BIORELEASE CORP
S-8, 1996-10-31
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                                      Registration No. 33-
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    FORM S-8

                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933

                                BIORELEASE CORP.
             (Exact name of registrant as specified in its charter)

           Delaware                                      88-0218411
(State or other jurisdiction of                       (I.R.S. Employer
 incorporation or organization)                      Identification No.)

       CONSULTANT STOCK OPTIONS DATED JANUARY 25, 1996 AND APRIL 1, 1996,
                      MCGUIRE TAX CONSULTING AGREEMENT AND
     JOHN B. LOWY, ESQ. AND RICHARD FEINER, ESQ. LEGAL CONSULTING AGREEMENT
                              (Full Title of Plan)

        RICHARD SCHUBERT, 10 CHESTNUT DRIVE, UNIT D, BEDFORD, N.H. 03110
                     (Name and Address of Agent for Service)

                                 (603) 471-1255
          (Telephone number including area code, of agent for service)

                         CALCULATION OF REGISTRATION FEE
<TABLE>
<CAPTION>

                                                       Proposed                 Proposed
                                                       Maximum                  Maximum
Title of                                               Offering                 Aggregate                Amount of
Securities                        Amount to be         Price Per                Offering                 Registration
to be Registered                  Registered(1)        Share                    Price                    Fee (1)
- ----------------------------------------------------------------------------------------------------------------
<S>                                <C>                   <C>                   <C>                        <C>         
Common Stock                       250,000               $0.09                 $ 22,500                   $100   (min)
Common Stock (2)                   175,000               $0.09                 $ 15,750
Common Stock (2)                   167,500               $0.06                 $ 10,050
Common Stock (2)                   250,000               $0.18                 $ 45,000
</TABLE>


(1)  The amount being  registered  represents an aggregate of 842,500  Shares of
     Common Stock,  592,500 of which are issuable upon exercise of a like number
     of options,  which options were issued  pursuant to the  respective  Plans.
     Pursuant to Rule 416(c)  promulgated  under the  Securities Act of 1933, as
     amended, the Registration  Statement also covers an indeterminant amount of
     shares to be  offered  or sold as a result of any  adjustments  from  stock
     splits, stock dividends or similar events.

(2)  Issuable upon exercise of options.


<PAGE>


  PART I. INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS

Item 1. Plan(s) Information

     The  information  required by Part I is included in documents sent or given
to participants in the Consultant Stock Options dated January 25, 1996 and April
1, 1996,  the McGuire Tax  Consulting  Agreement and the John B. Lowy,  Esq. and
Richard Feiner, Esq. Legal Consulting Agreement pursuant to Rule 428 (b) (1).

   PART II. INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 3. Incorporation of Documents by Reference


     The Registrant is subject to the information requirements of the Securities
Exchange  Act of 1934 and,  in  accordance  therewith,  files  reports  with the
Securities and Exchange  Commission  (the  "Commission").  The documents  listed
below are hereby  incorporated  by reference in this  Registration  Statement on
Form S-8; and all documents  subsequently  filed by the  Registrant  pursuant to
Sections 13(a),  13(c), 14 and 15(d) of the Exchange Act, prior to the filing of
a post-effective amendment which indicates that all securities offered have been
sold or which deregisters all securities then remaining unsold,  shall be deemed
to be incorporated  herein by reference in this  Registration  Statement on Form
S-8, and shall be a part hereof from the date of the filing of such documents.

(a)  The  Registrant's  annual  report of Form  10-KSB for the fiscal year ended
     June 30, 1996; and

(b)  All other  reports  filed by the  Registrant  pursuant to Section  13(a) or
     15(d) of the Exchange Act since June 30, 1996; and

(c)  The description of the Common Stock which is contained in the  registration
     statement  filed under the Exchange Act,  including any amendment or report
     filed for the purpose of updating such description.


Item 4. Description of Securities

     Not applicable.


