EPITOPE INC/OR/
8-K, 1997-12-30
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                                -----------------

                                    FORM 8-K

                                 CURRENT REPORT

                       Pursuant to Section 13 or 15(d) of
                       the Securities Exchange Act of 1934

                Date of Report (Date of earliest event reported):

                                December 24, 1997

                                -----------------


                                  EPITOPE, INC.
               (Exact name of Registrant as specified in charter)

                                     Oregon
                 (State or other jurisdiction of incorporation)

                                     1-10492
                              (Commission File No.)

                                   93-0779127
                        (IRS Employer Identification No.)

     8505 S.W. Creekside Place                                     97008
           Beaverton, Oregon                                     (Zip Code)
  (Address of principal executive offices)

               Registrant's telephone number, including area code:

                                 (503) 641-6115





<PAGE>



Item 5.        Other Events

               On  December  24 and  December  29,  1997,  Epitope,  Inc.  ("the
Company"),  issued  press  releases  announcing  that  the  record  date for the
spin-off of Agritope,  Inc., would be December 26, 1997 (the "Record Date"), and
providing other information regarding the spin-off. Copies of the press releases
are attached to this form as exhibits.

               Pursuant to resolutions  adopted by the Board of Directors of the
Company,  the Company also issued a dividend  distribution of one Right for each
outstanding  share of common stock,  no par value (the "Common  Stock"),  of the
Company to the  shareholders  of record at the close of  business  on the Record
Date.  Each Right  entitles the  registered  holder to purchase from the Company
1/1,000 of a share of Series A Junior Participating  Cumulative Preferred Stock,
no par  value  (the  "Preferred  Shares"),  at a  price  of $60 per  share  (the
"Purchase  Price"),  subject to  adjustment.  The  description  and terms of the
Rights are set forth in a Rights  Agreement dated December 15, 1997 (the "Rights
Agreement"),  between the Company and ChaseMellon Shareholder Services,  L.L.C.,
as Rights Agent (the "Rights Agent").

               Initially,  the  Rights  will be  attached  to all  Common  Stock
certificates representing shares then outstanding,  and no separate certificates
evidencing Rights ("Right Certificates") will be distributed.  Until the earlier
of the close of business on (i) the tenth day after a public announcement that a
person or group of affiliated or associated  persons  (other than the Company or
its employee benefit plans) (an "Acquiring Person"),  acquired,  or obtained the
right to acquire,  beneficial ownership of 15 percent or more of the outstanding
shares of Common  Stock and (ii) the tenth  business  day (or such later date as
may be determined by the Board of Directors)  after the  commencement of (or the
announcement  of an  intention  to make) a tender  offer or  exchange  offer the
consummation  of which would result in the  beneficial  ownership by a person or
group of 15  percent  or more of the  outstanding  shares of Common  Stock,  the
Rights will be evidenced,  with respect to any of the Common Stock  certificates
outstanding  as of the Record  Date,  by such  Common  Stock  certificates.  The
earlier of the dates  described  in clauses (i) and (ii) above is referred to as
the "Distribution Date."

               Until the Distribution  Date, the Rights will be transferred with
and only with the Common Stock. As long as the Rights are attached to the Common
Stock,  the  Company  will issue one Right with each share of Common  Stock that
becomes  outstanding so that all outstanding  shares will have attached  Rights.
Until the  Distribution  Date (or the earlier  redemption  or  expiration of the
Rights),  (i)  Common  Stock  certificates  issued  after the  Record  Date upon
transfer or new issuance of Common Stock will contain a legend incorporating the
Rights  Agreement  by  reference  and (ii) the  surrender  for  transfer  of any
certificates  evidencing  Common Stock will also  constitute the transfer of the
Rights associated with the Common Stock represented by such certificate. As soon
as practicable  following the  Distribution  Date,  Right  Certificates  will be
mailed to holders of record of


                                      - 2 -
<PAGE>


the Common Stock as of the close of business on the  Distribution  Date and such
separate Right Certificates alone will evidence the Rights.

