H&Q HEALTHCARE INVESTORS
497, 1997-02-11
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PROSPECTUS 
                                2,115,336 Shares
                            H&Q HEALTHCARE INVESTORS
 Issuable upon Exercise of Non-Transferable Rights to Subscribe for Such Shares
                       New York Stock Exchange Symbol: HQH


H&Q Healthcare Investors (the "Trust") is issuing to its shareholders of 
record ("Shareholders") as of the close of business on February 7, 1997 (the 
"Record Date"), non-transferable rights (the "Rights") entitling the holders 
thereof to subscribe for an aggregate of 2,115,336 shares of beneficial 
interest of the Trust (the "Shares"), at the rate of one Share for each three 
Rights held (the "Offer"). Shareholders will receive one non-transferable 
Right for each Share held. Shareholders who have fully exercised their Rights 
will have an over-subscription privilege (the "Over-Subscription Privilege") 
to subscribe for additional shares subject to certain limitations and subject 
to allotment, for any Shares not acquired by exercise of primary subscription 
rights. Fractional shares will not be issued upon the exercise of Rights. The 
Rights are non-transferable and will not be admitted for trading on the New 
York Stock Exchange (the "NYSE") or any other exchange. Shares of the Trust 
trade on the NYSE under the symbol "HQH." See "The Offer." THE SUBSCRIPTION 
PRICE PER SHARE WILL BE 95% OF THE LOWER OF (a) THE AVERAGE OF THE LAST 
REPORTED SALES PRICE OF A SHARE ON THE NYSE ON MARCH 5, 1997 (THE "PRICING 
DATE") AND THE FOUR PRECEDING BUSINESS DAYS OR (b) THE NET ASSET VALUE PER 
SHARE (THE "NAV") AS OF THE PRICING DATE. 

THE OFFER WILL EXPIRE AT 5:00 P.M., NEW YORK CITY TIME, ON MARCH 5, 1997 (THE 
"EXPIRATION DATE"). For additional information regarding the Offer, please 
call Shareholder Communications Corporation (the "Information Agent") at 
(800) 733-8481, extension 352, or call collect at (212) 805-7000. 

The Trust is a diversified, closed-end management investment company. The 
Trust's investment objective is to seek long-term capital appreciation by 
investing primarily in securities of companies in the health services and 
medical technology (healthcare) industries ("Healthcare Companies"). The 
Trust will invest primarily in securities of companies that are believed by 
the Trust's investment adviser to have significant potential for 
above-average long-term growth in revenues and earnings. The Trust emphasizes 
investment in securities of emerging growth Healthcare Companies. The Trust 
may also invest up to 40% of its net assets in venture capital or other 
securities subject to legal or contractual restrictions as to resale. Such 
securities may be acquired in connection with venture capital opportunities, 
as well as in private placements in public companies. No assurance can be 
given that the Trust will achieve its investment objective. See "Appendix A-- 
Description of Risk Factors and Investment Techniques." 

The Trust's investment adviser is Hambrecht & Quist Capital Management 
Incorporated, the President and sole Director of which is Alan G. Carr, who 
is responsible for management of the Trust's portfolio. See "Investment 
Adviser." 

The Trust announced the Offer after the close of trading on the NYSE on 
January 3, 1997. The NAV at the close of business on January 3, 1997 and 
February 7, 1997 was $20.46 and $22.50, respectively, and the last reported 
sales price of a Share on the NYSE on those dates was $17.375 and $18.00, 
respectively. 

As a result of the terms of the Offer, Shareholders who do not fully exercise 
their Rights, including the Over-Subscription Privilege described herein, 
will, upon the completion of the Offer, own a smaller proportional interest 
in the Trust than they owned prior to the Offer. The Offer will result in a 
dilution of NAV for all Shareholders, irrespective of whether they exercise 
all or any portion of their rights, because the Subscription Price per Share 
will be less than the then current NAV. Such dilution might be significant. 
See "The Offer." 

   THESE SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE SECURITIES 
    AND EXCHANGE COMMISSION OR ANY STATE SECURITIES COMMISSION NOR HAS THE 
    SECURITIES AND EXCHANGE COMMISSION OR ANY STATE SECURITIES COMMISSION 
         PASSED UPON THE ACCURACY OR ADEQUACY OF THIS PROSPECTUS. ANY 
            REPRESENTATION TO THE CONTRARY IS A CRIMINAL OFFENSE. 


   
- -------------------------------------------------------------------------------
                           Estimated            Estimated     Estimated Proceeds
                     Subscription Price (1)   Sales Load (2)     to Trust (3) 
Per Share                   $17.67               $0.618            $17.052 
Total Maximum (3)        $37,377,987           $1,307,278        $36,070,709 
- ------------------------------------------------------------------------------- 
                                        Footnotes set forth on next page 
- --------------------------------------------------------------------------------

Investors are advised to read this Prospectus and retain it for future 
reference. A Statement of Additional Information dated February 7, 1997 (the 
"SAI") containing additional information about the Trust has been filed with 
the Securities and Exchange Commission and is incorporated by reference in 
its entirety into this Prospectus. A copy of the SAI, the table of contents 
of which appears on page 32 of this Prospectus, may be obtained without 
charge by contacting the Information Agent at (800) 733-8481, extension 352. 
    

                                Dealer Manager 
                      Prudential Securities Incorporated 
February 7, 1997 
<PAGE> 

(Notes from cover page) 


   
(1) Estimated on the basis of the average of the last reported sales price of 
    a Share on the NYSE on February 7, 1997 and the four preceding business 
    days. Pursuant to the Over-Subscription Privilege, the Trust may increase 
    the number of Shares subject to subscription by up to 25% of the Shares 
    offered hereby. If the Trust increases the number of Shares subject to 
    subscription by 25%, the total maximum Estimated Subscription Price will 
    be approximately $46,722,484, the total maximum Estimated Sales Load 
    will be approximately $1,634,098, and the total maximum Estimated 
    Proceeds to the Trust will be approximately $45,088,386. 
    


(2) In connection with the Offer, the Trust has agreed to pay the Dealer 
    Manager (as defined herein) a fee for its financial advisory, marketing 
    and solicitation services equal to 3.50% of the aggregate Subscription 
    Price for the Shares issued pursuant to the Offer and to reimburse the 
    Dealer Manager for out-of-pocket expenses up to $150,000. The Dealer 
    Manager will reallow to certain broker-dealers a concession of 2.25% of 
    the Subscription Price per Share for Shares issued pursuant to the Offer. 
    See "Distribution Arrangements." These fees and expense reimbursements 
    will be borne by the Trust and indirectly by all of the Trust's 
    Shareholders, including those who do not exercise their Rights. The Trust 
    and the Investment Adviser have agreed to indemnify the Dealer Manager 
    against certain liabilities under the Securities Act of 1933, as amended. 



(3) Before deduction of expenses related to the Offer incurred by the Trust, 
    estimated at approximately $368,000, including up to $150,000 to be paid 
    to the Dealer Manager as reimbursement for its out-of-pocket expenses. 



                                      2 
<PAGE> 

                              PROSPECTUS SUMMARY 

   The following summary is qualified in its entirety by reference to the 
more detailed information appearing elsewhere in this Prospectus. Unless 
otherwise indicated, the information in this Prospectus assumes that the 
allowable increase of 25% of the shares of beneficial interest (the "Shares") 
of H&Q Healthcare Investors (the "Trust") offered hereby pursuant to the 
Over-Subscription Privilege (as defined herein) will not occur. 

                                  THE OFFER 


<TABLE>
<CAPTION>
<S>                              <C>
 The Offer                       The Trust is issuing to its shareholders of record 
                                 ("Shareholders") as of the close of business on February 7, 1997 
                                 (the "Record Date") non- transferable rights ("Rights") to 
                                 subscribe for an aggregate of 2,115,336 Shares of the Trust (the 
                                 "Offer"). Each Shareholder will be entitled to subscribe for one 
                                 Share for each three Rights held (the "Primary Subscription"). 

Subscription Price               The subscription price per Share (the "Subscription Price") will 
                                 be 95% of the lower of (a) the average of the last reported sales 
                                 prices of a Share on the New York Stock Exchange ("NYSE") on March 
                                 5, 1997 (the "Pricing Date") and the four preceding business days 
                                 or (b) the net asset value per Share (the "NAV") as of the Pricing 
                                 Date. 

Subscription Period              Rights may be exercised at any time during the subscription period 
                                 (the "Subscription Period"), which commences on February 10, 1997 
                                 and ends at 5:00 p.m. New York City time, on March 5, 1997 (the 
                                 "Expiration Date"). 

Over-Subscription Privilege      Shareholders who fully exercise their Rights in the Primary 
                                 Subscription may have, subject to certain limitations and subject 
                                 to allotment, a privilege to subscribe for additional Shares (the 
                                 "Over-Subscription Privilege"). In order to honor 
                                 over-subscription requests, the Trust may, at its discretion, 
                                 issue up to an additional 25% of the Shares available in the 
                                 Offer. 

Purpose of the Offer             The Investment Adviser (as defined herein) believes that 
                                 increasing the Trust's assets for investment through the Offer 
                                 will benefit the Trust and its Shareholders by better positioning 
                                 the Trust to more fully take advantage of available investment 
                                 opportunities in securities of emerging growth companies in the 
                                 health services and medical technology (healthcare) industries 
                                 ("Healthcare Companies"), particularly venture capital investments 
                                 in biotechnology and other innovative medical technology 
                                 companies. 
                                 While there can be no assurance that such benefits will be 
                                 realized, increasing the Trust's investment assets through the 
                                 Offer is intended to: 
                                 (bullet) allow the Trust to increase its investments at a time 
                                          when the Investment Adviser believes that securities of 
                                          selected biotechnology and other innovative medical 
                                          technology companies are positioned for price 
                                          appreciation due to (i) a substantial number of 
                                          healthcare products awaiting Food and Drug Administration 
                                          ("FDA") approval, (ii) recent advances in computer 
                                          technology and scientific knowledge which have caused a 
                                          proliferation of new healthcare products and which have 
                                          reduced the time and cost of research and development of 
                                          such new products, and (iii) an improved regulatory 
                                          climate; 
</TABLE>


                                      3 
<PAGE> 

                              THE OFFER (Cont'd) 
<TABLE>
   
<CAPTION>
<S>                            <C>
 Purpose of the Offer          (bullet) increase the Trust's average investment size, creating for 
   (Cont'd)                              the Trust additional negotiating leverage and pricing 
                                         influence over venture capital and other private equity 
                                         investments; 

                               (bullet) provide the Trust with the ability to make additional 
                                         investments without realizing capital gains on current 
                                         investments or otherwise selling current investments at an 
                                         unfavorable time; and 
                               (bullet) reduce operating costs per Share. 

                               The Offer affords Shareholders the opportunity to purchase 
                               additional Shares of the Trust at a price that will be below market 
                               value or NAV at the Expiration Date. See "The Offer--Purpose of 
                               the Offer." 

Use of Proceeds                It is expected that the net proceeds of the Offer will be invested 
                               primarily in securities of Healthcare Companies, particularly 
                               venture capital opportunities in biotechnology and other innovative 
                               medical technology companies. See "Use of Proceeds." 

How to Obtain Subscription     Contact your broker, bank or trust company. 
Information                    Contact Shareholder Communications Corporation (the "Information 
                               Agent") toll-free at (800) 733-8481, extension 352, or call collect 
                               at (212) 805-7000. 

How to Subscribe               Shareholders may subscribe in one of the two following ways: 

                               (bullet) Deliver a completed Exercise Form and payment to State 
                                         Street Bank and Trust Company (the "Subscription Agent") 
                                         by the Expiration Date. 
                               (bullet) If your Shares are held in a brokerage, bank or trust 
                                         account, have your broker, bank or trust company deliver a 
                                         Notice of Guaranteed Delivery to the Subscription Agent by 
                                         the Expiration Date. 
</TABLE>
    

                         IMPORTANT DATES TO REMEMBER 


<TABLE>
 <S>                                                             <C>
 Record Date                                                     February 7, 1997 

 Subscription Period                                             February 10, 1997- 
                                                                 March 5, 1997 

 Deadline for delivery of Exercise Form together with payment of 
 Estimated Subscription Price or for delivery of Notice of 
 Guaranteed Delivery                                             March 5, 1997 

 Expiration Date and Pricing Date                                March 5, 1997 

 Deadline for payment of final Subscription Price pursuant to 
 Notice of Guaranteed Delivery                                   March 10, 1997 

 Confirmation Date to Registered Shareholders                    March 18, 1997 

 For Registered Shareholder Purchases--deadline for payment of 
 unpaid balance if final Subscription Price is higher than 
 Estimated Subscription Price                                    April 4, 1997 
</TABLE>


                                      4 
<PAGE> 

                                  THE TRUST 
   
<TABLE>
<CAPTION>
<S>                              <C>
 The Trust                       The Trust is a diversified, closed-end management investment 
                                 company organized as a Massachusetts business trust. As of 
                                 February 7, 1997, the Trust had 6,346,009 Shares outstanding, 
                                 which are traded on the NYSE under the symbol "HQH." As of 
                                 February 7, 1997, the Trust's NAV and last reported sales price 
                                 per Share were $22.50 and $18.00, respectively. 

Investment Adviser               Hambrecht & Quist Capital Management Incorporated (the "Investment 
                                 Adviser") serves as investment adviser to the Trust. The 
                                 Investment Adviser is an indirect wholly-owned subsidiary of 
                                 Hambrecht & Quist Group, which through its various related 
                                 entities has investment research, investment banking and venture 
                                 capital expertise in the healthcare industries. See "Investment 
                                 Adviser." The majority of the Trust's Board of Trustees is 
                                 unaffiliated with the Investment Adviser; nevertheless, the Trust 
                                 may be subject to certain potential conflicts of interest. See 
                                 "Portfolio Transactions and Brokerage." 

Portfolio Manager                Alan G. Carr is the Trust's President and portfolio manager and is 
                                 the President and sole Director of the Investment Adviser. Mr. 
                                 Carr has been managing equity portfolios emphasizing investment in 
                                 emerging growth companies for over 30 years and portfolios 
                                 specializing in publicly traded equity securities of Healthcare 
                                 Companies, as well as in venture capital opportunities in the 
                                 healthcare industries, for the last 15 years. See "Investment 
                                 Adviser" and "Trustees and Officers." 

General Investment Guidelines    The Trust's investment objective is to seek long-term capital 
                                 appreciation by investing primarily in securities of Healthcare 
                                 Companies. Under normal market conditions, the Trust expects to 
                                 invest at least 80% of its net assets in securities of Healthcare 
                                 Companies and in no event will have less than 25% of its net 
                                 assets so invested. 

Venture Capital                  The Trust emphasizes investment in securities of emerging growth 
  Investments                    Healthcare Companies. The Trust may invest up to 40% of its net 
                                 assets in securities subject to legal or contractual restrictions 
                                 as to resale ("Restricted Securities"). The Trust's investments in 
                                 Restricted Securities may include "start-up," early and later 
                                 stage financings of privately held companies and private 
                                 placements in public companies. See "Investment Objective and 
                                 Policies." 
</TABLE>
    

                                      5 
<PAGE> 

                   RISK FACTORS AND SPECIAL CONSIDERATIONS 

   This Prospectus contains certain statements that may be deemed to be 
"forward-looking statements." Actual results could differ materially from 
those projected in the forward-looking statements as a result of 
uncertainties set forth below and elsewhere in the Prospectus. See "Appendix 
A--Description of Risk Factors and Investment Techniques" for a more complete 
description of risks that may be associated with an investment in the Trust. 


<TABLE>
   
<CAPTION>
<S>                             <C>
 Dilution                       The Offer will result in dilution. 
                                As a result of the Offer, Shareholders who do not fully exercise 
                                their Rights will experience dilution of NAV, dilution of a 
                                proportionate ownership interest in the Trust, and dilution of 
                                voting power. 

                                Also, an immediate dilution of NAV will be experienced by all 
                                Shareholders, regardless of whether they exercise any or all of 
                                their Rights, because the Subscription Price will be less than the 
                                current NAV, and the number of Shares outstanding after the Offer 
                                will increase by a greater percentage than the increase in the 
                                size of the Trust's assets. For example, if the assumed 
                                Subscription Price is $19.10, representing a market price which is 
                                only 90% of NAV, assuming that all Rights are exercised, the 
                                Trust's NAV would be reduced by approximately $0.81 per Share or 
                                approximately 3.6% of NAV. However, the actual Subscription Price 
                                may be greater or less than such assumed Subscription Price. The 
                                foregoing example assumes an NAV of $22.33 per Share, based on the 
                                Trust's NAV after the close of trading on Monday, February 3, 
                                1997. 

Concentration in the            The Trust expects under normal market conditions to invest at 
  Healthcare Industries         least 80% of its net assets in securities of Healthcare Companies 
                                and in no event will have less than 25% of its net assets so 
                                invested. Healthcare Companies have in the past been characterized 
                                by limited product focus, rapidly changing technology and 
                                extensive government regulation. These factors may result in 
                                abrupt advances and declines in the securities prices of 
                                particular companies and, in some cases, may have a broad effect 
                                on the prices of securities of companies in particular healthcare 
                                industries. 

                                Intense competition exists within and among certain healthcare 
                                industries, including competition to obtain and sustain 
                                proprietary technology protection upon which Healthcare Companies 
                                can be highly dependent for maintenance of profit margins and 
                                market exclusivity. 

                                Cost containment measures implemented by the federal government 
                                have adversely affected certain sectors of the healthcare 
                                industries. The implementation of any such further cost 
                                containment measures may have an adverse effect on some companies 
                                in the healthcare industries. 

Investment in Emerging          The Trust emphasizes investment in equity securities of emerging 
Growth Companies                growth Healthcare Companies. While these securities offer the 
                                opportunity for significant capital gains, such investments also 
                                involve a degree of risk that can result in substantial losses. 
</TABLE>
    

                                      6 
<PAGE> 

<TABLE>
<CAPTION>
<S>                            <C>
Key Personnel                  There may be only a limited number of securities professionals who 
                               have comparable investment experience to Mr. Carr, the Trust's 
                               portfolio manager, in the area of Healthcare Companies. In the 
                               event of his death, resignation, retirement or inability to act on 
                               behalf of the Investment Adviser, there can be no assurance that a 
                               suitable replacement for Mr. Carr could be found immediately. 

