CHESAPEAKE BIOLOGICAL LABORATORIES INC
SC 13D, 2000-11-09
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D

                    Under the Securities Exchange Act of 1934
                               (Amendment No.   )*

                    Chesapeake Biological Laboratories, Inc.
                    ----------------------------------------
                                (Name of Issuer)

                 Class A common stock, par value $0.01 per share
                 -----------------------------------------------
                         (Title of Class of Securities)

                                     165146
                                     ------
                                 (CUSIP Number)

                                 Alex Glasenberg
                               Cangene Corporation
                               3403 American Drive
                                    Units 3/4
                              Mississauga, Ontario
                                 L4V 1T4, Canada

                            Telephone: (416) 749-9300
                                 ---------------
                  (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)

                                October 30, 2000
                                ----------------
             (Date of Event which Requires Filing of this Statement)

If the filing person has previously filed a statement on Schedule 13G to report
the acquisition that is the subject of this Schedule 13D, and is filing this
schedule because of (Section) 240.13d-1 (e), 240.13d-1 (f) or 240.13d-1 (g),
check the following box [ ].

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).


<PAGE>

CUSIP NO. 165146

1.     NAME OF REPORTING PERSON:    Cangene Corporation
       I.R.S. IDENTIFICATION NO. OF ABOVE PERSON:   N/A

2.     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP**
                           (a) [ ]          (b) [ ]

3.     SEC USE ONLY

4.     SOURCE OF FUNDS:   N/A

5.     CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
       PURSUANT TO ITEMS 2(d) OR 2(e)                                        [ ]

6.     CITIZENSHIP OR PLACE OF ORGANIZATION:
       Canada

       NUMBER OF         7.   SOLE VOTING POWER:
       SHARES                    0
       BENEFICIALLY      8.   SHARED VOTING POWER:
       OWNED BY                  1,811,998 (1)
       EACH              9.   SOLE DISPOSITIVE POWER:
       REPORTING                 0
       PERSON WITH       10.  SHARED DISPOSITIVE POWER:
                                 1,811,998 (1)

11.    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
       REPORTING PERSON:            1,811,988 (1)

12.    CHECK IF THE AGGREGATE AMOUNT IN ROW (11)
       EXCLUDES CERTAIN SHARES**

13.    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11):
          26 (2)

14.    TYPE OF REPORTING PERSON:   CO

(1)    The Reporting Person disclaims beneficial ownership of such shares and
       this Statement shall not be construed as an admission that the Reporting
       Person is the beneficial owner of any securities covered by this
       Statement.

(2)    Based on 5,681,156 shares outstanding at September 30, 2000, as
       represented by the Issuer in the Merger Agreement attached hereto as
       Exhibit A and treating the Convertible Preferred Stock (as defined below)
       as if converted.

                                       2
<PAGE>


CUSIP NO. 165146

1.     NAME OF REPORTING PERSON: AC Acquisition Subsidiary, Inc.
       I.R.S. IDENTIFICATION NO. OF ABOVE PERSON:   Applied For

2.     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP**
         (a) [ ]           (b) [ ]

3.     SEC USE ONLY

4.     SOURCE OF FUNDS:    N/A

5.     CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
       PURSUANT TO ITEMS 2(d) OR 2(e)                                        [ ]

6.     CITIZENSHIP OR PLACE OF ORGANIZATION:
         Maryland

         NUMBER OF         7.    SOLE VOTING POWER:
         SHARES                    0
         BENEFICIALLY      8.    SHARED VOTING POWER:
         OWNED BY                  1,811,998 (1)
         EACH              9.    SOLE DISPOSITIVE POWER :
         REPORTING                 0
         PERSON WITH       10.   SHARED DISPOSITIVE POWER:
                                   1,811,998 (1)

11.    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
       REPORTING PERSON:           1,811,998 (1)

12.    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11)
       EXCLUDES CERTAIN SHARES**

13.    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11):
       26 (2)

14.    TYPE OF REPORTING PERSON:      CO

(1)    The Reporting Person disclaims beneficial ownership of such shares and
       this Statement shall not be construed as an admission that the Reporting
       Person is the beneficial owner of any securities covered by this
       Statement.