               The Rights are not exercisable  until the Distribution  Date. The
Rights will expire (i) at the close of business on December 26, 2007,  (ii) upon
exchange by the  Company  for Common  Stock as  described  below,  or (iii) upon
redemption by the Company as described below, whichever is earliest.

               In the event that any person becomes an Acquiring Person,  proper
provision  shall be made so that each  holder  of a Right  (except  as  provided
below) will  thereafter  have the right to receive upon  exercise that number of
shares of Common  Stock of the  Company  having a market  value of two times the
exercise  price of the Right.  No such  adjustment  to the Rights  will be made,
however,  if a person  becomes  an  Acquiring  Person  pursuant  to a tender  or
exchange offer for all outstanding Common Stock at a price and on terms that are
fair to and otherwise in the best interests of the Company and its shareholders,
as determined by a majority of the Board of Directors in the manner described in
the Rights Agreement (a "Qualifying Offer").

               In the event that, after any person becomes an Acquiring  Person,
the Company is acquired in a merger or other  business  combination  transaction
(other  than a  transaction  made  pursuant  to a  Qualifying  Offer and meeting
certain other requirements  described in the Rights Agreement),  or more than 50
percent of its assets or earning power is sold,  proper  provision shall be made
so that each holder of a Right (except as provided  below) will  thereafter have
the right to receive,  upon the exercise at the then current  exercise  price of
the Right,  that number of shares of common stock of the  acquiring or surviving
company having a market value of two times the exercise price of the Right.

               Following the  occurrence  of any of the events  described in the
preceding  two  paragraphs  (other  than those  events  relating  to  Qualifying
Offers),  any Rights that are or (under certain  circumstances  specified in the
Rights  Agreement)  were,  beneficially  owned  by any  Acquiring  Person  shall
immediately become null and void.

               The Purchase Price payable, and the number of Preferred Shares or
other securities or property  issuable,  upon exercise of the Rights are subject
to adjustment from time to time to prevent dilution.

               The Company is not required to issue fractional  Preferred Shares
other than  fractions in multiples of 1/1,000 of a share.  In lieu of fractional
Preferred Shares, an adjustment in cash may be made based on the market price of
the Preferred Shares on the last trading date prior to the date of exercise.

               At any time  prior to the tenth day  following  the first  public
announcement of the existence of an Acquiring Person, the Company may redeem the
Rights in whole, but


                                      - 3 -
<PAGE>


not in part, at a price of $.01 per Right (the "Redemption Price").  Immediately
upon the action of the Board of Directors  ordering the redemption of the Rights
(or at such time and date thereafter as the Board of Directors may specify), the
right to exercise the Rights will terminate and the only right of the holders of
Rights will be to receive the Redemption Price.

               At any time after a person becomes an Acquiring  Person and prior
to the  acquisition  by  such  Acquiring  Person  of 50  percent  or more of the
outstanding  shares of Common Stock,  the Company may exchange the Rights (other
than Rights  beneficially  owned by such Acquiring  Person which became null and
void), in whole or in part, for Common Stock at the rate of one share per Right,
subject to adjustment.

               Until a Right is exercised,  the holder  thereof,  as such,  will
have no rights as a shareholder of the Company,  including,  without limitation,
the right to vote or to receive dividends.

               Prior to the time a  person  becomes  an  Acquiring  Person,  the
provisions  of the Rights  Agreement  may be amended in any manner.  Thereafter,
with certain  exceptions,  the provisions of the Rights Agreement may be amended
in order to cure any ambiguity,  defect or inconsistency,  to make changes which
do not  adversely  affect the  interests  of holders  of Rights  (excluding  the
interest of any  Acquiring  Person),  or to shorten or lengthen  any time period
under the Rights Agreement;  provided,  however, that no amendment to adjust the
time period  governing  redemption  shall be made at such time as the Rights are
not redeemable.