Liquidity of Portfolio         The Trust may invest substantially all of its net assets in 
 Investments                   securities of emerging growth Healthcare Companies, including 
                               venture capital and other private equity investments. Some of 
                               these securities are traded in the over-the-counter market or on 
                               regional stock exchanges where the low trading volume of a 
                               particular security may result in abrupt and erratic price 
                               movements. An investment in such securities may have limited 
                               liquidity, and the Trust may find it necessary to sell at a 
                               discount from recent prices or to sell over extended periods of 
                               time when disposing of such securities. Restricted Securities in 
                               which the Trust may invest cannot be sold except in a public 
                               offering registered under the Securities Act of 1933, as amended 
                               (the "Securities Act"), pursuant to an exemption thereunder or in 
                               compliance with applicable regulations of the Securities and 
                               Exchange Commission. 

Foreign Securities             The Trust may invest up to 20% of its net assets in securities of 
                               foreign issuers, expected to be located primarily in Western 
                               Europe, Canada and Japan, and securities of United States ("U.S.") 
                               issuers traded in foreign markets ("Foreign Securities"). Foreign 
                               Securities may be less liquid and have prices that are more 
                               volatile than securities of comparable U.S. companies. An 
                               investment in Foreign Securities may also involve currency risk. 

Discount from NAV              The Trust's Shares may trade at a discount to NAV. This is a risk 
                               separate and distinct from the risk that the Trust's NAV will 
                               decrease. 

Declaration of Trust           Certain provisions of the Trust's Declaration of Trust may be 
                               regarded as "anti-takeover" provisions because they could have the 
                               effect of limiting the ability of other entities or persons to 
                               acquire control of the Trust. 
</TABLE>


                                      7 
<PAGE> 

                                TRUST EXPENSES 

   The following estimated table is intended to assist Trust investors in 
understanding the various costs and expenses associated with investing in the 
Trust through the exercise of Rights. 

<TABLE>
<S>                                                       <C>
 Shareholder Transaction Expenses 
 Sales Load (as a percentage of the Subscription 
  Price) (1)                                              3.50 % 
 Dividend Reinvestment Plan Fees                          None 
Annual Expenses (as a percentage of average net 
  assets attributable to Shares) (2) 
 Advisory Fee                                             1.375% 
 Other Operating Expenses                                  .225% 
                                                          ----- 
 Total Annual Expenses (3)                                1.600% 
                                                          ===== 
</TABLE>

- ------------- 


(1) In connection with the Offer, the Trust has agreed to pay the Dealer 
    Manager (as defined herein) a fee for its financial advisory, marketing 
    and solicitation services equal to 3.50% of the aggregate Subscription 
    Price for the Shares issued pursuant to the Offer and to reimburse the 
    Dealer Manager for out-of-pocket expenses up to $150,000. The Dealer 
    Manager will reallow to certain broker-dealers a concession of 2.25% of 
    the Subscription Price Per Share for Shares issued pursuant to the Offer. 
    In addition, the Trust has agreed to pay a fee to the Subscription Agent 
    and the Information Agent estimated to be $10,000 and $22,000, 
    respectively, which includes reimbursement for their out-of-pocket 
    expenses related to the Offer. These fees and expenses will be borne by 
    the Trust and indirectly by all of the Trust's Shareholders, including 
    those who do not exercise their Rights. See "Distribution Arrangements." 


(2) Fees payable under the Advisory Agreement (as defined herein) are 
    calculated on the basis of the Trust's total assets. The advisory fee 
    shown above assumes the maximum allowable advisory fee under the Advisory 
    Agreement. "Other Expenses" has been estimated for the current fiscal 
    year. 


   
(3) The estimated 1.60% expense ratio assumes that the Offer is fully 
    subscribed, yielding estimated net proceeds of approximately $36,070,709
    (assuming a Subscription Price of $17.67 per Share) and that, as a 
    result, based on the Trust's net assets attributable to Shareholders on 
    February 7, 1997 of $142,789,123, the net assets attributable to 
    Shareholders would be $178,859,832. 
    


Hypothetical Example 

An investor would directly or indirectly pay the following expense on a 
$1,000 investment in the Trust, assuming a 5% annual return: 

  One Year    Three Years    Five Years    Ten Years 
    $16           $50           $85          $186 


   This hypothetical example assumes that all dividends and other 
distributions are reinvested at NAV and that the percentage amounts listed 
under Annual Expenses above remain the same in the years shown. See also Note 
(3) above for assumptions made in calculating the expenses in this 
hypothetical example. The above tables and the assumption in the hypothetical 
example of a 5% annual return are required by regulation of the Securities 
and Exchange Commission (the "Commission") applicable to all investment 
companies; the assumed 5% annual return is not a prediction of, and does not 
represent, the projected or actual performance of the Trust's Shares. For 
more complete descriptions of certain of the Trust's costs and expenses, see 
"Investment Adviser." 



   This hypothetical example should not be considered a representation of 
past or future expenses, and the Trust's actual expenses may be more or less 
than those shown. 



                                      8 
<PAGE> 

               FINANCIAL HIGHLIGHTS AND INVESTMENT PERFORMANCE 

Financial Highlights 

   The following information has been audited by Arthur Andersen LLP, 
independent public accountants, as stated in their report included elsewhere 
in this Prospectus and should be read in conjunction with the Financial 
Statements and Notes thereto included elsewhere in this Prospectus. 

                           H&Q HEALTHCARE INVESTORS 

                             FINANCIAL HIGHLIGHTS 
  (Selected data for each Share outstanding throughout the period indicated) 

<TABLE>
<CAPTION>
                                                            For the years ended September 30, 
                                          --------------------------------------------------------------------- 
                                              1996          1995          1994          1993          1992 
                                         ------------- ------------- ------------- -------------  ------------- 
<S>                                      <C>           <C>           <C>           <C>            <C>
Net asset value per share: 
 Beginning of period                        $21.818      $ 16.609      $ 17.604      $ 17.340      $ 19.207 
Net investment income (loss)                ($0.331)      ($0.228)      ($0.199)      ($0.190)      ($0.076) 
Net realized and unrealized gain (loss)     
  on investments                              5.487         5.437        (0.230)        0.970         0.247 
Federal income taxes on retained            
  long-term capital gains                        --            --        (0.566)       (0.516)       (1.078)
                                            -------       -------       -------       -------       -------  
                                            
  Total increase (decrease) from            
    investment operations                     $5.156       $5.209       ($0.995)       $0.264       ($0.907) 
                                            -------       -------       -------       -------       -------  
Distribution to shareholders                
 Short-term capital gains                        --            --            --            --       ($0.040) 
 Long-term capital gains                     ($1.220)          --            --            --        (0.920) 
                                            -------       -------       -------       -------       -------  
  Total distributions                        ($1.220)          --            --            --       ($0.960) 
                                            -------       -------       -------       -------       -------  
Net asset value per share:                  
 End of period                               $25.754      $21.818       $16.609       $17.604       $17.340 
                                            ========   ===========   ===========   ===========    =========== 
Per share market value:                   
 End of period                               $20.875       $18.250       $15.125       $18.375       $19.375 
Total investment return (a)                    22.03%        20.66%       (17.69%)       (5.16%)        9.43% 
Net assets: 
 End of period                          $147,552,505  $121,072,675  $92,169,061    $97,690,739   $96,222,175 
RATIOS AND SUPPLEMENTAL DATA: 
Ratio of operating expenses to average 
  net assets                                    1.62%         1.76%         1.74%         1.84%         1.72% 
Ratio of net investment (loss) to 
  average net assets                           (1.44%)       (1.31%)       (1.13%)       (1.06%)       (0.38%) 
Portfolio turnover rate                        22.41%        22.81%        28.10%        28.36%        35.45% 
Average commission rate paid per listed 
  share purchased (a)                           $.07           N/A           N/A           N/A           N/A 
Number of shares outstanding at end of 
  period                                   5,729,160      5,549,198     5,549,198     5,549,198     5,539,450 
</TABLE>


- ------------- 

* Annualized. 

(a) Average commission rate per share required for fiscal years that began 
    September 1, 1995, or later; total investment return information not 
    required for fiscal years 1987 through 1989. 

                                      9 
<PAGE> 

                             FINANCIAL HIGHLIGHTS 
                                 (continued) 

<TABLE>
<CAPTION>
                                                                                             For the period 
                                                                                             April 22, 1987 
                                                                                             (commencement 
                                                                                             of operation) 
                                                                                                   to 
                                                    For the years ended September 30,        September 30, 
                                               -------------------------------------------- 
                                                  1991       1990       1989       1988           1987 
                                               ----------- ---------  --------- -----------  --------------- 
<S>                                           <C>          <C>        <C>       <C>
Net asset value per share: 
 Beginning of period                             $11.313    $10.647     $8.036     $9.450        $9.250 
Net investment income (loss)                     ($0.014)    $0.014     $0.003    ($0.019)       $0.030 
Net realized and unrealized gain (loss) on 
  investments                                      8.743      0.652      2.608     (1.375)        0.170 
Federal income taxes on retained long-term 
  capital gains                                       --         --         --         --            -- 
                                                 --------   --------   --------   --------      -------- 

  Total increase (decrease) from   investment 
  operations                                      $8.729     $0.666     $2.611    ($1.394)       $0.200 
                                                 --------   --------   --------   --------      -------- 
Distribution to shareholders 
 Short-term capital gains                        ($0.055)        --         --         --            -- 
 Long-term capital gains                          (0.780)        --         --    ($0.020)           -- 
                                                 --------   --------   --------   --------      -------- 
  Total distributions                            ($0.835)        --         --    ($0.020)           -- 
                                                 --------   --------   --------   --------      -------- 
Net asset value per share: 
 End of period                                   $19.207    $11.313    $10.647     $8.036        $9.450 
                                               =========== =========  ========= ===========  =============== 
Per share market value: 
 End of period                                   $18.375     $9.250     $9.750     $6.375        $5.625 
Total investment return (a)                       113.06%      1.37%       N/A        N/A           N/A 
Net assets: 
 End of period                                $106,396,527 $62,661,275 $58,974,336 $44,515,399  $52,366,673 
RATIOS AND SUPPLEMENTAL DATA: 
Ratio of operating expenses to average net 
  assets                                            1.73%      1.74%      1.89%      1.98%         1.83%* 
Ratio of net investment (loss) to average net 
  assets                                           (0.10%)     0.12%      0.02%     (0.25%)        0.74%* 
Portfolio turnover rate                            23.04%     47.02%     46.90%     57.42%        17.34%* 
Average commission rate paid per listed share 
  purchased (a)                                      N/A        N/A        N/A        N/A           N/A 
Number of shares outstanding at end of period    5,539,450 5,539,450  5,539,450   5,539,450       5,539,450 
</TABLE>


- ------------- 

* Annualized. 

(a) Average commission rate per share required for fiscal years that began 
    September 1, 1995, or later; total investment return information not 
    required for fiscal years 1987 through 1989. 

                                      10 
<PAGE> 

Portfolio Characteristics 


   A substantial portion of the Trust's investment portfolio consists of 
venture capital and private equity investments. As of December 31, 1996, 
30.7% of the Trust's assets were invested in Restricted Securities of 31 
Healthcare Companies, 16 of which were publicly-traded. The Trust continues 
to value these securities below current market prices as they remain 
restricted as to resale. 



   From inception, the Trust has made 131 venture capital investments in 56 
private companies and 9 private placements in public companies. There have 
been 34 initial public offerings and 3 acquisitions of restricted portfolio 
companies as of December 31, 1996. 



   The following sets forth certain information with respect to the 
composition of the Trust's investment portfolio. 



The Trust's Portfolio 
(as of December 31, 1996) 


The following table sets forth the Trust's ten largest holdings as a 
percentage of net assets. 


                            The Trust's Portfolio 
                          (as of December 31, 1996) 

                     [Tabular representation of bar chart]
 

                                   Restricted  Unrestricted
                  LIQUID ASSETS       0.00%        1.16%  
                  MANAGED CARE        0.00%        4.24%  
                  AGRI/ENVIRO         0.78%        5.46%  
                  PHARMACEUTICALS     0.46%        7.20%  
                  CROs                1.67%        7.77%  
                  DIAGNOSTICS         6.72%        3.62%  
                  MEDICAL SPECIALTY   5.36%        5.82%  
                  MEDICAL SUPPLIES    4.54%        7.61%  
                  BIOTECHNOLOGY      11.14%       26.45%  


   The following table sets forth the Trust's ten largest holdings as a 
percentage of net assets. 


                       The Trust's Ten Largest Holdings 
                          (as of December 31, 1996) 

<TABLE>
<CAPTION>
                                                 % of Net Assets 
                                                  ---------------- 
<S>                                               <C>
Martek Biosciences*                                    6.91% 
Quintiles Transnational                                5.46% 
Vivus*                                                 5.16% 
IBAH*                                                  3.98% 
Cytyc*                                                 3.54% 
IDEXX Laboratories*                                    2.88% 
Vencor                                                 2.79% 
SEQUUS Pharmaceuticals*                                2.76% 
INCYTE Pharmaceuticals                                 2.57% 
Spiros Development*                                    2.54% 
                                                       ------ 
   Total                                               38.59% 

</TABLE>


*These securities were Restricted Securities when initially purchased by the 
 Trust. 

                                      11 
<PAGE> 


As of December 31, 1996, seven of the Trust's ten largest holdings were 
originally venture capital investments. This portion of the Trust's 
investment portfolio has historically outperformed the Trust's overall 
portfolio as measured by NAV total return. Through December 31, 1996, the 
internal rate of return as calculated by the Investment Adviser for the 
restricted portfolio has been 20.3% per year before fees and 18.9% per year 
after allocated advisory fees since inception. The preceding rate of return 
information represents past performance only, was derived during a period of 
generally rising securities prices, and is not a guarantee of future 
performance. Shareholders of the Trust may experience gain or loss as a 
result of the price performance of Shares of the Trust, which in turn is 
materially affected by the performance of the entire portfolio, not just the 
Restricted Securities portion of the portfolio. There can be no guarantee 
that the Investment Adviser will invest the Trust's assets in successful 
Restricted Securities investments. 



Share Price and NAV 


   
   The Trust's Shares are publicly held and have been listed and are trading 
on the NYSE. The average weekly trading volume of the outstanding Shares of 
the Trust for the calendar year ended December 31, 1996 was 77,985. Shares of 
the Trust have frequently traded at a discount to NAV but have occasionally 
traded at a premium to NAV. There can be no assurance that Shares will trade 
at premium to NAV in the future. The following table sets forth for the 
quarters indicated the high and low closing prices per Share on the NYSE, the 
corresponding NAV, the percentage premium or discount at such closing prices, 
and the number of Shares traded. See the cover page of this Prospectus for 
the NAV and the last reported sales price per Share on the NYSE as of the 
date of this Prospectus. 
    



<TABLE>
<CAPTION>
                     Market                                 Market 
                      Price    Corresponding    Premium/    Price    Corresponding    Premium/ 
  Fiscal (Sept.)       (1)       Net Asset     (Discount)    (1)       Net Asset     (Discount)    Trading 
      Quarter         High       Value (2)        (2)        Low       Value (2)         (2)        Volume 
 ------------------  ----------------------- ------------  -------- --------------- ------------ ----------- 
<S>                  <C>     <C>             <C>           <C>      <C>             <C>          <C>
1995 
 First Quarter       $15.25       $16.55          (7.85)%   $12.88       $15.47        (16.77)%     672,800 
 Second Quarter       15.00        16.84         (10.93)     13.38        15.98        (16.30)      561,500 
 Third Quarter        15.63        17.38         (10.10)     13.88        17.01        (18.43)      592,600 
 Fourth Quarter       18.88        21.62         (12.70)     15.25        18.50        (17.57)      674,000 
1996 
 First Quarter        20.50        23.10         (11.26)     16.88        20.37        (17.16)      622,600 
 Second Quarter       23.88        26.24          (9.01)     20.00        23.39        (14.49)      796,600 
 Third Quarter        23.63        28.84         (18.08)     20.25        24.98        (18.94)      711,900 
 Fourth Quarter       21.75        26.77         (18.75)     17.63        21.77        (19.04)      780,900 
1997 
 First Quarter (3)    21.13        26.35         (19.83)     15.88        18.85        (15.78)    1,765,800 
</TABLE>


- ------------- 
(1) As reported by the NYSE. 
(2) Based on the Trust's computations, on the day that the high or low market 
    price was recorded. 
(3) Not adjusted for long-term capital gains distribution of $4.49 per share. 



                                      12 
<PAGE> 

Investment 
Performance 


   Total Return of the Trust. Since the Trust's first full month of 
operations, the Trust's Share price and NAV have increased at an annualized 
rate of 10.7% and 13.0%, respectively, through December 31, 1996. The 
following two charts compare the historical total return of the Trust as 
measured by changes in Share price and NAV, with changes in the Dow Jones 
Medical and Biotechnology Index. The charts reflect the reinvestment of 
dividends and capital gains and do not incorporate shareholder transaction 
costs. 



