THERMO INSTRUMENT SYSTEMS INC
S-3, 1996-04-02
MEASURING & CONTROLLING DEVICES, NEC
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                   As filed with the Securities and Exchange 
                          Commission on March 29, 1996
                                               Registration No. 333-_____
                                                                         

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C.  20549
                               __________________

                                    FORM S-3 
                             Registration Statement
                                      Under
                           The Securities Act of 1933
                               __________________

                         THERMO INSTRUMENT SYSTEMS INC.
             (Exact name of registrant as specified in its charter)

                               ------------------

                  Delaware                                04-2925809
        (State or other jurisdiction of                (I.R.S. Employer
        incorporation or organization)                Identification No.)

                               ------------------

                                504 Airport Road
                              Post Office Box 2108
                        Santa Fe, New Mexico  87504-2108
                                 (505) 438-3171
          (Address, including zip code, and telephone number, including
            area code, of registrant's principal executive offices) 
                               __________________

                          Sandra L. Lambert, Secretary
                         Thermo Instrument Systems Inc.
                         c/o Thermo Electron Corporation
                                 81 Wyman Street
                                 P. O. Box 9046
                             Waltham, MA  02254-9046
                                 (617) 622-1000
            (Name, address, including zip code, and telephone number,
                   including area code, of agent for service)

                                   Copies to:
                           Seth H. Hoogasian, Esquire
                                 General Counsel
                         Thermo Instrument Systems Inc.
                         c/o Thermo Electron Corporation
                                 81 Wyman Street
                       Waltham, Massachusetts 02254-9046 
                              ______________________

             Approximate date of commencement of proposed sale to the
        public:  As soon as practicable after the Registration Statement
        has become effective.
PAGE
<PAGE>






             If the only securities being registered on this form are
        being offered pursuant to dividend or interest reinvestment
        plans, please check the following box.  [   ]

             If any of the securities being registered on this form are
        to be offered on a delayed or continuous basis pursuant to Rule
        415 under the Securities Act of 1933, other than securities
        offered only in connection with dividend or interest reinvestment
        plans, please check the following box.   [ x ]  

                               __________________

                         CALCULATION OF REGISTRATION FEE

                                   Proposed
          Title of                  Maximum     Proposed
         securities     Amount     Offering     Maximum      Amount of
            to be        to be     Price Per   Aggregate    Registration
         registered   registered     Share   Offering Price     Fee

        Common Stock,
          $.10 par      96,029                                    
          value per     shares     $29 9/16  $2,838,858(1)    $979 (1)
           share                      (1)

        (1)  Estimated solely for the purpose of calculating the amount
             of the registration fee pursuant to Rule 457(c) based on the
             average of the high and low sales prices of the Common Stock
             on the American Stock Exchange on March 27, 1996.


                            -------------------------


             THE REGISTRANT HEREBY AMENDS THIS REGISTRATION STATEMENT ON
        SUCH DATE OR DATES AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE
        DATE UNTIL THE REGISTRANT SHALL FILE A FURTHER AMENDMENT WHICH
        SPECIFICALLY STATES THAT THIS REGISTRATION STATEMENT SHALL
        THEREAFTER BECOME EFFECTIVE IN ACCORDANCE WITH SECTION 8(A) OF
        THE SECURITIES ACT OF 1933 OR UNTIL THIS REGISTRATION STATEMENT
        SHALL BECOME EFFECTIVE ON SUCH DATE AS THE COMMISSION, ACTING
        PURSUANT TO SAID SECTION 8(A), MAY DETERMINE.








        PROSPECTUS

                                  96,029 Shares
PAGE
<PAGE>





                         THERMO INSTRUMENT SYSTEMS INC.

