EPITOPE INC/OR/
10-Q, 1998-05-12
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549
                                -----------------

                                    FORM 10-Q
(Mark One)

[X] Quarterly report pursuant to section 13 or 15(d) of the Securities  Exchange
Act of 1934 for the quarter ended March 31, 1998
                                       OR
[ ] Transition report pursuant to Section 13 or 15(d) of the Securities Exchange
Act of 1934 for the transition period from ---- to -----.
                         Commission File Number 1-10492


                                  EPITOPE, INC.
             (Exact name of registrant as specified in its charter)

                              OREGON NO. 93-0779127
        (State or other jurisdiction of (IRS Employer Identification No.)
                         incorporation or organization)

                             8505 SW Creekside Place
                          Beaverton, Oregon 97008-7108
               (Address of principal executive offices) (Zip code)

                                 (503) 641-6115
              (Registrant's telephone number, including area code)


        Indicate by check mark whether the  registrant (1) has filed all reports
required to be filed by Section 13 or 15(d) of the  Securities  Exchange  Act of
1934  during  the  preceding  12 months  (or for such  shorter  period  that the
registrant  was required to file such  reports) and (2) has been subject to such
filing requirements for the past 90 days. Yes [X] No [ ]

        Number of shares of Common Stock, no par value,  outstanding as of March
31, 1998: 13,541,769



<PAGE>


================================================================================


                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549
                                ----------------

                                    FORM 10-Q






                QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(D)
                     OF THE SECURITIES EXCHANGE ACT OF 1934

                   FOR THE SECOND QUARTER ENDED MARCH 31, 1998



                         Commission File Number 1-10492


                                  EPITOPE, INC.



   Incorporated in                                       IRS Employer
 the State of Oregon                             Identification No. 93-0779127


                             8505 SW Creekside Place
                          Beaverton, Oregon 97008-7108

                                 (503) 641-6115






     Indicate  by check mark  whether the  registrant  (1) has filed all reports
required to be filed by Section 13 or 15(d) of the  Securities  Exchange  Act of
1934  during  the  preceding  12 months  (or for such  shorter  period  that the
registrant  was required to file such  reports) and (2) has been subject to such
filing requirements for the past 90 days. Yes [X] No [ ]

     Number of shares of Common Stock, no par value, outstanding as of March 31,
1998: 13,541,769

================================================================================


<PAGE>


                          PART I. FINANCIAL INFORMATION

<TABLE>
                                                                                             Page No.
                                                                                             --------
<S>                                                                                            <C>
Item 1.  Condensed Financial Statements.........................................                3
     Condensed Balance Sheets
         at March 31, 1998 and September 30, 1997...............................                3
     Condensed Statements of Operations
         for the three and six months ended March 31, 1998 and 1997 ............                4
     Condensed Statements of Changes in Shareholders' Equity
         for the three and six months ended March 31, 1998......................                5
     Condensed Statements of Cash Flows
         for the six months ended March 31, 1998 and 1997.......................                6

     Notes to Condensed Financial Statements....................................                7


Item 2.  Management's Discussion and Analysis of Financial Condition
     and Results of Operations .................................................                9


                           PART II. OTHER INFORMATION

Item 4. Submission of Matters to a Vote of Security Holders.....................               11

Item 5. Other Information.......................................................               11

Item 6.  Exhibits and Reports on Form 8-K.......................................               12
</TABLE>

                                       2
<PAGE>


EPITOPE, INC.

CONDENSED BALANCE SHEETS

<TABLE>
                                                                                   3/31/98                 9/30/97
                                                                                  (Unaudited)
ASSETS
Current assets
<S>                                                                              <C>                 <C>             
Cash and cash equivalents..............................................          $    579,303        $    1,934,480
Marketable securities..................................................             5,433,811             7,141,640
Trade accounts receivable, net ........................................               826,143               928,047
Other receivables......................................................               129,277               128,949
Inventories (Note 2) ..................................................             1,184,451             1,324,647
Prepaid expenses ......................................................               416,967                78,240
                                                                                  -----------         -------------
                                                                                    8,569,952            11,536,003

Property and equipment, net ...........................................               948,650             1,200,988
Patents and proprietary technology, net ...............................               604,211               657,487
Other assets and deposits..............................................                17,377                55,099
Net assets of discontinued operations (Note 3)...........................                   -             3,562,726
                                                                                  -----------         -------------

                                                                                 $ 10,140,190         $  17,012,303

LIABILITIES AND SHAREHOLDERS' EQUITY
Current liabilities
Accounts payable ......................................................          $    242,586         $     110,285
Salaries, benefits and other accrued liabilities ......................             1,710,416             1,887,825
                                                                                 ------------         -------------
                                                                                    1,953,002             1,998,110

Commitments and contingencies .........................................                    -                     -

Shareholders' equity (Note 4)
Contributed capital ...................................................           110,993,976           110,439,726
Accumulated deficit....................................................          (102,806,788)          (95,425,533)
                                                                                 ------------           -----------
                                                                                    8,187,188            15,014,193

                                                                                 $ 10,140,190          $ 17,012,303
</TABLE>

                                       3
<PAGE>


EPITOPE, INC.

CONDENSED STATEMENTS OF OPERATIONS (Unaudited)

<TABLE>
                                                        THREE MONTHS ENDED                  SIX MONTHS ENDED

                                                       3/31/98         3/31/97            3/31/98         3/31/97
Revenues
<S>                                                  <C>             <C>               <C>             <C>        
Product sales ..............................         $ 2,102,905     $ 2,152,208       $ 3,694,347     $ 4,511,359
Grants and contracts .......................                  -          183,729            11,381         465,339
                                                     -----------     -----------       -----------     -----------
                                                       2,102,905       2,335,937         3,705,728       4,976,698
Costs and expenses
Product costs ..............................             930,485         832,597         1,586,254       1,801,855
Research and development costs .............             617,898       1,063,057         1,297,745       1,867,030
Selling, general and administrative expenses           1,372,178       1,678,648         2,690,190       3,156,345
                                                     -----------     -----------       -----------     -----------
                                                       2,920,561       3,574,302         5,574,189       6,825,230

Loss from operations .......................            (817,656)     (1,238,365)       (1,868,461)     (1,848,532)

Other income (expense), net
Interest income.............................              86,332         257,528           201,227         576,862
Interest expense............................                 257               -            (7,416)              -
Other, net..................................              (2,835)         16,550           (14,588)         16,488
                                                     -----------     -----------       -----------     -----------
                                                          83,754         274,078           179,223         593,350

Net loss from continuing operations.........            (733,902)       (964,287)       (1,689,238)     (1,255,182)

Loss from discontinued operations...........                   -      (9,202,195)                -     (13,295,714)
                                                     -----------     -----------       -----------     -----------

Net loss....................................         $  (733,902)   $(10,166,482)      $(1,689,238)   $(14,550,896)

Basic and diluted loss per share
         from continuing operations.........         $     (0.05)   $      (0.07)      $     (0.13)   $      (0.09)

Basic and diluted net loss per share........         $     (0.05)   $      (0.74)      $     (0.13)   $      (1.09)

Weighted average number of shares outstanding         13,485,951      13,714,551        13,470,003      13,404,402
</TABLE>

                                       4
<PAGE>



EPITOPE, INC.

