EPITOPE INC/OR/
8-K, 1997-09-15
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                                -----------------

                                    FORM 8-K

                                 CURRENT REPORT

                       Pursuant to Section 13 or 15(d) of
                       the Securities Exchange Act of 1934

                Date of Report (Date of earliest event reported):

                               September 12, 1997

                                -----------------


                                  EPITOPE, INC.
               (Exact name of Registrant as specified in charter)

                                     Oregon
                 (State or other jurisdiction of incorporation)

                                     1-10492
                              (Commission File No.)

                                   93-0779127
                        (IRS Employer Identification No.)

      8505 S.W. Creekside Place
          Beaverton, Oregon                                    97008
(Address of principal executive offices)                     (Zip Code)

               Registrant's telephone number, including area code:

                                 (503) 641-6115




<PAGE>




Item 5.     Other Events.

            On September 12, 1997, Epitope, Inc. ("Epitope") notified holders of
warrants to purchase approximately 2 million shares of Epitope common stock that
it will extend the deadline to exercise the warrants to September 30, 2000.  The
warrants,  which are  exercisable  at prices  ranging from $16 to $20 per share,
were previously set to expire September 30, 1997.

            As previously announced, Epitope's board of directors has approved a
proposal  to spin off  Agritope,  Inc.  Beginning  10 days  after the  spin-off,
Epitope will allow  exercise of the warrants at a reduced  purchase  price.  The
reduced purchase price will be equal to 110 percent of the average closing price
of Epitope  common stock  during the five trading days  beginning on the date of
the spin-off.

Item 7.     Financial Statements, Pro Forma Financial Information and Exhibits.

            (a)   Not applicable.

            (b)   Not applicable.

            (c)   Exhibits.

The  exhibits  filed  herewith  are listed in the exhibit  index  following  the
signature page of this report.




<PAGE>



                                   SIGNATURES

Pursuant  to the  requirements  of the  Securities  Exchange  Act of  1934,  the
Registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.

                              EPITOPE, INC.


Dated:  September 12, 1997    By: /s/ Gilbert N. Miller
                                  Gilbert N. Miller
                                  Executive Vice President and Chief
                                  Financial Officer



<PAGE>


                                 EXHIBIT INDEX


4.1   Notice to  warrantholders  and  current  form of warrant  certificate  for
      warrants issued in September 1991 offering.

4.2   Notice to  warrantholders  and  current  form of warrant  certificate  for
      warrants issued in December 1992 offering.

4.3   Notice to  warrantholders  and  current  form of warrant  certificate  for
      warrants issued in July 1993 offering.

4.4   Notice to  warrantholders  and  current  form of warrant  certificate  for
      warrants issued in August 1993 offering.





                        [Form of Notice -- 1991 Warrants]

                            NOTICE TO WARRANTHOLDERS


THE  WARRANTS  REFERRED TO BELOW AND THE SHARES OF COMMON STOCK  UNDERLYING  THE
WARRANTS HAVE NOT BEEN REGISTERED FOR ISSUANCE TO THE  WARRANTHOLDERS  UNDER THE
UNITED STATES  SECURITIES ACT OF 1933, AS AMENDED  ("1933 ACT"),  AND MAY NOT BE
OFFERED,  SOLD,  TRANSFERRED,  PLEDGED, OR OTHERWISE DISPOSED OF, IN WHOLE OR IN
PART, DIRECTLY OR INDIRECTLY, IN THE UNITED STATES OR TO A U. S. PERSON (AS SUCH
TERMS ARE DEFINED IN  REGULATION S UNDER THE 1933 ACT),  NOR MAY THE WARRANTS BE
EXERCISED IN THE UNITED STATES OR BY OR ON BEHALF OF A U. S. PERSON,  UNLESS (i)
THE TRANSACTION IS REGISTERED  UNDER THE 1933 ACT AND ANY APPLICABLE  SECURITIES
LAWS OF ANY STATE,  TERRITORY OR POSSESSION OF THE UNITED STATES OR THE DISTRICT
OF COLUMBIA ("STATE ACT"), OR (ii) AN EXEMPTION FROM REGISTRATION UNDER THE 1933
ACT OR ANY  APPLICABLE  STATE ACT IS  AVAILABLE  AND THE ISSUER HAS  RECEIVED AN
OPINION OF COUNSEL TO SUCH EFFECT REASONABLY SATISFACTORY TO IT.

[Name and Address of Warrantholder]

            Reference is made to the warrants  ("Warrants")  to purchase  common
stock,  no  par  value  ("Common  Stock"),  of  Epitope,  Inc.  (the  "Company")
originally  issued by the Company on September 26, 1991, and the related Warrant
Agreements ("Warrant Agreements") dated as of the same date containing the terms
of the Warrants.  Capitalized  terms used and not otherwise  defined herein have
the same meanings as in the Warrant Agreements.

            The Expiration  Date for the Warrants,  as previously  extended,  is
September 30, 1997. The Company hereby further extends the Expiration Date until
September 30, 2000.

            The  Company  intends  to  effect  a  spin-off  of  Agritope,   Inc.
("Agritope") by making a dividend  distribution (the "Distribution") of Agritope
common stock to the  Company's  shareholders.  Subject to and effective ten days
after  occurrence of the  Distribution,  the Company will permit exercise of the
Warrants  at a reduced  exercise  price per share  equal to 110  percent  of the
average  closing  price of the Common  Stock on The Nasdaq  Stock Market for the
five consecutive trading days beginning on the date of the Distribution.

            Warrantholders  will  not  receive  Agritope  common  stock  in  the
Distribution  with  respect to shares of Common  Stock  issued upon  exercise of
Warrants after the record date for the Distribution.

            Please attach a copy of this notice to your Warrant Agreement.


Dated:  September 12, 1997.


                                    EPITOPE, INC.


                                    By:-----------------------------------------
                                    Executive Vice President and Chief
                                    Financial Officer





<PAGE>



THESE WARRANTS AND THE SHARES OF COMMON STOCK  UNDERLYING THESE WARRANTS MAY NOT
BE OFFERED, SOLD, TRANSFERRED,  PLEDGED OR OTHERWISE DISPOSED OF, IN WHOLE OR IN
PART, DIRECTLY OR INDIRECTLY,  IN THE UNITED STATES OR TO A U.S. PERSON (AS SUCH
TERMS ARE DEFINED IN REGULATION S UNDER THE  SECURITIES ACT OF 1933, AS AMENDED,
OF THE UNITED  STATES OF AMERICA (THE "1933  ACT")),  NOR MAY THESE  WARRANTS BE
EXERCISED IN THE UNITED STATES OR BY OR ON BEHALF OF A U.S.  PERSON,  UNLESS (i)
THE TRANSACTION IS REGISTERED  UNDER THE 1933 ACT AND ANY APPLICABLE  SECURITIES
LAWS OF ANY STATE,  TERRITORY OR  POSSESSION  OF THE UNITED STATES OF AMERICA OR
THE DISTRICT OF COLUMBIA  ("STATE ACT"), OR (ii) AN EXEMPTION FROM  REGISTRATION
UNDER THE 1933 ACT OR ANY  APPLICABLE  STATE ACT IS AVAILABLE AND THE ISSUER HAS
RECEIVED AN OPINION OF COUNSEL TO SUCH EFFECT REASONABLY SATISFACTORY TO IT.


             VOID AFTER 5 P.M., PACIFIC TIME, ON SEPTEMBER 30, 2000,
                        WARRANTS TO PURCHASE COMMON STOCK

Warrant No. ___                  ___ Warrants


                                 EPITOPE, INC.

                              THIS CERTIFIES THAT

                            [Name of warrantholder]

or  registered  assigns,  is the  registered  holder of the  number of  Warrants
("Warrants")  set forth  above.  Each Warrant  entitles the holder  thereof (the
"Warrantholder")  to purchase  from Epitope,  Inc., a  corporation  incorporated
under the laws of the state of Oregon ("Company"), United States of America, one
fully paid and nonassessable share of common stock, no par value, of the Company
("Common Stock") upon  presentation and surrender of this Warrant Agreement with
the instructions for the registration and delivery of Common Stock filled in, at
any time prior to 5 P.M.,  Pacific time, on September 30, 2000, at the corporate
offices of the Company at 8505 S.W.  Creekside Place,  Beaverton,  Oregon 97008,
United  States of America,  or at such other  address as may be specified by the
Company  pursuant to Section ,  accompanied by payment of the Exercise Price (as
defined  herein) and any  applicable  taxes,  either in cash or by  certified or
official bank check,  payable in lawful money of the United States of America to
the order of the Company.

      Section 1. Exercise  Price.  Each Warrant  entitles the  Warrantholder  to
purchase one share of Common  Stock for U.S.  $______  (the  "Exercise  Price"),
subject to adjustment as provided herein.

      Section 2. Expiration. All Warrants not theretofore exercised shall expire
at 5 p.m., Pacific time, on September 30, 2000 (the "Expiration Date").

      Section  3.  Adjustments  of  Number  and Kind of Shares  Purchasable  and
Exercise Price. The number and kind of securities or other property  purchasable
upon exercise of a Warrant shall be subject to adjustment from time to time upon
the occurrence, after the date hereof, of the following events:

            3.1 If the  outstanding  shares of the  Company's  Common  Stock are
      divided into a greater  number of shares or a dividend in stock is paid on
      the  Common  Stock,  the  number of shares of  Common  Stock  issuable  on
      exercise  of the  Warrants  shall  be  proportionately  increased  and the
      Exercise Price in effect  immediately  prior to such subdivision or at the
      record date of such dividend shall,  simultaneously with the effectiveness
      of such subdivision or immediately after the record date of such dividend,
      be proportionately reduced; and, conversely,  if the outstanding shares of
      Common Stock are combined into a smaller number of shares of Common Stock,
      the



                                      - 1 -


<PAGE>



      number of shares of Common Stock  issuable  upon  exercise of the Warrants
      shall  be  proportionately  reduced  and  the  Exercise  Price  in  effect
      immediately  prior  to such  combination  shall,  simultaneously  with the
      effectiveness  of such  combination,  be  proportionately  increased.  The
      increases and reductions provided for in this subsection 3.1 shall be made
      with the intent and, as nearly as practicable, the effect that neither the
      percentage of the total equity of the Company  issuable on exercise of the
      Warrants  nor the price  payable for such  percentage  upon such  exercise
      shall be affected by any event described in this subsection 3.1.

            3.2 No adjustment  of the Exercise  Price will be made if the amount
      of the  adjustment  is less than one cent per share,  but in that case any
      adjustment  that would  otherwise  be  required to be made will be carried
      forward  and  will be  made at the  time of and  together  with  the  next
      adjustment  of the Exercise  Price  which,  together  with any  adjustment
      carried forward, amounts to one cent per share or more.

            3.3 In case of any change in the Common Stock of the Company through
      merger,  consolidation,   reclassification,   reorganization,  partial  or
      complete  liquidation,  or other  change in the capital  structure  of the
      Company  (not  including  a  combination  of  shares  or the  issuance  of
      additional  shares of Common  Stock by the Company by stock split or stock
      dividend),  then, as a condition of the change in the capital structure of
      the  Company,  provision  shall be made so that the holder of this Warrant
      Agreement  will have the right  thereafter to receive upon the exercise of
      the Warrants the kind and amount of shares of stock or other securities or
      property to which such holder  would have been  entitled  if,  immediately
      prior to such  merger,  consolidation,  reclassification,  reorganization,
      recapitalization,  or other change in the capital  structure,  such holder
      had held the number of shares of Common Stock  issuable  upon the exercise
      of the Warrants. In any such case, appropriate adjustment shall be made in
      the  application  of the  provisions  set forth herein with respect to the
      rights and interest  thereafter of the Warrantholder,  to the end that the
      provisions set forth herein shall  thereafter be applicable,  as nearly as
      reasonably  may be, in relation  to any shares of stock or other  property
      thereafter deliverable upon the exercise of the Warrants. The Company will
      not permit any change in its capital  structure to occur unless the issuer
      of the shares of stock or other securities to be received by the holder of
      this  Warrant  Agreement,  if not the  Company,  agrees to be bound by and
      comply with the provisions of this Warrant Agreement.