                                  Common Stock

             This Prospectus relates to 96,029 shares (the "Shares") of
        Common Stock, par value $.10 per share (the "Common Stock"), of
        Thermo Instrument Systems Inc. (the "Company").  The Shares may
        be offered by the Thermo Electron Corporation Employees Stock
        Ownership Plan and Trust (the "Selling Shareholder" or the
        "Plan"), a profit sharing plan qualified under Section 401(a) of
        the Internal Revenue Code of 1986, as amended (the "Code"), from
        time to time in transactions on the American Stock Exchange, in
        negotiated transactions, through the writing of options on the
        Shares, or a combination of such methods of sale, at fixed prices
        that may be changed, at market prices prevailing at the time of
        sale, at prices related to such prevailing market prices or at
        negotiated prices.  The Selling Shareholder may effect such
        transactions by selling the Shares to or through broker-dealers,
        and such broker-dealers may receive compensation in the form of
        discounts, concessions or commissions from the Selling
        Shareholder and/or the purchasers of the Shares for whom such
        broker-dealers may act as agent or to whom they sell as
        principal, or both (which compensation to a particular
        broker-dealer might be in excess of customary commissions).
        Alternatively, the Selling Shareholder may distribute some or all
        of the Shares to participants in the Plan who elect to receive
        distributions in kind upon the termination of the Plan.  Shares
        not so sold or distributed may be transferred to a successor plan
        qualified under Section 401(a) of the Code.  The Selling
        Shareholder and any broker-dealer who acts in connection with the
        sales of Shares hereunder may be deemed to be "underwriters" as
        that term is defined in the Securities Act of 1933, as amended
        (the "Securities Act"), and any commissions received by them and
        profit on any resale of the Shares as principal might be deemed
        to be underwriting discounts and commissions under the Securities
        Act.  The Shares were originally acquired by the Selling
        Shareholder in open market transactions or in the form of
        contributions from the Company or from Thermo Electron
        Corporation, which owns a majority of the Company's outstanding
        capital stock ("Thermo Electron").  See "Selling Shareholder."

                                  _____________


          THESE SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE
           SECURITIES AND EXCHANGE COMMISSION OR ANY STATE SECURITIES
           COMMISSION NOR HAS THE SECURITIES AND EXCHANGE COMMISSION 
            OR ANY STATE SECURITIES COMMISSION PASSED UPON THE ACCU-
               RACY OR ADEQUACY OF THIS PROSPECTUS. ANY REPRESEN-
                  TATION TO THE CONTRARY IS A CRIMINAL OFFENSE.


                                  -------------
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<PAGE>





             None of the proceeds from the sale of the Shares by the
        Selling Shareholder will be received by the Company.  The Company
        has agreed to bear all expenses (other than underwriting
        discounts and selling commissions, and fees and expenses of
        counsel or other advisers to the Selling Shareholder) in
        connection with the registration and sale of the Shares being
        registered hereby.  The Company has agreed to indemnify the
        Selling Shareholder against certain liabilities, including
        liabilities under the Securities Act as underwriters or
        otherwise.


        ________, 1996 

                                  _____________


             No dealer, salesman or other person has been authorized to
        give any information or to make any representations other than
        those contained or incorporated by reference in this Prospectus
        regarding the Company or the offering made by this Prospectus,
        and, if given or made, such information or representations must
        not be relied upon as having been authorized by the Company or by
        any other person.  All information contained in this Prospectus
        is as of the date of this Prospectus.  Neither the delivery of
        this Prospectus nor any sale or distribution and resale made
        hereunder shall, under any circumstances, create any implication
        that there has been no change in the affairs of the Company since
        the date hereof.  This Prospectus does not constitute an offer to
        sell or a solicitation of any offer to buy any security other
        than the securities covered by this Prospectus, nor does it
        constitute an offer to or solicitation of any person in any
        jurisdiction in which such offer or solicitation may not be
        lawfully made.

                                  _____________


                              AVAILABLE INFORMATION

             The Company is subject to the informational requirements of
        the Securities Exchange Act of 1934, as amended (the "Exchange
        Act"), and in accordance therewith files reports, proxy
        statements and other information with the Securities and Exchange
        Commission (the "Commission").  Such reports, proxy statements
        and other information can be inspected and copied at the public
        reference facilities maintained by the Commission at 450 Fifth
        Street, N.W., Washington, D.C. 20549, and at the following
        Regional Offices of the Commission:  500 West Madison Street,
        Suite 1400, Chicago, Illinois 60661, and 7 World Trade Center,
        Suite 1300, New York, New York 10048.  Copies of such material
        can also be obtained from the Public Reference Section of the
        Commission at 450 Fifth Street, N.W., Washington, D.C. 20549 at
        prescribed rates.  The Common Stock of the Company is listed on

                                        2
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        the American Stock Exchange, and the reports, proxy statements
        and other information filed by the Company with the Commission
        can be inspected at the offices of the American Stock Exchange,
        86 Trinity Place, New York, New York  10006.

             This Prospectus, which constitutes part of a Registration
        Statement filed by the Company with the Commission under the
        Securities Act, omits certain of the information contained in the
        Registration Statement.  Reference is hereby made to the
        Registration Statement and to the exhibits relating thereto for
        further information with respect to the Company and the Shares
        offered hereby.  Statements contained herein concerning
        provisions of documents are necessarily summaries of such
        documents, and each statement is qualified in its entirety by
        reference to the applicable document filed with the Commission.

