuant to Section 363 of the United States Bankruptcy Code and
Rule 6004 of the Federal  Rules of  bankruptcy  Procedure  (the  "Cistron  Stock
Motion"); and

         WHEREAS,  the  parties  desire to  provide  for  certain  undertakings,
conditions,  representations,  warranties,  and covenants in connection with the
transactions contemplated hereby.

         NOW,  THEREFORE,  in  consideration  of the  premises and of the mutual
covenants and agreements herein contained, the parties hereto do hereby agree as
follows:

                                    ARTICLE 1
                                   DEFINITIONS

Section 1.01 Defined terms. All capitalized  terms not otherwise  defined herein
shall  have the  meanings  given such terms in that  certain  Consent  Order (1)
Granting  Debtor's  Motion for Authority to Sell Real Property  Located in Marin
County, California, Free and Clear of All Liens, Claims and Other Interests; (2)
Granting Relief From the Automatic Stay to Dr. Harvey Glasser;  and (3) granting
Other and Further Relief With Respect to Imperial Loan  Management  Corporation,
which was entered on February 12, 1999 by the Court (the "Consent Order").

                                    ARTICLE 2
                          PURCHASE AND SALES OF SHARES

Section 2.01      Sale of Large Block.

                  (a) The  transactions  contemplated by this Agreement shall be
consummated  at a Closing (the  "Closing")  on or before April 23, 1999, or such
other date as the  Seller  and  Purchaser  may agree in  writing  (the  "Closing
Date").

                  (b) [intentionally omitted]

                  (c) At the  Closing,  upon  satisfaction  of,  or  appropriate
waiver of, all of the conditions contained in Article 5 hereof, the Seller shall
sell and deliver to  Purchaser,  and Purchaser  shall  purchase


<PAGE>

from the Seller, 5,058,406 shares (the "Large Block") of common stock in Cistron
in exchange for a credit  against the balance of the 1996  Imperial Note and the
other consideration set forth in the Consent order (the "purchase Price").  Such
sale shall be free of all liens, claims and encumbrances, except as specifically
otherwise  provided in the  consent  Order.  At the  Closing,  the Seller  shall
deliver  to  Purchaser  a bill of  sale or  stock  power,  in a form  reasonably
acceptable  to Purchaser,  evidencing  the sale of the Large Block to Purchaser.
Purchaser  already has  possession  of, or  following  the Closing  shall obtain
possession  of, the  certificates  representing  the Large Block.  Purchaser and
Seller  shall  take  all  reasonable  actions  at  the  Closing  and  thereafter
(excluding  delivering any legal opinions)  necessary to accomplish the transfer
of the Large Block to Purchaser  and the release and delivery of the Small Block
in the name of the Seller, with the certificate for the Large block delivered to
the Purchaser and the certificate for the Small Block delivered to the Seller.

Section 2.02      [Intentionally Omitted]

Section 2.03 Sale of Shares; Application of Proceeds by Purchaser. Following the
Closing,  the parties  shall  comply with the Consent  Order with respect to any
possible  resale of the Large block by Purchaser  within one year  following the
Closing.

                                    ARTICLE 3
                  REPRESENTATIONS AND WARRANTIES OF THE SELLER

         The Seller hereby represents and warrants to Purchaser as follows:

Section 3.01 Warranty of Title to the Large Block.  The Seller has, or will have
as of the Closing,  the ability to transfer  valid and  marketable  title to the
Large  Block to  Purchaser,  pursuant  to an order of the Court,  and,  upon its
transfer to Purchaser pursuant to Section 2.01,  Purchaser will have valid title
to the large Block, free and clear of any pledges,  liens,  security  interests,
options,  restrictions  on  transfer  or  other  encumbrances,   other  than  as
specifically  set forth in the consent Order and those  restrictions on transfer
imposed through acts of Purchaser or by applicable  State or Federal  securities
laws, rules, or regulations.

Section 3.02 Seller's  Disclaimer Of Representations  And Warranties.  Purchaser
acknowledges  and agrees that,  except as expressly stated in this Agreement and
the  Consent  Order,  Seller  has not  made,  does not  make,  and  specifically
disclaims any representations,  warranties,  promises, covenants,  agreements or
guaranties of any kind or character whatsoever, whether express or implied, oral
or written, past, present or future, of, as to, or concerning or with respect to
Cistron or the Cistron Stock. Purchaser further acknowledges and agrees that any
information  provided or to be provided to Purchaser  with respect to Cistron or
the  Cistron  Stock was or will be  obtained  from a variety of sources and that
Seller  has not made  any  independent  investigation  or  verification  of such
information  and makes no  representation  or  warranty as to the  accurancy  or
completeness  of such  information.  Except as provided in this Agreement or the
Consent  Order,  Seller  is not  liable  or bound in any  manner  by any oral or
written statements,  representations,  appraisals, evaluations, reports or other
information  pertaining  to  Cistron  or the  Cistron  Stock  as may  have  been
furnished  to Purchaser  by Seller or his agents or  representatives.  Purchaser
further acknowledges and agrees that to the maximum extent permitted by law, the
sale of the Large Block as provided in this  Agreement is made without  recourse
except  for the  representations  and  warranties  of Seller  contained  in this
Article 3. Purchaser and Seller understand that pursuant to State and/or Federal
securities  laws,  Purchaser may be precluded  from making any transfer or other
disposition  of any of the Large  Block  unless a  specific  exemption  from the
registration   requirements   is  available   with  respect  to  any  particular
transaction.  Purchaser further acknowledges and agrees that the Large block may
bear an  appropriate  restrictive  legend to the effect that the Large Block may
not be sold or transferred  without  registration or the availability of a valid
exemption form  registration,  and that an acceptable  opinion of counsel may be
required by the issuer.

<PAGE>

                                    ARTICLE 4
                 REPESENTATIONS AND WARRANTIES OF THE PURCHASER

         Purchaser hereby represents and warrants to the Seller as follows:

Section 4.01      Authorized and Effective Agreement.

