EPITOPE INC/OR/
DEF 14A, 1998-01-16
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                           SCHEDULE 14A INFORMATION
Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934
(Amendment No.  )

Filed by the Registrant [x]
Filed by a Party other than the Registrant [ ]
Check the appropriate box:
[ ] Preliminary Proxy Statement          [ ] Confidential, for Use of 
[x] Definitive Proxy Statement                 the Commission Only (as
[ ] Definitive Additional Materials            permitted by 
[ ] Soliciting Material Pursuant to            Rule 14a-6(e)(2))
            Rule 14a-11(c) 
            or Rule 14a-12

                                  Epitope, Inc.
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified In Its Charter)

- --------------------------------------------------------------------------------
    (Name of  Person(s)  Filing Proxy  Statement  if other than the  Registrant)
Payment of Filing Fee (Check the appropriate box):
[x] No fee required.
[ ] Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.

    1)  Title of each class of securities to which transaction applies:

- --------------------------------------------------------------------------------
    2)  Aggregate number of securities to which transaction applies:

- --------------------------------------------------------------------------------
    3)  Per unit  price  or  other  underlying  value  of  transaction  computed
    pursuant to Exchange Act Rule 0-11 (set forth the amount on which the filing
    fee is calculated and state how it was determined):

- --------------------------------------------------------------------------------
    4)  Proposed maximum aggregate value of transaction:
    
- --------------------------------------------------------------------------------
    5)  Total fee paid:
    
- --------------------------------------------------------------------------------

[ ] Fee paid previously with preliminary materials.

[ ] Check box if any part of the fee is offset as provided by Exchange  Act Rule
0-11(a)(2)  and  identify  the  filing  for  which the  offsetting  fee was paid
previously.  Identify the previous filing by registration  statement  number, or
the form or schedule and the date of its filing.

<PAGE>

    1)  Amount Previously Paid:
    
- --------------------------------------------------------------------------------
    2)  Form, Schedule or Registration Statement No.:
    
- --------------------------------------------------------------------------------
    3)  Filing Party:
    
- --------------------------------------------------------------------------------
    4)  Date Filed:
    
- --------------------------------------------------------------------------------
<PAGE>
[Epitope logo]



                                  EPITOPE, INC.
                            8505 S.W. Creekside Place
                             Beaverton, Oregon 97008


                                                                January 16, 1998

Dear Shareholder:

         You are  cordially  invited  to  attend  the  1998  Annual  Meeting  of
Shareholders to be held on TUESDAY,  FEBRUARY 17, 1998, at the Oregon Convention
Center,  777 N.E. Martin Luther King Jr.  Boulevard,  Portland,  Oregon, at 9:00
a.m. Your Board of Directors and management look forward to personally  greeting
those present.  At the meeting,  you will be asked to elect one Class I director
and two Class III directors to serve on the Board of Directors  until the Annual
Meeting of Shareholders in the years 2000 and 2001 respectively; and to transact
such other business as may properly come before the meeting, or any adjournments
thereof.
         Your Board of Directors has approved the nominees for director named in
the enclosed Proxy  Statement and recommends that you vote FOR their election to
the Board of Directors.
         Your vote is very  important,  regardless  of the  number of shares you
own. Whether or not you plan to attend the Annual Meeting in person, we urge you
to  mark,  sign,  date,  and  mail  the  enclosed  proxy  card  promptly  in the
accompanying  postage prepaid  envelope.  You may, of course,  attend the Annual
Meeting and vote in person even if you have previously mailed your proxy card.

Sincerely yours,



John W. Morgan
President and Chief Executive Officer


<PAGE>



                                  EPITOPE, INC.
                            8505 S.W. Creekside Place
                             Beaverton, Oregon 97008
                                 ---------------

                    NOTICE OF ANNUAL MEETING OF SHAREHOLDERS
                          TO BE HELD FEBRUARY 17, 1998
                                 --------------


To the Shareholders of Epitope, Inc.:

         The  Annual  Meeting  of  Shareholders  of  Epitope,  Inc.,  an  Oregon
corporation (the "Company"),  will be held at the Oregon Convention  Center, 777
N.E.  Martin Luther King Jr.  Boulevard,  Portland,  Oregon  97232,  on TUESDAY,
FEBRUARY 17, 1998,  at 9:00 a.m. to elect one Class I director and two Class III
directors,  and to consider such other  business as may properly come before the
meeting or any  adjournments  thereof.  The foregoing items of business are more
fully described in the proxy statement accompanying this Notice.

         Only  holders  of Common  Stock of record at the close of  business  on
December  22,  1997,  will  be  entitled  to  vote  at  the  Annual  Meeting  of
Shareholders and any adjournments thereof.

By Order of the Board of Directors


Andrew S. Goldstein
Secretary


January 16, 1998
Beaverton, Oregon











- --------------------------------------------------------------------------------
YOUR VOTE IS IMPORTANT.  WHETHER OR NOT YOU PLAN TO ATTEND THE MEETING,  YOU ARE
URGED TO MARK,  SIGN,  DATE,  AND  RETURN THE  ENCLOSED  PROXY  PROMPTLY  IN THE
ENVELOPE  PROVIDED.  RETURNING  YOUR PROXY DOES NOT DEPRIVE YOU OF YOUR RIGHT TO
ATTEND THE MEETING AND TO VOTE YOUR SHARES IN PERSON.
- --------------------------------------------------------------------------------




<PAGE>



                                  EPITOPE, INC.
                            8505 S.W. Creekside Place
                             Beaverton, Oregon 97008


                                   -----------



                                 PROXY STATEMENT

         This proxy  statement is being mailed on or about  January 16, 1998, to
shareholders  of  Epitope,  Inc.,  an Oregon  corporation  (the  "Company"),  in
connection with the solicitation of proxies in the accompanying form ("Proxies")
by the Board of  Directors  of the Company  (the  "Board") for use at the Annual
Meeting of  Shareholders  to be held on February 17, 1998,  at 9:00 a.m., at the
Oregon Convention Center,  777 N.E. Martin Luther King Jr. Boulevard,  Portland,
Oregon 97232, and at any adjournments  thereof (the "Annual Meeting"),  pursuant
to the accompanying Notice of Annual Meeting of Shareholders.


                                     PROXIES

         Shares  represented  by a  properly  executed  Proxy  will be  voted in
accordance  with the  shareholder's  instructions  indicated on the Proxy. If no
instructions are given, the shareholder's  shares will be voted according to the
recommendations of the Board as stated on the Proxy. Shareholders may revoke the
authority  granted  by their  Proxies at any time  before the Annual  Meeting by
notice in writing  delivered to the  Secretary of the Company,  by  submitting a
subsequently  dated proxy, or by attending the Annual  Meeting,  withdrawing the
Proxy, and voting in person.