            3.4 When any  adjustment  is  required  to be made in the  number of
      shares of Common Stock, other securities, or the property purchasable upon
      exercise of the  Warrants,  the Company shall  promptly  determine the new
      number of shares or other securities or property purchasable upon exercise
      of the Warrants and (i) prepare and retain on file a statement  describing
      in  reasonable  detail the method  used in  arriving  at the new number of
      shares or other  securities or property  purchasable  upon exercise of the
      Warrants  and (ii)  cause a copy of such  statement  to be  mailed  to the
      Warrantholder within thirty (30) days after the date when the event giving
      rise to the adjustment occurred.

            3.5 No fractional shares of Common Stock or other securities will be
      issued in connection  with the exercise of any  Warrants,  but the Company
      shall pay, in lieu of fractional  shares,  a cash payment  therefor on the
      basis of the closing  price on a national  securities  exchange on the day
      immediately  prior to exercise or if the Common Stock or other  securities
      are not traded on a national securities exchange on such day, on the basis
      of the fair market value  thereof as  determined by the board of directors
      of the Company, which determination shall be conclusive.

            3.6 Notwithstanding  anything herein to the contrary, there shall be
      no  adjustment  made  hereunder on account of the sale and issuance of the
      shares of Common Stock or other  securities  purchasable  upon exercise of
      the Warrants.




                                      - 2 -

<PAGE>



      Section  4.  Rights of  Warrantholder  as  Shareholder.  No holder of this
Warrant Agreement shall, as such, be entitled to vote, receive dividends,  or be
deemed the holder of Common  Stock or any other  securities  of the Company that
may at any time be issuable on the exercise hereof for any purpose whatever, nor
shall anything  contained  herein be construed to confer upon the holder of this
Warrant Agreement, as such, any of the rights of a shareholder of the Company or
any right to vote for the election of directors or upon any matter  submitted to
shareholders at any meeting thereof or give or withhold consent to any corporate
action (whether upon any matter submitted to shareholders at any meeting thereof
or otherwise)  including,  without limitation,  giving or withholding consent to
any  merger,  recapitalization,  issuance of stock,  reclassification  of stock,
change  of par  value  or  change  of stock to no par  value,  consolidation  or
conveyance,  or to  receive  notice  of  meetings  or  other  actions  affecting
shareholders  or  to  receive   dividends  or   subscription   rights  or  other
distributions.

      Section 5. Payment of Certain Taxes and Charges.  The Company shall not be
required to issue or deliver any certificate for shares of Common Stock or other
securities upon the exercise of Warrants  evidenced by this Warrant Agreement or
to register the transfer of the Warrants  evidenced  hereby until any applicable
transfer tax and any other taxes or governmental charges that the Company may be
required by law to collect in respect of such  exercise  or transfer  shall have
been paid, such tax being payable by the holder of this Warrant Agreement at the
time of surrender for exercise or transfer.

      Section 6.  Registration.

            6.1 Registration Statement.  The Company has prepared a registration
      statement on Form S-3 (the  "Registration  Statement")  under the 1933 Act
      with respect to transfer by the  Warrantholder  of the Warrants covered by
      this Warrant  Agreement and the re-sale by the Warrantholder of the shares
      of Common Stock issued or issuable upon exercise of this Warrant Agreement
      (the "Warrant  Shares").  A soon as  practicable  after the original issue
      date of this Warrant  Agreement (the "Original  Issue Date"),  the Company
      shall file the  Registration  Statement with the United States  Securities
      and  Exchange  Commission  and  shall  use its best  efforts  to cause the
      Registration  Statement to become effective under the 1933 Act as promptly
      as  practicable  after the Original  Issue Date. If required by applicable
      law,  the  Company  shall  furnish  to  the  initial   Warrantholder  such
      reasonable  number of  copies  of a  prospectus,  in  conformity  with the
      requirements  of the 1933 Act, and any amendments or  supplements  thereto
      and such other documents as such  Warrantholder may reasonably  request in
      order to facilitate  the  disposition  of the Warrants and Warrant  Shares
      (the  "Securities")  after the  Registration  Statement  has been declared
      effective.  The  Company  shall use  reasonable  efforts (i) to notify the
      initial  Warrantholder  when a prospectus  relating to the  Securities  is
      required to be  delivered  under the 1933 Act,  (ii) to notify the initial
      Warrantholder  of the  happening  of any  event as a result  of which  the
      prospectus  included  in the  Registration  Statement,  as then in effect,
      includes  an  untrue  statement  of a  material  fact or  omits to state a
      material  fact  required  to be stated  therein or  necessary  to make the
      statements  therein not misleading in the light of the circumstances  then
      existing, (iii) to promptly file such amendments and supplements as may be
      required  on account of such  event,  and (iv) to use its best  efforts to
      cause each such amendment and supplement to become effective.  The initial
      Warrantholder  shall not effect sales of the  Securities  after receipt of
      notice from the Company that any such  amendment or supplement is required
      on account of any such event,  until the amendment or  supplement  becomes
      effective.  The Company's obligations under this Section shall expire five
      years after the  Original  Issue Date or on any earlier  date by which the
      initial  Warrantholder  has sold the  Securities or on and after which the
      initial  Warrantholder may sell the Securities without  registration under
      the 1933 Act.

            6.2 Warrantholder Information.  It shall be a condition precedent to
      the obligations of the Company to take any action pursuant to this Section
      that Warrantholder shall furnish to the Company such information regarding
      itself,  the  Securities,  and the intended  method of  disposition of the
      Securities as the Company shall reasonably request.




                                      - 3 -


<PAGE>



            6.3  Expenses of  Registration.  The Company  shall pay all expenses
      (other than  underwriting  discounts and  commissions,  transfer taxes, if
      any, and fees and disbursements of counsel to the Warrantholder)  incurred
      in connection with the Registration Statement.

      Section 7.  Transfer and Exchange.

            7.1 Transfer. This Warrant Agreement is transferable on the registry
      books of the Company subject to the  restrictions on the first page hereof
      and in Section . The  Company  may deem and treat the person in whose name
      this  Warrant  Agreement  is  registered  as  the  absolute  owner  hereof
      (notwithstanding  any notation of ownership or other writing  thereon made
      by anyone  other than the  Company)  for all  purposes  whatever,  and the
      Company shall not be affected by any notice to the contrary.

            7.2  Exchange.  Subject to the  provisions of Section , this Warrant
      Agreement  is  exchangeable  at the  principal  office of the  Company for
      Warrant  Agreements  to purchase  the same  aggregate  number of shares of
      Common Stock as are purchasable  hereunder,  each new Warrant Agreement to
      represent the right to purchase such number of shares as the Warrantholder
      shall designate at the time of such exchange.

            7.3 Securities Act of 1933. The Warrantholder, by acceptance hereof,
      agrees that this Warrant  Agreement  and the shares of Common Stock issued
      or issuable upon exercise of this Warrant  Agreement may not be offered or
      sold except in compliance with the 1933 Act. The Warrantholder consents to
      the Company's making a notation on its records and on the certificates for
      any  shares  of  Common  Stock  issued  upon  exercise  hereof in order to
      implement such restriction on transferability.

            7.4 Minimum Warrant Agreement Amount. Notwithstanding the provisions
      of Section 7.1 and Section 7.2, the Company shall not be required to issue
      a Warrant Agreement for Warrants covering less than 1,000 shares of Common
      Stock,  except in the case of a partial  exercise by the  Warrantholder of
      this Warrant  Agreement that leaves Warrants  exercisable to purchase less
      than  1,000  shares  that  are to  remain  registered  in the  name of the
      exercising Warrantholder,  and any subsequent partial exercise,  transfer,
      or exchange of such Warrant Agreement.

      Section 8.  Lockup  Agreement.  The  Warrantholder,  if  requested  by the
Company and an underwriter of the Company's securities,  shall agree not to sell
or otherwise transfer or dispose of any Warrant Shares for a specified period of
time (not to exceed 90 days)  following  the  effective  date of a  registration
statement  pursuant to which the Company  proposes to sell its securities to the
public generally;  provided,  however, that all executive officers and directors
of the Company enter into similar agreements.

      Section 9. Notices. All notices and other communications given pursuant to
this  Warrant  Agreement  shall be in writing.  Notices to the Company  shall be
deemed  to  have  been  given  when  received  by the  Company.  Notices  to the
Warrantholder  shall be deemed to have been given when personally  delivered or,
if mailed, upon deposit in the United States mails,  postage prepaid,  addressed
at the address  provided to the Company and set forth in the Company's  registry
books.  Notices  mailed to the  Warrantholder  shall be sent via  airmail if the
Warrantholder's  address is outside  the United  States.  Notices to the Company
should be addressed as follows:

                  Epitope, Inc.
                  8505 S.W. Creekside Place
                  Beaverton, Oregon  97008
                  Attention:  President

            With a copy (which shall not constitute notice) to:



                                      - 4 -

<PAGE>




                  Miller, Nash, Wiener, Hager & Carlsen LLP
                  3500 U. S. Bancorp Tower
                  111 S.W. Fifth Avenue
                  Portland, Oregon  97204
                  Attention:  Erich W. Merrill, Jr.

Such  addresses  for  notices may be changed by any party by notice to the other
party pursuant to this Section 9.

      Section 10.  Amendment.  This Warrant  Agreement may be amended only by an
instrument in writing signed by the Company and the Warrantholder.

      Section 11. Law Governing.  This Warrant  Agreement shall be construed and
enforced  in  accordance  with and  governed by the laws of the state of Oregon,
United States of America,  applicable to contracts to be performed in such state
between residents thereof,  without regard to the conflicts of law provisions of
such state.

      Dated as of ------------------.

                                    EPITOPE, INC.


                                    By------------------------------------------

                                    Attest:


                                    By------------------------------------------





                                      - 5 -




<PAGE>



                          ELECTION TO EXERCISE WARRANT

      [NOTE:  Unless the Warrant Shares have been registered  under the 1933 Act
      or are exempt  from  registration  thereunder,  this  Election to Exercise
      Warrant  must be  executed,  and the  Warrant  Shares  must be  delivered,
      outside of the United States of America, its territories and possessions.]

To:   Epitope, Inc.
      8505 Creekside Place
      Beaverton, Oregon  97008
      United States of America

            The undersigned  hereby  exercises the within Warrant  Agreement for
________  shares of the Common  Stock of  Epitope,  Inc.,  and  tenders  payment
herewith in the amount of U.S. $_________ in accordance with the terms thereof.

            The undersigned hereby certifies that (mark one of the two responses
below):

            ___   (i) It is the  sole  beneficial  owner of the  Warrants  being
                  exercised, (ii) it is not a U.S. person, within the meaning of
                  Regulation S promulgated  by the United States  Securities and
                  Exchange  Commission  pursuant to the  Securities  Act of 1933
                  ("1933 Act"), and (iii) it is not exercising  Warrants for the
                  benefit of any U.S. person.

                                     --OR--

            ___   The  securities  to be delivered  upon exercise of the Warrant
                  ("Warrant  Shares") have been registered under the 1933 Act or
                  are exempt from registration thereunder and Epitope, Inc., has
                  been  provided  with a  written  opinion  of  counsel  to that
                  effect.  [A legal opinion  regarding the  registration  of the
                  Warrant  Shares  will be  obtained  at the expense of Epitope,
                  Inc., by its designated  legal counsel upon notice of exercise
                  of the  Warrant  Agreement  by the  Warrantholder  at any time
                  after the effective date of a registration  statement covering
                  the  Warrant  Shares;  any other  legal  opinion  shall be the
                  responsibility of the Warrantholder.]

      Please  deliver  the  certificate  and a new  Warrant  Agreement  for  the
unexercised Warrants, if any, to:

                        ------------------------------------
                        ------------------------------------
                        ------------------------------------

                                          --------------------------------------
                                          Name and Title:

Dated:  ---------------, 199--

Warrantholder: --------------------------------
Address:       --------------------------------
               --------------------------------
               --------------------------------



<PAGE>


                               FORM OF ASSIGNMENT

      [NOTE:  Unless the Warrants have been registered under the 1933 Act or are
      exempt from registration thereunder, this Assignment must be executed, and
      the re-issued Warrants must be delivered,  outside of the United States of
      America, its territories and possessions.]



      FOR VALUE  RECEIVED,  the  undersigned  registered  owner of this  Warrant
Agreement hereby sells,  assigns, and transfers unto the Assignee(s) named below
all of the rights of the undersigned under the Warrant  Agreement,  with respect
to Warrants for the number of shares of Common Stock set forth below:


Name of Assignee                    Address                     No. of Shares*
- ----------------                    -------                     --------------








      *Please note that the minimum denomination in which Warrant Agreements may
be issued is 1,000 shares of Common Stock.