CONDENSED STATEMENTS OF CHANGES IN
   SHAREHOLDERS' EQUITY (Unaudited)

<TABLE>
                                                             COMMON STOCK                ACCUMULATED
                                                       SHARES            DOLLARS            DEFICIT            TOTAL

<S>                                                   <C>             <C>               <C>                <C>         
BALANCES AT SEPTEMBER 30, 1997................        13,454,330      $ 110,439,726     $ (95,425,533)     $ 15,014,193
Common stock issued as compensation...........             6,711             24,160                 -            24,160
Compensation expense for stock
    option grants.............................                 -            113,056                 -           113,056
Spin-off of Agritope, Inc. ...................                 -                  -        (5,692,017)       (5,692,017)
Net loss for the period.......................                 -                  -          (955,336)         (955,336)
                                                      ----------       ------------      -------------      ------------

BALANCES AT DECEMBER 31, 1997.................        13,461,041        110,576,942      (102,072,886)        8,504,056
Common stock issued upon exercise
    of options................................            75,619            313,721                 -           313,721
Common stock issued as compensation...........             5,109             35,582                 -            35,582
Compensation expense for stock
    option grants.............................                 -             67,731                 -            67,731
Net loss for the period.......................                 -                  -          (733,902)         (733,902)
                                                      ----------      -------------    --------------       ------------

BALANCES AT MARCH 31, 1998....................        13,541,769      $ 110,993,976     $(102,806,788)      $ 8,187,188
</TABLE>

                                       5
<PAGE>


EPITOPE, INC.

CONDENSED STATEMENTS OF CASH FLOWS (Unaudited)

<TABLE>
SIX MONTHS ENDED MARCH 31                                                             1998                1997

CASH FLOWS FROM OPERATING ACTIVITIES
<S>                                                                              <C>                   <C>          
Net loss ..............................................................          $ (1,689,238)         $(14,550,896)
Adjustments to reconcile net loss
   to net cash used in operating activities:
Loss from discontinued operations .....................................                     -            13,295,714
Depreciation and amortization .........................................               346,314               363,080
Decrease (increase) in accounts receivable and other receivables ......               101,576               (58,833)
Decrease (increase) in inventories ....................................               140,196              (284,614)
Increase in prepaid expenses ..........................................              (338,727)             (281,372)
(Decrease) increase in accounts payable and accrued liabilities .......               (45,108)              478,482
Common stock issued as compensation for services.......................                59,742                31,172
Compensation expense for stock option grants and
   deferred salary increases ..........................................               180,787               218,705
Other, net ............................................................                 8,448                 9,403
                                                                                -------------         -------------
Net cash used in operating activities..................................            (1,236,010)             (779,159)

CASH FLOWS FROM INVESTING ACTIVITIES
Investment in marketable securities ...................................            (7,663,044)          (13,806,816)
Proceeds from sale of marketable securities ...........................             9,373,294            19,820,785
Additions to property and equipment ...................................               (40,814)             (157,201)
Proceeds from sale of property and equipment...........................                37,629                    -
Expenditures for patents and proprietary technology ...................               (54,584)             (161,919)
Investment in affiliated companies ....................................                11,871            (7,133,147)
                                                                                -------------         --------------
Net cash provided by (used in) investing activities....................             1,664,352            (1,438,298)

CASH FLOWS FROM FINANCING ACTIVITIES
Proceeds from issuance of common stock ................................               313,721                48,008
Advances in connection with spin-off ..................................            (2,097,240)           (3,392,743)
                                                                                --------------        --------------
Net cash used in financing activities..................................            (1,783,519)           (3,344,735)

Net decrease in cash and cash equivalents .............................            (1,355,177)           (5,562,192)
Cash and cash equivalents at beginning of period ......................             1,934,480             5,699,263
                                                                                -------------         -------------
Cash and cash equivalents at end of period.............................         $     579,303         $     137,071
</TABLE>

                                       6
<PAGE>


NOTES TO CONDENSED FINANCIAL STATEMENTS (UNAUDITED)


NOTE 1   THE COMPANY

Epitope, Inc. (the Company or Epitope) is an Oregon corporation,  which develops
and markets medical diagnostic products. Epitope's principal products, including
the OraSure oral specimen  collection device,  focus on the use of oral fluid to
detect HIV infection  and other  conditions,  and are marketed  primarily in the
life insurance and public health sectors.

The  interim  condensed  financial  statements  included  herein are  unaudited;
however,  in  the  opinion  of  the  Company,   the  interim  data  include  all
adjustments,  consisting only of normal recurring  adjustments,  necessary for a
fair  statement  of the results of  operations  for the interim  periods.  These
condensed financial  statements should be read in conjunction with the financial
statements  and notes thereto  included in the  Company's  1997 Annual Report on
Form 10-K.  Results of  operations  for the periods ended March 31, 1998 are not
necessarily indicative of the results of operations expected for the full fiscal
year.


NOTE 2   SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

Basis  of  Presentation.  The  accompanying  financial  statements  include  the
accounts of the  Company  and its wholly  owned  subsidiaries.  All  significant
intercompany  balances and transactions  have been eliminated and the results of
the former Agritope,  Inc. subsidiary (Agritope) have been shown as discontinued
operations in the 1997 fiscal periods reported.

<TABLE>
Inventories.  Inventory components are summarized as follows:                        3/31/98               9/30/97
                                                                                   (Unaudited)

<S>                                                                               <C>                  <C>      
Raw materials..........................................................           $   389,875           $   296,432
Work-in-process .......................................................               358,157               343,585
Finished goods ........................................................               421,964               670,175
Supplies ..............................................................                14,455                14,455
                                                                                  -----------           -----------
                                                                                  $ 1,184,451           $ 1,324,647
</TABLE>

Net Loss Per  Share.  Net loss per share has been  computed  using the  weighted
average number of shares of common stock outstanding  during the period.  Common
stock  equivalents  were excluded from the  computation  because their effect is
anti-dilutive.

NOTE 3   DISCONTINUED OPERATIONS

On December  30,  1997,  the Company  distributed  all of its shares of Agritope
common stock to Epitope  shareholders  of record as of December  26,  1997.  The
costs of the  spin-off  and  Agritope's  operating  losses in  fiscal  1998 were
accounted  for in fiscal  year  1997.  The  comparable  periods  in fiscal  1997
included  the loss from  discontinued  operations  of  Agritope  and  Andrew and
Williamson Sales, Co. (A&W).

Bank Line of Credit.  In  connection  with the  acquisition  of A&W, the Company
guaranteed a bank line of credit  maintained by A&W. The $6.5 million  revolving
line is secured by A&W's accounts receivable, inventory and equipment. The terms
of  Epitope's  guarantee  require  that it maintain  certain  tangible net worth
levels.  The line of credit also contains  various  financial  covenants for A&W
including  minimum  working  capital and  tangible  net worth levels and maximum
debt-to-net  worth  ratios.  In  addition,  the  principals  of  A&W  have  each
personally  guaranteed  the line of credit.  A&W has  agreed  that  Epitope  may
terminate its guaranty as to future  advances unless A&W has obtained a new line
of credit not guaranteed by Epitope by November 1, 1998. The balance outstanding
under the line was  $1,138,000 as of March 31, 1998. In April 1998,  Wells Fargo
Bank N.A. extended the maturity date of the credit agreement to June 5, 1998.

                                       7
<PAGE>


NOTE 4   SHAREHOLDERS' EQUITY

The costs of the spin-off and  Agritope's  operating  losses in fiscal 1998 were
accounted for in fiscal 1997 as expenses of discontinued operations. The overall
reduction  in retained  earnings  as a result of the  spin-off  was  $5,692,017,
including  spin-off  related costs. No additional  material charges are expected
related to the Agritope spin-off.





                                       8
<PAGE>


Item 2.       MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION
              AND RESULTS OF OPERATIONS

The following discussion of operations and financial condition should be read in
conjunction  with the Financial  Statements  and Notes  thereto  included in the
Company's 1997 Annual Report on Form 10-K and with the Financial  Statements and
Notes thereto  included in this  Quarterly  Report on Form 10-Q.  Statements set
forth below  about  future  events or  performance  constitute  "forward-looking
statements" within the meaning of the Private  Securities  Litigation Reform Act
of 1995.  The  forward-looking  statements  involve  known  and  unknown  risks,
uncertainties  and other factors that may cause the actual results,  performance
or  achievements of the Company or industry  results to be materially  different
from any future results, performance or achievements expressed or implied by the
forward-looking  statements.  These factors with respect to the Company  include
loss or  impairment  of sources of  capital;  ability of the  Company to develop
diagnostic product  distribution  channels;  development of competing diagnostic
products,  including blood and urine-based  products;  market acceptance of oral
testing products;  changes in federal or state law or regulations  applicable to
diagnostic  products or their manufacture and marketing;  loss of key personnel;
and other factors as described in the Company's 1997 Annual Report on Form 10-K.
Although  forward-looking  statements help to provide complete information about
the Company,  readers  should keep in mind that  forward-looking  statements are
much less reliable than historical information.