         At the Annual Meeting, action will be taken on the matters set forth in
the accompanying  Notice of Annual Meeting of Shareholders and described in this
proxy statement.  The Board knows of no other matters to be presented for action
at the Annual  Meeting.  If any other matters do properly come before the Annual
Meeting,  the persons  named on the Proxy will have  discretionary  authority to
vote thereon in accordance with their best judgment.

         The  cost of  soliciting  Proxies  will be  borne  by the  Company.  In
addition to solicitations by mail, certain of the Company's directors, officers,
and regular employees may solicit Proxies personally or by telephone, telegraph,
or other means without  additional  compensation.  The Company has retained D.F.
King & Co., Inc., to assist in such  solicitation for an estimated fee of $2,500
plus reimbursement for certain expenses.

         Arrangements   will  also  be  made  with  brokerage  firms  and  other
custodians,  nominees,  and fiduciaries to forward solicitation  material to the
beneficial owners of stock held of record by such persons, and the Company will,
upon request, reimburse them for their reasonable expense in so doing.


   PLEASE MARK, SIGN, AND DATE THE ENCLOSED PROXY CARD, AND RETURN IT PROMPTLY
               IN THE ENCLOSED ENVELOPE PROVIDED FOR THIS PURPOSE.


                                                                               1
<PAGE>


                                VOTING SECURITIES

         On December  22,  1997,  the record date for  determining  shareholders
entitled to vote at the Annual Meeting, the Company had outstanding and entitled
to vote at the  meeting  13,454,330  shares of Common  Stock,  no par value (the
"Common  Stock").  Each  share of Common  Stock is  entitled  to one vote on any
matter  brought  before the  meeting.  A majority of the shares of Common  Stock
outstanding  as of the  record  date,  represented  in person or by proxy at the
meeting, will constitute a quorum for the transaction of business.

                             PRINCIPAL SHAREHOLDERS

         The  following  table sets forth  information  as of December 30, 1997,
regarding the  beneficial  ownership of the  Company's  Common Stock by (a) each
person  who is known to the  Company to be the  beneficial  owner of more than 5
percent of the Common  Stock  outstanding,  (b) each  director  and  nominee for
election as director,  (c) each of the Company's executive officers named in the
Summary Compensation Table under EXECUTIVE  COMPENSATION,  and (d) all directors
and executive officers of the Company at January 16, 1998, as a group.

<TABLE>
                                                                       Amount and Nature of                Percent
Beneficial Owner                                                       Beneficial Ownership (1) (2)        of Class
- -------------------------------------------------------------------------------------------------------------------
<S>                                                                         <C>                             <C>
W. Charles Armstrong                                                         84,540(3)                          *

Joseph A. Bouckaert                                                          25,443                             *

Richard K. Donahue                                                           21,650(3)                          *

Adolph J. Ferro, Ph.D.                                                      558,312                          4.0%

John H. Fitchen, M.D.                                                       194,406(3)                       1.4%

Andrew S. Goldstein                                                         450,338                          3.3%

Margaret H. Jordan                                                           31,000                             *

Gilbert N. Miller                                                           211,934                          1.6%

John W. Morgan                                                                5,000(4)                          *

R. Douglas Norby                                                             68,750                             *

Michael J. Paxton                                                            52,052                             *

Roger L. Pringle                                                            136,177(3)                       1.0%

G. Patrick Sheaffer                                                          90,000                             *

All directors and executive officers as a group (11 persons)              1,111,168(3)                       7.8%
</TABLE>
- ---------
*Less than 1%

(1)      Subject  to  community  property  laws  where  applicable,   beneficial
         ownership  consists  of sole  voting  and  investment  power  except as
         otherwise indicated.

(2)      Includes  shares  subject  to  options  exercisable  within  60 days of
         December  30, 1997,  as follows:  Mr.  Armstrong,  80,000  shares;  Mr.
         Bouckaert, 25,000 shares; Mr. Donahue, 10,000 shares; Dr. Ferro,


2
<PAGE>


         556,204 shares;  Dr. Fitchen,  188,800 shares;  Mr. Goldstein,  194,000
         shares;  Ms. Jordan,  30,000 shares;  Mr. Miller,  209,104 shares;  Mr.
         Norby, 65,000 shares; Mr. Paxton,  50,552 shares; Mr. Pringle,  110,552
         shares;  Mr. Sheaffer,  77,500 shares;  and all directors and executive
         officers as a group, 786,604 shares.

(3)      Includes  shares as to which  the  individual  has  shared  voting  and
         dispositive power as follows:  Mr. Armstrong,  165 shares; Mr. Donahue,
         1,000 shares; Dr. Fitchen,  100 shares; Mr. Pringle,  1,500 shares; and
         all directors and executive officers as a group, 2,665 shares.

(4)      Does not include  27,752  shares of Common  Stock held in the  Epitope,
         Inc.  40l(k) Profit Sharing Plan (the "401(k)  Plan"),  as to which Mr.
         Morgan shares voting power as a trustee of the 401(k) Plan.  Mr. Morgan
         disclaims any economic beneficial interest in such shares.


             SECTION 16(A) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

         Section  16(a) of the  Securities  Exchange  Act of 1934  requires  the
Company's officers and directors and persons who own more than 10 percent of the
Common Stock  (collectively,  "Reporting  Persons") to file reports of ownership
and changes in  ownership  with the  Securities  and  Exchange  Commission  (the
"Commission"). Reporting persons are required by the Commission's regulations to
furnish the Company with copies of all Section 16(a) forms they file.

         Based  solely on its  review of the  copies of such  forms and  written
representations  regarding  the absence of a filing  requirement  received  from
Reporting  Persons,  the Company  believes  that with respect to the 1997 fiscal
year, all Reporting Persons complied with all applicable filing requirements.

                              ELECTION OF DIRECTORS

         At the Annual  Meeting,  shareholders  will vote on the election of one
Class I director and two Class III directors.  The  Nominating  Committee of the
Board of Directors has nominated John W. Morgan,  President and Chief  Executive
Officer,  for election as a Class I director,  for a term expiring at the Annual
Meeting of  Shareholders  in 2000,  and Margaret H. Jordan and Michael J. Paxton
for election as Class III directors, for terms expiring at the Annual Meeting of
Shareholders  in 2001.  The nominees for  election as  directors  are  presently
members of the Board.

         In the absence of instructions to the contrary,  shares of Common Stock
represented by properly  executed  Proxies will be voted for the three nominees,
each of whom has  consented to be named and to serve if elected.  If a quorum is
present,  each  nominee will be elected if he or she receives a plurality of the
votes cast by shares entitled to vote at the Annual Meeting.

         The Company does not know of anything  that would  preclude any nominee
from  serving.  However,  should any  nominee  for any reason  become  unable or
unwilling to serve as a director,  the persons named on the enclosed  Proxy will
vote the shares  represented  by each Proxy for such  substitute  nominee as the
Board may approve.