      Dated: --------------, 19--.

                                    Warrantholder:------------------------------



                                    By------------------------------------------
                                       Title:

                                    [Name of warrantholder  must be identical to
                                    name  shown  in the  registry  books  of the
                                    Company;  signature  must be guaranteed by a
                                    bank or brokerage firm doing business in the
                                    United States.]


                        [Form of Notice -- 1992 Warrants]

                            NOTICE TO WARRANTHOLDERS


THE  WARRANTS  REFERRED TO BELOW AND THE SHARES OF COMMON STOCK  UNDERLYING  THE
WARRANTS HAVE NOT BEEN REGISTERED FOR ISSUANCE TO THE  WARRANTHOLDERS  UNDER THE
UNITED STATES  SECURITIES ACT OF 1933, AS AMENDED  ("1933 ACT"),  AND MAY NOT BE
OFFERED,  SOLD,  TRANSFERRED,  PLEDGED, OR OTHERWISE DISPOSED OF, IN WHOLE OR IN
PART, DIRECTLY OR INDIRECTLY, IN THE UNITED STATES OR TO A U. S. PERSON (AS SUCH
TERMS ARE DEFINED IN  REGULATION S UNDER THE 1933 ACT),  NOR MAY THE WARRANTS BE
EXERCISED IN THE UNITED STATES OR BY OR ON BEHALF OF A U. S. PERSON,  UNLESS (i)
THE TRANSACTION IS REGISTERED  UNDER THE 1933 ACT AND ANY APPLICABLE  SECURITIES
LAWS OF ANY STATE,  TERRITORY OR POSSESSION OF THE UNITED STATES OR THE DISTRICT
OF COLUMBIA ("STATE ACT"), OR (ii) AN EXEMPTION FROM REGISTRATION UNDER THE 1933
ACT OR ANY  APPLICABLE  STATE ACT IS  AVAILABLE  AND THE ISSUER HAS  RECEIVED AN
OPINION OF COUNSEL TO SUCH EFFECT REASONABLY SATISFACTORY TO IT.

[Name and Address of Warrantholder]

            Reference is made to the warrants  ("Warrants")  to purchase  common
stock,  no  par  value  ("Common  Stock"),  of  Epitope,  Inc.  (the  "Company")
originally  issued by the Company on December 23, 1992, and the related  Warrant
Agreements ("Warrant Agreements") dated as of the same date containing the terms
of the Warrants.  Capitalized  terms used and not otherwise  defined herein have
the same meanings as in the Warrant Agreements.

            The Expiration  Date for the Warrants,  as previously  extended,  is
September 30, 1997. The Company hereby further extends the Expiration Date until
September 30, 2000.

            The  Company  intends  to  effect  a  spin-off  of  Agritope,   Inc.
("Agritope") by making a dividend  distribution (the "Distribution") of Agritope
common stock to the  Company's  shareholders.  Subject to and effective ten days
after  occurrence of the  Distribution,  the Company will permit exercise of the
Warrants  at a reduced  exercise  price per share  equal to 110  percent  of the
average  closing  price of the Common  Stock on The Nasdaq  Stock Market for the
five consecutive trading days beginning on the date of the Distribution.

            Warrantholders  will  not  receive  Agritope  common  stock  in  the
Distribution  with  respect to shares of Common  Stock  issued upon  exercise of
Warrants after the record date for the Distribution.

            Please attach a copy of this notice to your Warrant Agreement.


Dated:  September 12, 1997.

                   EPITOPE, INC.


                   By ----------------------------------------------------------
                        Executive Vice President and Chief Financial Officer




<PAGE>



THESE WARRANTS AND THE SHARES OF COMMON STOCK UNDERLYING THESE WARRANTS HAVE NOT
BEEN  REGISTERED  UNDER THE UNITED  STATES  SECURITIES  ACT OF 1933,  AS AMENDED
("1933 ACT"), AND MAY NOT BE OFFERED, SOLD,  TRANSFERRED,  PLEDGED, OR OTHERWISE
DISPOSED OF, IN WHOLE OR IN PART,  DIRECTLY OR INDIRECTLY,  IN THE UNITED STATES
OR TO A U.S.  PERSON (AS SUCH TERMS ARE DEFINED IN  REGULATION  S UNDER THE 1933
ACT),  NOR MAY THESE  WARRANTS  BE  EXERCISED  IN THE UNITED  STATES OR BY OR ON
BEHALF OF A U.S. PERSON, UNLESS (i) THE TRANSACTION IS REGISTERED UNDER THE 1933
ACT AND ANY APPLICABLE SECURITIES LAWS OF ANY STATE,  TERRITORY OR POSSESSION OF
THE  UNITED  STATES  OR THE  DISTRICT  OF  COLUMBIA  ("STATE  ACT"),  OR (ii) AN
EXEMPTION FROM  REGISTRATION  UNDER THE 1933 ACT OR ANY APPLICABLE  STATE ACT IS
AVAILABLE  AND THE ISSUER  HAS  RECEIVED  AN  OPINION OF COUNSEL TO SUCH  EFFECT
REASONABLY SATISFACTORY TO IT.

COMMON STOCK  PURCHASED  PURSUANT TO THE  EXERCISE OF THESE  WARRANTS MAY NOT BE
SOLD OR OTHERWISE  TRANSFERRED  OR DISPOSED OF FOR A PERIOD OF 60 DAYS AFTER THE
DATE OF PURCHASE OF SUCH COMMON STOCK

                 VOID AFTER 5 P.M., UNITED STATES PACIFIC TIME,
                              ON SEPTEMBER 30, 2000
                    OR SUCH EARLIER DATE AS SPECIFIED HEREIN

                        WARRANTS TO PURCHASE COMMON STOCK

Warrant No. ___             ______________ Warrants


                                  EPITOPE, INC.

THIS CERTIFIES THAT

                             [Name of warrantholder]

or registered assigns, is the registered holder of the number of Warrants (each,
a  "Warrant,"  and  collectively,  "Warrants")  set forth  above.  Each  Warrant
represented by this certificate for Warrants ("Warrant  Agreement") entitles the
registered holder thereof (the "Warrantholder") to purchase from Epitope,  Inc.,
a corporation  incorporated  under the laws of the state of Oregon  ("Company"),
United States of America  ("U.S."),  one fully paid and  nonassessable  share of
common stock, no par value, of the Company  ("Common  Stock") upon  presentation
and  surrender  of this  Warrant  Agreement  with the  accompanying  Election to
Exercise  Warrants duly  completed,  at any time prior to 5 P.M.,  U.S.  Pacific
time, on the Expiration Date (as defined in Section 2), at the corporate offices
of the Company at 8505 S.W. Creekside Place, Beaverton, Oregon 97008, or at such
other  address  as may be  specified  by  the  Company  pursuant  to  Section  ,
accompanied  by  payment  of the  Exercise  Price (as  defined  herein)  and any
applicable taxes,  either in cash in U.S. funds or by certified or official bank
check in U.S.  funds  payable to the order of the  Company.  These  Warrants are
issued pursuant to a Warrant Purchase Agreement ("Purchase Agreement") among the
Company and the Investors described therein dated as of November 25, 1992.

      Section 1. Exercise  Price.  Each Warrant  entitles the  Warrantholder  to
purchase  one share of Common  Stock for U.S.  $_____  (the  "Exercise  Price"),
subject to adjustment as provided herein.

      Section 2. Expiration. All Warrants not theretofore exercised shall expire
at 5 p.m.,  U.S.  Pacific  time,  on the  earlier  of the  following  dates (the
"Expiration  Date"):  (a) September 30, 2000 and (b) the  expiration of 120 days
after the first  period of 20  consecutive  trading days during which period the
average of the high and low sales prices of the Common Stock on The Nasdaq Stock
Market or any other exchange or national market system on which the Common Stock
is then traded, is at least $30.00.



                                      - 1 -

<PAGE>



      Section  3.  Adjustments  of  Number  and Kind of Shares  Purchasable  and
Exercise Price. The number and kind of securities or other property  purchasable
upon exercise of a Warrant shall be subject to adjustment from time to time upon
the occurrence, after the date hereof, of the following events:

            3.1 If the  outstanding  shares of the  Company's  Common  Stock are
      divided  into a greater  number of shares or a dividend in Common Stock is
      paid on the Common Stock, the number of shares of Common Stock issuable on
      exercise  of the  Warrants  shall  be  proportionately  increased  and the
      Exercise Price in effect  immediately  prior to such subdivision or at the
      record date of such dividend shall,  simultaneously with the effectiveness
      of such subdivision or immediately after the record date of such dividend,
      be proportionately reduced; and, conversely,  if the outstanding shares of
      Common Stock are combined into a smaller number of shares of Common Stock,
      the  number of  shares  of Common  Stock  issuable  upon  exercise  of the
      Warrants shall be proportionately reduced and the Exercise Price in effect
      immediately  prior  to such  combination  shall,  simultaneously  with the
      effectiveness  of such  combination,  be  proportionately  increased.  The
      increases and reductions provided for in this subsection 3.1 shall be made
      with the intent and, as nearly as practicable, the effect that neither the
      percentage of the total equity of the Company  issuable on exercise of the
      Warrants  nor the price  payable for such  percentage  upon such  exercise
      shall be affected by any event described in this subsection 3.1.

            3.2 No adjustment  of the Exercise  Price will be made if the amount
      of the  adjustment is less than U.S. $.01 per share,  but in that case any
      adjustment  that would  otherwise  be  required to be made will be carried
      forward  and  will be  made at the  time of and  together  with  the  next
      adjustment  of the Exercise  Price  which,  together  with any  adjustment
      carried forward, amounts to U.S. $.01 per share or more.

            3.3 In case of any change in the Common Stock of the Company through
      merger,  consolidation,   reclassification,   reorganization,  partial  or
      complete  liquidation,  or other  change in the capital  structure  of the
      Company  (not  including  a  combination  of  shares  or the  issuance  of
      additional  shares of Common  Stock by the Company by stock split or stock
      dividend),  then, as a condition of the change in the capital structure of
      the  Company,  provision  shall be made so that the holder of this Warrant
      Agreement  will have the right  thereafter to receive upon the exercise of
      the Warrants the kind and amount of shares of stock or other securities or
      property to which such holder  would have been  entitled  if,  immediately
      prior to such  merger,  consolidation,  reclassification,  reorganization,
      recapitalization,  or other change in the capital  structure,  such holder
      had held the number of shares of Common Stock  issuable  upon the exercise
      of the Warrants. In any such case, appropriate adjustment shall be made in
      the  application  of the  provisions  set forth herein with respect to the
      rights and interest  thereafter of the Warrantholder,  to the end that the
      provisions set forth herein shall  thereafter be applicable,  as nearly as
      reasonably  may be, in relation  to any shares of stock or other  property
      thereafter deliverable upon the exercise of the Warrants. The Company will
      not permit any change in its capital  structure to occur unless the issuer
      of the shares of stock or other securities to be received by the holder of
      this  Warrant  Agreement,  if not the  Company,  agrees to be bound by and
      comply with the provisions of this Warrant Agreement.

            3.4 When any  adjustment  is  required  to be made in the  number of
      shares of Common Stock,  other  securities,  or property  purchasable upon
      exercise of the  Warrants,  the Company shall  promptly  determine the new
      number of shares or other securities or property purchasable upon exercise
      of the Warrants and (a) prepare and retain on file a statement  describing
      in  reasonable  detail the method  used in  arriving  at the new number of
      shares or other  securities or property  purchasable  upon exercise of the
      Warrants  and  (b)  cause a copy of such  statement  to be  mailed  to the
      Warrantholder within thirty (30) days after the date when the event giving
      rise to the adjustment occurred.



                                      - 2 -

<PAGE>



            3.5 No fractional  shares of Common Stock or other  securities shall
      be issued in connection with the exercise of any Warrants, but the Company
      shall pay, in lieu of fractional  shares,  a cash payment  therefor on the
      basis of the closing  price on a national  securities  exchange on the day
      immediately  prior to exercise or, if the Common Stock or other securities
      are not traded on a national securities exchange on such day, on the basis
      of the fair market value  thereof as  determined by the board of directors
      of the Company, which determination shall be conclusive.