             The Company undertakes to provide without charge to each
        person to whom a copy of this Prospectus has been delivered, on
        the written or oral request of such person, a copy of any or all
        of the documents that have been or may be incorporated in this
        Prospectus by reference, other than exhibits to such documents
        (unless such exhibits are specifically incorporated by reference
        therein).  Requests for such copies should be directed to:
        Sandra L. Lambert, Secretary, Thermo Instrument Systems Inc., 81
        Wyman Street, P. O. Box 9046, Waltham, Massachusetts 02254-9046
        (telephone number: (617) 622-1000).


                                   THE COMPANY

             The Company manufactures and markets instruments that employ
        a variety of advanced analytical techniques to determine the
        composition, structure, and physical properties of natural and
        synthetic substances.  The Company's instruments are used for
        environmental and nuclear monitoring, process control, as well as
        imaging, inspection, and measurement.

             The Company has adopted Thermo Electron's spinout strategy
        in an effort to more clearly focus its many analytical
        technologies on their more specific niche markets.  To date, the
        Company has completed initial public offerings of ThermoSpectra
        Corporation ("ThermoSpectra") and ThermoQuest Corporation
        ("ThermoQuest"), has privately offered equity in Thermo
        BioAnalysis Corporation ("Thermo BioAnalysis"), and has privately
        sold convertible debentures in both Thermo Optek Corporation
        ("Thermo Optek") and ThermoQuest.  The debentures issued by
        Thermo Optek are not convertible into common stock until after
        that company completes an initial public offering of common
        stock.

             ThermoSpectra manufactures and markets precision imaging,
        inspection, and measurement instruments based on high-speed data
        acquisition and digital processing technologies to provide
        industrial and research customers with integrated systems that

                                        3
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        address their specific needs.  ThermoSpectra's products include
        digital oscillographic recorders and data acquisition systems
        that continuously measure and monitor signals from various
        sensors; digital storage oscilloscopes that are capable of taking
        hundreds of millions of measurements per second of transient
        signals or short bursts of data; X-ray microanalyzers used as
        accessories to electron microscopes to provide elemental
        materials analysis as a supplement to the microscope's imaging
        capabilities; non-destructive X-ray inspection systems for
        process monitoring and quality control applications; and confocal
        laser scanning microscopes that use laser light to generate
        precise optical images primarily for life science applications.

             Thermo BioAnalysis develops, manufactures, and sells
        capillary electrophoresis systems, matrix-assisted laser
        desorption/ionization time-of-flight ("MALDI-TOF") mass
        spectrometers, and health physics instrumentation.  Capillary
        electrophoresis is a separation technique based on a combination
        of chromatographic and electroanalytical technologies and is
        particularly useful in biochemical, pharmaceutical, and
        environmental research.  MALDI-TOF mass spectrometers measure the
        weight of the components of a sample and identify inorganic
        chemical components and/or inorganic elements contained within
        the sample.  Thermo BioAnalysis' health physics division
        manufactures and sells radiation detection and counting
        instrumentation and sophisticated radiation monitoring systems to
        the nuclear industry throughout the world.  Through the February
        1996 acquisition of DLW, Thermo BioAnalysis develops,
        manufactures, and sells immunoassay products.  Immunoassay is an
        analytical method used for the qualitative and quantitative
        analysis of biological molecules.  Immunoassay products are
        widely used in pharmaceutical and biopharmaceutical research, as
        well as for clinical testing of patient samples.

             Thermo Optek is a leader in the development, manufacture,
        and marketing of products used for both elemental and molecular
        analysis. These products are based on several optical
        spectroscopy techniques, including atomic emission ("AE"), atomic
        absorption ("AA"), and Fourier transform infrared ("FT-IR") and
        FT-Raman technologies.  Thermo Optek's AE and AA spectrometers
        identify and measure trace quantities of metals and other
        elements in a wide variety of materials, including environmental
        samples (such as soil, water, and wastes), foods, drugs,
        cosmetics, and alloys.  Thermo Optek sells its products to a
        range of customers in manufacturing industries such as producers
        of aircraft, automobiles and trucks, computers, chemicals, food,
        pharmaceuticals, and primary metals; in service industries such
        as waste management companies and commercial testing
        laboratories; and to government and university laboratories.
        Thermo Optek is a leading manufacturer of sequential AE
        spectrometers, in which elements are analyzed one at a time, and
        simultaneous AE spectrometers, in which many elements can be
        measured at the same time. The principal type of AE spectrometer
        used for elemental analysis of liquids is the ICP mass

                                        4
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        spectrometer ("ICP"), which allows for simultaneous multi-element
        testing. Thermo Optek is a market and technology leader in ICP
        spectrometry and has developed the first ultratrace ICP
        spectrometer, the first ICP spectrometer to incorporate a solid
        state detector, and the first combined optical emission/mass
        spectrometer.  Thermo Optek produces AA spectrometers in single-,
        double- and four-channel models.  Thermo Optek is the only major
        producer of multichannel AA spectrometers, which provide several
        operational advantages over single-channel instruments, including
        speed of analysis, increased accuracy, reduced sample
        consumption, and analysis over an extended range of
        concentrations.

