EPITOPE INC/OR/
DEF 14A, 1999-01-11
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
Previous: DONEGAL GROUP INC, SC 13D/A, 1999-01-11
Next: WINTER SPORTS INC /NEW, 10QSB/A, 1999-01-11



                           SCHEDULE 14A INFORMATION
Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934
(Amendment No.  )

Filed by the Registrant [x]
Filed by a Party other than the Registrant [ ]

Check the appropriate box:
[ ] Preliminary Proxy Statement          [ ] Confidential, for Use of 
[x] Definitive Proxy Statement                 the Commission Only (as
[ ] Definitive Additional Materials            permitted by 
[ ] Soliciting Material Pursuant to            Rule 14a-6(e)(2))
            Rule 14a-11(c) 
            or Rule 14a-12

                                  Epitope, Inc.
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified In Its Charter)

- --------------------------------------------------------------------------------
    (Name of  Person(s)  Filing Proxy  Statement  if other than the  Registrant)

Payment of Filing Fee (Check the appropriate box):
[x] No fee required.
[ ] Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.

    1)  Title of each class of securities to which transaction applies:

- --------------------------------------------------------------------------------
    2)  Aggregate number of securities to which transaction applies:

- --------------------------------------------------------------------------------
    3)  Per unit  price  or  other  underlying  value  of  transaction  computed
    pursuant to Exchange Act Rule 0-11 (set forth the amount on which the filing
    fee is calculated and state how it was determined):

- --------------------------------------------------------------------------------
    4)  Proposed maximum aggregate value of transaction:
    
- --------------------------------------------------------------------------------
    5)  Total fee paid:
    
- --------------------------------------------------------------------------------

[ ] Fee paid previously with preliminary materials.

[ ] Check box if any part of the fee is offset as provided by Exchange  Act Rule
0-11(a)(2)  and  identify  the  filing  for  which the  offsetting  fee was paid
previously.  Identify the previous filing by registration  statement  number, or
the form or schedule and the date of its filing.

    1)  Amount Previously Paid:
    
- --------------------------------------------------------------------------------
    2)  Form, Schedule or Registration Statement No.:
    
- --------------------------------------------------------------------------------
    3)  Filing Party:
    
- --------------------------------------------------------------------------------
    4)  Date Filed:
    
- --------------------------------------------------------------------------------
<PAGE>
                            [Graphic: Epitope logo]

                                     EPITOPE
                            8505 S.W. Creekside Place
                             Beaverton, Oregon 97008


                                                                January 11, 1999

Dear Shareholder:

         You are  cordially  invited  to  attend  the  1999  Annual  Meeting  of
Shareholders to be held on TUESDAY,  FEBRUARY 16, 1999, at the Oregon Convention
Center,  777 N.E. Martin Luther King Jr.  Boulevard,  Portland,  Oregon, at 9:00
a.m. Your Board of Directors and management look forward to personally  greeting
those  present.  At the  meeting,  you will be asked  to  elect  three  Class II
directors  to serve on the  Board of  Directors  until  the  Annual  Meeting  of
Shareholders  in the year  2002;  and to  transact  such other  business  as may
properly come before the meeting or any adjournments thereof.
         Your Board of Directors has approved the nominees for director named in
the enclosed Proxy  Statement and recommends that you vote FOR their election to
the Board of Directors.
         Your vote is very  important,  regardless  of the  number of shares you
own. Whether or not you plan to attend the Annual Meeting in person, we urge you
to  mark,  sign,  date,  and  mail  the  enclosed  proxy  card  promptly  in the
accompanying  postage prepaid  envelope.  You may, of course,  attend the Annual
Meeting and vote in person even if you have previously mailed your proxy card.

Sincerely yours,

/s/ John W. Morgan

John W. Morgan
President and Chief Executive Officer
<PAGE>


                                  EPITOPE, INC.
                            8505 S.W. Creekside Place
                             Beaverton, Oregon 97008
                                 ---------------

                    NOTICE OF ANNUAL MEETING OF SHAREHOLDERS
                          TO BE HELD FEBRUARY 16, 1999
                                 --------------


To the Shareholders of Epitope, Inc.:

         The  Annual  Meeting  of  Shareholders  of  Epitope,  Inc.,  an  Oregon
corporation (the "Company"),  will be held at the Oregon Convention  Center, 777
N.E.  Martin Luther King Jr.  Boulevard,  Portland,  Oregon  97232,  on TUESDAY,
FEBRUARY  16,  1999,  at 9:00 a.m.  to elect three  Class II  directors,  and to
consider  such other  business  as may  properly  come before the meeting or any
adjournments thereof. Additional information relevant to the meeting is included
in the proxy statement accompanying this Notice.

         Only  holders  of Common  Stock of record at the close of  business  on
December  15,  1998,  will  be  entitled  to  vote  at  the  Annual  Meeting  of
Shareholders and any adjournments thereof.

By Order of the Board of Directors


Andrew S. Goldstein
Secretary


January 11, 1999
Beaverton, Oregon






- --------------------------------------------------------------------------------
YOUR VOTE IS IMPORTANT.  WHETHER OR NOT YOU PLAN TO ATTEND THE MEETING,  YOU ARE
URGED TO MARK,  SIGN,  DATE,  AND  RETURN THE  ENCLOSED  PROXY  PROMPTLY  IN THE
ENVELOPE  PROVIDED.  RETURNING  YOUR PROXY DOES NOT DEPRIVE YOU OF YOUR RIGHT TO
ATTEND THE MEETING AND TO VOTE YOUR SHARES IN PERSON.
- --------------------------------------------------------------------------------
<PAGE>


                                  EPITOPE, INC.
                            8505 S.W. Creekside Place
                             Beaverton, Oregon 97008


                                   -----------



                                 PROXY STATEMENT

         This proxy  statement is being mailed on or about  January 11, 1999, to
shareholders  of  Epitope,  Inc.,  an Oregon  corporation  (the  "Company"),  in
connection with the solicitation of proxies in the accompanying form ("Proxies")
by the Board of  Directors  of the Company  (the  "Board") for use at the Annual
Meeting of  Shareholders  to be held on February 16, 1999,  at 9:00 a.m., at the
Oregon Convention Center,  777 N.E. Martin Luther King Jr. Boulevard,  Portland,
Oregon 97232, and at any adjournments  thereof (the "Annual Meeting"),  pursuant
to the accompanying Notice of Annual Meeting of Shareholders.