                      H&Q Healthcare Investors Stock Price
                  v. Dow Jones Medical and Biotechnology Index
                   (from April 30, 1987 to December 31, 1996)


[HQH Stock Price Line Chart]


                     "HQH Stock     "Dow Jones Medical and 
                      Price(1)"     Biotechnology Index(2)"

30-Apr-87               100                100
                        84.6               102.9
                        84.6               99.6
                        89.7               99.1
                        84.6               100.1
30-Sep-87               79.5               98.2
                        61.5               69.9
                        51.3               65.3
                        57.9               77.1
                        63                 79.9
29-Feb-88               68.2               81.8
                        70.7               79.9
                        66.9               70.5
                        65.6               66.9
                        68.2               69.4
31-Jul-88               68.2               65.8
                        64.3               63.3
                        66.9               62.5
                        66.9               61.1
                        60.4               59.2
31-Dec-88               65.6               62.1
                        68.2               66.8
                        65.6               68.1
                        72                 72.9
                        77.2               76.2
31-May-89               79.7               79.3
                        75.9               77.1
                        82.3               83.8
                        82.3               82.9
                        93.9               88.3
31-Oct-89               88.7               92.4
                        96.4               95.7
                        100.3              92
                        95.2               88.1
                        92.6               94
31-Mar-90               97.7               98.3
                        93.9               99.5
                        105.4              114.8
                        118.3              123.4
                        117                108.3
31-Aug-90               101.6              101.9
                        95.2               94
                        96.4               91.5
                        111.9              110.2
                        121.3              109.6
31-Jan-91               126.8              125
                        151.7              150.3
                        177.9              168.7
                        169.6              156.9
                        175.1              170.2
30-Jun-91               166.8              162
                        173.7              178
                        188.9              183.5
                        201.3              197.7
                        224.7              211.3
30-Nov-91               228.9              207.5
                        294.8              246.8
                        309.1              222.5
                        293.3              195.9
                        270.4              181.6
30-Apr-92               227.5              152.8
                        237.5              167.2
                        226.1              165.6
                        257.6              170.2
                        236.1              157.7
30-Sep-92               217.5              151.5
                        224.6              158.1
                        236.1              176.8
                        217.5              178
                        206                149.6
28-Feb-93               207.5              127.2
                        197.5              127.6
                        200.3              124.1
                        206                128.1
                        197.5              132.7
31-Jul-93               193.2              131.6
                        201.8              131.8
                        210.3              141
                        217.5              153.6
                        198.9              153.6
31-Dec-93               200.3              155.8
                        218.9              165.4
                        204.6              150.6
                        193.2              142.2
                        180.3              140.9
31-May-94               180.3              148.5
                        163.1              141.6
                        160.3              149.9
                        178.9              168.6
                        173.1              176.4
31-Oct-94               156                174.5
                        160.3              176.9
                        157.4              179.4
                        164.5              185.1
                        163.1              184.6
31-Mar-95               158.8              186.8
                        166                185.2
                        164.5              183
                        176                193.7
                        190.3              199
31-Aug-95               206                208.6
                        208.9              216.2
                        207.5              213.1
                        207.6              227
                        248.8              254.2
31-Jan-96               276.3              267.6
                        274.8              264.2
                        259.5              259
                        270.2              264.3
                        283.9              263.7
30-Jun-96               264.1              245.6
                        232                236.8
                        247.3              249.2
                        254.9              273.5
                        235.1              271.2
30-Nov-96               252.6              277.1
31-Dec-96               267.8%             281.9%













                    H&Q Healthcare Investors Net Asset Value
                  v. Dow Jones Medical and Biotechnology Index
                   (from April 30, 1987 to December 31, 1996)



[HQH Net Asset Value Line Chart]

                    "HQH Net Asset  "Dow Jones Medical and 
                       Value(1)"    Biotechnology Index(2)"

30-Apr-87               100                100
                        99.5               102.9
                        103                99.6
                        103.1              99.1
                        104.1              100.1
30-Sep-87               100.8              98.2
                        76                 69.9
                        74.7               65.3
                        78.9               77.1
                        84.3               79.9
29-Feb-88               87.2               81.8
                        89.1               79.9
                        87.7               70.5
                        83.8               66.9
                        88.4               69.4
31-Jul-88               87.1               65.8
                        83.7               63.3
                        87.2               62.5
                        86.6               61.1
                        80.2               59.2
31-Dec-88               85.1               62.1
                        88.5               66.8
                        87.9               68.1
                        93.7               72.9
                        97.8               76.2
31-May-89               102.1              79.3
                        95.9               77.1
                        106.2              83.8
                        109.2              82.9
                        115.5              88.3
31-Oct-89               113.5              92.4
                        119.6              95.7
                        121.7              92
                        113.1              88.1
                        113.5              94
31-Mar-90               118                98.3
                        115.9              99.5
                        129.6              114.8
                        138.5              123.4
                        140.9              108.3
31-Aug-90               128.8              101.9
                        122.6              94
                        122.4              91.5
                        134.8              110.2
                        142.9              109.6
31-Jan-91               146.3              125
                        174.6              150.3
                        191                168.7
                        186.4              156.9
                        194.6              170.2
30-Jun-91               182.7              162
                        195.8              178
                        213.6              183.5
                        221.5              197.7
                        230.3              211.3
30-Nov-91               236.2              207.5
                        276.7              246.8
                        285                222.5
                        260                195.9
                        245.2              181.6
30-Apr-92               212.7              152.8
                        230.2              167.2
                        211.4              165.6
                        241.4              170.2
                        224.5              157.7
30-Sep-92               223                151.5
                        216.3              158.1
                        235.3              176.8
                        245.8              178
                        235.5              149.6
28-Feb-93               206.6              127.2
                        200.8              127.6
                        201.7              124.1
                        211.1              128.1
                        207.5              132.7
31-Jul-93               205.7              131.6
                        207.5              131.8
                        212.2              141
                        224.5              153.6
                        224.4              153.6
31-Dec-93               226.2              155.8
                        239.1              165.4
                        225.9              150.6
                        209.2              142.2
                        205.4              140.9
31-May-94               204.5              148.5
                        195.3              141.6
                        190.6              149.9
                        210.1              168.6
                        200.4              176.4
31-Oct-94               195.6              174.5
                        190                176.9
                        189.9              179.4
                        199.4              185.1
                        203.5              184.6
31-Mar-95               206.3              186.8
                        202.6              185.2
                        205.1              183
                        216.7              193.7
                        235.8              199
31-Aug-95               254.6              208.6
                        263.3              216.2
                        263.3              213.1
                        268.4              227
                        303.1              254.2
31-Jan-96               336.7              267.6
                        338.2              264.2
                        339.8              259
                        351.9              264.3
                        368.8              263.7
30-Jun-96               338.8              245.6
                        300.4              236.8
                        315.9              249.2
                        331.5              273.5
                        303.1              271.2
30-Nov-96               318.9              277.1
31-Dec-96               324.5%             281.9%














- ------------- 

- ------------- 
(1) Source: CDA/Weisenberger, reflects reinvestment of dividends. 
(2) Source: IDD Information Services/Tradeline, reflects reinvestment of 
dividends. 




   The preceding tables represent past performance only, were derived during 
a period of generally rising securities prices, and are not a guarantee of 
future performance. 



                                      13 
<PAGE> 

                                  THE OFFER 

Terms of the Offer 


   The Trust is issuing to its Shareholders non-transferable Rights to 
subscribe for an aggregate of 2,115,336 Shares, at the rate of one Share for 
each three Rights held. Shareholders will receive one non-transferable Right 
for each Share held. Rights may be exercised at any time during the 
Subscription Period, which commences on February 10, 1997 and ends at 5:00 
p.m. New York City time, on March 5, 1997. Fractional Shares will not be 
issued upon the exercise of Rights. The Rights are non-transferable. 
Therefore, only the underlying Shares will be listed for trading on the NYSE 
or any other exchange. 



   In addition, any Shareholder who fully exercises all Rights issued to him 
or her is entitled to subscribe for Shares which were not otherwise 
subscribed for by others on the Primary Subscription. For purposes of 
determining the number of Shares a Shareholder may acquire pursuant to the 
Offer, broker-dealers whose Shares are held of record by Cede & Co., Inc. 
("Cede"), nominee for the Depository Trust Company, or by any other 
depository or nominee, will be deemed to be the holders of the Rights that 
are issued to Cede or such other depository or nominee on their behalf. 
Shares acquired pursuant to the Over-Subscription Privilege are subject to 
allotment, which is more fully discussed under "The Offer--Over-Subscription 
Privilege." 



   The Rights will be evidenced by Exercise Forms which will be mailed to 
Shareholders. Rights may be exercised by completing an Exercise Form and 
delivering it, together with payment by means of (i) a check or money order 
or (ii) a Notice of Guaranteed Delivery to the Subscription Agent during the 
Subscription Period. The method by which Rights may be exercised and Shares 
paid for is set forth below in "Exercise of Rights" and "Payment for Shares." 



Purpose of the Offer 


   The Board of Trustees of the Trust (the "Board") has determined that it is 
in the best interests of the Trust and its Shareholders to increase the 
assets of the Trust available for investment through the Offer, so that the 
Trust will be in a better position to more fully take advantage of available 
investment opportunities in Healthcare Companies, particularly venture 
capital investments in biotechnology and other innovative medical technology 
companies. The Board was informed by the Investment Adviser that many high 
quality venture capital investment opportunities were becoming available, and 
that Shareholders could potentially realize significant benefits from 
increased investment in venture capital securities, as well as other 
investments in Healthcare Companies. The Board also reviewed data suggesting 
that increased asset size would favorably affect the Trust's expense ratio. 
The Board unanimously approved the Offer and concluded that increasing the 
assets of the Trust through the Offer would be beneficial to the Trust and 
its Shareholders. However, there can be no assurance that the anticipated 
benefits discussed herein will occur as a result of increasing the assets of 
the Trust through the Offer. In determining that the initiation of the Offer 
and the proposed terms of the Offer were in the best interest of 
Shareholders, the Board considered a variety of factors, including those set 
forth below: 


   Recent Developments in Certain Healthcare Sectors. While the healthcare 
industries as a whole have undergone substantial transformation during the 
past decade thereby creating a degree of investment uncertainty, the 
Investment Adviser believes that recent events in specific industries, 
particularly in the biotechnology and medical technology industries, provide 
the Trust with a significant investment opportunity. Recent advances in 
computer technologies have provided researchers with an ability to 
substantially reduce product research and development costs, thereby 
providing a more efficient means of evaluating the feasibility of a new 
therapeutic product or device. Increased development in the biotechnology and 
medical technology industries has, in part, resulted in an increase in the 
current pipeline of new healthcare products. The Investment Adviser estimates 
that more than 15 therapeutic products for a variety of diseases have 
completed human clinical trials and are awaiting FDA marketing approval, that 
there are approximately 140 products in late stage (Phase III) human clinical 
trials and that over 1,000 products are in earlier stage trials and 
pre-clinical development. Although extensive cost containment measures 
proposed by the U.S. Executive Branch in 1994 failed to win Legislative 
support, cost containment measures remain an active part of both national and 
local legislative agendas. The Investment Adviser believes that Healthcare 
Companies which provide products and services of comparable quality to, but 
at a lower cost than, existing products and services provide favorable 
investment opportunities. The Investment Adviser believes that biotechnology 
and other innovative medical technology companies may be currently valued at 
prices 

                                      14 
<PAGE> 

which do not reflect the prospects for such companies. The Trust will use the 
net proceeds from the Offer to capitalize on such investment opportunities. 

   Increased Investment Size. The Investment Adviser believes that larger 
investments by the Trust provide additional negotiating leverage and pricing 
influence over venture capital and other private equity investments. With an 
increased asset base through the Offer, the Trust will be able to make 
investments of the size necessary to achieve more favorable investment terms. 

   Additional Investments. In order to take advantage of new investment 
opportunities in the healthcare industries without the Offer, the Trust would 
be required to sell a portion of its existing investments which would incur 
transaction costs and may result in a realization of significant capital 
gains or otherwise take place at a time when the investment sold may not have 
fully achieved the Trust's investment objective for it. The Offer provides 
the Trust with the ability to both capitalize on new investment opportunities 
and maintain its investment in existing assets. 

   Opportunity to Purchase Below Market Price and NAV. The Offer affords 
existing Shareholders the opportunity to purchase additional Shares at a 
price that will be below market value and NAV at the Expiration Date. 
However, Shareholders who do not fully exercise their Rights will own, upon 
completion of the Offer, a smaller proportional interest in the Trust than 
they owned prior to the Offer. 

   Reduction in Operating Costs Per Share. The Board was advised by the 
Investment Adviser that the Trust could potentially achieve additional 
economies of scale as a result of an increase in total assets. The Investment 
Adviser believes that the increase in assets from the Offer will reduce the 
Trust's expenses as a percentage of average net assets per Share. 

Over-Subscription Privilege 

   If some Shareholders do not exercise all of the Rights initially issued to 
them in the Primary Subscription, such Shares which have not been subscribed 
for will be offered, by means of the Over-Subscription Privilege, to 
Shareholders who have exercised all the Rights initially issued to them and 
who wish to acquire more than the number of Shares for which the Rights 
issued to them are exercisable. Shareholders who exercise all the Rights 
initially issued to them will be asked to indicate, on the Exercise Form 
which they submit with respect to the exercise of the Rights, how many Shares 
they are willing to acquire pursuant to the Over-Subscription Privilege. The 
Trust may, at its discretion, issue up to an additional 25% of the Shares in 
the Offer to honor over-subscription requests if sufficient Shares are not 
available from the Primary Subscription to honor all over-subscriptions. If 
sufficient Shares remain, all over-subscriptions will be honored in full. If 
sufficient Shares are not available to honor all over- subscriptions, the 
available Shares will be allocated among those who over-subscribe based on 
the number of Rights originally issued to them by the Trust, so that the 
number of Shares issued to Shareholders who subscribe pursuant to the 
Over-Subscription Privilege will generally be in proportion to the number of 
Shares owned by them in the Trust on the Record Date. The allocation process 
may involve a series of allocations in order to assure that the total number 
of Shares available for over-subscriptions is distributed on a pro-rata 
basis. 

The Subscription Price 


   The Subscription Price per Share will be 95% of the lower of (a) the 
average of the last reported sales price of a Share on the NYSE on March 5, 
1997 and the four preceding business days OR (b) the NAV as of the Pricing 
Date. 



   
   The Trust announced the Offer after the close of trading on the NYSE on 
January 3, 1997. The NAV at the close of business on January 3, 1997 and 
February 7, 1997 was $20.46 and $22.50, respectively, and the last reported 
sales price of a Share on such Exchange on those dates was $17.375 and $18.00,
respectively. Since the Expiration Date is the same day as the Pricing Date, 
Shareholders who decide to acquire Shares on the Primary Subscription or 
pursuant to the Over-Subscription Privilege will not know the purchase price 
for such Shares when they make such decision. Information about the Trust's 
NAV may be obtained by calling (800) 451-2597. 
    



                                      15 
<PAGE> 

Expiration of the Offer 

   Rights will expire on the Expiration Date and thereafter may not be 
exercised, unless the Offer is extended. 

   Any extension, termination, or amendment will be followed as promptly as 
practical by announcement thereof, such announcement in the case of an 
extension to be issued no later than 9:00 a.m., New York City time, on the 
next business day following the previously scheduled Expiration Date. The 
Trust will not, unless otherwise obligated by law, have any obligation to 
publish, advertise, or otherwise communicate any such announcement other than 
by making a release to the Dow Jones News Service or such other means of 
announcement as the Trust deems appropriate. 

Subscription Agent 


   The Subscription Agent is State Street Bank and Trust Company, 225 
Franklin Street, Concourse Level, Boston, MA 02110, which will receive, for 
its administrative, processing, invoicing and other services as Subscription 
Agent, a fee estimated to be $10,000, which includes reimbursement for all 
out-of-pocket expenses related to the Offer. The Subscription Agent is also 
the Trust's Custodian, Dividend Paying Agent, Transfer Agent and Registrar 
with respect to the Shares. Shareholder questions or inquiries should be 
directed to State Street Bank and Trust Company, P.O. Box 8200, Boston, MA 
02266-8200, telephone (800) 426-5523. SIGNED EXERCISE FORMS SHOULD BE SENT TO 
STATE STREET BANK AND TRUST COMPANY, by one of the methods described below: 


<TABLE>
   
<CAPTION>
         Exercise Form 
        Delivery Method                  Address/Number 
- -------------------------------  ---------------------------------------------------------- 
<S>                             <C>
By Mail                         State Street Bank and Trust Company 
                                Corporate Reorganization 
                                P.O. Box 9061 
                                Boston, MA 02205-8686 
By Hand                         State Street Bank and Trust Company 
                                225 Franklin Street, Concourse Level 
                                Boston, MA 02110 
                                or 
                                Securities Transfer and Reporting Services
                                55 Broadway, Concourse Level 
                                New York, NY 10006 
By Overnight Courier            State Street Bank and Trust Company 
  or Express Mail               2 Heritage Drive 
                                North Quincy, MA 02171 
                                Attn: Corp. Reorg. 
By Broker-Dealer or other       Shareholders whose Shares are held in a brokerage, bank or trust 
  Nominee                       account may contact their broker or other nominee and instruct 
  (Notice of Guaranteed         them to submit a Notice of Guaranteed Delivery and Payment on 
  Delivery)                     their behalf. 
</TABLE>
    

   Delivery to an address other than as set forth above does not constitute a 
valid delivery. 

Information Agent 


   Any questions or requests for assistance may be directed to the 
Information Agent at its telephone number and address listed below: 



   
                    Shareholder Communications Corporation 
                               17 State Street 
                              New York, NY 10004 
                   Call Toll Free: (800) 733-8481, Ext. 352 
                                      or 
                         Call Collect: (212) 805-7000 
    



                                      16 
<PAGE> 

   The Information Agent will receive a fee estimated to be approximately 
$22,000, which includes reimbursement for all out-of-pocket expenses related 
to the Offer. 

Exercise of Rights 


   Rights may be exercised by completing and signing the reverse side of the 
Exercise Form which accompanies this Prospectus and mailing it in the 
envelope provided, or otherwise delivering the completed and signed Exercise 
Form to the Subscription Agent, together with payment for the Shares as 
described below under "Payment for Shares." Completed Exercise Forms and 
related payments must be received by the Subscription Agent prior to 5:00 
p.m. New York City time on or before the Expiration Date (unless payment is 
effected by means of a Notice of Guaranteed Delivery as described below under 
"Payment for Shares") at the offices of the Subscription Agent at the address 
set forth above. A Shareholder who exercises Rights pursuant to the Primary 
Subscription is hereinafter referred to as an "Exercising Shareholder." 
Rights may also be exercised through an Exercising Shareholder's broker, who 
may charge such Exercising Shareholder a servicing fee. 