RESULTS OF OPERATIONS

Revenues.  Total revenues decreased by $233,000 or 10% in the current quarter as
compared with the second quarter of fiscal 1997, and by $1,271,000 or 26% in the
comparable six-month period. Revenues by product line are shown below:

<TABLE>
THREE MONTHS ENDED MARCH 31 (IN THOUSANDS, EXCEPT %)                        1998                       1997
                                                                      DOLLARS    PERCENT        DOLLARS    PERCENT
Product sales
<S>                                                                  <C>          <C>           <C>        <C>
   Oral collection device.................................           $ 1,624       77%          $ 1,676      72%
   Western blot HIV confirmatory test.....................               479       23               476      20
                                                                     -------     ----           -------    ----
                                                                       2,103      100             2,152      92
Grants and contracts......................................                -        -                184       8
                                                                     -------     ----           -------    ----
                                                                     $ 2,103      100%          $ 2,336     100%

SIX MONTHS ENDED MARCH 31 (IN THOUSANDS, EXCEPT %)                          1998                       1997
                                                                      DOLLARS    PERCENT        DOLLARS    PERCENT
Product sales
   Oral collection device.................................           $ 2,754       74%          $ 3,576      72%
   Western blot HIV confirmatory test.....................               940       25               935      19
                                                                     -------     ----           -------    ----
                                                                       3,694       99             4,511      91
Grants and contracts......................................                11        1               466       9
                                                                    --------     ----           -------    ----
                                                                     $ 3,705      100%          $ 4,977     100%
</TABLE>


Sales of the Company's  OraSure oral  specimen  collection  device  decreased by
$52,000 or 3% in the current quarter as compared to the second quarter in fiscal
1997, and by $822,000 or 23% in the comparable six-month period. The decrease is
attributable to inventory build-up in the first three quarters of fiscal 1997 by
major testing  laboratories as insurance  companies made initial decisions about
adoption of the  Company's  OraSure(R)  device and expansion of use beyond pilot
programs.  This  inventory  build-up  resulted  in reduced  sales to the testing
laboratories in the most recent three fiscal quarters as the laboratories worked
down their  inventory  levels.  By the third  quarter of fiscal 1998,  inventory
levels are expected to be in line with  current  customer  requirements.  As the
Company expands into the public health markets,  it is anticipated  that overall
sales for the  remainder  of the year will exceed those of the first six months.
Expectations  for future sales are based  primarily  on forecasts by  individual
customers  rather  than firm  orders,  as many of the smaller  customers  in the
public health market do not have contractual  arrangements with the Company. The
Company's sales for OraSure products,  including cotinine test devices, continue
to expand in foreign markets.

                                       9
<PAGE>

Sales of the Company's Western blot HIV confirmatory test increased  slightly in
the current  quarter  and  six-month  period as compared to the same  periods in
fiscal  1997.  As of  March  31,  1998,  the  Company  had firm  orders  for the
confirmatory HIV test totaling  $600,000  scheduled for shipment before June 30,
1998.

Grant and contract revenues decreased by $184,000 or 100% in the current quarter
as compared to the second  quarter of fiscal 1997, and by $454,000 or 98% in the
comparable  six-month  period,  primarily due the  termination  of the Company's
Development,  License and Supply  Agreement with its former  strategic  partner,
SmithKline Beecham plc (SB). Selected research projects are continuing, directed
at developing new  applications  for the OraSure oral  collection  device with a
focus on tests  needed to expand the use of the  OraSure  device  with  existing
customers in life insurance and public health markets, and to move into the area
of drugs-of-abuse testing, a market the Company has not previously served.

Gross margins on product  sales were 56% and 57% of sales in the second  quarter
and first six months of fiscal  1998 as  compared to 61% and 60% of sales in the
comparable periods of fiscal 1997. The decline in gross margin for the first six
months was due to negative volume variances as production was decreased in order
to maintain  inventory levels. The Company expects that margins will increase in
the third quarter of fiscal 1998.

Research  and  development  costs  decreased  by  $455,000 or 42% in the current
quarter as compared to the second quarter of fiscal 1997, and by $569,000 or 30%
in the comparable  six-month  period.  This decrease was the result of continued
cost  containment  measures  and a  narrowing  of  the  focus  of  research  and
development  projects to those that were judged to be commercially viable in the
shortest timeframe.  Expenditures for these projects can vary significantly from
quarter to quarter as new  projects  are  started  while other  projects  may be
extended or completed.  Research and development for oral fluid testing products
for other diseases and drugs-of-abuse continued to expand during the quarter.

Selling,  general and  administrative  expenses decreased $306,000 or 18% in the
current  quarter as  compared  to the  second  quarter  of fiscal  1997,  and by
$466,000 or 15% in the comparable  six-month period,  primarily as a result of a
reduction in compensation expense and as a result of cost containment measures.

Year 2000  Compliance.  The Company has determined  that the costs of addressing
the Year 2000 issue are not material to the operations or financial condition of
the Company.


LIQUIDITY AND CAPITAL RESOURCES

<TABLE>
(In thousands)                                                                        3/31/98               9/30/97
<S>                                                                                   <C>                   <C>    
Cash and cash equivalents..............................................               $   579               $ 1,934
Marketable securities..................................................                 5,434                 7,142
Working capital........................................................                 6,617                 9,532
</TABLE>

During the current  quarter,  proceeds  from the sale of  marketable  securities
represented  the primary source of funds for meeting the Company's  requirements
for  operations and business  expansion.  Trade  accounts  receivable  increased
during the  quarter by $24,000 or 3%.  Other  receivables  decreased  during the
quarter by $934,000 or 88% as Agritope repaid  operating  expense  advances made
during the month of December as part of the spin-off agreement. The rate of cash
usage as  reflected  in the  reduction  of cash and cash  equivalents  decreased
significantly  from $1.2 million in the first  quarter to $144,000 in the second
quarter due to Agritope's  repayment of operating expense advances and continued
emphasis by management on cost containment.

                                       10
<PAGE>


PART II.  OTHER INFORMATION


ITEM 2.  CHANGES IN SECURITIES AND USE OF PROCEEDS

Vector  Securities  International,  Inc.  ("Vector  Securities"),  served as the
Company's financial advisor in connection with the spin-off of Agritope, Inc., a
previous proposal for issuance of targeted stock, and other matters.  In partial
consideration for Vector Securities' services,  the Company agreed and disclosed
at the time of the  Agritope  spin-off  that  Vector  Securities  would  receive
warrants to purchase an aggregate  of 416,667  shares of Epitope  common  stock,
$.01 par value per share ("Epitope  Stock"),  at a price equal to 110 percent of
the average closing price of Epitope stock for the five consecutive trading days
beginning on the ex dividend  date for the Agritope  spin-off.  Pursuant to this
agreement,  the Company issued to Vector Securities on May 5, 1998,  warrants to
purchase  416,667  shares of Epitope  Stock at a price of $5.913 per share.  The
warrants expire on December 30, 2000.

The warrants were issued without registration pursuant to the exemption provided
by Section 4(2) of the Securities  Act of 1933. In accordance  with the terms of
the warrants, the Company will register the shares issuable upon exercise of the
warrants at Vector Securities' request.


