VANGUARD QUANTITATIVE PORTFOLIOS INC
24F-2NT, 1995-02-15
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February 15, 1995




Securities and Exchange Commission
450 5th Street, N.W.
Washington, D.C. 20549

Re:  Vanguard Quantitative Portfolios, Inc.
     File No. 33-8553

Gentlemen:

Pursuant to Rule 24f-2 under the Investment Company Act of 1940, Vanguard
Quantitative Portfolios, Inc. (the "Fund") hereby files its Rule 24f-2
Notice for the fiscal year ended December 31, 1994.  A wire transfer in the
amount of $19,981.00 in payment of the registration fee due for the Fund's
Rule 24f-2 filing has been sent to the lockbox at Mellon Bank in Pittsburgh
for deposit to the Securities and Exchange Commission's account number 910-
8739.

1.   At the beginning of the fiscal year, the Fund had the following
securities registered under the Securities Act of 1933(the "1933 Act")
other than pursuant to Rule 24f-2, but which remained unsold:

                                                    Aggregate Offering
                                                    Price of Shares on
                                                    which Registration
Name of Securities         Number of Shares            Fee was Paid

Shares of Common Stock           None                       None
($.001 Par Value)

2.   During the fiscal year the Fund registered the following securities
under the 1933 Act other than pursuant to Rule 24f-2:

                                                    Aggregate Offering
                                                    Price of Shares on
                                                    which Registration
Name of Securities          Number of Shares            Fee was Paid

Shares of Common Stock            None                       None
($.001 Par Value)

3.   The number and the aggregate sales price of shares of the Fund sold
during the fiscal year was as follows:

Name of Securities           Number of Shares      Aggregate Sales Price

Shares of Common Stock          12,877,090               $203,670,033
($.001 Par Value)

4.   The number and aggregate sales price of shares of the Fund sold during
the fiscal year in reliance upon registration pursuant to Rule 24f-2 is as
follows (See footnote attached as Exhibit A hereto):

Name of Securities            Number of Shares      Aggregate Sales Price

Shares of Common Stock           12,877,090             $203,670,033
($.001 Par Value)

Enclosed is an opinion of counsel (Exhibit B) indicating that the
securities sold in reliance upon Rule 24f-2 were legally issued, fully paid
and non-assessable.

Very truly yours,

VANGUARD QUANTITATIVE PORTFOLIOS, INC.

BY:  (Raymond J. Klapinsky)
     Secretary



                                  EXHIBIT "A"

                        FOOTNOTE TO RULE 24F2 NOTICE OF
                     VANGUARD QUANTITATIVE PORTFOLIOS, INC.




The calculation of the registration fee pursuant to subsction (c) of Rule
24f-2 is set forth below.  The Fund did not apply any redemptions or
repurchases which took place during the fiscal year to the registration of
any securities pursuant to Section 24(e) of the Investment Company Act.



<TABLE>
<CAPTION>

                                    (a)                         (b)                        (c)                 (d)
                              Aggregate Sales            Aggregate Price of          Aggregate Sales       Fee Payable
                            Price of Securities         Securities Redeemed           Price on which       pursuant to
                             Sold in Reliance             or Repurchased            fee will be based      Section 6(b)
                             upon Rule 24f-2             During Fiscal Year            (a minus b)          of 1933 Act
<S>                            <C>                         <C>                          <C>                   <C>
Vanguard Quantitative
Portfolios, Inc.
Shares of Common 
Stock ($.001 Par
Value)                         $203,670,033                 $133,522,914                  $70,147,119           $24,188.83


</TABLE>






                                  EXHIBIT "B"


February 15, 1995



Vanguard Quantitative Portfolios, Inc.
1300 Morris Drive, P.O. Box 876
Valley Forge, PA 19482

Gentlemen:

Vanguard Quantitative Portfolios, Inc. (the "Fund") is a corporation
rganized under Maryland law.  I have acted as legal counsel to the Fund
since its initial registration as an open-ended management investment
company under the Investment Company Act of 1940 ("1940 Act"), as amended.
It is in my capacity as counsel to the Fund that I am furnishing you this
opinion.

I have examined the Fund's:  (a) Articles of Incorporation and amendments
thereto; (2) minutes of the meetings of shareholders and Board of
Directors; (3) Notification of Registration on Form N-8A under the 1940
Act; (4) Registration Statement on Form N-1A under the Securities Act of
1933 ("1933 Act") and 1940 Act, and all amendments thereto; and (5) all
other relevant documents and records, as well as the procedures and
requirements relative to the issuance and sale of the Fund's shares of
common stock ("shares").

My examination also disclosed the following information:

The Fund is legally authorized to issue 1,000,000,000 shares with a $.001
par value.  On December 31, 1994, the Fund had 38,302,275 shares issued and
outstanding.

1.   On January 1, 1994, (the beginning of the Fund's last fiscal year), 
the Fund had no shares registered under the 1933 Act other than pursuant to
Rule 24f-2 of the 1940 Act, but which remained unsold on that date.

2.   During the fiscal year ended December 31, 1994, the Fund did not
register any shares under the 1933 Act other than pursuant to Rule 24f-2.

3.   During the fiscal year ended December 31, 1994, the Fund sold
12,877,090 shares at an aggregate sales price of $203,670,033 in reliance
upon registration pursuant to Rule 24f-2 of the 1940 Act.  During the same
fiscal year, the Fund redeemed 8,525,455 shares at an aggregate redemption
price of $133,522,914.

You have instructed me to file, on behalf of the Fund, a Notice pursuant to
Rule 24f-2 of the 1940 Act, for the purpose of registering, under the 1933
Act, the 12,877,090 shares which were sold by the Fund during the fiscal
year in reliance upon Rule 24f-2 of the 1940 Act.

Based upon the foregoing information and my examination, it is my opinion
that:

1.   The Fund is a validly organized and subsisting corporation of the
State of Maryland authorized to issue 1,000,000,000 shares, with a $.001
par value;



2.   The proposed registration of 12,877,090 shares of the Fund in reliance
upon Rule 24f-2 of the 1940 Act is proper;

3.   Such shares, which were issued for a consideration deemed by the Board
Directors to be consistent with the Articles of Incorporation , are legally
authorized and issued, fully paid and non-assessable; and

4.   The holders of such shares have the rights provided with respect to
such holdings by the Articles of Incorporation and the laws of the State of
Maryland.

I hereby consent to the use of this opinion as an Exhibit to the Rule 24f-2
Notice to be filed on behalf of the Fund, covering the registration of such
shares under the 1933 Act, and to the applications and registration
statements, and amendments thereto, filed in accordance with the securities
laws of the states in which shares of the Fund are offered.  I further
consent to the reference in the Prospectus of the Fund to the fact that
this opinion concerning the legality of the issue has been rendered by me. 

Very truly yours,




By:  (Raymond J. Klapinsky)






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