            3.6 Notwithstanding  anything herein to the contrary, there shall be
      no  adjustment  made  hereunder on account of the sale and issuance of the
      shares of Common Stock or other  securities  purchasable  upon exercise of
      the Warrants.

      Section  4.  Rights of  Warrantholder  as  Shareholder.  No holder of this
Warrant Agreement shall, as such, be entitled to vote, receive dividends,  or be
deemed the holder of Common  Stock or any other  securities  of the Company that
may at any time be issuable on the exercise hereof for any purpose whatever, nor
shall anything  contained  herein be construed to confer upon the holder of this
Warrant Agreement, as such, any of the rights of a shareholder of the Company or
any right to vote for the election of directors or upon any matter  submitted to
shareholders at any meeting thereof or give or withhold consent to any corporate
action (whether upon any matter submitted to shareholders at any meeting thereof
or otherwise)  including,  without limitation,  giving or withholding consent to
any  merger,  recapitalization,  issuance of stock,  reclassification  of stock,
exchange of stock, change of stock to par value, consolidation or conveyance, or
to receive  notice of meetings or other  actions  affecting  shareholders  or to
receive dividends or subscription rights or other distributions.

      Section 5. Payment of Certain Taxes and Charges.  The Company shall not be
required to issue or deliver any certificate for shares of Common Stock or other
securities upon the exercise of Warrants  evidenced by this Warrant Agreement or
to register the transfer of the Warrants  evidenced  hereby until any applicable
transfer tax and any other taxes or governmental charges that the Company may be
required by law to collect in respect of such  exercise  or transfer  shall have
been paid, such tax being payable by the holder of this Warrant Agreement at the
time of surrender for exercise or transfer.

      Section 6. Registration. The Company has prepared a registration statement
on Form S-3 (the  "Registration  Statement")  under the 1933 Act with respect to
transfer by the  Warrantholder of the Warrants covered by this Warrant Agreement
and the re-sale by the  Warrantholder  of the shares of Common  Stock  issued or
issuable upon exercise of this Warrant Agreement (the "Warrant Shares"). As soon
as  practicable  after the original  issue date of this Warrant  Agreement  (the
"Original Issue Date"),  the Company shall file the Registration  Statement with
the U.S.  Securities  and Exchange  Commission and shall use its best efforts to
cause  the  Registration  Statement  to become  effective  under the 1933 Act as
promptly as practicable after the Original Issue Date as provided for in, and in
accordance with, the terms and conditions of the Purchase Agreement.

      Section 7.  Transfer and Exchange.

            7.1 Transfer. This Warrant Agreement is transferable on the registry
      books of the Company subject to the  restrictions on the first page hereof
      and in  Section . The  Company  may deem and treat the person or entity in
      whose name this Warrant  Agreement  is  registered  as the absolute  owner
      hereof (notwithstanding any notation of ownership or other writing thereon
      made by anyone other than the Company) for all purposes whatever,  and the
      Company shall not be affected by any notice to the contrary.

            7.2  Exchange.   Subject  to  the  provisions  of  Section  and  the
      restrictions  on  the  first  page  hereof,   this  Warrant  Agreement  is
      exchangeable at the principal office of the Company for Warrant Agreements
      to purchase  the same  aggregate  number of shares of Common  Stock as are
      purchasable  hereunder,  each new Warrant Agreement to represent the right
      to purchase such number of shares as the Warrantholder  shall designate at
      the time of such exchange.



                                      - 3 -

<PAGE>



            7.3 Securities Act of 1933. The Warrantholder, by acceptance hereof,
      agrees that this Warrant  Agreement  and the shares of Common Stock issued
      or issuable upon exercise of this Warrant  Agreement may not be offered or
      sold except in compliance with the 1933 Act. The Warrantholder consents to
      the Company's making a notation on its records and on the certificates for
      any  shares  of  Common  Stock  issued  upon  exercise  hereof in order to
      implement such restriction on transferability.

            7.4 Minimum Warrant Agreement Amount. Notwithstanding the provisions
      of Section  and  Section , the  Company  shall not be  required to issue a
      Warrant  Agreement for Warrants  covering less than 1,000 shares of Common
      Stock,  except in the case of a partial  exercise by the  Warrantholder of
      this Warrant  Agreement that leaves Warrants  exercisable to purchase less
      than  1,000  shares  that  are to  remain  registered  in the  name of the
      exercising Warrantholder,  and any subsequent partial exercise,  transfer,
      or exchange of such Warrant Agreement.

            7.5 No Transfer of Common Stock for 60 Days.  Common Stock purchased
      pursuant to the  exercise of these  Warrants  may not be sold or otherwise
      transferred  or  disposed  of for a period  of 60 days  after  the date of
      purchase of such Common Stock.

      Section 8.  Holdback  Agreement.  The  Warrantholder,  if requested by the
Company and an underwriter of the Company's securities,  shall agree not to sell
or  otherwise  transfer  or dispose  of any  Warrants  or  Warrant  Shares for a
specified period of time (not to exceed 90 days) following the effective date of
a  registration  statement  pursuant to which the  Company  proposes to sell its
securities  to the  public  generally;  provided,  however,  that all  executive
officers and directors of the Company enter into similar agreements.

      Section 9. Notices. Any notice,  request, or other communication  required
or permitted hereunder shall be in writing and shall be deemed to have been duly
given  if  delivered  personally,   by  international  courier  service,  or  by
registered mail, airmail postage prepaid, return receipt requested,  to: (a) the
Company at 8505 S.W. Creekside Place,  Beaverton,  Oregon 97008,  U.S.A.,  Attn:
Secretary,  with a copy to Miller, Nash, Wiener, Hager & Carlsen LLP, 3500 U. S.
Bancorp Tower,  111 S.W. Fifth Avenue,  Portland,  Oregon 97204,  U.S.A.,  Attn:
Erich W.  Merrill,  Jr., or at such other  addresses  as may be specified by the
Company by notice given to the Warrantholders in accordance with this Section 9,
and (b) to the  Warrantholders  at the addresses set forth in the registry books
of the Company  referred to in Section  7.1,  with copies to Michel de Beaumont,
American  Equities  Overseas  (U.K.) Ltd.,  16 Old Bond Street,  London W1X 3DB,
United Kingdom, and Jack H. Halperin, Esq., 361 Silver Court, Woodmere, New York
11598, U.S.A. Any notice, request or other communication (other than an Election
to Exercise  Warrants) given by registered airmail shall be deemed given 10 days
after the mailing date; notices,  requests, or other communications given in any
other  manner and any Election to Exercise  Warrants  shall be deemed given when
received.

      Section  10.  Amendment.  This  Warrant  Agreement  may be  amended or its
provisions waived only by an instrument in writing signed by the Company and the
Warrantholder as provided in the Purchase Agreement.

      Section 11. Certain Definitions. Rules 9.02(o) and 9.02(p) of Regulation S
promulgated  under the 1933 Act  defining  "U.S.  person" and  "United  States,"
respectively, are set forth in Appendix 1.

      Section 12. Law Governing. This Warrant Agreement shall be governed by and
construed in  accordance  with the laws of the state of Oregon,  without  giving
effect to choice of laws principles thereof.

      Dated as of ---------------------.

                                EPITOPE, INC.


                                By ---------------------------------------------


                                      - 4 -


<PAGE>



                                   APPENDIX 1

                                       to

                                Warrant Agreement



            Set forth  below is the text of Rule  902(o)  promulgated  under the
1933 Act which defines "U.S. person" as follows:

            (o)  U.S. Person.

            (1)  "U.S. person" means:

            (i)  Any natural person resident in the United States;

            (ii) Any partnership or corporation  organized or incorporated under
      the laws of the United States;

            (iii) Any estate of which any  executor or  administrator  is a U.S.
      person;

            (iv) Any trust of which any trustee is a U.S. person;

            (v) Any agency or branch of a foreign  entity  located in the United
      States;

            (vi) Any nondiscretionary  account or similar account (other than an
      estate or trust)  held by a dealer or other  fiduciary  for the benefit or
      account of a U.S. person;

            (vii) Any  discretionary  account or similar  account (other than an
      estate  or  trust)  held  by  a  dealer  or  other  fiduciary   organized,
      incorporated, or (if an individual) resident in the United States; and

            (viii)  Any   partnership  or  corporation   if:  (A)  organized  or
      incorporated under the laws of any foreign jurisdiction; and (B) formed by
      a U.S.  person  principally for the purpose of investing in securities not
      registered under the 1933 Act, unless it is organized or incorporated, and
      owned,  by  accredited  investors  (as defined in Rule 501(a)) who are not
      natural persons, estates or trusts.

            (2) Notwithstanding paragraph (o)(1) of this rule, any discretionary
account or similar  account (other than an estate or trust) held for the benefit
or  account  of a non-U.S.  person by a dealer or other  professional  fiduciary
organized,  incorporated,  or (if an  individual)  resident in the United States
shall not be deemed a "U.S. person."

            (3)  Notwithstanding  paragraph  (o)(1),  any  estate  of which  any
professional  fiduciary  acting as executor or  administrator  is a U.S.  person
shall not be deemed a U.S. person if:

            (i) An  executor  or  administrator  of the estate who is not a U.S.
      person has sole or shared investment discretion with respect to the assets
      of the estate; and

            (ii)  The estate is governed by foreign law.

            (4)  Notwithstanding  paragraph  (o)(1),  any  trust  of  which  any
professional  fiduciary acting as trustee is a U.S. person shall not be deemed a
U.S. person if a trustee who is not a U.S. person has sole or shared


                                      - i -

<PAGE>



investment  discretion  with respect to the trust assets,  and no beneficiary of
the trust (and no settlor if the trust is revocable) is a U.S. person.

            (5)  Notwithstanding  paragraph  (o)(1),  an employee  benefit  plan
established and  administered in accordance with the law of a country other than
the United States and  customary  practices  and  documentation  of such country
shall not be deemed a U.S. person.

            (6) Notwithstanding paragraph (o)(1), any agency or branch of a U.S.
person located outside the United States shall not be deemed a "U.S. person" if:

            (i)  The agency or branch operates for valid business reasons; and

            (ii) The agency or branch is engaged in the business of insurance or
      banking and is subject to  substantive  insurance  or banking  regulation,
      respectively, in the jurisdiction where located.

            (7) The  International  Monetary  Fund, the  International  Bank for
Reconstruction and Development,  the Inter-American  Development Bank, the Asian
Development Bank, the African  Development  Bank, the United Nations,  and their
agencies,  affiliates  and pension  plans,  and any other similar  international
organizations,  their agencies, affiliates and pension plans shall not be deemed
"U.S. persons."

            Set forth below is the text of Rule  9.02(p)  promulgated  under the
1933 Act which defines "United States" as follows:

            (p)  "United  States"  means  the  United  States  of  America,  its
territories and possessions, any State of the United States, and the District of
Columbia.



                                     - ii -
<PAGE>



                          ELECTION TO EXERCISE WARRANTS

      [NOTE: Unless the transaction has been registered under the 1933 Act or is
      exempt from  registration  thereunder,  this Election to Exercise Warrants
      must be executed, and the Warrant Shares must be delivered, outside of the
      U.S., its territories and possessions.]

To:   Epitope, Inc.
      8505 S.W. Creekside Place
      Beaverton, Oregon  97008
      U.S.A.

      The  undersigned  hereby  exercises  Warrants  represented  by the  within
Warrant  Agreement  for  ________  shares of the Common  Stock of Epitope,  Inc.
("Warrant  Shares"),  and  tenders  payment  herewith  in  the  amount  of  U.S.
$_________ in accordance with the terms thereof.

      The  undersigned  hereby  certifies  that  (mark one of the two  responses
below):

      ___   (i) It is the sole beneficial owner of the Warrants being exercised,
            (ii) it is not a U.S. person, as defined in Appendix 1 to the within
            Warrant Agreement and within the meaning of Regulation S promulgated
            by the U.S.  Securities  and  Exchange  Commission  pursuant  to the
            Securities Act of 1933 ("1933 Act"),  and (iii) it is not exercising
            Warrants for the benefit of any U.S. person.