               The Rights have certain  anti-takeover  effects.  The Rights will
cause  substantial  dilution  to a person or group of persons  that  attempts to
acquire  the  Company,  other  than in a  transaction  approved  by the Board of
Directors  of the Company at a time when the Rights are  redeemable.  The Rights
should not interfere with any acquisition,  merger or other business combination
approved by the Board of Directors at a time when the Rights are redeemable.

               The Rights Agreement and the Restated  Articles of Incorporation,
as  amended,  setting  forth  the  terms of the  Preferred  Shares  are filed as
exhibits to this report and are incorporated herein by reference.  The foregoing
description  of the Rights does not purport to be complete  and is  qualified in
its entirety by reference to the Rights  Agreement and the Restated  Articles of
Incorporation, as amended.


                                      - 4 -
<PAGE>



Item 7.        Financial  Statements,   Proforma  Financial   Information,   and
               Exhibits

               (c)     Exhibits.

               The  exhibits  filed  herewith  are listed in the  exhibit  index
following the signature page of this report.


                                      - 5 -
<PAGE>



                                   SIGNATURES


               Pursuant to the  requirements  of the Securities  Exchange Act of
1934,  the  Registrant has duly caused this report to be signed on its behalf by
the undersigned hereunto duly authorized.

                                            EPITOPE, INC.



Dated:  December 29, 1997                   By: /s/ Charles E. Bergeron
                                                    Charles E. Bergeron
                                                    Vice President of Operations


<PAGE>


                                  EXHIBIT INDEX


       3       Restated Articles of Incorporation,  as amended, of Epitope, Inc.
               Incorporated  by  reference  to  Exhibit  3  to  Epitope,  Inc.'s
               Registration  Statement on Form 8-A filed December 26, 1997 (File
               No. 000-15337) (the "Form 8-A").


       4       Rights Agreement dated as of December 15, 1997,  between Epitope,
               Inc., and ChaseMellon Shareholder Services,  L.L.C.  Incorporated
               by reference to Exhibit 4.1 to the Form 8-A.

      99.1     Description of Capital Stock of Epitope, Inc.

      99.2     Press  release issued December 24, 1997.

      99.3     Press release issued December 29, 1997.


                  DESCRIPTION OF CAPITAL STOCK OF EPITOPE, INC.



         The  articles  of  incorporation  (the  "Articles")  of  Epitope,  Inc.
("Epitope")  authorize the issuance of up to 30 million  shares of common stock,
no par value ("Epitope Common"), and 1 million shares of preferred stock, no par
value ("Epitope  Preferred"),  issuable in series. The following  description of
Epitope's  capital  stock is  qualified  in all  respects  by  reference  to the
Articles.


EPITOPE COMMON

         The holders of Epitope Common are entitled to one vote per share on all
matters on which  shareholders  are entitled to vote.  Holders of Epitope Common
are entitled to receive dividends when and as declared by the Board of Directors
of Epitope (the "Epitope  Board") out of any funds lawfully  available  therefor
and, in the event of  liquidation  or  distribution  of assets,  are entitled to
participate  ratably in the  distribution of such assets remaining after payment
of liabilities,  in each case subject to any preferential  rights granted to any
series of Epitope  Preferred  that may then be  outstanding.  Holders of Epitope
Common do not have cumulative voting rights with respect to any matter.

EPITOPE PREFERRED

         The Articles authorize the Epitope Board,  without further  shareholder
authorization,  to issue Epitope  Preferred in one or more series and to fix the
preferences,  limitations,  and relative rights of the Preferred Stock or of any
series thereof,  including  dividend rights and preferences,  conversion rights,
voting  rights,   redemption  rights,  and  rights  on  liquidation,   including
preferences over Epitope Common,  all of which could adversely affect the rights
of holders of Epitope  Common.  The  issuance  of a series of Epitope  Preferred
under  certain  circumstances  could have the effect of delaying or preventing a
change of control of Epitope,  could adversely  affect the rights of the holders
of Epitope  Common,  may discourage  offers for Epitope Common at a premium over
market  price and may  adversely  affect the market price of, and the voting and
other rights of the holders of, Epitope Common.