             Thermo Optek is a leading manufacturer of molecular analysis
        systems that use FT-IR and FT-Raman spectroscopic techniques.
        FT-IR and FT-Raman spectrometers are designed to nondestructively
        determine the chemical composition and physical properties of
        materials.  These instruments are used in many areas of chemical
        research, industrial quality control, and process monitoring, and
        for solving a wide variety of materials-analysis problems.
        Thermo Optek offers a variety of models ranging from newly
        introduced models designed for routine applications to highly
        advanced research-grade FT-IR spectrometers.

             ThermoQuest is a leading manufacturer of commercial mass
        spectrometers and has pioneered many of the significant
        developments and applications of mass spectrometry.
        ThermoQuest's mass spectrometry products identify and measure the
        components of a sample for organic chemical compounds or for
        inorganic compounds. These instruments are used primarily by
        pharmaceutical companies for drug research, testing, and quality
        control; by environmental laboratories for testing water, air,
        and soil samples for compliance with environmental regulations;
        by chemical companies for research and quality control; by
        manufacturers for testing in certain industrial applications,
        such as the manufacture of semiconductor components, and for
        quality control; by food and beverage companies for quality
        control and to test product contamination; and in forensic
        applications.  ThermoQuest provides both stand-alone mass
        spectrometers and combined systems that use its own
        chromatographs or those purchased from other companies.  These
        products span a range of sensitivity, specificity, separation
        technologies, data-handling capabilities, sizes, and prices.

             ThermoQuest also manufactures high performance liquid
        chromatographs, gas chromatographs, and related instruments and
        equipment used principally in the research and development and
        production monitoring of pharmaceuticals and chemicals, and for
        environmental monitoring.  These instruments separate the
        chemical components of substances for purposes of identification
        and measurement.  Gas chromatographs and liquid chromatographs
        are widely used in environmental and industrial laboratories as
        stand-alone instruments or in conjunction with mass
        spectrometers, where the gas or liquid chromatograph separates a

                                        5
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        sample into individual chemical components for the mass
        spectrometer to identify.  Applications include the
        identification of organic compounds, from pesticide residues on
        vegetables to chlorinated organics in drinking water.  In 1995,
        ThermoQuest introduced its GCQ(TM) and LCQ(TM) benchtop gas
        chromatography/mass spectrometry and liquid chromatography/mass
        spectrometry products. These systems are based on the Company's
        proprietary ion trap technology and are capable of multi-stage
        mass spectrometry.

             In other wholly owned businesses, the Company manufactures
        monitoring instruments for two principal markets: the detection
        and measurement of nuclear radiation, and the monitoring of air
        pollutants including toxic and combustible gases.

             The Company's nuclear radiation monitoring instruments
        detect and measure alpha, beta, gamma, neutron, and X-ray
        radiation emitted by natural sources and by radioactive materials
        used in nuclear power plants and certain governmental,
        industrial, and medical facilities.  The Company is a leading
        manufacturer of a broad range of stand-alone and portable
        instruments and computer-integrated instrument systems used to
        ensure the safety of personnel from exposure to nuclear
        radiation.  In addition, the Company is a major supplier of
        instruments and systems that are manufactured to European
        standards for personnel protection and environmental monitoring.
        The Company also manufactures industrial gauging and process
        control instruments used principally by manufacturers of flat
        sheet materials, including metals, plastics, rubber, paper, and
        fibers.

             The Company's air-monitoring instruments measure pollutants
        in ambient air and from stationary sources such as industrial
        smokestacks.  The principal pollutants measured are oxides of
        nitrogen, sulfur dioxide, carbon monoxide, ozone, and volatile
        organic compounds.  These instruments are used by utility and
        industrial customers to ensure compliance with environmental
        regulations, by government agencies to monitor air quality, and
        by research facilities.  The Occupational Safety and Health
        Administration's safety requirements for protecting workers from
        toxic or explosive atmospheres in confined spaces are addressed
        with the Company's detectors, instruments, and systems for
        sensing, monitoring, and warning of such dangers.  These
        worker-safety products are used in a wide range of applications,
        from large petrochemical plants, utilities, and industrial
        manufacturing facilities to commercial buildings.