(2)    Based on 5,681,156 shares outstanding at September 30, 2000, as
       represented by the Issuer in the Merger Agreement attached hereto as
       Exhibit A and treating the Convertible Preferred Stock as if converted.


                                       3
<PAGE>

This Statement is filed by Cangene Corporation ("Parent") and AC Acquisition
Subsidiary, Inc. ("Purchaser"), with the U.S. Securities and Exchange Commission
on November 9, 2000.


Item 1. Security and Issuer.
----------------------------

     This Statement relates to the Class A common stock, par value $0.01 per
share (the "Common Stock"), of Chesapeake Biological Laboratories, Inc. (the
"Company"). The Company's principal executive offices are located at 1111 South
Paca Street, Baltimore, Maryland 21230.

Item 2. Identity and Background.
--------------------------------

(a)-(c) This Statement is filed by Purchaser, a Maryland corporation, and
Parent, a Canadian corporation of which Purchaser is a wholly owned subsidiary.
Purchaser was formed solely for the purpose of acquiring all of the issued and
outstanding (i) shares of the Company's Common Stock (the "Shares"); (ii) shares
of the Company's Series A-1 Convertible Preferred Stock (the "Convertible
Preferred Stock"); and (iii) warrants to purchase Shares (the "Warrants"),
pursuant to a Merger Agreement, dated as of October 30, 2000, among Parent, the
Company and Purchaser, a copy of which is attached as Exhibit A hereto (the
"Merger Agreement"). Unless otherwise indicated, capitalized terms used but not
defined herein have the meanings ascribed to them in the Merger Agreement.

Purchaser has a principal place of business and principal office at c/o Harbor
City Research, Suite 630, 201 E. Baltimore Street, Baltimore, Maryland 21202,
and Parent has a principal place of business and principal office at 3403
American Drive, Units 3/4, Mississauga, Ontario, Canada L4V 1T4. For information
required by Instruction C to Schedule 13D with respect to each of Parent and
Purchaser, reference is made to Schedule I annexed hereto and incorporated
herein by reference.

(d)-(e) None of Parent, Purchaser, or to the best knowledge of either, any of
the persons listed on Schedule I hereto, has during the last five years (i) been
convicted in a criminal proceeding (excluding traffic violations or similar
misdemeanors) or (ii) been a party to any civil proceeding or a judicial or
administrative body of competent jurisdiction (except for matters that were
dismissed without sanction or settlement) that resulted in a judgment, decree or
final order enjoining him, her or it, as the case may be, from future violations
of, or prohibiting activities subject to, federal or state securities laws or
finding any violation of such laws.

Item 3. Source and Amount of Funds or Other Consideration.
----------------------------------------------------------

Pursuant to the Merger Agreement, subject to the terms and conditions therein,
Purchaser has agreed to (i) commence an offer (the "Offer") to purchase any and
all outstanding Shares at a price of $4.60 per Share (the "Per Share Amount")
and (ii) as soon as practicable after any requisite stockholders' meeting or
Purchaser's purchase and payment for shares of the capital stock of the Company
representing not less than ninety percent (90%) of the votes entitled to be cast
on the Merger pursuant to the Offer and the Company Option (as defined below),
consummate the Merger (as defined below). In the case of shares of Convertible
Preferred Stock


                                       4
<PAGE>

tendered pursuant to the Offer, Purchaser will pay the Per Share Amount
multiplied by the number of Shares into which such shares of Convertible
Preferred Stock are then convertible. In the case of Warrants tendered pursuant
to the Offer, Purchaser will purchase such Warrants for a purchase price equal
to the difference between the exercise price thereof and the Per Share Amount,
multiplied by the number of Shares for which such Warrants are then exercisable.
Holders of outstanding options to purchase Common Stock that have vested prior
to the Effective Time of the Merger, the exercise price of which is less than
the Per Share Amount will be entitled to receive an amount, without interest, in
cash paid at the Effective Time (as defined below) equal to the excess of the
Per Share Amount over the exercise price per share of the option, net of
applicable taxes, multiplied by the number of shares of Common Stock subject to
such option.