                  (a) Purchaser  has all requisite  power and authority to enter
into and perform all of its obligations under this Agreement.  The execution and
delivery of this  Agreement and  consummation  of the  transaction  contemplated
hereby have been duly and validly  authorized by all necessary action in respect
thereof on the part of Purchaser.  This Agreement constitutes a legal, valid and
binding obligation of Purchaser,  enforceable  against it in accordance with its
terms subject, as to enforceability, to bankruptcy, insolvency and other laws of
general applicability  relating to or affecting creditors' rights and to general
equity principles.

                  (b) Neither the execution and delivery of this Agreement,  nor
consummation  of  the  transactions   contemplated  hereby,  nor  compliance  by
Purchaser with any of the provisions  hereof shall (i) constitute or result in a
breach of any term, condition or provision of, or constitute a default under any
note,  bond,  mortgage,  indenture,  license,  agreement or other  instrument or
obligation by Purchaser,  or (ii) violate any order, writ,  injunction,  decree,
statute, rule or regulation applicable to Purchaser.

Section 4.02      [Intentionally Omitted.]

Section 4.03  Purchaser's  Due  Diligence.  At the time of the execution of this
Agreement and at Closing, Purchaser shall have made such examination, review and
investigation of the facts and  circumstances  necessary to evaluate Cistron and
the Large block as it has deemed  necessary or  appropriate  to form a basis for
its decision to purchase  the Large  Block.  Purchaser is assuming all risk with
respect to the completeness, accuracy, or sufficiency of its examination, review
and  investigation.  Purchaser has agreed to the Purchase  Price on the basis of
its own independent  investigation  and evaluation of Cistron and has not sought
or  relied  upon any  representations,  warranties,  information,  covenants  or
agreements  of  Seller  (other  than the  express  representations,  warranties,
information,  covenants,  and  agreements  set forth in this  Agreement  and the
Consent Order).

Section  4.04  Accredited  Investor.  The  Purchaser  shall  be  an  "accredited
Investor" as such term is defined  under  Section  501(a) of Regulation D of the
Securities Act of 1933 (the "1933 Act").

Section  4.05  Sophistication;  Investment  Intent.  Purchaser,  its  agents and
representatives,  have such  knowledge and  experience in financial and business
matters as to enable them to utilize the  information  made available to them in
connection with the purchases  contemplated  hereby,  to evaluate the merits and
risks of an investment in Cistron and to make an informed  decision with respect
thereto.  Purchaser is acquiring  the Large Block  hereunder  not with a view to
making a  distribution  thereof  within the meaning of the 1933 Act. Such shares
will not be sold or transferred by Purchaser in violation of the securities laws
of the United States or any state thereof or other jurisdiction.

                                    ARTICLE 5
                              CONDITIONS PRECEDENT

Section 5.01      Conditions Precedent - Purchaser and the Seller.


<PAGE>

                  The  respective  obligations of Purchaser and Seller to effect
the  transactions  contemplated  by this  Agreement at the Closing Date shall be
subject to satisfaction or waiver by each party of the following conditions:

                  (a) Neither  Purchaser  nor the Seller shall be subject to any
order, decree or injunction or a court or agency of competent jurisdiction which
enjoins or  prohibits  consummation  of the  transactions  contemplated  by this
Agreement.

                  (b) The court shall have entered an order in a form reasonably
acceptable to the Purchaser,  the Seller and the committee  granting the Cistron
Stock Motion (the  "approval  Order").  Such Approval Order shall remain in full
force and effect and shall not be stayed, modified, rescinded, or revoked.

Section 5.02      Conditions Precedent - the Seller.

                  The  obligations  of the  Seller  to effect  the  transactions
contemplated  by  this  Agreement  at the  Closing  date  shall  be  subject  to
satisfaction of the following  additional  conditions at or prior to the Closing
Date unless waived by the Seller and the Committee:

                  (a) The  representations and warranties of Purchaser set forth
in Article 4 hereof shall be true and correct in all material respects as of the
date of this  Agreement  and as of such Closing Date as though made on and as of
the Closing Date (or on the date when made in the case of any representation and
warranty which  specifically  relates to an earlier  date),  except as otherwise
expressly  provided in this  Agreement  or consented to in writing by the Seller
and the Committee.

                  (b) Purchaser  shall have in all material  respects  performed
all obligations and complied with all covenants required by this Agreement.

Section 5.03      Conditions Precedent - Purchaser.

                  The  obligations  of Purchaser to perform under this Agreement
shall be subject to  satisfaction of the following  additional  conditions at or
prior to the Closing Date unless waived by Purchaser:

                  (a) The representations and warranties of the Seller set forth
in Article 3 hereof shall be true and correct in all material respects as of the
date of this  Agreement  and as of such Closing Date as though made on and as of
the Closing Date (or on the date when made in the case of any representation and
warranty which  specifically  relates to an earlier  date),  except as otherwise
contemplated by this Agreement or consented to in writing by Purchaser.

                  (b) The Seller shall have in all material  respects  performed
all obligations and compiled with all covenants required by this Agreement.

                                    ARTICLE 6
                                  MISCELLANEOUS

Section 6.01 Expenses.  In the event of any disputes  concerning the enforcement
or  interpretation  of this Agreement  whichever party to the dispute which does
not prevail in its  prosecution  or defense of the dispute (the  "Non-Prevailing
Party")  shall   reimburse  the  party  which  prevails  in  such  dispute  (the
"Prevailing  Party")  for  all  expenses  and  for  any  costs  incurred  by the
Prevailing  Party,  including  reasonable  attorney's fees and costs.  Except as
expressly provided in the foregoing sentence,  each party shall bear and pay all



<PAGE>

fees,  expenses and costs that it incurred in connection  with the  transactions
contemplated by this Agreement,  including without limitation, fees and expenses
of its own financial consultants, accountants and counsel.