             The 1995 acquisition of the Analytical Instrument Division
        of Analytical Technology, Inc. added to the Company's product
        offerings in several analytical areas, notably in ultraviolet
        visual spectrometry and thermogravimetric analysis ("TGA").
        Ultraviolet visual spectrometry instruments are based upon the
        selective absorbence of ultraviolet radiation by various
        substances.  An important use of ultraviolet instruments is the

                                        6
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        identification and determination of biologically active
        substances.  These instruments are often used by life science
        researchers, pharmaceutical companies, and environmental testing
        laboratories.  TGA systems are employed in the chemicals,
        plastics-polymers, and pharmaceutical industries for measuring
        changes in mass as a function of temperature.  Specific fields
        which have widely used TGA include studies involving the thermal
        stability of minerals, pyrolysis of coals and petroleums, and
        thermochemical reactions of ceramics and cements.

             In addition, the Company manufactures equipment that
        provides on-line, real-time analysis of elements in bulk raw
        materials, such as coal and cement.  These analyzers are used by
        utilities to determine the sulfur content of coal to ensure
        compliance with air quality standards and by the cement industry
        to test raw materials to assure product quality and uniformity.

             The Company also participates in the process monitoring,
        analysis, gauging, and control instruments markets, primarily for
        the oil, gas, and petrochemical industries.  The Company
        manufactures and markets a number of process monitoring,
        analysis, and control systems including: analog and digital
        recorders for continuous process industries; process and
        laboratory analytical instruments and monitors to detect lethal
        gases for the oil, gas, and petrochemical industries; supervisory
        control and data acquisition software for process monitoring and
        operator interface in a variety of industrial processes; and
        turnkey, integrated systems to control networks of distant oil
        and gas wells.

             The Company also manufactures and markets process gauges and
        noncontacting and nonintrusive process control instrumentation to
        measure liquid levels, density, weight, and flows for a variety
        of industries.  Application examples include measuring levels in
        a pharmaceutical reactor, determining the percentage by weight of
        solids contained in a mining slurry, or monitoring the flow of
        fluid into a wastewater treatment facility.  The Company's X-ray
        fluorescence instruments allow for the nondestructive analysis of
        inorganic elements.  Applications include alloy identification,
        on-line process monitoring and quality control, characterization
        of toxic metals in soil, and thickness and/or composition of
        semiconductor thin films. 

             The Company is a majority-owned, publicly traded subsidiary
        of Thermo Electron.  As of December 30, 1995, Thermo Electron
        owned 78,459,585 shares of the Common Stock of the Company,
        representing approximately 86% of such Common Stock outstanding.
        The Company's principal executive offices are located at 504
        Airport Road, Post Office Box 2108, Santa Fe, New Mexico
        87504-2108, and its telephone number is (505) 438-3171. 
                               SELLING SHAREHOLDER

             The following table sets forth the name of the Selling
        Shareholder, the number of shares of Common Stock owned by the

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        Selling Shareholder, the number of Shares that may be offered by
        the Selling Shareholder pursuant to this Prospectus, and the
        number of Shares the Selling Shareholder will own after
        completion of the offering, assuming all of the Shares being
        offered hereby are sold. 

                                    Shares of
                                      Common                   Shares
                                      Stock                     Owned
                                      Owned                     After
                                     Prior to     Shares     Completion
            Selling Shareholder        the         Being       of the
            -------------------
                                     Offering     Offered     Offering
                                     --------     -------     --------


             Thermo Electron
             Corporation Employees    96,029      96,029          0
             Stock Ownership Plan
             and Trust

        __________________

             (1)  Certain officers and directors of the Company and/or of
                  Thermo Electron are trustees of the Selling
                  Shareholder.

             The Shares are being registered to permit the sale of the
        Shares by the Selling Shareholder to the public.  All of the
        Shares being offered by the Selling Shareholder were originally
        acquired by the Selling Shareholder in open market transactions
        or in the form of contributions from the Company or from Thermo
        Electron.  The Selling Shareholder is selling the Shares in
        connection with the liquidation and termination of the Plan in
        order to repay loans made to the Plan by Thermo Electron and to
        distribute the remaining proceeds to beneficiaries of the Plan.
        Thermo Electron has agreed to bear all expenses (other than
        underwriting discounts, selling commissions, and fees and
        expenses of counsel and other advisors to the Selling
        Shareholder) in connection with the registration and sale of the
        Shares being offered by the Selling Shareholder.  See "Sale of
        Shares."  The Company has agreed to prepare and file such
        amendments and supplements to the Registration Statement of which
        this Prospectus forms a part as may be necessary to keep the
        Registration Statement effective until all the Shares registered
        thereunder have been sold pursuant thereto or until, by reason of
        Rule 144(k) of the Commission under the Securities Act or any
        other rule of similar effect, the Shares are no longer required
        to be registered for the sale thereof by the Selling Shareholder.