                                     PROXIES

         Shares  represented  by a  properly  executed  Proxy  will be  voted in
accordance  with the  shareholder's  instructions  indicated on the Proxy. If no
instructions are given, the shareholder's  shares will be voted according to the
recommendations of the Board as stated on the Proxy. Shareholders may revoke the
authority  granted  by their  Proxies at any time  before the Annual  Meeting by
notice in writing  delivered to the  Secretary of the Company,  by  submitting a
subsequently  dated proxy, or by attending the Annual  Meeting,  withdrawing the
Proxy, and voting in person.

         At the Annual Meeting, action will be taken on the matters set forth in
the accompanying  Notice of Annual Meeting of Shareholders and described in this
proxy statement.  The Board knows of no other matters to be presented for action
at the Annual  Meeting.  If any other matters do properly come before the Annual
Meeting,  the persons  named on the Proxy will have  discretionary  authority to
vote thereon in accordance with their best judgment.

         The  cost of  soliciting  Proxies  will be  borne  by the  Company.  In
addition to solicitations by mail, certain of the Company's directors, officers,
and regular employees may solicit Proxies personally or by telephone, telegraph,
or other means without  additional  compensation.  The Company has retained D.F.
King & Co., Inc., to assist in such  solicitation for an estimated fee of $2,500
plus reimbursement for certain expenses.

         Arrangements   will  also  be  made  with  brokerage  firms  and  other
custodians,  nominees,  and fiduciaries to forward solicitation  material to the
beneficial owners of stock held of record by such persons, and the Company will,
upon request, reimburse them for their reasonable expenses in so doing.


   PLEASE MARK, SIGN, AND DATE THE ENCLOSED PROXY CARD, AND RETURN IT PROMPTLY
               IN THE ENCLOSED ENVELOPE PROVIDED FOR THIS PURPOSE.

                                                                               1
<PAGE>


                                VOTING SECURITIES

         On December  15,  1998,  the record date for  determining  shareholders
entitled to vote at the Annual Meeting, the Company had outstanding and entitled
to vote at the  meeting  13,609,961  shares of Common  Stock,  no par value (the
"Common  Stock").  Each  share of Common  Stock is  entitled  to one vote on any
matter  brought  before the  meeting.  A majority of the shares of Common  Stock
outstanding  as of the  record  date,  represented  in person or by proxy at the
meeting, will constitute a quorum for the transaction of business.

                             PRINCIPAL SHAREHOLDERS

         The  following  table sets forth  information  as of December 28, 1998,
regarding the  beneficial  ownership of the  Company's  Common Stock by (a) each
person  who is known to the  Company to be the  beneficial  owner of more than 5
percent of the Common  Stock  outstanding,  (b) each  director  and  nominee for
election as director,  (c) each of the Company's executive officers named in the
Summary Compensation Table under EXECUTIVE  COMPENSATION,  and (d) all directors
and executive officers of the Company as a group.

<TABLE>
                                                                          Amount and Nature of             Percent
Beneficial Owner                                                      Beneficial Ownership (1) (2)         of Class
- -------------------------------------------------------------- ------------------------------------------- ------------

<S>                                                                         <C>                                <C> 
Putnam Investments, Inc., One Post Office Square, Boston, MA 02109            912,700(3)                       6.7%

W. Charles Armstrong                                                           89,540(4)                         *

Charles E. Bergeron                                                           146,985(4)                       1.1%

Edward V. Collom, Jr.                                                             440                            *

J. Richard George, Ph.D.                                                       64,365                            *

Andrew S. Goldstein                                                           447,509                          3.2%

Margaret H. Jordan                                                             51,000                            *

John W. Morgan                                                                165,215(4)(5)                    1.2%

Michael J. Paxton                                                              72,052                            *

Roger L. Pringle                                                              152,177(4)                       1.1%

G. Patrick Sheaffer                                                            95,000                            *

Robert J. Zollars                                                              20,000                            *

All directors and executive officers as a group (11 persons)                1,304,283(4)                       8.9%
- ---------
*Less than 1%
</TABLE>



(1)      Subject  to  community  property  laws  where  applicable,   beneficial
         ownership  consists  of sole  voting  and  investment  power  except as
         otherwise indicated.

(2)      Includes  shares  subject  to  options  exercisable  within  60 days of
         December  28, 1998,  as follows:  Mr.  Armstrong,  85,000  shares;  Mr.
         Bergeron,  144,832 shares;  Dr. George,  63,332 shares;

2
<PAGE>

         Mr. Goldstein,  200,250 shares; Ms. Jordan,  50,000 shares; Mr. Morgan,
         155,546 shares; Mr. Paxton, 70,552 shares; Mr. Pringle, 115,552 shares;
         Mr.  Sheaffer,  82,500 shares;  Mr.  Zollars,  20,000  shares;  and all
         directors and executive officers as a group, 987,564 shares.

(3)      Putnam Investments, Inc., a wholly owned subsidiary of Marsh & McLennan
         Companies,  Inc.,  filed a Schedule  13G report on  January  20,  1998,
         reporting  that it had  shared  voting  power as to 20,200  shares  and
         shared  dispositive  power  over  892,500  shares  as a  result  of its
         ownership of two registered investment advisers.

(4)      Includes  shares as to which  the  individual  has  shared  voting  and
         dispositive power as follows: Mr. Armstrong,  165 shares; Mr. Bergeron,
         2,153 shares; Mr. Morgan, 5,000 shares; Mr. Pringle,  1,500 shares; and
         all directors and executive officers as a group, 8,818 shares.

(5)      Does not include  33,554  shares of Common  Stock held in the  Epitope,
         Inc.  40l(k) Profit Sharing Plan (the "401(k)  Plan"),  as to which Mr.
         Morgan shares voting power as a trustee of the 401(k) Plan.  Mr. Morgan
         disclaims any economic beneficial interest in such shares.

             SECTION 16(A) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

         Section  16(a) of the  Securities  Exchange  Act of 1934  requires  the
Company's officers and directors and persons who own more than 10 percent of the
Common Stock  (collectively,  "Reporting  Persons") to file reports of ownership
and changes in  ownership  with the  Securities  and  Exchange  Commission  (the
"Commission"). Reporting persons are required by the Commission's regulations to
furnish the Company with copies of all Section 16(a) forms they file.