   Shareholders who are issued fewer than three Rights or Exercising 
Shareholders who hold fewer than three Rights or who, upon exercising their 
Rights, are left with fewer than three Rights will not be able to exercise 
such Rights to purchase an additional Share, respectively, as described under 
"The Offer--Terms of the Offer and Over-Subscription." In addition, 
Shareholders who are issued fewer than three Rights or for whom there is not 
a current address ("stop mail" accounts) will not be mailed this Prospectus 
or other subscription materials. 


   Exercising Shareholders Who Are Record Owners. Exercising Shareholders may 
choose between either option set forth under "Payment for Shares" below. If 
time is of the essence, option (2) will permit delivery of the Exercise Form 
and payment after the Expiration Date. 

   Investors Whose Shares are Held By A Broker-Dealer or Other Nominee. 
Exercising Shareholders whose Shares are held by a nominee such as a 
broker-dealer, bank or trust company must contact the nominee to exercise 
their Rights. In that case, the nominee will complete the Exercise Form on 
behalf of the Exercising Shareholder and arrange for proper payment by one of 
the methods set forth under "Payment for Shares" below. 

   Nominees. Nominees who hold Shares for the account of others should notify 
the respective beneficial owners of such Shares as soon as possible to 
ascertain such beneficial owners' intentions and to obtain instructions with 
respect to exercising the Rights. If the beneficial owner so instructs, the 
nominee should complete the Exercise Form and submit it to the Subscription 
Agent with the proper payment described under "Payment for Shares" below. 

   All questions as to the validity, form, eligibility (including times of 
receipt and matters pertaining to beneficial ownership) and the acceptance of 
subscription forms and the Subscription Price will be determined by the 
Trust, which determinations will be final and binding. No alternative, 
conditional or contingent subscriptions will be accepted. The Trust reserves 
the absolute right to reject any or all subscriptions not properly submitted 
or the acceptance of which would, in the opinion of the Trust's counsel, be 
unlawful. The Trust also reserves the right to waive any irregularities or 
conditions, and the Trust's interpretations of the terms and conditions of 
the Offer shall be final and binding. Any irregularities in connection with 
subscriptions must be cured within such time as the Trust shall determine 
unless waived. Neither the Trust nor the Subscription Agent shall be under 
any duty to give notification of defects in such subscriptions or incur any 
liability for failure to give such notification. Subscriptions will not be 
deemed to have been made until such irregularities have been cured or waived. 

Payment for Shares 

   Exercising Shareholders may exercise their Rights and pay for Shares 
subscribed for pursuant to the Primary Subscription and Over-Subscription 
Privilege in one of the following ways: 


   
  (1) Deliver Exercise Form and Payment to the Subscription Agent by the 
  Expiration Date: 
   Exercising Shareholders may deliver to the Subscription Agent at any of 
the offices set forth above on page 16 (i) a completed and executed Exercise 
Form indicating the number of Rights they have been issued and the number of 
Shares they are acquiring pursuant to the Primary Subscription, as well as 
the number of any additional Shares they would like to subscribe for under 
the Over-Subscription Privilege and (ii) payment for all such ordered Shares 
based on the Estimated Subscription Price of $17.67 per Share, both no 
later than 5:00 p.m., New York City time, on the Expiration Date. 
    



                                      17 
<PAGE> 

   The Subscription Agent will deposit all checks received by it for the 
purchase of Shares into a segregated interest bearing account of the Trust 
(the interest from which will belong to the Trust) pending proration and 
distribution of Shares. 

   A PAYMENT PURSUANT TO THIS METHOD (1) MUST BE IN U.S. DOLLARS BY MONEY 
ORDER OR CHECK DRAWN ON A BANK LOCATED IN THE U.S., (2) MUST BE PAYABLE TO 
"H&Q HEALTHCARE INVESTORS" AND (3) MUST ACCOMPANY AN EXECUTED EXERCISE FORM 
FOR SUCH SUBSCRIPTION TO BE ACCEPTED. THIRD (OR MULTIPLE) PARTY CHECKS WILL 
NOT BE ACCEPTED. 


  (2) Contact Your Broker, Bank or Trust Company to Deliver Notice of 
  Guaranteed Delivery to the Subscription Agent by the Expiration Date: 
   Exercising Shareholders may request a NYSE or National Association of 
Securities Dealers, Inc. member, bank or trust company (each a "nominee") to 
execute a Notice of Guaranteed Delivery (or equivalent electronic 
information) and deliver it, by facsimile or otherwise, to the Subscription 
Agent by 5:00 p.m., New York City time, on the Expiration Date indicating (i) 
the number of Rights they wish to exercise, the number of Primary 
Subscription Shares they wish to acquire, and the number of Over-Subscription 
Privilege Shares for which they wish to subscribe and (ii) guaranteeing 
delivery of payment and a completed Exercise Form from such Exercising 
Shareholder by March 10, 1997. Exercising Shareholders must arrange for 
payment to the nominee, who will in turn submit the Exercise Form and payment 
on their behalf by March 5, 1997. The Subscription Agent will not honor a 
Notice of Guaranteed Delivery unless the completed Exercise Form and full 
payment are received by March 10, 1997. 



   On March 18, 1997 (the "Confirmation Date"), the Subscription Agent will 
send a confirmation to each Exercising Shareholder (or, if the Shares are 
held by a depository or other nominee, to such depository or other nominee), 
showing (i) the number of Shares acquired pursuant to the Primary 
Subscription, (ii) the number of Shares, if any, acquired pursuant to the 
Over-Subscription Privilege, (iii) the per Share and total purchase price for 
the Shares, and (iv) any additional amount payable by such Exercising 
Shareholder to the Trust or any excess to be refunded by the Trust to such 
Exercising Shareholder in each case based upon the final Subscription Price. 
Any additional payment required from an Exercising Shareholder must be 
received by the Subscription Agent by April 4, 1997 (the "Final Payment 
Date"). Any excess payment to be refunded by the Trust to an Exercising 
Shareholder will be mailed by the Subscription Agent to the holder as 
promptly as practicable after the Final Payment Date. 


   Issuance and delivery of certificates for the Shares purchased are subject 
to actual collection of checks and actual payment pursuant to any Notice of 
Guaranteed Delivery. 

   If an Exercising Shareholder does not make payment of any additional 
amounts due, the Trust reserves the right to take any or all of the following 
actions: (i) apply any payment received by it toward the purchase of the 
greatest whole number of Shares which could be acquired by such Exercising 
Shareholder upon exercise of the Primary Subscription and/or 
Over-Subscription Privilege based on the amount of such payment; (ii) 
allocate the Shares subject to subscription rights to one or more other 
Shareholders; (iii) sell all or a portion of the Shares deliverable upon 
exercise of subscription rights on the open market and apply the proceeds 
thereof to the amount owed; and/or (iv) exercise any and all other rights or 
remedies to which it may be entitled, including, without limitation, the 
right to set-off against payments actually received by it with respect to 
such subscribed Shares. 


   An Exercising Shareholder will not have the right to cancel the exercise 
of Rights or rescind a purchase after the Subscription Agent has received 
payment, either by means of a Notice of Guaranteed Delivery or a check or 
money order, except as described under "The Offer--Notice of NAV Decline." 


   The risk of delivery of subscription forms and payments to the 
Subscription Agent will be borne by the Exercising Shareholder and not the 
Trust, the Dealer Manager, the Subscription Agent, the Information Agent or 
broker-dealers designated by the Dealer Manager. If the mail is used to 
exercise Rights, insured registered mail is recommended. 

Notice of NAV Decline 

   The Trust will suspend the Offer until it amends this Prospectus if, 
subsequent to the effective date of this Prospectus, the Trust's NAV declines 
more than 10% from its NAV as of that date. In such event, the Trust will 
notify Shareholders of any such decline and thereby permit them to cancel 
their exercise of their Rights. 

                                      18 
<PAGE> 

Delivery of Stock Certificates 

   Registered Shareholders who are participants in the Trust's Dividend 
Reinvestment Plan (the "Plan") will have any Shares that they acquire 
pursuant to the Offer credited to their Shareholder dividend reinvestment 
accounts in the Plan. Shareholders whose Shares are held of record by Cede or 
by any other depository or nominee on their behalf or their broker-dealers' 
behalf will have any Shares that they acquire pursuant to the Offer credited 
to the account of Cede or such other depository or nominee. With respect to 
all other Shareholders, stock certificates for all Shares acquired pursuant 
to the Offer will be mailed after payment for all the Shares subscribed for 
has cleared, which clearance may take up to fifteen days from the date of 
receipt of the payment. 

Employee Plan Considerations 

   Shareholders that are employee benefit plans subject to the Employee 
Retirement Income Security Act of 1974, as amended ("ERISA") (including 
corporate savings and 401(k) plans), profit sharing/retirement plans for 
self-employed individuals and Individual Retirement Accounts (collectively, 
"Retirement Plans") should be aware that additional contributions of cash to 
the Retirement Plan (other than rollover contributions or trustee-to-trustee 
transfers from other Retirement Plans) in order to exercise Rights would be 
treated as Retirement Plan contributions and therefore, when taken together 
with contributions previously made, may be treated as excess or nondeductible 
contributions subject to excise taxes. In the case of Retirement Plans 
qualified under Section 401(a) of the Internal Revenue Code of 1986, as 
amended (the "Code"), additional cash contributions could cause violations of 
the maximum contribution limitations of Section 415 of the Code or other 
qualification rules. Retirement Plans in which contributions are so limited 
should consider whether there is an additional source of funds available 
within the Retirement Plan, including the liquidation of assets, with which 
to exercise the Rights. Because the rules governing Retirement Plans are 
extensive and complex, Retirement Plans contemplating the exercise of Rights 
should consult with their counsel prior to such exercise. 

   Retirement Plans and other tax exempt entities, including governmental 
plans, should also be aware that if they borrow in order to finance their 
exercise of Rights, they may become subject to the tax on unrelated business 
taxable income under Section 511 of the Code. If any portion of an Individual 
Retirement Account ("IRA") is used as security for a loan, the portion so 
used is treated as a distribution to the IRA depositor. 

   ERISA contains fiduciary responsibility requirements, and ERISA and the 
Code contain prohibited transactions rules that may affect the exercise of 
Rights. Due to the complexity of these rules and the penalties for 
noncompliance, Retirement Plans should consult with their counsel regarding 
the consequences of their exercise of Rights under ERISA and the Code. 

Certain Federal Income Tax Consequences of the Offer 

   The following discussion summarizes the principal federal income tax 
consequences of the Offer to Shareholders and Exercising Shareholders. It is 
based upon the Code, U.S. Treasury regulations, Internal Revenue Service 
rulings and policies and judicial decisions in effect on the date of this 
Prospectus. This discussion does not address all federal income tax aspects 
of the Offer that may be relevant to a particular Shareholder in light of his 
individual circumstances or to Shareholders subject to special treatment 
under the Code (such as insurance companies, financial institutions, 
tax-exempt entities, dealers in securities, foreign corporations, and persons 
who are not citizens or residents of the U.S.), and it does not address any 
state, local or foreign tax consequences. Accordingly, each Shareholder 
should consult his or her own tax advisor as to the specific tax consequences 
of the Offer to him or her. Each Shareholder should also review the 
discussion of certain tax considerations affecting the Trust and Shareholders 
set forth under "Taxation" below. 

   For federal income tax purposes, neither the receipt nor the exercise of 
the Rights by Shareholders will result in taxable income to those 
Shareholders, and no loss will be realized if the Rights expire without 
exercise. 

   A Shareholder's holding period for a Share acquired upon exercise of a 
Right begins with the date of exercise. A Shareholder's basis for determining 
gain or loss upon the sale of a Share acquired upon the exercise of a Right 
will be equal to the sum of the Shareholder's basis in the Right, if any, and 
the Subscription Price per Share. The Shareholder's basis in the Right will 
be zero unless either (i) the fair market value of the Right on the date of 
distribution is 15% or more of the fair market value on such date of the 
Shares with respect to which the Right was distributed, or (ii) the 
Shareholder elects, on its federal income tax return for the taxable year in 
which the Right is received, to allocate part of the basis of such Shares to 
the Right. If either of clauses (i) and (ii) is applicable, 

                                      19 
<PAGE> 

then if the Right is exercised, the Exercising Shareholder will allocate its 
basis in the Shares with respect to which the Right was distributed between 
such Shares and the Right in proportion to the fair market values of each on 
the date of distribution. A Shareholder's gain or loss recognized upon a sale 
of a Share acquired upon the exercise of a Right will be a capital gain or 
loss (assuming the Share was held as a capital asset at the time of sale) and 
will be a long-term capital gain or loss if the Share was held at the time of 
sale for more than one year. 

   The foregoing is only a summary of the applicable federal income tax laws 
presently in effect and does not include any state or local tax consequences 
of the Offer. Shareholders should consult their own tax advisers concerning 
the tax consequences of this transaction. 

                               USE OF PROCEEDS 


   
   Assuming all Shares offered hereby are sold at an estimated Subscription 
Price (the "Estimated Subscription Price") of $17.67 per Share, the net 
proceeds of the Offer will be approximately $35,702,709, after deducting 
commissions and expenses payable by the Trust estimated at approximately 
$368,000. The net proceeds of the Offer will be invested in accordance with 
the Trust's investment objective and policies. See "Investment Objective and 
Policies." Various factors affect investments in emerging growth companies 
that are different from factors affecting investments in large well-known 
companies, including the additional research required to investigate a large 
number of small companies and the volatility and illiquidity of securities of 
those companies. Accordingly, initial investment of the proceeds in publicly 
traded securities may take place during a period of up to six months 
following completion of the Offer, depending on market conditions and the 
availability of appropriate securities. Restricted Securities will be 
purchased as appropriate opportunities arise, which could take up to one year 
or longer, and the Trust may choose to be more fully invested in publicly 
traded securities during such period. Pending investment in the securities 
described above, the proceeds will be held in obligations of the U.S. 
Government, its agencies or instrumentalities ("U.S. Government Securities"), 
highly rated money market instruments or mutual funds that invest in such 
instruments. 
    



                             DESCRIPTION OF TRUST 


   The Trust is a diversified, closed-end management investment company. The 
Trust was organized as a Massachusetts business trust on October 31, 1986 
pursuant to a Declaration of Trust governed by Massachusetts law and 
commenced operations on April 22, 1987. The Trust's principal offices are 
located at 50 Rowes Wharf, Fourth Floor, Boston, MA 02110-3328. 


   The Trust's capitalization consists of an unlimited number of shares of 
beneficial interest, $.01 par value. Each Share represents an equal 
proportionate beneficial interest in the Trust and, when issued and 
outstanding, will be fully paid and non-assessable by the Trust. Upon any 
liquidation of the Trust, Shareholders will be entitled to share pro rata in 
the net assets of the Trust available for distribution. The Trust will send 
annual and semi-annual financial statements to Shareholders and may also 
issue more abbreviated interim reports to update Shareholders on a quarterly 
basis. The Trust will hold annual meetings of its Shareholders in accordance 
with the provisions of the Trust's By-laws and the rules of the NYSE. 

   Shareholders are entitled to one vote for each Share held. The Trust's 
Shares do not have cumulative voting rights, which means that the holders of 
more than 50% of the Shares of the Trust voting for the election of Trustees 
can elect all of the Trustees, and, in such event, the holders of the 
remaining Shares will not be able to elect any Trustees. The Trust has a 
staggered Board, whereby one class of Trustees is elected each year. 


   The number of Shares outstanding as of the date of this Prospectus is 
6,346,009. Assuming that all Rights are exercised, an additional 2,115,336 
Shares will be issued. The Trust may, at its discretion, issue up to an 
additional 25% of the Shares in the Offer to honor over-subscription requests 
if sufficient Shares are not available from the Primary Subscription to honor 
all over-subscriptions. 



   For information regarding risk factors pertaining to the Trust, see 
"Appendix A--Risk Factors and Investment Techniques." 


                                      20 
<PAGE> 


   

                              INVESTMENT ADVISER 

   Hambrecht & Quist Capital Management Incorporated, an investment adviser
registered under the Investment Advisers Act of 1940, has served as Investment
Adviser to the Trust since its inception in 1987. The Investment Adviser has,
since 1992, also provided investment advisory services to another closed-end
investment company, H&Q Life Sciences Investors ("HQL"), which invests in
companies in the healthcare industries and related industries such as
agricultural and environmental technology. Alan G. Carr, the President and a
Trustee of the Trust, the President and sole Director of the Investment Adviser,
as well as the President and a Trustee of HQL, is responsible for managing the
Trust's portfolio. Mr. Carr is currently the portfolio manager for the Trust and
HQL, which have aggregate net assets of approximately $265.4 million as of the
date of this Prospectus. Prior to joining the Investment Adviser at its
inception in 1986, Mr. Carr was portfolio manager for three mutual funds, with
aggregate net assets in excess of $300 million, sponsored by Putnam Companies
and dedicated to investment in the healthcare industries. Mr. Carr has been
managing equity portfolios emphasizing investment in emerging growth companies
for over 30 years and portfolios specializing in publicly traded equity
securities of Healthcare Companies, as well as in venture capital opportunities
in the healthcare industries, for the last 15 years.
    



   The Investment Adviser is an indirect wholly-owned subsidiary of Hambrecht 
& Quist Group ("Group"), which through various related entities has broad 
investment experience in the healthcare industries. Hambrecht & Quist LLC 
("H&Q"), an indirect wholly-owned subsidiary of Group, is a registered 
broker-dealer that specializes in providing investment research on and 
securities brokerage and investment banking services to emerging growth 
companies. H&Q has a respected research team dedicated solely to healthcare 
industries. Since 1982, H&Q has sponsored a healthcare conference, which is 
dedicated to companies in the healthcare industries. At the 1997 Conference, 
over 240 such companies made presentations to approximately 3,000 
participants. H&Q has major domestic offices in San Francisco, CA; New York, 
NY; and Boston, MA and its affiliates have offices in several foreign 
countries. Venture capital entities associated with Group have managed 
venture capital funds from domestic and international sources since 1970. 


   While the Investment Adviser has benefited from the information available 
to it because of its relationship with Group, the staff of the Investment 
Adviser remains responsible for obtaining all necessary information in the 
exercise of its due diligence obligations and making independent judgments 
with respect to investment decisions. The Investment Adviser is responsible 
for the day-to-day operations of the Trust, including selection of the 
Trust's portfolio investments. 