         The Epitope  Board has  designated a series of 30,000 shares of Epitope
Preferred as Series A Junior  Participating  Cumulative  Preferred Stock, no par
value ("Series A Preferred Stock"). Each 1/1000 of a share of Series A Preferred
Stock has dividend,  liquidation and voting rights  substantially  equivalent to
that of one share of Epitope  Common,  except that  Series A Preferred  Stock is
entitled, after issuance, to a minimum quarterly dividend of $1 per share and to
a minimum liquidation preference of $1 per share.

         The Epitope Board has adopted a  Shareholder  Rights Plan, as described
below, which enables holders of Epitope Common, under certain circumstances,  to
purchase  fractional shares of Series A Preferred Stock. See "Shareholder Rights
Plan," below. No Epitope


                                     - 1 -
<PAGE>


Preferred is currently  outstanding,  and Epitope has no present  plans to issue
any shares of Epitope Preferred.

PREEMPTIVE RIGHTS

         The Articles  provide  that no  shareholder  shall have any  preemptive
right to acquire  additional  shares of  Epitope,  whether of shares  originally
authorized or other shares which may subsequently be authorized.

SHAREHOLDER RIGHTS PLAN

         In December 1997,  Epitope entered into a shareholder  rights agreement
(the  "Rights  Agreement").  Under the Rights  Agreement,  each share of Epitope
Common shall initially have attached to it one preferred stock purchase right (a
"Right").

         Each Right represents the right to purchase, if and when the Rights are
exercisable,  1/1,000  of a share of  Series A Junior  Participating  Cumulative
Preferred  Stock at an exercise  price of $60. The exercise price and the number
of shares  issuable  upon  exercise of the Rights are subject to  adjustment  in
certain  cases to prevent  dilution.  The Rights are  evidenced  by the  Epitope
Common  certificates  and are not  exercisable,  or transferable  apart from the
Epitope Common,  until the earlier of the close of business on (i) the tenth day
after a public  announcement  that a person or group of affiliated or associated
persons  (other  than  Epitope or its  employee  benefit  plans) (an  "Acquiring
Person"), acquired, or obtained the right to acquire, beneficial ownership of 15
percent or more of the  outstanding  shares of Epitope Common and (ii) the tenth
business  day (or such later date as may be  determined  by the  Epitope  Board)
after the commencement of (or the announcement of an intention to make) a tender
offer or exchange offer the consummation of which would result in the beneficial
ownership by a person or group of 15 percent or more of the  outstanding  shares
of Epitope  Common (the  earlier of the dates  described in clauses (i) and (ii)
above is  referred  to as the  "Distribution  Date").  In the event  any  person
becomes an Acquiring  Person,  each of the Rights (other than Rights held by the
Acquiring  Person and certain of its  transferees,  all of which will be voided)
entitles the holder to acquire  Epitope Common having a value equal to twice the
Right's exercise price.

         In the  event  Epitope  is  acquired  in a  merger  or  other  business
combination  transaction  (including  one in  which  Epitope  is  the  surviving
corporation),  each  Right will  entitle  its  holder to  purchase,  at the then
current  exercise  price of the Right,  that number of shares of common stock of
the surviving  company which at the time of such transaction would have a market
value of two times the exercise  price of the Right.  The Rights do not have any
voting rights and are redeemable,  at the option of Epitope, at a price of $0.01
per  Right at any  time  prior to the  tenth  day  following  the  first  public
announcement of the existence of an Acquiring Person.


                                      - 2 -
<PAGE>



         The Rights  expire on December 26, 2007.  So long as the Rights are not
separately  transferable,  Epitope  will  issue one Right with each new share of
Epitope Common issued.

         The Rights have certain  anti-takeover  effects.  The Rights will cause
substantial  dilution to a person or group that  attempts to acquire  Epitope on
terms not approved by the

Epitope Board. The Rights should not interfere with any merger or other business
combination  approved by the Epitope Board because the Rights may be redeemed by
Epitope until the tenth  business day  following  the first public  announcement
that a person or group has become an Acquiring Person.