                                     --OR--

      ___   The  transaction  in which the Warrant Shares will be delivered upon
            exercise of the Warrant has been registered under the 1933 Act or is
            exempt from  registration  thereunder  and Epitope,  Inc.,  has been
            provided  with a written  opinion of  counsel to that  effect or has
            waived the requirement for an opinion. A legal opinion regarding the
            registration of the  transaction  will be obtained at the expense of
            Epitope,  Inc.,  by its  designated  legal  counsel  upon  notice of
            exercise of the Warrant  Agreement by the  Warrantholder at any time
            after the effective  date of a registration  statement  covering the
            transaction;  any other legal opinion shall be the responsibility of
            the Warrantholder.

      THE UNDERSIGNED HEREBY AGREES NOT TO SELL OR OTHERWISE TRANSFER OR DISPOSE
OF THE WARRANT  SHARES FOR A PERIOD ENDING 60 DAYS AFTER THE DATE OF PURCHASE OF
THE WARRANT SHARES.

      Please  deliver  the  certificate  and a new  Warrant  Agreement  for  the
unexercised Warrants, if any, to:

                        ------------------------------------
                        ------------------------------------
                        ------------------------------------
                            Warrantholder:--------------------------------------

                            By--------------------------------------------------
                              Title:

Dated:  --------------, 19--  [Name of  Warrantholder  must be identical to name
                              shown  in  the  registry  books  of  the  Company;
                              signature   must  be   guaranteed  by  a  bank  or
                              brokerage firm doing business in the U.S.]

Warrantholder: -----------------------------------
Address:       -----------------------------------
               -----------------------------------
               -----------------------------------



<PAGE>


                               FORM OF ASSIGNMENT

      [NOTE: Unless the transaction has been registered under the 1933 Act or is
      exempt from registration thereunder, this Assignment must be executed, and
      the  re-issued  Warrants  must be  delivered,  outside  of the  U.S.,  its
      territories and possessions.]



      FOR VALUE  RECEIVED,  the  undersigned  registered  owner of this  Warrant
Agreement hereby sells,  assigns,  and transfers to the Assignee(s)  named below
all of the rights of the undersigned under the Warrant  Agreement,  with respect
to Warrants for the number of shares of Common Stock set forth below:


Name of Assignee                    Address                     No. of Shares*
- ----------------                    -------                     --------------








      *Please note that the minimum denomination in which Warrant Agreements may
be issued is 1,000 shares of Common Stock.



      Dated: ------------, 19--.

                            Warrantholder:--------------------------------------



                                         By-------------------------------------
                                           Title:

                                    [Name of Warrantholder  must be identical to
                                    name  shown  in the  registry  books  of the
                                    Company;  signature  must be guaranteed by a
                                    bank or brokerage firm doing business in the
                                    U.S.]





                        [Form of Notice -- 1993 Warrants]


                            NOTICE TO WARRANTHOLDERS


THE  WARRANTS  REFERRED TO BELOW AND THE SHARES OF COMMON STOCK  UNDERLYING  THE
WARRANTS HAVE NOT BEEN REGISTERED FOR ISSUANCE TO THE  WARRANTHOLDERS  UNDER THE
UNITED STATES  SECURITIES ACT OF 1933, AS AMENDED  ("1933 ACT"),  AND MAY NOT BE
OFFERED,  SOLD,  TRANSFERRED,  PLEDGED, OR OTHERWISE DISPOSED OF, IN WHOLE OR IN
PART, DIRECTLY OR INDIRECTLY, IN THE UNITED STATES OR TO A U. S. PERSON (AS SUCH
TERMS ARE DEFINED IN  REGULATION S UNDER THE 1933 ACT),  NOR MAY THE WARRANTS BE
EXERCISED IN THE UNITED STATES OR BY OR ON BEHALF OF A U. S. PERSON,  UNLESS (i)
THE TRANSACTION IS REGISTERED  UNDER THE 1933 ACT AND ANY APPLICABLE  SECURITIES
LAWS OF ANY STATE,  TERRITORY OR POSSESSION OF THE UNITED STATES OR THE DISTRICT
OF COLUMBIA ("STATE ACT"), OR (ii) AN EXEMPTION FROM REGISTRATION UNDER THE 1933
ACT OR ANY  APPLICABLE  STATE ACT IS  AVAILABLE  AND THE ISSUER HAS  RECEIVED AN
OPINION OF COUNSEL TO SUCH EFFECT REASONABLY SATISFACTORY TO IT.


[Name and Address of Warrantholder]


            Reference is made to the warrants  ("Warrants")  to purchase  common
stock,  no  par  value  ("Common  Stock"),  of  Epitope,  Inc.  (the  "Company")
originally  issued by the  Company on July 23,  1993,  and the  related  Warrant
Agreements ("Warrant Agreements") dated as of the same date containing the terms
of the Warrants.  Capitalized  terms used and not otherwise  defined herein have
the same meanings as in the Warrant Agreements.

            The Expiration  Date for the Warrants,  as previously  extended,  is
September 30, 1997. The Company hereby further extends the Expiration Date until
September 30, 2000.

            The  Company  intends  to  effect  a  spin-off  of  Agritope,   Inc.
("Agritope") by making a dividend  distribution (the "Distribution") of Agritope
common stock to the  Company's  shareholders.  Subject to and effective ten days
after  occurrence of the  Distribution,  the Company will permit exercise of the
Warrants  at a reduced  exercise  price per share  equal to 110  percent  of the
average  closing  price of the Common  Stock on The Nasdaq  Stock Market for the
five consecutive trading days beginning on the date of the Distribution.

            Warrantholders  will  not  receive  Agritope  common  stock  in  the
Distribution  with  respect to shares of Common  Stock  issued upon  exercise of
Warrants after the record date for the Distribution.

            Please attach a copy of this notice to your Warrant Agreement.


Dated:  September 12, 1997.

                       EPITOPE, INC.


                       By ------------------------------------------------------
                          Executive Vice President and Chief Financial Officer


<PAGE>



THESE WARRANTS AND THE SHARES OF COMMON STOCK UNDERLYING THESE WARRANTS HAVE NOT
BEEN  REGISTERED  UNDER THE UNITED  STATES  SECURITIES  ACT OF 1933,  AS AMENDED
("1933 ACT"), AND MAY NOT BE OFFERED, SOLD,  TRANSFERRED,  PLEDGED, OR OTHERWISE
DISPOSED OF, IN WHOLE OR IN PART,  DIRECTLY OR INDIRECTLY,  IN THE UNITED STATES
OR TO A U.S.  PERSON (AS SUCH TERMS ARE DEFINED IN  REGULATION  S UNDER THE 1933
ACT),  NOR MAY THESE  WARRANTS  BE  EXERCISED  IN THE UNITED  STATES OR BY OR ON
BEHALF OF A U.S. PERSON, UNLESS (i) THE TRANSACTION IS REGISTERED UNDER THE 1933
ACT AND ANY APPLICABLE SECURITIES LAWS OF ANY STATE,  TERRITORY OR POSSESSION OF
THE  UNITED  STATES  OR THE  DISTRICT  OF  COLUMBIA  ("STATE  ACT"),  OR (ii) AN
EXEMPTION FROM  REGISTRATION  UNDER THE 1933 ACT OR ANY APPLICABLE  STATE ACT IS
AVAILABLE  AND THE ISSUER  HAS  RECEIVED  AN  OPINION OF COUNSEL TO SUCH  EFFECT
REASONABLY SATISFACTORY TO IT.

COMMON STOCK  PURCHASED  PURSUANT TO THE  EXERCISE OF THESE  WARRANTS MAY NOT BE
SOLD OR OTHERWISE  TRANSFERRED  OR DISPOSED OF FOR A PERIOD OF 60 DAYS AFTER THE
DATE OF PURCHASE OF SUCH COMMON STOCK.


                 VOID AFTER 5 P.M., UNITED STATES PACIFIC TIME,
                              ON SEPTEMBER 30, 2000
                    OR SUCH EARLIER DATE AS SPECIFIED HEREIN

                        WARRANTS TO PURCHASE COMMON STOCK

Warrant No. ___              ______________ Warrants


                                  EPITOPE, INC.

THIS CERTIFIES THAT

                             [name of warrantholder]

or registered assigns, is the registered holder of the number of Warrants (each,
a  "Warrant,"  and  collectively,  "Warrants")  set forth  above.  Each  Warrant
represented by this certificate for Warrants ("Warrant  Agreement") entitles the
registered holder thereof (the "Warrantholder") to purchase from Epitope,  Inc.,
a corporation  incorporated  under the laws of the state of Oregon  ("Company"),
United States of America  ("U.S."),  one fully paid and  nonassessable  share of
common stock, no par value, of the Company  ("Common  Stock") upon  presentation
and  surrender  of this  Warrant  Agreement  with the  accompanying  Election to
Exercise  Warrants duly  completed,  at any time after the Common Stock issuable
upon  exercise of this  Warrant has been  approved  for  quotation on The Nasdaq
Stock Market, and prior to 5 P.M., U.S. Pacific time, on the Expiration Date (as
defined  in Section  2), at the  corporate  offices of the  Company at 8505 S.W.
Creekside  Place,  Beaverton,  Oregon 97008,  or at such other address as may be
specified by the Company  pursuant to Section 9,  accompanied  by payment of the
Exercise Price (as defined herein) and any applicable  taxes,  either in cash in
U.S.  funds or by certified or official bank check in U.S.  funds payable to the
order of the  Company.  These  Warrants  are issued  pursuant to a 1993  Warrant
Purchase  Agreement  ("Purchase  Agreement") among the Company and the Investors
described therein dated as of July 6, 1993.

      Section 1. Exercise  Price.  Each Warrant  entitles the  Warrantholder  to
purchase  one share of Common  Stock for U.S.  $_____  (the  "Exercise  Price"),
subject to adjustment as provided herein.

      Section 2. Expiration. All Warrants not theretofore exercised shall expire
at 5 p.m.,  U.S.  Pacific  time,  on the  earlier  of the  following  dates (the
"Expiration Date"): (a) September 30, 2000, and (b) the expiration of 120



                                      - 1 -

<PAGE>



days after the first period of 20  consecutive  trading days during which period
the average of the high and low sales  prices of the Common  Stock on The Nasdaq
Stock  Market,  or any other  exchange  or national  market  system on which the
Common Stock is then traded, is at least $30.00.

      Section  3.  Adjustments  of  Number  and Kind of Shares  Purchasable  and
Exercise Price. The number and kind of securities or other property  purchasable
upon exercise of a Warrant shall be subject to adjustment from time to time upon
the occurrence, after the date hereof, of the following events:

            3.1 If the  outstanding  shares of the  Company's  Common  Stock are
      divided  into a greater  number of shares or a dividend in Common Stock is
      paid on the Common Stock, the number of shares of Common Stock issuable on
      exercise  of the  Warrants  shall  be  proportionately  increased  and the
      Exercise Price in effect  immediately  prior to such subdivision or at the
      record date of such dividend shall,  simultaneously with the effectiveness
      of such subdivision or immediately after the record date of such dividend,
      be proportionately reduced; and, conversely,  if the outstanding shares of
      Common Stock are combined into a smaller number of shares of Common Stock,
      the  number of  shares  of Common  Stock  issuable  upon  exercise  of the
      Warrants shall be proportionately reduced and the Exercise Price in effect
      immediately  prior  to such  combination  shall,  simultaneously  with the
      effectiveness  of such  combination,  be  proportionately  increased.  The
      increases and reductions provided for in this subsection 3.1 shall be made
      with the intent and, as nearly as practicable, the effect that neither the
      percentage of the total equity of the Company  issuable on exercise of the
      Warrants  nor the price  payable for such  percentage  upon such  exercise
      shall be affected by any event described in this subsection 3.1.

            3.2 No adjustment  of the Exercise  Price will be made if the amount
      of the  adjustment is less than U.S. $.01 per share,  but in that case any
      adjustment  that would  otherwise  be  required to be made will be carried
      forward  and  will be  made at the  time of and  together  with  the  next
      adjustment  of the Exercise  Price  which,  together  with any  adjustment
      carried forward, amounts to U.S. $.01 per share or more.

