EPITOPE INC/OR/
8-K, 1996-10-11
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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<PAGE>

                      SECURITIES AND EXCHANGE COMMISSION

                            Washington, D.C.  20549

                               _________________

                                   FORM 8-K

                                CURRENT REPORT

                      Pursuant to Section 13 or 15(d) of
                      the Securities Exchange Act of 1934

               Date of Report (Date of earliest event reported):

                              September 17, 1996

                               _________________


                                 EPITOPE, INC.
              (Exact name of Registrant as specified in charter)

                                    Oregon
                (State or other jurisdiction of incorporation)

                                    1-10492
                             (Commission File No.)

                                  93-0779127
                       (IRS Employer Identification No.)

    8505 S.W. Creekside Place
        Beaverton, Oregon                           97008
(Address of principal executive offices)          (Zip Code)

              Registrant's telephone number, including area code:

                                (503) 641-6115

<PAGE>
Item 5.   Other Events.

          On September 17, 1996, Epitope, Inc. issued a press release
regarding recent events of interest to shareholders.  A copy of the press
release is attached as an exhibit to this report.

Item 7.   Financial Statements, Pro Forma Financial Information and Exhibits.

          (a)   Not applicable.

          (b)   Not applicable.

          (c)   Exhibits.

          The exhibits filed herewith are listed in the exhibit index
following the signature page of this report.

<PAGE>
                                  SIGNATURES

          Pursuant to the requirements of the Securities Exchange Act of
1934, the Registrant has duly caused this report to be signed on its behalf by
the undersigned hereunto duly authorized.

                                  EPITOPE, INC.


Dated:  October 11, 1996    By:   
                                  Gilbert N. Miller
                                  Executive Vice President and Chief
                                  Financial Officer
<PAGE>
                                 EXHIBIT INDEX


4.1       Notice to warrantholders and current form of warrant certificate
          for warrants issued in September 1991 offering, reflecting
          extension of expiration date.

4.2       Notice to warrantholders and current form of warrant certificate
          for warrants issued in December 1992 offering, reflecting extension
          of expiration date.

4.3       Notice to warrantholders and current form of warrant certificate
          for warrants issued in July 1993 offering, reflecting extension of
          expiration date.

4.4       Notice to warrantholders and current form of warrant certificate
          for warrants issued in August 1993 offering, reflecting extension
          of expiration date.

99.1      Press release of Epitope, Inc., dated September 17, 1996.
<PAGE>


<PAGE>
                                                                   Exhibit 4.1
                       [Form of Notice -- 1991 Warrants]

                           NOTICE TO WARRANTHOLDERS
                                   REGARDING
                         EXTENSION OF EXPIRATION DATE

THE WARRANTS REFERRED TO BELOW AND THE SHARES OF COMMON STOCK UNDERLYING THE
WARRANTS HAVE NOT BEEN REGISTERED FOR ISSUANCE TO THE WARRANTHOLDERS UNDER THE
UNITED STATES SECURITIES ACT OF 1933, AS AMENDED ("1933 ACT"), AND MAY NOT BE
OFFERED, SOLD, TRANSFERRED, PLEDGED, OR OTHERWISE DISPOSED OF, IN WHOLE OR IN
PART, DIRECTLY OR INDIRECTLY, IN THE UNITED STATES OR TO A U. S. PERSON (AS
SUCH TERMS ARE DEFINED IN REGULATION S UNDER THE 1933 ACT), NOR MAY THE
WARRANTS BE EXERCISED IN THE UNITED STATES OR BY OR ON BEHALF OF A U. S.
PERSON, UNLESS (i) THE TRANSACTION IS REGISTERED UNDER THE 1933 ACT AND ANY
APPLICABLE SECURITIES LAWS OF ANY STATE, TERRITORY OR POSSESSION OF THE UNITED
STATES OR THE DISTRICT OF COLUMBIA ("STATE ACT"), OR (ii) AN EXEMPTION FROM
REGISTRATION UNDER THE 1933 ACT OR ANY APPLICABLE STATE ACT IS AVAILABLE AND
THE ISSUER HAS RECEIVED AN OPINION OF COUNSEL TO SUCH EFFECT REASONABLY
SATISFACTORY TO IT.

[Name and Address of Warrantholder]

          Reference is made to the warrants ("Warrants") to purchase common
stock, no par value ("Common Stock"), of Epitope, Inc. (the "Company")
originally issued by the Company on September 26, 1991, and the related
Warrant Agreements ("Warrant Agreements") dated as of the same date containing
the terms of the Warrants.  Capitalized terms used and not otherwise defined
herein have the same meanings as in the Warrant Agreements.

          The Expiration Date for the Warrants is September 25, 1996.  The
Company hereby extends the Expiration Date until September 30, 1997, and will
permit all Warrantholders to exercise Warrants through that date.

          Please attach a copy of this notice to your Warrant Agreement.


Dated:  September ___, 1996.


                                    EPITOPE, INC.


                                    By 
                                        ---------------------------------
                                       President
<PAGE>
THESE WARRANTS AND THE SHARES OF COMMON STOCK UNDERLYING THESE WARRANTS MAY
NOT BE OFFERED, SOLD, TRANSFERRED, PLEDGED OR OTHERWISE DISPOSED OF, IN WHOLE
OR IN PART, DIRECTLY OR INDIRECTLY, IN THE UNITED STATES OR TO A U.S. PERSON
(AS SUCH TERMS ARE DEFINED IN REGULATION S UNDER THE SECURITIES ACT OF 1933,
AS AMENDED, OF THE UNITED STATES OF AMERICA (THE "1933 ACT")), NOR MAY THESE
WARRANTS BE EXERCISED IN THE UNITED STATES OR BY OR ON BEHALF OF A U.S.
PERSON, UNLESS (i) THE TRANSACTION IS REGISTERED UNDER THE 1933 ACT AND ANY
APPLICABLE SECURITIES LAWS OF ANY STATE, TERRITORY OR POSSESSION OF THE UNITED
STATES OF AMERICA OR THE DISTRICT OF COLUMBIA ("STATE ACT"), OR (ii) AN
EXEMPTION FROM REGISTRATION UNDER THE 1933 ACT OR ANY APPLICABLE STATE ACT IS
AVAILABLE AND THE ISSUER HAS RECEIVED AN OPINION OF COUNSEL TO SUCH EFFECT
REASONABLY SATISFACTORY TO IT. 


            VOID AFTER 5 P.M., PACIFIC TIME, ON SEPTEMBER 30, 1997,
                       WARRANTS TO PURCHASE COMMON STOCK

                         [Number of warrants] Warrants


                                 EPITOPE, INC.

                              THIS CERTIFIES THAT

                            [Name of warrantholder]

or registered assigns, is the registered holder of the number of Warrants
("Warrants") set forth above.  Each Warrant entitles the holder thereof (the
"Warrantholder") to purchase from Epitope, Inc., a corporation incorporated
under the laws of the state of Oregon ("Company"), United States of America,
one fully paid and nonassessable share of common stock, no par value, of the
Company ("Common Stock") upon presentation and surrender of this Warrant
Agreement with the instructions for the registration and delivery of Common
Stock filled in, at any time prior to 5 P.M., Pacific time, on ________ __,
1996, at the corporate offices of the Company at 8505 S.W. Creekside Place,
Beaverton, Oregon 97008, United States of America, or at such other address as
may be specified by the Company pursuant to Section 9, accompanied by payment
of the Exercise Price (as defined herein) and any applicable taxes, either in
cash or by certified or official bank check, payable in lawful money of the
United States of America to the order of the Company.
<PAGE>
      Section 1.  Exercise Price.  Each Warrant entitles the Warrantholder to
purchase one share of Common Stock for U.S. $16.00 (the "Exercise Price"),
subject to adjustment as provided herein.

      Section 2.  Expiration.  All Warrants not theretofore exercised shall
expire at 5 p.m., Pacific time, on September 30, 1997 (the "Expiration Date").

      Section 3.  Adjustments of Number and Kind of Shares Purchasable and
Exercise Price.  The number and kind of securities or other property
purchasable upon exercise of a Warrant shall be subject to adjustment from
time to time upon the occurrence, after the date hereof, of the following
events:

            3.1  If the outstanding shares of the Company's Common Stock
      are divided into a greater number of shares or a dividend in stock
      is paid on the Common Stock, the number of shares of Common Stock
      issuable on exercise of the Warrants shall be proportionately
      increased and the Exercise Price in effect immediately prior to
      such subdivision or at the record date of such dividend shall,
      simultaneously with the effectiveness of such subdivision or
      immediately after the record date of such dividend, be
      proportionately reduced; and, conversely, if the outstanding
      shares of Common Stock are combined into a smaller number of
      shares of Common Stock, the number of shares of Common Stock
      issuable upon exercise of the Warrants shall be proportionately
      reduced and the Exercise Price in effect immediately prior to such
      combination shall, simultaneously with the effectiveness of such
      combination, be proportionately increased.  The increases and
      reductions provided for in this subsection 3.1 shall be made with
      the intent and, as nearly as practicable, the effect that neither
      the percentage of the total equity of the Company issuable on
      exercise of the Warrants nor the price payable for such percentage
      upon such exercise shall be affected by any event described in
      this subsection 3.1.

            3.2  No adjustment of the Exercise Price will be made if the
      amount of the adjustment is less than one cent per share, but in
      that case any adjustment that would otherwise be required to be
      made will be carried forward and will be made at the time of and
      together with the next adjustment of the Exercise Price which,
      together with any adjustment carried forward, amounts to one cent
      per share or more.

            3.3  In case of any change in the Common Stock of the
      Company through merger, consolidation, reclassification,
      reorganization, partial or complete liquidation, or other change
      in the capital structure of the Company (not including a
      combination of shares or the issuance of additional shares of
      Common Stock by the Company by stock split or stock dividend),
      then, as a condition of the change in the capital structure of the
      Company, provision shall be made so that the holder of this
      Warrant Agreement will have the right thereafter to receive upon
      the exercise of the Warrants the kind and amount of shares of
      stock or other securities or property to which such holder would
      have been entitled if, immediately prior to such merger,
      consolidation, reclassification, reorganization, recapitalization,
      or other change in the capital structure, such holder had held the
      number of shares of Common Stock issuable upon the exercise of the
      Warrants.  In any such case, appropriate adjustment shall be made
      in the application of the provisions set forth herein with respect
      to the rights and interest thereafter of the Warrantholder, to the
      end that the provisions set forth herein shall thereafter be
      applicable, as nearly as reasonably may be, in relation to any
      shares of stock or other property thereafter deliverable upon the
      exercise of the Warrants.  The Company will not permit any change
      in its capital structure to occur unless the issuer of the shares
      of stock or other securities to be received by the holder of this
      Warrant Agreement, if not the Company, agrees to be bound by and
      comply with the provisions of this Warrant Agreement.

            3.4  When any adjustment is required to be made in the
      number of shares of Common Stock, other securities, or the
      property purchasable upon exercise of the Warrants, the Company
      shall promptly determine the new number of shares or other
      securities or property purchasable upon exercise of the Warrants
      and (i) prepare and retain on file a statement describing in
      reasonable detail the method used in arriving at the new number of
      shares or other securities or property purchasable upon exercise
      of the Warrants and (ii) cause a copy of such statement to be
      mailed to the Warrantholder within thirty (30) days after the date
      when the event giving rise to the adjustment occurred.

            3.5  No fractional shares of Common Stock or other
      securities will be issued in connection with the exercise of any
      Warrants, but the Company shall pay, in lieu of fractional shares,
      a cash payment therefor on the basis of the closing price on a
      national securities exchange on the day immediately prior to
      exercise or if the Common Stock or other securities are not traded
      on a national securities exchange on such day, on the basis of the
      fair market value thereof as determined by the board of directors
      of the Company, which determination shall be conclusive.

            3.6  Notwithstanding anything herein to the contrary, there
      shall be no adjustment made hereunder on account of the sale and
      issuance of the shares of Common Stock or other securities
      purchasable upon exercise of the Warrants.