Section  6.02  Waiver.  Each  party  hereto by such  party (if such  party is an
individual)  or by an  authorized  officer  of such  party  (if  such  party  is
corporation),  and  by  counsel  for  or an  authorized  representative  of  the
Committee,  may at any time  extend the time for the  performance  of any of the
obligations  or other  acts of the other  party  hereto  and may  waiver (i) any
inaccuracies of the other party in the  representations or warranties  contained
in this Agreement or any document  delivered  pursuant  hereto,  (ii) compliance
with any of the  covenants,  undertakings  or agreements of the other party,  or
satisfaction of any of the conditions  precedent to its  obligations,  contained
herein or (iii) the performance by the other party of any of its obligations set
out herein.  No waiver or extension  shall be effective  unless it is in writing
signed by such parties.

Section  6.03  Amendment  or  Supplement.  This  Agreement  may  be  amended  or
supplemented  in writing at any time by mutual  agreement of  Purchaser  and the
Seller, with the written consent of the Committee.  No modification or amendment
of, or supplement  to, this Agreement  shall be effective  unless signed by such
parties.

Section  6.04 Entire  Agreement.  This  Agreement,  the Consent  Order,  and the
Approval Order contain the entire agreement  between the parties with respect to
the  transactions  contemplated  hereunder  and  together  supersede  all  prior
arrangements or understandings with respect thereto, written or oral, other than
documents  referred to herein.  The terms parties hereto,  and their  respective
successors.  Nothing in this  Agreement,  expressed  or implied,  is intended to
confer upon any party,  other than the parties  hereto (and any  Designee),  and
their successors, any rights, remedies, obligations or liabilities.

Section 6.05 No  Assignment.  Imperial Loan may assign its rights subject to its
obligations  under this  Agreement to any person or entity that is an accredited
investor  as  provided  in  Section  4.04  hereof  ("Designee").  Subject to the
limitations  set forth in the Consent  Order,  the Seller may assign his rights,
but not his obligations, under this Agreement.

Section 6.06 Notices.  All notices or other communications which are required or
permitted  hereunder shall be in writing and sufficient if delivered  personally
or sent by  overnight  express,  or by  registered  or certified  mail,  postage
prepaid, addressed as follows:

                  If to the Seller:

                           Dr. Henry Grausz
                           101 Lounsbury Place
                           Falls Church, Virginia  22046

                  With a required copy to:

                           Bradford F. Englander, Esq.
                           Linowes and Blocher LLP
                           Tenth Floor
                           1010 Wayne Avenue
                           Silver Spring, Maryland  20910


<PAGE>

                  If to Purchaser:

                           Imperial Loan Management Corporation
                           c/o Peter Schneider
                           18150 Cottonwood Road, #423
                           Sunriver, Oregon 97707
                           Fax: (541) 593-3399

                           Dr. Harvey Wm. Glasser
                           c/o Western Property Holdings
                           2000 Powell Street, Suite 1650
                           Emeryville, California  94608
                           Fax: (510) 601-8631

                  With a required copy to:

                           Phillip D. Anker, Esq.
                           Wilmer, Cutler & Pickering
                           2445 M Street, NW
                           Washington, DC  20037-1420

                  If to the Committee:

                           Daniel M. Litt, Esq.
                           Diskstein, Shapiro, Morin & Oshinsky
                           2101 L Street, NW
                           Washington, DC  20037

Section  6.07  Captions.  The  captions  contained  in  this  Agreement  are for
reference purposes only and are not part of this Agreement.

Section  6.08  Severability.  If  any  provision  of  this  Agreement  shall  be
determined  illegal  or  unenforceable  by  any  court  of  law,  the  remaining
provisions shall be severable and enforceable in accordance with their terms.

Section  6.09  Counterparts.  This  Agreement  may be  executed in any number of
counterparts,  and each  such  counterpart  shall be  deemed  to be an  original
instrument,  but  all  such  counterparts  together  shall  constitute  but  one
agreement.

Section 6.10 Time of the Essence.  The parties  hereto agree that time is of the
essence.

Section 6.11 Jury Trial Waiver.  THE PARTIES HERTO AGREE TO WAIVE ANY RIGHT THEY
MAY HAVE TO A TRIAL BY JURY OF ANY ISSUES RAISED IN ANY ACTION ALLEGING A BREACH
OF THIS AGREEMENT.

Section 6.12  Governing  Law and  Jurisdiction.  The validity,  enforcement  and
interpretation  of this Agreement  shall be governed by the laws of the State of
Maryland  without  giving  effect to the  conflict of laws  principles  thereof,
except to the extent that the bankruptcy Code controls.

Section 6.13 Court Orders.  In the event that there is any conflict between this
Agreement  and the Consent  Order and/or the Approval  Order,  the terms of such
orders shall take precedence.

                            [SIGNATURE PAGE FOLLOWS]


<PAGE>

IN WITNESS  WHEREOF,  the parties hereto have signed,  executed and entered into
this Agreement, under seal, all as of the day and year first above written.

                           IMPERIAL LOAN MANAGEMENT CORPORATION



                           By: /s/ Peter Schneider                   [SEAL]
                               -------------------------------
                           Name: Peter Schneider
                                 -----------------------------
                           Title: President
                                  ----------------------------


                           /s/ Henry Grausz
                           -----------------------------------
                           Dr. Henry Grausz, as debtor in possession [SEAL]

                              Purchaser Designation

Imperial Loan Management Corporation hereby designates Dr. Harvey Wm. Glasser as
the "Purchaser" and Designee," and Dr. Glasser hereby joins in this Agreement as
Purchaser and Designee, acknowledges and accepts such designation, and agrees to
be bound by the terms hereof that are binding upon  Purchaser,  and confirms the
representations and warranties of Purchaser as set forth above.