         Any vacancy that occurs  during the term of a director may be filled by
the affirmative  vote of a majority of the remaining  directors even though less
than a quorum of the Board.  The  vacancy  may be filled  until the next  annual
meeting of shareholders. Mr. Morgan was elected to the Board to fill the vacancy
that occurred upon the resignation of Adolph J. Ferro, Ph.D., in connection with
the spin-off of Agritope,  Inc. ("Agritope").  Accordingly,  Mr. Morgan has been
nominated  for  re-election  as a Class I  director  at the Annual  Meeting.  R.
Douglas Norby, currently a Class II director, and Richard K. Donahue,  currently
a Class III director, have submitted their resignations as directors,  effective
on the date of the Annual Meeting. The Nominating Committee of the Board has not
yet  identified  candidates to replace Mr.  Donahue and Mr. Norby.  Accordingly,
only two  candidates  for Class III directors  have been nominated for election.
Proxies  cannot be voted for more than two  Class III  directors  at the  Annual
Meeting.  The Board  expects to elect  directors to succeed Mr.  Donahue and Mr.
Norby at some time


                                                                               3
<PAGE>


following the Annual  Meeting.  The Company  expects that Mr.  Donahue's and Mr.
Norby's  successors  will be nominated for  re-election at the Annual Meeting of
Shareholders in 1999.

         Certain  information with respect to each person nominated for election
as a director and each person whose term of office as a director  will  continue
after the Annual Meeting is set forth below.

<TABLE>
                                                                                                           Director
Name                                        Principal Occupation                         Age                Since
- -------------------------------------------------------------------------------------------------------------------

Class I (Nominee and Directors Whose Terms of Office Expire in 2000):

<S>                                         <C>                                          <C>                 <C> 
W. Charles Armstrong                        Private Investor                             53                  1989

John W. Morgan                              President and Chief Executive                38                  1998
                                            Officer of the Company

Roger L. Pringle                            President of The Pringle Company,            57                  1989
                                            a management consulting firm,
                                            Portland, Oregon

Class II  (Directors Whose Terms of Office Expire in 1999):

Andrew S. Goldstein                         Senior Vice President of Advanced            49                  1981
                                            Technology Development -
                                            Epitope Medical Products

G. Patrick Sheaffer                         Chairman, President and Chief                58                  1983
                                            Executive Officer of Riverview
                                            Savings Bank, Camas, Washington

Class III (Nominees for Terms of Office to Expire in 2001):

Margaret H. Jordan                          President of The Margaret Jordan             55                  1995
                                            Group L.L.C., a management consulting
                                            firm for the health care organization
                                            industry, Addison, Texas


Michael J. Paxton                           Chairman, President and Chief                51                  1995
                                            Executive Officer of
                                            O'Cedar Holdings, Inc., a manufacturer
                                            of household cleaning products,
                                            Springfield, Ohio
</TABLE>


         W.  Charles  Armstrong,  now a  private  investor,  served  as  interim
President  and Chief  Executive  Officer of the Company from May 1997 to October
1997. He was Chairman and Chief Executive Officer of Bank of America Oregon from
September  1992 until  September  1996.  From April to  September  1992,  he was
Chairman and Chief  Executive  Officer of Bank of America Idaho.  Mr.  Armstrong
served as President and Chief Operating Officer of Honolulu Federal Savings Bank
from February 1989 to April 1992.  Prior to February  1989, he was President and
Chief  Executive  Officer of West One Bank,  Oregon.  He is also a  director  of
Agritope.

         Andrew S.  Goldstein  is a Senior  Vice  President  of the  Company,  a
position  he has held  since June  1990.  Prior to that  time,  he had been Vice
President of Product Development from December 1988, Vice President of


4
<PAGE>


Scientific  Affairs  from July 1987 to  December  1988,  and Vice  President  of
Research  and  Development  from 1981  until  July  1987.  He also has served as
Secretary  from  December  1988 to February  1993 and from  November 1995 to the
present and served as Treasurer  until March 1991.  Mr.  Goldstein  was Research
Associate  and  supervisor  of the  Histocompatibility  Laboratory at the Oregon
Health Sciences University  ("OHSU"),  where he was engaged in paternity testing
and transplantation immunology, from 1974 to 1981. Mr. Goldstein received a B.S.
degree in  microbiology  from Cornell  University  in 1969 and a M.S.  degree in
cytology from Fordham University in 1973.

         Margaret H. Jordan has been  President  of The Margaret  Jordan  Group,
L.L.C.,  since  October  1997.  Prior to that time,  she was President and Chief
Executive  Officer of Dallas Medical Resource ("DMR") from February 1996. DMR is
a  not-for-profit  alliance  of Dallas'  major  medical  organizations  that was
created to make Dallas, Texas, a regional, national and international center for
medical  referrals.  Ms.  Jordan was Vice  President  of Health  Care & Employee
Services at Southern  California  Edison Co. from  December  1992 until  January
1996.  She had previously  been a Vice  President and Regional  Manager with the
Kaiser  Foundation  Health Plan of Texas,  Inc.,  beginning in 1986,  and was an
Associate  Regional Manager of Kaiser Foundation  Health Plan of Georgia,  Inc.,
from 1984 to 1986. Ms. Jordan  received a B.S. degree in Nursing from Georgetown
University in 1964 and an M.S.  degree in Public  Health from the  University of
California,  Berkeley  in 1972.  She also  serves on the Board of  Directors  of
Eckerd Corporation.

         John W. Morgan has been  President and Chief  Executive  Officer of the
Company   since   October   1997.   Before   joining   the   Company,   he   was
President-Americas  of Regent Medical  Products Group,  Norcross,  Georgia since
1996. Prior to joining Regent,  he held various positions with Baxter Healthcare
Corporation,  where he worked for 13 years. From 1993 to 1996, he was President,
Mid-America  Regional  Company of Baxter.  Mr. Morgan  received a B.S. degree in
Public  Administration and Economics from the University of Arizona in 1982. Mr.
Morgan  also  serves  on  the  board  of  directors  of  Koch  Supply,  Inc.,  a
manufacturer and distributor for the red meat and poultry industry.

         Michael  J.  Paxton  became  Chairman,  President  and Chief  Executive
Officer of  O'Cedar  Holdings,  Inc.,  in  January  1996.  From March 1992 until
joining O'Cedar Holdings,  Inc., he was President and Chief Executive Officer of
The Haagen-Dazs Company,  Inc. Prior to that he was President of the Baked Goods
Division of The Pillsbury  Company.  Both  companies are  subsidiaries  of Grand
Metropolitan  PLC. He is also a director of  Transport  Corporation  of America,
Inc.

         Roger L.  Pringle has been  Chairman of the Board of the Company  since
April 1990. He is President of The Pringle Company, a management consulting firm
in Portland,  Oregon,  which he founded in 1975. Mr. Pringle has been a director
of Agritope since 1990 and is also a director of Bank of the Northwest.