ITEM 4. SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS

At the 1998 annual meeting of  shareholders of the Company on February 17, 1998,
the following  individuals  were elected by the votes  indicated as directors of
the Company for terms expiring at the annual  meetings of  shareholders  for the
years shown:

<TABLE>
       NOMINEE             DIRECTOR CLASS          TERM EXPIRES              VOTES FOR              VOTES WITHHELD
<S>                             <C>                    <C>                  <C>                          <C>    
John W. Morgan                  1                      2000                 12,310,850                   119,127
Margaret H. Jordan              3                      2001                 12,314,078                   115,899
Michael J. Paxton               3                      2001                 12,313,750                   116,227
</TABLE>

The other  directors  whose terms of office  continued  after the annual meeting
are: W. Charles Armstrong, Andrew S. Goldstein, Roger L. Pringle, and G. Patrick
Sheaffer. In addition,  Robert J. Zollars was elected by the remaining directors
to fill a vacancy on the board  created by the  retirement  of R. Douglas  Norby
effective  following the annual  meeting.  Mr.  Zollar's term will expire at the
annual meeting of shareholders in 1999.


ITEM 5.  OTHER INFORMATION

MANAGEMENT CHANGES

As previously  announced,  several changes in the Company's  management occurred
following the spin-off of Agritope, Inc.

Charles E. Bergeron,  Vice President of Operations and Chief Financial Officer -
Epitope  Medical  Products,  became  Chief  Financial  Officer  of  the  Company
following the  retirement of Gilbert N. Miller in connection  with the spin-off.
Mr.  Bergeron joined the Company in August 1993 as President and Chief Executive
Officer of Agrimax Floral Products, Inc., then a wholly owned subsidiary.

J. Richard George, Ph.D., was named Chief Scientific Officer in January 1998 and
is now responsible for the Company's research and product development groups. He
joined the Company as Vice  President of  Scientific  Affairs - Epitope  Medical
Products in March 1995.

In  January  1998,  John H.  Fitchen,  M.D.,  Senior  Vice  President  and Chief
Operating Officer, left the Company to pursue other interests.

                                       11
<PAGE>


Edward V. Collom joined the Company on March 9, 1998, as Vice President of Sales
and Marketing.  Prior to accepting his position with the Company, Mr. Collom had
responsibility  for sales and  marketing of forensic  drug testing  services and
drugs-of-abuse and on-site drug screening  devices,  at Pharm Chem Laboratories,
Menlo Park, California.

As noted under Item 4, Robert J. Zollars was elected to the  Company's  board of
directors to fill a vacancy on the board created by the retirement of R. Douglas
Norby effective  following the annual meeting of  shareholders.  Mr. Zollars has
nearly 20 years of health care industry  experience with  organizations  such as
Cardinal Health, Inc., Baxter International,  Inc., and American Hospital Supply
Corp.

The Company's  Nominating Committee is in the process of selecting a replacement
for Richard K.  Donahue,  who retired from the board of directors as of February
17, 1998.

PRODUCT CLEARANCES

During the quarter, the Company announced regulatory clearances received for use
of its OraSure oral specimen collection device for various applications.

The  FDA  granted  clearance  for  use  of  OraSure  with  enzyme   immunoassays
manufactured by STC Technologies, Inc. to test for cocaine, methamphetamines and
cannabanoids  (marijuana) in January and February 1998.  Management  anticipates
approval  for use of the OraSure  device to test for  opiates and  phencyclidine
(PCP) in the months ahead.

The OraSure device has also been approved in Japan for cotinine  testing of life
insurance  applicants.  Cotinine  is a  derivative  of nicotine  that  indicates
whether the tested subject is a smoker.  The Finance Ministry of Japan announced
in February that life insurance companies could reduce premiums on new nonsmoker
policies by as much as thirty percent.


ITEM 6.  EXHIBITS AND REPORTS ON FORM 8-K

(a)      Exhibits

Exhibits are listed on the attached  exhibit index  following the signature page
of this report.

(b)      Reports on Form 8-K

None.

                                       12
<PAGE>


                                   SIGNATURES

Pursuant  to the  requirements  of the  Securities  Exchange  Act of  1934,  the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned thereunto duly authorized.



                                       EPITOPE, INC., an Oregon corporation

May 12, 1998                           /s/ CHARLES E. BERGERON
Date                                   Charles E. Bergeron
                                       Chief Financial Officer
                                       (Principal Financial Officer)





May -12, 1998                          /s/ THEODORE R. GWIN
Date                                   Theodore R. Gwin
                                       Controller
                                       (Principal Accounting Officer)


                                       13
<PAGE>


                                  EXHIBIT INDEX


4.    Warrant dated May 5, 1998, issued to Vector Securities International, Inc.


27.   Financial Data Schedule

                                       14


THIS WARRANT AND ANY SHARES  ACQUIRED UPON THE EXERCISE OF THIS WARRANT HAVE NOT
BEEN  REGISTERED  UNDER THE SECURITIES ACT OF 1933, AS AMENDED (the "1933 ACT"),
AND MAY NOT BE TRANSFERRED, SOLD OR OTHERWISE DISPOSED OF UNLESS THE TRANSACTION
IS REGISTERED  UNDER THE 1933 ACT AND APPLICABLE  STATE LAW OR AN EXEMPTION FROM
REGISTRATION REQUIREMENTS IS AVAILABLE.

                                  EPITOPE, INC.

               Warrant for the Purchase of Shares of Common Stock
               --------------------------------------------------

                                   May 5, 1998


No.   98-01                                                       416,667 Shares

FOR VALUE RECEIVED, EPITOPE, INC., an Oregon corporation (the "Company"), hereby
certifies  that VECTOR  SECURITIES  INTERNATIONAL,  INC.,  or permitted  assigns
thereof  ("Vector"),  is entitled to purchase  from the Company,  at any time or
from time to time prior to 5:00 p.m.,  New York City time,  on December 30, 2000
(the  "Expiration  Date"),  416,667 fully paid and  nonassessable  shares of the
common stock,  $.01 par value, of the Company,  including  associated  preferred
stock purchase  rights ("Common  Stock"),  upon payment of the purchase price of
$5.913 per share, subject to adjustment pursuant to the terms hereof.

Hereinafter  (i) the shares of Common Stock  purchasable  hereunder or under any
other Warrant (as hereinafter  defined) are referred to as the "Warrant Shares,"
(ii) the aggregate  purchase  price payable  hereunder for the Warrant Shares is
referred to as the "Aggregate  Warrant Price," (iii) the price payable hereunder
for each of the Warrant Shares is referred to as the "Per Share Warrant  Price,"
(iv) this Warrant and all warrants  hereafter issued in exchange or substitution
for this Warrant or such other  warrants are referred to as the  "Warrants"  and
(v) the holder of this Warrant is referred to as the "Holder" and the holders of
this Warrant and all other Warrants are referred to as the "Holders."


1.      Exercise of Warrant

        This Warrant may be exercised, in whole at any time or in part from time
to time,  prior to the  Expiration  Date by the Holder by the  surrender of this
Warrant  to the  Company  (with the  subscription  form at the end  hereof  duly
executed)  at the address set forth in Section 10 hereof,  together  with proper
payment of the Aggregate  Warrant Price,  or the  proportionate  part thereof if
this Warrant is exercised in part, and any applicable taxes. Payment for Warrant
Shares shall be made by cashier's check or by wire transfer of funds.

        If this Warrant is exercised in part, this Warrant must be exercised for
a number of whole  shares of Common  Stock not less than  1,000  shares  and the
Holder is  entitled  to receive a new Warrant  covering  the Warrant  Shares for
which this Warrant has not been exercised. Upon such


                                     - 1 -
<PAGE>


surrender of this Warrant,  the Company will (a) issue a certificate in the name
of the Holder for the  number of whole  shares of the Common  Stock to which the
Holder shall be entitled and, if this Warrant is exercised in whole,  in lieu of
any fractional  share of the Common Stock to which the Holder shall be entitled,
pay to the Holder cash in an amount  equal to the fair value of such  fractional
share  (determined  in such  reasonable  manner as the Board of Directors of the
Company shall  determine),  and (b) deliver the other  securities and properties
receivable upon the exercise of this Warrant,  or the proportionate part thereof
if this  Warrant  is  exercised  in part,  pursuant  to the  provisions  of this
Warrant.  The Company shall not be required to issue or deliver any  certificate
for shares of Common  Stock or other  securities  upon the  exercise of Warrants
evidenced by this Warrant until any applicable  transfer tax and any other taxes
or  governmental  charges  that the Company may be required by law to collect in
respect of such  exercise  shall have been paid,  such tax being  payable by the
Holder of this Warrant at the time of surrender for exercise.

