THERMO INSTRUMENT SYSTEMS INC
S-3/A, 1997-03-27
MEASURING & CONTROLLING DEVICES, NEC
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 As filed with the Securities and Exchange Commission on March 27, 1997
                                              Registration No. 333-17707
                                                                       

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C.  20549

                                 Amendment No. 1
                                       to
                                    FORM S-3
                             Registration Statement
                                      UNDER
                           THE SECURITIES ACT OF 1933

                         THERMO INSTRUMENT SYSTEMS INC.
             (Exact name of registrant as specified in its charter)

                               ------------------

           Delaware                                        04-2925809

        (State or other jurisdiction of         (I.R.S. Employer
         incorporation or organization)           Identification No.)
      

                             1275 Hammerwood Avenue
                               Sunnyvale, CA 94089
                                 (617) 622-1000
          (Address, including zip code, and telephone number, including
             area code, of registrant's principal executive offices)

                          Sandra L. Lambert, Secretary
                         Thermo Instrument Systems Inc.
                                 81 Wyman Street
                                  P.O. Box 9046
                             Waltham, MA  02254-9046
                                 (617) 622-1000
            (Name, address, including zip code, and telephone number,
                   including area code, of agent for service)


                                   Copies to:
        Seth H. Hoogasian, Esquire          Edwin L. Miller, Jr., Esquire
           General Counsel                  Testa, Hurwitz & Thibeault
        Thermo Instrument Systems Inc.             High Street Tower
             81 Wyman Street                     125 High Street
             P.O. Box 9046                  Boston, Massachusetts 02109
        Waltham, Massachusetts 02254-9046


                              ---------------------
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<PAGE>




             Approximate date of commencement of proposed sale to the
        public:  As soon as practicable after the Registration Statement
        has become effective.
PAGE
<PAGE>





             If the only securities being registered on this form are
        being offered pursuant to dividend or interest reinvestment
        plans, please check the following box.   [   ]

             If any of the securities being registered on this form are
        to be offered on a delayed or continuous
        basis pursuant to Rule 415 under the Securities Act of 1933,
        other than securities offered only in connection with dividend or
        interest reinvestment plans, check the following box.   [  x ]

             If this Form is filed to register additional securities for
        an offering pursuant to Rule 462(b) under the Securities Act,
        please check the following box and list the Securities Act
        registration statement number of the earlier effective
        registration statement for the same offering. [    ]

             If this Form is a post-effective amendment filed pursuant to
        Rule 462(b) under the Securities Act, check the following box and
        list the Securities Act registration statement number of the
        earlier effective registration statement for the same offering.
        [   ]

             If delivery of the prospectus is expected to be made
        pursuant to Rule 434, please check the following box. [   ]

             The Registrant hereby amends this Registration Statement on
        such date or dates as may be necessary to delay its effective
        date until the Registrant shall file a further amendment which
        specifically states that this Registration Statement shall
        thereafter become effective in accordance with Section 8(a) of
        the Securities Act of 1933 or until this Registration Statement
        shall become effective on such date as the Commission, acting
        pursuant to said Section 8(a), may determine.

PAGE
<PAGE>




        P R O S P E C T U S      2,174,948 SHARES

                         THERMO INSTRUMENT SYSTEMS INC.

