EPITOPE INC/OR/
S-4/A, 1997-03-17
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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<PAGE>



                                                     Registration No. 333-15705


                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549




                                 Amendment No. 5

                                       to
                                    FORM S-4
                          REGISTRATION STATEMENT UNDER
                           THE SECURITIES ACT OF 1933



                                  EPITOPE, INC.
             (Exact name of registrant as specified in its charter)

        Oregon                         3841                     93-0779127
(State of incorporation)  (Primary Standard Industrial        (IRS employer
                            Classification Code Number       identification
                                                                 number)

               8505 S.W. Creekside Place, Beaverton, Oregon 97008
                                 (503) 641-6115
               (Address, including zip code, and telephone number,
                 including area code, of registrant's principal
                               executive offices)

          Adolph J. Ferro, Ph.D., PRESIDENT AND CHIEF EXECUTIVE OFFICER
                                  Epitope, Inc.
               8505 S.W. Creekside Place, Beaverton, Oregon 97008
                                 (503) 641-6115
   (Name and address, including zip code, and telephone number, including area
                           code, of agent for service)

                                   Copies to:
Erich W. Merrill, Jr.                        Charles W. Mulaney, Jr.
Miller, Nash, Wiener, Hager & Carlsen LLP    Rodd M. Schreiber
111 S.W. Fifth Avenue                        Skadden, Arps, Slate,
Portland, Oregon 97204-3699                  Meagher & Flom (Illinois)
(503) 224-5858                               333 W. Wacker Drive
                                             Chicago, Illinois 60606
                                             (312) 407-0700

Approximate  date of  commencement  of proposed  sale to the public:  As soon as
possible after approval by shareholders.

If the securities  being registered on this form are being offered in connection
with the  formation of a holding  company and there is  compliance  with General
Instruction G, check the following box. [ ]


The Registrant hereby amends this  Registration  Statement on such date or dates
as may be necessary to delay its effective date until the Registrant  shall file
a further amendment which specifically  states that this Registration  Statement
shall  thereafter  become  effective  in  accordance  with  Section  8(a) of the
Securities  Act of  1933  or  until  the  Registration  Statement  shall  become
effective on such date as the  Commission,  acting pursuant to Section 8(a), may
determine.







<PAGE>




                                     PART II

             INFORMATION NOT REQUIRED IN PROSPECTUS/PROXY STATEMENT


Item 21.  Exhibits and Financial Statement Schedules.

         (a) The exhibits to the Registration  Statement required by Item 601 to
Regulation S-K are listed in the index to exhibits  following the signature page
of this Registration Statement.

         (b) All schedules are omitted  because of the absence of the conditions
under which they are required or because the required information is included in
the financial statements or related notes.

         (c)      Not applicable.


                                                  Part II - 1

<PAGE>



                                   SIGNATURES

         Pursuant to the  requirements of the Securities Act, the Registrant has
duly caused this  amendment to this  Registration  Statement to be signed on its
behalf by the undersigned,  thereunto duly authorized, in the city of Beaverton,
state of Oregon, on March 17, 1997.

                                         EPITOPE, INC.

                                         By /s/ GILBERT N. MILLER
                                              Gilbert N. Miller,
                                              Executive Vice President
                                              and Chief Financial Officer

         Pursuant  to the  requirements  of the  Securities  Act of  1933,  this
amendment to this  Registration  Statement has been signed on March 17, 1997, by
the following persons in the capacities indicated.

<TABLE>
<CAPTION>

Signature                                                    Title
- -----------                                                  -------

<S>                                                          <C>   
*ADOLPH J. FERRO, PH.D.                                      President, Chief Executive Officer
Adolph J. Ferro, Ph.D.                                       and Director
                                                             (Principal Executive Officer)

/s/ GILBERT N. MILLER                                        Executive Vice President,
Gilbert N. Miller                                            Chief Financial Officer and Treasurer
                                                             (Principal Financial Officer)

*MARK V. ALLRED                                              Controller
Mark V. Allred                                               (Principal Accounting Officer)