Item 5. Interests of Named Experts and Counsel

     The validity of the  authorization and issuance of the Common Stock will be
passed upon by John B. Lowy,  P.C.,  Suite 403, 645 Fifth Avenue,  New York, New
York 10022.

                                      - 2 -

<PAGE>


Item 6. Indemnification of Directors and Officers

Section  145 of  the  Delaware  General  Corporation  Law  empowers  a  Delaware
corporation to indemnify any person who is, or is threatened to be made, a party
to any  threatened,  pending or completed  action,  suit or  preceding,  whether
civil, criminal,  administrative or investigative (other than an action by or in
the right of such  corporation) by reason of the fact that such person is or was
an officer or director of such corporation,  or is or was serving at the request
of such  corporation  as a  director,  officer,  employee  or agent  or  another
corporation  or  enterprise.  The  indemnity  may  include  expenses  (including
attorney's fees),  judgments,  fines and amounts paid in settlement actually and
reasonably  incurred  by such person in  connection  with such  action,  suit or
proceeding,  provided  that he acted in good faith and in a manner he reasonably
believed to be in or not opposed to the best interests of the corporation,  and,
with respect to any criminal  action or proceeding,  has no reasonable  cause to
believe his conduct was unlawful.  A Delaware corporation may indemnify officers
and directors in an action by or in the right of the corporation  under the same
conditions,  except  that  no  indemnification  is  permitted  without  judicial
approval if the officer or director is adjudged to be liable for  negligence  or
misconduct in the performance of his duty to the  corporation.  Where an officer
or  director  is  successful  on the merits or  otherwise  in the defense of any
action  referred  to above,  the  corporation  must  indemnify  him  against the
expenses which he actually and reasonably incurred in connection therewith.  The
indemnification  provided is not deemed to be  exclusive  of any other rights to
which an officer or director may be entitled under a corporation's  by-laws,  an
agreement, vote or otherwise.

   Section  102(b)(7)  of the  Delaware  General  Corporation  Law,  as amended,
permits a corporation  to provide in its  certificate  of  incorporation  that a
director of the corporation shall not be personally liable to the corporation or
its  stockholders  for  monetary  damages  for  breach  of  fiduciary  duty as a
director,  except for  liability  (i) for any breach of the  director's  duty of
loyalty to the corporation or its  stockholders,  (ii) for acts or omissions not
in good faith or which involve intentional  misconduct or a knowing violation of
law, (iii) under Section 174 of the Delaware  General  Corporation  Law, or (iv)
for any  transaction  from which a the  director  derived an  improper  personal
benefit.

   Article EIGHTH of the Registrant's Certificate of Incorporation,  as amended,
sets forth the extent to which  directors and officers of the  Registrant may be
indemnified  against  liabilities  which  they  incur  in  their  capacities  as
directors  of officers of the  Registrant.  Article  EIGHTH also  provides  that
director  of the  Registrant  shall  not be  liable  to  the  Registrant  or its
stockholders  for monetary damages for breach of fiduciary duty as a director to
the  fullest  extent  such  limitation  is  permitted  by the  Delaware  General
Corporation Law.

Article V of the Company's By-Laws provides as follows:

The  corporation  shall  indemnify  any and all of its  Directors or Officers or
former Directors or Officers or any person who may have served at its request as
a Director or Officer of another  corporation in which it owns shares of capital
stock or of which it is a creditor  against  expenses  actually and  necessarily
incurred  by  them  in  connection  with  the  defense  of any  action,  suit or
proceeding  in which they,  or any of them,  are made  parties,  or a party,  by
reason of being or having been Directors or Officers or a Director or Officer of
the corporation, or of such other corporation, except, in relation to matters as
to which any such

                                      - 3 -

<PAGE>


Director or Officer or former Director or Officer or person shall be adjudged in
such action, suits or proceedings to be liable for negligence or misconduct,  in
the performance of duty. Such  indemnification  shall not be deemed exclusive or
any others'  rights to which those  indemnified  may be entitled,  under By-Law,
agreement, vote of stockholders or otherwise.