                           IMPERIAL LOAN MANAGEMENT CORPORATION



                           By: /s/ Peter Schneider                  [SEAL]
                               --------------------------------
                           Name: Peter Schneider
                                 ------------------------------
                           Title: President
                                  -----------------------------


                           /s/ Harvey Wm. Glasser
                           ------------------------------------
                           Dr. Harvey Wm. Glasser



<PAGE>


                               PURCHASE AGREEMENT

         This PURCHASE  AGREEMENT (the  "Agreement") is made and entered into as
of June 21, 1999, by and among Dr. Harvey Wm.  Glasser  ("Glasser")  and Cistron
Biotechnology, Inc., a Delaware corporation ("Cistron").

                                   WITNESSETH:

         WHEREAS,  Glasser  acquired  5,058,406  shares (the "Shares") of common
stock, par value $0.01 of Cistron (the "Common Stock"), pursuant to that certain
Cistron Stock Sale  Agreement  dated as of April 20, 1999 (the  "Original  Stock
Sale Agreement") between Dr. Henry Grausz as debtor in possession (the "Debtor")
and Imperial Loan  Management  Corporation  (Imperial  Loan"),  and that certain
Irrevocable  Stock Power and  Assignment  dated  April 20, 1999  executed by the
Debtor (the "Irrevocable Stock Power");

         WHEREAS,  the  Debtor's  sale of the Shares to Glasser and the Original
Stock Sale Agreement were approved by the United States Bankruptcy Court for the
District of Maryland  (the  "Bankruptcy  Court")  pursuant to that certain Order
Grating  Debtor's  Motion for  Authority to Sell Cistron  Stock Fee and Clear of
Liens,  Claims,  and Other  Interests  dated  March  16,  1999,  entered  by the
Bankruptcy Court in the pending  bankruptcy case of the Debtor,  In re Dr. Henry
Grausz,  M.D., Case No.  97-24657 (PM) (the "March 16 Order"),  and that certain
Consent Order (1) Granting  Debtor's  Motion for Authority to Sell Real Property
Located in Marin  County,  California,  Free and Clear of all Liens,  Claims and
Other  Interests;  (2) Granting  Relief from the  Automatic  Stay to Dr.  Harvey
Glasser; and (3) Granting Other and Further Relief with Respect to Imperial Loan
Management Corporation dated February 12, 1999 (the "Consent Order");

         WHEREAS, as provided in the March 16 Order, Glasser acquired the Shares
fee and clear of all liens other than the continued  liens of Imperial Bank (the
"Imperial Lien");

         WHEREAS,  the bankruptcy estate of the Debtor (the "Estate")  continues
to own 500,000 shares of Common Stock (the "Estate Shares");

         WHEREAS,   the  Original   Stock  Sale  Agreement  is  subject  to  the
requirement  described in the Consent Order that if Glasser sells all or part of
the Shares  during the year  following  the closing of the  Original  Stock Sale
Agreement,  Glasser  shall  require that any  purchaser  offer the Estate,  with
respect to the Estate  Shares,  the  opportunity  to participate on the same per
share terms in such sale;

         WHEREAS,  Glasser  desires to sell the Shares  and  Cistron  desires to
purchase  the  Shares,  upon the terms and  subject to the  conditions  et forth
herein,  in  consideration  of the payment by Cistron of the Purchase  Price (as
defined in Section 1.2 below); and

         WHEREAS,  Cistron  agrees to offer to the Estate to purchase the Estate
Shares on the terms and conditions set forth herein (the "Cistron Offer");

         NOW,  THEREFORE,  in  consideration  of the  foregoing  and the  mutual
covenants  and   agreements   contained   herein  and  other  good  an  valuable
consideration,  the receipt and sufficiency of which is hereby acknowledged, the
parties,  upon the terms and subject to the conditions contained herein,  hereby
agree as follows:

1.   Purchase of the Shares and Payment of the Purchase Price.
<PAGE>

     1.1  Subject to the terms and conditions  hereof,  Cistron hereby agrees to
          purchase from Glasser the Shares and Glasser agrees to sell to Cistron
          the Shares with stock powers executed in blank.

     1.2  Subject to the terms and conditions hereof,  Cistron shall deliver and
          pay to  Glasser in  consideration  for the  Shares an  aggregate  cash
          purchase  price of One  Million  One Hundred  Fifty  Thousand  Dollars
          ($1,150,000) (the "Purchase Price"), or $0.2274 per share.

     1.3  The Purchase  Price for the Shares shall be paid by Cistron at Closing
          (as defined below) in immediately  available funds by wire transfer to
          an account or  accounts  designated  by Glasser.  At Closing,  Glasser
          shall cause such  portion of the  Purchase  Price as he is required to
          transfer  to the  Estate  under the terms of  paragraph  no. 28 of the
          Consent Order to be so transferred  and shall cause such amount of the
          remainder of the Purchase  Price as may be necessary to cause Imperial
          Bank to release the Imperial Lien to be transferred to Imperial Bank.

2.   Closing.

     2.1  The closing (the "Closing") of the transaction  contemplated hereunder
          shall occur two business  days after all the  conditions  set forth in
          Sections 5 and 6 below are satisfied or waived,  but in no event shall
          Closing  occur (x) earlier than five (5) business  days after  Cistron
          provides  notice  by  facsimile  to the  Estate of the  Cistron  Offer
          pursuant to Section 7.3 of this  Agreement  or (y) later than July 16,
          1999, at the offices of Epstein Becker & Green,P.C., 1227 25th Street,
          N.W.,  Washington,  DC 20037-1156,  unless  otherwise agreed to by the
          parties.

     2.2  At the  Closing,  upon  satisfaction  of all  conditions  set forth in
          Sections  5 and 6 below,  (i)  Glasser  shall  deliver  or cause to be
          delivered to Cistron stock certificates  representing the Shares, with
          stock powers  executed in blank,  and (ii) Cistron  shall  deliver the
          Purchase  Price to Glasser (or to such  account or accounts as Glasser
          may designate pursuant to Section1.3 above).