         G.  Patrick  Sheaffer has been  President of Riverview  Savings Bank in
Camas,  Washington,  since 1979,  and has served as a director of the bank since
1983. In 1993, Mr. Sheaffer also became Chairman and Chief Executive  Officer of
Riverview  Savings Bank and Riverview  Mutual  Holding  Company,  a bank holding
company. He has been a director of the Washington Savings League since 1980.


D I R E C T O R S'   M E E T I N G S

         The Board held 18 meetings  during the fiscal year ended  September 30,
1997.  Each  director  attended  more than 75 percent of the  combined  total of
meetings  of the Board  and of  committees  of the  Board on which the  director
served at any time  during the year,  except R.  Douglas  Norby who  attended 59
percent of the combined total of meetings.

C O M M I T T E E S   O F   T H E   B O A R D

         The  Board  has  designated  an  Executive  Committee  to assist in the
discharge of the Board's  responsibilities.  The Executive Committee is composed
of four directors,  Roger L. Pringle,  Chairman,  W. Charles Armstrong,  John W.
Morgan and Michael J. Paxton.  The Executive  Committee met two times during the
fiscal year ended


                                                                               5
<PAGE>


September 30, 1997.  The Executive  Committee may exercise all the authority and
powers  of the  Board in the  management  of the  business  and  affairs  of the
Company,  except those reserved to the Board by the Oregon Business  Corporation
Act or the Company's bylaws.

         The  Executive  Compensation  Committee  of the Board  establishes  and
reviews from time to time  compensation  for executive  officers of the Company,
administers the Company's Incentive Stock Option Plan for Key Employees ("ISOP")
and 1991 Stock Award Plan (the  "Plan"),  and performs  other tasks as the Board
may direct.  Members of the  Executive  Compensation  Committee  are W.  Charles
Armstrong,  Chairman,  G. Patrick Sheaffer and R. Douglas Norby, none of whom is
eligible  to  participate  in the  Company's  compensation  plans  other than to
receive options awarded to nonemployee  directors of the Company pursuant to the
Plan.  See  EXECUTIVE   COMPENSATION  -  Compensation   of  Directors  -  Equity
Compensation.  The  Executive  Compensation  Committee  met ten times during the
fiscal year ended September 30, 1997.

         The  Audit   Committee  of  the  Board  reviews  the   performance  and
independence  of the  Company's  independent  accountants.  Members of the Audit
Committee are G. Patrick  Sheaffer,  Chairman,  R. Douglas  Norby,  and Roger L.
Pringle. The Audit Committee met once during the fiscal year ended September 30,
1997.

         The Nominating Committee of the Board solicits and recommends potential
candidates  for  membership  on the  Board  of  Directors.  The  members  of the
Nominating  Committee  are Roger L.  Pringle,  Chairman,  Andrew  S.  Goldstein,
Margaret H. Jordan and John W. Morgan. The Nominating Committee was appointed in
fiscal  year 1998 and  accordingly  did not meet  during the  fiscal  year ended
September 30, 1997.

         The  Nominating   Committee  will  consider  nominees   recommended  by
shareholders. Shareholders wishing to recommend a candidate for consideration by
the  Nominating  Committee  should  submit  information  about the  candidate in
writing to the Company at the address and by the deadline stated under "Deadline
for Shareholder Proposals."

         The Company's Bylaws provide that nominations for election to the Board
may be made by the Board or by any shareholder entitled to vote for the election
of directors. Notice of a shareholder's intent to make such a nomination must be
given in writing,  by personal delivery or certified mail,  postage prepaid,  to
the  Secretary  of the  Company  and must  include  the name and  address of the
shareholder and each proposed nominee, a representation  that the shareholder is
a record  holder of Common  Stock and intends to appear in person or by proxy at
the  shareholder  meeting to  nominate  the person or persons  specified  in the
notice,  a description of any arrangements or  understandings  pursuant to which
the nominations are to be made, the consent of each proposed nominee to serve as
a director if elected,  and such other  information  regarding  each  nominee as
would be required to be included in the Company's proxy statement had the person
been nominated by the Board. Such notice, with respect to an election to be held
at an annual meeting of shareholders,  must be given at least 60 days in advance
of the  anniversary  of the  date  of the  previous  year's  annual  meeting  of
shareholders  or,  with  respect  to  an  election  to  be  held  at  a  special
shareholders  meeting,  must be given no later than the close of business on the
seventh day  following  the date on which notice of such meeting was first given
to shareholders.


6
<PAGE>


                               EXECUTIVE OFFICERS

         The table below gives information about the current executive  officers
of the Company.


<TABLE>
     Name                                   Age                                Position
- ----------------------------------------------------------------------------------------------------------

<S>                                         <C>                        <C>
John W. Morgan                              38                         President, Chief Executive Officer,
                                                                       and Director

Charles E. Bergeron                         52                         Chief Financial Officer

J. Richard George, Ph.D.                    56                         Chief Scientific Officer

Andrew S. Goldstein                         49                         Senior Vice President of Advanced
                                                                       Technology Development - Epitope
                                                                       Medical Products, Secretary and
                                                                       Director
</TABLE>

         Officers of the Company hold office at the discretion of the Board.

         For  biographical  summaries  of Mr.  Morgan  and  Mr.  Goldstein,  see
ELECTION OF DIRECTORS.

         Charles E.  Bergeron  has been Chief  Financial  Officer of the Company
since January 1998. He has served as Chief  Financial  Officer - Epitope Medical
Products  since  September  1997,  and has been Vice  President of  Operations -
Epitope  Medical  Products since July 1995. Mr.  Bergeron  joined the Company in
August 1993 as President and Chief Executive  Officer,  Agrimax Floral Products,
Inc., then a wholly-owned subsidiary. From 1978 to 1992, Mr. Bergeron was Senior
Vice President - Finance of Freightliner Corporation,  a Portland, Oregon, truck
manufacturer.  He holds a B.S.  degree  in  Management  Engineering  and an M.S.
degree in Management Science from Rensselaer Polytechnic Institute and a Masters
of Business Administration degree from Columbia University.

         J. Richard George,  Ph.D., has been Chief Scientific Officer of Epitope
since  January  1998.  He joined the  Company as Vice  President  of  Scientific
Affairs - Epitope Medical Products in March 1995. A career scientist, Dr. George
previously  served the  Centers  for Disease  Control  and  Prevention  ("CDC"),
Atlanta,  Georgia,  which he joined in 1960. He held a series of management  and
technical  positions  at the  CDC,  becoming  Chief,  Developmental  Technology,
Laboratory  Investigations  Branch,  Division of HIV/AIDS in 1988. He holds B.S.
and M.S. degrees from Georgia State University and a Ph.D. in microbiology  from
the University of Georgia.