Item 7. Exemption from Registration Claimed

     Not  Applicable.

Item 8. Exhibits

4.1  Certificate of Incorporation of the Registrant(1)

4.2  Amendment to Certificate of  Incorporation  of the Registrant  changing the
     name of the Corporation to Biorelease Corp.(1)

4.3  By-Laws, as amended, of the Registrant(1)

4.4  Minutes  dated  January  25,  1996 and April 1, 1996  awarding  consultants
     non-statutory options.

4.5  John B. Lowy, Esq. and Richard Feiner, Esq., Legal Consulting Agreement.

4.6  McGuire Tax Consulting Agreement.

4.7  Opinion of John B. Lowy, P.C. with consent.

4.8  Consent of Berry,  Dunn,  McNeil & Parker  (formerly  Smith,  Batchelder  &
     Rugg), independent accountants.

- -----------
(1)  Previously  filed with the  Commission  as an  Exhibit to the  Registrant's
     Registration Statement on Form S-1, as amended, File No. 33-43976 which was
     originally filed with the Commission November 14, 1991.


Item 9. Undertakings

1.   The undersigned  Registrant  hereby undertakes to file during any period in
     which  offers or sales are being made, a  post-effective  amendment to this
     Registration  Statement to include any material information with respect to
     the plan of  distribution  not  previously  disclosed  in the  Registration
     Statement or any material  change to such  information in the  Registration
     Statement.

2.   The  undersigned  Registrant  hereby  undertakes  that,  for the purpose of
     determining  any  liability  under the  Securities  Act of 1933,  each such
     post-effective amendment shall be deemed to be a new registration statement
     relating  to the  securities  offered  therein  and  the  offering  of such
     securities  at that  time  shall be  deemed  to be the  initial  bona  fide
     offering thereof.

                                      - 4 -

<PAGE>


3.   The undersigned Registrant hereby undertakes to remove from registration by
     means of a post-effective  amendment any of the securities being registered
     which remain unsold at the termination of the offering.

4.   The  undersigned   Registrant   hereby  undertakes  that  for  purposes  of
     determining  any liability under the Securities Act of 1933, each filing of
     the Registrant's  annual report pursuant to Section 15(d) of the Securities
     Exchange Act of 1934 that is incorporated by reference in the  registration
     statement shall be deemed to be a new registration statement related to the
     securities  offered  therein,  and the offering of such  securities at such
     time shall be deemed to be the initial bona fide offering thereof.

5.   Insofar as indemnification for liabilities arising under the Securities Act
     of 1933 may be permitted to directors, officers, and controlling persons of
     the  Registrant  pursuant to the foregoing  provisions,  or otherwise,  the
     Registrant  has been advised in the opinion of the  Securities and Exchange
     Commission  such  indemnification  is against public policy as expressed in
     the Act and is,  therefore,  unenforceable.  In the event  that a claim for
     indemnification  against  such  liabilities  (other than the payment by the
     Registrant  of  expenses  incurred  or  paid  by  a  director,  officer  or
     controlling  person of the  Registrant  in the  successful  defense  of any
     action,  suit or  proceeding)  is  asserted  by such  director,  officer or
     controlling person in connection with the securities being registered,  the
     Registrant  will,  unless in the opinion of its counsel the matter has been
     settled  by  controlling  precedent,  submit  to  a  court  of  appropriate
     jurisdiction  the question  whether such  indemnification  by it is against
     public  policy as  expressed  in the Act and will be  governed by the final
     adjudication of such issue.