                                  Common Stock

                            PAR VALUE $.10 Per Share
                              ____________________

             This Prospectus relates to the resale of  2,174,948 shares
        (the "Shares") of common stock, par value $.10 per share (the
        "Common Stock"), of Thermo Instrument Systems Inc. (the
        "Company") issuable upon conversion of $93,675,000 principal
        amount of the Company's outstanding 4 1/2% Senior Convertible
        Debentures due 2003 (the "Debentures").  The Debentures are
        convertible, at the option of the holder (a "Selling
        Shareholder"), at a conversion price of $43.07 per share, subject
        to adjustment for certain events.  The Shares may be offered from
        time to time in transactions on the American Stock Exchange, in
        negotiated transactions, through the writing of options on the
        Shares, or a combination of such methods of sale, at fixed prices
        that may be changed, at market prices prevailing at the time of
        sale, at prices related to such prevailing market prices or at
        negotiated prices.  Such transactions may be effected by the sale
        of  the Shares to or through broker-dealers, and such
        broker-dealers may receive compensation in the form of discounts,
        concessions or commissions from the sellers and/or the purchasers
        of the Shares for whom such broker-dealers may act as agent or to
        whom they sell as principal, or both (which compensation to a
        particular broker-dealer might be in excess of customary
        commissions).  The sellers of the Shares and any broker-dealer
        who acts in connection with the sale of Shares hereunder may be
        deemed to be "underwriters" as that term is defined in the
        Securities Act of 1933, as amended (the "Securities Act"), and
        any commission received by them and profit on any resale of the
        Shares as principal might be deemed to be underwriting discounts
        and commissions under the Securities Act.

             None of the proceeds from the sale of the Shares will be
        received by the Company.  The Company has agreed to bear all
        expenses (other than underwriting discounts and selling
        commissions, and fees and expenses of counsel or other advisors
        to the Selling Shareholders) in connection with the registration
        and sale of the Shares being registered hereby.  The Company has
        agreed to indemnify the Selling Shareholders against certain
        liabilities, including liabilities under the Securities Act as
        underwriter or otherwise.


                             ----------------------

             THESE SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY
        THE SECURITIES AND EXCHANGE COMMISSION OR ANY STATE SECURITIES
        COMMISSION NOR HAS THE SECURITIES AND EXCHANGE COMMISSION OR ANY
        STATE SECURITIES COMMISSION PASSED UPON THE ACCURACY OR ADEQUACY
        OF THIS PROSPECTUS.  ANY REPRESENTATION TO THE CONTRARY IS A
        CRIMINAL OFFENSE.
                                        2
PAGE
<PAGE>




                             ______________________

             No dealer, salesman or other person has been authorized to
        give any information or to make any representations other than
        those contained or incorporated by reference in this Prospectus
        regarding the Company or the offering made by this Prospectus,
        and, if given or made, such information or representations must
        not be relied upon as having been authorized by the Company or by
        any other person.  All information contained in this Prospectus
        is as of the date of this Prospectus.  Neither the delivery of
        this Prospectus nor any sale or distribution and resale made
        hereunder shall, under any circumstances, create any implication
        that there has been no change in the affairs of the Company since
        the date hereof.  This Prospectus does not constitute an offer to
        sell or a solicitation of any offer to buy any security other
        than the securities covered by this Prospectus, nor does it
        constitute an offer to or solicitation of any offer to buy any
        security other than the securities covered by this Prospectus,
        nor does it constitute an offer to or solicitation of any person
        in any jurisdiction in which such offer or solicitation may not
        be lawfully made.

                          ____________________________

           
        March 27, 1997
            






























                                        3
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<PAGE>




                              AVAILABLE INFORMATION

             The Company is subject to the informational requirements of
        the Securities Exchange Act of 1934, as amended (the "Exchange
        Act"), and in accordance therewith files reports, proxy
        statements and other information with the Securities and Exchange
        Commission (the "Commission").  Reports, proxy statements and
        other information filed by the Company with the Commission can be
        inspected and copied at the public reference facilities
        maintained by the Commission at Room 1024, Judiciary Plaza, 450
        Fifth Street, N.W., Washington, D.C. 20549 or at its regional
        offices located at 500 West Madison Street, Chicago, Illinois
        60661, and Seven World Trade Center, 13th Floor,  New York, New
        York 10048.  Copies of such material can be obtained from the
        Public Reference Section of the Commission at 450 Fifth Street,
        N.W., Washington, D.C. 20549 at prescribed rates.  The Commission
        also maintains a Web site that contains reports, proxy and
        information statements and other information regarding
        registrants that file electronically with the Commission,
        including the Company.  The address of such site is
        http://www.sec.gov.  The Common Stock of the Company is listed on
        the American Stock Exchange (the "AMEX"), and the reports, proxy
        statements and other information filed by the Company with the
        Commission can be inspected at the office of the AMEX, 86 Trinity
        Place, New York, New York 10006.