      Section 4.  Rights of Warrantholder as Shareholder.  No holder of this
Warrant Agreement shall, as such, be entitled to vote, receive dividends, or
be deemed the holder of Common Stock or any other securities of the Company
that may at any time be issuable on the exercise hereof for any purpose
whatever, nor shall anything contained herein be construed to confer upon the
holder of this Warrant Agreement, as such, any of the rights of a shareholder
of the Company or any right to vote for the election of directors or upon any
matter submitted to shareholders at any meeting thereof or give or withhold
consent to any corporate action (whether upon any matter submitted to
shareholders at any meeting thereof or otherwise) including, without
limitation, giving or withholding consent to any merger, recapitalization,
issuance of stock, reclassification of stock, change of par value or change of
stock to no par value, consolidation or conveyance, or to receive notice of
meetings or other actions affecting shareholders or to receive dividends or
subscription rights or other distributions.

      Section 5.  Payment of Certain Taxes and Charges.  The Company shall not
be required to issue or deliver any certificate for shares of Common Stock or
other securities upon the exercise of Warrants evidenced by this Warrant
Agreement or to register the transfer of the Warrants evidenced hereby until
any applicable transfer tax and any other taxes or governmental charges that
the Company may be required by law to collect in respect of such exercise or
transfer shall have been paid, such tax being payable by the holder of this
Warrant Agreement at the time of surrender for exercise or transfer.

      Section 6.  Registration.  

            6.1   Registration Statement.  The Company has prepared a
      registration statement on Form S-3 (the "Registration Statement")
      under the 1933 Act with respect to transfer by the Warrantholder
      of the Warrants covered by this Warrant Agreement and the re-sale
      by the Warrantholder of the shares of Common Stock issued or
      issuable upon exercise of this Warrant Agreement (the "Warrant
      Shares").  A soon as practicable after the original issue date of
      this Warrant Agreement (the "Original Issue Date"), the Company
      shall file the Registration Statement with the United States
      Securities and Exchange Commission and shall use its best efforts
      to cause the Registration Statement to become effective under the
      1933 Act as promptly as practicable after the Original Issue Date. 
      If required by applicable law, the Company shall furnish to the
      initial Warrantholder such reasonable number of copies of a
      prospectus, in conformity with the requirements of the 1933 Act,
      and any amendments or supplements thereto and such other documents
      as such Warrantholder may reasonably request in order to
      facilitate the disposition of the Warrants and Warrant Shares (the
      "Securities") after the Registration Statement has been declared
      effective.  The Company shall use reasonable efforts (i) to notify
      the initial Warrantholder when a prospectus relating to the
      Securities is required to be delivered under the 1933 Act, (ii) to
      notify the initial Warrantholder of the happening of any event as
      a result of which the prospectus included in the Registration
      Statement, as then in effect, includes an untrue statement of a
      material fact or omits to state a material fact required to be
      stated therein or necessary to make the statements therein not
      misleading in the light of the circumstances then existing, (iii)
      to promptly file such amendments and supplements as may be
      required on account of such event, and (iv) to use its best
      efforts to cause each such amendment and supplement to become
      effective.  The initial Warrantholder shall not effect sales of
      the Securities after receipt of notice from the Company that any
      such amendment or supplement is required on account of any such
      event, until the amendment or supplement becomes effective.  The
      Company's obligations under this Section 6.1 shall expire five
      years after the Original Issue Date or on any earlier date by
      which the initial Warrantholder has sold the Securities or on and
      after which the initial Warrantholder may sell the Securities
      without registration under the 1933 Act.

            6.2   Warrantholder Information.  It shall be a condition
      precedent to the obligations of the Company to take any action
      pursuant to this Section 6 that Warrantholder shall furnish to the
      Company such information regarding itself, the Securities, and the
      intended method of disposition of the Securities as the Company
      shall reasonably request.

            6.3   Expenses of Registration.  The Company shall pay all
      expenses (other than underwriting discounts and commissions,
      transfer taxes, if any, and fees and disbursements of counsel to
      the Warrantholder) incurred in connection with the Registration
      Statement.

      Section 7.  Transfer and Exchange.

            7.1   Transfer.  This Warrant Agreement is transferable on
      the registry books of the Company subject to the restrictions on
      the first page hereof and in Section 7.4.  The Company may deem
      and treat the person in whose name this Warrant Agreement is
      registered as the absolute owner hereof (notwithstanding any
      notation of ownership or other writing thereon made by anyone
      other than the Company) for all purposes whatever, and the Company
      shall not be affected by any notice to the contrary.

            7.2   Exchange.  Subject to the provisions of Section 7.4,
      this Warrant Agreement is exchangeable at the principal office of
      the Company for Warrant Agreements to purchase the same aggregate
      number of shares of Common Stock as are purchasable hereunder,
      each new Warrant Agreement to represent the right to purchase such
      number of shares as the Warrantholder shall designate at the time
      of such exchange.

            7.3   Securities Act of 1933.  The Warrantholder, by
      acceptance hereof, agrees that this Warrant Agreement and the
      shares of Common Stock issued or issuable upon exercise of this
      Warrant Agreement may not be offered or sold except in compliance
      with the 1933 Act.  The Warrantholder consents to the Company's
      making a notation on its records and on the certificates for any
      shares of Common Stock issued upon exercise hereof in order to
      implement such restriction on transferability.

            7.4   Minimum Warrant Agreement Amount.  Notwithstanding the
      provisions of Section 7.1 and Section 7.2, the Company shall not
      be required to issue a Warrant Agreement for Warrants covering
      less than 1,000 shares of Common Stock, except in the case of a
      partial exercise by the Warrantholder of this Warrant Agreement
      that leaves Warrants exercisable to purchase less than 1,000
      shares that are to remain registered in the name of the exercising
      Warrantholder, and any subsequent partial exercise, transfer, or
      exchange of such Warrant Agreement.

      Section 8.  Lockup Agreement.  The Warrantholder, if requested by the
Company and an underwriter of the Company's securities, shall agree not to
sell or otherwise transfer or dispose of any Warrant Shares for a specified
period of time (not to exceed 90 days) following the effective date of a
registration statement pursuant to which the Company proposes to sell its
securities to the public generally; provided, however, that all executive
officers and directors of the Company enter into similar agreements.

      Section 9.  Notices.  All notices and other communications given
pursuant to this Warrant Agreement shall be in writing.  Notices to the
Company shall be deemed to have been given when received by the Company. 
Notices to the Warrantholder shall be deemed to have been given when
personally delivered or, if mailed, upon deposit in the United States mails,
postage prepaid, addressed at the address provided to the Company and set
forth in the Company's registry books.  Notices mailed to the Warrantholder
shall be sent via airmail if the Warrantholder's address is outside the United
States.  Notices to the Company should be addressed as follows:

                  Epitope, Inc.
                  8505 S.W. Creekside Place
                  Beaverton, Oregon  97008
                  Attention:  Adolph J. Ferro, Ph.D., President and
                                   Chief Executive Officer

            With a copy (which shall not constitute notice) to:

                  Miller, Nash, Wiener, Hager & Carlsen
                  3500 U. S. Bancorp Tower
                  111 S.W. Fifth Avenue
                  Portland, Oregon  97204
                  Attention:  Erich W. Merrill, Jr.

Such addresses for notices may be changed by any party by notice to the other
party pursuant to this Section 9.

      Section 10.  Amendment.  This Warrant Agreement may be amended only by
an instrument in writing signed by the Company and the Warrantholder.

      Section 11.  Law Governing.  This Warrant Agreement shall be construed
and enforced in accordance with and governed by the laws of the state of 
<PAGE>
Oregon, United States of America, applicable to contracts to be performed in
such state between residents thereof, without regard to the conflicts of law
provisions of such state. 

      Dated as of [date]

                                    EPITOPE, INC.


                                    By_____________________
                                      Adolph J. Ferro, Ph.D.
                                      President

Attest:


By____________________
  Andrew S. Goldstein
  Secretary

<PAGE>
                         ELECTION TO EXERCISE WARRANT

      [NOTE: Unless the Warrant Shares have been registered under the
      1933 Act or are exempt from registration thereunder, this Election
      to Exercise Warrant must be executed, and the Warrant Shares must
      be delivered, outside of the United States of America, its
      territories and possessions.]

To:   Epitope, Inc.
      8505 Creekside Place
      Beaverton, Oregon  97008
      United States of America

            The undersigned hereby exercises the within Warrant Agreement for
________ shares of the Common Stock of Epitope, Inc., and tenders payment
herewith in the amount of U.S. $_________ in accordance with the terms
thereof.

            The undersigned hereby certifies that (mark one of the two
responses below):

            ___   (i) It is the sole beneficial owner of the Warrants being
                  exercised, (ii) it is not a U.S. person, within the meaning
                  of Regulation S promulgated by the United States Securities
                  and Exchange Commission pursuant to the Securities Act of
                  1933 ("1933 Act"), and (iii) it is not exercising Warrants
                  for the benefit of any U.S. person.

                                    --OR--

            ___   The securities to be delivered upon exercise of the Warrant
                  ("Warrant Shares") have been registered under the 1933 Act
                  or are exempt from registration thereunder and Epitope,
                  Inc., has been provided with a written opinion of counsel to
                  that effect.  [A legal opinion regarding the registration of
                  the Warrant Shares will be obtained at the expense of
                  Epitope, Inc., by its designated legal counsel upon notice
                  of exercise of the Warrant Agreement by the Warrantholder at
                  any time after the effective date of a registration
                  statement covering the Warrant Shares; any other legal
                  opinion shall be the responsibility of the Warrantholder.]

      Please deliver the certificate and a new Warrant Agreement for the
unexercised Warrants, if any, to:
                        ____________________________________
                        ____________________________________
                        ____________________________________

                                          
_______________________________________
Name and Title:

Dated:  ____________, 199_

Warrantholder:    _____________________________________
Address:          _____________________________________
                  _____________________________________
                  _____________________________________
<PAGE>
                              FORM OF ASSIGNMENT

      [NOTE: Unless the Warrants have been registered under the 1933 Act
      or are exempt from registration thereunder, this Assignment must
      be executed, and the re-issued Warrants must be delivered, outside
      of the United States of America, its territories and possessions.]



      FOR VALUE RECEIVED, the undersigned registered owner of this Warrant
Agreement hereby sells, assigns, and transfers unto the Assignee(s) named
below all of the rights of the undersigned under the Warrant Agreement, with
respect to Warrants for the number of shares of Common Stock set forth below:


Name of Assignee        Address                No. of Shares*
- ----------------        -------                -------------







      *Please note that the minimum denomination in which Warrant Agreements
may be issued is 1,000 shares of Common Stock.



      Dated: ____________, 19___.

                                    Warrantholder:__________________________



                                    By___________________________________
                                         Title:

                                    [Name of warrantholder must be identical
                                    to name shown in the registry books of the
                                    Company; signature must be guaranteed by a
                                    bank or brokerage firm doing business in
                                    the United States.]


<PAGE>
                                                                   Exhibit 4.2
                       [Form of Notice -- 1992 Warrants]
                           NOTICE TO WARRANTHOLDERS
                                   REGARDING
             EXTENSION OF EXPIRATION DATE ("Notice and Agreement")

THE WARRANTS REFERRED TO BELOW AND THE SHARES OF COMMON STOCK UNDERLYING THE
WARRANTS HAVE NOT BEEN REGISTERED FOR ISSUANCE TO THE WARRANTHOLDERS UNDER THE
UNITED STATES SECURITIES ACT OF 1933, AS AMENDED ("1933 ACT"), AND MAY NOT BE
OFFERED, SOLD, TRANSFERRED, PLEDGED, OR OTHERWISE DISPOSED OF, IN WHOLE OR IN
PART, DIRECTLY OR INDIRECTLY, IN THE UNITED STATES OR TO A U. S. PERSON (AS
SUCH TERMS ARE DEFINED IN REGULATION S UNDER THE 1933 ACT), NOR MAY THE
WARRANTS BE EXERCISED IN THE UNITED STATES OR BY OR ON BEHALF OF A U. S.
PERSON, UNLESS (i) THE TRANSACTION IS REGISTERED UNDER THE 1933 ACT AND ANY
APPLICABLE SECURITIES LAWS OF ANY STATE, TERRITORY OR POSSESSION OF THE UNITED
STATES OR THE DISTRICT OF COLUMBIA ("STATE ACT"), OR (ii) AN EXEMPTION FROM
REGISTRATION UNDER THE 1933 ACT OR ANY APPLICABLE STATE ACT IS AVAILABLE AND
THE ISSUER HAS RECEIVED AN OPINION OF COUNSEL TO SUCH EFFECT REASONABLY
SATISFACTORY TO IT.