         Based  solely on its  review of the  copies of such  forms and  written
representations  regarding  the absence of a filing  requirement  received  from
Reporting  Persons,  the Company  believes  that with respect to the 1998 fiscal
year, all Reporting  Persons complied with all applicable  filing  requirements,
except that Roger L.  Pringle,  Chairman of the Board of the Company,  filed one
report reporting one transaction one month late due to a misunderstanding of the
applicable transaction date.
                              ELECTION OF DIRECTORS

         At the Annual Meeting,  shareholders will vote on the election of three
Class II  directors.  The  Nominating  Committee of the Board of  Directors  has
nominated Andrew S. Goldstein,  G. Patrick  Sheaffer,  and Robert J. Zollars for
election as Class II  directors,  for terms  expiring  at the Annual  Meeting of
Shareholders  in 2002.  The nominees for  election as  directors  are  presently
members of the Board; Mr. Zollars was appointed to the Board in February 1998 to
fill the vacancy occasioned by the resignation of R. Douglas Norby.

         In the absence of instructions to the contrary,  shares of Common Stock
represented by properly  executed  Proxies will be voted for the three nominees,
each of whom has  consented to be named and to serve if elected.  If a quorum is
present,  each  nominee will be elected if he or she receives a plurality of the
votes cast by shares  entitled to vote at the Annual  Meeting.  Abstentions  and
shares as to which a broker or other  nominee has  indicated on a duly  executed
and  returned  proxy or  otherwise  advised  the  Company  that it lacks  voting
authority will have no effect on the required vote.

         The Company does not know of anything  that would  preclude any nominee
from  serving.  However,  should any  nominee  for any reason  become  unable or
unwilling to serve as a director,  the persons named in the enclosed  Proxy will
vote the shares  represented  by each Proxy for such  substitute  nominee as the
Board may approve.

         Any vacancy that occurs  during the term of a director may be filled by
the affirmative  vote of a majority of the remaining  directors even though less
than a quorum of the Board.  The  vacancy  may be filled  until the next  annual
meeting  of  shareholders.  The  Nominating  Committee  of the Board has not yet
identified  a candidate  to fill a vacant  position in Class III of the Board of
Directors  created by the  resignation  of Richard K. Donahue in February  1998.
Proxies  may only be voted for Class II  directors  at the Annual  Meeting.  The
Nominating  Committee intends to 

                                                                               3
<PAGE>

continue to seek a qualified  individual to fill the remaining  vacancy prior to
the Annual Meeting of Shareholders in 2000.

Certain  information  with  respect to each person  nominated  for election as a
director and each person whose term of office as a director will continue  after
the Annual Meeting is set forth below.
<TABLE>
                                                                                               Director
Name                                        Principal Occupation                Age              Since
- -------------------------------------------------------------------------------------------------------------------

Class I (Directors Whose Terms of Office Expire in 2000):

<S>                                 <C>                                         <C>              <C> 
W. Charles Armstrong                Former Chairman and Chief Executive         54               1989
                                    Officer of Bank of America Oregon

John W. Morgan                      President and Chief Executive               39               1998
                                    Officer of the Company

Roger L. Pringle                    President of The Pringle Company,           58               1989
                                    a management consulting firm,
                                    Portland, Oregon

Class II (Nominees for Terms of Office to Expire in 2002):

Andrew S. Goldstein                 Senior Vice President of Advanced           50               1981
                                    Technology Development of the
                                    Company

G. Patrick Sheaffer                 Chairman, President and Chief               59               1983
                                    Executive Officer of Riverview
                                    Savings Bank, Camas, Washington

Robert J. Zollars                   Executive Vice President and Group          41               1998
                                    President of Cardinal Health, Inc., a
                                    pharmaceutical service provider,
                                    Dublin, Ohio

Class III  (Directors Whose Terms of Office Expire in 2001):

Margaret H. Jordan                  President of The Margaret Jordan            56               1995
                                    Group, L.L.C., a management consulting
                                    firm for the health care organization
                                    industry, Addison, Texas

Michael J. Paxton                   President of First Alert, a manufacturer    52              1995
                                    and distributor of residential safety
                                    equipment, Aurora, Illinois
</TABLE>

         W.  Charles  Armstrong,  now a  private  investor,  served  as  interim
President  and Chief  Executive  Officer of the Company from May 1997 to October
1997. He was Chairman and Chief Executive Officer of Bank of America Oregon from
September  1992 until  September  1996.  From April to  September  1992,  he was
Chairman and Chief  Executive  Officer of Bank of America Idaho.  Mr.  Armstrong
served as President and Chief Operating Officer of Honolulu Federal Savings Bank
from February 1989 to April 1992.  Prior to February  1989, he was President and
Chief  Executive  Officer of West One Bank,  Oregon.  He is also a  director  of
Agritope,  Inc.,  which was a  subsidiary  of the Company  until its spin-off in
December 1997.

4
<PAGE>

         Andrew S. Goldstein is Senior Vice President of the Company, a position
he has held since June 1990.  Prior to that time, he had been Vice  President of
Product  Development  from December 1988,  Vice President of Scientific  Affairs
from July 1987 to December 1988, and Vice President of Research and  Development
from 1981 until July 1987. He also has served as Secretary from December 1988 to
February  1993 and from  November  1995 to the present  and served as  Treasurer
until March 1991.  Mr.  Goldstein was Research  Associate and  supervisor of the
Histocompatibility Laboratory at the Oregon Health Sciences University ("OHSU"),
where he was engaged in paternity testing and transplantation  immunology,  from
1974 to 1981. Mr. Goldstein  received a B.S. degree in microbiology from Cornell
University  in 1969 and a M.S.  degree in cytology  from Fordham  University  in
1973.

         Margaret H. Jordan has been  President  of The Margaret  Jordan  Group,
L.L.C.,  since  October  1997.  Prior to that time,  she was President and Chief
Executive  Officer of Dallas Medical Resource ("DMR") from February 1996. DMR is
a  not-for-profit  alliance  of Dallas'  major  medical  organizations  that was
created to make Dallas, Texas, a regional, national and international center for
medical  referrals.  Ms.  Jordan was Vice  President  of Health  Care & Employee
Services at Southern  California  Edison Co. from  December  1992 until  January
1996.  She had previously  been a Vice  President and Regional  Manager with the
Kaiser  Foundation  Health Plan of Texas,  Inc.,  beginning in 1986,  and was an
Associate  Regional Manager of Kaiser Foundation  Health Plan of Georgia,  Inc.,
from 1984 to 1986. Ms. Jordan  received a B.S. degree in Nursing from Georgetown
University in 1964 and an M.S.  degree in Public  Health from the  University of
California,  Berkeley  in 1972.  She also  serves on the Board of  Directors  of
Eckerd Corporation.