All funds necessary to consummate the Offer and the Merger are estimated to be
approximately $35 million. Such funds will be obtained from working capital of
Parent and from a line of credit to be obtained from Parent's bankers and will
be contributed to Purchaser prior to the Tender Offer Purchase Time.

In order to induce Parent and Purchaser to enter into the Merger Agreement and
to perform their obligations thereunder and as a condition thereof, the Company
has granted Purchaser an option (the "Company Option") to purchase from the
Company authorized but unissued shares of Series B Preferred Stock pursuant to
an option agreement substantially in the form attached as Exhibit C to this
Agreement (the "Option Agreement"); provided, however, that the exercise of the
Company Option shall be subject to the approval of the stockholders of the
Company if counsel to the Company reasonably determines that such approval is
required as a condition of the continued listing of the Shares on the Nasdaq
National Market at any time prior to Purchaser's exercise of the Company Option.
The Series B Preferred Stock is entitled to vote together with the Shares as a
single class on the Merger and any other matter to be voted upon by the Shares
and entitles each holder of the Series B Preferred Stock to 1,000 votes for each
share of Series B Preferred Stock held. The Option Agreement grants Purchaser
the right to purchase that number of shares of Series B Preferred Stock that
will cause Purchaser to own shares of the Company's capital stock representing
at least ninety percent (90%) of the total number of votes entitled to vote on
the Merger immediately following the exercise of the Company Option. The Company
Option is exercisable only when and if Purchaser has, pursuant to the Offer,
purchased and paid for at least a majority of the then issued and outstanding
Shares (giving effect to the conversion of all outstanding shares of Convertible
Preferred Stock and the exercise of all then outstanding Warrants) (the "Minimum
Condition"). The Company Option terminates and expires, if not previously
exercised, simultaneously with the earlier of (i) Purchaser's termination of the
Offer without having purchased and paid for a sufficient number of Shares to
satisfy the Minimum Condition or (ii) termination of the Merger Agreement. The
exercise price of the Company Option is $2,500,000 for all of the shares of
Series B Preferred Stock to be purchased.

In order to induce Parent and Purchaser to enter into the Merger Agreement and
to perform their obligations thereunder and as a condition thereof, certain
stockholders of the Company have entered into the Stockholders' Agreement
described in Item 6 of this Schedule 13D with respect to their Shares, shares of

                                       5
<PAGE>

Convertible Preferred Stock and/or Warrants. No Shares, shares of Convertible
Preferred Stock or Warrants were purchased by Parent or Purchaser pursuant to
the Stockholders' Agreement and thus no funds were used for such purpose.