[Name and Address of Warrantholder]

          Reference is made to the warrants ("Warrants") to purchase common
stock, no par value ("Common Stock"), of Epitope, Inc. (the "Company")
originally issued by the Company on December 23, 1992, and the related Warrant
Agreements ("Warrant Agreements") dated as of the same date containing the
terms of the Warrants.  Capitalized terms used and not otherwise defined
herein have the same meanings as in the Warrant Agreements.

          The Expiration Date for the Warrants, as previously extended, is
September 30, 1996.  The Company hereby further extends the Expiration Date
until September 30, 1997, and will permit all Warrantholders to exercise
Warrants through that date.  Exercise of the Warrants remains subject to the
following conditions:

          (a)   The Exercise Price is $18.50; and

          (b)   Common Stock purchased by Warrantholders pursuant to the
                exercise of Warrants may not be sold or otherwise transferred
                or disposed of for a period ending 60 days after the date of
                purchase of such Common Stock.

          Please attach a copy of this notice to your Warrant Agreement.

Dated:  September ___, 1996.

                                    EPITOPE, INC.
                                    By
                                         -----------------------------
                                         President
<PAGE>
THESE WARRANTS AND THE SHARES OF COMMON STOCK UNDERLYING THESE WARRANTS HAVE
NOT BEEN REGISTERED UNDER THE UNITED STATES SECURITIES ACT OF 1933, AS AMENDED
("1933 ACT"), AND MAY NOT BE OFFERED, SOLD, TRANSFERRED, PLEDGED, OR OTHERWISE
DISPOSED OF, IN WHOLE OR IN PART, DIRECTLY OR INDIRECTLY, IN THE UNITED STATES
OR TO A U.S. PERSON (AS SUCH TERMS ARE DEFINED IN REGULATION S UNDER THE 1933
ACT), NOR MAY THESE WARRANTS BE EXERCISED IN THE UNITED STATES OR BY OR ON
BEHALF OF A U.S. PERSON, UNLESS (i) THE TRANSACTION IS REGISTERED UNDER THE
1933 ACT AND ANY APPLICABLE SECURITIES LAWS OF ANY STATE, TERRITORY OR
POSSESSION OF THE UNITED STATES OR THE DISTRICT OF COLUMBIA ("STATE ACT"), OR
(ii) AN EXEMPTION FROM REGISTRATION UNDER THE 1933 ACT OR ANY APPLICABLE STATE
ACT IS AVAILABLE AND THE ISSUER HAS RECEIVED AN OPINION OF COUNSEL TO SUCH
EFFECT REASONABLY SATISFACTORY TO IT. 

COMMON STOCK PURCHASED PURSUANT TO THE EXERCISE OF THESE WARRANTS MAY NOT BE
SOLD OR OTHERWISE TRANSFERRED OR DISPOSED OF FOR A PERIOD OF 60 DAYS AFTER THE
DATE OF PURCHASE OF SUCH COMMON STOCK

                VOID AFTER 5 P.M., UNITED STATES PACIFIC TIME,
                             ON SEPTEMBER 30, 1997
                   OR SUCH EARLIER DATE AS SPECIFIED HEREIN

                       WARRANTS TO PURCHASE COMMON STOCK

Warrant No.              [Number of Warrants] Warrants


                                 EPITOPE, INC.

THIS CERTIFIES THAT

                            [Name of Warrantholder]

or registered assigns, is the registered holder of the number of Warrants
(each, a "Warrant," and collectively, "Warrants") set forth above.  Each
Warrant represented by this certificate for Warrants ("Warrant Agreement")
entitles the registered holder thereof (the "Warrantholder") to purchase from
Epitope, Inc., a corporation incorporated under the laws of the state of
Oregon ("Company"), United States of America ("U.S."), one fully paid and
nonassessable share of common stock, no par value, of the Company ("Common
Stock") upon presentation and surrender of this Warrant Agreement with the
accompanying Election to Exercise Warrants duly completed, at any time prior
to 5 P.M., U.S. Pacific time, on the Expiration Date (as defined in
Section 2), at the corporate offices of the Company at 8505 S.W. Creekside
Place, Beaverton, Oregon 97008, or at such other address as may be specified
by the Company pursuant to Section 9, accompanied by payment of the Exercise
Price (as defined herein) and any applicable taxes, either in cash in U.S.
funds or by certified or official bank check in U.S. funds payable to the
order of the Company.  These Warrants are issued pursuant to a Warrant
Purchase Agreement ("Purchase Agreement") among the Company and the Investors
described therein dated as of November 25, 1992.

      Section 1.  Exercise Price.  Each Warrant entitles the Warrantholder to
purchase one share of Common Stock for U.S. $18.50 (the "Exercise Price"),
subject to adjustment as provided herein.

      Section 2.  Expiration.  All Warrants not theretofore exercised shall
expire at 5 p.m., U.S. Pacific time, on the earlier of the following dates
(the "Expiration Date"):  (a) September 30, 1997 and (b) the expiration of 120
days after the first period of 20 consecutive trading days during which period
the average of the high and low sales prices of the Common Stock on the
American Stock Exchange, or any other exchange or national market system on
which the Common Stock is then traded, is at least $30.00.  

      Section 3.  Adjustments of Number and Kind of Shares Purchasable and
Exercise Price.  The number and kind of securities or other property
purchasable upon exercise of a Warrant shall be subject to adjustment from
time to time upon the occurrence, after the date hereof, of the following
events:

            3.1  If the outstanding shares of the Company's Common Stock
      are divided into a greater number of shares or a dividend in
      Common Stock is paid on the Common Stock, the number of shares of
      Common Stock issuable on exercise of the Warrants shall be
      proportionately increased and the Exercise Price in effect
      immediately prior to such subdivision or at the record date of
      such dividend shall, simultaneously with the effectiveness of such
      subdivision or immediately after the record date of such dividend,
      be proportionately reduced; and, conversely, if the outstanding
      shares of Common Stock are combined into a smaller number of
      shares of Common Stock, the number of shares of Common Stock
      issuable upon exercise of the Warrants shall be proportionately
      reduced and the Exercise Price in effect immediately prior to such
      combination shall, simultaneously with the effectiveness of such
      combination, be proportionately increased.  The increases and
      reductions provided for in this subsection 3.1 shall be made with
      the intent and, as nearly as practicable, the effect that neither
      the percentage of the total equity of the Company issuable on
      exercise of the Warrants nor the price payable for such percentage
      upon such exercise shall be affected by any event described in
      this subsection 3.1.

            3.2  No adjustment of the Exercise Price will be made if the
      amount of the adjustment is less than U.S. $.01 per share, but in
      that case any adjustment that would otherwise be required to be
      made will be carried forward and will be made at the time of and
      together with the next adjustment of the Exercise Price which,
      together with any adjustment carried forward, amounts to U.S. $.01
      per share or more.

            3.3  In case of any change in the Common Stock of the
      Company through merger, consolidation, reclassification,
      reorganization, partial or complete liquidation, or other change
      in the capital structure of the Company (not including a
      combination of shares or the issuance of additional shares of
      Common Stock by the Company by stock split or stock dividend),
      then, as a condition of the change in the capital structure of the
      Company, provision shall be made so that the holder of this
      Warrant Agreement will have the right thereafter to receive upon
      the exercise of the Warrants the kind and amount of shares of
      stock or other securities or property to which such holder would
      have been entitled if, immediately prior to such merger,
      consolidation, reclassification, reorganization, recapitalization,
      or other change in the capital structure, such holder had held the
      number of shares of Common Stock issuable upon the exercise of the
      Warrants.  In any such case, appropriate adjustment shall be made
      in the application of the provisions set forth herein with respect
      to the rights and interest thereafter of the Warrantholder, to the
      end that the provisions set forth herein shall thereafter be
      applicable, as nearly as reasonably may be, in relation to any
      shares of stock or other property thereafter deliverable upon the
      exercise of the Warrants.  The Company will not permit any change
      in its capital structure to occur unless the issuer of the shares
      of stock or other securities to be received by the holder of this
      Warrant Agreement, if not the Company, agrees to be bound by and
      comply with the provisions of this Warrant Agreement.

            3.4  When any adjustment is required to be made in the
      number of shares of Common Stock, other securities, or property
      purchasable upon exercise of the Warrants, the Company shall
      promptly determine the new number of shares or other securities or
      property purchasable upon exercise of the Warrants and (a) prepare
      and retain on file a statement describing in reasonable detail the
      method used in arriving at the new number of shares or other
      securities or property purchasable upon exercise of the Warrants
      and (b) cause a copy of such statement to be mailed to the
      Warrantholder within thirty (30) days after the date when the
      event giving rise to the adjustment occurred.

            3.5  No fractional shares of Common Stock or other
      securities shall be issued in connection with the exercise of any
      Warrants, but the Company shall pay, in lieu of fractional shares,
      a cash payment therefor on the basis of the closing price on a
      national securities exchange on the day immediately prior to
      exercise or, if the Common Stock or other securities are not
      traded on a national securities exchange on such day, on the basis
      of the fair market value thereof as determined by the board of
      directors of the Company, which determination shall be conclusive.

            3.6  Notwithstanding anything herein to the contrary, there
      shall be no adjustment made hereunder on account of the sale and
      issuance of the shares of Common Stock or other securities
      purchasable upon exercise of the Warrants.

      Section 4.  Rights of Warrantholder as Shareholder.  No holder of this
Warrant Agreement shall, as such, be entitled to vote, receive dividends, or
be deemed the holder of Common Stock or any other securities of the Company
that may at any time be issuable on the exercise hereof for any purpose
whatever, nor shall anything contained herein be construed to confer upon the
holder of this Warrant Agreement, as such, any of the rights of a shareholder
of the Company or any right to vote for the election of directors or upon any
matter submitted to shareholders at any meeting thereof or give or withhold
consent to any corporate action (whether upon any matter submitted to
shareholders at any meeting thereof or otherwise) including, without
limitation, giving or withholding consent to any merger, recapitalization,
issuance of stock, reclassification of stock, exchange of stock, change of
stock to par value, consolidation or conveyance, or to receive notice of
meetings or other actions affecting shareholders or to receive dividends or
subscription rights or other distributions.

      Section 5.  Payment of Certain Taxes and Charges.  The Company shall not
be required to issue or deliver any certificate for shares of Common Stock or
other securities upon the exercise of Warrants evidenced by this Warrant
Agreement or to register the transfer of the Warrants evidenced hereby until
any applicable transfer tax and any other taxes or governmental charges that
the Company may be required by law to collect in respect of such exercise or
transfer shall have been paid, such tax being payable by the holder of this
Warrant Agreement at the time of surrender for exercise or transfer.

      Section 6.  Registration.  The Company has prepared a registration
statement on Form S-3 (the "Registration Statement") under the 1933 Act with
respect to transfer by the Warrantholder of the Warrants covered by this
Warrant Agreement and the re-sale by the Warrantholder of the shares of Common
Stock issued or issuable upon exercise of this Warrant Agreement (the "Warrant
Shares").  As soon as practicable after the original issue date of this
Warrant Agreement (the "Original Issue Date"), the Company shall file the
Registration Statement with the U.S. Securities and Exchange Commission and
shall use its best efforts to cause the Registration Statement to become
effective under the 1933 Act as promptly as practicable after the Original
Issue Date as provided for in, and in accordance with, the terms and
conditions of the Purchase Agreement.  