         John W. Morgan has been  President and Chief  Executive  Officer of the
Company   since   October   1997.   Before   joining   the   Company,   he   was
President-Americas  of Regent Medical  Products Group,  Norcross,  Georgia since
1996. Prior to joining Regent,  he held various positions with Baxter Healthcare
Corporation,  where he worked for 13 years. From 1993 to 1996, he was President,
Mid-America  Regional  Company of Baxter.  Mr. Morgan  received a B.S. degree in
Public  Administration and Economics from the University of Arizona in 1982. Mr.
Morgan  also  serves  on  the  board  of  directors  of  Koch  Supply,  Inc.,  a
manufacturer and distributor for the red meat and poultry industry.

         Michael J.  Paxton  became  President  of First  Alert,  a division  of
Sunbeam Corporation,  in August 1998. He was previously Chairman,  President and
Chief Executive  Officer of O'Cedar Holdings,  Inc.,  beginning in January 1996.
From March 1992 until joining O'Cedar Holdings, Inc., he was President and Chief
Executive  Officer  of The  Haagen-Dazs  Company,  Inc.  Prior  to  that  he was
President of the Baked Goods Division of The Pillsbury  Company.  Both companies
are subsidiaries of Grand  Metropolitan  PLC. He is also a director of Transport
Corporation of America, Inc.

         Roger L.  Pringle has been  Chairman of the Board of the Company  since
April 1990. He is President of The Pringle Company, a management consulting firm
in Portland, Oregon, which he founded in 1975. Mr. Pringle is also a director of
Agritope, Inc., and Bank of the Northwest.

         G.  Patrick  Sheaffer has been  President of Riverview  Savings Bank in
Camas,  Washington,  since 1979,  and has served as a director of the bank since
1983. In 1993, Mr. Sheaffer also became Chairman and Chief Executive  Officer of
Riverview  Savings Bank and Riverview  Mutual  Holding  Company,  a bank holding
company. He has been a director of the Washington Savings League since 1980.

         Robert J. Zollars has been Executive Vice President and Group President
of Cardinal Health,  Inc.,  Dublin,  Ohio, since January 1997. Prior to that, he
served as Group Vice President of Allegiance  Corporation since October 1996 and
was previously a corporate officer of Baxter Healthcare,  Inc., most recently as
President,  U.S.  Distribution.  Mr.  Zollars has nearly 20 years of health care
industry experience.


D I R E C T O R S'   M E E T I N G S

         The Board held 12 meetings  during the fiscal year ended  September 30,
1998.  Each of the directors  listed above  attended more than 75 percent of the
combined  total of meetings of the Board and of committees of the Board

                                                                               5
<PAGE>

on which the  director  served  during the year,  except  Michael J.  Paxton and
Robert J. Zollars, who attended 64 percent and 71 percent,  respectively, of the
combined total of meetings.

C O M M I T T E E S   O F   T H E   B O A R D

         The  Board  has  designated  an  Executive  Committee  to assist in the
discharge of the Board's  responsibilities.  The Executive Committee is composed
of four directors,  Roger L. Pringle,  Chairman,  W. Charles Armstrong,  John W.
Morgan and Michael J.  Paxton.  The  Executive  Committee  met twice  during the
fiscal year ended  September 30, 1998. The Executive  Committee may exercise all
the  authority  and powers of the Board in the  management  of the  business and
affairs  of the  Company,  except  those  reserved  to the  Board by the  Oregon
Business Corporation Act or the Company's bylaws.

         The  Executive  Compensation  Committee  of the Board  establishes  and
reviews from time to time  compensation  for executive  officers of the Company,
administers the Company's Incentive Stock Option Plan for Key Employees ("ISOP")
and 1991 Stock Award Plan (the  "Plan"),  and performs  other tasks as the Board
may direct.  Members of the  Executive  Compensation  Committee  are W.  Charles
Armstrong, Chairman, G. Patrick Sheaffer, and Robert J. Zollars, none of whom is
eligible  to  participate  in the  Company's  compensation  plans  other than to
receive options awarded to nonemployee  directors of the Company pursuant to the
Plan.   See   EXECUTIVE   COMPENSATION   Compensation   of  Directors  -  Equity
Compensation.  The  Executive  Compensation  Committee met five times during the
fiscal year ended September 30, 1998.

         The  Audit   Committee  of  the  Board  reviews  the   performance  and
independence of the Company's outside  auditors.  Members of the Audit Committee
are G. Patrick Sheaffer, Chairman, and Roger L. Pringle. The Audit Committee met
once during fiscal year 1998 and  recommended  to the Board of Directors that no
change be made with  regard to the  outside  auditors,  and that no  significant
changes in the Company's accounting practices were necessary.

         The Nominating Committee of the Board solicits and recommends potential
candidates  for  membership  on the  Board  of  Directors.  The  members  of the
Nominating  Committee  are Roger L.  Pringle,  Chairman,  Andrew  S.  Goldstein,
Margaret H. Jordan and John W. Morgan.  The Nominating  Committee met four times
during  fiscal year 1998,  recommending  Robert J.  Zollars for  election to the
Board of Directors and  reporting on progress in selecting  candidates to fill a
vacancy on the Board.

         The  Nominating   Committee  will  consider  nominees   recommended  by
shareholders. Shareholders wishing to recommend a candidate for consideration by
the  Nominating  Committee  should  submit  information  about the  candidate in
writing to the Company at the address and by the deadline  stated under DEADLINE
FOR SHAREHOLDER PROPOSALS.

         The Company's Bylaws provide that nominations for election to the Board
may be made by the Board or by any shareholder entitled to vote for the election
of directors. Notice of a shareholder's intent to make such a nomination must be
given in writing,  by personal delivery or certified mail,  postage prepaid,  to
the  Secretary  of the  Company  and must  include  the name and  address of the
shareholder and each proposed nominee, a representation  that the shareholder is
a record  holder of Common  Stock and intends to appear in person or by proxy at
the  shareholder  meeting to  nominate  the person or persons  specified  in the
notice,  a description of any arrangements or  understandings  pursuant to which
the nominations are to be made, the consent of each proposed nominee to serve as
a director if elected,  and such other  information  regarding  each  nominee as
would be required to be included in the Company's proxy statement had the person
been nominated by the Board. Such notice, with respect to an election to be held
at an annual meeting of shareholders,  must be given at least 60 days in advance
of the  anniversary  of the  date  of the  previous  year's  annual  meeting  of
shareholders  or,  with  respect  to  an  election  to  be  held  at  a  special
shareholders  meeting,  must be given no later than the close of business on the
seventh day  following  the date on which notice of such meeting was first given
to shareholders.

6
<PAGE>

                               EXECUTIVE OFFICERS

         The table below gives information about the current executive  officers
of the Company.