        Each  exercise  of this  Warrant  shall be deemed to have been  effected
immediately  prior to the close of  business on the  business  day on which this
Warrant shall have been  surrendered  to the Company as provided in this Section
1,  and at such  time,  the  person  or  persons  in  whose  name or  names  any
certificate  or  certificates  for shares of Common Stock shall be issuable upon
such  exercise  shall be deemed to have  become  the holder or holders of record
thereof.

2.      Reservation of Warrant Shares; Listing; Preservation of Rights

(a)     The Company agrees that,  prior to the  expiration of this Warrant,  the
        Company will at all times (i) have  authorized and in reserve,  and will
        keep  available,  solely for  issuance or delivery  upon the exercise of
        this Warrant,  the shares of the Common Stock and other  securities  and
        properties as from time to time shall be receivable upon the exercise of
        this Warrant, free and clear of all restrictions on sale or transfer and
        free and clear of all preemptive or similar  contractual rights and (ii)
        use its best efforts to keep the Warrant Shares authorized for quotation
        on the National Market Tier of the Nasdaq Stock Market, or on such other
        national  securities  exchange or market upon which the Common  Stock is
        then listed.

(b)     The Company will not, by amendment of its articles of  incorporation  or
        through any consolidation,  merger, reorganization,  transfer of assets,
        dissolution,  issue or sale of securities or any other voluntary action,
        avoid or seek to avoid the observance or performance of any of the terms
        of this Warrant or the rights represented hereby.

3.      Protection Against Certain Dilution

(a)     In case the  Company  shall  hereafter  (i) declare a dividend or make a
        distribution  on its  capital  stock in  shares of  Common  Stock,  (ii)
        subdivide its  outstanding  shares of Common Stock into a greater number
        of shares,  (iii) combine its outstanding  shares of Common Stock into a
        smaller number of shares or (iv) issue by reclassification of its Common
        Stock any shares of capital stock of the Company,  the Per Share Warrant
        Price and the


                                     - 2 -
<PAGE>


        number and kind of shares of Common Stock  receivable  upon  exercise of
        this Warrant in effect at the time of the record date for such  dividend
        or  of  the  effective   date  of  such   subdivision,   combination  or
        reclassification shall be proportionately adjusted so that the Holder of
        any Warrant  upon the  exercise  hereof shall be entitled to receive the
        number and kind of shares of Common Stock or other  capital stock of the
        Company  which the Holder  would have  received  had it  exercised  such
        Warrant  immediately prior thereto.  An adjustment made pursuant to this
        Section 3(a) shall become effective immediately after the record date in
        the case of a  dividend  or  distribution  and  shall  become  effective
        immediately  after  the  effective  date in the  case of a  subdivision,
        combination or  reclassification.  If as a result of an adjustment  made
        pursuant to this  Section  3(a),  the Holder of any  Warrant  thereafter
        surrendered  for exercise shall become entitled to receive shares of two
        or more  classes  of capital  stock or shares of Common  Stock and other
        capital   stock  of  the  Company,   the  Board  of   Directors   (whose
        determination  shall be  conclusive  and shall be described in a written
        notice to the Holder of any  Warrant  promptly  after  such  adjustment)
        shall  determine the  allocation of the adjusted Per Share Warrant Price
        between or among  shares of such  classes of capital  stock or shares of
        Common Stock and other capital stock.

(b)     In case the Company after the date hereof (a) shall  consolidate with or
        merge into any other entity and shall not be the continuing or surviving
        corporation  of such  consolidation  or merger,  or (b) shall permit any
        other  entity to  consolidate  with or merge  into the  Company  and the
        Company shall be the  continuing or surviving  entity but, in connection
        with such  consolidation  or merger,  the Common  Stock shall be changed
        into or exchanged  for stock or other  securities of any other entity or
        cash or any other property,  or (c) shall transfer all or  substantially
        all of its properties or assets to any other entity, or (d) shall effect
        a capital  reorganization  or  reclassification  of the Common  Stock or
        other securities of the Company ((a) - (d) being  collectively  referred
        to as  "Transactions"),  the Holder of this Warrant shall have the right
        thereafter  to  exercise  such  Warrant  for  the  kind  and  amount  of
        securities,  cash or other property which the Holder would have received
        or have been entitled to receive  immediately after such Transaction had
        this Warrant been exercised  immediately  prior to the effective date of
        such  Transaction  and in  any  such  case,  if  necessary,  appropriate
        adjustment  shall be made in the application of the provisions set forth
        in this Section 3 with respect to the rights and interests thereafter of
        the Holder of this Warrant to the end that the  provisions  set forth in
        this Section 3 shall thereafter  correspondingly be made applicable,  as
        nearly as may be reasonable, in relation to any shares of stock or other
        securities or in relation to any shares of stock or other  securities or
        property  thereafter  deliverable  on the exercise of this Warrant.  The
        above   provisions  of  this  Section  3(b)  shall  similarly  apply  to
        successive  Transactions.  The  issuer  of any  shares of stock or other
        securities or property  thereafter  deliverable  on the exercise of this
        Warrant shall be responsible  for all of the agreements and  obligations
        of the Company hereunder.  Notice of any such Transaction shall be given
        to Holders not less than 30 days prior to said event; provided, however,
        that issuance of a press release shall constitute such notice.


                                     - 3 -
<PAGE>


(c)     Nothing  in this  Warrant  Agreement  shall be  interpreted  to  require
        adjustment  in the Per Share Warrant Price upon issuance of shares under
        or grant by the Company of options to employees  or directors  under any
        stock  option  plan  or  arrangement  of  the  Company  approved  by the
        shareholders  of the  Company,  or the issuance of any and all shares of
        Common  Stock upon  exercise  of such  options or upon the  issuance  of
        shares under any options, warrants, or convertible securities.

(d)     No adjustment  in the Per Share  Warrant Price shall be required  unless
        such adjustment  would require an increase or decrease of at least 1% of
        the then existing Per Share Warrant Price;  provided,  however, that any
        adjustments  which by reason of this Section 3(d) are not required to be
        made shall be carried  forward and taken into account in any  subsequent
        adjustment;   provided  further,  however,  that  adjustments  shall  be
        required and made in  accordance  with the  provisions of this Section 3
        (other  than  this  Section  3(d))  not  later  than such time as may be
        required in order to preserve the tax-free  nature of a distribution  to
        the  Holder of this  Warrant  or Common  Stock  issuable  upon  exercise
        hereof.  All  calculations  under  this  Section  3 shall be made to the
        nearest cent or to the nearest  share,  as the case may be.  Anything in
        this Section 3 to the  contrary  notwithstanding,  the Company  shall be
        entitled to make such  reductions  in the Per Share  Warrant  Price,  in
        addition to those  required by this  Section 3, as it in its  discretion
        shall deem to be advisable in order that any stock dividend, subdivision
        of shares or  distribution  of rights to  purchase  stock or  securities
        convertible or  exchangeable  for stock hereafter made by the Company to
        its shareholders shall not be taxable.

(e)     Whenever  the Per Share  Warrant  Price is  adjusted as provided in this
        Section  3 and upon  any  modification  of the  rights  of a  Holder  of
        Warrants in  accordance  with this Section 3, the Company  shall prepare
        and retain on file a statement setting forth the Per Share Warrant Price
        and the number of Warrant Shares after such  adjustment or the effect of
        such  modification,  a  brief  statement  of the  facts  requiring  such
        adjustment  or  modification  and the manner of  computing  the same and
        cause  a copy of such  statement  to be  mailed  to the  Holders  of the
        Warrants.