            3.3 In case of any change in the Common Stock of the Company through
      merger,  consolidation,   reclassification,   reorganization,  partial  or
      complete  liquidation,  or other  change in the capital  structure  of the
      Company  (not  including  a  combination  of  shares  or the  issuance  of
      additional  shares of Common  Stock by the Company by stock split or stock
      dividend),  then, as a condition of the change in the capital structure of
      the  Company,  provision  shall be made so that the holder of this Warrant
      Agreement  will have the right  thereafter to receive upon the exercise of
      the Warrants the kind and amount of shares of stock or other securities or
      property to which such holder  would have been  entitled  if,  immediately
      prior to such  merger,  consolidation,  reclassification,  reorganization,
      recapitalization,  or other change in the capital  structure,  such holder
      had held the number of shares of Common Stock  issuable  upon the exercise
      of the Warrants. In any such case, appropriate adjustment shall be made in
      the  application  of the  provisions  set forth herein with respect to the
      rights and interest  thereafter of the Warrantholder,  to the end that the
      provisions set forth herein shall  thereafter be applicable,  as nearly as
      reasonably  may be, in relation  to any shares of stock or other  property
      thereafter deliverable upon the exercise of the Warrants. The Company will
      not permit any change in its capital  structure to occur unless the issuer
      of the shares of stock or other securities to be received by the holder of
      this  Warrant  Agreement,  if not the  Company,  agrees to be bound by and
      comply with the provisions of this Warrant Agreement.

            3.4 When any  adjustment  is  required  to be made in the  number of
      shares of Common Stock,  other  securities,  or property  purchasable upon
      exercise of the  Warrants,  the Company shall  promptly  determine the new
      number of shares or other securities or property purchasable upon exercise
      of the Warrants and (a) prepare and retain on file a statement  describing
      in  reasonable  detail the method  used in  arriving  at the new number of
      shares or other securities or property



                                      - 2 -

<PAGE>



      purchasable  upon  exercise of the  Warrants  and (b) cause a copy of such
      statement to be mailed to the Warrantholder  within thirty (30) days after
      the date when the event giving rise to the adjustment occurred.

            3.5 No fractional  shares of Common Stock or other  securities shall
      be issued in connection with the exercise of any Warrants, but the Company
      shall pay, in lieu of fractional  shares,  a cash payment  therefor on the
      basis of the closing  price on a national  securities  exchange on the day
      immediately  prior to exercise or, if the Common Stock or other securities
      are not traded on a national securities exchange on such day, on the basis
      of the fair market value  thereof as  determined by the board of directors
      of the Company, which determination shall be conclusive.

            3.6 Notwithstanding  anything herein to the contrary, there shall be
      no  adjustment  made  hereunder on account of the sale and issuance of the
      shares of Common Stock or other  securities  purchasable  upon exercise of
      the Warrants.

      Section  4.  Rights of  Warrantholder  as  Shareholder.  No holder of this
Warrant Agreement shall, as such, be entitled to vote, receive dividends,  or be
deemed the holder of Common  Stock or any other  securities  of the Company that
may at any time be issuable on the exercise hereof for any purpose whatever, nor
shall anything  contained  herein be construed to confer upon the holder of this
Warrant Agreement, as such, any of the rights of a shareholder of the Company or
any right to vote for the election of directors or upon any matter  submitted to
shareholders at any meeting thereof or give or withhold consent to any corporate
action (whether upon any matter submitted to shareholders at any meeting thereof
or otherwise)  including,  without limitation,  giving or withholding consent to
any  merger,  recapitalization,  issuance of stock,  reclassification  of stock,
exchange of stock, change of stock to par value, consolidation or conveyance, or
to receive  notice of meetings or other  actions  affecting  shareholders  or to
receive dividends or subscription rights or other distributions.

      Section 5. Payment of Certain Taxes and Charges.  The Company shall not be
required to issue or deliver any certificate for shares of Common Stock or other
securities upon the exercise of Warrants  evidenced by this Warrant Agreement or
to register the transfer of the Warrants  evidenced  hereby until any applicable
transfer tax and any other taxes or governmental charges that the Company may be
required by law to collect in respect of such  exercise  or transfer  shall have
been paid, such tax being payable by the holder of this Warrant Agreement at the
time of surrender for exercise or transfer.

      Section 6. Registration. The Company has prepared a registration statement
on Form S-3 (the  "Registration  Statement")  under the 1933 Act with respect to
the  resale  by the  Warrantholder  of the  Warrants  covered  by  this  Warrant
Agreement  and of the shares of Common Stock issued or issuable upon exercise of
this Warrant Agreement (the "Warrant Shares").  As soon as practicable after the
original issue date of this Warrant  Agreement (the "Original Issue Date"),  the
Company  shall file the  Registration  Statement  with the U.S.  Securities  and
Exchange  Commission  and shall use its best  efforts to cause the  Registration
Statement  to become  effective  under the 1933 Act as promptly  as  practicable
after the Original  Issue Date as provided for in, and in accordance  with,  the
terms and conditions of the Purchase Agreement.

      Section 7.  Transfer and Exchange.

            7.1 Transfer. This Warrant Agreement is transferable on the registry
      books of the Company subject to the  restrictions on the first page hereof
      and in Section 7.4. The Company may deem and treat the person or entity in
      whose name this Warrant  Agreement  is  registered  as the absolute  owner
      hereof (notwithstanding any notation of ownership or other writing thereon
      made by anyone other than the Company) for all purposes whatever,  and the
      Company shall not be affected by any notice to the contrary.

            7.2  Exchange.  Subject to the  provisions  of  Section  7.4 and the
      restrictions  on  the  first  page  hereof,   this  Warrant  Agreement  is
      exchangeable at the principal office of the Company



                                      - 3 -

<PAGE>



      for Warrant  Agreements to purchase the same aggregate number of shares of
      Common Stock as are purchasable  hereunder,  each new Warrant Agreement to
      represent the right to purchase such number of shares as the Warrantholder
      shall designate at the time of such exchange.

            7.3 Securities Act of 1933. The Warrantholder, by acceptance hereof,
      agrees that this Warrant  Agreement  and the shares of Common Stock issued
      or issuable upon exercise of this Warrant  Agreement may not be offered or
      sold except in compliance with the 1933 Act. The Warrantholder consents to
      the Company's making a notation on its records and on the certificates for
      any  shares  of  Common  Stock  issued  upon  exercise  hereof in order to
      implement such restriction on transferability.

            7.4 Minimum Warrant Agreement Amount. Notwithstanding the provisions
      of Section 7.1 and Section 7.2, the Company shall not be required to issue
      a Warrant Agreement for Warrants covering less than 1,000 shares of Common
      Stock,  except in the case of a partial  exercise by the  Warrantholder of
      this Warrant  Agreement that leaves Warrants  exercisable to purchase less
      than  1,000  shares  that  are to  remain  registered  in the  name of the
      exercising Warrantholder,  and any subsequent partial exercise,  transfer,
      or exchange of such Warrant Agreement.

            7.5 No Transfer of Common Stock for 60 Days.  Common Stock purchased
      pursuant to the  exercise of these  Warrants  may not be sold or otherwise
      transferred  or  disposed  of for a period  of 60 days  after  the date of
      purchase of such Common Stock.

      Section 8.  Holdback  Agreement.  The  Warrantholder,  if requested by the
Company and an underwriter of the Company's securities,  shall agree not to sell
or  otherwise  transfer  or dispose  of any  Warrants  or  Warrant  Shares for a
specified period of time (not to exceed 90 days) following the effective date of
a  registration  statement  pursuant to which the  Company  proposes to sell its
securities  to the  public  generally;  provided,  however,  that all  executive
officers and directors of the Company enter into similar agreements.

      Section 9. Notices. Any notice,  request, or other communication  required
or permitted hereunder shall be in writing and shall be deemed to have been duly
given  if  delivered  personally,   by  international  courier  service,  or  by
registered mail, airmail postage prepaid, return receipt requested,  to: (a) the
Company at 8505 S.W. Creekside Place,  Beaverton,  Oregon 97008,  U.S.A.,  Attn:
Secretary,  with a copy to Miller, Nash, Wiener, Hager & Carlsen LLP, 3500 U. S.
Bancorp Tower,  111 S.W. Fifth Avenue,  Portland,  Oregon 97204,  U.S.A.,  Attn:
Erich W.  Merrill,  Jr., or at such other  addresses  as may be specified by the
Company by notice given to the Warrantholders in accordance with this Section 9,
and (b) to the  Warrantholders  at the addresses set forth in the registry books
of the Company  referred to in Section  7.1,  with copies to Michel de Beaumont,
American  Equities  Overseas  (U.K.) Ltd.,  16 Old Bond Street,  London W1X 3DB,
United Kingdom, and Jack H. Halperin, Esq., 361 Silver Court, Woodmere, New York
11598, U.S.A. Any notice, request or other communication (other than an Election
to Exercise Warrants) given by registered airmail shall be deemed given ten days
after the mailing date; notices,  requests, or other communications given in any
other  manner and any Election to Exercise  Warrants  shall be deemed given when
received.

      Section  10.  Amendment.  This  Warrant  Agreement  may be  amended or its
provisions waived only by an instrument in writing signed by the Company and the
Warrantholder as provided in the Purchase Agreement.

      Section 11. Certain Definitions. Rules 9.02(o) and 9.02(p) of Regulation S
promulgated  under the 1933 Act  defining  "U.S.  person" and  "United  States,"
respectively, are set forth in Appendix 1.




                                      - 4 -

<PAGE>



      Section 12. Law Governing. This Warrant Agreement shall be governed by and
construed in  accordance  with the laws of the state of Oregon,  without  giving
effect to choice of laws principles thereof.

      Dated as of --------------.

                                    EPITOPE, INC.


                                    By -----------------------------------------



                                      - 5 -

<PAGE>



                                   APPENDIX 1

                                       to

                                Warrant Agreement



            Set forth  below is the text of Rule  902(o)  promulgated  under the
1933 Act which defines "U.S. person" as follows:

            (o)  U.S. Person.

            (1)  "U.S. person" means:

            (i)  Any natural person resident in the United States;

            (ii) Any partnership or corporation  organized or incorporated under
      the laws of the United States;

            (iii) Any estate of which any  executor or  administrator  is a U.S.
      person;

            (iv)  Any trust of which any trustee is a U.S. person;

            (v) Any agency or branch of a foreign  entity  located in the United
      States;

            (vi) Any nondiscretionary  account or similar account (other than an
      estate or trust)  held by a dealer or other  fiduciary  for the benefit or
      account of a U.S. person;

            (vii) Any  discretionary  account or similar  account (other than an
      estate  or  trust)  held  by  a  dealer  or  other  fiduciary   organized,
      incorporated, or (if an individual) resident in the United States; and

            (viii)  Any   partnership  or  corporation   if:  (A)  organized  or
      incorporated under the laws of any foreign jurisdiction; and (B) formed by
      a U.S.  person  principally for the purpose of investing in securities not
      registered under the 1933 Act, unless it is organized or incorporated, and
      owned,  by  accredited  investors  (as defined in Rule 501(a)) who are not
      natural persons, estates or trusts.

            (2) Notwithstanding paragraph (o)(1) of this rule, any discretionary
account or similar  account (other than an estate or trust) held for the benefit
or  account  of a non-U.S.  person by a dealer or other  professional  fiduciary
organized,  incorporated,  or (if an  individual)  resident in the United States
shall not be deemed a "U.S. person."

            (3)  Notwithstanding  paragraph  (o)(1),  any  estate  of which  any
professional  fiduciary  acting as executor or  administrator  is a U.S.  person
shall not be deemed a U.S. person if:

            (i) An  executor  or  administrator  of the estate who is not a U.S.
      person has sole or shared investment discretion with respect to the assets
      of the estate; and

            (ii)  The estate is governed by foreign law.




                                      - i -

<PAGE>



            (4)  Notwithstanding  paragraph  (o)(1),  any  trust  of  which  any
professional  fiduciary acting as trustee is a U.S. person shall not be deemed a
U.S. person if a trustee who is not a U.S. person has sole or shared  investment
discretion  with respect to the trust assets,  and no  beneficiary  of the trust
(and no settlor if the trust is revocable) is a U.S. person.

            (5)  Notwithstanding  paragraph  (o)(1),  an employee  benefit  plan
established and  administered in accordance with the law of a country other than
the United States and  customary  practices  and  documentation  of such country
shall not be deemed a U.S. person.

            (6) Notwithstanding paragraph (o)(1), any agency or branch of a U.S.
person located outside the United States shall not be deemed a "U.S. person" if:

            (i)  The agency or branch operates for valid business reasons; and

            (ii) The agency or branch is engaged in the business of insurance or
      banking and is subject to  substantive  insurance  or banking  regulation,
      respectively, in the jurisdiction where located.