*W. CHARLES ARMSTRONG                                        Director
W. Charles Armstrong


*RICHARD K. DONAHUE                                          Director
Richard K. Donahue


*ANDREW S. GOLDSTEIN                                         Director
Andrew S. Goldstein


*MARGARET H. JORDAN                                          Director
Margaret H. Jordan


*R. DOUGLAS NORBY                                            Director
R. Douglas Norby


*MICHAEL J. PAXTON                                           Director
Michael J. Paxton


                                                  Part II - 2

<PAGE>




*ROGER L. PRINGLE                                            Director
Roger L. Pringle


*G. PATRICK SHEAFFER                                         Director
G. Patrick Sheaffer

*By /s/ GILBERT N. MILLER
    Gilbert N. Miller
    (Attorney-in-Fact)
</TABLE>

                                                  Part II - 3

<PAGE>



                                                 INDEX TO EXHIBITS


Exhibit
Number      Exhibit
- -------     -------
2           Acquisition  and Merger  Agreement  among Epitope,  Inc.,  Thamscoe,
            Inc.,  Andrew and Williamson  Sales,  Co., and the  shareholders  of
            Andrew and  Williamson  Sales,  Co.,  dated as of  November 6, 1996.
            Incorporated  by  reference  to Exhibit 2 to the  Company's  Current
            Report on Form 8-K dated November 6, 1996.

3.1         Restated Articles of Incorporation,  as amended,  of the Registrant.
            Incorporated by reference to Exhibit 3.1 to the Registrant's Current
            Report on Form 8-K dated May 29, 1991.

3.2         Restated  Bylaws of the  Registrant.  Incorporated  by  reference to
            Exhibit 3.2 to the  Registrant's  Annual Report on Form 10-K for the
            fiscal year ended September 30, 1996 (the "1996 10-K").

4.1         Restated Articles of Incorporation,  as amended,  of the Registrant.
            Incorporated by reference to Exhibit 3.1 to the Registrant's Current
            Report on Form 8-K dated May 29, 1991.

4.2         Article V of Restated  Articles of  Incorporation  as proposed to be
            amended.  Included  in Part I as  Annex  II to the  Prospectus/Proxy
            Statement included in this Registration Statement.

4.3         Note Purchase  Agreement dated June 10, 1992, among Agritope,  Inc.,
            the Registrant, and certain investors. Copies of the agreements with
            individual investors shall be filed with the Commission upon request
            pursuant to Item 601,  Instruction 2.  Incorporated  by reference to
            Exhibit 4.2 to the  Registrant's  Quarterly  Report on Form 10-Q for
            the fiscal quarterly period ended June 30, 1992.

5           Opinion of  Miller,  Nash,  Wiener,  Hager & Carlsen  LLP  regarding
            legality of the Agritope Common Stock.*

8           Opinion of Miller,  Nash, Wiener,  Hager & Carlsen LLP regarding tax
            matters.*

10.1        Incentive Stock Option Plan of Registrant, as amended.  Incorporated
            by reference to Exhibit 10.1 to the  Registrant's  Annual  Report on
            Form 10-K for the fiscal  year ended  September  30, 1994 (the "1994
            10-K").

10.2        Amended and  Restated  Epitope,  Inc.,  1991 Stock Award Plan ("1991
            Plan"). Incorporated by reference to Exhibit 10.2 to the 1994 10-K.

10.3        Agritope,  Inc., 1992 Stock Award Plan. Incorporated by reference to
            Exhibit 10.3 to the Registrant's  Annual Report on Form 10-K for the
            fiscal year ended September 30, 1992 (the "1992 10-K").

10.4        Form of  Nonqualified  Stock  Option  Agreement  issued  to  certain
            officers and  directors of  Registrant  pursuant to Agritope,  Inc.,
            1992 Stock Award Plan.  Incorporated by reference to Exhibit 10.4 to
            the 1992 10-K.

10.5        Lease  dated  July  17,  1990,  among   Registrant,   Koll  Woodside
            Associates, a California general partnership, and Petula Associates,
            Ltd., an Iowa corporation. Incorporated by reference to Exhibit 10.5
            to the 1994 10-K.