Item 4. Purpose of Transaction.
-------------------------------

     (a)-(c) and (j) Parent, the Company and Purchaser have entered into the
Merger Agreement, pursuant to which Purchaser will offer (the "Offer") to
purchase (i) the Shares, at the Per Share Amount; (ii) the Convertible Preferred
Stock, at the Per Share Amount multiplied by the number of Shares into which
such shares of Convertible Preferred Stock are then convertible; and (iii) the
Warrants, for a purchase price equal to the difference between the exercise
price thereof and the Per Share Amount, multiplied by the number of Shares for
which such Warrants are then exercisable. All such amounts shall be paid net to
each seller in cash, less any required withholding of taxes. The Merger
Agreement provides that Purchaser will be merged with and into the Company (the
"Merger") as soon as practicable following any requisite stockholders' meeting
or Purchaser's purchase and payment for shares of the capital stock of the
Company representing not less than ninety percent (90%) of the votes entitled to
be cast on the Merger pursuant to the Offer and the Company Option. Following
the Merger, the Company will continue as the surviving corporation (the
"Surviving Corporation") and a wholly owned subsidiary of Parent, and the
separate corporate existence of Purchaser will cease. Pursuant to the Merger
Agreement, each Share issued and outstanding immediately prior to the effective
time of the Merger (the "Effective Time") (other than (i) Shares held by any of
the Company's subsidiaries and (ii) Shares held by Parent, Purchaser or any
other subsidiary of Parent), will be converted into and shall become the right
to receive the Per Share Amount in cash, without interest. At the Effective
Time, each share of Convertible Preferred Stock issued and outstanding
immediately prior to the Effective Time (excluding (i) any shares of Convertible
Preferred Stock held by any of the Company's subsidiaries and (ii) any shares of
Convertible Preferred Stock held by Parent, Purchaser or any other subsidiary of
Parent) will be converted into and shall become the right to receive the Per
Share Amount multiplied by the number of Shares into which such share of
Convertible Preferred Stock is then convertible. At the Effective Time, any
outstanding Company options (other than stock options granted by the Company to
employees, directors, officers or consultants), warrants, convertible preferred
stock (other than the Convertible Preferred Stock and the Series B Preferred
Stock) or other securities that are convertible into, exercisable for or
exchangeable for Shares and by their terms are not automatically converted into,
exercised for or exchanged for the right to receive the Per Share Amount as a
result of the Merger shall represent only the right to receive the Per Share
Amount (minus any cash exercise or exchange price). The foregoing summary of
certain provisions of the Merger Agreement is qualified in its entirety by
reference to the text of the Merger Agreement.

The purpose of the Offer is to acquire control of, and the entire equity
interest in, the Company. The purpose of the Merger is to acquire all
outstanding Shares, shares of Convertible Preferred Stock and Warrants not
tendered and purchased pursuant to the Offer. If the Offer is successful,
Purchaser intends to consummate the Merger as soon as practicable following the
satisfaction or waiver of each of the conditions to the Merger set forth in the
Merger Agreement.

Except as described in the Merger Agreement and in this Item 4, neither Parent
nor Purchaser has

                                       6
<PAGE>

any present plans or proposals that would relate to or result in (i) the
acquisition by any person of additional securities of the Company or the
disposition of securities of the Company; (ii) an extraordinary corporate
transaction, such as a merger, reorganization or liquidation involving the
Company or any of its subsidiaries; (iii) a sale or transfer of a material
amount of assets of the Company or any of its subsidiaries; (iv) any change in
the Board of Directors of the Company (the "Company Board") or management of the
Company; (v) any material change in the present capitalization or dividend
policy of the Company; (vi) any other material change in the Company's business
or corporate structure; (vii) changes in the charter, bylaws or instruments
corresponding thereto or other actions that might impede the acquisition of
control of the Company by any person; (viii) causing a class of securities of
the Company to be delisted from a national securities exchange or to cease to be
authorized to be quoted in an inter-dealer quotation system of a registered
national securities association; or (ix) a class of equity securities of the
Company becoming eligible for termination of registration pursuant to Section
12(g)(4) of the Securities Exchange Act of 1934 (the "Act").

