<PAGE> PAGE 1
000 B000000 12/31/93
000 C000000 799127
000 D000000 N
000 E000000 NF
000 F000000 Y
000 G000000 N
000 H000000 N
000 I000000 3.0.a
000 J000000 U
001 A000000 VANGUARD QUANTITATIVE PORTFOLIOS, INC.
001 B000000 811-4526
001 C000000 6106691000
002 A000000 100 VANGUARD BOULEVARD
002 B000000 MALVERN
002 C000000 PA
002 D010000 19355
003 000000 N
004 000000 N
005 000000 N
006 000000 N
007 A000000 N
007 B000000 0
018 000000 Y
019 A000000 Y
019 B000000 75
019 C000000 VANGUARDGR
020 A000001 JEFFERIES & CO., INC.
020 B000001 95-2622900
020 C000001 211
020 A000002 FRANK RUSSELL SECURITIES INC.
020 B000002 91-0604934
020 C000002 107
020 A000003 INSTINET CORPORATION
020 B000003 13-3443395
020 C000003 48
020 A000004 ARIZONA EXCHANGE
020 C000004 45
020 A000005 MERRILL LYNCH PIERCE FENNER & SMITH
020 B000005 13-5674085
020 C000005 17
020 A000006 PAINE WEBBER, INC.
020 B000006 13-2638166
020 C000006 12
020 A000007 FIDELITY BROKERAGE SERVICES, INC.
020 B000007 04-2653569
020 C000007 10
020 A000008 PRUDENTIAL BACHE SECURITIES
020 B000008 13-1954348
020 C000008 10
020 A000009 FIRST BOSTON CORP.
020 B000009 13-5659485
<PAGE> PAGE 2
020 C000009 9
020 A000010 ABEL NOSSER CORP.
020 B000010 13-2833083
020 C000010 8
021 000000 512
022 A000001 THE VANGUARD GROUP, INC./POOLED CASH ACCT.
022 B000001 23-1945930
022 C000001 3222928
022 D000001 0
022 A000002 HERZOG, HEINE GEDULD, INC.
022 B000002 13-1955436
022 C000002 0
022 D000002 2105
022 A000003 FIRST BOSTON CORP.
022 B000003 13-5659485
022 C000003 1262
022 D000003 425
022 A000004 J.P. MORGAN & CO., INC.
022 C000004 192
022 D000004 0
022 A000005 FLEMING COMPANIES, INC.
022 C000005 59
022 D000005 0
022 A000006 INVESTMENT TECHNOLOGY GROUP, INC.
022 B000006 95-4339369
022 C000006 57
022 D000006 0
022 C000007 0
022 D000007 0
022 C000008 0
022 D000008 0
022 C000009 0
022 D000009 0
022 C000010 0
022 D000010 0
023 C000000 3224498
023 D000000 2530
028 A010000 13912
028 A020000 0
028 A030000 0
028 A040000 3783
028 B010000 13044
028 B020000 0
028 B030000 0
028 B040000 6781
028 C010000 11026
028 C020000 0
028 C030000 0
028 C040000 4751
028 D010000 12079
028 D020000 0
<PAGE> PAGE 3
028 D030000 0
028 D040000 3611
028 E010000 11608
028 E020000 0
028 E030000 0
028 E040000 4150
028 F010000 18225
028 F020000 53575
028 F030000 0
028 F040000 5877
028 G010000 79894
028 G020000 53575
028 G030000 0
028 G040000 28953
028 H000000 0
062 A000000 N
062 B000000 0.0
062 C000000 0.0
062 D000000 0.0
062 E000000 0.0
062 F000000 0.0
062 G000000 0.0
062 H000000 0.0
062 I000000 0.0
062 J000000 0.0
062 K000000 0.0
062 L000000 0.0
062 M000000 0.0
062 N000000 0.0
062 O000000 0.0
062 P000000 0.0
062 Q000000 0.0
062 R000000 0.0
071 A000000 452935
071 B000000 382204
071 C000000 452125
071 D000000 85
072 A000000 12
072 B000000 406
072 C000000 12213
072 D000000 0
072 E000000 0
072 F000000 1075
072 G000000 479
072 H000000 0
072 I000000 560
072 J000000 5
072 K000000 0
072 L000000 39
072 M000000 1
072 N000000 0
<PAGE> PAGE 4
072 O000000 38
072 P000000 0
072 Q000000 0
072 R000000 9
072 S000000 0
072 T000000 109
072 U000000 0
072 V000000 6
072 W000000 0
072 X000000 2321
072 Y000000 0
072 Z000000 10298
072AA000000 74689
072BB000000 13248
072CC010000 0
072CC020000 12404
072DD010000 10830
072DD020000 0
072EE000000 48656
073 A010000 0.3900
073 A020000 0.0000
073 B000000 1.6900
073 C000000 0.0000
074 A000000 0
074 B000000 12353
074 C000000 422
074 D000000 0
074 E000000 0
074 F000000 524186
074 G000000 0
074 H000000 0
074 I000000 85
074 J000000 33363
074 K000000 0
074 L000000 3039
074 M000000 0
074 N000000 573448
074 O000000 40099
074 P000000 283
074 Q000000 0
074 R010000 0
074 R020000 0
074 R030000 0
074 R040000 2330
074 S000000 0
074 T000000 530736
074 U010000 32260
074 U020000 0
074 V010000 16.45
074 V020000 0.00
074 W000000 0.0000
<PAGE> PAGE 5
074 X000000 29593
074 Y000000 0
075 A000000 0
075 B000000 464052
076 000000 0.00
077 A000000 Y
077 B000000 Y
077 C000000 N
077 D000000 N
077 E000000 N
077 F000000 N
077 G000000 N
077 H000000 N
077 I000000 N
077 J000000 N
077 K000000 N
077 L000000 N
077 M000000 N
077 N000000 N
077 O000000 N
077 P000000 N
077 Q010000 N
077 Q020000 N
077 Q030000 N
078 000000 N
080 A000000 ICI MUTUAL INSURANCE COMPANY
080 C000000 110000
081 A000000 Y
081 B000000 91
082 A000000 N
082 B000000 0
083 A000000 N
083 B000000 0
084 A000000 N
084 B000000 0
085 A000000 Y
085 B000000 N
SIGNATURE GARY P. SOURA
TITLE ASST. VICE PRESIDENT