      Section 7.  Transfer and Exchange.

            7.1   Transfer.  This Warrant Agreement is transferable on
      the registry books of the Company subject to the restrictions on
      the first page hereof and in Section 7.4.  The Company may deem
      and treat the person or entity in whose name this Warrant
      Agreement is registered as the absolute owner hereof
      (notwithstanding any notation of ownership or other writing
      thereon made by anyone other than the Company) for all purposes
      whatever, and the Company shall not be affected by any notice to
      the contrary.

            7.2   Exchange.  Subject to the provisions of Section 7.4
      and the restrictions on the first page hereof, this Warrant
      Agreement is exchangeable at the principal office of the Company
      for Warrant Agreements to purchase the same aggregate number of
      shares of Common Stock as are purchasable hereunder, each new
      Warrant Agreement to represent the right to purchase such number
      of shares as the Warrantholder shall designate at the time of such
      exchange.

            7.3   Securities Act of 1933.  The Warrantholder, by
      acceptance hereof, agrees that this Warrant Agreement and the
      shares of Common Stock issued or issuable upon exercise of this
      Warrant Agreement may not be offered or sold except in compliance
      with the 1933 Act.  The Warrantholder consents to the Company's
      making a notation on its records and on the certificates for any
      shares of Common Stock issued upon exercise hereof in order to
      implement such restriction on transferability.

            7.4   Minimum Warrant Agreement Amount.  Notwithstanding the
      provisions of Section 7.1 and Section 7.2, the Company shall not
      be required to issue a Warrant Agreement for Warrants covering
      less than 1,000 shares of Common Stock, except in the case of a
      partial exercise by the Warrantholder of this Warrant Agreement
      that leaves Warrants exercisable to purchase less than 1,000
      shares that are to remain registered in the name of the exercising
      Warrantholder, and any subsequent partial exercise, transfer, or
      exchange of such Warrant Agreement.

            7.5   No Transfer of Common Stock for 60 Days.  Common Stock
      purchased pursuant to the exercise of these Warrants may not be
      sold or otherwise transferred or disposed of for a period of 60
      days after the date of purchase of such Common Stock.

      Section 8.  Holdback Agreement.  The Warrantholder, if requested by the
Company and an underwriter of the Company's securities, shall agree not to
sell or otherwise transfer or dispose of any Warrants or Warrant Shares for a
specified period of time (not to exceed 90 days) following the effective date
of a registration statement pursuant to which the Company proposes to sell its
securities to the public generally; provided, however, that all executive
officers and directors of the Company enter into similar agreements.

      Section 9.  Notices.  Any notice, request, or other communication
required or permitted hereunder shall be in writing and shall be deemed to
have been duly given if delivered personally, by international courier
service, or by registered mail, airmail postage prepaid, return receipt
requested, to:  (a) the Company at 8505 S.W. Creekside Place, Beaverton,
Oregon 97008, U.S.A., Attn:  Secretary, with a copy to Miller, Nash, Wiener,
Hager & Carlsen, 3500 U. S. Bancorp Tower, 111 S.W. Fifth Avenue, Portland,
Oregon 97204, U.S.A., Attn:  Erich W. Merrill, Jr., or at such other addresses
as may be specified by the Company by notice given to the Warrantholders in
accordance with this Section 9, and (b) to the Warrantholders at the addresses
set forth in the registry books of the Company referred to in Section 7.1,
with copies to Michel de Beaumont, American Equities Overseas (U.K.) Ltd., 16
Old Bond Street, London W1X 3DB, United Kingdom, and Jack H. Halperin, Esq.,
361 Silver Court, Woodmere, New York 11598, U.S.A.  Any notice, request or
other communication (other than an Election to Exercise Warrants) given by
registered airmail shall be deemed given 10 days after the mailing date;
notices, requests, or other communications given in any other manner and any
Election to Exercise Warrants shall be deemed given when received.

      Section 10.  Amendment.  This Warrant Agreement may be amended or its
provisions waived only by an instrument in writing signed by the Company and
the Warrantholder as provided in the Purchase Agreement.

      Section 11.  Certain Definitions.  Rules 9.02(o) and 9.02(p) of
Regulation S promulgated under the 1933 Act defining "U.S. person" and "United
States," respectively, are set forth in Appendix 1.

      Section 12.  Law Governing.  This Warrant Agreement shall be governed by
and construed in accordance with the laws of the state of Oregon, without
giving effect to choice of laws principles thereof. 

      Dated as of [Date]

                                    EPITOPE, INC.


                                    By
                                      -----------------------------------
                                      


<PAGE>
                                  APPENDIX 1

                                      to

                               Warrant Agreement



            Set forth below is the text of Rule 902(o) promulgated under the
1933 Act which defines "U.S. person" as follows:

            (o)  U.S. Person.

            (1)  "U.S. person" means:

            (i)  Any natural person resident in the United States;

            (ii)  Any partnership or corporation organized or
      incorporated under the laws of the United States;

            (iii)  Any estate of which any executor or administrator is
      a U.S. person;

            (iv)  Any trust of which any trustee is a U.S. person;

            (v)  Any agency or branch of a foreign entity located in the
      United States;

            (vi)  Any nondiscretionary account or similar account (other
      than an estate or trust) held by a dealer or other fiduciary for
      the benefit or account of a U.S. person;

            (vii)  Any discretionary account or similar account (other
      than an estate or trust) held by a dealer or other fiduciary
      organized, incorporated, or (if an individual) resident in the
      United States; and

            (viii)  Any partnership or corporation if:  (A) organized or
      incorporated under the laws of any foreign jurisdiction; and
      (B) formed by a U.S. person principally for the purpose of
      investing in securities not registered under the 1933 Act, unless
      it is organized or incorporated, and owned, by accredited
      investors (as defined in Rule 501(a)) who are not natural persons,
      estates or trusts.

            (2)  Notwithstanding paragraph (o)(1) of this rule, any
discretionary account or similar account (other than an estate or trust) held
for the benefit or account of a non-U.S. person by a dealer or other
professional fiduciary organized, incorporated, or (if an individual) resident
in the United States shall not be deemed a "U.S. person."

            (3)  Notwithstanding paragraph (o)(1), any estate of which any
professional fiduciary acting as executor or administrator is a U.S. person
shall not be deemed a U.S. person if:

            (i)  An executor or administrator of the estate who is not a
      U.S. person has sole or shared investment discretion with respect
      to the assets of the estate; and

            (ii)  The estate is governed by foreign law.

            (4)  Notwithstanding paragraph (o)(1), any trust of which any
professional fiduciary acting as trustee is a U.S. person shall not be deemed
a U.S. person if a trustee who is not a U.S. person has sole or shared
investment discretion with respect to the trust assets, and no beneficiary of
the trust (and no settlor if the trust is revocable) is a U.S. person.

            (5)  Notwithstanding paragraph (o)(1), an employee benefit plan
established and administered in accordance with the law of a country other
than the United States and customary practices and documentation of such
country shall not be deemed a U.S. person.

            (6)  Notwithstanding paragraph (o)(1), any agency or branch of a
U.S. person located outside the United States shall not be deemed a
"U.S. person" if:

            (i)  The agency or branch operates for valid business
      reasons; and

            (ii)  The agency or branch is engaged in the business of
      insurance or banking and is subject to substantive insurance or
      banking regulation, respectively, in the jurisdiction where
      located.

            (7)  The International Monetary Fund, the International Bank for
Reconstruction and Development, the Inter-American Development Bank, the Asian
Development Bank, the African Development Bank, the United Nations, and their
agencies, affiliates and pension plans, and any other similar international
organizations, their agencies, affiliates and pension plans shall not be
deemed "U.S. persons."

            Set forth below is the text of Rule 9.02(p) promulgated under the
1933 Act which defines "United States" as follows:

            (p)  "United States" means the United States of America, its
territories and possessions, any State of the United States, and the District
of Columbia.
<PAGE>
                         ELECTION TO EXERCISE WARRANTS

      [NOTE: Unless the transaction has been registered under the 1933
      Act or is exempt from registration thereunder, this Election to
      Exercise Warrants must be executed, and the Warrant Shares must be
      delivered, outside of the U.S., its territories and possessions.]

To:   Epitope, Inc.
      8505 S.W. Creekside Place
      Beaverton, Oregon  97008
      U.S.A.

            The undersigned hereby exercises Warrants represented by the
within Warrant Agreement for ________ shares of the Common Stock of Epitope,
Inc. ("Warrant Shares"), and tenders payment herewith in the amount of
U.S. $_________ in accordance with the terms thereof.

            The undersigned hereby certifies that (mark one of the two
responses below):

            ___   (i) It is the sole beneficial owner of the Warrants being
                  exercised, (ii) it is not a U.S. person, as defined in
                  Appendix 1 to the within Warrant Agreement and within the
                  meaning of Regulation S promulgated by the U.S. Securities
                  and Exchange Commission pursuant to the Securities Act of
                  1933 ("1933 Act"), and (iii) it is not exercising Warrants
                  for the benefit of any U.S. person.

                                    --OR--

            ___   The transaction in which the Warrant Shares will be
                  delivered upon exercise of the Warrant has been registered
                  under the 1933 Act or is exempt from registration thereunder
                  and Epitope, Inc., has been provided with a written opinion
                  of counsel to that effect or has waived the requirement for
                  an opinion.  A legal opinion regarding the registration of
                  the transaction will be obtained at the expense of Epitope,
                  Inc., by its designated legal counsel upon notice of
                  exercise of the Warrant Agreement by the Warrantholder at
                  any time after the effective date of a registration
                  statement covering the transaction; any other legal opinion
                  shall be the responsibility of the Warrantholder.

            THE UNDERSIGNED HEREBY AGREES NOT TO SELL OR OTHERWISE TRANSFER OR
DISPOSE OF THE WARRANT SHARES FOR A PERIOD ENDING 60 DAYS AFTER THE DATE OF
PURCHASE OF THE WARRANT SHARES.

      Please deliver the certificate and a new Warrant Agreement for the
unexercised Warrants, if any, to:

                        ____________________________________
                        ____________________________________
                        ____________________________________

                                    Warrantholder:__________________________

                                    By___________________________________
                                      Title:

                                    [Name of Warrantholder must be identical
                                    to name shown in the registry books of the
                                    Company; signature must be guaranteed by a
                                    bank or brokerage firm doing business in
                                    the U.S.]
Dated:  ____________, 199_

Warrantholder:    _____________________________________
Address:    _____________________________________
            _____________________________________
            _____________________________________
<PAGE>
                              FORM OF ASSIGNMENT

      [NOTE: Unless the transaction has been registered under the 1933
      Act or is exempt from registration thereunder, this Assignment
      must be executed, and the re-issued Warrants must be delivered,
      outside of the U.S., its territories and possessions.]



      FOR VALUE RECEIVED, the undersigned registered owner of this Warrant
Agreement hereby sells, assigns, and transfers to the Assignee(s) named below
all of the rights of the undersigned under the Warrant Agreement, with respect
to Warrants for the number of shares of Common Stock set forth below:


Name of Assignee       Address                   No. of Shares*
- ----------------       -------                   -------------







      *Please note that the minimum denomination in which Warrant Agreements
may be issued is 1,000 shares of Common Stock.



      Dated: ____________, 19___.

                                    Warrantholder:__________________________



                                         By___________________________________
                                                  Title:

                                    [Name of Warrantholder must be identical
                                    to name shown in the registry books of the
                                    Company; signature must be guaranteed by a
                                    bank or brokerage firm doing business in
                                    the U.S.]