(d) The Merger Agreement provides that promptly after the Tender Offer Purchase
Time, and from time to time thereafter, Purchaser shall be entitled to designate
that number (but no more than that number) of directors of the Company
constituting a majority of the Company Board, and the Company will use its best
efforts to, upon request by Purchaser, promptly, at the Company's election,
either increase the size of the Company Board or secure the resignation of such
number of directors as is necessary to enable Purchaser's designees to be
elected to the Company Board and to cause Purchaser's designees to be so elected
and to constitute at all times after the Tender Offer Purchase Time a majority
of the Company Board. At such times, the Company will use its best efforts to
cause persons designated by Purchaser to constitute the same percentage as is on
the Company Board of (i) each committee of the Company Board (other than any
committee of the Company Board established to take action under the Merger
Agreement), (ii) each board of directors of each subsidiary of the Company and
(iii) each committee of each such board. Notwithstanding the foregoing, until
the Effective Time, the Company shall retain at least three directors who are
directors of the Company on the date of the Merger Agreement.

The Company's obligation to appoint designees to the Board is subject to Section
14(f) of the Act and Rule 14f-1 promulgated thereunder.

The directors of Purchaser at the Effective Time will be the initial directors
of the Surviving Corporation and will hold office in accordance with the
Articles of Incorporation and Bylaws of the Surviving Corporation until the next
annual meeting of stockholders and until their respective successors are duly
elected or appointed and qualified; provided, however, that immediately
following the Merger, the Board of Directors of the Surviving Corporation will
cause Thomas P. Rice to be appointed a director of the Surviving Corporation.
The officers of the Company at the Effective Time will be the initial officers
of the Surviving Corporation and will hold office in accordance with the
Articles of Incorporation and Bylaws of the Surviving Corporation until their
respective successors are duly elected or appointed and qualified.

(e) Pursuant to the Merger Agreement, the Company has agreed that, prior to the
consummation of the Merger, unless Parent shall otherwise agree in writing or as
otherwise

                                       7
<PAGE>

contemplated in the Merger Agreement, the Company will not declare, set aside or
pay any dividends on, or make other distributions in respect of any of the
Company's stock, except that the Company may pay an aggregate dividend of
$43,533.00 on the Convertible Preferred Stock on November 12, 2000.

(f) It is expected that, initially following the Merger, the business operations
of the Company will be continued by the Surviving Corporation substantially as
they are currently being conducted. Upon completion of the Offer and the Merger,
Parent intends to conduct a detailed review of the Company and its assets,
corporate structure, capitalization, operations, policies, management and
personnel. After such review, Parent will determine what actions or changes, if
any, would be desirable in light of the circumstances which then exist.

(g) The Articles of Incorporation of Purchaser in effect at the Effective Time
will be the Articles of Incorporation of the Surviving Corporation until amended
in accordance with applicable law. The Bylaws of Purchaser in effect at the
Effective Time will be the Bylaws of the Surviving Corporation until amended in
accordance with applicable law.

(h) It is Parent's current intention to cause the Company to terminate the
inclusion of the Shares on the Nasdaq National Market following the Tender Offer
Purchase Time and as soon as the number of holders of record of the Shares is
fewer than 300. Inclusion of the Shares on the Nasdaq National Market is
voluntary, so the Company may terminate that inclusion at any time. In addition,
depending upon the number of Shares purchased pursuant to the Offer, the Shares
may no longer meet the standards for continued inclusion in the Nasdaq National
Market.

(i) The Shares are currently registered under the Act. The purchase of the
Shares pursuant to the Offer may result in the Shares becoming eligible for
deregistration under the Act. Pursuant to the Merger Agreement, the Company has
agreed, at the earliest practicable time following the Tender Offer Purchase
Time and as soon as the number of holders of record of the Shares is fewer than
300, to take all steps necessary or appropriate to terminate registration of the
Shares under the Act, including without limitation the filing of Form 15 under
the Act with the Securities and Exchange Commission and of a notice to the
Nasdaq National Market to delist the Shares.

Item 5. Interest in Securities of the Issuer.
---------------------------------------------

(a)-(b) Each of Parent and Purchaser may be deemed to have beneficial ownership
of, and shared voting and disposition power with respect to, an aggregate of
1,811,998 Shares, which constitutes approximately 26% of the 5,681,156 Shares of
the Company issued and outstanding as of September 30, 2000 (based on the
Company' representation of its capitalization in the Merger Agreement and
treating the Convertible Preferred Stock as if converted).