                                                   Index - 1

<PAGE>



10.6        Fourth  Amendment  dated May 20, 1994, to Lease dated July 17, 1990,
            among Registrant,  Koll Woodside  Associates,  a California  general
            partnership,  and  Petula  Associates,  Ltd.,  an Iowa  corporation.
            Incorporated  by  reference  to  Exhibit  10.1  to the  Registrant's
            Quarterly  Report on Form 10-Q for the fiscal quarterly period ended
            June 30, 1994 ("June 1994 10-Q").

10.7        Business  Park  Lease  dated May 5,  1994,  among  Registrant,  Koll
            Woodside Associates,  a California general  partnership,  and Petula
            Associates, Ltd., an Iowa corporation.  Incorporated by reference to
            Exhibit 10.2 to the June 1994 10-Q.

10.8        Business Park Lease dated as of December 16, 1994, among Registrant,
            Petula  Associates,  Ltd.,  an Iowa  corporation,  and Koll Portland
            Associates,  a  California  general  partnership.   Incorporated  by
            reference to Exhibit 10.1 to the  Registrant's  Quarterly  Report on
            Form 10-Q for the fiscal quarterly period ended December 31, 1994.

10.9        Lease  Agreement dated as of October 15, 1993,  between  Kathryne L.
            Brown and Agrimax Floral Products, Inc. Incorporated by reference to
            Exhibit 10.1 to the  Registrant's  Quarterly Report on Form 10-Q for
            the fiscal  quarterly period ended December 31, 1993 ("December 1993
            10-Q").

10.10       Office/Warehouse  Lease dated as of August 25, 1994,  between  Tonka
            Bay  Associates as agent for M Corp. of Illinois and Agrimax  Floral
            Products,  Inc.  Incorporated  by reference to Exhibit  10.10 to the
            1994 10-K.

10.11       Lease dated as of December 12, 1996,  between  Williamson and Andrew
            and Andrew and Williamson  Sales,  Co.  Incorporated by reference to
            Exhibit 10.12 to the 1996 10-K.

10.12       Agreement  dated  December 9, 1987,  between  Registrant  and Adolph
            Ferro,  Ph.D.  Incorporated  by  reference  to  Exhibit  4.3  to the
            Registrant's  Registration Statement on Form S-1 (No. 33-18722) (the
            "1988 S-1").

10.13       Amendment to Agreement of December 9, 1987,  between  Registrant and
            Adolph J. Ferro, Ph.D. Incorporated by reference to Exhibit 10.14 to
            the 1996 10-K.

10.14       Distribution Agreement dated as of April 1, 1994, between Registrant
            and  Organon  Teknika  Corporation.  Incorporated  by  reference  to
            Exhibit 10.3 to the June 1994 10-Q.

10.15       Supply Agreement dated as of April 1, 1994,  between  Registrant and
            Organon  Teknika  Corporation.  Incorporated by reference to Exhibit
            10.4 to the June 1994 10-Q.

10.16       Superior Tomato Associates,  L.L.C.  Operating Agreement dated as of
            February 19, 1996,  among  Sunseeds  Company,  Andrew and Williamson
            Sales, Co., and Agritope,  Inc. Incorporated by reference to Exhibit
            10.18 to the 1996 10-K.

10.17       Development  and Marketing  Agreement dated as of February 19, 1996,
            among Superior Tomato Associates,  L.L.C.,  Agritope, Inc., Sunseeds
            Company,  and Andrew  and  Williamson  Sales,  Co.  Incorporated  by
            reference to Exhibit 10.19 to the 1996 10-K.

10.18       Form of Indemnification Agreement for directors and officers.*

10.19       Amended and Restated  Employment  Agreement  dated  January 8, 1991,
            between  Andrew  S.  Goldstein  and   Registrant.   Incorporated  by
            reference to Exhibit 10.28 to the Registrant's Annual Report on Form
            10-K for the year ended September 30, 1991 (the "1991 10-K").