                                      - 5 -

<PAGE>


                                   SIGNATURES

     Pursuant  to the  requirements  of  Section  13 or 15(d) of the  Securities
Exchange Act of 1934, the registrant certifies that it has reasonable grounds to
believe  that it meets all of the  requirements  for  filing on Form S-8 and has
duly caused this  registration  statement on Form S-8 to be signed on its behalf
by the undersigned,  thereunto duly authorized,  in Salem, New Hampshire, on the
date set forth below.

                                                    BIORELEASE CORP.
Dated: October 17, 1996                       By:   /s/ Richard Schubert
                                                    ---------------------
                                                    Richard Schubert, Chairman

     Pursuant  to  the   requirements  of  the  Securities  Act  of  1933,  this
registration  statement has been signed below by the following persons on behalf
of the Company and in the capacities and on the dates indicated.
<TABLE>
<CAPTION>


SIGNATURES                                    TITLE                                       DATE


<S>                          <C>                                                  <C> 
/s/ Richard Schubert         Chairman, Principal Executive Officer,               October 17, 1996
- ----------------------       Principal Financial and Accounting
Richard Schubert             Officer and Director 
                                              


- ----------------------       Director                                             October __, 1996
Paul Calvin Maybury



/s/ Richard Whitney         Director                                              October  10, 1996
- ----------------------
Richard Whitney
</TABLE>

                                      - 6 -

<PAGE>


EXHIBIT 4.4

                         UNANIMOUS CONSENT OF DIRECTORS

                     IN LIEU OF MEETING OF BIORELEASE CORP.


     The undersigned,  constituting all of the members of the Board of Directors
of Biorelease  Corp., a Delaware  corporation do hereby consent to the following
action effective as of January 25, 1996:

     The "Ad hoc" compensation  committee  (Directors Reeves and Whitney) having
     met by  teleconference  on  January  22  and  January  23,  1996  and  upon
     recommendation  therefrom the Board of Directors of biorelease Corp. hereby
     unanimously  approves the issue of  non-statutory  options to acquire up to
     691,700 share of common stock in the Corporation  under the following terms
     and  conditions  at an exercise  price of $.06 per share.  a premium of 50%
     above the closing price both on January 23 and the effective date hereof

          To R. Bruce  Reeves an option to acquire  up to 416,700  fully  vested
          shares in exchange for his agreement not to draw down $25,000 due this
          date in  compensation  before June 30, 1996 in order to help alleviate
          critical cash flow requirement of the  Corporation,  it being noted if
          to acquire the Company's stock on the open market at a lower price, it
          being  further  noted  that the Board has  determined  no new  options
          relating to salary accrual and deferment  thereof will be issued for a
          period  through at least  December 31, 1998.  The ad hoc  committee is
          admonished to find alternate,  non dilutive methods to cover executive
          compensation during low cash flow periods

          To Joseph Mo an option to acquire up to 75,000 shares, 37,500 of which
          are  fully  vested  for past  and  present  consulting  in the area of
          financing, acquisition and pharmaceutical development, 37,500 of which
          shall vest upon  completion  of an  acquisition  or merger with Conrex
          Pharmaceutical prior to calendar year end 1996

          To Paul  Leibowitz an option to acquire up to 200,000  shares,  60,000
          vested which shall replace  60,000  existing  vested  options  earlier
          issued to Dr. Leibowitz which earlier options shall be cancelled,  for
          additional  past and  present  consulting  in the  area of  financing,
          acquisition  and  scientific  advisory  activities  and 70,000  shares
          contingent on acquiring  technology or  completing an  acquisition  or
          merger other than Conrex Pharmaceutical on or before calendar year end
          1996 for which  Leibowitz is engaged in review and  assessment of such
          technology

                                     - 7 -

<PAGE>


     All  options,  upon  vesting  shall be  exercisable  anytime  on or  before
     December 31, 1999 after which all rights  thereunder  shall  expire  unless
     extended  by the  Board  of  Directors.  All  underlying  shares  shall  be
     registered on Form S8 at the earliest practical date.