<PAGE>
                                                                   Exhibit 4.3

                       [Form of Notice -- 1993 Warrants]


                           NOTICE TO WARRANTHOLDERS
                                   REGARDING
                         EXTENSION OF EXPIRATION DATE

THE WARRANTS REFERRED TO BELOW AND THE SHARES OF COMMON STOCK UNDERLYING THE
WARRANTS HAVE NOT BEEN REGISTERED FOR ISSUANCE TO THE WARRANTHOLDERS UNDER THE
UNITED STATES SECURITIES ACT OF 1933, AS AMENDED ("1933 ACT"), AND MAY NOT BE
OFFERED, SOLD, TRANSFERRED, PLEDGED, OR OTHERWISE DISPOSED OF, IN WHOLE OR IN
PART, DIRECTLY OR INDIRECTLY, IN THE UNITED STATES OR TO A U. S. PERSON (AS
SUCH TERMS ARE DEFINED IN REGULATION S UNDER THE 1933 ACT), NOR MAY THE
WARRANTS BE EXERCISED IN THE UNITED STATES OR BY OR ON BEHALF OF A U. S.
PERSON, UNLESS (i) THE TRANSACTION IS REGISTERED UNDER THE 1933 ACT AND ANY
APPLICABLE SECURITIES LAWS OF ANY STATE, TERRITORY OR POSSESSION OF THE UNITED
STATES OR THE DISTRICT OF COLUMBIA ("STATE ACT"), OR (ii) AN EXEMPTION FROM
REGISTRATION UNDER THE 1933 ACT OR ANY APPLICABLE STATE ACT IS AVAILABLE AND
THE ISSUER HAS RECEIVED AN OPINION OF COUNSEL TO SUCH EFFECT REASONABLY
SATISFACTORY TO IT.

[Name and Address of Warrantholder]


          Reference is made to the warrants ("Warrants") to purchase common
stock, no par value ("Common Stock"), of Epitope, Inc. (the "Company")
originally issued by the Company on July 23, 1993, and the related Warrant
Agreements ("Warrant Agreements") dated as of the same date containing the
terms of the Warrants.  Capitalized terms used and not otherwise defined
herein have the same meanings as in the Warrant Agreements.

          The Expiration Date for the Warrants, as previously extended, is
March 31, 1997.  The Company hereby further extends the Expiration Date until
September 30, 1997, and will permit all Warrantholders to exercise Warrants
through that date.  Exercise of the Warrants remains subject to the condition
that Common Stock purchased by Warrantholders pursuant to the exercise of
Warrants may not be sold or otherwise transferred or disposed of for a period
ending 60 days after the date of purchase of such Common Stock.

          Please attach a copy of this notice to your Warrant Agreement.

Dated:  September ___, 1996.

                                    EPITOPE, INC.

                                    By 
                                       --------------------------------
                                       President
<PAGE>
THESE WARRANTS AND THE SHARES OF COMMON STOCK UNDERLYING THESE WARRANTS HAVE
NOT BEEN REGISTERED UNDER THE UNITED STATES SECURITIES ACT OF 1933, AS AMENDED
("1933 ACT"), AND MAY NOT BE OFFERED, SOLD, TRANSFERRED, PLEDGED, OR OTHERWISE
DISPOSED OF, IN WHOLE OR IN PART, DIRECTLY OR INDIRECTLY, IN THE UNITED STATES
OR TO A U.S. PERSON (AS SUCH TERMS ARE DEFINED IN REGULATION S UNDER THE 1933
ACT), NOR MAY THESE WARRANTS BE EXERCISED IN THE UNITED STATES OR BY OR ON
BEHALF OF A U.S. PERSON, UNLESS (i) THE TRANSACTION IS REGISTERED UNDER THE
1933 ACT AND ANY APPLICABLE SECURITIES LAWS OF ANY STATE, TERRITORY OR
POSSESSION OF THE UNITED STATES OR THE DISTRICT OF COLUMBIA ("STATE ACT"), OR
(ii) AN EXEMPTION FROM REGISTRATION UNDER THE 1933 ACT OR ANY APPLICABLE STATE
ACT IS AVAILABLE AND THE ISSUER HAS RECEIVED AN OPINION OF COUNSEL TO SUCH
EFFECT REASONABLY SATISFACTORY TO IT. 

COMMON STOCK PURCHASED PURSUANT TO THE EXERCISE OF THESE WARRANTS MAY NOT BE
SOLD OR OTHERWISE TRANSFERRED OR DISPOSED OF FOR A PERIOD OF 60 DAYS AFTER THE
DATE OF PURCHASE OF SUCH COMMON STOCK.


                VOID AFTER 5 P.M., UNITED STATES PACIFIC TIME,
                             ON SEPTEMBER 30, 1997
                   OR SUCH EARLIER DATE AS SPECIFIED HEREIN

                       WARRANTS TO PURCHASE COMMON STOCK

Warrant No. 93I-         [Number of Warrants] Warrants


                                 EPITOPE, INC.

THIS CERTIFIES THAT

                            [Name of Warrantholder]

or registered assigns, is the registered holder of the number of Warrants
(each, a "Warrant," and collectively, "Warrants") set forth above.  Each
Warrant represented by this certificate for Warrants ("Warrant Agreement")
entitles the registered holder thereof (the "Warrantholder") to purchase from
Epitope, Inc., a corporation incorporated under the laws of the state of
Oregon ("Company"), United States of America ("U.S."), one fully paid and
nonassessable share of common stock, no par value, of the Company ("Common
Stock") upon presentation and surrender of this Warrant Agreement with the
accompanying Election to Exercise Warrants duly completed, at any time after
the Common Stock issuable upon exercise of this Warrant has been approved for
listing on the American Stock Exchange upon official notice of issuance, and
prior to 5 P.M., U.S. Pacific time, on the Expiration Date (as defined in
Section 2), at the corporate offices of the Company at 8505 S.W. Creekside
Place, Beaverton, Oregon 97008, or at such other address as may be specified
by the Company pursuant to Section 9, accompanied by payment of the Exercise
Price (as defined herein) and any applicable taxes, either in cash in U.S.
funds or by certified or official bank check in U.S. funds payable to the
order of the Company.  These Warrants are issued pursuant to a 1993 Warrant
Purchase Agreement ("Purchase Agreement") among the Company and the Investors
described therein dated as of July 6, 1993.

      Section 1.  Exercise Price.  Each Warrant entitles the Warrantholder to
purchase one share of Common Stock for U.S. $20.00 (the "Exercise Price"),
subject to adjustment as provided herein.

      Section 2.  Expiration.  All Warrants not theretofore exercised shall
expire at 5 p.m., U.S. Pacific time, on the earlier of the following dates
(the "Expiration Date"):  (a) September 30, 1997, and (b) the expiration of
120 days after the first period of 20 consecutive trading days during which
period the average of the high and low sales prices of the Common Stock on the
American Stock Exchange, or any other exchange or national market system on
which the Common Stock is then traded, is at least $30.00.  

      Section 3.  Adjustments of Number and Kind of Shares Purchasable and
Exercise Price.  The number and kind of securities or other property
purchasable upon exercise of a Warrant shall be subject to adjustment from
time to time upon the occurrence, after the date hereof, of the following
events:

            3.1  If the outstanding shares of the Company's Common Stock
      are divided into a greater number of shares or a dividend in
      Common Stock is paid on the Common Stock, the number of shares of
      Common Stock issuable on exercise of the Warrants shall be
      proportionately increased and the Exercise Price in effect
      immediately prior to such subdivision or at the record date of
      such dividend shall, simultaneously with the effectiveness of such
      subdivision or immediately after the record date of such dividend,
      be proportionately reduced; and, conversely, if the outstanding
      shares of Common Stock are combined into a smaller number of
      shares of Common Stock, the number of shares of Common Stock
      issuable upon exercise of the Warrants shall be proportionately
      reduced and the Exercise Price in effect immediately prior to such
      combination shall, simultaneously with the effectiveness of such
      combination, be proportionately increased.  The increases and
      reductions provided for in this subsection 3.1 shall be made with
      the intent and, as nearly as practicable, the effect that neither
      the percentage of the total equity of the Company issuable on
      exercise of the Warrants nor the price payable for such percentage
      upon such exercise shall be affected by any event described in
      this subsection 3.1.

            3.2  No adjustment of the Exercise Price will be made if the
      amount of the adjustment is less than U.S. $.01 per share, but in
      that case any adjustment that would otherwise be required to be
      made will be carried forward and will be made at the time of and
      together with the next adjustment of the Exercise Price which,
      together with any adjustment carried forward, amounts to U.S. $.01
      per share or more.

            3.3  In case of any change in the Common Stock of the
      Company through merger, consolidation, reclassification,
      reorganization, partial or complete liquidation, or other change
      in the capital structure of the Company (not including a
      combination of shares or the issuance of additional shares of
      Common Stock by the Company by stock split or stock dividend),
      then, as a condition of the change in the capital structure of the
      Company, provision shall be made so that the holder of this
      Warrant Agreement will have the right thereafter to receive upon
      the exercise of the Warrants the kind and amount of shares of
      stock or other securities or property to which such holder would
      have been entitled if, immediately prior to such merger,
      consolidation, reclassification, reorganization, recapitalization,
      or other change in the capital structure, such holder had held the
      number of shares of Common Stock issuable upon the exercise of the
      Warrants.  In any such case, appropriate adjustment shall be made
      in the application of the provisions set forth herein with respect
      to the rights and interest thereafter of the Warrantholder, to the
      end that the provisions set forth herein shall thereafter be
      applicable, as nearly as reasonably may be, in relation to any
      shares of stock or other property thereafter deliverable upon the
      exercise of the Warrants.  The Company will not permit any change
      in its capital structure to occur unless the issuer of the shares
      of stock or other securities to be received by the holder of this
      Warrant Agreement, if not the Company, agrees to be bound by and
      comply with the provisions of this Warrant Agreement.

            3.4  When any adjustment is required to be made in the
      number of shares of Common Stock, other securities, or property
      purchasable upon exercise of the Warrants, the Company shall
      promptly determine the new number of shares or other securities or
      property purchasable upon exercise of the Warrants and (a) prepare
      and retain on file a statement describing in reasonable detail the
      method used in arriving at the new number of shares or other
      securities or property purchasable upon exercise of the Warrants
      and (b) cause a copy of such statement to be mailed to the
      Warrantholder within thirty (30) days after the date when the
      event giving rise to the adjustment occurred.

            3.5  No fractional shares of Common Stock or other
      securities shall be issued in connection with the exercise of any
      Warrants, but the Company shall pay, in lieu of fractional shares,
      a cash payment therefor on the basis of the closing price on a
      national securities exchange on the day immediately prior to
      exercise or, if the Common Stock or other securities are not
      traded on a national securities exchange on such day, on the basis
      of the fair market value thereof as determined by the board of
      directors of the Company, which determination shall be conclusive.

            3.6  Notwithstanding anything herein to the contrary, there
      shall be no adjustment made hereunder on account of the sale and
      issuance of the shares of Common Stock or other securities
      purchasable upon exercise of the Warrants.

      Section 4.  Rights of Warrantholder as Shareholder.  No holder of this
Warrant Agreement shall, as such, be entitled to vote, receive dividends, or
be deemed the holder of Common Stock or any other securities of the Company
that may at any time be issuable on the exercise hereof for any purpose
whatever, nor shall anything contained herein be construed to confer upon the
holder of this Warrant Agreement, as such, any of the rights of a shareholder
of the Company or any right to vote for the election of directors or upon any
matter submitted to shareholders at any meeting thereof or give or withhold
consent to any corporate action (whether upon any matter submitted to
shareholders at any meeting thereof or otherwise) including, without
limitation, giving or withholding consent to any merger, recapitalization,
issuance of stock, reclassification of stock, exchange of stock, change of
stock to par value, consolidation or conveyance, or to receive notice of
meetings or other actions affecting shareholders or to receive dividends or
subscription rights or other distributions.

      Section 5.  Payment of Certain Taxes and Charges.  The Company shall not
be required to issue or deliver any certificate for shares of Common Stock or
other securities upon the exercise of Warrants evidenced by this Warrant
Agreement or to register the transfer of the Warrants evidenced hereby until
any applicable transfer tax and any other taxes or governmental charges that
the Company may be required by law to collect in respect of such exercise or
transfer shall have been paid, such tax being payable by the holder of this
Warrant Agreement at the time of surrender for exercise or transfer.