3.   Representations  and Warranties of Cistron.  Cistron hereby  represents and
     warrants to Glasser as follows:

     3.1  Cistron has: (i) been duly  organized  and is validly  existing and in
          good  standing  under  the  laws of the  State of  Delaware;  (ii) all
          requisite  capacity,  power and  authority to enter into,  deliver and
          perform this Agreement; and (iii) all requisite power and authority to
          own and  operate  its  properties  and  assets,  and to  carry  on its
          business,  as  presently  conducted  and as proposed to be  conducted.
          Cistron is duly qualified to conduct business in the  jurisdictions in
          which the nature of its business or the  ownership of its assets makes
          such  qualification  necessary  except where the failure to so qualify
          has not had and would not have,  individually  or in the aggregate,  a
          material  adverse  effect on the financial  condition or operations of
          Cistron.

     3.2  All  corporate  action  on the  part  of  Cistron  necessary  for  the
          authorization,  execution,  delivery and performance of this Agreement
          has been taken. This Agreement has been duly and properly executed and
          delivered by Cistron, and constitutes valid and binding obligations of
          Cistron, enforceable in accordance with its terms.
<PAGE>


     3.3  The execution and delivery of this  Agreement by Cistron does not, and
          the   consummation  of  the  transactions   contemplated   hereby  and
          compliance with the terms hereof will not,  conflict with or result in
          any violation, loss of rights,  termination or breach of or constitute
          a material  default  (or an event  which  with the  passage of time or
          giving of notice,  or both, would constitute a material default) under
          (i) any provision of the  Certificate  of  Incorporation  or Bylaws of
          Cistron,  (ii) any judgment,  order, decree,  statute, law, ordinance,
          rule or regulation  applicable to Cistron or the property or assets of
          Cistron or (iii) any agreement, deed, contract,  mortgage,  indenture,
          writ, order,  decree,  legal obligation or instrument to which Cistron
          is a party or to which any of its  assets or  properties  is or may be
          subject.  The execution and delivery of this Agreement by Cistron does
          not, and the consummation of the transactions  contemplated hereby and
          compliance  with the terms  hereof  and of such other  agreements  and
          instruments will not, result in the creation or imposition or, or give
          any  party  the  right to  create  or  impose,  any  lien,  charge  or
          encumbrance,  or restriction of any nature  whatsoever with respect to
          any  material  properties  or assets of  Cistron  or give to any other
          person  any  interest  or  rights,  including  rights of  termination,
          acceleration  or  cancellation  in,  or with  respect  to,  any of the
          properties, assets or agreements of Cistron. No notification, consent,
          approval,  order or authorization of, or registration,  declaration or
          filing with, any court,  administrative  agency or commission or other
          governmental  authority or  instrumentality,  domestic or foreign,  or
          with any other  person or entity is required to be obtained or made by
          or with  respect to  Cistron  in  connection  with the  execution  and
          delivery  of this  Agreement  or the  consummation  by  Cistron of the
          transactions contemplated hereby.

     3.4  As of the date hereof,  Cistron has made such examination,  review and
          investigations  of the facts and  circumstances  necessary to evaluate
          the Shares as it has deemed  necessary or  appropriate to form a basis
          for its decision to pay the Purchase Price and purchase the Shares.

     3.5  Cistron is  acquiring  the Shares with the intent of having the Shares
          become  treasury  stock and not with a view to  making a  distribution
          thereof  within the meaning of the  Securities  Act of 1933 (the "1933
          Act").  Cistron is an  "Accredited  Investor"  as such term is defined
          under Section 501(a) of Regulation D of the 1933 Act. Cistron will not
          sell or transfer  the Shares in violation of the 1933 Act or any other
          securities  laws of the  United  States or any state  thereof or other
          jurisdiction.

4.   Representations  and Warranties of Glasser.  Glasser hereby  represents and
     warrants to Cistron as follows:

     4.1  Glasser has the full legal  right,  power and  authority to enter into
          this  Agreement and this Agreement  constitutes  the valid and binding
          obligation of Glasser, enforceable in accordance with its terms.

     4.2  Except for the Imperial Lien and  Glasser's  obligation to transfer to
          the estate a portion  of the  proceeds  realized  from the sale of the
          Shares  hereunder  as set forth in  paragraph  no.  28 of the  Consent
          Order,  the execution  and delivery of this  Agreement by Glasser does
          not, and the consummation of the transactions  contemplated hereby and
          compliance with the terms hereof will not,  conflict with or result in
          any violation, loss or rights,  termination or breach of or constitute
          a material  default  (or an event  which  with the  passage of time or
          giving of notice,  or both, would constitute a material default) under
          (i) any judgment, order,



<PAGE>

          decree,  statute,  law,  ordinance,  rule or regulation  applicable to
          Glasser or the  property  or assets of  Glasser  or (ii) any  material
          agreement, deed, contract,  mortgage,  indenture, writ, order, decree,
          legal obligation or instrument to which Glasser is a party or to which
          any of his assets or properties  is or may be subject.  Except for the
          release of the  Imperial  Lien and the notice of the Cistron  Offer as
          provided in Section 7.3 hereof,  no notification,  consent,  approval,
          order or  authorization  of, or  registration,  declaration  or filing
          with,  any  court,   administrative  agency  or  commission  or  other
          governmental  authority or  instrumentality,  domestic or foreign,  or
          with any other  person or entity is required to be obtained or made by
          or with  respect to  Glasser  in  connection  with the  execution  and
          delivery  of this  Agreement  or the  consummation  by  Glasser of the
          transactions contemplated hereby and thereby.