             This Prospectus, which constitutes part of a registration
        statement (herein, together with all exhibits thereto, referred
        to as the "Registration Statement") filed by the Company with the
        Commission under the Securities Act of 1933 (the "Securities
        Act"), omits certain of the information contained in the
        Registration Statement. Reference is hereby made to the
        Registration Statement for further information with respect to
        the Company and the securities offered hereby.

             The Company undertakes to provide without charge to each
        person to whom a copy of this Prospectus has been delivered, on
        the written or oral request of such person, a copy of any or all
        of the documents that have been or may be incorporated in this
        Prospectus by reference, other than exhibits to such documents.
        Requests for such copies should be directed to:  Sandra L.
        Lambert, Secretary, Thermo Electron Corporation, 81 Wyman Street,
        P.O. Box 9046, Waltham, Massachusetts 02254-9046 (telephone
        number: (617-622-1000).

                                TABLE OF CONTENTS

        Available Information  ...................................... 2

        The Company  ................................................ 3
        Selling Shareholders  ....................................... 3
        Incorporation of Documents by Reference  .................... 4

        Legal Opinion  .............................................. 4
        Experts  .................................................... 4


                                        4
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<PAGE>






                                   THE COMPANY
           

             The Company is a worldwide leader in the development,
        manufacture, and marketing of analytical instruments used to
        identify complex chemical compounds, toxic metals, and other
        elements in a broad range of liquids and solids, as well as
        instruments used to monitor radioactivity and air pollution, and
        to control, image, inspect, and measure various industrial
        processes and life sciences phenomena.  The Company has adopted a
        strategy of spinning out certain of its businesses into separate
        subsidiaries and having these subsidiaries sell a minority
        interest to outside investors.  The Company believes that this
        strategy provides additional motivation and incentives for the
        management of the subsidiary through the establishment of
        subsidiary-level stock option incentive programs, as well as
        capital to support the subsidiaries.

             The Company historically has expanded both through the
        acquisition of companies and product lines and through internal
        development of new products and technologies.  During the past
        several years the Company has completed a number of significant
        acquisitions that have provided additional technologies,
        specialized manufacturing or product development expertise, and
        broader capabilities in marketing and distribution.  These
        acquisitions include a substantial portion of the businesses
        comprising the Scientific Instruments Division of Fisons plc in
        March 1996 for approximately $189 million and the assumption of
        approximately $47 million of indebtedness, the Analytical
        Instruments Division of Analytical Technology Inc. in December
        1995 for approximately $43 million and the DYNEX Technologies
        (formerly Dynatech Laboratories Worldwide) division of Dynatech
        Corporation in February 1996 for approximately $43 million.

             On March 12, 1997, the Company declared unconditional in all
        respects its cash tender offer for all outstanding shares of Life
        Sciences International PLC (Life Sciences) for 135 British pence
        per share (approximately $2.16 per share).  As of that date, the
        Company had received acceptances representing approximately 91%
        of the Life Sciences shares outstanding, and the Company owned an
        additional 3% of the outstanding Life Sciences shares.  There are
        approximately 175 million Life Sciences shares outstanding.  The
        Company has established March 26, 1997, as the date for payment
        for all shares as to which acceptance has been received.  In
        addition, The Company expects to repay approximately $72 million
        of Life Sciences' debt, net of acquired cash expected to be used.
        Life Sciences, a London Stock Exchange-listed company,
        manufactures laboratory science equipment, appliances,
        instruments, consumables, and reagents for the research,
        clinical, and industrial markets.