Each of Parent and Purchaser may be deemed to have beneficial ownership of, and
shared voting and disposition power with respect to, these Shares pursuant to
the Stockholders' Agreement,

                                       8
<PAGE>

pursuant to which each Stockholder has granted to Purchaser or its designee,
effective on the date of the Stockholders' Agreement, an irrevocable proxy (see
Item 6.) and an irrevocable option (each, an "Option") to purchase all Company
Securities Beneficially Owned (as those terms are defined in the Stockholders'
Agreement) by such Stockholder at a purchase price equal to (i) in the case of
Shares, the Per Share Amount per Share; (ii) in the case of shares of
Convertible Preferred Stock, the Per Share Amount multiplied by the number of
Shares into which such shares of Convertible Preferred Stock are convertible;
and (iii) in the case of Warrants, the difference between the exercise price
thereof and the Per Share Amount, multiplied by the number of Shares for which
such Warrants are then exercisable. Purchaser may exercise the Options at any
time following the occurrence of a Purchase Event (as defined in the
Stockholders' Agreement). The Options will expire and be of no further force and
effect upon the earliest to occur of (i) the Tender Offer Purchase Time, (ii) at
the close of business on the third business day after the receipt by Parent of a
Superior Proposal Notice or (iii) the 60th day after the exercise of the
Options, if the purchase of the Company Securities pursuant to the Options has
not occurred. The purchase of Shares pursuant to the Options is subject to the
satisfaction of the following conditions: (i) to the extent necessary, all
waiting periods under the Hart-Scott-Rodino Antitrust Improvements Act of 1976
(the "HSR Act") applicable to the acquisition of the Shares shall have been
terminated or have expired and any other approvals, notices, authorizations or
consents shall have been filed or obtained; (ii) no preliminary or permanent
injunction prohibiting the exercise of the Options or delivery of the Shares
shall be in effect and (iii) Purchaser's loan commitment shall not have been
withdrawn by its lender.

The Company has granted Purchaser the Company Option. See Item 3.

Each of Parent and Purchaser, however, hereby disclaims beneficial ownership of
such Shares, and this Statement shall not be construed as an admission that
either Parent or Purchaser is, for any or all purposes, the beneficial owner of
the securities covered by this Statement. Other than as provided in the first
sentence of this Item 5, none of Parent, Purchaser or to the best knowledge of
either, any of the persons listed on Schedule I hereto, owns or has any right to
acquire, directly or indirectly, the Shares.

(c) Except pursuant to the Merger Agreement, the Stockholders' Agreement and the
Company Option, none of Parent, Purchaser or, to the best knowledge of either,
any of the persons listed on Schedule I hereto, has effected any transaction in
the Shares during the past 60 days.

(d) Until Purchaser's exercise of the Options, each Stockholder will have the
right to receive dividends from, and the proceeds from the sale, subject to
certain restrictions on transferability imposed under the Stockholders'
Agreement, of such Stockholders' Company Securities.

(e) Not applicable.


                                       9
<PAGE>


Item 6. Contracts, Arrangements, Understandings or Relationships with Respect to
--------------------------------------------------------------------------------
Securities of the Issuer.
-------------------------


Concurrently with the execution of the Merger Agreement, Parent, Purchaser and
the Stockholders have entered into the Stockholders' Agreement. The following
summary of certain provisions of the Stockholders' Agreement, which is filed as
Exhibit B hereto, is qualified in its entirety by reference to the text of the
Stockholders' Agreement. Capitalized terms used in this Item 6 but not otherwise
defined in this Item 6 or in the Merger Agreement have the meanings ascribed to
them in the Stockholders' Agreement.