                                 SALE OF SHARES

             The Company has been advised that the Selling Shareholder
        may sell Shares from time to time in transactions on the American

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        Stock Exchange, in negotiated transactions, through the writing
        of options on the Shares, or a combination of such methods of
        sale, at fixed prices which may be changed, at market prices
        prevailing at the time of sale, at prices related to such
        prevailing market price or at negotiated prices.  The Selling
        Shareholder may effect such transactions by selling the Shares to
        or through broker-dealers, and such broker-dealers may receive
        compensation in the form of discounts, concessions or commissions
        from the Selling Shareholder and/or the purchasers of the Shares
        for whom such broker-dealers may act as agent or to whom they
        sell as principal, or both (which compensation to a particular
        broker-dealer might be in excess of customary commissions).
        Alternatively, the Selling Shareholder may distribute some or all
        of the Shares to participants in the Plan who elect to receive
        distributions in kind upon the termination of the Plan.  Shares
        not so sold or distributed may be transferred to a successor plan
        qualified under Section 401(a) of the Code.  

             The Selling Shareholder and any broker-dealers who act in
        connection with the sale of Shares hereunder may be deemed to be
        "underwriters" as that term is defined in the Securities Act, and
        any commissions received by them and profit on any resale of the
        Shares as principal might be deemed to be underwriting discounts
        and commissions under the Securities Act.  The Company has agreed
        to indemnify the Selling Shareholder against certain liabilities,
        including liabilities under the Securities Act as underwriters or
        otherwise.


                 INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE

             The following documents previously filed with the Commission
        are incorporated in this Prospectus by reference:

             (1)  The Company's Annual Report on Form 10-K for the year
                  ended December 30, 1995.

             (2)  The description of the Common Stock which is contained
                  in the Company's Registration Statement on Form 8-A,
                  filed under the Exchange Act, as amended.

                  All reports or proxy statements filed by the Company
        pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Exchange
        Act subsequent to the date of this Prospectus and prior to the
        termination of the offering made hereby shall be deemed to be
        incorporated by reference in this Prospectus and to be a part
        hereof from the respective dates of filing such documents.  Any
        statement contained in a document incorporated or deemed to be
        incorporated by reference herein shall be deemed to be modified
        or superseded for purposes of this Prospectus to the extent that
        a statement contained herein modifies, supersedes or replaces
        that statement.  Any statement so modified or superseded shall
        not be deemed, except as so modified or superseded, to constitute
        a part of this Prospectus.

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                                  LEGAL MATTERS

             The validity of the Common Stock offered hereby has been
        passed upon by Seth H. Hoogasian, Esq., General Counsel of the
        Company.  Mr. Hoogasian owns or has the right to acquire,
        pursuant to the exercise of stock options, shares of the Common
        Stock of the Company and of certain of the Company's
        subsidiaries, the fair market value of which exceeds $50,000.


                                     EXPERTS

             The financial statements and schedule of the Company for the
        year ended April 1, 1995, incorporated in this Prospectus by
        reference to the Company's Annual Report on Form 10-K, as
        amended, for the year ended April 1, 1995 have been audited by
        Arthur Andersen LLP, independent public accountants, to the
        extent and for the periods as indicated in their reports with
        respect thereto, and are incorporated herein in reliance upon the
        authority of said firm as experts in giving said reports.  

































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                                     PART II

                     INFORMATION NOT REQUIRED IN PROSPECTUS

             Item 14.  Other Expenses of Issuance and Distribution.

             The expenses incurred by the Company in connection with the
        issuance and distribution of the securities being registered are
        as follows.  All amounts are estimated except the Securities and
        Exchange Commission registration fee.                            
                                
                                                              Amount
                                                              ------

             Registration fee - Securities and Exchange
             Commission ...................................$      979
             Legal fees and expenses ......................     1,000
             Accounting fees and expenses .................     2,000

             Miscellaneous ................................     1,000
                  Total ...................................$    4,979


        Item 15.  Indemnification of Directors and Officers. 

             The Delaware General Corporation Law and the Company's
        Certificate of Incorporation and By-Laws limit the monetary
        liability of directors to the Company and to its stockholders and
        provide for indemnification of the Company's officers and
        directors for liabilities and expenses that they may incur in
        such capacities. In general, officers and directors are
        indemnified with respect to actions taken in good faith in a
        manner reasonably believed to be in, or not opposed to, the best
        interests of the Company, and with respect to any criminal action
        or proceeding, actions that the indemnitee had no reasonable
        cause to believe were unlawful. The Company also has
        indemnification agreements with its directors and officers that
        provide for the maximum indemnification allowed by law.  

             Thermo Electron Corporation has an insurance policy which
        insures the directors and officers of Thermo Electron and its
        subsidiaries, including the Company, against certain liabilities
        which might be incurred in connection with the performance of
        their duties.