             The Company was incorporated in Delaware in May 1986 as a
        wholly owned subsidiary of Thermo Electron Corporation ("Thermo
        Electron") to succeed the instruments businesses that were
        previously conducted by several Thermo Electron subsidiaries.  As
                                        5
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<PAGE>




        of December 28, 1996, Thermo Electron owned 82% of the Company's
        outstanding Common  Stock.  Thermo Electron intends, for the
        foreseeable future, to maintain at least 80% ownership of the
        Company so that it may continue to file consolidated U.S. federal
        and certain state income tax returns with the Company.  The
        Company's principal executive offices are located at 1275
        Hammerwood Avenue, Sunnyvale, California 94089, and its telephone
        number is 617-622-1000.

            

                              SELLING SHAREHOLDERS

             The Selling Shareholders currently hold Debentures
        convertible into the Shares which are the subject of this
        Prospectus.  It is unknown if, when or in what amounts a Selling
        Shareholder may offer Shares for sale and the names of the
        Selling Shareholders who may sell the Shares.  There is no
        assurance that the Selling Shareholders will sell any or all of
        the Shares offered hereby.

             Because the Selling Shareholders may offer all or some of
        the Shares pursuant to the offering contemplated by this
        Prospectus, and because there are currently no agreements,
        arrangements or understandings with respect to the sale of any of
        the Shares that will be held by the Selling Shareholders after
        completion of this offering, no estimate can be given as to the
        principal amount of the Shares that will be held by the Selling
        Shareholders after completion of this offering.

             Other than as a result of the ownership of the Debentures,
        to the best of the Company's knowledge, none of the Selling
        Shareholders had any material relationship with the Company
        within the three year period ending on the date of this
        Prospectus.


                     INCORPORATION OF DOCUMENTS BY REFERENCE


           
             The following documents previously filed with the Commission
        are incorporated in this Prospectus by reference:

             (1)  The Company's Annual Report on Form 10-K for the fiscal
                  year ended December 28, 1996.

             (2)  The description of the Company's Common Stock contained
                  in the Company's Registration Statement on Form 8-A, as
                  amended.
            

             All reports and other documents subsequently filed by the
        Company pursuant to Sections 13(a), 13(c), 14 and 15(d) of the
        Exchange Act, prior to the termination of this offering shall be
        deemed to be incorporated by reference herein and to be part
        hereof from the date of the filing of such reports and documents.
                                        6
PAGE
<PAGE>





             Statements in documents incorporated by reference herein
        shall be deemed modified by statements herein.  Statements so
        modified shall constitute part of this Prospectus only as so
        modified.

                                  LEGAL OPINION

             Certain legal matters relating to the Shares  have been
        passed upon for the Company by Seth H. Hoogasian, General Counsel
        of  the Company.  Mr. Hoogasian owns or has the right to acquire
        16,737 shares of Common Stock, 20,000 shares of common stock of
        the Company's subsidiaries and 259,477 shares of the common stock
        of Thermo Electron and its other subsidiaries.

                                     EXPERTS

             The financial statements and schedules of the Company for
        the year ended December 28, 1996, incorporated in this
        Registration Statement by reference to the Company's Annual
        Report on Form 10-K for the year ended December 28, 1996 have
        been audited by Arthur Andersen LLP, independent public
        accountants, to the extent and for the periods as indicated in
        their reports with respect thereto, and are incorporated herein
        in reliance upon the authority of said firm as experts in giving
        said reports.































                                        7
PAGE
<PAGE>





                                     PART II

                     INFORMATION NOT REQUIRED IN PROSPECTUS

        Item 14.  Other Expenses of Issuance and Distribution.