<TABLE>
     Name                                            Age                                Position
- -------------------------------------------------------------------------------------------------------------------

<S>                                                  <C>                        <C>
John W. Morgan                                       39                         President, Chief Executive
                                                                                Officer,         and Director

Edward V. Collom, Jr.                                51                         Vice President of Sales
                                                                                and Marketing

Charles E. Bergeron                                  53                         Chief Financial Officer

Andrew S. Goldstein                                  50                         Senior Vice President of
                                                                                Advanced Technology
                                                                                Development, Secretary
                                                                                and Director

J. Richard George, Ph.D.                             57                         Chief Scientific Officer
</TABLE>


Officers of the Company hold office at the discretion of the Board.

For  biographical  summaries of Mr.  Morgan and Mr.  Goldstein,  see ELECTION OF
DIRECTORS.

         Edward V. Collom,  Jr., has been Vice  President of Sales and Marketing
since March 1998. Prior to accepting employment with the Company, Mr. Collom was
Vice President, Business Development with responsibility for sales and marketing
of forensic drug testing services and  drugs-of-abuse and on-site drug screening
devices at PharmChem  Laboratories,  Menlo Park,  California,  since March 1996.
From 1993 to February  1996,  Mr.  Collom was the  Business  Unit  Director  for
Microgenics/Boehringer  Mannheim's  Immunoassay Unit. Mr. Collom has also worked
with Specialty  Laboratories,  Johnson & Johnson - Ortho  Diagnostics and DuPont
Medical Products,  where he gained experience with HIV,  hepatitis,  and Western
blot products.

         Charles E.  Bergeron  has been Chief  Financial  Officer of the Company
since January 1998. He has served as Chief  Financial  Officer - Epitope Medical
Products  since  September  1997,  and has been Vice  President of  Operations -
Epitope  Medical  Products since July 1995. Mr.  Bergeron  joined the Company in
August 1993 as President and Chief Executive  Officer,  Agrimax Floral Products,
Inc., then a wholly-owned subsidiary. From 1978 to 1992, Mr. Bergeron was Senior
Vice President - Finance of Freightliner Corporation,  a Portland, Oregon, truck
manufacturer.  He holds a B.S. degree in Management Engineering,  an M.S. degree
in Management Science from Rensselaer  Polytechnic  Institute,  and a Masters of
Business Administration degree from Columbia University.

         J. Richard  George,  Ph.D.,  has been Chief  Scientific  Officer of the
Company  since  January  1998.  He  joined  the  Company  as Vice  President  of
Scientific Affairs - Epitope Medical Products in March 1995. A career scientist,
Dr.  George  previously  served the Centers for Disease  Control and  Prevention
("CDC"),  Atlanta,  Georgia,  which  he  joined  in 1960.  He held a  series  of
management and technical  positions at the CDC,  becoming  Chief,  Developmental
Technology,  Laboratory  Investigations Branch, Division of HIV/AIDS in 1988. He
holds B.S.  and M.S.  degrees  from  Georgia  State  University  and a Ph.D.  in
microbiology from the University of Georgia.

                                                                               7
<PAGE>

                             EXECUTIVE COMPENSATION

S U M M A R Y   C O M P E N S A T I O N   T A B L E

         The following table  summarizes the compensation of all individuals who
served as Chief  Executive  Officer  during  fiscal year 1998 and the four other
most highly  compensated  individuals who were serving as executive  officers of
the Company at September 30, 1998.
<TABLE>
                                                                                 Long-Term
                                                                                Compensation
                                           Annual Compensation                     Awards   
                                           -------------------                  ------------

                                                                                Securities
                                                                                Underlying       All Other
Name and Principal Position          Year      Salary         Bonus             Options(#)(1)    Compensation(2)
- -------------------------------------------------------------------------------------------------------------------

<S>                                  <C>      <C>           <C>                   <C>              <C>       
John W. Morgan    (3)                1998     $238,404            -               350,000          $61,071(4)
President and Chief
Executive Officer

W. Charles Armstrong (3)             1997            -            -                30,000(5)            -
Interim President and
Chief Executive Officer

Edward V. Collom, Jr. (6)            1998       77,000            -                75,000           39,557(4)
Vice President of Sales
and Marketing

Charles E. Bergeron                  1998      150,129            -                30,000                -
Chief Financial Officer              1997      129,567            -               134,000(5)             -
                                     1996      118,990      $15,000                     -                -

Andrew S. Goldstein                  1998      150,000            -                25,000            3,653
Senior Vice President of             1997      149,163            -                94,000(5)         3,750
Advanced Technology                  1996      128,510       30,000                     -            3,206
Development

J. Richard George, Ph.D.             1998      130,000            -                30,000            2,406
Chief Scientific Officer             1997      128,654            -                70,000(5)         3,250
                                     1996       95,192            -                     -            2,329
</TABLE>


(1)      Represents  the number of shares for which  options  were  awarded.  No
         stock  appreciation  rights  ("SARs")  have been  granted  to any named
         executive officer during the years presented.

(2)      Except as otherwise noted in (4) below,  represents amounts contributed
         to the  Company's  401(k)  Profit  Sharing  Plan as  employer  matching
         contributions in the form of Common Stock.

(3)      Mr. Morgan joined the Company in October 1997. Mr.  Armstrong served as
         Interim  President  and Chief  Executive  Officer of the Company  until
         October 6, 1997, but did not receive any  compensation as an officer of
         the Company during fiscal 1998.

8
<PAGE>

(4)      Includes $57,488 and $37,291 in relocation  expenses for Mr. Morgan and
         Mr. Collom,  respectively,  reimbursed by the Company, including moving
         costs, realtor fees, closing costs,  furniture storage costs, and other
         miscellaneous expenses.

(5)      Option grants during fiscal year 1997 consisted of replacement  options
         granted to effect the repricing of outstanding  options,  except for an
         option to purchase 15,000 shares granted to Mr. Armstrong.

(6) Mr. Collom joined the Company in March 1998.