             Item 16.  Exhibits and Financial Statement Schedules.

             See the Exhibit Index included immediately preceding the
        exhibits to this Registration Statement.






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             Item 17.  Undertakings.

             (a)  The undersigned Registrant hereby undertakes:

                   (1) To file, during any period in which offers or
                       sales are being made, a post-effective amendment
                       to this registration statement:

                       (i)  To include any prospectus required by Section
                            10(a)(3) of the Securities Act of 1933;

                       (ii) To reflect in the prospectus any facts or
                            events arising after the effective date of
                            the registration statement (or the most
                            recent post-effective amendment thereof)
                            which, individually or in the aggregate,
                            represent a fundamental change in the
                            information set forth in the registration
                            statement.  Notwithstanding the foregoing,
                            any increase or decrease in volume of
                            securities offered (if the total dollar value
                            of securities offered would not exceed that
                            which was registered) and any deviation from
                            the low or high end of the estimated maximum
                            offering range may be reflected in the form
                            of prospectus filed with the Commission
                            pursuant to Rule 424(b) if, in the aggregate,
                            the changes in volume and price represent no
                            more than 20 percent change in the maximum
                            aggregate offering price set forth in the
                            "Calculation of Registration Fee" table in
                            the effective registration statement;

                       (iii)To include any material information with
                            respect to the plan of distribution not
                            previously disclosed in the registration
                            statement or any material change to such
                            information in the registration statement.

                            Provided, however, that paragraphs (a)(1)(i)
                       and (a)(1)(ii) do not apply if the registration
                       statement is on Form S-3 or Form S-8, and the
                       information required to be included in a
                       post-effective amendment by those paragraphs is
                       contained in periodic reports filed by the
                       Registrant pursuant to Section 13 or Section 15(d)
                       of the Securities Exchange Act of 1934 that are
                       incorporated by reference in the registration
                       statement.

                  (2)  That, for the purpose of determining any liability
                       under the Securities Act of 1933, each such
                       post-effective amendment shall be deemed to be a
                       new registration statement relating to the

                                       12
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                       securities offered therein, and the offering of
                       such securities at that time shall be deemed to be
                       the initial bona fide offering thereof.

                  (3)  To remove from registration by means of a
                       post-effective amendment any of the securities
                       being registered which remain unsold at the
                       termination of the offering.

             (b)  The undersigned Registrant hereby undertakes that, for
        purposes of determining any liability under the Securities Act of
        1933, each filing of the Registrant's annual report pursuant to
        Section 13(a) or Section 15(d) of the Securities Exchange Act of
        1934 that is incorporated by reference in this registration
        statement shall be deemed to be a new registration statement
        relating to the securities offered herein, and the offering of
        such securities at that time shall be deemed to be the initial
        bona fide offering thereof.

             (c)  Insofar as indemnification for liabilities arising
        under the Securities Act of 1933 may be permitted to directors,
        officers and controlling persons of the Registrant pursuant to
        the foregoing provisions, or otherwise, the Registrant has been
        advised that in the opinion of the Securities and Exchange
        Commission such indemnification is against public policy as
        expressed in the Act and is, therefore, unenforceable.  In the
        event that a claim for indemnification against such liabilities
        (other than the payment by the Registrant of expenses incurred or
        paid by a director, officer or controlling person of the
        Registrant in the successful defense of any action, suit or
        proceeding) is asserted by such director, officer or controlling
        person in connection with the securities being registered, the
        Registrant will, unless in the opinion of its counsel the matter
        has been settled by controlling precedent, submit to a court of
        appropriate jurisdiction the question whether such
        indemnification by it is against public policy as expressed in
        the Act and will be governed by the final adjudication of such
        issue.

















                                       13
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<PAGE>





                                   SIGNATURES

             Pursuant to the requirements of the Securities Act of 1933,
        the Registrant hereby certifies that it has reasonable grounds to
        believe that it meets all of the requirements for filing on Form
        S-3 and has duly caused this Registration Statement to be signed
        on its behalf by the undersigned, thereunto duly authorized, in
        the City of Waltham, Commonwealth of Massachusetts, on this 29th
        day of March, 1996.

                                      THERMO INSTRUMENT SYSTEMS INC.