   The Investment Advisory Agreement between the Investment Adviser and the 
Trust (the "Advisory Agreement") provides that, subject to the supervision 
and direction of the Board, the Investment Adviser is responsible for the 
actual management of the Trust's portfolio. The Investment Adviser is also 
obligated to supervise or perform certain administrative and management 
services for the Trust and is obligated to provide the office space, 
facilities, equipment and personnel necessary to perform its duties under the 
Advisory Agreement. 


   For the services provided by the Investment Adviser under the Advisory 
Agreement, the Trust will pay a fee, computed and payable monthly, equal when 
annualized to (i) 2.5% of the average net assets for such month of its 
Restricted Securities (as defined) up to 25% of net assets; and (ii) 1.0% of 
the average net assets for such month of all other assets. The aggregate 
monthly fee paid to the Investment Adviser may not exceed, when annualized, 
1.375% of the Trust's average total net assets for such month (approximately 
 .115% per month). Because the advisory fee is based on the net assets of the 
Trust and since the Offer is expected to result in an increase in net assets, 
the Investment Adviser should benefit from the Offer by an increase in the 
dollar amount of its fee. 



                                      21 
<PAGE> 

                            TRUSTEES AND OFFICERS 

   The names, addresses and ages of the Trustees and Officers of the Trust 
are set forth below, together with their position and their principal 
occupations during the past five years, and, in the case of the Trustees, 
their positions with certain other organizations and publicly held companies. 

<TABLE>
<CAPTION>
                                                                           Principal Occupation 
Names, Ages and Addresses           Position with the Trust               and Other Affiliations 
- -------------------------           -----------------------               ---------------------- 
<S>                                <C>                        <C>
Alan G. Carr* (62)                 President and Trustee      President and Trustee, H&Q Life Sciences Investors 
50 Rowes Wharf                     (since 1986)               ("HQL") (since 1992); President (since 1992), Senior 
Boston, MA 02110                                              Vice President (1986-1992) and sole Director (since 
                                                              1986), Hambrecht & Quist Capital Management 
                                                              Incorporated ("HQCM"); and Managing Director, 
                                                              Hambrecht & Quist Group ("Group") (since 1992). 

William R. Hambrecht* (61)         Trustee                    Chairman (since 1992), President (1982-1992), Chief 
One Bush Street                    (since 1994)               Executive Officer (1982-1987) and Co-Chief 
San Francisco, CA 94104                                       Executive Officer (1987-1994), Group; Director 
                                                              (since 1982) of Adobe Systems Inc.; and Trustee, 
                                                              HQL (since 1994). Beneficial owner of approximately 
                                                              13% of the voting securities of Group. 

Lawrence S. Lewin** (58)           Trustee                    Chairman and Chief Executive Officer (since 1970), 
9300 Lee Highway                   (since 1987)               The Lewin Group (a healthcare public policy and 
Fairfax, VA 22031                                             management consulting firm), a subsidiary of 
                                                              Quintiles Transnational Corp.; Director, Apache 
                                                              Medical Systems (since 1989); and Trustee, HQL (since 
                                                              1992). 

Robert P. Mack, M.D. (61)          Trustee                    Orthopedic Surgeon, Steadman-Hawkins Orthopedic 
Box 7030                           (since 1991)               Clinic (since 1996); Orthopedic Surgeon, Denver 
Avon, CO 81620                                                Orthopedic Clinic (1977-1996); and Trustee, HQL 
                                                              (since 1992). 

Eric Oddleifson** (61)             Trustee                    Managing Director, UBS Resource Investments (forest 
50 South Street                    (since 1992)               and agriculture properties investments) (since 
Hingham, MA 02043                                             1995); President, Director and Chief Executive 
                                                              Officer, Resource Investments, Inc. (forest and 
                                                              agriculture properties investments) (1984-1995); 
                                                              and Trustee, HQL (since 1992). 

Uwe E. Reinhardt, Ph.D. (59)       Trustee                    Professor of Economics, Princeton University (since 
Woodrow Wilson School              (since 1988)               1968); and Trustee, HQL (since 1992). 
Princeton University 
Princeton, NJ 08544 



                                      22 
<PAGE> 

                                                                           Principal Occupation 
Names, Ages and Addresses           Position with the Trust               and Other Affiliations 
- -------------------------           -----------------------               ---------------------- 

Henri A. Termeer** (50)            Trustee                    Chairman (since 1988), Chief Executive Officer 
Genzyme Corporation                (since 1989)               (since 1985) and President (since 1983), Genzyme 
One Kendall Square                                            Corporation (human healthcare products company); 
Cambridge, MA 02139                                           Director, ABIOMED, Inc.(since 1987); Director, 
                                                              Geltex Pharmaceutical, Inc. (since 1994); Director, 
                                                              AutoImmune, Inc. (since 1992); Director of Genzyme 
                                                              Transgenics (since 1993); and Trustee, HQL (since 
                                                              1992). 

Kerri A. Bisner (34)               Secretary                  Vice President (since 1994), Assistant Vice 
50 Rowes Wharf                     (since 1992)               President (1991-1994), Research Associate 
Boston, MA 02110                                              (1989-1991), HQCM; and Secretary, HQL (since 1992). 

Kimberley L. Carroll (40)          Treasurer and Chief        Vice President (since 1991) and Assistant Vice 
50 Rowes Wharf                     Financial Officer          President (1987-1991), HQCM; and Treasurer and Chief 
Boston, MA 02110                   (since 1987) and           Financial Officer, HQL (since 1992). 
                                   Assistant Secretary 
                                   (1987-1992) 
</TABLE>

- ------------- 
 * Trustee considered to be an "interested person" as defined in Section 
   2(a)(19) of the Investment Company Act of 1940, as amended, (the 
   "Investment Company Act") because of his position or affiliation with the 
   Trust's Investment Adviser or its parent, Group. 
** Member of the Trust's Audit Committee. 

                                      23 
<PAGE> 

                      INVESTMENT OBJECTIVE AND POLICIES 

General 


   The Trust's investment objective is to seek long-term capital appreciation 
by investing primarily in Healthcare Companies. The Trust's investment 
objective is a fundamental policy and may not be changed without the 
affirmative vote of the holders of a majority of the Trust's outstanding 
Shares (as defined). For a more detailed description of the Trust's 
investment objective and policies see "Additional Information about 
Investments and Investment Techniques" and "Investment Restrictions" in the 
SAI. For a description of the risks that may be associated with an investment 
in the Trust see "Appendix A--Description of Risk Factors and Investment 
Techniques." 



   In an effort to achieve its investment objective, the Trust will invest 
primarily in securities of U.S. and foreign companies that are believed by 
the Investment Adviser to have significant potential for above-average 
long-term growth in revenues and earnings. The Investment Adviser expects 
that such companies generally will, in its judgment, possess most of the 
following characteristics: current or anticipated strong market position for 
their services or products, experienced business management, recognized 
technological expertise and the ability either to generate funds internally 
to finance growth or to secure outside sources of capital. The Investment 
Adviser will attempt to invest in securities that sell at price-earnings 
ratios or at multiples of underlying asset values which, relative to other 
comparable securities or to the company's growth expectations, do not fully 
reflect the company's potential. 


   The Trust emphasizes investment in securities of emerging growth 
Healthcare Companies, some of which may offer limited products or services or 
which are at the research and development stage with no marketable or 
approved products or technologies. The securities of most emerging growth 
Healthcare Companies in which the Trust will invest are expected to be traded 
in the over-the-counter market or restricted as to public resale. The Trust 
may invest up to 40% of its net assets in Restricted Securities. The Trust 
may invest in securities of large, well-known companies with existing 
products in the healthcare industries that are believed by the Investment 
Adviser to be undervalued in relation to their long-term growth potential or 
asset value. 

   The Trust may invest up to 20% of its net assets in Foreign Securities. 
The Trust may buy and sell currencies for the purpose of settlement of 
transactions in Foreign Securities, but presently does not intend to engage 
in hedging operations. 

   Under normal market conditions, the Trust will invest at least 80% of its 
net assets in securities of companies in the healthcare industries and in no 
event will have less than 25% of its net assets so invested. For purposes of 
satisfying the foregoing requirements, a company will be deemed to be a 
Healthcare Company if, at the time the Trust makes an investment therein, 50% 
or more of such company's sales, earnings or assets arise from or are 
dedicated to health services or medical technology activities. The Trust may 
also invest in companies that do not satisfy the above criteria but that are 
expected by the Investment Adviser to have 25% or more of sales, earnings or 
assets arising from or dedicated to such activities, but investments in such 
companies will not at the time of investment exceed 20% of the Trust's net 
assets. Determinations as to whether a company is a Healthcare Company will 
be made by the Investment Adviser in its discretion. 

   The equity and related securities in which the Trust may invest consist of 
common stock of Healthcare Companies and, to a lesser extent, of preferred 
stock, convertible debt, and warrants or other rights to acquire common or 
preferred stocks of such companies. The Trust's investments in venture 
capital opportunities will be made primarily in convertible preferred stock. 
The Trust may also purchase non-convertible debt securities in connection 
with its venture capital investments, and otherwise when the Investment 
Adviser believes that such investments would be consistent with the Trust's 
investment objective. Because of the risk characteristics associated with 
venture capital investments for emerging growth companies, such investments 
may be regarded as highly speculative. 

   Investments will not be made in any company with the objective of 
exercising control over that company's management. The Trust may make 
investments contemporaneously with other venture capital groups that may 
provide issuers with significant managerial assistance. 

   When, in the opinion of the Investment Adviser, adverse market conditions 
or industry expectations support such action, the Trust may, for temporary 
defensive purposes, invest up to 75% of its net assets in money market 

                                      24 
<PAGE> 

instruments. See "Investment Techniques--Money Market Instruments" in 
Appendix A for a description of money market instruments in which the Trust 
may invest. 


   In addition, the Trust may, to a limited degree, enter into when-issued 
and delayed delivery transactions, forward foreign currency contracts and 
repurchase agreements, and lend its portfolio securities. Under normal market 
conditions the Trust does not intend to engage in such practices. See 
"Appendix A--Description of Risk Factors and Investment Techniques." 


   The Trust also has adopted certain other investment restrictions in an 
effort to achieve its investment objective. See "Investment Restrictions" in 
the Trust's SAI. 

Healthcare Industries 

   Investments in the healthcare industries are likely to continue to be the 
principal component of the Trust's portfolio and, except when the Trust 
assumes a temporary defensive position, will represent at least 25% of the 
Trust's net assets. This predominance reflects the size and diversity of the 
healthcare industries. 


   The healthcare industries constitute a large segment of the U.S. economy. 
The U.S. Department of Health and Human Services ("HHS") estimates national 
healthcare expenditures in 1995 at 14.2% of U.S. gross domestic product 
("GDP"), or $1,008 billion (in current dollars). This constitutes a 7.4% 
increase over U.S. healthcare expenditures in 1994. U.S. GDP is a measure of 
the total value of all goods and services produced in the U.S. over the 
course of a year. HHS expects that the healthcare industries will continue to 
grow both in absolute dollars and as a percentage of GDP. HHS estimates that 
healthcare expenditures in the U.S. could increase to as much as 15.9% of GDP 
in 2000. The Investment Adviser believes that, while the healthcare 
industries are undergoing significant change, they serve market sectors that 
are generally large and fragmented and growing at above-average rates, 
thereby providing potential investment opportunities for the Trust. 



Market Forces in Healthcare 

   Markets for healthcare products and services have undergone significant 
growth over the last 25 years. Factors contributing to this growth include 
demographic shifts tending to a more elderly population and technological 
advances which may lead to therapy, or possibly cures, for the many disease 
states for which there are no currently effective treatments. In addition, 
the Investment Adviser believes that worldwide consumer awareness and 
acceptance of new and innovative healthcare products continues to rise, 
stimulating demand, and that the rate of demographic and technological change 
may accelerate in the future, causing certain segments of the business to 
decline and others to experience growth. Investments in the companies 
developing products that benefit from these market forces may present 
potentially profitable opportunities. 

   Demographics. In the United States, persons age 65 and older consume three 
to four times more healthcare goods and services than do the rest of the 
population. The U.S. Social Security Administration ("SSA") estimates that in 
1996, 34 million Americans, or 12.8% of the population, were over age 65 
compared to 12.5% in 1990. By 2000, this segment is projected by SSA to grow 
to 40 million people in the U.S., or 13.3% of the population. 


   Technology. Advances in the fields of healthcare, particularly in 
biotechnology, diagnostics and electronics, are enhancing medical 
applications in existing markets and creating new markets. These advances 
have contributed to longevity as well as to an improved quality of life. In 
particular, the Investment Adviser believes that diagnostic techniques and 
therapeutic products have significantly changed the practice of medicine and 
will continue to do so for the foreseeable future. Diagnostic techniques have 
become more sophisticated and accurate, as well as less traumatic to the 
patient. Therapeutic products have become more effective, can be tailored to 
more specialized uses and, as a result of improved diagnostics, can be 
employed at an earlier stage of treatment for many diseases. Increasingly, 
new therapeutic products are being developed for previously diagnosable 
diseases for which no therapy was available, and diagnostics for patients for 
which therapy was available, but where patients that might benefit were not 
easily identifiable. Scientific discovery has, in recent years, been 
materially enhanced by advances in knowledge in the broad field of genomics, 
which has in turn been made possible by the ability of enhanced computer 
power to handle vast amounts of data and which also permits the 
characterization of molecular structure and the design of potentially active 
new drugs. 


   Demand. Both lengthened lifespan and improved technologies have 
contributed to the significant increases in demand for healthcare products 
and services in recent years. Consumers have become accustomed to access to 

                                      25 
<PAGE> 

a variety of healthcare products and services, and their awareness of the 
availability of innovations has increased through broadcast and print media 
and through internet disease-specific support groups and web pages. This 
suggests, in the opinion of the Investment Adviser, that the demand for such 
healthcare products and services should remain strong. 

   Cost Containment. The growing cost of providing healthcare has placed 
financial strains on government, employers and individuals. Government and 
so-called managed health programs increasingly operate by reimbursing 
healthcare providers at fixed rates or by transferring financial risk to 
providers under capitation contracts where the provider of services receives 
a fixed annual amount to provide specified services. The goal of containing 
cost increases may continue to adversely affect certain segments of the 
healthcare industries, particularly traditional providers such as hospitals, 
while creating significant opportunities for new products and services that 
permit care to be delivered more effectively in other settings. The 
increasing financial pressure caused by the constraints of paying for the 
rising demand for healthcare with limited financial resources is a trend that 
is expected to continue, and perhaps accelerate. For these reasons, the 
Investment Adviser favors investments in Healthcare Companies that the 
Investment Adviser believes can provide products and services of comparable 
quality to, but at a lower cost than, existing products and services, or that 
can develop more cost effective technologies, products and services. Cost 
containment can be achieved in numerous ways, including the development of 
products and procedures that may reduce or avoid hospitalizations or the time 
it takes to recover from an illness or injury, products and services that 
result in fewer side effects than existing treatments, and healthcare 
delivery facilities and services that provide treatment or therapy in a less 
costly environment. 

   Regulation. The FDA requires that approvals be obtained prior to marketing 
new products. The approval process can be lengthy, expensive and uncertain as 
to outcome and, when successful, can create barriers to competition not 
generally present in other industries. For companies with established 
approved products, these barriers tend to result in longer and more 
profitable product cycles than might otherwise exist. While appointment of a 
new FDA Commissioner may generate some uncertainty, in the opinion of the 
Investment Adviser, the trend of recent years toward more rapid approvals 
may, if anything, accelerate. For example, a record number of new chemical 
entities were approved for marketing by the FDA in 1996. 

   Patents. Many companies in the healthcare industries are developing 
innovative technologies for commercial products which may receive patent 
protection. The granting of a patent may result in an extensive period of 
market exclusivity and protection against competition, allowing the patent 
holder to realize several years of high returns from product sales or royalty 
revenues. Such proprietary intellectual property positions may act as 
barriers to competition and may also increase the possibility that any 
acquisition of such a company would be at a premium over its public or 
private valuation. 

   Industry Fragmentation. Approximately 1,400 publicly traded companies, as 
well as many private companies, compete in the worldwide healthcare markets 
today. The Investment Adviser believes that none of the industries within 
these markets are considered to be dominated by any one company or small 
group of companies, although certain companies may dominate a particular 
product segment. This industry fragmentation enhances the growth 
opportunities for both publicly and privately held companies and increases 
the number and diversity of investment opportunities available to the Trust. 
The Investment Adviser also believes that the growth, size and fragmentation 
of the healthcare industries will continue to encourage entrepreneurial 
activity in spite of cost containment trends and thereby provide a broad 
range of attractive venture capital investment opportunities. In addition, 
mergers and acquisitions for access to technology or to gain perceived 
critical size may also provide opportunities for capital gains. 

   Internationalization. The healthcare industries have become increasingly 
internationalized. U.S. companies compete on a large scale in the markets of 
Western Europe and Japan, which are the two principal non-U.S. healthcare 
markets. To a lesser extent, Western European and Japanese companies have 
increased their competition for U.S. markets. The Investment Adviser intends 
to continue to consider making public and private investments in Foreign 
Securities of Healthcare Companies, subject to the Trust's investment 
policies. 

Sectors Within Healthcare 

   The following categories illustrate some of the sectors in which 
Healthcare Companies operate, and some of the services and products that may 
be of investment interest to the Trust. 

                                      26 
<PAGE> 

   Biotechnology. Biotechnology firms employ new techniques, such as 
monoclonal antibodies, recombinant DNA, molecular structure analysis, and 
genomics to produce novel therapeutic and diagnostic products. Advances in 
molecular biology and the screening of compounds of possible utility have the 
potential to materially enhance the process of discovering useful new 
therapeutic products and to shorten the development period for, and reduce 
the cost of developing, such products. As biotechnology evolves from a 
research and development stage to a commercial stage, these techniques and 
products will have the potential to expand existing markets and to create new 
ones. The Investment Adviser believes that over 45 therapeutic products 
developed using these techniques have already received FDA market approval, 
as have several monoclonal antibody diagnostic tests. The Investment Adviser 
believes that most of these innovative approved products have achieved rapid 
commercial acceptance and that many are currently generating annual revenues 
in excess of $100 million. 