O P T I O N   G R A N T S   I N   L A S T   F I S C A L   Y E A R

<TABLE>
                                               Individual Grants (1)                     
                            -------------------------------------------------------------
                                                                                           Potential Realizable Value at Assumed
                                                                                               Annual Rates of Stock Price
                                                                                             Appreciation for Option Term (2)
                                           Percent of                                      -------------------------------------
                                              Total
                             Number of       Options                 Market
                             Securities     Granted to                Price
                             Underlying     Employees    Exercise    on Date    Expir-
                              Options       in Fiscal    Price Per     of        atio
          Name                Granted          Year        Share      Grant      Date        0%           5%            10%
- -------------------------------------------------------------------------------------------------------------------------------
<S>                           <C>                <C>          <C>       <C>      <C>       <C>          <C>          <C>       
John W. Morgan                350,000 (3)        11.04%       $3.16     $4.72    10/6/07   $546,560     $1,585,080   $3,178,630

Edward V. Collom, Jr.              75,000         2.37%        6.31      6.31     3/9/08          -        297,713      754,538

Charles E. Bergeron            30,000 (3)          .95%        4.72      4.72     1/1/08          -         89,016      225,606

Andrew S. Goldstein                25,000          .79%        6.00      6.00     2/9/08          -         94,325      239,050

J. Richard George              30,000 (3)          .95%        4.72      4.72     1/1/08          -         89,016      225,606
</TABLE>


(1)      Options shown are nonqualified  options with terms of ten years. Except
         as otherwise noted in (3) below, options vest as to one-fourth one year
         after the date of grant,  with the remaining  three-fourths  vesting in
         monthly  installments  over the following 36 months.  Vesting ceases 90
         days following  termination of employment and is accelerated in case of
         a change in control of the Company.  The holder's right to exercise the
         options will terminate  immediately  upon the termination of employment
         for cause, will expire five years after retirement, and will expire one
         year after death,  disability,  or ceasing to be an active  employee of
         the Company for any other reason.  Subject to certain  conditions,  the
         exercise  price of the options  may be paid by  delivery of  previously
         acquired  shares of Common  Stock.  No SARs were granted  during fiscal
         1998.

(2)      The amounts shown are hypothetical gains based on the indicated assumed
         rates of  appreciation  of the Common Stock  compounded  annually for a
         ten-year  period.  There can be no assurance that the Common Stock will
         appreciate at any particular rate or at all in future years.

(3)      Vests as to  one-third  one year  after  the  date of  grant,  with the
         remaining two-thirds vesting in monthly installments over the following
         24  months.  Vesting  continues  for  one  year  after  termination  of
         employment  without cause.  Mr. Morgan may exercise his option prior to
         vesting   under  an  agreement   giving  the  Company  an  option  upon
         termination  of Mr.  Morgan's  employment to repurchase  any shares for
         which the option has been  exercised  but as to which the option is not
         vested at the termination date.

                                                                               9
<PAGE>

F I S C A L   Y E A R - E N D   O P T I O N   V A L U E S  (1)

<TABLE>
                                        Number of Securities Underlying           Value of Unexercised In-the-
                                         Unexercised Options at Fiscal             Money Options at Fiscal Year-
                                                    Year-End                                  End (2)
                                       -----------------------------------       ------------------------------------
                Name                      Exercisable      Unexercisable             Exercisable      Unexercisable
- ---------------------------------------------------------------------------------------------------------------------
<S>                                           <C>                 <C>                           <C>         <C>     
John  W. Morgan                                      -            350,000                        -          $229,355
Edward V. Collom, Jr.                                -             75,000                        -                 -
Charles E. Bergeron                            134,000             30,000                        -                 -
Andrew S. Goldstein                            194,000             25,000                        -                 -
J. Richard George                               47,500             52,500                        -                 -
</TABLE>

(1)      The named  executive  officers  neither  exercised  any options or SARs
         during fiscal 1998 nor held any SARs at September 30, 1998.

(2)      In-the-money  stock options are options for which the exercise price is
         less than the  market  value of the  underlying  stock on a  particular
         date. The values shown in the table are based on the difference between
         $3.81,  which was the  average of the high and low sales  prices of the
         Common  Stock as quoted on The Nasdaq  Stock  Market on  September  30,
         1998, and the applicable exercise price.

E M P L O Y M E N T   A G R E E M E N T S

         Pursuant to written employment agreements with the Company, all current
executive  officers  are  entitled to receive one year of salary in the event of
termination  without  cause  (two  years  in  the  case  of  Mr.  Goldstein  for
termination  in  connection  with a  change  in  control  of the  Company).  The
agreements  with Messrs.  Morgan,  Bergeron,  and Collom  permit them to treat a
change in control and certain other events as a termination  without cause.  The
agreements with Messrs. Morgan, Bergeron and Goldstein in each case prohibit the
officer from  competing with the Company for one year after  termination  unless
the  officer  elects  to waive  the  right to  amounts  otherwise  payable.  The
agreements  with each of Mr.  Collom and Dr.  George  make any  post-termination
payment  contingent  on his  refraining  from  competing  with the Company.  The
agreements  do not expire by their terms and are  terminable by the Company with
cause  (upon 90 days'  notice,  in the case of Mr.  Goldstein)  or,  subject  to
payment of the salary amounts described above, without cause.

C O M P E N S A T I O N   O F   D I R E C T O R S

         Under the Company's 1991 Stock Award Plan, nonemployee directors of the
Company are eligible to receive  nonqualified  stock options.  Such options have
been granted to nonemployee  directors on the basis described  below.  The Board
may decide to grant options on other terms and in other amounts at any time.

         Initial  Options.  Each person who becomes a  nonemployee  director has
been  granted  a stock  option to  purchase  50,000  shares of Common  Stock (an
"Initial  Option").  A newly-elected  Chairman of the Board has been entitled to
receive an Initial Option to purchase an additional 25,000 shares (75,000 shares
if not  previously a nonemployee  director).  Initial  Options are granted at an
exercise  price equal to the fair  market  value of a share on the date of grant
minus the lesser of (a) $2.00 or (b) 25 percent of such fair market value.  Each
Initial Option becomes  exercisable in annual  installments based upon continued
service  as a  director  and  expires  at the end of five  years  following  the
director's retirement or one year following the director's death,  disability or
cessation of service as a director for any other reason.  An Initial Option will
generally  become fully  exercisable by the date of the fourth annual meeting of
shareholders through which the director has served on the Board. Initial Options
become

10
<PAGE>
exercisable  in full  immediately  upon the occurrence of a change in control of
the Company.  A change in control of the Company would occur on the happening of
such events as the  beneficial  ownership  by a person or group of 30 percent or
more of the  outstanding  Common  Stock,  certain  changes  in Board  membership
affecting a majority of positions, certain mergers or consolidations,  a sale or
other transfer of all or substantially  all the Company's assets, or approval by
the shareholders of a plan of liquidation or dissolution of the Company, as well
as any change in control  required to be reported by the proxy  disclosure rules
of the Commission.

         Payment of the  exercise  price may be made in cash or by  delivery  of
previously  acquired  shares of Common Stock having a fair market value equal to
the aggregate  exercise  price. To the extent that payment is made in previously
acquired shares, the director is automatically granted a replacement  ("reload")
option for a number of shares equal to the number  delivered  upon exercise with
an exercise  price equal to the fair market  value of a share of Common Stock on
the date of exercise. Reload options become exercisable in full six months after
the grant date.