Pursuant to the Stockholders' Agreement, each Stockholder has agreed to tender
the Company Securities owned by such Stockholder into the Offer promptly after
Parent causes Purchaser to commence the Offer, but in no event later than five
business days after the date on which the Stockholder receives the offer to
purchase and related letter of transmittal for tendering such Company
Securities. Each Stockholder has further agreed not to withdraw any Company
Securities so tendered unless and until after the Termination Date.

Each Stockholder has further agreed that, during the period commencing on the
date of the Stockholders' Agreement and continuing until the first to occur of
the Effective Time or the Termination Date, the Stockholder will vote (or cause
to be voted) its Company Securities entitled to vote (i) in favor of approval of
the Merger Agreement, all transactions contemplated thereby, and any actions
required in furtherance thereof; (ii) against any action or agreement that is
intended to or could impede, interfere with, or prevent the Offer or the Merger
or result in a breach in any respect of any covenant, representation or warranty
or any other obligation or agreement of the Company or any of its subsidiaries
under the Merger Agreement or the Stockholders' Agreement; and (iii) except as
specifically requested in writing in advance by Parent, against certain actions
specified in the Stockholders' Agreement, including extraordinary corporate
transactions, dispositions of assets outside the ordinary course of business,
any reorganization, recapitalization, dissolution or liquidation of the Company
or any of its subsidiaries or affiliates, and any amendment of the Company's
Articles of Incorporation or Bylaws.

In order to secure their respective obligations under the Stockholders'
Agreement, each Stockholder has granted to John Langstaff and Alex Glasenberg,
in their respective capacities as officers of Parent, and any individual who
shall hereafter succeed to any such office of Parent, and any other designee of
Parent, an irrevocable proxy to vote the Stockholder' Company Securities
entitled to vote, or grant a consent or approval in respect of the Stockholder's
Company Securities, with respect to the matters described above on which the
Company Securities are entitled to vote from the date that all waiting periods
under the HSR Act applicable to the acquisition of the Shares have been
terminated or have expired and any other required approvals, notices,
authorizations or consents have been filed or obtained, and until the
Termination Date.

In addition, each Stockholder has agreed not to (i) tender its Company
Securities in any tender offer or exchange offer for the Company Securities
other than the Offer; (ii) sell, transfer, tender, pledge, encumber, assign or
otherwise dispose of, or enter into any contract for the sale, transfer, tender,
pledge, encumbrance, assignment or other disposition of, any or all of its
Company Securities; (iii) except as contemplated by the Stockholders' Agreement,
grant any proxies or

                                       10
<PAGE>

powers of attorney, deposit any of its Company Securities into a voting trust or
enter into a voting agreement with respect to any Company Securities; or (iv)
take any action that would make any representation or warranty of the
Stockholder untrue or incorrect or have the effect of preventing or impairing
such Stockholder from performing its obligations under the Stockholders'
Agreement.

The Company has granted Purchaser the Company Option. See Item 3.

Item 7. Material to be Filed as Exhibits.
-----------------------------------------

     Exhibit A    Merger Agreement, dated as of October 30, 2000, among Parent,
                  the Company and Purchaser.

     Exhibit B    Stockholders' Agreement, dated as of October 30, 2000, by and
                  among Parent, Purchaser and the stockholders of the Company
                  listed on Schedule I thereto.

     Exhibit C    Option Agreement, dated as of October 30, 2000, by and between
                  the Company and Purchaser.








                                       11
<PAGE>

                                    SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.


November 9, 2000



                               CANGENE CORPORATION
                               By: /s/ Alex Glasenberg
                                   -------------------
                                   Alex Glasenberg
                                   Chief Financial Officer












                                       12
<PAGE>

                                    SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.

November 9, 2000



                         AC ACQUISITION SUBSIDIARY, INC.
                         By: /s/ Alex Glasenberg
                             -------------------
                             Alex Glasenberg
                             Vice President














                                       13
<PAGE>

                                  EXHIBIT INDEX

Exhibit A           Merger Agreement, dated as of October 30, 2000, among
                    Parent, the Company and Purchaser.