            (7) The  International  Monetary  Fund, the  International  Bank for
Reconstruction and Development,  the Inter-American  Development Bank, the Asian
Development Bank, the African  Development  Bank, the United Nations,  and their
agencies,  affiliates  and pension  plans,  and any other similar  international
organizations,  their agencies, affiliates and pension plans shall not be deemed
"U.S. persons."

            Set forth below is the text of Rule  9.02(p)  promulgated  under the
1933 Act which defines "United States" as follows:

            (p)  "United  States"  means  the  United  States  of  America,  its
territories and possessions, any State of the United States, and the District of
Columbia.



<PAGE>



                          ELECTION TO EXERCISE WARRANTS

      [NOTE: Unless the transaction has been registered under the 1933 Act or is
      exempt from  registration  thereunder,  this Election to Exercise Warrants
      must be executed, and the Warrant Shares must be delivered, outside of the
      U.S., its territories and possessions.]

To:   Epitope, Inc.
      8505 S.W. Creekside Place
      Beaverton, Oregon  97008
      U.S.A.

      The  undersigned  hereby  exercises  Warrants  represented  by the  within
Warrant  Agreement  for  ________  shares of the Common  Stock of Epitope,  Inc.
("Warrant  Shares"),  and  tenders  payment  herewith  in  the  amount  of  U.S.
$_________ in accordance with the terms thereof.

      The  undersigned  hereby  certifies  that  (mark one of the two  responses
below):

      ___   (i) It is the sole beneficial owner of the Warrants being exercised,
            (ii) it is not a U.S. person, as defined in Appendix 1 to the within
            Warrant Agreement and within the meaning of Regulation S promulgated
            by the U.S.  Securities  and  Exchange  Commission  pursuant  to the
            Securities Act of 1933 ("1933 Act"),  and (iii) it is not exercising
            Warrants for the benefit of any U.S. person.

                                     --OR--

      ___   The  transaction  in which the Warrant Shares will be delivered upon
            exercise of the Warrant has been registered under the 1933 Act or is
            exempt from  registration  thereunder  and Epitope,  Inc.,  has been
            provided  with a written  opinion of  counsel to that  effect or has
            waived the requirement for an opinion. A legal opinion regarding the
            registration of the  transaction  will be obtained at the expense of
            Epitope,  Inc.,  by its  designated  legal  counsel  upon  notice of
            exercise of the Warrant  Agreement by the  Warrantholder at any time
            after the effective  date of a registration  statement  covering the
            transaction;  any other legal opinion shall be the responsibility of
            the Warrantholder.

      THE UNDERSIGNED HEREBY AGREES NOT TO SELL OR OTHERWISE TRANSFER OR DISPOSE
OF THE WARRANT  SHARES FOR A PERIOD ENDING 60 DAYS AFTER THE DATE OF PURCHASE OF
THE WARRANT SHARES.

      Please  deliver  the  certificate  and a new  Warrant  Agreement  for  the
unexercised Warrants, if any, to:

                        ------------------------------------
                        ------------------------------------
                        ------------------------------------

                    Warrantholder:----------------------------------------------


                    By----------------------------------------------------------
                      Title:


Dated: ----------------, 199-

                    [Name of  Warrantholder  must be  identical to name shown in
                    the  registry  books  of  the  Company;  signature  must  be
                    guaranteed by a bank or brokerage firm doing business in the
                    U.S.]

Warrantholder: -------------------------------------
Address:       -------------------------------------
               -------------------------------------
               -------------------------------------


<PAGE>


                               FORM OF ASSIGNMENT

      [NOTE: Unless the transaction has been registered under the 1933 Act or is
      exempt from registration thereunder, this Assignment must be executed, and
      the  re-issued  Warrants  must be  delivered,  outside  of the  U.S.,  its
      territories and possessions.]



      FOR VALUE  RECEIVED,  the  undersigned  registered  owner of this  Warrant
Agreement hereby sells,  assigns,  and transfers to the Assignee(s)  named below
all of the rights of the undersigned under the Warrant  Agreement,  with respect
to Warrants for the number of shares of Common Stock set forth below:


Name of Assignee              Address                           No. of Shares*
- ----------------              -------                           --------------








      *Please note that the minimum denomination in which Warrant Agreements may
be issued is 1,000 shares of Common Stock.



      Dated: ------------, 19---.

                            Warrantholder:--------------------------------------



                                           By-----------------------------------
                                             Title:

                            [Name of  Warrantholder  must be  identical  to name
                            shown  in  the   registry   books  of  the  Company;
                            signature  must be guaranteed by a bank or brokerage
                            firm doing business in the U.S.]




                                     - iv -


               [Form of Notice -- Technology Transfer Warrants]

                           NOTICE TO WARRANTHOLDERS


THE  WARRANTS  REFERRED TO BELOW AND THE SHARES OF COMMON STOCK  UNDERLYING  THE
WARRANTS HAVE NOT BEEN REGISTERED FOR ISSUANCE TO THE  WARRANTHOLDERS  UNDER THE
SECURITIES ACT OF 1933, AS AMENDED ("1933 ACT"),  AND MAY NOT BE OFFERED,  SOLD,
PLEDGED,  OR OTHERWISE  TRANSFERRED AND THE WARRANTS MAY NOT BE EXERCISED UNLESS
THE TRANSACTION IS REGISTERED UNDER THE 1933 ACT AND APPLICABLE STATE SECURITIES
LAWS OR UNLESS AN EXEMPTION  FROM  REGISTRATION  IS AVAILABLE  AND THE ISSUER IS
FURNISHED  A  SATISFACTORY  OPINION OF  COUNSEL  THAT SUCH  REGISTRATION  IS NOT
REQUIRED.


[Name and Address of Warrantholder]


            Reference is made to the warrants  ("Warrants")  to purchase  common
stock,  no  par  value  ("Common  Stock"),  of  Epitope,  Inc.  (the  "Company")
originally  issued by the  Company on August 1, 1993,  and the  related  Warrant
Agreements ("Warrant Agreements") dated as of the same date containing the terms
of the Warrants.  Capitalized  terms used and not otherwise  defined herein have
the same meanings as in the Warrant Agreements.

            The Expiration  Date for the Warrants,  as previously  extended,  is
September 30, 1997. The Company hereby further extends the Expiration Date until
September 30, 2000.

            The  Company  intends  to  effect  a  spin-off  of  Agritope,   Inc.
("Agritope") by making a dividend  distribution (the "Distribution") of Agritope
common stock to the  Company's  shareholders.  Subject to and effective ten days
after  occurrence of the  Distribution,  the Company will permit exercise of the
Warrants  at a reduced  exercise  price per share  equal to 110  percent  of the
average  closing  price of the Common  Stock on The Nasdaq  Stock Market for the
five  consecutive  trading days beginning on the date of the  Distribution.  The
Company waives payment of the additional Cash Purchase Consideration  referenced
in the Warrant Agreements.

            Warrantholders  will  not  receive  Agritope  common  stock  in  the
Distribution  with  respect to shares of Common  Stock  issued upon  exercise of
Warrants after the record date for the Distribution.

            Please attach a copy of this notice to your Warrant Agreement.

Dated:  September 12, 1997.

                    EPITOPE, INC.



                    By-------------------------------------------------------
                         Executive Vice President and Chief Financial Officer





<PAGE>



THESE WARRANTS AND THE SHARES OF COMMON STOCK UNDERLYING THESE WARRANTS HAVE NOT
BEEN REGISTERED  UNDER THE SECURITIES ACT OF 1933, AS AMENDED ("1933 ACT"),  AND
MAY NOT BE OFFERED,  SOLD,  PLEDGED,  OR OTHERWISE  TRANSFERRED  UNLESS THEY ARE
REGISTERED  UNDER THE 1933 ACT AND APPLICABLE STATE SECURITIES LAWS OR UNLESS AN
EXEMPTION  FROM  REGISTRATION  IS  AVAILABLE  AND  THE  ISSUER  IS  FURNISHED  A
SATISFACTORY OPINION OF COUNSEL THAT SUCH REGISTRATION IS NOT REQUIRED.

COMMON STOCK  PURCHASED  PURSUANT TO THE  EXERCISE OF THESE  WARRANTS MAY NOT BE
SOLD OR OTHERWISE  TRANSFERRED  OR DISPOSED OF FOR A PERIOD OF 60 DAYS AFTER THE
DATE OF PURCHASE OF SUCH COMMON STOCK.


                 VOID AFTER 5 P.M., UNITED STATES PACIFIC TIME,
                              ON SEPTEMBER 30, 2000
                    OR SUCH EARLIER DATE AS SPECIFIED HEREIN

                        WARRANTS TO PURCHASE COMMON STOCK

Warrant No. _______________
                            _______________ Warrants


                                 EPITOPE, INC.

                              THIS CERTIFIES THAT

                            [Name of Warrantholder]

or registered  assigns is the registered holder of the number of Warrants (each,
a  "Warrant,"  and  collectively,  "Warrants")  set forth  above.  Each  Warrant
represented by this certificate for Warrants ("Warrant  Agreement") entitles the
registered holder thereof (the "Warrantholder") to purchase from Epitope,  Inc.,
a corporation  incorporated  under the laws of the state of Oregon  ("Company"),
United States of America  ("U.S."),  one fully paid and  nonassessable  share of
common stock, no par value, of the Company  ("Common  Stock") upon  presentation
and  surrender  of this  Warrant  Agreement  with the  accompanying  Election to
Exercise  Warrants duly  completed,  at any time prior to 5 P.M.,  U.S.  Pacific
time, on the Expiration Date (as defined in Section 2), at the corporate offices
of the Company at 8505 S.W. Creekside Place, Beaverton, Oregon 97008, or at such
other  address  as may be  specified  by  the  Company  pursuant  to  Section  ,
accompanied  by  payment  of the  Exercise  Price (as  defined  herein)  and any
applicable taxes,  either in cash in U.S. funds or by certified or official bank
check in U.S.  funds  payable to the order of the  Company.  These  Warrants are
issued  pursuant  to a  1993  Technology  Transfer  Warrant  Issuance  Agreement
("Issuance  Agreement")  among the Company and the Investors  described  therein
dated as of June 15, 1993.

   Section 1.  Exercise  Price.  Each  Warrant  entitles  the  Warrantholder  to
purchase  one share of Common  Stock for U.S.  $_____  (the  "Exercise  Price"),
subject to adjustment as provided herein.

   Section 2. Expiration. All Warrants not theretofore exercised shall expire at
5  p.m.,  U.S.  Pacific  time,  on the  earlier  of  the  following  dates  (the
"Expiration  Date"):  (a) September 30, 2000, and (b) the expiration of 120 days
after the first  period of 20  consecutive  trading days during which period the
average of the high and low sales prices of the Common Stock on The Nasdaq Stock
Market,  or any other  exchange  or national  market  system on which the Common
Stock is then traded, is at least $30.00.




                                      - 1 -

<PAGE>



   Section 3. Adjustments of Number and Kind of Shares  Purchasable and Exercise
Price.  The number and kind of securities  or other  property  purchasable  upon
exercise of a Warrant shall be subject to adjustment  from time to time upon the
occurrence, after the date hereof, of the following events:

        3.1 If the outstanding  shares of the Company's Common Stock are divided
   into a greater  number of shares or a dividend in Common Stock is paid on the
   Common  Stock,  the number of shares of Common Stock  issuable on exercise of
   the Warrants  shall be  proportionately  increased and the Exercise  Price in
   effect  immediately  prior to such  subdivision or at the record date of such
   dividend shall,  simultaneously with the effectiveness of such subdivision or
   immediately  after  the  record  date of such  dividend,  be  proportionately
   reduced;  and,  conversely,  if the  outstanding  shares of Common  Stock are
   combined  into a smaller  number of shares  of Common  Stock,  the  number of
   shares of Common  Stock  issuable  upon  exercise  of the  Warrants  shall be
   proportionately reduced and the Exercise Price in effect immediately prior to
   such  combination  shall,  simultaneously  with  the  effectiveness  of  such
   combination,  be  proportionately  increased.  The increases  and  reductions
   provided  for in this  subsection  3.1 shall be made with the intent  and, as
   nearly as  practicable,  the effect that neither the  percentage of the total
   equity of the Company  issuable on  exercise  of the  Warrants  nor the price
   payable for such percentage upon such exercise shall be affected by any event
   described in this subsection 3.1.