10.20       Amended and Restated  Employment  Agreement  dated  January 9, 1991,
            between Adolph J. Ferro,  Ph.D.,  and  Registrant.  Incorporated  by
            reference to Exhibit 10.29 to the 1991 10-K.


                                                   Index - 2

<PAGE>


10.21       Employment  Agreement  dated  January 28, 1990,  between  Gilbert N.
            Miller and Registrant. Incorporated by reference to Exhibit 10.19 to
            the 1994 10-K.

10.22       Employment  Agreement  dated July 1, 1990,  between John H. Fitchen,
            M.D. and  Registrant.  Incorporated by reference to Exhibit 10.20 to
            the 1994 10-K.

10.23       Employment  Agreement  dated July 15, 1995,  between Byron A. Allen,
            Jr., and  Registrant.  Incorporated by reference to Exhibit 10.23 to
            the  Registrant's  Annual  Report on Form 10-K for the  fiscal  year
            ended September 30, 1995.

10.24       Employment Agreement dated May 31, 1995, between Joseph A. Bouckaert
            and Vinifera, Inc.*

10.25       Employment  Agreement  dated  August 17,  1992,  between  Richard K.
            Bestwick, Ph.D., and Agritope, Inc.*

10.26       Employment  Agreement  dated  December  12,  1996,  between  Fred L.
            Williamson  and Andrew and Williamson  Sales,  Co.  Incorporated  by
            reference to Exhibit 10.28 to the 1996 10-K.

10.27       Credit  Agreement  dated August 5, 1996,  between  Wells Fargo Bank,
            National   Association   and  Andrew  and  Williamson   Sales,   Co.
            Incorporated by reference to Exhibit 10.29 to the 1996 10-K.

10.28       Development,  License and Supply  Agreement  between  Registrant and
            SmithKline Beecham plc dated February 24, 1995, as amended. Portions
            of  this  agreement  have  been  granted   confidential   treatment.
            Incorporated  by reference to Exhibit 10.1 to Amendment No. 2 to the
            Registrant's  Quarterly Report on Form 10-Q for the fiscal quarterly
            period ended June 30, 1995.

21          The  Registrant's   subsidiaries  are  Agritope,   Inc.,  an  Oregon
            corporation,  Vinifera,  Inc.,  an Oregon  corporation,  Andrew  and
            Williamson Sales, Co., a California corporation,  and Agrimax Floral
            Products, Inc., a Minnesota corporation.  The Registrant also owns a
            67 percent  interest  in  Strategic  Tomato  Associates,  L.L.C.,  a
            Delaware  limited  liability  company,  and a 60 percent interest in
            Epitope KK, a Japanese limited liability company.

23.1        Consent of Price Waterhouse LLP.*

   
23.2        Consent of Boros and Farrington.
    

23.3        Consents of Miller,  Nash, Wiener,  Hager & Carlsen LLP. Included in
            Exhibits 5 and 8.

24          Powers of Attorney.*

99          Form of proxy.*


Other exhibits listed in Item 601 of Regulation S-K are not applicable.


*Previously filed.




                                  EXHIBIT 23.2


                       Consent of Independent Accountants



We hereby  consent to the use in the Prospectus  constituting  part of amendment
No. 4 to the Registration  Statement on Form S-4 of Epitope, Inc., to our report
dated  November 6, 1996,  relating  to the  financial  statements  of Andrew and
Williamson  Sales,  Co.,  which  are  referenced  in  such  Form  S-4 and to the
references to us under the headings "Experts" and "Independent Accountants."

We also consent to the incorporation by reference in the Prospectus constituting
part of the  Registration  Statements on Form S-3 (Numbers  33-68510,  33-67618,
33-57246,  33-52920,  33-42841,  33-39166,  and  33-32673),  Form  S-8  (Numbers
33-63106,  33-63220,  33-63218,  33-41712,  33-13416,  33-21545,  33-82788,  and
33-60789),  and Form S-4 (Number 333-15705) of Epitope, Inc. of our report dated
November 6, 1996.




Boros & Farrington
February 25, 1997






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