     The Board  further  consents  to the issue of 17,771  restricted  shares to
     creditors in the  following  amounts and hereby  ratifies  the  settlements
     related thereto

          Clonetech Laboratories, Inc.                 ( 280 sh)
          Ferdinando Insurance, Inc.                   (2471 sh)
          Reed Elsevier Assoc. Inc.                    (4080 sh)
          Medical Economics Publishing, Inc.           (2189 sh)
          Gen Publishing Inc.                          (8751 sh)





Unanimously agreed to as of the effective date stated above.




                                               /s/ R. Bruce Reeves
                                               -------------------------
                                               R. Bruce Reeves, Director


                                               /s/ P. Cal Maybury
                                               -------------------------
                                               P. Cal Maybury, Director


                                               /s/ Richard F. Schubert
                                               -------------------------
                                               Richard F. Schubert, Director


                                               /s/ Richard Whitney
                                               -------------------------
                                               Richard Whitney, Director

                                     - 8 -

<PAGE>


                         UNANIMOUS CONSENT OF DIRECTORS

                     IN LIEU OF MEETING OF BIORELEASE CORP.


     The undersigned,  constituting all of the members of the Board of Directors
of Biorelease Corp., a Delaware corporation,  do hereby consent to the following
action effective as of April 1, 1996:

Due to severe  lack of  liquidity,  the  Corporation  has been unable to pay the
President/CEO  on a  current  basis  and due to the  continuing  uncertainty  of
providing  health  insurance as required under existing  agreements  between the
corporation and the  President/CEO,  the Board of Directors of Biorelease  Corp.
hereby unanimously

     VOTES to approve the transfer to R T Robertson Consultants,  Inc., a Reeves
     family controlled entity (ROBERTSON),  all Reeves contract rights, unissued
     options and net accounts  receivable  which amount to $83,379.14 at 3/31/96
     inclusive of applicable payroll tax. The corporation shall engage ROBERTSON
     as  its  exclusive  consultant  to  provide  executive  oversight  for  the
     Corporation. Reeves shall become a full time employee of ROBERTSON and will
     continue to serve as President/CEO of the Corporation. All compensation and
     health benefits comparable to those previously provided by the Corporation,
     shall be provided to Reeves by ROBERTSON and reimbursed on a timely fashion
     by the  Corporation  to ROBERTSON.  Any and all options not vested at March
     31, 1996 shall vest under their terms except for  requirements  to continue
     as an employee  which shall be deemed met by the  undertaking  hereunder to
     allow Reeves to serve as President/CEO  while employed by ROBERTSON.  As is
     the case with the former  agreement  between  the  Corporation  and Reeves,
     ROBERTSON  can be  terminated  with six months  notice  accompanied  by the
     compensation  for the notice  period.  As stated  above,  all  options  and
     underlying shares shall be issued in the name of ROBERTSON or its successor
     or assigns.

Paul  Liebowitz,  a consultant to the Corporation  and scientific  advisor,  has
agreed to spend  substantial  time over the following three months to assist the
President/CEO in establishing strategic partnerships and corporate relationships
and investment banking relationships, such consulting shall not include the sale
of the Company's securities.  Because Dr. Leibowitz will be working on behalf of
the  Corporation  without  salary or cash  compensation,  the Board of Directors
hereby VOTES

     to issue to Paul Leibowitz and additional  non-statutory  option  (separate
     from the option for up to 200,000  shares  granted on January 25,  1996) to
     acquire up to 350,000 shares of common stock in the  Corporation  under the
     following terms and conditions

                                     - 9 -

<PAGE>


          100,000  underlying  shares  shall  vest  ratably  over the next three
          months at an exercise  price of $.09,  the closing  price on March 29,
          1996

          The remaining 250,000 shall vest in the following manner

               150,000  shall vest with the  completion  of a patent  review and
               resubmission  as  deemed  necessary  of  the  Subsidiary's  NO/CO
               intellectual  property  position relating to its blood substitute
               stabilization technologies.