(f)     The Company will use  reasonable  efforts to notify the Holders at least
        twenty  (20) days prior to (i) any taking by the  Company of a record of
        the holders of any class of  securities  for the purpose of  determining
        the holders  thereof who are  entitled to receive any  dividend or other
        distribution  or any right to  subscribe  for or purchase  any shares of
        stock or any  other  securities  or (ii) any  voluntary  or  involuntary
        dissolution,  liquidation or winding-up of the Company.  Any such notice
        shall  include the date or expected  date on which any such record is to
        be taken for the purpose of such dividend,  distribution  or right,  and
        the amount and character of such dividend,  distribution  or right,  and
        the date or  expected  date on which  any  dissolution,  liquidation  or
        winding-up  is to take  place  and the  time,  if any such time is to be
        fixed,  as of which the  holders  of record  of  Common  Stock  shall be
        entitled to exchange  their shares of Common Stock for the securities or
        other  property  deliverable  upon  such  reorganization,   dissolution,
        liquidation or winding-up.


                                     - 4 -
<PAGE>


4.      Rights of Holder as Shareholder

        No holder of this Warrant shall,  as such, be entitled to vote,  receive
dividends,  or  otherwise  be deemed  the  holder  of Common  Stock or any other
securities  of the  Company  that may at any time be  issuable  on the  exercise
hereof  for any  purpose  whatsoever,  nor shall  anything  contained  herein be
construed to confer upon the holder of this Warrant,  as such, any of the rights
of a  shareholder  of the  Company  or any  right  to vote for the  election  of
directors or upon any matter submitted to shareholders at any meeting thereof or
to give or withhold  consent to any  corporate  action  (whether upon any matter
submitted  to  shareholders  at any  meeting  thereof or  otherwise)  including,
without   limitation,   giving   or   withholding   consent   to   any   merger,
recapitalization,  issuance  of stock,  reclassification  of stock,  exchange of
stock,  consolidation  or conveyance,  or to receive notice of meetings or other
actions affecting shareholders or to receive dividends or subscription rights or
other distributions.

5.      Fully Paid Stock

        The Company  will take all such  actions as may be  necessary  to assure
that the shares of the Common Stock  represented  by each and every  certificate
for Warrant Shares  delivered on the exercise of this Warrant shall, at the time
of  such  delivery,   be  validly  issued  and   outstanding,   fully  paid  and
nonassessable,  and not subject to preemptive  rights, and the Company will take
all such  actions  as may be  necessary  to assure  that the par value or stated
value,  if any,  per share of the Common  Stock is at all times equal to or less
than the then Per Share Warrant Price.

6.      Registration under Securities Act of 1933

(a)  Demand  Registration.  At any time prior to  December  30,  2002,  upon the
request of holders of Warrants or Warrant Shares  representing a majority of the
Warrant Shares  issuable upon exercise of this Warrant,  the Company agrees that
the Company  will on two  occasions  file,  under the 1933 Act,  as  amended,  a
registration  statement on Form S-3 or a successor  form covering  resale of the
Registrable  Securities  (as defined  below)  issuable upon the exercise of this
Warrant (the "Registration Statement"). The Company will use its best efforts to
cause  the  Registration  Statement  to  become  effective  as  of  the  soonest
practicable  date following the date of filing and the Company will (i) take all
other reasonable  action necessary under any federal law or regulation to permit
all Registrable Securities to be sold or otherwise disposed of, (ii) prepare and
file with the Securities and Exchange Commission such amendments and supplements
to the Registration Statement and the prospectus used in connection therewith as
may be necessary to keep the Registration  Statement effective until the earlier
to  occur  of (x) the  sale  of all of the  Registrable  Securities  purchasable
hereunder  and  (y) 12  consecutive  months  after  the  effective  date of such
registration   statement,   and  (iii)  maintain  compliance  with  the  federal
securities laws and  regulations.  For purposes of this Section 6,  "Registrable
Securities"  means (a) any Common Stock or other  securities  issued or issuable
upon  exercise of this Warrant and (b) any  securities  issued or issuable  with
respect to any  securities  referred to in the foregoing  clause by way of share
dividend  or  share  split  or in  connection  with  a  combination  of  shares,
recapitalization, merger, consolidation or other reorganization or otherwise. As
to any particular Registrable


                                     - 5 -
<PAGE>


Securities,   once  issued,  such  securities  shall  cease  to  be  Registrable
Securities  when (a) a  registration  statement with respect to the sale of such
securities  shall have become  effective  under the 1933 Act and such securities
shall have been disposed of in accordance with such registration statement,  (b)
they shall have been  distributed  to the  public  pursuant  to Rule 144 (or any
successor  provision)  under the 1933 Act,  or (c) they shall have  ceased to be
outstanding.

(b)     Furnishing  of  Prospectus.  The Company  shall,  upon the filing of the
        Registration  Statement  furnish  to  each  Holder  of  any  Registrable
        Securities  (and  to each  underwriter,  if  any,  of  such  Registrable
        Securities)  such  number  of  copies of  prospectuses  and  preliminary
        prospectuses  in conformity  with the  requirements  of the 1933 Act and
        such other documents as such Holder may reasonably  request, in order to
        facilitate  the public  sale or other  disposition  of all or any of the
        Registrable  Securities;  provided,  however, that the obligation of the
        Company to deliver copies of prospectuses or preliminary prospectuses to
        Holder  shall be subject to the  receipt  by the  Company of  reasonable
        assurances  from  the  Holder  that  the  Holder  will  comply  with the
        applicable  provisions  of the 1933 Act and of such other  securities or
        blue sky laws as may be applicable  in  connection  with any use of such
        prospectuses or preliminary prospectuses.

(c)     No Demand in Event of  Withdrawal  of  Notice.  No right of the  Holders
        under  Section  6(a)  shall be  deemed to have  been  exercised  if with
        respect  to such  right:  (i) the  requisite  notice  given  by  Holders
        pursuant to Section 6(a) is  withdrawn  prior to the date of filing of a
        registration  statement  or if a  registration  statement  filed  by the
        Company  under the 1933 Act pursuant to Section 6(a) is withdrawn  prior
        to its effective  date, in either case, by written notice to the Company
        from Holders to be included or which are  included in such  registration
        statement stating that such Holders have elected not to proceed with the
        offering  contemplated  by such  registration  statement  because  (x) a
        development in the Company's affairs has occurred or has become known to
        such Holders  subsequent to the date of the notice by the Holders to the
        Company  requesting  registration of the  Registrable  Securities or the
        filing of such  registration  statement  which,  in the judgment of such
        Holders or the managing  underwriter  of the proposed  public  offering,
        materially  and adversely  affects the market price of such  Registrable
        Securities or the distribution of such  Registrable  Securities or (y) a
        registration statement filed by the Company pursuant to Section 6(a), in
        the  reasonable  opinion of  counsel  for such  Holders or the  managing
        underwriter  of  the  proposed  public  offering,   contains  an  untrue
        statement of a material  fact or omits to state a material fact required
        to be stated  therein or  necessary to make the  statements  therein not
        misleading  in light of the  circumstances  under which made (other than
        any such  statement  or omission  relating to such  Holders and based on
        information  supplied or failed to be supplied by such  Holders) and the
        Company has not,  promptly after written notice thereof,  corrected such
        statement  or omission in an amendment  to such  registration  statement
        filed; or (ii) a registration  statement  pursuant to Section 6(a) shall
        have  become  effective  under  the 1933 Act and less  than  eighty-five
        percent (85%) of the Registrable  Securities included therein shall have
        been sold as a result of any stop  order,  injunction  or other order or
        requirement  of  the   Securities  and  Exchange   Commission  or  other
        governmental agency or court.