Exhibit B           Stockholders' Agreement, dated as of October 30, 2000, by
                    and among Parent, Purchaser and the stockholders of the
                    Company listed on Schedule I thereto.

Exhibit C           Option Agreement, dated as of October 30, 2000, by and
                    between the Company and Purchaser.














                                       14
<PAGE>

                                   SCHEDULE I

            DIRECTORS AND EXECUTIVE OFFICERS OF PARENT AND PURCHASER

1.   DIRECTORS AND EXECUTIVE OFFICERS OF PARENT

     The following table sets forth the name and present principal occupation or
employment, and the name, principal business and address of any corporation or
other organization in which such occupation or employment is conducted of each
director and executive officer of Parent. Unless otherwise indicated, the
business address of each such person is c/o Parent at 3403 American Drive, Units
3/4, Mississauga, Ontario, Canada, L4V 1T4 and each such person is a citizen of
Canada.

DIRECTORS                 PRESENT PRINCIPAL OCCUPATION
---------                 ----------------------------

R. Craig Baxter           President, Apotex International, Inc.
                          Executive Vice President, Apotex Inc.
                          150 Signet Drive
                          Weston, Ontario
                          M9L 1T9
                          Canada

Alex Glasenberg           Vice President-Finance, Apotex Inc.
                          150 Signet Drive
                          Weston, Ontario
                          M9L 1T9
                          Canada

Jack M. Kay               President and Chief Operating Officer, Apotex Inc.
                          150 Signet Drive
                          Weston, Ontario
                          M9L 1T9
                          Canada

John Langstaff            President and Chief Executive Officer, Cangene
                            Corporation
                          104 Chancellor-Matheson Road
                          Winnipeg, Manitoba
                          R3T 2N2
                          Canada

John Nystrom              Vice President and Chief Technical Officer, The
                            Medicines Company
                          One Cambridge Center
                          Cambridge Massachusetts  02142
                          USA



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<PAGE>

Bernard C. Sherman        Chairman and Chief Executive Officer, Apotex Inc.
                          150 Signet Drive
                          Weston, Ontario
                          M9L 1T9
                          Canada

Michael Spino             Senior Vice President-Scientific Affairs,
                          Apotex Inc.
                          150 Signet Drive
                          Weston, Ontario
                          M9L 1T9
                          Canada

Richard W. Taylor         Consultant, The Lesley Company Inc.
                          Health Sector Consulting
                          31 Felbrigg Avenue
                          Toronto, Ontario
                          M5M 2L8


EXECUTIVE OFFICERS        PRESENT EMPLOYMENT
------------------        ------------------

William Labossiere Bees   Vice President, Operations

Alex Glasenberg           Chief Financial Officer

Wendy Johnson             Vice President, Research & Development

John Langstaff            President and Chief Executive Officer

John W. McMillan          General Manager

Andrew D. Storey          Vice President, Quality Assurance/Clinical &
                            Regulatory Affairs

2.   DIRECTORS AND EXECUTIVE OFFICERS OF PURCHASER

     The following table sets forth the name and present principal occupation or
employment, and the name, principal business and address of any corporation or
other organization in which such occupation or employment is conducted of each
director and executive officer of Purchaser. Unless otherwise indicated below,
each occupation set forth opposite each person refers to employment with
Purchaser. The business address of each such person is c/o Parent at 3403
American Drive, Units 3/4, Mississauga, Ontario, Canada, L4V 1T4 and each such
person is a citizen of Canada.


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<PAGE>

DIRECTORS AND
EXECUTIVE OFFICERS      PRINCIPAL OCCUPATION
------------------      --------------------

Alex Glasenberg         Vice President-Finance, Apotex Inc.

John Langstaff          President and Chief Executive Officer, Cangene
                          Corporation

John W. McMillan        General Manager, Cangene Corporation







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