      Section 6.  Registration.  The Company has prepared a registration
statement on Form S-3 (the "Registration Statement") under the 1933 Act with
respect to the resale by the Warrantholder of the Warrants covered by this
Warrant Agreement and of the shares of Common Stock issued or issuable upon
exercise of this Warrant Agreement (the "Warrant Shares").  As soon as
practicable after the original issue date of this Warrant Agreement (the
"Original Issue Date"), the Company shall file the Registration Statement with
the U.S. Securities and Exchange Commission and shall use its best efforts to
cause the Registration Statement to become effective under the 1933 Act as
promptly as practicable after the Original Issue Date as provided for in, and
in accordance with, the terms and conditions of the Purchase Agreement.  

      Section 7.  Transfer and Exchange.

            7.1   Transfer.  This Warrant Agreement is transferable on
      the registry books of the Company subject to the restrictions on
      the first page hereof and in Section 7.4.  The Company may deem
      and treat the person or entity in whose name this Warrant
      Agreement is registered as the absolute owner hereof
      (notwithstanding any notation of ownership or other writing
      thereon made by anyone other than the Company) for all purposes
      whatever, and the Company shall not be affected by any notice to
      the contrary.

            7.2   Exchange.  Subject to the provisions of Section 7.4
      and the restrictions on the first page hereof, this Warrant
      Agreement is exchangeable at the principal office of the Company
      for Warrant Agreements to purchase the same aggregate number of
      shares of Common Stock as are purchasable hereunder, each new
      Warrant Agreement to represent the right to purchase such number
      of shares as the Warrantholder shall designate at the time of such
      exchange.

            7.3   Securities Act of 1933.  The Warrantholder, by
      acceptance hereof, agrees that this Warrant Agreement and the
      shares of Common Stock issued or issuable upon exercise of this
      Warrant Agreement may not be offered or sold except in compliance
      with the 1933 Act.  The Warrantholder consents to the Company's
      making a notation on its records and on the certificates for any
      shares of Common Stock issued upon exercise hereof in order to
      implement such restriction on transferability.

            7.4   Minimum Warrant Agreement Amount.  Notwithstanding the
      provisions of Section 7.1 and Section 7.2, the Company shall not
      be required to issue a Warrant Agreement for Warrants covering
      less than 1,000 shares of Common Stock, except in the case of a
      partial exercise by the Warrantholder of this Warrant Agreement
      that leaves Warrants exercisable to purchase less than 1,000
      shares that are to remain registered in the name of the exercising
      Warrantholder, and any subsequent partial exercise, transfer, or
      exchange of such Warrant Agreement.

            7.5   No Transfer of Common Stock for 60 Days.  Common Stock
      purchased pursuant to the exercise of these Warrants may not be
      sold or otherwise transferred or disposed of for a period of 60
      days after the date of purchase of such Common Stock.

      Section 8.  Holdback Agreement.  The Warrantholder, if requested by the
Company and an underwriter of the Company's securities, shall agree not to
sell or otherwise transfer or dispose of any Warrants or Warrant Shares for a
specified period of time (not to exceed 90 days) following the effective date
of a registration statement pursuant to which the Company proposes to sell its
securities to the public generally; provided, however, that all executive
officers and directors of the Company enter into similar agreements.

      Section 9.  Notices.  Any notice, request, or other communication
required or permitted hereunder shall be in writing and shall be deemed to
have been duly given if delivered personally, by international courier
service, or by registered mail, airmail postage prepaid, return receipt
requested, to:  (a) the Company at 8505 S.W. Creekside Place, Beaverton,
Oregon 97008, U.S.A., Attn:  Secretary, with a copy to Miller, Nash, Wiener,
Hager & Carlsen, 3500 U. S. Bancorp Tower, 111 S.W. Fifth Avenue, Portland,
Oregon 97204, U.S.A., Attn:  Erich W. Merrill, Jr., or at such other addresses
as may be specified by the Company by notice given to the Warrantholders in
accordance with this Section 9, and (b) to the Warrantholders at the addresses
set forth in the registry books of the Company referred to in Section 7.1,
with copies to Michel de Beaumont, American Equities Overseas (U.K.) Ltd., 16
Old Bond Street, London W1X 3DB, United Kingdom, and Jack H. Halperin, Esq.,
361 Silver Court, Woodmere, New York 11598, U.S.A.  Any notice, request or
other communication (other than an Election to Exercise Warrants) given by
registered airmail shall be deemed given ten days after the mailing date;
notices, requests, or other communications given in any other manner and any
Election to Exercise Warrants shall be deemed given when received.

      Section 10.  Amendment.  This Warrant Agreement may be amended or its
provisions waived only by an instrument in writing signed by the Company and
the Warrantholder as provided in the Purchase Agreement.

      Section 11.  Certain Definitions.  Rules 9.02(o) and 9.02(p) of
Regulation S promulgated under the 1933 Act defining "U.S. person" and "United
States," respectively, are set forth in Appendix 1.

      Section 12.  Law Governing.  This Warrant Agreement shall be governed by
and construed in accordance with the laws of the state of Oregon, without
giving effect to choice of laws principles thereof. 

      Dated as of [Date]

                                    EPITOPE, INC.


                                    By 
                                       -------------------------------------
                                    



<PAGE>
                                  APPENDIX 1

                                      to

                               Warrant Agreement



            Set forth below is the text of Rule 902(o) promulgated under the
1933 Act which defines "U.S. person" as follows:

            (o)  U.S. Person.

            (1)  "U.S. person" means:

            (i)  Any natural person resident in the United States;

            (ii)  Any partnership or corporation organized or
      incorporated under the laws of the United States;

            (iii)  Any estate of which any executor or administrator is
      a U.S. person;

            (iv)  Any trust of which any trustee is a U.S. person;

            (v)  Any agency or branch of a foreign entity located in the
      United States;

            (vi)  Any nondiscretionary account or similar account (other
      than an estate or trust) held by a dealer or other fiduciary for
      the benefit or account of a U.S. person;

            (vii)  Any discretionary account or similar account (other
      than an estate or trust) held by a dealer or other fiduciary
      organized, incorporated, or (if an individual) resident in the
      United States; and

            (viii)  Any partnership or corporation if:  (A) organized or
      incorporated under the laws of any foreign jurisdiction; and
      (B) formed by a U.S. person principally for the purpose of
      investing in securities not registered under the 1933 Act, unless
      it is organized or incorporated, and owned, by accredited
      investors (as defined in Rule 501(a)) who are not natural persons,
      estates or trusts.

            (2)  Notwithstanding paragraph (o)(1) of this rule, any
discretionary account or similar account (other than an estate or trust) held
for the benefit or account of a non-U.S. person by a dealer or other
professional fiduciary organized, incorporated, or (if an individual) resident
in the United States shall not be deemed a "U.S. person."

            (3)  Notwithstanding paragraph (o)(1), any estate of which any
professional fiduciary acting as executor or administrator is a U.S. person
shall not be deemed a U.S. person if:

            (i)  An executor or administrator of the estate who is not a
      U.S. person has sole or shared investment discretion with respect
      to the assets of the estate; and

            (ii)  The estate is governed by foreign law.

            (4)  Notwithstanding paragraph (o)(1), any trust of which any
professional fiduciary acting as trustee is a U.S. person shall not be deemed
a U.S. person if a trustee who is not a U.S. person has sole or shared
investment discretion with respect to the trust assets, and no beneficiary of
the trust (and no settlor if the trust is revocable) is a U.S. person.

            (5)  Notwithstanding paragraph (o)(1), an employee benefit plan
established and administered in accordance with the law of a country other
than the United States and customary practices and documentation of such
country shall not be deemed a U.S. person.

            (6)  Notwithstanding paragraph (o)(1), any agency or branch of a
U.S. person located outside the United States shall not be deemed a
"U.S. person" if:

            (i)  The agency or branch operates for valid business
      reasons; and

            (ii)  The agency or branch is engaged in the business of
      insurance or banking and is subject to substantive insurance or
      banking regulation, respectively, in the jurisdiction where
      located.

            (7)  The International Monetary Fund, the International Bank for
Reconstruction and Development, the Inter-American Development Bank, the Asian
Development Bank, the African Development Bank, the United Nations, and their
agencies, affiliates and pension plans, and any other similar international
organizations, their agencies, affiliates and pension plans shall not be
deemed "U.S. persons."

            Set forth below is the text of Rule 9.02(p) promulgated under the
1933 Act which defines "United States" as follows:

            (p)  "United States" means the United States of America, its
territories and possessions, any State of the United States, and the District
of Columbia.
<PAGE>
                         ELECTION TO EXERCISE WARRANTS

      [NOTE: Unless the transaction has been registered under the 1933
      Act or is exempt from registration thereunder, this Election to
      Exercise Warrants must be executed, and the Warrant Shares must be
      delivered, outside of the U.S., its territories and possessions.]

To:   Epitope, Inc.
      8505 S.W. Creekside Place
      Beaverton, Oregon  97008
      U.S.A.

      The undersigned hereby exercises Warrants represented by the within
Warrant Agreement for ________ shares of the Common Stock of Epitope, Inc.
("Warrant Shares"), and tenders payment herewith in the amount of
U.S. $_________ in accordance with the terms thereof.

      The undersigned hereby certifies that (mark one of the two responses
below):

      ___   (i) It is the sole beneficial owner of the Warrants being
            exercised, (ii) it is not a U.S. person, as defined in Appendix 1
            to the within Warrant Agreement and within the meaning of
            Regulation S promulgated by the U.S. Securities and Exchange
            Commission pursuant to the Securities Act of 1933 ("1933 Act"),
            and (iii) it is not exercising Warrants for the benefit of any
            U.S. person.

                                    --OR--

      ___   The transaction in which the Warrant Shares will be delivered upon
            exercise of the Warrant has been registered under the 1933 Act or
            is exempt from registration thereunder and Epitope, Inc., has been
            provided with a written opinion of counsel to that effect or has
            waived the requirement for an opinion.  A legal opinion regarding
            the registration of the transaction will be obtained at the
            expense of Epitope, Inc., by its designated legal counsel upon
            notice of exercise of the Warrant Agreement by the Warrantholder
            at any time after the effective date of a registration statement
            covering the transaction; any other legal opinion shall be the
            responsibility of the Warrantholder.

      THE UNDERSIGNED HEREBY AGREES NOT TO SELL OR OTHERWISE TRANSFER OR
DISPOSE OF THE WARRANT SHARES FOR A PERIOD ENDING 60 DAYS AFTER THE DATE OF
PURCHASE OF THE WARRANT SHARES.

      Please deliver the certificate and a new Warrant Agreement for the
unexercised Warrants, if any, to:

                        ____________________________________
                        ____________________________________
                        ____________________________________

                                    Warrantholder:__________________________


                                    By___________________________________
                                      Title:
Dated:  ____________, 199_
                                    [Name of Warrantholder must be identical
                                    to name shown in the registry books of the
                                    Company; signature must be guaranteed by a
                                    bank or brokerage firm doing business in
                                    the U.S.]

Warrantholder:    _____________________________________
Address:          _____________________________________
                  _____________________________________
                  _____________________________________
<PAGE>
                              FORM OF ASSIGNMENT

      [NOTE: Unless the transaction has been registered under the 1933
      Act or is exempt from registration thereunder, this Assignment
      must be executed, and the re-issued Warrants must be delivered,
      outside of the U.S., its territories and possessions.]



      FOR VALUE RECEIVED, the undersigned registered owner of this Warrant
Agreement hereby sells, assigns, and transfers to the Assignee(s) named below
all of the rights of the undersigned under the Warrant Agreement, with respect
to Warrants for the number of shares of Common Stock set forth below:


Name of Assignee        Address                              No. of Shares*
- ----------------        -------                              -------------







      *Please note that the minimum denomination in which Warrant Agreements
may be issued is 1,000 shares of Common Stock.