                                     - 6 -
<PAGE>


(d)     Expenses of Offering.  The Company  shall pay all  expenses  incurred in
        connection  with  any  registration  or  other  action  pursuant  to the
        provisions  of this  Section 6, other than  underwriting  discounts  and
        commissions,  any legal, accounting,  or consulting fees incurred by the
        Holders and taxes relating to the Registrable Securities.

(e)     No Exercise  Requirement.  Nothing  contained in this Agreement shall be
        construed as  requiring a Holder to exercise  its Warrants  prior to the
        initial  filing  of any  registration  statement  or  the  effectiveness
        thereof.

(f)     Notification  by Company.  The Company shall use  reasonable  efforts to
        notify each Holder of Registrable Securities covered by the Registration
        Statement, at any time when a prospectus relating thereto is required to
        be delivered  under the 1933 Act, upon the Company's  discovery that, or
        upon the  happening  of any event as a result of which,  the  prospectus
        included in such registration  statement, as then in effect, includes an
        untrue  statement of a material fact or omits to state any material fact
        required  to be  stated  therein  or  necessary  to make the  statements
        therein not  misleading  in the light of the  circumstances  under which
        they were made, and at the request of any such Holder  promptly  prepare
        and furnish to such Holder and each  underwriter,  if any, a  reasonable
        number of copies of a supplement  to or an amendment of such  prospectus
        as may be necessary so that, as thereafter  delivered to the  purchasers
        of  such  securities,  such  prospectus  shall  not  include  an  untrue
        statement of a material  fact or omit to state a material  fact required
        to be stated  therein or  necessary to make the  statements  therein not
        misleading in the light of the circumstances under which they were made.
        The Holders  shall not effect sales of Warrant  Shares after  receipt of
        such notice from the Company until an amendment becomes effective or the
        supplement has been filed. The Company's  obligations under this Section
        6(g) shall  expire at such time as the Company is no longer  required to
        maintain the effectiveness of the Registration Statement.

(g)     Compliance with SEC Rules and  Regulations.  The Company shall otherwise
        use its best efforts to comply with all applicable rules and regulations
        of the  Securities  and  Exchange  Commission  and will  furnish to each
        Holder of Registrable  Securities included in any registration statement
        at least five (5)  business  days prior to the filing  thereof a copy of
        any amendment or supplement to such registration statement or prospectus
        and shall not file any amendment or supplement thereof to which any such
        Holder shall have reasonably objected on the grounds that such amendment
        or  supplement  does  not  comply  in all  material  respects  with  the
        requirements of the 1933 Act or the rules or regulations thereunder.

(h)     Deferral Period.  If, because of a proposed material  acquisition or any
        other material event,  (i) the Company would, in the reasonable  opinion
        of its counsel,  be required to disclose material  information which, in
        the  good  faith  judgment  of the  Company,  would  not be in the  best
        interests of the Company and its  shareholders  to disclose at that time
        or


                                     - 7 -
<PAGE>


        the  filing  or  effectiveness  of  a  Registration  Statement  or  of a
        supplement  or  amendment to the  prospectus  pursuant to this Section 6
        would impede,  delay or interfere with any material financing,  offer or
        sale of  securities,  acquisition,  corporate  reorganization  or  other
        transaction  involving the Company or any affiliate of the Company,  the
        Company may defer such filing or effectiveness for a specified period of
        up to 90  days  after  such  filing  or  effectiveness  would  otherwise
        ordinarily have occurred. The Company may only request deferral pursuant
        to this section twice during any calendar year.

(i)     Holdback  Agreement.  The  Holder,  if  requested  by the Company and an
        underwriter  of the  Company's  securities,  shall  agree not to sell or
        otherwise  transfer  or dispose of any  Warrant or Warrant  Shares for a
        specified  period of time not to exceed 90 days  after any  underwritten
        registration  statement  pursuant to which the Company  proposes to sell
        its securities to the public generally has become  effective;  provided,
        however,  that all executive officers and directors of the Company enter
        into  similar  agreements.  In the event the Company  should make such a
        request, the 12-month period mentioned in Section 6(a) shall be extended
        by a number of days equal to the actual duration of the holdback period.

7.      Indemnification.

(a)     Indemnification  by the Company.  The Company  shall  indemnify and hold
        harmless  each Holder,  each of its officers  and  directors,  its legal
        counsel,  and each person,  if any,  who controls the Holder  within the
        meaning of the 1933 Act against any losses, claims, damages, liabilities
        (joint or several),  or expenses to which they may become  subject under
        the 1933 Act, the Securities Exchange Act of 1934, as amended (the "1934
        Act"),  or other federal or state law,  insofar as such losses,  claims,
        damages,  expenses, or liabilities (or actions in respect thereof) arise
        out of or are based upon any of the following  statements,  omissions or
        violations (a "Violation"):

        (i)    any untrue  statement or alleged  untrue  statement of a material
               fact  contained  in the  Registration  Statement,  including  any
               preliminary  prospectus or final prospectus  contained therein or
               any amendments or supplements thereto,

        (ii)   the omission or alleged omission to state therein a material fact
               required to be stated therein or necessary to make the statements
               therein not misleading, or

        (iii)  any  violation  or alleged  violation  by the Company of the 1933
               Act,  the 1934 Act,  any  state  securities  law,  or any rule or
               regulation  promulgated  under the 1933 Act, the 1934 Act, or any
               state securities law.

        The Company shall  reimburse  each Holder and its  officers,  directors,
        legal  counsel or  controlling  persons for any legal or other  expenses
        reasonably   incurred  by  them  in  connection  with  investigating  or
        defending any such loss, claim, damage, liability, or


                                     - 8 -
<PAGE>


        action.  This  indemnity  agreement  shall not apply to amounts  paid in
        settlement  of any loss,  claim,  damage,  liability,  or action if such
        settlement is effected without the consent of the Company (which consent
        shall not be unreasonably withheld),  nor shall the Company be liable to
        the Holder in any case for any loss, claim, damage, liability, or action
        (A) to the extent  that it arises  out of or is based  upon a  Violation
        which occurs in reliance upon and in conformity with written information
        furnished  expressly for use in connection with such  registration by or
        on behalf of the Holder or such controlling person or (B) in the case of
        a sale directly by the Holder  (including a sale of such Warrant  Shares
        through any underwriter retained by the Holder or Holders to engage in a
        distribution  solely on behalf of the  Holder or the  Holders),  if such
        untrue  statement  or alleged  untrue  statement  or omission or alleged
        omission was  contained in a preliminary  prospectus  and corrected in a
        final or amended prospectus,  and the Holder failed to deliver a copy of
        the final or amended  prospectus at or prior to the  confirmation of the
        sale of the Warrant Shares to the person asserting any such loss, claim,
        damage or liability  in any case where such  delivery is required by the
        1933 Act.

(b)     Indemnification  by  Holders  of  Warrant  Shares.   Each  Holder  shall
        severally but not jointly indemnify and hold harmless the Company,  each
        of its officers and directors,  its legal counsel,  and each person,  if
        any,  who  controls  the  Company  within  the  meaning of the 1933 Act,
        against any losses, claims, damages,  liabilities (joint or several), or
        expenses  to which the  Company  or any such  director,  officer,  legal
        counsel,  or controlling person may become subject,  under the 1933 Act,
        the 1934 Act,  or other  federal or state law,  insofar as such  losses,
        claims, damages or liabilities (or actions in respect thereto) arise out
        of or are based upon any Violation, in each case to the extent (and only
        to the  extent)  that  such  Violation  occurs in  reliance  upon and in
        conformity  with written  information  furnished by or on behalf of such
        Holder expressly for use in connection with such registration;  and such
        Holder shall reimburse any legal or other expenses  reasonably  incurred
        by  the  Company  or any  such  director,  officer,  legal  counsel,  or
        controlling  person in connection  with  investigating  or defending any
        such loss, claim, damage, liability, or action; provided,  however, that
        the indemnity  agreement  contained in this Section 7 shall not apply to
        amounts paid in settlement of any such loss, claim,  damage,  liability,
        or action if such  settlement  is  effected  without the consent of such
        Holder, which consent shall not be unreasonably  withheld; and provided,
        further,  that the  indemnification  obligation  of such Holder shall be
        limited to the aggregate  public  offering  price of the Warrant  Shares
        sold by such Holder pursuant to such registration.