OTHER ANTI-TAKEOVER MEASURES

         Epitope's bylaws (the "Bylaws") and Articles contain certain provisions
that may have the  effect  of  delaying,  deferring  or  preventing  a change in
control of Epitope.  Such  provisions,  explained in more detail below,  include
requirements for: (i) a classified board of directors; (ii) removal of directors
only by supermajority shareholder vote; and (iii) advance notice with respect to
nominations of directors other than by or at the direction of the Epitope Board.

         Classified  Board of Directors.  The Articles  provide that the Epitope
Board will be divided into three classes  (Class I, Class II and Class III) with
each class  containing  as nearly as possible  one-third  of the total number of
directors and the members of each class serving for staggered  three-year terms.
At each annual meeting of Epitope shareholders, the number of directors equal to
the number of the class whose term  expires at the time of such  meeting will be
elected to hold  office  until the third  succeeding  annual  meeting of Epitope
shareholders.

         Removal of  Directors.  Directors of Epitope may be removed only by the
vote of at  least 90  percent  of the  votes  then  entitled  to be cast for the
election of directors.

         Nominations of Directors by  Shareholders.  The Bylaws require that, in
addition to other applicable requirements,  a shareholder generally may nominate
a person for election to the Epitope  Board at a meeting only if written  notice
of such  shareholder's  intent to make such nomination has been given to Epitope
not later than (a) with  respect to an election to be held at an annual  meeting
of  shareholders,  60 days in advance of the date of the previous  year's annual
meeting of  shareholders,  and (b) with  respect to an  election to be held at a
special  meeting of  shareholders  for the election of  directors,  the close of
business on the seventh day  following  the date on which notice of such meeting
is first given to shareholders.  Moreover, in order to be valid, any such notice
must be in proper written form as more specifically described in the Bylaws.

         Amendment of Articles.  The Articles require the affirmative vote of at
least 90 percent of the votes then entitled to be cast for election of directors
to  amend  certain   provisions  of  the  Articles   including  certain  of  the
anti-takeover measures described above.


                                      - 3 -
<PAGE>


OREGON ANTI-TAKEOVER STATUTES

         Epitope  is  subject  to  certain  provisions  of the  Oregon  Business
Corporation  Act that govern  business  combinations  between  corporations  and
interested   shareholders  (the  "Business   Combination   Act").  The  Business
Combination  Act  generally  provides  that,  if a person or entity  acquires 15
percent or more of the voting  stock of an Oregon  corporation  (an  "Interested
Shareholder"), the corporation and the Interested Shareholder, or any affiliated
entity  of the  Interested  Shareholder,  may not  engage  in  certain  business
combination transactions for three years following the date the person became an
Interested  Shareholder.  Business  combination  transactions  for this  purpose
include: (a) a merger or plan of share exchange;  (b) any sale, lease,  mortgage
or other disposition of 10 percent or more of the assets of the corporation; and
(c) certain  transactions  that result in the  issuance of capital  stock to the
Interested  Shareholder.  These restrictions do not apply if: (i) the Interested
Shareholder,  as a result of the  transaction  in which  such  person  became an
Interested Shareholder, owns at least 85 percent of the outstanding voting stock
of the corporation (disregarding shares owned by directors who are also officers
and shares owned by certain employee benefit plans); (ii) the board of directors
approves the share  acquisition  or business  combination  before the Interested
Shareholder acquires 15 percent or more of the corporation's  outstanding voting
stock; or (iii) the board of directors and the holders of at least two-thirds of
the outstanding  voting stock of the corporation  (disregarding  shares owned by
the  Interested  Shareholder)  approve  the  transaction  after  the  Interested
Shareholder acquires 15 percent or more of the corporation's voting stock.