   It is estimated that more than 15 therapeutic products for a variety of 
diseases have completed human clinical trials and are awaiting FDA approval, 
that there are approximately 140 products in late stage (Phase III) human 
clinical trials and that over 1,000 products are in earlier stage trials and 
pre-clinical development. 

   Recently, public equity markets have provided substantial capital to the 
biotechnology industry, and a large number of major corporations have 
provided capital through significant acquisitions, equity investments and in 
connection with product license agreements. Federal government support of 
biotechnology research has contributed significantly to the invention and 
development of "break-through" products. It is estimated that in fiscal year 
1996, federal agencies provided over $5 billion of funding for biotechnology 
related research and development. 

   Pharmaceuticals. Investments in the securities of pharmaceutical companies 
may provide above-average investment returns where such companies benefit 
from prescription or over-the-counter drugs that enjoy unique market position 
due to superior therapeutic benefits, reduced side effects, patent protection 
or convenient dosage form. New drug delivery systems, including oral and 
transdermal sustained release systems, can supersede intravenous or 
injectable systems and have the potential to improve therapy not only through 
easier patient compliance with prescription directions but also by improved 
administration of consistently efficacious quantities of the compound. In 
addition to providing new clinical benefits, the delivery system may also 
extend market exclusivity with the accompanying future investment returns to 
the developer of a drug nearing patent expiration. Most of the large 
pharmaceutical companies are also investing heavily in the effort to produce 
future revenues and earnings through greater research and development 
expenditures, joint ventures with emerging growth Healthcare Companies and 
acquisitions of such companies. Cost containment measures by both the private 
and public sectors have impinged on the ability of many pharmaceutical 
companies to raise product prices as they had done in the past and have, in 
some instances, resulted in reduced product prices. The Investment Adviser 
believes that this has been a negative influence on stock prices of these 
companies in the last few years, and may continue to increase the risk of 
investing in this industry in the future, but may also present selective 
investment opportunities. A more favorable factor, however, is the gradual 
trend of more rapid FDA approvals of new drugs, especially for the treatment 
of AIDS and cancer. More new drugs were approved in 1996 than in any prior 
year. 

   Diagnostics. The accuracy, sophistication and cost effectiveness of 
diagnosis has improved dramatically through imaging systems, such as 
ultrasound and magnetic resonance imaging (MRI), as well as through improved 
chemical and biological tests. Many of the new systems and supplies are or 
will be available to the patient directly or at a physician's office, as well 
as in the hospital or independent laboratory. These innovations generally 
increase the likelihood of earlier diagnosis and more efficacious and cost 
effective treatment. Under development are new contrast agents to enhance the 
output from virtually all imaging modalities, which are being further 
improved by innovative computer programs that prepare the data for display. 
Advances in genetic testing are expected to improve the ability to treat 
diseases at earlier stages and to identify those people that may have a 
greater than average chance of contracting certain diseases. Advances in the 
ability to extract and test fetal cells from maternal blood may avoid the 
risky procedure of obtaining fetal cells by biopsy for such analysis. The 
Investment Adviser believes these current and potential advances may increase 
demand for diagnostic products. 

   Medical Equipment, Devices and Supplies. In addition to developing the 
surgical equipment that permits the dramatic increase in the number of 
procedures that can be performed on an out-patient basis, companies in this 
field continue to enhance their growth through improving techniques for joint 
replacement, monitors for physiological function and management of disease, 
and new generations of catheters and implantable devices to control and treat 
heart malfunction. The Investment Adviser believes that many of these 
companies dominate their 

                                      27 
<PAGE> 

subsectors, have benefitted from overall market growth and have been able to 
generate above-average investment returns. 

   Managed Healthcare. Many varieties of companies are engaged directly or 
indirectly in the delivery of healthcare to patients, including hospitals, 
nursing homes, inpatient and outpatient rehabilitation services and 
therapeutic services delivered to the home. The Investment Adviser believes 
that healthcare cost containment efforts will continue to reduce revenues to 
acute care hospitals and promote the delivery of therapy in other more 
efficient settings. These trends should enhance the delivery of increasingly 
sophisticated care at home, and the potential of outpatient surgery and 
rehabilitation and of specialized free-standing facilities, such as cancer 
chemotherapy treatment centers. The Investment Adviser also believes that 
cost pressures will, however, increasingly negatively impact many of such 
providers, and investment in these sectors is currently relatively 
underweighted in the portfolio. However, some sectors may benefit from these 
trends. In general, such companies are able simultaneously to improve quality 
and reduce the cost of care. For example, emerging is a new industry, 
Physician Practice Management, as medical practices, either general or 
specialist, combine in an attempt to become more efficient and to strengthen 
their negotiating position with providers in an environment of increased 
capitation. Key to success in the coming period of funding reduction will be 
the management of information, particularly such areas as claims processing, 
patient management direct costs and quality control, and ultimately 
automation of patient records. The Adviser expects that these areas will 
receive increased emphasis in the portfolio in the future. 

Other 

   The Trust may also invest in companies and industries that are benefitting 
from the growth of healthcare industries. These companies may include real 
estate investment trusts that derive their income from ownership, leasing or 
financing of healthcare facilities, manufacturers of nutritional products, 
and key suppliers of services or equipment. 


   Significant declines in the stock prices of many public companies in the 
healthcare industries have constrained the ability of some private companies 
to raise capital to finance their growth and fund research. The Investment 
Adviser also continues to believe that this presents opportunities, 
especially in its venture capital investing, as valuations seem attractive in 
comparison to the depressed stock prices of some publicly traded Healthcare 
Companies. Shares of many publicly traded Healthcare Companies also appear to 
be trading at attractive valuations when compared to the stocks of companies 
in many other industries, especially those industries that have historically 
been sensitive to economic cycles. 



                     PORTFOLIO TRANSACTIONS AND BROKERAGE 

   Subject to policies established by the Board, the Investment Adviser is 
primarily responsible for the execution of the Trust's portfolio transactions 
and the allocation of brokerage. In executing such transactions, the 
Investment Adviser will seek to obtain the best price and execution for the 
Trust, taking into account such factors as price, size of order, difficulty 
of execution, operational facilities of the firm involved, the firm's risk in 
positioning a block of securities, and research, market and statistical 
information provided by such firm. While the Investment Adviser generally 
seeks reasonably competitive commission rates, the Trust will not necessarily 
pay the lowest commission available. 

   The Trust intends to purchase and hold securities for long-term capital 
appreciation and it is not anticipated that frequent portfolio changes will 
be made for short-term trading purposes or to take advantage of short-term 
swings in the market. However, changes may be made in the portfolio 
consistent with the investment objective and policies of the Trust whenever 
changes are believed by the Investment Adviser to be in the best interest of 
the Trust and its Shareholders. Risk factors, particularly those relating to 
a specific security investment or to the market and economic conditions, may 
also affect the rate at which the Trust buys and sells its portfolio 
holdings. The Trust has no fixed policy with respect to portfolio turnover 
rate; however, it is anticipated that the annual turnover rate after the 
initial investment period normally will not exceed 50%. The portfolio 
turnover rate is calculated by dividing the lesser of purchases or sales of 
portfolio securities by the average monthly value of the Trust's portfolio 
securities. The Trust's portfolio turnover rate for the fiscal years ended 
September 30, 1996 and September 30, 1995 was 22.41% and 22.81%, 
respectively. 

                               NET ASSET VALUE 

   The NAV is computed based on the value as discussed below of the 
securities held by the Trust and is determined as of the close of the NYSE on 
the last business day of each month or on a more frequent basis as required 

                                      28 
<PAGE> 

by the Trustees. NAV is calculated by dividing the value of the securities 
held by the Trust plus any cash or other assets minus all liabilities, 
including accrued expenses, by the total number of Shares outstanding at such 
time. 

   Portfolio securities that are traded only on national securities exchanges 
are valued at the last sale price or, lacking any sales, at the mean between 
last bid and asked prices. Securities traded in the over-the-counter market 
which are National Market System securities are valued at the last sale 
price. Other over-the-counter securities are valued at the most recent bid 
prices as obtained from one or more dealers that make markets in the 
securities. Portfolio securities that are traded both in the over-the-counter 
market and on a national securities exchange are valued according to the 
broadest and most representative market, as determined by the Investment 
Adviser. Short- term investments that mature in 60 days or less are valued at 
amortized cost, unless the Board determines that such valuation does not 
constitute fair value. 

   Securities and assets for which market quotations are not readily 
available are valued at fair value as determined in good faith by the Board 
in accordance with the procedures hereinafter described. Such valuations and 
procedures will be reviewed periodically by the Board. The fair value of 
investments for which no market exists cannot be precisely determined. With 
respect to securities of a company in its early stages of development, 
valuation will typically be based upon their original cost to the Trust (the 
"cost method"). The cost method will be utilized until significant 
developments affecting the portfolio company provide a basis for use of an 
appraisal valuation (the "appraisal method"). The appraisal method will be 
based upon such factors as earnings and net worth and will also consider the 
market price for similar securities of comparable publicly traded companies. 
In the case of unsuccessful operations, the appraisal may be based upon 
liquidation value. Valuations based on the appraisal are necessarily 
subjective. The Trust also will use third party transactions in the portfolio 
company's securities as the basis of valuation (the "private market method"). 
The private market method will be used only with respect to actual 
transactions or actual firm offers by sophisticated, independent investors 
unaffiliated with the Investment Adviser or Group. Legal or contractual 
restrictions on the sale of portfolio securities by the Trust will be 
considered in the valuation of such securities. 

   Other assets, which include cash, prepaid and accrued items, accounts 
receivable and income on investments and from the sale of portfolio 
securities, are carried in accordance with generally accepted accounting 
principles, as are all liabilities. Liabilities primarily include accrued 
expenses, sums owed for securities purchased and dividends payable. 

                         DIVIDENDS AND DISTRIBUTIONS 


   The Trust expects to distribute to shareholders annually dividends of all 
or a portion of its investment company taxable income, if any. For federal 
income tax purposes, the Trust is required to distribute substantially all of 
its investment company taxable income for each year. Net capital gain (i.e., 
the excess of net long-term capital gain over net short-term capital loss), 
if any, may be distributed or may be retained at the discretion of the Board. 
"Investment company taxable income," as used herein, includes all interest 
and other ordinary income earned by the Trust on its portfolio holdings and 
net short-term capital gains in excess of net long-term capital losses, less 
the Trust's expenses. See "Taxation--Distributions." 


   The Trust's most recent distribution of net capital gains of $4.49 per 
share was payable to Shareholders of record on November 18, 1996. 


   Various factors will affect the level of the Trust's income, including the 
asset mix, the performance of the companies represented in the Trust's 
portfolio, and the Trust's use of hedging and fluctuations in the rate of 
exchange between foreign currencies and the U.S. dollar to the extent the 
Trust has invested in Foreign Securities. Each shareholder will have all 
dividends and distributions reinvested in Shares of the Trust issued pursuant 
to the Trust's Plan, unless the shareholder elects not to participate in the 
Plan. Shareholders who elect not to participate in the Plan will receive 
their dividends and distributions in cash. See "Dividend Reinvestment Plan." 
Notices will be provided in accordance with Section 19(a) of the Investment 
Company Act. 



                          DIVIDEND REINVESTMENT PLAN 

   Each shareholder holding Shares of the Trust will automatically be a 
participant in the Trust's Plan, unless the shareholder elects not to 
participate in the Plan. Under the Plan, whenever the Trust declares a 
distribution of dividends and capital gains payable in Shares or cash, the 
distribution of dividends and capital gains will be 

                                      29 
<PAGE> 

automatically reinvested by State Street Bank and Trust Company (the "Plan 
Agent"), in whole or fractional Shares of the Trust, as the case may be, for 
the accounts of the participating shareholders. Shareholders who specifically 
elect not to participate in the Plan will receive all distributions of 
dividends and capital gains in cash paid by check in U.S. dollars mailed 
directly to the shareholders (or if the Shares are held in street or other 
nominee name, then to the nominee) by the Custodian, as Dividend Disbursing 
Agent. Shareholders may receive more detailed information regarding the Plan 
from the Trust or the Plan Agent. Shareholders whose Shares are held in the 
name of a broker or nominee should contact such broker or nominee to 
determine whether or how they may participate in the Plan. 

   The Plan Agent serves as agent for the shareholders in administering the 
Plan. Participants in the Plan will receive Shares valued on the valuation 
date, generally at the lower of market price or NAV, except as specified 
below. The valuation date will be the dividend or distribution payment date 
or, if that date is not a trading day on the NYSE, the next trading day. 
Whenever the market price per Share is equal to or exceeds NAV on the 
valuation date, participants will be issued Shares at the greater of (i) NAV 
or (ii) 95% of the then current market price of the Shares. If the NAV of the 
Shares on the valuation date exceeds the market price of the Shares at that 
time, participants will receive Shares from the Trust valued at the market 
price. 


   Experience under the Plan may indicate that changes are desirable. 
Accordingly, the terms and conditions of the Plan may be amended or 
supplemented by the Plan Agent or the Trust at any time or times but, except 
when necessary or appropriate to comply with applicable law or the rules or 
policies of the Commission or any other regulatory authority, only by mailing 
to the shareholders appropriate written notice at least 90 days prior to the 
record date for the dividend or distribution. All correspondence concerning 
the Plan should be directed to the Plan Agent, State Street Bank and Trust 
Company, at P.O. Box 8200, Boston, MA 02266-8200. 



                                   TAXATION 

   The following discussion is based upon the advice of Dechert Price & 
Rhoads, counsel for the Trust, and is a general summary of the principal U.S. 
federal income tax considerations regarding an investment in the Trust. The 
discussion is based on laws, regulations, rulings and decisions currently in 
effect, all of which are subject to change (possibly with retroactive effect) 
or different interpretations. The discussion below does not purport to deal 
with all of the federal income tax consequences applicable to the Trust, or 
to all categories of investors, some of which may be subject to special 
rules. Each prospective shareholder is urged to consult with his or her own 
tax adviser with respect to the specific federal, state, local, foreign and 
other tax consequences of investing in Shares of the Trust. 

Taxation of the Trust 

   The Trust intends to qualify and elect to be treated each taxable year as 
a regulated investment company ("RIC") under the Code. The principal federal 
income tax benefits of qualifying as a RIC, as compared to an ordinary 
taxable corporation, are that a RIC generally is not itself subject to 
federal income tax on ordinary investment income and net capital gains that 
are currently distributed to its shareholders, and that the character of 
long-term capital gains which are recognized and properly designated by a RIC 
flows through to its shareholders, who receive (or are deemed to receive) 
distributions of such income. However, the Trust would be subject to 
corporate income tax (currently at a maximum marginal rate of 35%) on any 
undistributed income. 

Distributions 

   Dividends paid from investment company taxable income will be taxable to 
shareholders as ordinary income whether paid in cash or reinvested in the 
Trust's Shares. The Trust intends to distribute to its shareholders 
substantially all of its investment company taxable income, if any, for each 
year. It is anticipated that the Trust's income distributions will be paid 
annually in additional Shares unless the shareholder elects payment in cash. 
If a portion of the Trust's income consists of dividends paid by U.S. 
corporations, a portion of the dividends paid by the Trust may be eligible 
for the corporate dividends-received deduction. Distributions of the excess, 
if any, of net long-term capital gains over net short-term capital losses 
designated by the Trust as capital gain dividends will be taxable to 
shareholders as long-term capital gains, whether paid in cash or reinvested 
in the Trust's Shares, regardless of how long the shareholders have held the 
Trust's Shares, and will not be eligible for the dividends received deduction 
for corporations. Each year, shareholders will be notified as to the amount 
and federal tax status of all dividends and capital gains paid during the 
prior year. Such dividends and capital gains may also be subject 

                                      30 
<PAGE> 

to state or local taxes. Dividends declared in October, November, or December 
with a record date in such month and paid during the following January will 
be treated as having been paid by the Trust and received by shareholders on 
December 31 of the calendar year in which declared, rather than the calendar 
year in which the dividends are actually received. 

   Gain or loss realized upon the sale or exchange of Shares will be a 
capital gain or loss if the Shares are capital assets in the shareholder's 
hands and generally will be long-term or short-term, depending upon the 
shareholder's holding period for the Shares. Investors should be aware that 
any loss realized upon the sale or exchange of Shares held for six months or 
less will be treated as a long-term capital loss to the extent of any 
distributions or deemed distributions of long-term capital gain to the 
shareholder with respect to such Shares. In addition, any loss realized on a 
sale or exchange of Shares will be disallowed to the extent the Shares 
disposed of are replaced within a period of 61 days beginning 30 days before 
and ending 30 days after the Shares are disposed of, such as pursuant to the 
Plan. In such case, the basis of Shares acquired will be adjusted to reflect 
the disallowed loss. 

   If a shareholder has not furnished a certified correct taxpayer 
identification number (generally a Social Security number) and has not 
certified that withholding does not apply, or if the Internal Revenue Service 
has notified the Trust that the taxpayer identification number listed on the 
account is incorrect according to their records or that the shareholder is 
subject to backup withholding, federal law generally requires the Trust to 
withhold 31% from any dividends and/or redemptions (including exchange 
redemptions). Amounts withheld are applied to federal tax liability; a refund 
may be obtained from the Service if withholding results in overpayment of 
taxes. Federal law also requires the Trust to withhold up to 30% or the 
applicable tax treaty rate from ordinary dividends paid to certain 
nonresident alien and other non-U.S. shareholder accounts. 

   This is a brief summary of some of the tax laws that affect an investment 
in the Trust. Please see the SAI and a tax adviser for further information. 

                     CUSTODIAN, TRANSFER AGENT, DIVIDEND 
             DISBURSING AGENT, REGISTRAR, AND SUBSCRIPTION AGENT 


   The Trust's securities and cash are held under a custodian contract by 
State Street Bank and Trust Company (the "Custodian"), whose principal 
business address is 225 Franklin Street, Boston, MA 02110. 