               The  additional  100,000  option shares shall vest if and when an
               agreement  is  reached   with  the   Leibowitz   managing   group
               (Leibowitz,  Strange and  Fleming)  relating to a reverse  merger
               with the Company and the  initiation of a merger and  acquisition
               activity within Biorelease.

          The exercise price of these  additional  250,000 shares shall be $0.18
          per share, twice the closing price on March 29, 1996.

          Subject  to  opinion of counsel  John  Lowy,  all  350,000  underlying
          Leibowitz  shares  shall be  registered  on Form  S-8 at the  earliest
          practical  date  and  shall  expire  if  not  exercised  on or  before
          12/31/04.

Unanimously agreed to as of the effective date stated above.

                                               /s/ R. Bruce Reeves
                                               -------------------------
                                               R. Bruce Reeves, Director

                                               /s/ P. Cal Maybury
                                               -------------------------
                                               P. Cal Maybury, Director

                                               /s/ Richard F. Schubert
                                               -------------------------
                                               Richard F. Schubert, Director

                                               /s/ Richard Whitney
                                               -------------------------
                                               Richard Whitney, Director

                                     - 10 -

<PAGE>


EXHIBIT 4.5

                           LEGAL CONSULTING AGREEMENT

     This Agreement is made and entered into as of the 1st day of October,  1996
by and between JOHN B. LOWY, ESQ. ("JBL") and RICHARD FEINER,  ESQ. ("RF"), both
with principal  offices at 645 Fifth Avenue,  New York, NY 10022, and BIORELEASE
CORP., a Delaware  corporation  (the "Company") with its principal  office at 10
Chestnut Drive, Unit D, Bedford, NH 03110.

     WHEREAS,  JBL and RF rendered legal consulting services to the Company from
July 1, 1995 through September 30, 1996; and

     WHEREAS,  the parties hereto desire to memorialize  JBL's and RF's services
and compensate JBL and RF therefor;

     NOW, THEREFORE, in consideration of the mutual promises made herein and for
other good and valuable  consideration,  the receipt and sufficiency of which is
hereby acknowledged, the parties hereto agree as follows:

     1. Purpose:  The Company hereby  recognizes and agrees that JBL and RF have
rendered  legal  consulting  advice  to the  Company  specifically  relating  to
transactions, not of a capital raising nature ("Legal Consulting Services").

     2.  Compensation:  In  consideration  for  the  Legal  Consulting  Services
rendered by JBL and RF to the Company  valued at $21,875 as  recognized  in this
Agreement,  the  Company  hereby  agrees  to issue to JBL and RF,  respectively,
122,500 and 52,500 shares of the Company's Common Stock (the "Shares").  JBL and
RF hereby acknowledge that the aforementioned 175,000 Shares are in full payment
for the $21,875 due them. JBL and RF further acknowledge receipt of an aggregate
of 160,000 of these shares.

     3.  Registration:  The Company  hereby agrees to  immediately  register the
Shares pursuant to a Registration Statement on Form S-8.

     4. JBL and RF are  Independent  Contractors:  JBL and RF have performed the
Legal Consulting Services described herein as independent contractors and not as
an employees of the Company or an affiliates thereof.

     5. Miscellaneous:

                    (a)  This  Agreement  between  the  Company  and  JBL and RF
constitutes the entire agreement and  understanding  of the parties hereto,  and
supersedes any and all previous  agreement and  understandings,  whether oral or
written, between the parties with respect to the matters set for herein.

                    (b)  Any  notice  or  communication  permitted  or  required
hereunder  shall  be in  writing  and  shall  be  deemed  sufficiently  given if
hand-delivered  or sent (i) postage prepaid by registered  mail,  return receipt
requested,  or (ii) by facsimile,  to the respective parties as set forth above,
or to such other address as either party may notify the other in writing.