         Epitope is also subject to the Oregon  Control  Share Act (the "Control
Share  Act").  The  Control  Share Act  generally  provides  that a person  (the
"Acquiror") who acquires voting stock of an Oregon  corporation in a transaction
which results in the Acquiror holding more than 20 percent, 33-1/3 percent or 50
percent  of  the  total  voting  power  of the  corporation  (a  "Control  Share
Acquisition")   cannot  vote  the  shares  it  acquires  in  the  Control  Share
Acquisition  ("Control Shares") unless voting rights are accorded to the Control
Shares by: (a) a majority of each  voting  group  entitled to vote;  and (b) the
holders of a majority of the  outstanding  voting shares,  excluding the Control
Shares held by the  Acquiror and shares held by the  corporation's  officers and
inside  directors.  The term  "Acquiror" is broadly  defined to include  persons
acting as a group.

         The Acquiror may, but is not required to, submit to the  corporation an
"Acquiring  Person  Statement"  setting  forth  certain  information  about  the
Acquiror  and its plans with respect to the  corporation.  The Acquiror may also
request that the corporation call a special meeting of shareholders to determine
whether  the voting  rights  will be  restored  to the  Control  Shares.  If the
Acquiror does not request a special meeting of shareholders, the issue of voting
rights of  Control  Shares  will be  considered  at the next  annual or  special
meeting  of  shareholders  that is held more than 60 days  after the date of the
Control Share Acquisition.  If the Acquiror's Control Shares are accorded voting
rights and represent a majority or more of all voting power, shareholders who do
not vote in favor of the  restoration  of such voting rights will have the right
to receive the  appraised  "fair value" of their  shares,  which may not be less
than the highest price paid per share by the Acquiror for the Control Shares.


                                      - 4 -



                      Record Date Set for Agritope Spin-Off

         BEAVERTON,  Ore., Dec. 24 /PRNewswire/ -- Epitope, Inc. (Nasdaq:  EPTO)
today  announced  that it has set December 26, 1997, as the record date on which
its  shareholders  will be eligible to receive a distribution of common stock of
Agritope,  Inc. For every five shares of common stock of Epitope,  Inc. held, as
of the close of business on December  26,  1997,  shareholders  will receive one
share of common stock of Agritope. Epitope shareholders will not have to pay for
any shares of  Agritope  stock  received in the  distribution  or take any other
action to receive shares.  In connection with the spin-off,  Agritope will issue
1.56 million  shares of capital  stock to certain  foreign  investors  for $10.9
million ($7 per share).

         "We believe that the spin-off of Agritope is the best way for Epitope's
shareholders to realize the value in both the  agricultural  and medical product
businesses  by creating two  separate  and  independent  public  companies.  The
spin-off will allow management of each company to focus on the unique challenges
of each industry,  without  distractions  from the other business," said John W.
Morgan,  president and chief executive officer of Epitope.  "We are pleased that
outside investors and a strategic partner,  who recognize the value of Agritope,
have agreed to provide the capital needed to support  Agritope's  operation as a
separate business."

         Agritope has filed a  registration  statement  with the  Securities and
Exchange  Commission  with  respect  to  the  shares  to be  distributed  in the
spin-off.  An  information   statement/prospectus  will  be  furnished  to  each
shareholder of record as of the close of business on December 26, 1997.

         Epitope expects to deliver the information statement/prospectus and the
Agritope shares on or about January 8, 1998.

         Epitope  currently  has  13,454,330  shares  outstanding.  Accordingly,
Epitope expects to distribute  2,690,866  Agritope  shares to its  shareholders.
Upon completion of the  distribution,  Agritope will cease to be a subsidiary of
Epitope and will operate as an independent public company.  Agritope shares will
trade on the SmallCap tier of the Nasdaq Stock Market under the symbol AGTO.