      Dated: ____________, 19___.

                                    Warrantholder:__________________________



                                         By___________________________________
                                                  Title:

                                    [Name of Warrantholder must be identical
                                    to name shown in the registry books of the
                                    Company; signature must be guaranteed by a
                                    bank or brokerage firm doing business in
                                    the U.S.]
<PAGE>


<PAGE>
                                                                   Exhibit 4.4

[Form of Notice -- Technology Transfer Warrants]

                           NOTICE TO WARRANTHOLDERS
                                   REGARDING
                         EXTENSION OF EXPIRATION DATE

THE WARRANTS REFERRED TO BELOW AND THE SHARES OF COMMON STOCK UNDERLYING THE
WARRANTS HAVE NOT BEEN REGISTERED FOR ISSUANCE TO THE WARRANTHOLDERS UNDER THE
SECURITIES ACT OF 1933, AS AMENDED ("1933 ACT"), AND MAY NOT BE OFFERED, SOLD,
PLEDGED, OR OTHERWISE TRANSFERRED AND THE WARRANTS MAY NOT BE EXERCISED UNLESS
THE TRANSACTION IS REGISTERED UNDER THE 1933 ACT AND APPLICABLE STATE
SECURITIES LAWS OR UNLESS AN EXEMPTION FROM REGISTRATION IS AVAILABLE AND THE
ISSUER IS FURNISHED A SATISFACTORY OPINION OF COUNSEL THAT SUCH REGISTRATION
IS NOT REQUIRED.


[Name and Address of Warrantholder]


          Reference is made to the warrants ("Warrants") to purchase common
stock, no par value ("Common Stock"), of Epitope, Inc. (the "Company")
originally issued by the Company on August 1, 1993, and the related Warrant
Agreements ("Warrant Agreements") dated as of the same date containing the
terms of the Warrants.  Capitalized terms used and not otherwise defined
herein have the same meanings as in the Warrant Agreements.

          The Expiration Date for the Warrants, as previously extended, is
March 31, 1997.  The Company hereby further extends the Expiration Date until
September 30, 1997, and will permit all Warrantholders to exercise Warrants
through that date.  Exercise of the Warrants remains subject to the following
conditions:

          (a)   The Exercise Price is $15.50 (the Warrantholders will
                continue to be obligated to pay the Cash Purchase
                Consideration in addition to the Exercise Price); and

          (b)   Common Stock purchased by Warrantholders pursuant to the
                exercise of Warrants may not be sold or otherwise transferred
                or disposed of for a period ending 60 days after the date of
                purchase of such Common Stock.

          Please attach a copy of this notice to your Warrant Agreement.

Dated:  September ___, 1996.

                                    EPITOPE, INC.



                                    By                                        
                                         President
<PAGE>
THESE WARRANTS AND THE SHARES OF COMMON STOCK UNDERLYING THESE WARRANTS HAVE
NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED ("1933 ACT"),
AND MAY NOT BE OFFERED, SOLD, PLEDGED, OR OTHERWISE TRANSFERRED UNLESS THEY
ARE REGISTERED UNDER THE 1933 ACT AND APPLICABLE STATE SECURITIES LAWS OR
UNLESS AN EXEMPTION FROM REGISTRATION IS AVAILABLE AND THE ISSUER IS FURNISHED
A SATISFACTORY OPINION OF COUNSEL THAT SUCH REGISTRATION IS NOT REQUIRED.

COMMON STOCK PURCHASED PURSUANT TO THE EXERCISE OF THESE WARRANTS MAY NOT BE
SOLD OR OTHERWISE TRANSFERRED OR DISPOSED OF FOR A PERIOD OF 60 DAYS AFTER THE
DATE OF PURCHASE OF SUCH COMMON STOCK.


                VOID AFTER 5 P.M., UNITED STATES PACIFIC TIME,
                             ON SEPTEMBER 30, 1997
                   OR SUCH EARLIER DATE AS SPECIFIED HEREIN

                       WARRANTS TO PURCHASE COMMON STOCK

Warrant No. 
                         [Number of Warrants] Warrants


                                 EPITOPE, INC.

                              THIS CERTIFIES THAT

                            [Name of Warrantholder]

or registered assigns is the registered holder of the number of Warrants
(each, a "Warrant," and collectively, "Warrants") set forth above.  Each
Warrant represented by this certificate for Warrants ("Warrant Agreement")
entitles the registered holder thereof (the "Warrantholder") to purchase from
Epitope, Inc., a corporation incorporated under the laws of the state of
Oregon ("Company"), United States of America ("U.S."), one fully paid and
nonassessable share of common stock, no par value, of the Company ("Common
Stock") upon presentation and surrender of this Warrant Agreement with the
accompanying Election to Exercise Warrants duly completed, at any time prior
to 5 P.M., U.S. Pacific time, on the Expiration Date (as defined in
Section 2), at the corporate offices of the Company at 8505 S.W. Creekside
Place, Beaverton, Oregon 97008, or at such other address as may be specified
by the Company pursuant to Section 9, accompanied by payment of the Cash
Purchase Consideration and the Exercise Price (as defined herein) and any
applicable taxes, either in cash in U.S. funds or by certified or official
bank check in U.S. funds payable to the order of the Company.  These Warrants
are issued pursuant to a 1993 Technology Transfer Warrant Issuance Agreement
("Issuance Agreement") among the Company and the Investors described therein
dated as of June 15, 1993.

   Section 1.  Cash Purchase Consideration and Exercise Price.  Upon payment
by the Warrantholder to the Company of U.S. $3.00 for each Warrant desired to
be exercised (the "Cash Purchase Consideration"), each Warrant entitles the
Warrantholder to purchase one share of Common Stock for U.S. $15.50 (the
"Exercise Price"), subject to adjustment as provided herein.

   Section 2.  Expiration.  All Warrants not theretofore exercised shall
expire at 5 p.m., U.S. Pacific time, on the earlier of the following dates
(the "Expiration Date"):  (a) September 30, 1997, and (b) the expiration of
120 days after the first period of 20 consecutive trading days during which
period the average of the high and low sales prices of the Common Stock on the
American Stock Exchange, or any other exchange or national market system on
which the Common Stock is then traded, is at least $30.00.  

   Section 3.  Adjustments of Number and Kind of Shares Purchasable and
Exercise Price.  The number and kind of securities or other property
purchasable upon exercise of a Warrant shall be subject to adjustment from
time to time upon the occurrence, after the date hereof, of the following
events:

        3.1  If the outstanding shares of the Company's Common Stock are
   divided into a greater number of shares or a dividend in Common Stock is
   paid on the Common Stock, the number of shares of Common Stock issuable
   on exercise of the Warrants shall be proportionately increased and the
   Exercise Price in effect immediately prior to such subdivision or at the
   record date of such dividend shall, simultaneously with the
   effectiveness of such subdivision or immediately after the record date
   of such dividend, be proportionately reduced; and, conversely, if the
   outstanding shares of Common Stock are combined into a smaller number of
   shares of Common Stock, the number of shares of Common Stock issuable
   upon exercise of the Warrants shall be proportionately reduced and the
   Exercise Price in effect immediately prior to such combination shall,
   simultaneously with the effectiveness of such combination, be
   proportionately increased.  The increases and reductions provided for in
   this subsection 3.1 shall be made with the intent and, as nearly as
   practicable, the effect that neither the percentage of the total equity
   of the Company issuable on exercise of the Warrants nor the price
   payable for such percentage upon such exercise shall be affected by any
   event described in this subsection 3.1.

        3.2  No adjustment of the Exercise Price will be made if the amount
   of the adjustment is less than U.S. $.01 per share, but in that case any
   adjustment that would otherwise be required to be made will be carried
   forward and will be made at the time of and together with the next
   adjustment of the Exercise Price which, together with any adjustment
   carried forward, amounts to U.S. $.01 per share or more.

        3.3  In case of any change in the Common Stock of the Company
   through merger, consolidation, reclassification, reorganization, partial
   or complete liquidation, or other change in the capital structure of the
   Company (not including a combination of shares or the issuance of
   additional shares of Common Stock by the Company by stock split or stock
   dividend), then, as a condition of the change in the capital structure
   of the Company, provision shall be made so that the holder of this
   Warrant Agreement will have the right thereafter to receive upon the
   exercise of the Warrants the kind and amount of shares of stock or other
   securities or property to which such holder would have been entitled if,
   immediately prior to such merger, consolidation, reclassification,
   reorganization, recapitalization, or other change in the capital
   structure, such holder had held the number of shares of Common Stock
   issuable upon the exercise of the Warrants.  In any such case,
   appropriate adjustment shall be made in the application of the
   provisions set forth herein with respect to the rights and interest
   thereafter of the Warrantholder, to the end that the provisions set
   forth herein shall thereafter be applicable, as nearly as reasonably may
   be, in relation to any shares of stock or other property thereafter
   deliverable upon the exercise of the Warrants.  The Company will not
   permit any change in its capital structure to occur unless the issuer of
   the shares of stock or other securities to be received by the holder of
   this Warrant Agreement, if not the Company, agrees to be bound by and
   comply with the provisions of this Warrant Agreement.

        3.4  When any adjustment is required to be made in the number of
   shares of Common Stock, other securities, or property purchasable upon
   exercise of the Warrants, the Company shall promptly determine the new
   number of shares or other securities or property purchasable upon
   exercise of the Warrants and (a) prepare and retain on file a statement
   describing in reasonable detail the method used in arriving at the new
   number of shares or other securities or property purchasable upon
   exercise of the Warrants and (b) cause a copy of such statement to be
   mailed to the Warrantholder within thirty (30) days after the date when
   the event giving rise to the adjustment occurred.

        3.5  No fractional shares of Common Stock or other securities shall
   be issued in connection with the exercise of any Warrants, but the
   Company shall pay, in lieu of fractional shares, a cash payment therefor
   on the basis of the closing price on a national securities exchange on
   the day immediately prior to exercise or, if the Common Stock or other
   securities are not traded on a national securities exchange on such day,
   on the basis of the fair market value thereof as determined by the board
   of directors of the Company, which determination shall be conclusive.

        3.6  Notwithstanding anything herein to the contrary, there shall
   be no adjustment made hereunder on account of the sale and issuance of
   the shares of Common Stock or other securities purchasable upon exercise
   of the Warrants.

   Section 4.  Rights of Warrantholder as Shareholder.  No holder of this
Warrant Agreement shall, as such, be entitled to vote, receive dividends, or
be deemed the holder of Common Stock or any other securities of the Company
that may at any time be issuable on the exercise hereof for any purpose
whatever, nor shall anything contained herein be construed to confer upon the
holder of this Warrant Agreement, as such, any of the rights of a shareholder
of the Company or any right to vote for the election of directors or upon any
matter submitted to shareholders at any meeting thereof or give or withhold
consent to any corporate action (whether upon any matter submitted to
shareholders at any meeting thereof or otherwise) including, without
limitation, giving or withholding consent to any merger, recapitalization,
issuance of stock, reclassification of stock, exchange of stock, change of
stock to par value, consolidation or conveyance, or to receive notice of
meetings or other actions affecting shareholders or to receive dividends or
subscription rights or other distributions.

   Section 5.  Payment of Certain Taxes and Charges.  The Company shall not be
required to issue or deliver any certificate for shares of Common Stock or
other securities upon the exercise of Warrants evidenced by this Warrant
Agreement or to register the transfer of the Warrants evidenced hereby until
any applicable transfer tax and any other taxes or governmental charges that
the Company may be required by law to collect in respect of such exercise or
transfer shall have been paid, such tax being payable by the holder of this
Warrant Agreement at the time of surrender for exercise or transfer.