(c)     Notice,  Defense and Counsel.  Promptly  after receipt by an indemnified
        party under this Section 7 of notice of the  commencement  of any action
        (including any governmental  action), such indemnified party shall, if a
        claim in respect  thereof is to be made against any  indemnifying  party
        under this Section 7, deliver to the indemnifying party a written notice
        of the commencement  thereof and the  indemnifying  party shall have the
        right to participate  in, and, to the extent the  indemnifying  party so
        desires to assume and control the defense thereof with counsel  mutually
        satisfactory  to the parties;  provided,  however,  that an  indemnified
        party shall have the right to retain its own counsel, with the fees and


                                     - 9 -
<PAGE>


        expenses to be paid by the indemnifying party, if representation of such
        indemnified  party by the  counsel  retained by the  indemnifying  party
        would be inappropriate  due to actual or potential  differing  interests
        between such indemnified  party and any other party  represented by such
        counsel in such proceeding. The failure to deliver written notice to the
        indemnifying  party within a reasonable time of the  commencement of any
        such action, if prejudicial to its ability to defend such action,  shall
        relieve such  indemnifying  party of any  liability  to the  indemnified
        party  under  this  Section 7 to the extent of such  prejudice,  but the
        omission so to deliver  written notice to the  indemnifying  party shall
        not  relieve  it of any  liability  that it may have to any  indemnified
        party otherwise than under this Section 7.

8.      Loss etc. of Warrant

        Upon receipt of evidence satisfactory to the Company of the loss, theft,
destruction  or  mutilation  of  this  Warrant,   and  of  indemnity  reasonably
satisfactory to the Company,  if lost,  stolen or destroyed,  and upon surrender
and  cancellation of this Warrant,  if mutilated,  the Company shall execute and
deliver to the Holder a new Warrant of like date, tenor and denomination.

9.      Amendment

        These  Warrants may be amended only by written  mutual  agreement of the
Company and the Holders of a majority of the then outstanding Warrants.

10.     Communication

        No notice or other  communication  under this Warrant shall be effective
unless,  but any notice or other  communication  shall be effective and shall be
deemed  to  have  been  given  if,  the  same is in  writing  and is  mailed  by
first-class mail, postage prepaid, addressed as set forth below:

               If to the Company:    Epitope, Inc
                                     8505 S.W. Creekside Place
                                     Beaverton, Oregon 97008
                                     Attention:     Charles E. Bergeron
                                                    Chief Financial Officer

or such other address as the Company has designated in writing to the Holder.

               If to the Holder:     Vector Securities International,  Inc.
                                     1751 Lake Cook Road
                                     Deerfield, Illinois  60013
                                     Attention: Chairman and
                                                Chief Executive Officer

or such other address as the Holder has designated in writing to the Company.


                                     - 10 -
<PAGE>


11.     Headings

        The  headings  of  this  Warrant  have  been  inserted  as a  matter  of
convenience and shall not affect the construction hereof.

12.     Applicable Law

        This Warrant shall be governed by and  construed in accordance  with the
laws of the State of Oregon without giving effect to the principles of conflicts
of laws thereof.


13.     Assignment

        The Holder may assign or  transfer  this  Warrant in whole or in part by
completing and delivering to the Company the applicable  document of assignment,
duly  executed,  in the  form  attached  hereto.  Upon any  such  assignment  or
transfer,  the term  "Holder"  shall be deemed to include  any such  assignee or
transferee of the original Holder.

14.     Severability

        If one or more  provisions  of this  Warrant are held to be  enforceable
under applicable law, such provision shall be excluded from this Warrant and the
balance  of the  warrant  shall be  interpreted  as if such  provisions  were so
excluded and the balance shall be enforceable in accordance with its terms.

        IN WITNESS WHEREOF,  Epitope,  Inc. has caused this Warrant to be signed
by its Chief Financial Officer on the date stated above.


                                       /s/ Charles E. Bergeron
                                       Name: Charles E. Bergeron
                                       Title:   Chief Financial Officer
ATTEST:


/s/ J. Richard George
J. Richard George, Chief Scientific Officer



                                     - 11 -
<PAGE>


                                  SUBSCRIPTION
                                  ------------


The  undersigned,  --------------------,  pursuant  to  the  provisions  of  the
foregoing  Warrant,  hereby agrees to subscribe for and purchase ----- shares of
the Common Stock of Epitope,  Inc.  covered by said  Warrant,  and makes payment
therefor at the price per share provided by said Warrant.


Dated: ------------------------        Signature:  -----------------------------

                                       Address:    -----------------------------

                                                   -----------------------------


<PAGE>


                                   ASSIGNMENT
                                   ----------


FOR VALUE RECEIVED -------------------- hereby sells, assigns and transfers unto
- -------------------- the foregoing Warrant and all rights evidenced thereby, and
does  irrevocably  constitute  and  appoint  -------------------,  attorney,  to
transfer said Warrant on the books of Epitope, Inc.


Dated: ------------------------        Signature:  -----------------------------

                                       Address:    -----------------------------

                                                   -----------------------------


<PAGE>


                               PARTIAL ASSIGNMENT
                               ------------------


FOR VALUE  RECEIVED  --------------------  hereby  assigns  and  transfers  unto
- --------------------  the right to purchase  ----- shares of the Common Stock of
Epitope,  Inc. by the foregoing Warrant and a proportionate part of said Warrant
and the rights evidenced  hereby,  and does  irrevocably  constitute and appoint
- ----------------,  attorney,  to transfer that part of said Warrant on the books
of Epitope, Inc.


Dated: ------------------------        Signature:  -----------------------------

                                       Address:    -----------------------------

                                                   -----------------------------

<TABLE> <S> <C>


<ARTICLE>                     5
<LEGEND>
This  schedule  contains  summary  financial   information  extracted  from  the
condensed  consolidated financial statements included herein and is qualified in
its entirety by reference to such financial statements.
</LEGEND>
<MULTIPLIER>                    1
       
<S>                             <C>
<PERIOD-TYPE>                   6-MOS
<FISCAL-YEAR-END>               SEP-30-1998
<PERIOD-START>                  OCT-01-1997
<PERIOD-END>                    MAR-31-1998
<CASH>                               579,303
<SECURITIES>                       5,433,811
<RECEIVABLES>                        997,102
<ALLOWANCES>                          41,682
<INVENTORY>                        1,184,451
<CURRENT-ASSETS>                   8,569,952
<PP&E>                             5,221,068
<DEPRECIATION>                     4,272,418
<TOTAL-ASSETS>                    10,140,190
<CURRENT-LIABILITIES>              1,953,002
<BONDS>                                    0
                      0
                                0
<COMMON>                         110,993,976
<OTHER-SE>                      (102,806,788)
<TOTAL-LIABILITY-AND-EQUITY>      10,140,190
<SALES>                            3,394,347
<TOTAL-REVENUES>                   3,705,728
<CGS>                              1,586,254
<TOTAL-COSTS>                      5,754,189
<OTHER-EXPENSES>                    (179,223)
<LOSS-PROVISION>                           0
<INTEREST-EXPENSE>                         0
<INCOME-PRETAX>                   (1,689,238)
<INCOME-TAX>                               0
<INCOME-CONTINUING>                        0
<DISCONTINUED>                             0
<EXTRAORDINARY>                            0
<CHANGES>                                  0
<NET-INCOME>                      (1,689,238)
<EPS-PRIMARY>                           (.13)
<EPS-DILUTED>                              0
        


</TABLE>


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