         Renewal  Options.  Additional  nonqualified  stock  options  have  been
granted to each  nonemployee  director to purchase 15,000 shares of Common Stock
("Renewal  Options")  as of the  December  15 prior  to the  annual  meeting  of
shareholders  at which the options  most  recently  granted to such  nonemployee
director  fully vest.  Renewal  Options vest in three equal annual  installments
beginning with the second annual meeting of  shareholders  following the date of
grant,  subject to  acceleration  of vesting upon the  occurrence of a change in
control of the Company.  The other terms of Renewal  Options are  comparable  to
those of Initial Options,  except that Renewal Options do not provide for reload
options.


                 REPORT OF THE EXECUTIVE COMPENSATION COMMITTEE

         The  following  report of the Executive  Compensation  Committee of the
Board (the "Committee") shall not be deemed to be incorporated by reference into
any  previous  filing by the Company  under  either the  Securities  Act of 1933
("Securities Act") or the Securities  Exchange Act of 1934 ("Exchange Act") that
incorporates  future  Securities Act or Exchange Act filings in whole or in part
by reference.

         GENERAL. The Committee,  which is composed of independent,  nonemployee
directors,  is responsible  for  establishing  and  administering  the Company's
policies that govern executive compensation and benefit practices. The Committee
evaluates the performance of the executive officers and determines their salary,
merit cash bonus and related benefits.  The Committee also grants certain awards
under the Company's stock option plan.

         COMPENSATION PHILOSOPHY.  The Company's executive compensation programs
are  designed  to (i) align  the  interests  of  executive  management  with the
long-term  interests of the  shareholders,  (ii) motivate Company  executives to
achieve  the  strategic  business  goals  of the  Company  and  recognize  their
individual contributions, and (iii) provide compensation opportunities which are
competitive with those offered by other national biotechnology companies similar
in size and  performance  to the Company.  In  furtherance  of these goals,  the
components of executive  compensation  include base salary,  merit cash bonuses,
stock option grants and other benefits and are linked to individual performance.

         BASE SALARY.  At least annually,  the Committee sets the salary for all
executive   officers.   The   Committee   receives  and   considers   management
recommendations concerning salary adjustments for executive officers, as well as
compensation  data  regarding  other  national  biotechnology   companies.   The
Committee,  based on  management's  recommendation,  did not increase  executive
salaries for fiscal year 1998 other than in connection  with promotions to a new
position.  This action was consistent with management's decision not to increase
wages or salaries for the rest of the Company's employees in fiscal 1998, except
in the case of  promotion,  in order to help  improve  the  Company's  financial
position. Executives promoted during fiscal 1998 were Charles E. Bergeron and J.
Richard George, Ph.D.

         The  Committee  established  the salary level and overall  compensation
package for John W. Morgan, the Company's new Chief Executive Officer,  based on
its  determination  of  the  competitive  requirements  to  attract  a  suitable
candidate  with the  abilities  necessary to assist the Company in achieving its
strategic and financial goals.

                                                                              11
<PAGE>

         MERIT CASH  BONUSES.  No merit cash bonuses were awarded  during fiscal
year 1998.

         STOCK OPTION  GRANTS.  As previously  noted,  an important  goal of the
Company's  compensation  program  is to align  the  interests  of the  executive
officers and other key employees  with the long-term  interests of the Company's
shareholders.  In furtherance  of this goal, the Board of Directors  adopted the
1991 Stock Award Plan pursuant to which the Company may grant stock-based awards
to directors,  officers,  and employees of, and consultants and advisers to, the
Company. The Plan was approved by the shareholders of the Company.

         In general,  the size of individual  option grants is determined by the
Committee  based on the  executive's  duties and the levels of option grants for
executives  with  comparable  positions at other  biotechnology  companies.  The
Committee  does not  consider  the amount and terms of options  already  held by
individual  executive  officers in making new grants.  During  fiscal year 1998,
additional stock options were granted to two executives who were promoted to new
positions  and to Edward V.  Collom,  Jr., who was hired as the  Company's  Vice
President of Sales and  Marketing.  Stock options were also awarded to Andrew S.
Goldstein as part of the Company's  practice of issuing additional options every
three years.  John W. Morgan received stock options as one element of an overall
compensation  package that the Committee  determined was necessary to attract an
executive of the caliber  required for the chief executive  officer  position at
the Company.

         OTHER  COMPENSATION  VEHICLES.  The  Company  also has a 401(k)  Profit
Sharing Plan (the "401(k) Plan") which allows participants to defer compensation
pursuant to Section  401(k) of the Internal  Revenue Code.  All employees of the
Company,  including  executives,  are eligible to participate in the 401(k) Plan
provided  certain   qualifications   are  met.  In  addition  to  amounts  which
participants  may elect to  contribute  to the 401(k)  Plan,  the Company  makes
matching  contributions to the 401(k) Plan in Common Stock of the Company, which
are allocated to all participants.  Payments of benefits accrued for 401(k) Plan
participants  will be made upon  retirement  or upon  termination  of employment
prior to retirement  provided  certain  conditions have been met by the employee
prior to termination.

EXECUTIVE COMPENSATION COMMITTEE:

W. Charles Armstrong, Chairman
G. Patrick Sheaffer
Robert J. Zollars

           COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

         W. Charles Armstrong,  G. Patrick Sheaffer,  Robert J. Zollars,  and R.
Douglas Norby served as members of the Compensation Committee during fiscal year
1998. Mr. Armstrong served as interim  President and Chief Executive  Officer of
the Company from May 1997 to October 6, 1997. He was appointed as chairman and a
member of the Committee after John W. Morgan joined the Company as President and
Chief Executive Officer in October 1997.

                          STOCK PRICE PERFORMANCE GRAPH

         The following graph compares the cumulative  total returns to investors
in the  Company's  Common Stock,  the Standard & Poors 500 Stock Index,  and the
Russell 2000 Index for the period from October 1, 1993,  through  September  30,
1998.  The graph  assumes that $100 was invested on September  30, 1993,  in the
Company's Common Stock and in each of the  above-mentioned  indices and that all
dividends were reinvested.  The Russell 2000 Index is an index of companies with
market capitalizations  similar to the Company. It has been selected because the
Company has been unable to identify a peer group of companies for comparison. No
single  public or private  company has a comparable  mix of  technologies  under
development  or  products  which  serve the same  markets  as the  Company.  The
Company's  management  believes that an index of companies  with similar  market
capitalizations  provides a reasonable  basis for  comparing  total  shareholder
returns.  Shareholders  are  cautioned  that the  graph  shows  the  returns  to
investors  only as of the  dates  noted  and may  not be  representative  of the
returns for any other past or future period.