                                                                               7
<PAGE>


                             EXECUTIVE COMPENSATION

S U M M A R Y   C O M P E N S A T I O N   T A B L E

         The following table  summarizes the compensation of all individuals who
served as Chief  Executive  Officer  during  fiscal year 1997 and the four other
most highly  compensated  individuals who were serving as executive  officers of
the Company at September 30, 1997.

<TABLE>
                                                                                Long-Term
                                                                                Compensation
                                           Annual Compensation                     Awards
                                           -------------------                  ------------

                                                                                Securities
                                                                                Underlying       All Other
Name and Principal Position          Year       Salary          Bonus           Options(#)(1)   Compensation(2)
- ----------------------------------------------------------------------------------------------------------------

<S>                                   <C>     <C>             <C>                <C>              <C>        
Adolph J. Ferro, Ph.D. (3)            1997    $ 240,000       $      -           296,204(4)       $440,773(5)
President and Chief Executive         1996      214,183         50,000                 -             4,237
Officer                               1995      200,769        113,245            74,000             5,390

W. Charles Armstrong (3)              1997            -              -            30,000(4)              -
Interim President and Chief           1996            -              -                 -                 -
Executive Officer                     1995            -              -                 -                 -

Joseph A. Bouckaert                   1997      160,000              -            50,000(4)          4,000
President and Chief Executive         1996      160,000         33,600            50,000                 -
Officer - Vinifera, Inc.              1995      115,592         40,000                 -                 -

John H. Fitchen, M.D.                 1997      178,740              -            88,800(4)          4,327
Senior Vice President and Chief       1996      147,548         37,200                 -             3,540
Operating Officer - Epitope           1995      148,606              -            43,000             3,578
Medical Products

Andrew S. Goldstein                   1997      149,163              -            94,000(4)          3,750
Senior Vice President of              1996      128,510         30,000                 -             3,206
Advanced Technology                   1995      126,923              -            34,000             3,182
Development - Epitope Medical
Products

Gilbert N. Miller                     1997      165,000              -            85,104(4)          4,125
Executive Vice President and          1996      128,510         33,075                 -             3,206
Chief Financial Officer               1995      130,962              -            34,000             5,021
</TABLE>


(1)      Represents  the number of shares for which  options  were  awarded.  No
         stock  appreciation  rights  ("SARs")  have been  granted  to any named
         executive officer during the years indicated.

(2)      Includes  amounts  contributed  to the Company's  401(k) Profit Sharing
         Plan as employer matching contributions in the form of Common Stock.

(3)      Dr.  Ferro  served as  President  and Chief  Executive  Officer  of the
         Company through May 1997, at which time Mr.  Armstrong was appointed to
         this  position  on an  interim  basis and Dr.  Ferro  began  serving as
         President and Chief Executive Officer of Agritope on a full-time basis.


8
<PAGE>




(4)      Option  grants  for  fiscal  year 1997  consist  solely of  replacement
         options granted to effect the repricing of outstanding options,  except
         for an option to purchase 40,000 shares granted to Dr. Ferro to replace
         an  expiring  option  for the same  number of  shares  and an option to
         purchase 15,0000 shares granted to Mr.
         Armstrong.

(5)      Includes  $436,764 payable in installments  over 22 months to Dr. Ferro
         pursuant to his employment  agreement  with the Company,  in connection
         with the change of his  position  from  President  and Chief  Executive
         Officer of Epitope to full-time  President and Chief Executive  Officer
         of Agritope, Inc. in May 1997.

O P T I O N   G R A N T S   I N   L A S T   F I S C A L   Y E A R

<TABLE>
                                                   Individual Grants (1)

                                                  Percent of                                  Potential Realizable Value at Assumed
                                                    Total                                          Annual Rates of Stock Price
                                 Number of         Options                      Market           Appreciation for Option Term (2)
                                 Securities       Granted to      Exercise      Price         -------------------------------------
                                 Underlying       Employees        Price       on Date
                                  Options         in Fiscal         Per           of
            Name                  Granted            Year          Share        Grant           0%            5%               10%
- ------------------------------------------------------------------------------------------------------------------------------------

<S>                                 <C>                <C>         <C>            <C>        <C>           <C>          <C>       
Adolph J. Ferro, Ph.D.(3)           296,204            12.0%       $ 7.25         7.25       $       -     $1,350,394   $3,422,637

W. Charles Armstrong                 15,000              .6%         5.72         7.63          28,650        100,620      211,050
                                     15,000              .6%         7.25         7.25               -         68,385      173,325

Joseph A. Bouckaert                  50,000             2.0%         7.25         7.25               -        227,950      577,750

John H. Fitchen, M.D.                88,800             3.6%         7.25         7.25               -        404,839    1,026,084

Andrew S. Goldstein                  94,000             3.8%         7.25         7.25               -        428,546    1,086,170

Gilbert N. Miller                    85,104             3.4%         7.25         7.25               -        387,989      983,376
</TABLE>



(1)      Option  grants  for  fiscal  year 1997  consist  solely of  replacement
         options granted to effect the repricing of outstanding options,  except
         for an option to purchase 40,000 shares granted to Dr. Ferro to replace
         an  expiring  option  for the same  number of  shares  and an option to
         purchase   15,000  shares  granted  to  Mr.   Armstrong.   Options  are
         nonqualified  options with an unlimited  term,  except that the options
         granted to Dr.  Ferro and Mr.  Armstrong  have terms of ten years.  The
         holder's right to exercise the options will terminate  immediately upon
         the  termination of employment for cause,  will expire five years after
         retirement,  and will  expire  one year  after  death,  disability,  or
         ceasing to be an active employee of the Company, Agritope, Inc., or its
         subsidiaries for any other reason.  Subject to certain conditions,  the
         exercise  price of the options  may be paid by  delivery of  previously
         acquired  shares of Common  Stock.  No SARs were granted  during fiscal
         1997.

(2)      The amounts shown are hypothetical gains based on the indicated assumed
         rates of  appreciation  of the Common Stock  compounded  annually for a
         ten-year  period.  Although,  as  described  in more detail in note (1)
         above, the options shown in the table have either a ten-year term or an
         unlimited  term  subject to  expiration  at specified  times  following
         termination  of  employment,   a  ten-year  period  has  been  used  in
         calculating  thc  amounts  shown as an  approximation  of the  expected
         average time during which the options will be outstanding. There can be
         no assurance  that the Common Stock will  appreciate at any  particular
         rate or at all in future years.

(3)      Includes an option for 40,000  shares  granted to Dr. Ferro on June 16,
         1997, to replace an expiring option for the same number of shares.  The
         initial  exercise price per share was $7.75 and the market price on the
         date of grant was $7.63 per share.  The option was repriced on July 26,
         1997, together with other options held by Dr. Ferro to purchase 256,204
         shares of Common Stock.