                    (c) This  Agreement  shall be binding  upon and inure to the
benefit of each of the parties  hereto and their  respective  successors,  legal
representatives and assigns.

                                     - 11 -

<PAGE>


                    (d)  This  Agreement  may  be  executed  in  any  number  of
counterparts,  each of which together shall constitute one and the same original
document.

                    (e) No provision of this Agreement may be amended,  modified
or waived, except in a writing signed by all of the parties hereto.

                    (f) This Agreement shall be construed in accordance with and
governed by the laws of the State of New York, without giving effect to conflict
of law  principles.  The parties  hereby agree that any dispute  which may arise
between  them  arising  out of or in  connection  with this  Agreement  shall be
adjudicated  before a court  located in New York,  and they hereby submit to the
exclusive  jurisdiction  of the  courts of the State of New York  located in New
York, New York and of the federal courts of the State of New York located in New
York,  New York and of the federal  courts in the Southern  District of New York
with  respect  to any action or legal  proceeding  commenced  by any party,  and
irrevocably  waive any objections  they now or hereafter may have respecting the
venue of any such action or proceeding brought in such a court or respecting the
fact that such court is an  inconvenient  forum,  relating  to or arising out of
this  Agreement,  and  consent to the  service of process in any such  action or
legal  proceeding  by means of  registered  or certified  mail,  return  receipt
requested, in care of the address set forth in Paragraph 8(b) hereof.

     IN WITNESS  WHEREOF,  the parties  hereto have caused this  Agreement to be
duly executed, as of the day and year first above written.



                                 /s/John B. Lowy
                                 -------------------------
                                 JOHN B. LOWY, ESQ.



                                /s/Richard Feiner
                                -------------------------
                                RICHARD FEINER, ESQ.


                                BIORELEASE CORP.



                  By:           /s/Richard Schubert
                                -------------------------
                                Richard Schubert, Chairman

                                     - 12 -

<PAGE>


EXHIBIT 4.6

                          McGuire's Tax & Finance, Inc.
                                148 Robinson Road
                                Hudson, NH 03051
                               Ph. (603) 882-3139
                             Fax/Data (603) 882-7053

BY FAX

August 28, 1996

R. Bruce Reeves, President/CEO
Biorelease Corp.
10 Chestnut Drive Unit D
Bedford, NH 03110

Dear Bruce;

     This letter represents confirmation of our meeting relative to services and
compensation  for the Company's  accounting and tax requirements for fiscal year
ended June 30, 1996.

     Our firm,  specifically  Vivian  and Kevin  McGuire,  have  maintained  the
integrity of the accounting  records,  prepared  quarterly and annual  financial
statements  for  management  and assisted in the  preparation  of quarterly  and
annual SEC filing  reports  for the  Company,  its  directors  and  officers  as
required.  Such records and filings have been presented in an auditable form and
are in conformity with generally accepted accounting principles and Security and
Exchange Commissions rules and regulations.  Additionally, our firm will prepare
such  income tax filings for 1994 and 1995 that will  maintain  compliance  with
applicable federal and state requirements.

     In  consideration  and full  payment  of our  services,  McGuire's  Tax and
Finance, Inc. will accept the following:

     1. 75,000 shares of Biorelease  Corp common stock,  par $.01 valued at $.09
     per share.

     2. 75,000 fully vested options valued at $.09 per share,  the closing price
     on August 28, 1996.

     3. Any  additional  fees for services,  in excess of the value of the above
     referenced shares and options, will billed separately at the going rate for
     such services.

     Such shares and  options are to be issued in the name of Vivian L.  McGuire
Kevin T. McGuire, JTWROS (Tax ID ###-##-####) and registered with the Securities
and Exchange  Commission  upon the completion of the Company's  annual audit and
filing of it's annual report to the Securities  and Exchange  Commission on Form

                                     - 13 -

<PAGE>


10-KSB due  September  30, 1996.  Upon receipt of said shares,  all  outstanding
income  tax  returns  will be  presented  for  filing.  As always,  all  ongoing
accounting  services  related  to the year  ended  June 30,  1996 will  continue
un-interrupted.