   Section 6.  Registration.  The Company has prepared a registration
statement on Form S-3 (the "Registration Statement") under the 1933 Act with
respect to the resale by the Warrantholder of the shares of Common Stock
issued or issuable upon exercise of this Warrant Agreement (the "Warrant
Shares").  As soon as practicable after the original issue date of this
Warrant Agreement (the "Original Issue Date"), the Company shall file the
Registration Statement with the U.S. Securities and Exchange Commission and
shall use its best efforts to cause the Registration Statement to become
effective under the 1933 Act as promptly as practicable after the Original
Issue Date as provided for in, and in accordance with, the terms and
conditions of the Issuance Agreement.  

   Section 7.  Transfer and Exchange.

        7.1  Transfer.  This Warrant Agreement is transferable on the
   registry books of the Company subject to the restrictions on the first
   page hereof and in Section 7.4.  The Company may deem and treat the
   person or entity in whose name this Warrant Agreement is registered as
   the absolute owner hereof (notwithstanding any notation of ownership or
   other writing thereon made by anyone other than the Company) for all
   purposes whatever, and the Company shall not be affected by any notice
   to the contrary.

        7.2  Exchange.  Subject to the provisions of Section 7.4 and the
   restrictions on the first page hereof, this Warrant Agreement is
   exchangeable at the principal office of the Company for Warrant
   Agreements to purchase the same aggregate number of shares of Common
   Stock as are purchasable hereunder, each new Warrant Agreement to
   represent the right to purchase such number of shares as the
   Warrantholder shall designate at the time of such exchange.

        7.3  Securities Act of 1933.  The Warrantholder, by acceptance
   hereof, agrees that this Warrant Agreement and the shares of Common
   Stock issued or issuable upon exercise of this Warrant Agreement may not
   be offered or sold except in compliance with the 1933 Act.  The
   Warrantholder consents to the Company's making a notation on its records
   and on the certificates for any shares of Common Stock issued upon
   exercise hereof in order to implement such restriction on
   transferability.

        7.4  Minimum Warrant Agreement Amount.  Notwithstanding the
   provisions of Section 7.1 and Section 7.2, the Company shall not be
   required to issue a Warrant Agreement for Warrants covering less than
   1,000 shares of Common Stock, except in the case of a partial exercise
   by the Warrantholder of this Warrant Agreement that leaves Warrants
   exercisable to purchase less than 1,000 shares that are to remain
   registered in the name of the exercising Warrantholder, and any
   subsequent partial exercise, transfer, or exchange of such Warrant
   Agreement.

        7.5  No Transfer of Common Stock for 60 Days.  Common Stock purchased
   pursuant to the exercise of these Warrants may not be sold or otherwise
   transferred or disposed of for a period of 60 days after the date of
   purchase of such Common Stock.

   Section 8.  Holdback Agreement.  The Warrantholder, if requested by the
Company and an underwriter of the Company's securities, shall agree not to
sell or otherwise transfer or dispose of any Warrants or Warrant Shares for a
specified period of time (not to exceed 90 days) following the effective date
of a registration statement pursuant to which the Company proposes to sell its
securities to the public generally; provided, however, that all executive
officers and directors of the Company enter into similar agreements.

   Section 9.  Notices.  Any notice, request, or other communication required
or permitted hereunder shall be in writing and shall be deemed to have been
duly given if delivered personally or by certified mail, postage prepaid,
return receipt requested, to: (a) the Company at 8505 S.W. Creekside Place,
Beaverton, Oregon 97008, Attn: Secretary, with a copy to Miller, Nash, Wiener,
Hager & Carlsen, 3500 U.S. Bancorp Tower, 111 S.W. Fifth Avenue, Portland,
Oregon 97204-3699, Attn: Erich W. Merrill, Jr. and (b) to the Warrantholders
at the addresses set forth in the registry books of the Company referred to in
Section 7.1.  Any notice, request, or other communication given by certified
mail shall be deemed given 10 days after the mailing date; notices, requests,
or other communications given in any other manner shall be deemed given when
received.

   Section 10.  Amendment.  This Warrant Agreement may be amended or its
provisions waived only by an instrument in writing signed by the Company and
the Warrantholder as provided in the Issuance Agreement.

   Section 11.  Law Governing.  This Warrant Agreement shall be governed by
and construed in accordance with the laws of the state of Oregon, without
giving effect to choice of laws principles thereof. 

   Dated as of [Date]

                                    EPITOPE, INC.


                                    By                        
                                    
                                    

<PAGE>
                         ELECTION TO EXERCISE WARRANT


To:     Epitope, Inc.
   8505 S.W. Creekside Place
   Beaverton, Oregon  97008
   
        The undersigned hereby exercises the within Warrant Agreement for
________ shares of the Common Stock of Epitope, Inc. ("Warrant Shares"), and
tenders payment herewith in the amount of U.S. $_________ in accordance with
the terms thereof.

        THE UNDERSIGNED HEREBY AGREES NOT TO SELL OR OTHERWISE TRANSFER OR
DISPOSE OF THE WARRANT SHARES FOR A PERIOD ENDING 60 DAYS AFTER THE DATE OF
PURCHASE OF THE WARRANT SHARES.

   Please deliver the certificate and a new Warrant Agreement for the
unexercised Warrants, if any, to:

                  ____________________________________
                  ____________________________________
                  ____________________________________


                                    Warrantholder:___________________________


                                    By_____________________________________
                                       Title:

                                    [Name of Warrantholder must be identical
                                    to name shown in the registry books of the
                                    Company; signature must be guaranteed by a
                                    bank or brokerage firm doing business in
                                    the United States.]

Dated:  ____________, 199__.

Warrantholder:    _____________________________________
Address:          _____________________________________
                  _____________________________________
                  _____________________________________
<PAGE>
                              FORM OF ASSIGNMENT


        FOR VALUE RECEIVED, the undersigned registered owner of this Warrant
Agreement hereby sells, assigns, and transfers to the Assignee(s) named below
all of the rights of the undersigned under the Warrant Agreement, with respect
to Warrants for the number of shares of Common Stock set forth below:


Name of Assignee    Address               No. of Shares*
- ----------------    -------               --------------






   *Please note that the minimum denomination in which Warrant Agreements may
be issued is 1,000 shares of Common Stock.

        The undersigned agrees to furnish to the Company upon request a
satisfactory opinion of counsel to the effect that the transfer requested
above is exempt from the Securities Act of 1933, as amended, and applicable
state securities laws.

   Dated: ______________, 19___.

                                    Warrantholder: _________________________



                                    By _____________________________________
                                       Title:


                                    [Name of Warrantholder must be identical
                                    to name shown in the registry books of the
                                    Company; signature must be guaranteed by a
                                    bank or brokerage firm doing business in
                                    the United States.]


<PAGE>
                                                                  Exhibit 99.1


FOR IMMEDIATE RELEASE                                     Contact:  Mary Hagen
                                                                     Gus Allen
                                                                 (503)641-6115

                     Epitope Reports on Recent Milestones

Beaverton, OR, September 17, 1996:  Epitope, Inc. (AMEX:EPT) today announced
recent events of interest to shareholders.

 ...Sales growth continues for oral specimen collection device

The June 1996 FDA approval of the company's OraSure(R) Western blot HIV
confirmatory test for use with oral specimens, coupled with FDA clearance of
two blood-based home collection HIV test systems, has stimulated demand for
Epitope's oral specimen collection device.  Revenues from shipments of the
device  in the fourth quarter of fiscal 1996, which ends on September 30, are
expected to exceed $1.4 million.  This volume is more than double the amount
shipped in the previous quarter.  To broaden market awareness, Epitope
recently hired three market development managers who will operate from New
York, Illinois and North Carolina.  The newly appointed managers will focus on
promoting use of the EpiScreen(TM) oral specimen HIV-1 testing system by the
life insurance industry.

 ...Progress continues toward approval of over-the counter format of OraSure
device

The company continues to make progress toward FDA approval of an over-the-
counter format of its OraSure(R) oral specimen collection device.  Upon
approval, Epitope will manufacture the devices for over-the-counter marketing
in the U.S. by SmithKline Beecham.  Consumers will collect their own oral
samples with the OraSure device, mail the samples to a clinical laboratory for
HIV testing and call a toll-free number to get their results from a trained
counselor employed by American Social Health Association, the most experienced
AIDS counseling organization in the U.S.

 ...SmithKline Beecham launches OraSure HIV testing system to U.S. professional
market

On August 5, SmithKline Beecham Consumer Healthcare (SB), introduced Epitope's
OraSure HIV-1 testing system in U.S. professional markets.  The product is now
being offered to physicians and other medical professionals by over 3,300
sales representatives.  This marketing effort is supported by an advertising
campaign featuring two-page spreads in prominent medical journals such as The
New England Journal of Medicine and Annals of Internal Medicine.  SB has also
introduced an information phone service, placed informational materials on the
Internet and created a Physicians Referral Network for consumers to identify
doctors in their area who offer confidential HIV testing.
- ---more---
<PAGE>
Epitope/2


 ...SmithKline Beecham commences marketing Orasure for HIV testing in selected
foreign markets

SB has commenced marketing the OraSure oral specimen collection device for use
in HIV detection to professional markets in the European Economic Community,
the United Arab Emirates, four countries in Latin America, and a group of
countries in Central Africa.  Initial shipments to SB for those markets
occurred in July and August.

 ...Vinifera, Inc recapitalized; becomes majority owned subsidiary

In August, Epitope's agricultural biotechnology unit, Agritope, Inc., agreed
to cancel the remaining obligations under a June 1995 agreement to sell its
Vinifera, Inc., grape plant nursery business to VF Holdings, Inc. ("VF"), an
affiliate of a Swiss investment group.  Agritope will dismiss litigation
against VF and its principals in exchange for retaining $830,000 paid by VF
toward obligations under the agreement and issuing 200,000 shares of Series A
Preferred Stock of Vinifera.  Subsequent to the settlement, several private
investors acquired, for $1.3 million, 980,000 shares of Vinifera Series A
Preferred Stock.  As a result of these transactions, Agritope now owns 76.6%
of Vinifera.

 ...Minnesota fresh flower venture formed

In June 1996, an Agritope subsidiary, Agrimax Floral Products, Inc.,
contributed inventory and other operating assets of its St. Paul, Minnesota
fresh flower processing  facility to Petals, USA, Inc., a newly formed
affiliate of a profitable Canadian fresh flower wholesaler, in return for a
19.5% equity interest in the company.  In addition to its interest in the
Minnesota venture, Agrimax holds a 9% equity interest in Tampa, Florida-based
U A F, L.P.

 ...Agritope to develop improved melon varieties in collaboration with
international seed companies 

Using proprietary seed varieties supplied by a French seed company, Clause,
S.A., and its U.S. affiliate, Harris Moran Seed Company, Agritope plans to
utilize its patented ethylene control gene to develop commercial varieties of
melons with controlled ripening and increased post-harvest product life. The
collaboration is a first step towards the potential formation of a joint
venture with producers and marketers for commercialization of melons. 

- ---more---
<PAGE>
Epitope/3


 ...Warrant maturities extended

Epitope has notified holders of warrants to purchase approximately 2 million
shares of the company's common stock that it will extend the deadline to
exercise such warrants to September 30, 1997.  The warrants, which are
exercisable at prices ranging from $16 to $20 per share, were previously set
to expire in September 1996 or March 1997.  If all of the extended warrants
were exercised, Epitope would realize additional proceeds of over $35 million. 
The company has realized over $33 million in proceeds from the exercise of
warrants in the past four years.

Epitope, Inc. is a biotechnology company that develops and markets medical
diagnostic products and, through its agricultural unit, superior new plant
varieties.

This release includes forward-looking statements which are subject to factors
described in Epitope's Annual Report on Form 10-K for the year ended
September 30, 1995, and other documents filed with the Securities and Exchange
Commission.  These factors include unexpected interruption of supply or
manufacturing operations, changes in its marketing partners' strategy or
emphasis, development of competing products, market acceptance of oral
testing, changes in insurance industry practices, unexpected delays in
obtaining state approvals, changes in federal or state law or regulations, and
changes in Epitope's business strategy. 

                                      ###


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