                                                                               9
<PAGE>


F I S C A L   Y E A R - E N D   O P T I O N   V A L U E S  (1)

<TABLE>
                                            Number of Securities Underlying                      Value of Unexercised In-the-
                                             Unexercised Options at Fiscal                      Money Options at Fiscal Year-
                                                       Year-End                                            End (2)
                                      -------------------------------------------        -------------------------------------------

                Name                       Exercisable         Unexercisable                   Exercisable         Unexercisable
- ------------------------------------------------------------------------------------------------------------------------------------

<S>                                         <C>                    <C>                         <C>                   <C>     
Adolph J. Ferro, Ph. D.                     531,536                24,668                      $ 693,044             $ 19,981

W. Charles Armstrong                         75,000                 5,000                        127,468                4,050

Joseph A. Bouckaert                          25,000                25,000                         20,250               20,250

John H. Fitchen, M.D.                       174,466                14,334                        228,817               11,611

Andrew S. Goldstein                         182,666                11,334                        235,459                9,181

Gilbert N. Miller                           197,770                11,334                        301,694                9,181
</TABLE>




(1)      The named  executive  officers  neither  exercised  any options or SARs
         during fiscal 1997 nor held any SARs at September 30, 1997.

(2)      In-the-money  stock options are options for which the exercise price is
         less than the  market  value of the  underlying  stock on a  particular
         date. The values shown in the table are based on the difference between
         $8.06,  which was the  average of the high and low sales  prices of the
         Common  Stock as quoted on The Nasdaq  Stock  Market on  September  30,
         1997, and the applicable exercise price.


10
<PAGE>


T E N - Y E A R   O P T I O N   R E P R I C I N G S

         On July 26, 1997,  the Board and its Executive  Compensation  Committee
authorized  the  repricing  of all  outstanding  options  held by  directors  or
employees  that  were  then   out-of-the-money.   The  table  below  sets  forth
information about the repricing, which was the only repricing of options held by
directors or executive  officers during the last ten completed  fiscal years. No
SARs have been issued or repriced by the Company.


<TABLE>
                                                                      Market Price of
                                            Number of Shares           Common Stock          Exercise Price at        New
                                           Underlying Options           at Time of           Time of Repricing     Exercise
                 Name                           Repriced                 Repricing                  (1)              Price
- ----------------------------------------------------------------------------------------------------------------------------

<S>                                               <C>                     <C>                    <C>               <C>   
Adolph J. Ferro, Ph. D.                           60,000                  $ 7.25                 $ 7.3750          $ 7.25
                                                  82,204                    7.25                  13.6875            7.25
                                                  74,000                    7.25                  14.9375            7.25
                                                  40,000                    7.25                   7.7500            7.25

W. Charles Armstrong                              15,000                    7.25                  18.3750            7.25

Joseph A. Bouckaert                               50,000                    7.25                  13.5000            7.25

John H. Fitchen, M.D.                             45,800                    7.25                   8.1875            7.25
                                                  43,000                    7.25                  14.9375            7.25

Andrew S. Goldstein                               60,000                    7.25                   7.3750            7.25
                                                  34,000                    7.25                  14.9375            7.25

Gilbert N. Miller                                 10,000                    7.25                   7.3750            7.25
                                                  41,104                    7.25                  13.6875            7.25
                                                  34,000                    7.25                  14.9375            7.25
</TABLE>



(1)      All options were repriced on July 26, 1997. The original options had an
         unlimited  term,  but  the  holder's  right  to  exercise  the  options
         terminated  immediately  upon the  termination of employment for cause,
         five years after retirement,  or one year after death,  disability,  or
         ceasing to be an active employee of the Company, Agritope, Inc., or its
         subsidiaries for any other reason.


E M P L O Y M E N T   A G R E E M E N T S

         Pursuant to written employment agreements with the Company, all current
executive  officers  are  entitled to receive one year of salary in the event of
termination  without  cause  (two  years  in  the  case  of  Mr.  Goldstein  for
termination  in  connection  with a  change  in  control  of the  Company).  The
agreements  with Messrs.  Morgan and  Bergeron  permit them to treat a change in
control and certain other events as a termination  without cause. The agreements
with Messrs.  Morgan,  Bergeron and  Goldstein in each case prohibit the officer
from  competing  with the  Company  for one year  after  termination  unless the
officer elects to waive the right to amounts  otherwise  payable.  The agreement
with Dr. George makes any post-termination  payment contingent on his refraining
from competing with the Company. The agreements do not expire by their terms and
are  terminable by the Company with cause (upon 90 days' notice,  in the case of
Mr.  Goldstein) or, subject to payment of the salary  amounts  described  above,
without cause.

         Mr. Morgan relocated from the Atlanta,  Georgia area when he joined the
Company in fiscal year 1998.  The Company has agreed to reimburse Mr. Morgan for
relocation  expenses,  and to pay up to an  additional  $50,000 to cover realtor
fees, closing costs,  furniture storage costs and other  miscellaneous  expenses
relating to his relocation.


                                                                              11
<PAGE>


         Mr.  Morgan has been  granted an option to purchase  350,000  shares of
Common Stock, one-third of which vests after one year and the remainder of which
vests  in  monthly  installments  over  the  following  24  months.  Vesting  is
accelerated  in case of a change in control of the Company and continues for one
year after termination of Mr. Morgan's  employment without cause. Mr. Morgan may
exercise  the option prior to vesting  under an agreement  giving the Company an
option upon termination of Mr. Morgan's  employment to repurchase any shares for
which the option has been  exercised but as to which the option is not vested at
the termination date.

C O M P E N S A T I O N   O F   D I R E C T O R S

         Under  the  Company's  1991  Stock  Award  Plan  ("Plan"),  nonemployee
directors of the Company are  eligible to receive  nonqualified  stock  options.
Such options have been granted to nonemployee  directors on the basis  described
below. The Board may decide to grant options on other terms and in other amounts
at any time.

         Initial  Options.  Each person who becomes a  nonemployee  director has
been  granted  a stock  option to  purchase  50,000  shares of Common  Stock (an
"Initial  Option").  A newly-elected  Chairman of the Board has been entitled to
receive an Initial Option to purchase an additional 25,000 shares (75,000 shares
if not previously a nonemployee director).  Until December 1994, Initial Options
were  granted at an exercise  price equal to 75 percent of the fair market value
of a share of Common  Stock on the date of grant;  beginning  in December  1994,
Initial  Options have been granted at an exercise price equal to the fair market
value of a share on the date of grant  minus  the  lesser of (a) $2.00 or (b) 25
percent of such fair market value.  Each Initial Option  becomes  exercisable in
annual  installments  based upon continued  service as a director and expires at
the end of five years following the director's  retirement or one year following
the director's  death,  disability or cessation of service as a director for any
other reason.  An Initial Option will generally become fully  exercisable by the
date of the fourth annual meeting of shareholders through which the director has
served on the Board. Initial Options become exercisable in full immediately upon
the occurrence of a change in control of the Company. A change in control of the
Company would occur on the happening of such events as the beneficial  ownership
by a person or group of 30  percent  or more of the  outstanding  common  stock,
certain changes in Board membership  affecting a majority of positions,  certain
mergers or consolidations,  a sale or other transfer of all or substantially all
the Company's  assets,  or approval by the shareholders of a plan of liquidation
or dissolution of the Company,  as well as any change in control  required to be
reported by the proxy disclosure rules of the Commission.