     If such concurs  with your  understanding,  please  return a signed copy of
this  letter to our  office  representing  your  acceptance  of these  terms and
instruct the Company's SEC counsel,  John B. Lowy, P. C. to make the appropriate
inclusion in a registration  statement on Form S-8 to be filed  concurrent  with
the Company's annual report.

     We thank you for consideration of our firm to perform said services.



Respectfully,

/s/ V. L. McGuire
- -----------------
V. L. McGuire,
President


By the below  signature of a duly  authorized  director or officer of Biorelease
Corp, the Company accepts the terms of this agreement.


/s/ R. Bruce Reeves
- -------------------
R. Bruce Reeves, President/CEO  08-28-96

                                     - 14 -

<PAGE>


EXHIBIT 4.7

                       [LETTERHEAD OF JOHN B. LOWY, P.C.]



                                October 17, 1996


Biorelease Corp.
10 Chestnut Drive
Unit D
Bedford, New Hampshire 03110.

Gentlemen:

     We have reviewed a  Registration  Statement on Form S-8 (the  "Registration
Statement"),  to be filed with the Securities and Exchange Commission,  relating
to 842,500  shares of common stock,  $.01 par value per share (the  "Shares") of
Biorelease  Corp.  (the  "Company"),  592,500  shares of which are issuable upon
exercise of 592,500 options,  which shares and options have been issued pursuant
to the Company's consulting  agreements and plans described in the minutes filed
as exhibits to the Registration Statement (collectively, the "Agreement").

     We have examined the  Certificate  of  Incorporation,  as amended,  and the
By-Laws of the Company and all amendments therefor,  the Registration  Statement
and  originals,  or copies  certified  to our  satisfaction,  of such records of
meetings  written  actions  in lieu  of  meetings,  or  resolutions  adopted  at
meetings,  of the directors of the Company,  documents and such other  documents
and  instruments as in our judgment are necessary or appropriate to enable us to
render the opinions expressed below.

     In examination of the foregoing documents,  we have assumed the genuineness
of all  signatures  and the  authenticity  of all  documents  submitted to us as
originals, the conformity to original documents of all documents submitted to us
as certified or photostatic  copies,  and the  authenticity  of the originals of
such latter documents.

     Based upon and subject to the  foregoing,  we are of the  opinion  that the
Shares have been duly and validly  authorized  for issuance  under the Agreement
and the Shares,  when issued  against  payment  therefor in accordance  with the
terms of the Agreement and the options,  will be legally issued,  fully paid and
nonassessable.

     We hereby  consent  to the  filing of this  opinion  as an  Exhibit  to the
Registration Statement.

                                              Very truly yours,

JBL:ah                                        John B. Lowy, P.C.

                                     - 15 -

<PAGE>


EXHIBIT 4.8

                  (LETTERHEAD OF BERRY, DUNN, McNEIL & PARKER)

                         INDEPENDENT AUDITORS' CONSENT

The Board of Directors
BioRelease Corp.

We consent to  incorporation  by reference in Form S-8 of BioRelease  Corp.  and
Subsidiary  of our report dated  September  13, 1996,  except for Note 12, as to
which the date is October 8, 1996, relating to the consolidated balance sheet of
BioRelease   Corp.  and  Subsidiary  as  of  June  30,  1996,  and  the  related
consolidated  statements of operations,  shareholder's equity (deficit) and cash
flows for the year ended June 30, 1996, which report is included in the June 30,
1996, annual report on Form 10-KSB.

/s/ Berry, Dunn, McNeil & Parker
- --------------------------------
Berry, Dunn, McNeil & Parker

Manchester, New Hampshire
October 30, 1996

                                     - 16 -



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