   The Custodian also serves as Dividend Disbursing Agent, Transfer Agent and 
Registrar for Shares of the Trust and Subscription Agent in connection with 
the Offer. 

                          DISTRIBUTION ARRANGEMENTS 


   Prudential Securities Incorporated, One New York Plaza, New York, NY 
10292, will act as dealer manager for the Offer. Under the terms of and 
subject to the conditions contained in a Dealer Manager Agreement dated the 
date of this Prospectus, the Dealer Manager will provide financial advisory, 
marketing and solicitation services in connection with the Offer. The Trust 
has agreed to pay the Dealer Manager a fee for its financial, advisory, 
marketing and solicitation services equal to 3.50% of the aggregate 
Subscription Price for the Shares issued pursuant to the Offer. The Dealer 
Manager will reallow to the broker-dealer designated on the related Exercise 
Form a concession of 2.25% of the Subscription Price per Share for each Share 
issued pursuant to the Offer, provided that the designated broker-dealer has 
executed a confirmation accepting the terms of the Dealer Manager Agreement 
relating to the Offer. These fees will be borne by the Trust and indirectly 
by all of its Shareholders, including those who do not exercise their Rights. 


   In addition, the Trust has agreed to reimburse the Dealer Manager for its 
out-of-pocket expenses incurred in connection with the Offer up to a maximum 
of $150,000. The Trust and the Investment Adviser have also agreed to 
indemnify the Dealer Manager or contribute to losses arising out of certain 
liabilities, including liabilities under the Securities Act. 

                                LEGAL MATTERS 


   The validity of the Shares offered hereby will be passed on for the Trust 
by Dechert Price & Rhoads, Ten Post Office Square, Boston, MA 02109 and 
certain other legal matters will be passed on for the Dealer Manager by 
Morgan, Lewis & Bockius LLP, 1800 M Street, N.W., Washington, D.C., 20036. 



                                      31 
<PAGE> 

                                   EXPERTS 

   The financial statements of the Trust included herein has been so included 
in reliance upon the report of Arthur Andersen LLP, independent public 
accountants, and on their authority as experts in accounting and auditing. 
The services it provides include auditing the financial statements of the 
Trust, services related to filings by the Trust with the Commission and 
consultation on matters related to the preparation and filing of tax returns. 

                           REPORTS TO SHAREHOLDERS 

   The Trust will send unaudited semiannual reports and audited annual 
reports, including a list of investments held, to shareholders. The Trust has 
in the past also issued more abbreviated interim reports to registered 
shareholders and those requesting them. 

                            ADDITIONAL INFORMATION 


   The Trust is subject to the informational requirements of the Securities 
Exchange Act of 1934 and the Investment Company Act and in accordance 
therewith is required to file reports, proxy statements and other information 
with the Commission. Any such reports, proxy statements and other information 
can be inspected and copied at the public reference facilities of the 
Commission, Judiciary Plaza, 450 Fifth Street, N.W., Washington, D.C. 20549 
and at the Commission's New York Regional Office, 7 World Trade Center, Suite 
1300, New York, NY 10048 and Chicago Regional Office, 230 South Dearborn 
Street, Chicago, IL 60604. Copies of such materials can be obtained from the 
public reference section of the Commission at 450 Fifth Street, N.W., 
Washington, D.C. 20549, at prescribed rates. Reports, proxy statements and 
other information concerning the Trust can also be inspected at the offices 
of the NYSE, 20 Broad Street, New York, NY 10005. 


   A Registration Statement on Form N-2 relating to the Shares has been filed 
by the Trust with the Commission. This Prospectus does not contain all of the 
information set forth in the Registration Statement, including any exhibits 
and schedules thereto. For further information with respect to the Trust and 
the Shares offered hereby, reference is made to the SAI and the Trust's 
Registration Statement. Statements contained in this Prospectus as to the 
contents of any contract or other document referred to are not necessarily 
complete and in each instance reference is made to the copy of such contract 
or other document filed as an exhibit to the Registration Statement, each 
such statement being qualified in all respects by such reference. A copy of 
the Registration Statement may be inspected without charge at the 
Commission's principal office in Washington, D.C., and copies of all or any 
part thereof may be obtained from the Commission upon the payment of certain 
fees prescribed by the Commission. 

                              TABLE OF CONTENTS 
                                      OF 
                     STATEMENT OF ADDITIONAL INFORMATION 

<TABLE>
<CAPTION>
                                                                         Page 
                                                                       ------- 
<S>                                                                    <C>
Additional Information About Investments and Investment Techniques         2 
Investment Restrictions                                                    7 
Trustees and Officers                                                     10 
The Trust                                                                 11 
Investment Advisory Agreement                                             14 
Net Asset Value                                                           17 
Portfolio Transactions and Brokerage                                      18 
Dividend Reinvestment Plan                                                21 
Tax Matters                                                               22 
Custodian, Transfer Agent, Dividend Disbursing Agent and Registrar        28 
</TABLE>

                                      32 



<PAGE>


                   REPORT OF INDEPENDENT PUBLIC ACCOUNTANTS 

To the Shareholders and Board of Trustees 
of H&Q Healthcare Investors: 

   We have audited the accompanying balance sheet of H&Q Healthcare Investors 
(a Massachusetts business trust), including the Schedule of Investments as of 
September 30, 1996, and the related statements of operations and cash flows 
for the year then ended, and the statements of changes in net assets and 
financial highlights for the years presented. These financial statements and 
financial highlights are the responsibility of the Fund's management. Our 
responsibility is to express an opinion on these financial statements and 
financial highlights based on our audits. 

   We conducted our audits in accordance with generally accepted auditing 
standards. Those standards require that we plan and perform the audit to 
obtain reasonable assurance about whether the financial statements and 
financial highlights are free of material misstatement. An audit includes 
examining, on a test basis, evidence supporting the amounts and disclosures 
in the financial statements. Our procedures included confirmation of 
securities owned, as of September 30, 1996, by correspondence with the 
custodian. An audit also includes assessing the accounting principles used 
and significant estimates made by management, as well as evaluating the 
overall financial statement presentation. We believe our audits provide a 
reasonable basis for our opinion. 

   As discussed in Note 5, the financial statements include investment 
securities valued at $37,189,359 (25.2% of net assets) whose values have been 
determined by the Board of Trustees in the absence of readily ascertainable 
market values. However, because of the inherent uncertainty of valuation, the 
Board of Trustees' determination of values may differ significantly from the 
values that would have been used had a ready market existed for the 
securities and the difference could be material. 

   In our opinion, the financial statements and financial highlights referred 
to above present fairly, in all material respects, the financial position of 
H&Q Healthcare Investors as of September 30, 1996, the results of its 
operations and its cash flows for the year then ended, and the changes in its 
net assets and financial highlights for the years presented, in conformity 
with generally accepted accounting principles. 

Boston, Massachusetts                                        Arthur Andersen LLP
November 1, 1996

                                     F-1 
<PAGE> 

                           H&Q HEALTHCARE INVESTORS 

                 SCHEDULE OF INVESTMENTS--September 30, 1996 

<TABLE>
<CAPTION>
  SHARES                                                             VALUE 
- ------------                                                     -------------- 
<S>          <C>                                                 <C>
             CONVERTIBLE SECURITIES--13.1% 
             Convertible Preferred--12.6% 
1,666,667    Cubist Pharmaceuticals, Series C*                    $ 1,000,000 
500,000      CV Therapeutics, Series D*                               475,000 
207,500      CV Therapeutics, Series E (w/wts.)*                      197,125 
212,500      CV Therapeutics, Series G (w/wts.)*                      201,875 
80,202       Dyax, Class A Series 1*                                  160,402 
55,000       Dyax, Class A Series 3*                                  110,000 
222,222      EPR, Series A*                                           999,999 
1,100,000    Exelixis Pharmaceuticals, Series B*                    1,100,000 
308,707      Focal, Series D*                                         537,150 
116,106      Focal, Series E*                                         202,025 
1,330,645    HealthTech Services, Series A*                         1,650,000 
99,955       IBAH, Series A**                                       1,949,123 
400,000      InterVentional Technologies, Series E*                 1,000,000 
87,500       InterVentional Technologies, Series F*                   875,000 
15,000       InterVentional Technologies, Series G*                   150,000 
343,750      LocalMed, Series D*                                    1,375,000 
160,000      Masimo, Series D*                                      1,120,000 
135,000      PGS International, Escrow*                               162,000 
27,500       Terrapin Technologies, Series G*                       1,375,000 
187,969      Therion Biologics, Series B (w/wts.)*                    499,998 
3,268        Transkaryotic Therapies, Series B*                     2,098,056 
25,000       Transkaryotic Therapies, Series C*                       350,000 
270,270      Tularik, Series C*                                       999,999 
                                                                  ----------- 
                                                                  $18,587,752 
                                                                  ----------- 
PRINCIPAL 
  AMOUNT     Convertible Bonds and Notes--0.5% 
- ----------- 
$801,500     Therion Biologics, 10% Note due 1996 (w/wts.)        $   801,500 
                                                                  ----------- 
                                                                  $   801,500 
                                                                  ----------- 
             TOTAL CONVERTIBLE SECURITIES (Cost $17,917,021)      $19,389,252 
                                                                  ----------- 
 SHARES 
- ---------
             COMMON STOCKS--80.1% 
             Agricultural/Environmental Technology--6.7% 
63,000       Calgene**                                            $   315,000 
467,500      Catalytica**                                           1,928,438 
102,000      IDEXX Laboratories**                                   4,615,500 
94,697       Molten Metal Technology**                              3,030,304 
                                                                  ----------- 
                                                                  $ 9,889,242 
                                                                  ----------- 
             Biotechnology--29.2% 
100,000      Alkermes**                                           $ 1,562,500 
265,600      Ariad Pharmaceuticals**                                1,012,600 
58,000       BioChem Pharma**                                       2,327,250 
111,000      BioTransplant**                                          777,000 
</TABLE>

The accompanying notes are an integral part of these consolidated financial 
statements. 

                                     F-2 
<PAGE> 

                     SCHEDULE OF INVESTMENTS--(Continued) 

<TABLE>
<CAPTION>
  SHARES                                                 VALUE 
- ----------                                           -------------- 
<S>        <C>                                       <C>
           Biotechnology--continued 
238,898    BioTransplant*                               1,254,215 
2,760      BioTransplant Warrants*                          4,968 
6,300      BioTransplant Warrants*                         11,340 
1,150      BioTransplant Warrants*                          4,807 
110,000    Calypte Biomedical**                           948,750 
250,400    Calypte Biomedical*                          1,534,952 
200,000    Cell Therapeutics*                             670,000 
148,700    Cor Therapeutics**                           1,487,000 
494,117    Genta**                                        725,734 
71,659     Gilead Sciences**                            2,024,367 
205,000    ImmuLogic Pharmaceutical**                   1,665,625 
63,755     INCYTE Pharmaceuticals**                     3,155,873 
441,409    Martek Biosciences**                        11,035,225 
73,000     MedImmune**                                  1,040,250 
207,059    NABI**                                       2,458,826 
60,000     Neurogen**                                   1,515,000 
400,000    Oxford GlycoSystems Group*                     320,000 
13,867     Pharming B.V.*                               1,105,247 
349,166    Ribi ImmunoChem Research**                   1,440,310 
166,666    Ribi ImmunoChem Research Warrants*             131,666 
180,648    SEQUUS Pharmaceuticals**                     2,845,206 
74,096     SEQUUS Pharmaceuticals Warrants*               617,220 
112,500    Somatogen**                                  1,279,688 
29,162     Therion Biologics*                              77,571 
12,500     Transkaryotic Therapies Warrants*                  125 
                                                      ----------- 
                                                      $43,033,315 
                                                      ----------- 
           Contract Research Organizations--9.5% 
136,781    IBAH**                                     $   889,077 
299,865    IBAH Warrants*                               1,250,437 
193,605    IBAH Warrants*                                 758,932 
330,000    Phoenix International Life Sciences**        3,382,500 
105,200    Quintiles Transnational**                    7,705,900 
                                                      ----------- 
                                                      $13,986,846 
                                                      ----------- 
           Diagnostics--6.8% 
189,099    Biofield*                                  $ 1,293,437 
14,977     Biofield Warrants*                                 150 
14,977     Biofield Warrants*                                 150 
135,907    Cytyc**                                      2,038,605 
175,397    Cytyc*                                       1,973,216 
20,000     Integ**                                        207,500 
133,333    Integ*                                       1,037,331 
153,846    NeoPath*                                     2,221,536 
333,334    Quidel**                                     1,291,669 
                                                      ----------- 
                                                      $10,063,594 
                                                      ----------- 
</TABLE>

The accompanying notes are an integral part of these consolidated financial 
statements. 

                                     F-3 
<PAGE> 

                     SCHEDULE OF INVESTMENTS--(Continued) 

<TABLE>
<CAPTION>
    SHARES                                                                  VALUE 
 -------------                                                         --------------- 
<S>           <C>                                                      <C>
              Managed Care--4.1% 
116,000       Orthodontic Centers of America**                          $  2,363,500 
112,500       Vencor**                                                     3,628,125 
                                                                         ------------ 
                                                                        $  5,991,625 
                                                                         ------------ 
              Medical Supplies--10.0% 
62,456        Boston Scientific**                                       $  3,591,220 
108,968       EndoVascular Technologies**                                  1,307,616 
155,750       Exogen**                                                       623,000 
114,286       Heartstream*                                                 1,221,717 
176,534       Innotech*                                                    1,339,893 
137,457       KeraVision**                                                 2,061,855 
210,040       Landec**                                                     2,047,890 
50,409        Landec*                                                        368,490 
22,000        Perclose**                                                     489,500 
100,002       Ventritex**                                                  1,750,035 
                                                                         ------------ 
                                                                        $ 14,801,216 
                                                                         ------------ 
              Medical Specialty--7.8% 
546,000       Bioject Medical**                                         $    546,000 
129,420       Biomatrix**                                                  2,167,785 
14,120        Dyax*                                                           28,240 
2,528         Dyax Warrants*                                                      25 
239,000       Fuisz Technologies**                                         3,107,000 
180,000       Interpore**                                                    933,750 
113,569       Sepracor**                                                   1,604,162 
91,666        Spiros Development Units*                                    2,523,565 
137,000       Voxel**                                                        685,000 
                                                                         ------------ 
                                                                        $ 11,595,527 
                                                                         ------------ 
              Pharmaceuticals--6.0% 
160,000       Cortex Pharmaceuticals**                                  $    490,000 
125,000       Synaptic Pharmaceutical**                                    1,421,875 
181,667       Vivus**                                                      6,903,346 
                                                                         ------------ 
                                                                        $  8,815,221 
                                                                         ------------ 
              TOTAL COMMON STOCKS (Cost $69,576,985)                    $118,176,586 
                                                                         ------------ 
              TOTAL INVESTMENTS IN SECURITIES (Cost $87,494,006)        $137,565,838 
                                                                         ============ 
  PRINCIPAL 
     AMOUNT   TEMPORARY CASH INVESTMENTS--7.0% 
$5,200,000    Ford Motor Credit Corp., 5.28%, due 10/11/96              $  5,192,350 
5,200,000     General Motors Acceptance Corp., 5.30%, due 10/3/96          5,198,492 
                                                                         ------------ 
              TOTAL TEMPORARY CASH INVESTMENTS                          $ 10,390,842 
                                                                         ============ 
</TABLE>


- ------------- 


 * Non income-producing restricted security, valued by the Board of Trustees 
   (see Note 5). 

** Non income-producing publicly traded security (see Note 1). 

The accompanying notes are an integral part of these consolidated financial 
statements. 

                                     F-4 
<PAGE> 

                           H&Q HEALTHCARE INVESTORS 

                      BALANCE SHEET--September 30, 1996 

<TABLE>
<CAPTION>
<S>                                                                         <C>
                                  Assets 
Investments in securities, at value (identified cost $87,494,006; see 
  Schedule of Investments) (Notes 1, 3 and 5)                                $137,565,838 
Temporary cash investments, at amortized cost which approximates value 
  (see Schedule of Investments) (Note 1)                                       10,390,842 
                                                                            ------------ 
    Total investments                                                        $147,956,680 
Cash                                                                              301,049 
Prepaid expenses and other assets                                                  19,429 
                                                                            ------------ 
    Total assets                                                             $148,277,158 
                                                                            ------------ 

                               Liabilities 
Payable for investments purchased                                                $497,750 
Accrued advisory fee (Note 4)                                                     158,524 
Other accrued expenses                                                             68,379 
                                                                            ------------ 
    Total liabilities                                                            $724,653 
                                                                            ------------ 

                                Net Assets 
Shares of beneficial interest, par value $.01 per share, unlimited number 
  of shares authorized, amount paid in on 5,729,160 shares issued and 
  outstanding (Note 1)                                                        $71,929,826 
Accumulated net realized gain on investments                                   25,550,847 
Net unrealized gain on investments (Note 3)                                    50,071,832 
                                                                            ------------ 
    Total net assets (equivalent to $25.75 per share based on 5,729,160 
      shares outstanding)                                                    $147,552,505 
                                                                            ============ 
</TABLE>

The accompanying notes are an integral part of these consolidated financial 
statements. 

                                     F-5 
<PAGE> 

                           H&Q HEALTHCARE INVESTORS 

                           STATEMENT OF OPERATIONS 
                    For the Year Ended September 30, 1996 

<TABLE>
<CAPTION>
<S>                                                          <C>            <C>
 INVESTMENT INCOME (Note 1): 
Dividends                                                        $9,900 
Interest                                                        242,253 
                                                             ------------ 
  Total investment income                                                      $252,153 

EXPENSES: 
Advisory fees (Note 4)                                       $1,961,266 
Shareholder reporting                                            62,336 
Custodian fees                                                   58,063 
Trustees' fees and expenses                                      56,663 
Insurance expense                                                30,455 
Accounting and auditing fees                                     27,971 
Transfer agent fees                                              16,911 
Legal fees                                                       14,742 
Other                                                            45,543 
                                                             ------------ 
  Total expenses                                                              2,273,950 
                                                                            ------------ 
   Net investment (loss)                                                    $(2,021,797) 
                                                                            ------------ 

NET REALIZED AND UNREALIZED GAINS ON INVESTMENTS: 
Net realized gain on investments (Note 1)                                   $26,774,551 
Net increase in unrealized gain on investments                                5,212,708 
                                                                            ------------ 
  Net gain on investments                                                   $31,987,259 
                                                                            ------------ 
   Net increase in net assets resulting from operations                     $29,965,462 
                                                                            ============ 
</TABLE>

The accompanying notes are an integral part of these consolidated financial 
statements. 