         Payment of the  exercise  price may be made in cash or by  delivery  of
previously  acquired  shares of Common Stock having a fair market value equal to
the aggregate  exercise  price. To the extent that payment is made in previously
acquired shares, the director is automatically granted a replacement  ("reload")
option for a number of shares equal to the number  delivered  upon exercise with
an exercise  price equal to the fair market  value of a share of Common Stock on
the date of exercise. Reload options become exercisable in full six months after
the grant date.

         Renewal  Options.  Additional  nonqualified  stock  options  have  been
granted to each  nonemployee  director to purchase 15,000 shares of Common Stock
("Renewal  Options")  as of the  December  15 prior  to the  annual  meeting  of
shareholders  at which the options  most  recently  granted to such  nonemployee
director  fully vest.  Renewal  Options vest in three equal annual  installments
beginning with the second annual meeting of  shareholders  following the date of
grant,  subject to  acceleration  of vesting upon the  occurrence of a change in
control of the Company.  The other terms of Renewal  Options are  comparable  to
those of Initial Options,  except that Renewal Options do not provide for reload
options.


                 REPORT OF THE EXECUTIVE COMPENSATION COMMITTEE

         The  following  report of the Executive  Compensation  Committee of the
Board (the "Committee") shall not be deemed to be incorporated by reference into
any  previous  filing by the Company  under  either the  Securities  Act of 1933
("Securities Act") or the Securities  Exchange Act of 1934 ("Exchange Act") that
incorporates  future  Securities Act or Exchange Act filings in whole or in part
by reference.


12
<PAGE>


         GENERAL. The Committee,  which is composed of independent,  nonemployee
directors,  is responsible  for  establishing  and  administering  the Company's
policies that govern executive compensation and benefit practices. The Committee
evaluates the performance of the executive officers and determines their salary,
merit cash bonus and related benefits.  The Committee also grants certain awards
under the Company's stock option plans.

         COMPENSATION PHILOSOPHY.  The Company's executive compensation programs
are  designed  to (i) align  the  interests  of  executive  management  with the
long-term  interests of the  shareholders,  (ii) motivate Company  executives to
achieve  the  strategic  business  goals  of the  Company  and  recognize  their
individual contributions, and (iii) provide compensation opportunities which are
competitive with those offered by other national biotechnology companies similar
in size and  performance  to the Company.  In  furtherance  of these goals,  the
components of executive  compensation  include base salary,  merit cash bonuses,
stock option grants and other benefits and are linked to individual performance.

         BASE SALARY.  At least annually,  the Committee sets the salary for all
executive   officers.   The   Committee   receives  and   considers   management
recommendations concerning salary adjustments for executive officers, as well as
compensation  data  regarding  other  national  biotechnology   companies.   The
Committee decided to increase the salaries of executive officers,  including the
chief executive  officer,  for fiscal year 1997 based on events occurring at the
time  that  indicated  a  substantial  improvement  in  the  Company's  business
prospects.  These events included initial  implementation  of the targeted stock
proposal and the plan to acquire Andrew and Williamson Sales, Co.

         MERIT CASH  BONUSES.  No merit cash bonuses were awarded  during fiscal
year 1997.

         STOCK OPTION  GRANTS.  As previously  noted,  an important  goal of the
Company's  compensation  program  is to align  the  interests  of the  executive
officers and other key employees  with the long-term  interests of the Company's
shareholders.  In furtherance  of this goal, the Board of Directors  adopted the
1991 Stock Award Plan pursuant to which the Company may grant stock-based awards
to directors,  officers,  and employees of, and consultants and advisers to, the
Company. The Plan was approved by the shareholders of the Company.

         During  the  Company's  fiscal  year  ended  September  30,  1997,  the
Committee authorized the repricing of outstanding options held by employees,  as
described below. The Committee authorized the grant of options for 40,000 shares
of Common Stock to Dr. Ferro to replace options that were expiring,  and options
for 15,000  shares of Common  Stock to Mr.  Armstrong,  who was then  serving as
interim  President and Chief  Executive  Officer.  No other options were granted
under the Plan to executive  officers  during the fiscal year.  In general,  the
size of individual  option grants is determined by the Committee  based upon the
executive's  duties  and  the  levels  of  option  grants  for  executives  with
comparable  positions at other biotechnology  companies.  The Committee does not
consider the amount and terms of options  already held by executive  officers in
making new grants.

         OTHER  COMPENSATION  VEHICLES.  The  Company  also has a 401(k)  Profit
Sharing Plan (the "401(k) Plan") which allows participants to defer compensation
pursuant to Section  401(k) of the Internal  Revenue Code.  All employees of the
Company,  including  executives,  are eligible to participate in the 401(k) Plan
provided  certain   qualifications   are  met.  In  addition  to  amounts  which
participants  may elect to  contribute  to the 401(k)  Plan,  the Company  makes
matching  contributions to the 401(k) Plan in Common Stock of the Company, which
are allocated to all participants.  Payments of benefits accrued for 401(k) Plan
participants  will be made upon  retirement  or upon  termination  of employment
prior to retirement  provided  certain  conditions have been met by the employee
prior to termination.

         OPTION  REPRICING.   As  noted  above,  the  Committee  authorized  the
repricing of options held by all employees,  including  executive  officers,  in
July 1997. The Committee believed that, as a result of a decline in the price of
the Common Stock, outstanding options were ineffective to serve the purposes for
which they were granted under the Plan,  namely to align the interests of option
holders with the long-term interests of the Company's


                                                                              13
<PAGE>


shareholders.  The Committee  authorized the repricing of  outstanding  employee
options  using a price  equal to fair  market  value,  in order to  restore  the
utility of the options as effective incentives.

EXECUTIVE COMPENSATION COMMITTEE:

W. Charles Armstrong, Chairman
R. Douglas Norby
G. Patrick Sheaffer


           COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

         W. Charles  Armstrong  served as chairman and a member of the Executive
Compensation  Committee through May 1997.  Beginning in June 1997, Mr. Armstrong
served as interim  President and Chief  Executive  Officer of the Company.  When
John W. Morgan  joined the Company as President and Chief  Executive  Officer in
October  1997,  Mr.  Armstrong was  reappointed  as chairman and a member of the
Committee.