        3.2 No  adjustment  of the Exercise  Price will be made if the amount of
   the  adjustment  is less  than  U.S.  $.01 per  share,  but in that  case any
   adjustment  that  would  otherwise  be  required  to be made will be  carried
   forward and will be made at the time of and together with the next adjustment
   of the Exercise Price which,  together with any adjustment  carried  forward,
   amounts to U.S. $.01 per share or more.

        3.3 In case of any change in the  Common  Stock of the  Company  through
   merger, consolidation, reclassification,  reorganization, partial or complete
   liquidation,  or other  change in the capital  structure  of the Company (not
   including a  combination  of shares or the issuance of  additional  shares of
   Common  Stock by the Company by stock split or stock  dividend),  then,  as a
   condition of the change in the capital  structure  of the Company,  provision
   shall be made so that the  holder  of this  Warrant  Agreement  will have the
   right  thereafter  to receive  upon the exercise of the Warrants the kind and
   amount of shares  of stock or other  securities  or  property  to which  such
   holder  would  have  been  entitled  if,  immediately  prior to such  merger,
   consolidation, reclassification,  reorganization,  recapitalization, or other
   change in the capital structure, such holder had held the number of shares of
   Common Stock  issuable upon the exercise of the  Warrants.  In any such case,
   appropriate adjustment shall be made in the application of the provisions set
   forth  herein  with  respect  to the rights and  interest  thereafter  of the
   Warrantholder,  to the  end  that  the  provisions  set  forth  herein  shall
   thereafter be applicable,  as nearly as reasonably may be, in relation to any
   shares of stock or other property thereafter deliverable upon the exercise of
   the Warrants. The Company will not permit any change in its capital structure
   to occur unless the issuer of the shares of stock or other  securities  to be
   received by the holder of this Warrant Agreement,  if not the Company, agrees
   to be bound by and comply with the provisions of this Warrant Agreement.

        3.4 When any  adjustment  is required to be made in the number of shares
   of Common Stock, other securities,  or property  purchasable upon exercise of
   the Warrants,  the Company shall promptly  determine the new number of shares
   or other securities or property purchasable upon exercise of the Warrants and
   (a) prepare and retain on file a statement  describing in  reasonable  detail
   the method used in  arriving at the new number of shares or other  securities
   or property purchasable upon exercise of the Warrants and (b) cause a copy of
   such  statement  to be mailed to the  Warrantholder  within  thirty (30) days
   after the date when the event giving rise to the adjustment occurred.

        3.5 No fractional  shares of Common Stock or other  securities  shall be
   issued in connection with the exercise of any Warrants, but the Company shall
   pay, in lieu of fractional  shares,  a cash payment  therefor on the basis of
   the closing price on a national  securities  exchange on the day  immediately
   prior to exercise or, if the Common Stock or other  securities are not traded
   on a national securities exchange



                                      - 2 -

<PAGE>



   on such day, on the basis of the fair market value  thereof as  determined by
   the  board  of  directors  of  the  Company,  which  determination  shall  be
   conclusive.

        3.6 Notwithstanding  anything herein to the contrary,  there shall be no
   adjustment  made  hereunder on account of the sale and issuance of the shares
   of  Common  Stock  or  other  securities  purchasable  upon  exercise  of the
   Warrants.

   Section 4. Rights of Warrantholder as Shareholder.  No holder of this Warrant
Agreement shall, as such, be entitled to vote, receive  dividends,  or be deemed
the holder of Common  Stock or any other  securities  of the Company that may at
any time be issuable on the exercise hereof for any purpose whatever,  nor shall
anything contained herein be construed to confer upon the holder of this Warrant
Agreement,  as such,  any of the rights of a  shareholder  of the Company or any
right to vote for the  election of  directors  or upon any matter  submitted  to
shareholders at any meeting thereof or give or withhold consent to any corporate
action (whether upon any matter submitted to shareholders at any meeting thereof
or otherwise)  including,  without limitation,  giving or withholding consent to
any  merger,  recapitalization,  issuance of stock,  reclassification  of stock,
exchange of stock, change of stock to par value, consolidation or conveyance, or
to receive  notice of meetings or other  actions  affecting  shareholders  or to
receive dividends or subscription rights or other distributions.

   Section 5.  Payment of Certain  Taxes and Charges.  The Company  shall not be
required to issue or deliver any certificate for shares of Common Stock or other
securities upon the exercise of Warrants  evidenced by this Warrant Agreement or
to register the transfer of the Warrants  evidenced  hereby until any applicable
transfer tax and any other taxes or governmental charges that the Company may be
required by law to collect in respect of such  exercise  or transfer  shall have
been paid, such tax being payable by the holder of this Warrant Agreement at the
time of surrender for exercise or transfer.

   Section 6. Registration. The Company has prepared a registration statement on
Form S-3 (the  "Registration  Statement") under the 1933 Act with respect to the
resale by the  Warrantholder  of the shares of Common  Stock  issued or issuable
upon  exercise of this Warrant  Agreement  (the  "Warrant  Shares").  As soon as
practicable  after  the  original  issue  date of this  Warrant  Agreement  (the
"Original Issue Date"),  the Company shall file the Registration  Statement with
the U.S.  Securities  and Exchange  Commission and shall use its best efforts to
cause  the  Registration  Statement  to become  effective  under the 1933 Act as
promptly as practicable after the Original Issue Date as provided for in, and in
accordance with, the terms and conditions of the Issuance Agreement.

   Section 7.  Transfer and Exchange.

        7.1 Transfer.  This Warrant  Agreement is  transferable  on the registry
   books of the Company subject to the restrictions on the first page hereof and
   in Section  7.4. The Company may deem and treat the person or entity in whose
   name this  Warrant  Agreement  is  registered  as the  absolute  owner hereof
   (notwithstanding  any notation of ownership or other writing  thereon made by
   anyone other than the Company)  for all  purposes  whatever,  and the Company
   shall not be affected by any notice to the contrary.

        7.2 Exchange.  Subject to the provisions of Section and the restrictions
   on the first page hereof,  this  Warrant  Agreement  is  exchangeable  at the
   principal  office of the Company for Warrant  Agreements to purchase the same
   aggregate number of shares of Common Stock as are purchasable hereunder, each
   new Warrant  Agreement  to  represent  the right to  purchase  such number of
   shares as the Warrantholder shall designate at the time of such exchange.

        7.3  Securities Act of 1933. The  Warrantholder,  by acceptance  hereof,
   agrees that this Warrant  Agreement  and the shares of Common Stock issued or
   issuable upon  exercise of this Warrant  Agreement may not be offered or sold
   except in  compliance  with the 1933 Act. The  Warrantholder  consents to the
   Company's  making a notation on its records and on the  certificates  for any
   shares of Common Stock issued upon exercise hereof in order to implement such
   restriction on transferability.




                                      - 3 -
<PAGE>



        7.4 Minimum Warrant Agreement Amount.  Notwithstanding the provisions of
   Section  7.1 and  Section  , the  Company  shall not be  required  to issue a
   Warrant  Agreement  for  Warrants  covering  less than 1,000 shares of Common
   Stock,  except in the case of a partial exercise by the Warrantholder of this
   Warrant  Agreement  that leaves  Warrants  exercisable  to purchase less than
   1,000  shares  that are to remain  registered  in the name of the  exercising
   Warrantholder,  and any subsequent partial exercise, transfer, or exchange of
   such Warrant Agreement.

        7.5 No  Transfer of Common  Stock for 60 Days.  Common  Stock  purchased
   pursuant  to the  exercise  of these  Warrants  may not be sold or  otherwise
   transferred or disposed of for a period of 60 days after the date of purchase
   of such Common Stock.

   Section 8. Holdback Agreement. The Warrantholder, if requested by the Company
and an  underwriter  of the  Company's  securities,  shall  agree not to sell or
otherwise  transfer or dispose of any Warrants or Warrant Shares for a specified
period  of time  (not to  exceed  90 days)  following  the  effective  date of a
registration  statement  pursuant  to which  the  Company  proposes  to sell its
securities  to the  public  generally;  provided,  however,  that all  executive
officers and directors of the Company enter into similar agreements.

   Section 9. Notices. Any notice,  request, or other communication  required or
permitted  hereunder  shall be in writing  and shall be deemed to have been duly
given if delivered  personally or by certified  mail,  postage  prepaid,  return
receipt requested,  to: (a) the Company at 8505 S.W. Creekside Place, Beaverton,
Oregon 97008, Attn:  Secretary,  with a copy to Miller,  Nash,  Wiener,  Hager &
Carlsen,  3500 U.S.  Bancorp  Tower,  111 S.W.  Fifth Avenue,  Portland,  Oregon
97204-3699,  Attn: Erich W. Merrill,  Jr. and (b) to the  Warrantholders  at the
addresses set forth in the registry books of the Company  referred to in Section
7.1. Any notice,  request,  or other communication given by certified mail shall
be deemed  given 10 days after the mailing  date;  notices,  requests,  or other
communications given in any other manner shall be deemed given when received.

   Section  10.  Amendment.  This  Warrant  Agreement  may  be  amended  or  its
provisions waived only by an instrument in writing signed by the Company and the
Warrantholder as provided in the Issuance Agreement.

   Section 11. Law Governing.  This Warrant  Agreement  shall be governed by and
construed in  accordance  with the laws of the state of Oregon,  without  giving
effect to choice of laws principles thereof.

   Dated as of _______________.

                                      EPITOPE, INC.


                                      By----------------------------------------







                                      - 4 -


<PAGE>



                          ELECTION TO EXERCISE WARRANT


To: Epitope, Inc.
    8505 S.W. Creekside Place
    Beaverton, Oregon  97008

        The  undersigned  hereby  exercises  the within  Warrant  Agreement  for
________ shares of the Common Stock of Epitope,  Inc.  ("Warrant  Shares"),  and
tenders payment herewith in the amount of U.S. $_________ in accordance with the
terms thereof.

THE WARRANTS MAY NOT BE EXERCISED UNLESS THE TRANSACTION IS REGISTERED UNDER THE
1933 ACT AND  APPLICABLE  STATE  SECURITIES  LAWS OR  UNLESS AN  EXEMPTION  FROM
REGISTRATION IS AVAILABLE AND THE ISSUER IS FURNISHED A SATISFACTORY  OPINION OF
COUNSEL THAT SUCH REGISTRATION IS NOT REQUIRED.

THE  UNDERSIGNED  HEREBY AGREES NOT TO SELL OR OTHERWISE  TRANSFER OR DISPOSE OF
THE WARRANT SHARES FOR A PERIOD ENDING 60 DAYS AFTER THE DATE OF PURCHASE OF THE
WARRANT SHARES.

   Please  deliver  the  certificate  and  a  new  Warrant   Agreement  for  the
unexercised Warrants, if any, to:

                  ------------------------------------
                  ------------------------------------
                  ------------------------------------


                            Warrantholder:--------------------------------------


                            By--------------------------------------------------
                               Title:

                            [Name of  Warrantholder  must be  identical  to name
                            shown  in  the   registry   books  of  the  Company;
                            signature  must be guaranteed by a bank or brokerage
                            firm doing business in the United States.]

Dated:  -------------, 199--.

Warrantholder:   -------------------------------------
Address:   -------------------------------------------
           -------------------------------------------
           -------------------------------------------



<PAGE>


                              FORM OF ASSIGNMENT


        FOR VALUE  RECEIVED,  the undersigned  registered  owner of this Warrant
Agreement hereby sells,  assigns,  and transfers to the Assignee(s)  named below
all of the rights of the undersigned under the Warrant  Agreement,  with respect
to Warrants for the number of shares of Common Stock set forth below:


Name of Assignee            Address                             No. of Shares*
- ----------------            -------                             --------------







   *Please note that the minimum denomination in which Warrant Agreements may be
issued is 1,000 shares of Common Stock.

        The  undersigned  agrees  to  furnish  to the  Company  upon  request  a
satisfactory  opinion of counsel to the effect that the transfer requested above
is exempt from the  Securities  Act of 1933, as amended,  and  applicable  state
securities laws.

   Dated: --------------, 19---.

                            Warrantholder:  ------------------------------------



                            By--------------------------------------------------
                              Title:


                            [Name of  Warrantholder  must be  identical  to name
                            shown  in  the   registry   books  of  the  Company;
                            signature  must be guaranteed by a bank or brokerage
                            firm doing business in the United States.]




                                      - 6 -





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