         On December 31, 1997,  Agritope will issue 1,343,704 shares of Agritope
common  stock at a price of $7 per share to  certain  foreign  investors  for an
aggregate sales price of $9.4 million. In early January 1998, Agritope will also
issue,  for an  aggregate  sales price of $1.5  million  ($7 per share)  214,285
shares of its preferred stock to Vilmorin & Cie., a majority owned subsidiary of
Groupe Limagrain  Holdings,  Chappes,  France.  Vilmorin also holds an option to
purchase up to additional  785,715 shares of Agritope preferred stock, also at a
price of $7 per share.  The option expires January 15, 1998. The preferred stock
is  convertible  into common stock on a  share-for-share  basis.  Other than the
right to elect a director and preemptive  rights, the preferred stock has rights
substantially equivalent to those applicable to common stock.

                                     (more)

<PAGE>

                                       -2-


         Under terms of a related research and development  agreement,  Vilmorin
will provide  proprietary  seed  varieties for use by Agritope in projects to be
funded by  Vilmorin,  in which both  Agritope  and  Vilmorin  technology  may be
applied.  Vilmorin  will also  have a right of first  refusal  to fund  research
projects involving the genetic modification of specified vegetables and flowers.

         Founded  in  1743,  Vilmorin  specializes  in the  worldwide  breeding,
production and distribution of vegetable and flower seeds to the home garden and
professional  markets.  It is the largest  company in the world serving the home
garden  market and the  second  largest in the world  serving  the  professional
vegetable seed market. Vilmorin's U.S. subsidiary,  Harris Moran Seed Company of
Modesto, California and Agritope have been working together for several years to
develop cantaloupe with a longer shelf life.

         Epitope  is  an  Oregon  company  that  develops  and  markets  medical
diagnostic  products.  Agritope is an  Oregon-based  agricultural  biotechnology
company  specializing in the  development of new fruit and vegetable  varieties.
Agritope is also the majority owner of Vinifera,  Inc.,  which offers  grapevine
plant propagation and disease screening and elimination programs.

         A  registration  statement  relating to the  securities to be issued to
Epitope  shareholders has been declared effective by the Securities and Exchange
Commission.  These  securities may not be sold nor may offers to buy be accepted
prior to the time the  registration  statement  becomes  effective.  This  press
release shall not constitute an offer to sell or the solicitation of an offer to
buy nor shall there be any sale of these  securities  in any state in which such
offer,  solicitation,  or sale  would  be  unlawful  prior  to  registration  or
qualification  under the securities  laws of any such state.  Shares of Agritope
stock  to be  sold to  Vilmorin  and  other  foreign  investors  have  not  been
registered under the Securities Act of 1933, as amended,  and may not be offered
or sold in the United States absent registration or an applicable exemption from
registration requirements.

SOURCE  Epitope, Inc.
         -0-                        12/24/97
         /CONTACT:  Mary  Hagen of  Epitope,  503-614-6115;  or Matt  Kramer  of
Agritope, 503-670-7702/
         /Company News On-Call:  http://www.prnewswire.com or fax, 800-758-5804,
ext. 285632/
         (EPTO AGTO)



FOR IMMEDIATE RELEASE                         Contact:         Mary Hagen
                                                               503.641.6115

                                                               Matt Kramer
                                                               503.670.7702


                EX-DIVIDEND DATE CLARIFIED FOR AGRITOPE SPIN-OFF

         BEAVERTON,  Ore.,  December 29, 1997 -- Epitope,  Inc.  (Nasdaq:  EPTO)
today  announced  that it has been  informed  by the Nasdaq  Stock  Market  that
Epitope common stock will commence  trading  ex-dividend on January 8, 1998. The
ex-dividend  date was  previously  reported  incorrectly as December 23, 1997 by
certain industry sources.

On January 7, 1998, the company will distribute a previously  announced dividend
of one share of common stock of Agritope,  Inc. for every five shares of Epitope
common stock held of record at the close of business on December 26, 1997.

From the record date  through the close of business on January 7, 1998,  Epitope
common  stock will trade with a due bill,  entitling  purchasers  to receive the
dividend of Agritope common stock.


Epitope is an Oregon  company  that  develops  and  markets  medical  diagnostic
products.   Agritope  is  an  Oregon-based  agricultural  biotechnology  company
specializing in the development of new fruit and vegetable varieties.

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