                                      By:  Arvin H. Smith
                                           -------------------------
                                           Arvin H. Smith, President 
                                           and Chief Executive Officer


             KNOW ALL MEN BY THESE PRESENTS that each individual whose
        signature appears below constitutes and appoints John N.
        Hatsopoulos, Paul F. Kelleher, Seth H. Hoogasian, Sandra L.
        Lambert and Jonathan W. Painter, and each of them, as his true
        and lawful attorneys-in-fact and agents for the undersigned, with
        full power of substitution, for and in the name, place and stead
        of the undersigned, to sign and file with the Securities and
        Exchange Commission under the Securities Act of 1933 any and all
        amendments and exhibits to this Registration Statement and any
        and all applications and other documents to be filed with the
        Securities and Exchange Commission pertaining to the registration
        of the securities covered hereby, with full power and authority
        to do and perform any and all acts and things whatsoever
        requisite and necessary or desirable.

             Pursuant to the requirements of the Securities Act of 1933,
        this Registration Statement has been signed by the following
        persons in the capacities and on the dates indicated.

               Signature        Title
               ---------        -----
                                Title                      Date
- -                                                          ----
                                          



                               President, Chief
                               Executive 
        Arvin H. Smith         Officer and Director    March 29, 1996
        Arvin H. Smith

                               Vice President, Chief
                               Financial Officer and 
        John N. Hatsopoulos    Director                March 29, 1996

        John N. Hatsopoulos
                               Chief Accounting
        Paul F. Kelleher       Officer                 March 29, 1996
        Paul F. Kelleher


                                       14
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<PAGE>





               Signature        Title
               ---------        -----
                                                           Date
       ----                                                ----




        Marshall J. Armstrong  Director                March 29, 1996
        Marshall J. Armstrong



        Frank Borman           Director                March 29, 1996
        Frank Borman



        George N. Hatsopoulos  Chairman of the Board   March 29, 1996
        George N. Hatsopoulos



        Elias P. Gyftopoulos   Director                March 29, 1996
        Elias P. Gyftopoulos



        Robert C. Howard       Director                March 29, 1996

        Robert C. Howard


        Frank Jungers          Director                March 29, 1996

        Frank Jungers


        Robert A. McCabe       Director                March 29, 1996

        Robert A. McCabe


        Polyvios C. Vintiadis  Director                March 29, 1996

        Polyvios C. Vintiadis












                                       15
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<PAGE>





                                  EXHIBIT INDEX


        Exhibit                                                        
        Sequential
        Number         Description of Exhibit                   Page No.
        ------         ----------------------                   --------

               
            5        Opinion of Seth H. Hoogasian, Esq.          

             23(a)    Consent of Arthur Andersen LLP 

               (b)    Consent of Seth H. Hoogasian, Esq.
                      (contained in Exhibit 5)

             24       Power of Attorney (See Signature Page)















































                                                                EXHIBIT 5



                         THERMO INSTRUMENT SYSTEMS INC.
                                504 Airport Road
                        Santa Fe, New Mexico  87504-2108

                                 March 29, 1996


        Thermo Instrument Systems Inc.
        504 Airport Road
        Santa Fe, New Mexico  87504-2108

             Re:  Registration Statement on Form S-3

        Dear Sirs:

             I am General Counsel to Thermo Instrument Systems Inc., a
        Delaware corporation (the "Company"), and have acted as counsel
        in connection with the registration under the Securities Act of
        1933, as amended, on Form S-3 (the "Registration Statement"), of
        96,029 shares of the Company's Common Stock, $.10 par value per
        share (the "Shares"), which may from time to time be sold by a
        shareholder of the Company.

             I or a member of my staff  have reviewed the corporate
        proceedings taken by the Company with respect to the
        authorization of the issuance of the Shares.  I or a member of my
        staff have also examined and relied upon originals or copies,
        certified or otherwise authenticated to my satisfaction, of all
        corporate records, documents, agreements or other instruments of
        the Company, and have made investigations of law and have
        discussed with the Company's representatives questions of fact
        that I or a member of my staff have deemed necessary or
        appropriate.

             Based upon and subject to the foregoing, I am of the opinion
        that the Shares have been duly authorized by the Company and are
        validly issued, fully paid and non-assessable.

             I hereby consent to the filing of this opinion as Exhibit 5
        to the Registration Statement, including any amendments thereto,
        and to the use of my name under the caption "Legal Matters" in
        the prospectus constituting a part thereof.       

                                           Sincerely,



                                           Seth H. Hoogasian
                                           General Counsel








                                                            EXHIBIT 23(a)


                    CONSENT OF INDEPENDENT PUBLIC ACCOUNTANTS



        As independent public accountants, we hereby consent to the
        incorporation by reference in this registration statement of our
        reports dated February 12, 1996 (except with respect to the
        matters discussed in Note 15 as to which the date is March 1,
        1996) included in Thermo Instrument Systems Inc.'s Form 10-K for
        the year ended December 30, 1995 and to all references to our
        Firm included in this registration statement.



        ARTHUR ANDERSEN LLP

        Boston, Massachusetts  



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