12
<PAGE>

                 COMPARISON OF FIVE YEAR CUMULATIVE TOTAL RETURN
       AMONG EPITOPE INC., THE S & P 500 INDEX AND THE RUSSELL 2000 INDEX

[GRAPHICAL CHART CONTAINING THE FOLLOWING INFORMATION:

<TABLE>
DATE                      EPITOPE,  INC.                     S&P 500                   RUSSELL 2000
- ----                      ---------------                    -------                   ------------

<S>                        <C>                               <C>                         <C>   
9/93                       $  100                            $  100                      $  100
9/94                           92                               104                         103
9/95                           65                               135                         127
9/96                           65                               162                         143
9/97                           38                               227                         191
9/98                           18                               248                         158]
</TABLE>
















Note: The stock  performance  data for Epitope,  Inc. used to generate the graph
above does not include any adjustment  for the spin-off of the Company's  former
subsidiary,  Agritope,  Inc.,  which was effected as a special stock dividend to
the Company's  shareholders.  In the spin-off, each shareholder of record of the
Company on December 26, 1997, received one share of Agritope, Inc., common stock
for each five shares of Epitope,  Inc.,  common stock.  The closing price of the
Agritope,  Inc.,  common stock on a when-issued basis on The Nasdaq Stock Market
was $8.00 on January 7, 1998, the day before it began trading  independently  of
Epitope, Inc., common stock.

                                                                              13
<PAGE>

                                  ANNUAL REPORT

         The Company's  Annual Report to Shareholders  for the fiscal year ended
September 30, 1998,  accompanies this proxy statement.  On written request,  the
Company will provide,  without charge,  a copy of its Annual Report on Form 10-K
for the  fiscal  year  ended  September  30,  1998,  filed  with the  Commission
(including a list briefly describing the exhibits thereto), to any record holder
or  beneficial  owner of the  Company's  Common Stock on December 15, 1998,  the
record date for the Annual Meeting,  or to any person who  subsequently  becomes
such a record holder or  beneficial  owner.  Requests  should be directed to the
attention  of the  Secretary  of the  Company at the  address of the Company set
forth in the Notice of Annual Meeting of Shareholders immediately preceding this
proxy statement.
                             INDEPENDENT ACCOUNTANTS

         PricewaterhouseCoopers  LLP,  independent public accountants,  examined
the  financial  statements  of  the  Company  for  fiscal  1998.  No  change  in
independent  public  accountants  is  contemplated  for fiscal 1999. The Company
expects  representatives  of  PricewaterhouseCoopers  LLP to be  present  at the
Annual  Meeting and to be available  to respond to  appropriate  questions  from
shareholders.  The accountants  will have the opportunity to make a statement at
the meeting if they desire to do so.

                       DEADLINE FOR SHAREHOLDER PROPOSALS

         Shareholders  of the Company may submit  proposals for inclusion in the
proxy  material for the Company's  Annual  Meeting of  Shareholders  in the year
2000.  Any such  proposals  must  meet the  shareholder  eligibility  and  other
requirements  imposed by rules issued by the  Commission and must be received by
the Company at 8505 S.W. Creekside Place,  Beaverton,  Oregon 97008,  Attention:
Secretary, not later than September 13, 1999.

         The  persons   named  as  proxies  for  the  2000  Annual   Meeting  of
Shareholders will have  discretionary  authority to vote on any matter presented
by a shareholder  for action at such meeting unless the Company  receives notice
of the matter by November  27,  1999,  in which case such  persons will not have
discretionary  voting  authority  except as provided in the  Commission's  rules
governing shareholder proposals.

BY ORDER OF THE BOARD OF DIRECTORS
Andrew S. Goldstein
Secretary
January 11, 1999


14
<PAGE>
PROXY

                                  EPITOPE, INC.
                       1999 ANNUAL MEETING OF SHAREHOLDERS
               PROXY SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS


The undersigned hereby appoints John W. Morgan and Charles E. Bergeron, and each
of them, proxies with full power of substitution to vote all of the shares which
the  undersigned is entitled to vote at the 1999 Annual Meeting of  Shareholders
of Epitope, Inc. (the "Company"),  to be held on Tuesday, February 16, 1999, and
at any further  adjournment  or  adjournments  thereof,  with all the powers the
undersigned  would  possess if personally  present,  with respect to the matters
listed on the reverse side.

THE SHARES  REPRESENTED BY THIS PROXY,  IF PROPERLY  EXECUTED,  WILL BE VOTED AS
SPECIFIED ON THE REVERSE SIDE OR, IF NO SPECIFICATION IS MADE, WILL BE VOTED FOR
THE ELECTION OF THE NOMINEES  LISTED ON THE REVERSE  SIDE AS  directors.  If any
other business  properly comes before the meeting,  the proxies named above will
have  discretionary  authority  to vote  thereon in  accordance  with their best
judgment.

          PLEASE MARK, DATE, SIGN, AND RETURN THE PROXY CARD PROMPTLY.
                  (Continued and to be signed on reverse side.)



                              FOLD AND DETACH HERE




                                  EPITOPE, INC.


                       1999 ANNUAL MEETING OF SHAREHOLDERS

                           TUESDAY, FEBRUARY 16, 1999


                                     - 1 -
<PAGE>

         Please mark your votes as indicated in this example [X]

1.       Election of Directors              FOR          WITHHOLD
         Class II (Term Expiring 2002)      [  ]           [  ]
                  Andrew S. Goldstein
                  G. Patrick Sheaffer
                  Robert J. Zollars

(INSTRUCTION: TO WITHHOLD AUTHORITY TO VOTE FOR ANY INDIVIDUAL NOMINEE, MARK FOR
AND STRIKE A LINE  THROUGH THE  NOMINEE'S  NAME IN THE LIST  ABOVE.  TO WITHHOLD
AUTHORITY TO VOTE FOR ALL NOMINEES, MARK WITHHOLD.)





Signature(s)---------------------------------      Dated: ----------------, 1999

Please date and sign exactly as your name appears on this Proxy.  If signing for
estates,  trusts,  partnerships  or  corporations,  title or capacity  should be
stated. If shares are held jointly, each holder should sign.






                              FOLD AND DETACH HERE




                                  EPITOPE, INC.


                       1999 ANNUAL MEETING OF SHAREHOLDERS

                           TUESDAY, FEBRUARY 16, 1999



                                      -2-



© 2022 IncJournal is not affiliated with or endorsed by the U.S. Securities and Exchange Commission