         R.  Douglas  Norby and G.  Patrick  Sheaffer  served as  members of the
Committee throughout fiscal year 1997.


14
<PAGE>


                          STOCK PRICE PERFORMANCE GRAPH

         The following graph compares the cumulative  total returns to investors
in the  Company's  Common Stock,  the Standard & Poors 500 Stock Index,  and the
Russell 2000 Index for the period from October 1, 1992,  through  September  30,
1997.  The graph  assumes that $100 was invested on September  30, 1992,  in the
Company's Common Stock and in each of the  above-mentioned  indices and that all
dividends were reinvested.  The Russell 2000 Index is an index of companies with
market capitalizations  similar to the Company. It has been selected because the
Company has been unable to identify a peer group of companies for comparison. No
single  public or private  company has a comparable  mix of  technologies  under
development  or  products  which  serve the same  markets  as the  Company.  The
Company's  management  believes that an index of companies  with similar  market
capitalizations  provides a reasonable  basis for  comparing  total  shareholder
returns.  Shareholders  are  cautioned  that the  graph  shows  the  returns  to
investors  only as of the  dates  noted  and may  not be  representative  of the
returns for any other past or future period.

                 COMPARISON OF FIVE YEAR CUMULATIVE TOTAL RETURN
       AMONG EPITOPE INC., THE S & P 500 INDEX AND THE RUSSELL 2000 INDEX

[GRAPHICAL CHART CONTAINING THE FOLLOWING INFORMATION:

<TABLE>
DATE                      EPITOPE,  INC.                    S&P 500                    RUSSELL 2000
- ----                      --------------                    -------                    ------------

<S>                       <C>                               <C>                         <C>   
9/92                      $  100                            $  100                      $  100
9/93                         129                               113                         133
9/94                         120                               117                         137
9/95                          84                               152                         169
9/96                          83                               183                         191
9/97                          50                               254                         254]
</TABLE>


                                                                              15
<PAGE>


                              CERTAIN TRANSACTIONS

         In  connection  with the December 1987 merger of  Agricultural  Genetic
Systems,  Inc.  ("AGS"),  with and into  Agritope,  Dr.  Ferro,  as an executive
officer and  principal  shareholder  of AGS,  was  granted a royalty  equal to 4
percent of net sales of products  resulting from the  technology  transferred to
Agritope pursuant to the merger;  royalties with respect to a particular product
were to be paid for a period  equal to the life of the patent on the  product or
an equivalent  period if a patent is not issued. On November 11, 1996, Dr. Ferro
agreed to accept a one-time  payment of $590,000 in lieu of the  royalties  that
would otherwise be due him.

                                  ANNUAL REPORT

         The Company's  Annual Report to Shareholders  for the fiscal year ended
September 30, 1997,  accompanies this proxy statement.  On written request,  the
Company will provide,  without charge,  a copy of its Annual Report on Form 10-K
for the  fiscal  year  ended  September  30,  1997,  filed  with the  Commission
(including a list briefly describing the exhibits thereto), to any record holder
or  beneficial  owner of the  Company's  Common Stock on December 22, 1997,  the
record date for the Annual Meeting,  or to any person who  subsequently  becomes
such a record holder or  beneficial  owner.  Requests  should be directed to the
attention  of the  Secretary  of the  Company at the  address of the Company set
forth in the Notice of Annual Meeting of Shareholders immediately preceding this
proxy statement.

                             INDEPENDENT ACCOUNTANTS

         Price  Waterhouse LLP,  independent  public  accountants,  examined the
financial  statements of the Company for fiscal 1997.  No change in  independent
public  accountants  is  contemplated  for  fiscal  1998.  The  Company  expects
representatives  of Price Waterhouse LLP to be present at the Annual Meeting and
to be available  to respond to  appropriate  questions  from  shareholders.  The
accountants will have the opportunity to make a statement at the meeting if they
desire to do so.

                       DEADLINE FOR SHAREHOLDER PROPOSALS

         Shareholders  of the Company may submit  proposals for inclusion in the
proxy material for the Company's 1999 Annual Meeting of  Shareholders.  Any such
proposals must meet the shareholder  eligibility and other requirements  imposed
by rules  issued by the  Commission  and must be received by the Company at 8505
S.W. Creekside Place, Beaverton,  Oregon 97008, Attention:  Secretary, not later
than September 18, 1998.

BY ORDER OF THE BOARD OF DIRECTORS
Andrew S. Goldstein
Secretary
January 16, 1998


16
<PAGE>
PROXY

                                  EPITOPE, INC.
                       1998 ANNUAL MEETING OF SHAREHOLDERS
               PROXY SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS


The undersigned hereby appoints John W. Morgan and Charles E. Bergeron, and each
of them,  proxies  with full  power of  substitution,  to vote all of the shares
which  the  undersigned  is  entitled  to vote at the  1998  Annual  Meeting  of
Shareholders of Epitope, Inc. (the "Company"),  to be held on Tuesday,  February
17, 1998, and at any further adjournment or adjournments  thereof,  with all the
powers the undersigned would possess if personally present,  with respect to the
matters listed on the reverse side.

THE SHARES  REPRESENTED BY THIS PROXY,  IF PROPERLY  EXECUTED,  WILL BE VOTED AS
SPECIFIED ON THE REVERSE SIDE OR, IF NO SPECIFICATION IS MADE, WILL BE VOTED FOR
THE ELECTION OF THE NOMINEES  LISTED ON THE REVERSE  SIDE AS  DIRECTORS.  If any
other business  properly comes before the meeting,  the proxies named above will
have  discretionary  authority  to vote  thereon in  accordance  with their best
judgment.

          PLEASE MARK, DATE, SIGN, AND RETURN THE PROXY CARD PROMPTLY.
                 (Continued and to be signed on reverse side.)



                              FOLD AND DETACH HERE






                                  EPITOPE, INC.


                       1998 Annual Meeting of Shareholders

                           Tuesday, February 17, 1998



<PAGE>


                         Please mark your votes as indicated in this example [X]

1.       Election of Directors                       FOR        WITHHOLD
         Class I (Term Expiring 2000)                [ ]        [ ]
                  John W. Morgan
         Class III (Term Expiring 2001)
                  Margaret H. Jordan
                  Michael J. Paxton

(Instruction: To withhold authority to vote for any individual nominee, mark FOR
and strike a line  through the  nominee's  name in the list  above.  To withhold
authority to vote for all nominees, mark WITHHOLD.)




Signature(s) ------------------------------------ Dated: -----------------, 1998

Please date and sign exactly as your name appears on this Proxy.  If signing for
estates,  trusts,  partnerships  or  corporations,  title or capacity  should be
stated. If shares are held jointly, each holder should sign.





                              FOLD AND DETACH HERE






                                  EPITOPE, INC.


                       1998 ANNUAL MEETING OF SHAREHOLDERS

                           TUESDAY, FEBRUARY 17, 1998




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