             The expenses (other than the underwriting discount) incurred
        by the Company in connection with the issuance and distribution
        of the securities being registered (including the securities
        which may be issued pursuant to an over-allotment option) are as
        follows:

                                                               Amount*
                                                               -------
        Securities and Exchange Commission Registration Fee  $  22,204

        American Stock Exchange listing fee  ................  17,500
        Legal fees and expenses  ............................   5,000
        Accounting fees and expenses  .......................   5,000

        Miscellaneous  ......................................     296
             Total  .........................................$ 50,000

        _______________
             * All amounts are estimated except the Securities and
             Exchange Commission fee and 
                        the American Stock Exchange listing fee.


        Item 15.  Indemnification of Directors and Officers.

             The Delaware General Corporation Law and the Company's
        Certificate of Incorporation and By-Laws limit the monetary
        liability of directors to the Company and to its stockholders and
        provide for indemnification of the Company's officers and
        directors for liabilities and expenses that they may incur in
        such capacities.  In general, officers and directors are
        indemnified with respect to actions taken in good faith in a
        manner reasonably believed to be in, or not opposed to, the best
        interests of the Company, and with respect to any criminal action
        or proceeding, actions that the indemnitee had no reasonable
        cause to believe were unlawful.  The Company also has
        indemnification agreements with its directors and officers that
        provide for the maximum indemnification allowed by law. 

             Thermo Electron Corporation has an insurance policy which
        insures the directors and officers of Thermo Electron and its
        subsidiaries, including the Company, against certain liabilities
        which might be incurred in connection with the performance of
        their duties. 

        Item 16.  Exhibits.

             See the Exhibit Index included immediately preceding the
        exhibits to this Registration Statement.


                                      II-4
PAGE
<PAGE>




        Item 17.  Undertakings.

             (a)  The undersigned Registrant hereby undertakes:

                  (1)       To file, during any period in which offers or
             sales are being made, a post-effective amendment to this
             registration statement:

                       (i)  To include any prospectus required by Section
                            10(a)(3) of the Securities Act of  1933; 

                       (ii) To reflect in the prospectus any facts or
                            events arising after the effective date of
                            the registration statement (or the most
                            recent post-effective amendment thereof)
                            which,  individually or in the aggregate,
                            represent a fundamental change in the 
                            information set forth in the registration
                            statement;

                               (iii)  To include any material information
                            with respect to the plan of distribution not 
                            previously disclosed in the registration
                            statement or any material change to such
                            information in the registration statement; 

             Provided, however, that paragraphs (a) (1) (i) and (a) (1)
        (ii) do not apply if the registration is on Form S-3 or Form S-8,
        and the information required to be included in a post-effective
        amendment by those 
        paragraphs is contained in periodic reports filed by the
        Registrant pursuant to Section 13 or Section 15(d) of the
        Securities Exchange Act of 1934 that are incorporated by
        reference in the registration statement.

                  (2)  That, for the purpose of determining any liability
             under the Securities Act of 1933, each such post-effective
             amendment shall be deemed to be a new registration statement
             relating to the securities offered therein, and the offering
             of such securities at that time shall be deemed to be the
             initial bona fide offering thereof. 

                  (3)  To remove from registration by means of
             post-effective amendment any of the securities being
             registered which remain unsold at the termination of the
             offering.

             (b)  The undersigned Registrant hereby undertakes that, for
        purposes of determining any liability under the Securities Act of
        1933, each filing of the Registrant's annual report pursuant to
        Section 13(a) or Section 15(d) of the Securities Exchange Act of
        1934 (and, where applicable, each filing of an employee benefit
        plan's annual report pursuant to Section 15(d) of the Securities
        Exchange Act of 1934) that is incorporated by reference in the
        registration statement shall be deemed to be a new registration
        statement relating to the securities offered therein, and the

                                      II-5
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<PAGE>




        offering of such securities at that time shall be deemed to be
        the initial bona fide offering thereof.