     4.3  Except for (i) the Imperial Lien, (ii) Glasser's  obligation to pay to
          the Estate a portion  of the  proceeds  realized  from the sale of the
          Shares  hereunder  as set forth in  paragraph  no.  28 of the  Consent
          Order,  and (iii)  the  Estate's  "drag-along"  rights as set forth in
          paragraph  no. 27 of the  Consent  Order,  Glasser  acquired  from the
          Debtor  and owns the Shares  free and clear of all  liens,  claims and
          encumbrances;  provided, however, Glasser may have certain obligations
          to seek to sell the Shares  and to apply  some or all of the  Purchase
          Price, less the portion thereof that he is required under the terms of
          paragraph no. 28 of the Consent Order to transfer to the estate, is in
          satisfaction  of the  Imperial  Lien  and/or  certain  other  debts or
          Imperial  Loan.  At  Closing,  Glasser  shall  transfer  the Shares to
          Cistron  free and clear of all liens,  claims and  encumbrances  other
          than any liens, claims and encumbrances  created by or arising through
          Cistron.

     4.4  Except as expressly  stated in this  Agreement,  Glasser has not made,
          does  not  make,  and  specifically   disclaims  and  representations,
          warranties,  promises, covenants, agreements or guaranties of any kind
          or character whatsoever,  whether express or implied, oral or written,
          past,  present or future,  of, as to, or concerning or with respect to
          Cistron or the Shares, or the value thereof.

     4.5  As of the date hereof,  Glasser has made such examination,  review and
          investigations  of  the  facts  and  circumstances  as he  has  deemed
          necessary  to form a basis  for his  decision  to sell the  Shares  in
          exchange for the Purchase Price.

5.   Conditions to Cistron's  Closing.  The obligations of Cistron Hereunder are
     subject to the  following  conditions,  each of which must be  satisfied or
     waived by Cistron prior to Closing:

     5.1  Representations   and  Warranties   True.  All   representations   and
          warranties of Glasser contained in this Agreement shall be true in all
          material respects at and as of the Closing as if such  representations
          and warranties  were made at and as of the Closing,  and Glasser shall
          have  performed and satisfied all material  agreements in all material
          respects as required by this  Agreement to be performed  and satisfied
          by Glasser at or prior to the Closing.

     5.2  Certificates.  At the Closing,  Glasser shall deliver,  or cause to be
          delivered, to Cistron stock certificates representing the Shares, with
          stock powers executed in blank with medallion guarantees.

     5.3  No  Order.  Cistron  shall  not be  subject  to any  order,  decree or
          injunction  of a court  or  agency  of  competent  jurisdiction  which
          enjoins or prohibits consummation of the transactions  contemplated by
          this Agreement.

     5.4  Other  Documents.  Glasser shall deliver a copy of the Original  Stock
          Sale  Agreement,  and copies of the March 16 Order and Consent  Order,
          which orders are in full force and effect.

<PAGE>

     5.5  Release of Imperial Lien. Glasser shall provide evidence that Imperial
          Bank has  terminated  and  released  the  Imperial  Lien on the Shares
          effective at Closing and the payment by Cistron of the Purchase  Price
          as provided in Section 1.3 above.

     5.6  Opinion.  Cistron shall have received from Wilmer, Cutler & Pickering,
          counsel to Glasser, an opinion addressed to Cistron, dated the Closing
          Date, in substantially the form attached hereto as Exhibit A.

     5.7  Affidavit from Linowes and Blocher LLP. Cistron shall have received an
          affidavit  from Linowes and Blocher LLP attesting to the  authenticity
          and genuineness of Grausz's signature on the Irrevocable Stock Power.

     5.8  Resolution  of Board of  Directors.  The Board of Directors of Cistron
          shall  have  adopted  a  resolution  indemnifiying  Continental  Stock
          Transfer & Trust Company for the transfer of the Shares.

6.   Conditions to Glasser's  Closing.  The obligations of Glasser hereunder are
     subject to the  following  conditions,  each of which must be  satisfied or
     waived by Glasser prior to Closing:

     6.1  Resolutions.  Prior to or at  Closing,  Glasser  shall  have  received
          resolutions  of the Board of  Directors  of  Cistron  authorizing  and
          approving the transactions  contemplated by this Agreement,  certified
          by the  respective  Secretary of Cistron,  together with a certificate
          issued by the Delaware  Secretary of State  showing that Cistron is in
          good standing and authorized to do business.

     6.2  Representations   and  Warranties   True.  All   representations   and
          warranties of Cistron contained in this Agreement shall be true in all
          material   respects   as  at  and  as  of  the   Closing  as  if  such
          representations and warranties were made at and as of the Closing, and
          Cistron shall have performed and satisfied all material  agreements in
          all  material  respects as required by this  Agreement to be performed
          and satisfied by Cistron at or prior to the Closing.

     6.3  No  Order.  Glasser  shall  not be  subject  to any  order,  decree or
          injunction  of a court  or  agency  of  competent  jurisdiction  which
          enjoins or prohibits consummation of the transactions  contemplated by
          this Agreement.

     6.4  Other  Deliveries.   Cistron  shall  have  delivered  such  additional
          instruments,  as may be reasonably necessary or advisable to carry out
          Cistron's  obligations  under,  and to fulfill  the  purpose  of, this
          Agreement and any other  document,  certificate or other  instructions
          delivered pursuant hereto.

     6.5  Receipt of Purchase Price. Cistron shall have wired the Purchase Price
          to an account or accounts designated by Glasser as provided in Section
          1.3 above.

     6.6  Cistron Offer.  Cistron shall have made (and shall not have withdrawn)
          the Cistron Offer to the Estate as provided in Section7.3 below.

     6.7  Release of Imperial  Lien.  Imperial  Bank shall have  terminated  and
          released the Imperial Lien on the Shares  effective at Closing and the
          payment by Cistron of the  Purchase  Price as  provided in Section 1.3
          above.

<PAGE>

     6.8  Transfer.  Continental Stock Transfer and Trust Company,  the transfer
          agent for Cistron,  shall have confirmed,  in writing (a copy of which
          writing   shall  be  provided  to  Glasser  and  his   counsel),   the
          transferability of the Shares from Glasser to Cistron pursuant to this
          Agreement without registration pursuant to the 1933 Act. To the extent
          required by  Continental to so confirm,  counsel to Cistron,  Epstein,
          Becker & Green,  P.C.,  shall have provided an opinion to Continental,
          dated  the  Closing  date,  that  registration  of the  Shares  is not
          required  under the 1933 Act for the  transfer of the Shares set forth
          in the prior sentence of this Section.