             (c)  Insofar as indemnification for liabilities arising
        under the Securities Act of 1933 may be permitted to directors,
        officers and controlling persons of the registrant pursuant to
        the foregoing provisions, or otherwise, the registrant has been
        advised that in the opinion of the Securities and Exchange
        Commission such indemnification is against public policy as
        expressed in the Act and is, therefore, unenforceable.  In the
        event that a claim for indemnification against such liabilities
        (other than the payment by the registrant of expenses incurred or
        paid by a director, officer or controlling person of the
        registrant of expenses incurred or paid by a director, officer or
        controlling person of the registrant in the successful defense of
        any action, suit or proceeding) is asserted by such director,
        officer or controlling person in connection with the securities
        being registered, the registrant will, unless in the opinion of
        its counsel the matter has been settled by controlling precedent,
        submit to a court of appropriate jurisdiction the question
        whether such indemnification by it is against public policy as
        expressed in the Act and will be governed by the final
        adjudication of such issue.


































                                      II-6
PAGE
<PAGE>




                                   SIGNATURES

             Pursuant to the requirements of the Securities Act of 1933,
        the Registrant certifies that it has reasonable grounds to
        believe that it meets all of the requirements for filing on Form
        S-3 and has duly caused this Registration Statement to be signed
        on its behalf by the undersigned, thereunto duly authorized, in
        the City of Waltham, Commonwealth of Massachusetts, on the 27th
        day of  March, 1997.

                                      THERMO INSTRUMENT SYSTEMS INC.

                                      By:   /s/ Arvin H. Smith
                                          --------------------
                   By:                      *
                                           Arvin H. Smith
                                           Chairman of the Board and
                                           Chief Executive Officer


             Pursuant to the requirements of the Securities Act of 1933,
        this Registration Statement has been signed by the following
        persons in the capacities and on the dates indicated.

               Signature                   Title               Date
               ---------                   -----               ----


                                  Chairman of the Board,  March 27, 1997
          /s/ Arvin H. Smith *    Chief 
             Arvin H. Smith       Executive Officer and
                                  Director


                                  Vice President, Chief   March 27, 1997
        /s/ John N. Hatsopoulos   Financial Officer
                   *
          John N. Hatsopoulos      and Director
                                  (principal financial
                                  officer)


         /s/ Paul F. Kelleher *   Chief Accounting        March 27, 1997
                                  Officer

            Paul F. Kelleher      (principal accounting
                                  officer)

           /s/ Frank Borman *

              Frank Borman                Director        March 27, 1997

             /s/ George N.
             Hatsopoulos *

                     George N.            Director        March 27, 1997
        Hatsopoulos            



                                      II-7
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<PAGE>




        /s/ Polyvious Vintiadis
                   *
          Polyvious Vintiadis             Director        March 27, 1997



        * By:/s/Jonathan W. Painter
             -----------------------
             Jonathan W. Painter
             Attorney-in-Fact
















































                                      II-8
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<PAGE>





                                  EXHIBIT INDEX
                                  -------------


              Exhibit No.                  Description of Exhibit
              -----------                  ----------------------
                        Description of Exhibit
                  Sequential Page No.
                  -------------------

             5              Opinion of Seth H. Hoogasian, Esq. *


             23.1           Consent of Arthur Andersen LLP


             *  Previously filed.















        AA963170049




































                               ARTHUR ANDERSEN LLP




                    CONSENT OF INDEPENDENT PUBLIC ACCOUNTANTS


        To Thermo Instrument Systems, Inc.:

        As independent public accountants, we hereby consent to the
        incorporation by reference in this registration statement of our
        report dated February 11, 1997 (except with respect to the
        matters discussed in Note 15, as to which the date is March 12,
        1997) included in Thermo Instrument System Inc.'s Form 10-K for
        the year ended December 28, 1996 and to all references to our
        firm included in this registration statement.



                                                /s/ Arthur Andersen LLP


        Boston, Massachusetts
        March 26, 1997



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