     6.9  Stock  Power.   Glasser  shall  have  received  from  the  Debtor  the
          Irrevocable Stock Power with a signature  guarantee from Cistron,  and
          Cistron  shall have  provided to  Continental  Stock  Transfer & Trust
          Company the documentation set forth in Exhibit B attached hereto.

7.   Covenants.

     7.1  Expenses.  Each  party  shall  bear the  legal,  accounting  and other
          expenses incurred by such party in connection with this Agreement, and
          the transactions contemplated hereby.

     7.2  Further  Assurances.  Each of Glasser and Cistron  covenant  and agree
          that,  subsequent to the execution and delivery of this  Agreement and
          without  any  additional  consideration,  each of Glasser  and Cistron
          shall  execute and deliver any further legal  instruments  and perform
          such acts which are or may become necessary to effectuate the purposes
          of this  Agreement,  and shall  cooperate  with the transfer agent for
          Cistron as may be  necessary to  recertificate  the Shares to evidence
          the transfer of the Shares to Cistron.

     7.3  Drag-Along Rights. On the date hereof,  Cistron shall make an offer to
          purchase  the  Estate  Shares  from the  Estate on the same  terms and
          conditions, including price per share of Common Stock, $0.2274, for an
          aggregate  purchase  price to be paid by  Cistron to the Estate of One
          Hundred  Thirteen  Thousand  Seven  Hundred  Dollars  ($113,700)  (the
          "Cistron Offer"). On the date hereof,  Cistron shall deliver a notice,
          in a form  reasonably  acceptable  to Glasser,  to the Estate  setting
          forth the terms of the sale and the expected  date of Closing.  On the
          date hereof, Cistron shall cause copies of such notice to be delivered
          to Bradford E. Englander at facsimile  301-495-9044 and Daniel M. Litt
          at facsimile 202-887-0689.

8.   Indemnification.

     8.1  The  representations  and  warranties  and covenants set forth in this
          Agreement  will  survive  until  the  second  anniversary  of the date
          hereof,  and upon such second  anniversary,  all  representations  and
          warranties and covenants and all claims not yet asserted based thereon
          shall expire.

     8.2  Cistron  hereby  agrees to indemnify  Glasser and to hold him harmless
          from and against any and all losses,  expenses,  liabilities,  claims,
          demands  and  judgments  (including,  without  limitation,  reasonable
          attorneys' fees) arising out of, resulting from or relating to (i) the
          breach by Cistron of any representation or warranty made by Cistron in
          this  Agreement or (ii) the breach of any covenant or agreement or the
          non-performance  of any  obligation  or  covenant  set  forth  in this
          Agreement required to be performed by Cistron.

     8.3  Glasser  hereby  agrees to  indemnify  Cistron and to hold it harmless
          from and against any and all losses,  expenses,  liabilities,  claims,
          demands  and  judgments  (including,  without  limitation,  reasonable
          attorneys' fees) arising out of, resulting from or relating to (i) the

<PAGE>

          breach by Glasser of any representation or warranty made by Glasser in
          this  Agreement or (ii) the breach of any covenant or agreement or the
          non-performance  of any  obligation  or  covenant  set  forth  in this
          Agreement required to be performed by Glasser.

     8.4  The  provisions of this Section8  shall apply to any claim,  action or
          proceeding   (a  "Claim")   for  which  any  person  or  entity  seeks
          indemnification under this Agreement.

          (a)  The party seeking indemnification (the "Indemnified Party") shall
               give  prompt  notice  to  the  party  from  whom  it  is  seeking
               indemnification  (the "Indemnifying  Party") of such Claim, which
               notice shall include such information relating to the Claim as is
               known by the Indemnified Party of any indemnification  obligation
               in respect  to such  Claim,  except to the extent any  failure or
               delay materially  prejudices the right of the Indemnifying  Party
               to defend  such  Claim.  The  Indemnifying  Party  shall have the
               right,   upon   acknowledging  in  writing  its   indemnification
               obligations  hereunder,  to defend  such Claim at its  expense by
               giving  written  notice of such  election  within  30 days  after
               receipt of such notice from the Indemnified Party. The failure of
               the Indemnifying Party to notify the Indemnified Party of whether
               it elects to exercise  its right to defend such Claim within such
               30 day  period  shall be deemed an  election  not to defend  such
               Claim.

          (b)  If  the  Indemnifying  Party  acknowledges  its   indemnification
               obligations  and  elects  to  defend  the  Claim,  the  remaining
               provisions of this  paragraph (b) shall apply.  The  Indemnifying
               Party  shall  promptly  and  diligently  pursue  the  defense  or
               settlement  of the Claim.  The  Indemnified  Party shall  provide
               reasonable  assistance to the Indemnifying Party. The Indemnified
               Party shall have the right to  participate  in such defense,  but
               any counsel employed by the Indemnified Party shall thereafter be
               at its expense and the Indemnifying  Party shall retain the right
               to control  the  defense of such Claim.  The  Indemnifying  Party
               shall have the right in its sole  discretion to settle such Claim
               if the  settlement  involves  only  the  payment  of money by the
               Indemnifying Party and the execution of appropriate releases. Any
               other settlement of such Claim,  including,  without  limitation,
               any settlement involving non-monetary consideration or admissions
               of  wrongdoing,  shall not be settled  without the prior  written
               consent of the  Indemnified  Party,  which  consent  shall not be
               unreasonably withheld.

          (c)  If   the   Indemnifying    Party   does   not   acknowledge   its
               indemnification  obligations or elects not to defend a Claim, the
               remaining  provisions  of this  subsection  (c) shall apply.  The
               Indemnified  Party  shall have the right to defend such Claim and
               to  settle  such  Claim  on  terms  and   conditions   reasonably
               acceptable to the Indemnified Party. If the Indemnifying Party is
               obligated to indemnify the  Indemnified  Party in respect of such
               Claim under this Agreement, the Indemnifying Party shall have the
               indemnity and  reimbursement  obligations  provided  elsewhere in
               this Agreement.

9.   Termination

     9.1  This  Agreement may be terminated by Glasser or Cistron if the Closing
          shall not have been consummated on or before July ___, 1999.

     9.2  In the event of termination of this Agreement pursuant to Section 9.1,
          written notice thereof shall forthwith be given to Glasser or Cistron,
          as the case may be, and this Agreement shall terminate without further
          action by any of the parties hereto.
<PAGE>

10.  Miscellaneous.

     10.1 This  Agreement  will be binding  upon and inure to the benefit of the
          parties   hereto   and   their   respective   successors   and   legal
          representatives.

     10.2 Cistron   acknowledges   and  agrees  that  the  Shares  may  bear  an
          appropriate  restrictive  legend to the effect that the Shares may not
          be sold or transferred  without  registration or the availability of a
          valid exemption from  registration,  and that an acceptable opinion of
          counsel for the issuer may be required.

     10.3 This  Agreement  constitutes  the entire  agreement  among the parties
          regarding  the subject  matter  hereof.  All prior or  contemporaneous
          agreements,  proposals,  understandings and  communications  among the
          parties,  whether oral or written related to the subject matter hereof
          are superseded by and merged into this  Agreement.  This Agreement may
          not be modified or amended except by a written instrument  executed by
          all the parties hereto.

     10.4 If any provision of this  Agreement is held to be invalid,  illegal or
          unenforceable  for any reason or in any respect,  it shall be adjusted
          rather than voided, if possible, in order to achieve the intent of the
          parties to this Agreement to the extent  possible.  In any event,  all
          other  provisions of this Agreement  shall be deemed valid,  legal and
          enforceable to the fullest extent possible.

     10.5 All  notices,  consents  and other  communications  hereunder  will be
          provided in writing and will be delivered personally, by registered or
          certified  mail (return  receipt  requested) or by  facsimile,  to the
          parties at the  respective  addresses  set forth  below (or such other
          address  as may have  been  furnished  by or on behalf of any party by
          like notice).

                           If to Cistron:

                           Cistron Biotechnology, Inc.
                           10 Bloomfield Avenue
                           Pine Brook, New Jersey 07058
                           Attention: Chief Executive Officer
                           Fax: (973) 575-4854

                           with a copy to:

                           Epstein Becker & Green, P.C.
                           250 Park Avenue
                           New York, New York 10177
                           Attention: Seth I. Truwit, Esquire
                           Facsimile: (212) 661-0989

                           If to Glasser:

                           Dr. Harvey Wm. Glasser
                           c/o Western Property Holdings
                           2000 Powell Street, Suite 1650
                           Emeryville, California 94608
                           Fax: (510) 601-8631
<PAGE>

                           and with a copy to:

                           Wilmer, Cutler & Pickering
                           2445 M Street, N.W.
                           Washington, DC 20037
                           Attention: Philip D. Anker,Esquire
                           Fax: (410) 986-2828

Communications  sent  by  facsimile  will  be  deemed  effectively  served  upon
dispatch, transmission confirmed. Communications sent by registered or certified
mail will be deemed  effectively  served seven (7) calendar days after  mailing.
Communications  delivered by hand or overnight couriers will be deemed effective
upon delivery.

     10.6  In the  event  of  litigation  between  the  parties  regarding  this
           Agreement,  the losing party shall reimburse the prevailing party for
           its reasonable costs and attorneys' fees.

     10.7  No  waiver  by any  party  of a  breach  of any  term,  provision  or
           condition  of this  Agreement  by the other party will  constitute  a
           waiver of any  succeeding  breach of the same or any other  provision
           hereof.  No such waiver will be valid  unless  executed in writing by
           the party making the waiver.

     10.8  This  Agreement  shall be governed by and  construed  and enforced in
           accordance  with the laws of the State of  Delaware,  without  giving
           effect  to the  conflict  of  laws  principles  thereof.  Each of the
           parties  hereto  (a)  consents  to  submit  itself  to  the  personal
           jurisdiction of any federal court located in the State of Delaware or
           any Delaware state court if a dispute arises out of this Agreement or
           any of the  transactions  contemplated  by  this  Agreement,  and (b)
           agrees  that it will not  attempt  to deny or  defeat  such  personal
           jurisdiction  by motion  or other  request  for  leave  from any such
           court.

     10.9  This Agreement may be executed in any number of counterparts, each of
           which will be deemed an original and all of which taken together will
           constitute one and the same document.

     10.10 Nothing  expressed  or  implied  herein  is  intended,  or  shall  be
           construed,  to confer  upon or give any  person or entity  other than
           Cistron and  Glasser,  any rights or  remedies  under or by reason of
           this  Agreement;  provided,  however,  that the Estate is an intended
           third-party beneficiary under Section 7.3.

     10.11 The parties agree that time is of the essence.

     10.12 THE PARTIES  HERETO AGREE TO WAIVE ANY RIGHT THEY MAY HAVE TO A TRIAL
           BY JURY OF ANY ISSUES RAISED IN ANY ACTION  ALLEGING A BREACH OF THIS
           AGREEMENT.

     10.13 The  captions  and  headings  contained  in  this  Agreement  are for
           reference purposes only and are not part of this Agreement.


                            [Signature page follows]


<PAGE>


                        PURCHASE AGREEMENT SIGNATURE PAGE


         IN WITNESS WHEREOF,  the parties hereto have executed this Agreement as
of the date first set forth above.

CISTRON BIOTECHNOLOGY, INC.


By: /s/ Franklin J. Iris
- --------------------------------------
Name:    Franklin J. Iris
Title:   Chairman and CEO


DR. HARVEY WM. GLASSER


/s/ Harvey Wm. Glasser, MD
- --------------------------------------




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