                                     F-6 
<PAGE> 

                           H&Q HEALTHCARE INVESTORS 

                           STATEMENT OF CASH FLOWS 
                    For the Year Ended September 30, 1996 

<TABLE>
<CAPTION>
<S>                                                                  <C>
 CASH FLOWS FROM OPERATING ACTIVITIES: 
Dividends received                                                         $9,900 
Interest received                                                         254,949 
Operating expenses paid                                                (2,282,567) 
                                                                      ----------- 
  Net cash used for operating activities                              $(2,017,718) 
                                                                      ----------- 
CASH FLOWS FROM INVESTING ACTIVITIES: 
Sales and maturities of portfolio securities                         $234,104,327 
Purchases of portfolio securities                                    (228,684,370) 
                                                                      ----------- 
  Net cash provided by investing activities                            $5,419,957 
                                                                      ----------- 
CASH FLOWS FROM FINANCING ACTIVITIES: 
Cash distributions paid                                               $(6,769,939) 
Distributions reinvested                                                3,284,307 
                                                                      ----------- 
  Net cash used for financing activities                              $(3,485,632) 
                                                                      ----------- 
NET (DECREASE) IN CASH                                                   $(83,393) 
CASH AT BEGINNING OF YEAR                                                 384,442 
                                                                      ----------- 
CASH AT END OF YEAR                                                      $301,049 
                                                                      =========== 
RECONCILIATION OF NET INCREASE IN NET ASSETS RESULTING FROM 
OPERATIONS TO NET CASH USED FOR OPERATING ACTIVITIES: 
Net increase in net assets resulting from operations                  $29,965,462 
Net realized (gain) on investments                                    (26,774,551) 
Net (increase) in unrealized gain on investments                       (5,212,708) 
Net decrease in interest and dividends receivables                         12,696 
(Decrease) in accrued advisory fees and accrued other expenses             (7,032) 
(Increase) in prepaid expenses and other assets                            (1,585) 
                                                                      ----------- 
  Net cash used for operating activities                              $(2,017,718) 
                                                                      =========== 
</TABLE>

The accompanying notes are an integral part of these consolidated financial 
statements. 

                                     F-7 
<PAGE> 

                           H&Q HEALTHCARE INVESTORS 

                      STATEMENT OF CHANGES IN NET ASSETS 

<TABLE>
<CAPTION>
                                                                      For the years ended 
                                                                 September 30,   September 30, 
                                                                     1996            1995 
                                                                     ----            ---- 
<S>                                                             <C>              <C>
NET INCREASE IN NET ASSETS FROM OPERATIONS: 
Net investment (loss)                                             $(2,021,797)     $(1,267,141) 
Net realized gain on investments                                   26,774,551        5,912,514 
Net increase in unrealized gain on investments                      5,212,708       24,258,241 
                                                                 ------------    ------------- 
  Net increase in net assets resulting from operations            $29,965,462      $28,903,614 
                                                                 ------------    ------------- 

DISTRIBUTIONS TO SHAREHOLDERS FROM: 
Net realized long-term capital gains                              $(6,769,939)              -- 
                                                                 ------------    ------------- 
  Net (decrease) in net assets resulting from distributions       $(6,769,939)              -- 

CAPITAL SHARE TRANSACTIONS: 
Value of shares issued in reinvestment of distributions            $3,284,307               -- 
                                                                 ------------    ------------- 
  Total increase in net assets                                    $26,479,830      $28,903,614 
                                                                 ------------    ------------- 

NET ASSETS: 
Beginning of year                                                 121,072,675       92,169,061 
                                                                 ------------    ------------- 
End of year                                                      $147,552,505     $121,072,675 
                                                                 ============    ============= 
</TABLE>

The accompanying notes are an integral part of these consolidated financial 
statements. 

                                     F-8 
<PAGE> 

                           H&Q HEALTHCARE INVESTORS 


                             FINANCIAL HIGHLIGHTS 
  (Selected data for each Share outstanding throughout the period indicated) 



<TABLE>
<CAPTION>
                                                  For the years ended September 30, 
                             ---------------------------------------------------------------------------- 
                                 1996            1995            1994           1993           1992 
                            --------------- --------------- -------------- --------------  -------------- 
<S>                         <C>             <C>             <C>            <C>             <C>
Net asset value per share: 
 Beginning of period              $21.818         $16.609         $17.604        $17.340        $19.207 
                             ------------    ------------    ------------   ------------   ------------ 
Net investment income 
  (loss)                          $(0.331)        $(0.228)        $(0.199)       $(0.190)       $(0.076) 
Net realized and 
  unrealized gain (loss) on 
  investments                       5.487           5.437          (0.230)         0.970          0.247 
Federal income taxes on 
  retained long-term 
  capital gains                        --              --          (0.566)        (0.516)        (1.078) 
                             ------------    ------------    ------------   ------------   ------------ 
  Total increase 
  (decrease) from 
    investment operations          $5.156          $5.209         $(0.995)        $0.264        $(0.907) 
                             ------------    ------------    ------------   ------------   ------------ 
Distribution to 
  shareholders 
 Short-term capital gains              --              --              --             --        $(0.040) 
 Long-term capital gains          $(1.220)             --              --             --         (0.920) 
                             ------------    ------------    ------------   ------------   ------------ 
  Total distributions             $(1.220)             --              --             --        $(0.960) 
                             ------------    ------------    ------------   ------------   ------------ 
Net asset value per share: 
 End of period                    $25.754         $21.818         $16.609        $17.604        $17.340 
                             ============    ============    ============   ============   ============ 
Per share market value: 
 End of period                    $20.875         $18.250         $15.125        $18.375        $19.375 
Total investment return 
  (a)                               22.03%          20.66%         (17.69)%        (5.16)%         9.43% 
Net assets: 
 End of period               $147,552,505    $121,072,675     $92,169,061    $97,690,739    $96,222,175 

RATIOS AND SUPPLEMENTAL DATA: 
Ratio of operating 
  expenses to average net 
  assets                            1.62%           1.76%           1.74%          1.84%          1.72% 
Ratio of net investment 
  (loss) to average net 
  assets                           (1.44)%         (1.31)%         (1.13)%        (1.06)%        (0.38)% 
Portfolio turnover rate            22.41%          22.81%          28.10%         28.36%         35.45% 
Average commission rate 
  paid per listed share 
  purchased (a)                     $.07             N/A             N/A            N/A            N/A 
Number of shares 
  outstanding at end of 
  period                        5,729,160       5,549,198       5,549,198      5,549,198      5,539,450 
</TABLE>


- ------------- 



* Annualized 


(a) Average commission rate per share required for fiscal years that began 
    September 1, 1995, or later; total investment return information not 
    required for fiscal years 1987 through 1989. 

The accompanying notes are an integral part of these consolidated financial 
statements. 

                                     F-9 
<PAGE> 

                           H&Q HEALTHCARE INVESTORS 

                        FINANCIAL HIGHLIGHTS--(Continued)


<TABLE>
<CAPTION>
                                                                                        For the period 
                                                                                        April 22, 1987 
                                                                                         (commencement 
                                        For the years ended September 30,                of operation) 
                                                                                       to September 30, 
                               1991            1990           1989           1988            1987 
                          --------------- -------------- -------------- --------------  ---------------- 
<S>                       <C>             <C>            <C>            <C>             <C>
Net asset value per 
  share: 
 Beginning of period            $11.313         $10.647         $8.036         $9.450          $9.250 
                           ------------    ------------   ------------   ------------    ------------ 
Net investment income 
  (loss)                        $(0.014)         $0.014         $0.003        $(0.019)         $0.030 
Net realized and 
  unrealized gain (loss) 
  on investments                  8.743           0.652          2.608         (1.375)          0.170 
Federal income taxes on 
  retained long-term 
  capital gains                      --              --             --             --              -- 
                           ------------    ------------   ------------   ------------    ------------ 
  Total increase 
  (decrease) from 
    investment operations        $8.729          $0.666         $2.611        $(1.394)         $0.200 
                           ------------    ------------   ------------   ------------    ------------ 
Distribution to 
  shareholders 
 Short-term capital gains       $(0.055)             --             --             --              -- 
 Long-term capital gains         (0.780)             --             --        $(0.020)             -- 
                           ------------    ------------   ------------   ------------    ------------ 
  Total distributions           $(0.835)             --             --        $(0.020)             -- 
                           ------------    ------------   ------------   ------------    ------------ 
Net asset value per 
  share: 
 End of period                  $19.207         $11.313        $10.647         $8.036          $9.450 
                           ============    ============   ============   ============    ============ 
Per share market value: 
 End of period                  $18.375          $9.250         $9.750         $6.375          $5.625 
Total investment return 
  (a)                           113.06%           1.37%           N/A            N/A             N/A 
Net assets: 
 End of period             $106,396,527     $62,661,275    $58,974,336    $44,515,399     $52,366,673 

RATIOS AND SUPPLEMENTAL DATA: 
Ratio of operating 
  expenses to average net 
  assets                          1.73%           1.74%          1.89%          1.98%           1.83%* 
Ratio of net investment 
  (loss) to average net 
  assets                         (0.10)%          0.12%          0.02%         (0.25)%          0.74%* 
Portfolio turnover rate          23.04%          47.02%         46.90%         57.42%          17.34%* 
Average commission rate 
  paid per listed share 
  purchased (a)                     N/A             N/A            N/A            N/A             N/A 
Number of shares 
  outstanding at end of 
  period                      5,539,450       5,539,450      5,539,450      5,539,450       5,539,450 
</TABLE>

- ------------- 
* Annualized. 

(a) Average commission rate per share required for fiscal years that began 
    September 1, 1995, or later; total investment return information not 
    required for fiscal years 1987 through 1989. 

The accompanying notes are an integral part of these consolidated financial 
statements. 

                                     F-10 
<PAGE> 

                           H&Q HEALTHCARE INVESTORS 
                        NOTES TO FINANCIAL STATEMENTS 
                              September 30, 1996 

(1) ORGANIZATION 

   H&Q Healthcare Investors (the Fund) is a Massachusetts business trust 
registered under the Investment Company Act of 1940 as a diversified 
closed-end management investment company. The Fund's investment objective is 
long-term capital appreciation through investment in securities of companies 
in the healthcare industries. The Fund invests primarily in securities of 
public and private companies that are believed to have significant potential 
for above-average growth. The Fund was organized on October 31, 1986 and 
commenced operations on April 22, 1987. 

   The preparation of these financial statements requires the use of certain 
estimates by management in determining the entity's assets, liabilities, 
revenues and expenses. Actual results could differ from these estimates. The 
following is a summary of significant accounting policies consistently 
followed by the Fund, which are in conformity with those generally accepted 
in the investment company industry. 

Investment Securities 

   Transactions related to the investments of the Fund are recorded on the 
date the securities are purchased or sold. Investments traded on national 
securities exchanges or in the over-the-counter market that are National 
Market System securities are valued at the last sale price or, lacking any 
sales, at the mean between the last bid and asked prices. Other 
over-the-counter securities are valued at the most recent bid prices as 
obtained from one or more dealers that make markets in the securities. As 
indicated in Note 5, investments for which market quotations are not readily 
available are valued at fair value as determined in good faith by the Board 
of Trustees of the Fund. Temporary cash investments with a maturity of 60 
days or less are valued at amortized cost. 

   Gains and losses from sales of investments are recorded using the 
"identified cost" method for both financial reporting and Federal income tax 
purposes. Investment income and expenses are recorded on the accrual basis. 

Federal Income Taxes 

   It is the Fund's policy to comply with the requirements of the Internal 
Revenue Code applicable to regulated investment companies and to distribute 
to its shareholders substantially all of its taxable income and its net 
realized capital gains, if any. Therefore, no Federal income tax provision is 
required. 

Distributions 

   The Fund records all distributions to shareholders from net investment 
income and realized gains on the ex-dividend date. Such distributions are 
determined in conformity with income tax regulations. The Fund has adjusted 
for the effect of certain permanent book/tax differences. Of the $2,021,797 
net operating loss, $366,279 was available to offset certain realized capital 
gains and the balance was reclassified against capital. This adjustment has 
no effect on the Fund's net assets, net investment loss or net realized gain 
and is designed to present the Fund's capital accounts on a tax basis. 

Dividend Reinvestment Plan 

   Under the Dividend Reinvestment Plan, net realized capital gains will 
automatically be paid in additional shares of the Fund, unless the Plan Agent 
(State Street Bank and Trust Company) is otherwise instructed by the 
shareholder. It is expected that dividends, if any, will be declared after 
fiscal year-end and will be payable for that year before the end of January. 

   A description of the automatic Dividend Reinvestment Plan may be obtained 
by calling State Street Bank. Shareholders may request to be paid in cash 
instead of shares by contacting the bank, brokerage or nominee who holds the 
shares if the shares are held in "street name" or by filling out an 
Authorization Card obtained by calling State Street Bank if the shares are in 
registered form. 

                                     F-11 
<PAGE> 

                           H&Q HEALTHCARE INVESTORS 
                  NOTES TO FINANCIAL STATEMENTS--(Continued) 
                              September 30, 1996 

(2) PURCHASES AND SALES OF INVESTMENT SECURITIES 

   The aggregate cost of purchases and proceeds from sales of investment 
securities (other than temporary cash investments) for the period from 
October 1, 1995 through September 30, 1996 totaled $31,022,848 and 
$45,401,195, respectively. 

(3) TAX BASIS OF SECURITIES 

   At September 30, 1996, the total cost of securities for Federal income tax 
purposes was $87,494,006. The aggregate gross unrealized gain on securities 
in which there was an excess of market value over cost was $63,873,734. The 
aggregate gross unrealized loss on securities in which there was an excess of 
cost over market value was $13,801,902. The net unrealized gain on securities 
held by the Fund was $50,071,832. 

(4) ADVISORY AGREEMENT 

   The Fund has entered into an Investment Advisory Agreement (the Advisory 
Agreement) with Hambrecht & Quist Capital Management Incorporated (the 
Adviser). Pursuant to the terms of the Advisory Agreement, the Fund pays the 
Adviser a monthly fee at the rate when annualized of (i) 2.5% of the average 
net assets for the month of its venture capital and other restricted 
securities and (ii) 1% of the average net assets for the month of all other 
assets. The aggregate fee may not exceed a rate when annualized of 1.375%. 
The Adviser is a wholly owned subsidiary of Hambrecht & Quist Group. Certain 
officers and trustees of the Fund are also officers of the Adviser. 

(5) VENTURE CAPITAL AND OTHER RESTRICTED SECURITIES 

   The Fund may invest in venture capital or other restricted securities if 
these securities would currently comprise 40% or less of net assets. The 
value of these securities represents 25.2% of the Fund's net assets at 
September 30, 1996. 

   The value of the venture capital or other restricted securities are valued 
at fair value as determined in good faith by the Board of Trustees. However, 
because of the inherent uncertainty of valuations, these estimated values may 
differ significantly from the values that would have been used had a ready 
market for the securities existed, and the differences could be material. The 
following table details the acquisition date, cost, carrying value per unit, 
and value of the Fund's venture capital or other restricted securities at 
September 30, 1996, as determined by the Board of Trustees of the Fund. 

<TABLE>
<CAPTION>
                                                             Carrying 
                                Acquisition                    Value 
Security                           Date           Cost       per Unit       Value 
- --------                           ----           ----       --------       -----  
<S>                               <C>          <C>            <C>         <C>
Biofield 
Common*                           11/4/93      $1,000,229 
                                  9/16/94         250,002 
                                   3/3/95         172,125 
                                  6/29/95         103,122 
                                                1,525,478     $6.840     $1,293,437 
Common Warrants                    3/3/95               0 
                                  6/29/95               0 
                                              ----------- 
                                                        0      0.010            150 
Common Warrants                    3/3/95               0 
                                  6/29/95               0 
                                              ----------- 
                                                        0      0.010            150 

                                     F-12 
<PAGE> 

                           H&Q HEALTHCARE INVESTORS 
                  NOTES TO FINANCIAL STATEMENTS--(Continued) 
                              September 30, 1996 

                                                             Carrying 
                                Acquisition                    Value 
Security                           Date           Cost       per Unit       Value 
- --------                           ----           ----       --------       -----  
BioTransplant 
Common*                           11/1/93      1,200,696 
                                 10/31/94        277,857 
                                  8/18/95         48,757 
                                  1/16/96        385,385 
                                              ----------- 
                                               1,912,695       5.250      1,254,215 
Common Warrants                   8/12/94              0       1.800          4,968 
Common Warrants                  10/31/94              0       1.800         11,340 
Common Warrants                   8/18/95              0       4.180          4,807 
Calypte Biomedical 
Common*                          12/22/92      1,000,476 
                                 11/18/94         52,000 
                                  6/15/95        100,000 
                                  2/29/96        150,000 
                                              ----------- 
                                               1,302,476       6.130      1,534,952 
Cell Therapeutics 
Common                             8/3/92      1,000,280       3.350        670,000 
Cubist Pharmaceuticals 
Series C Cvt. Pfd.                5/17/95      1,000,809       0.600      1,000,000 
CV Therapeutics 
Series D Cvt. Pfd.                3/23/94      1,000,330       0.950        475,000 
Series E Cvt. Pfd. (w/wts.)        9/8/95        415,613       0.950        197,125 
Series G Cvt. Pfd. (w/wts.)       3/29/96        425,425       0.950        201,875 
Cytyc* 
Common                            5/17/94        151,447 
                                 10/14/94        149,608 
                                  6/13/95         84,460 
                                              ----------- 
                                                 385,515      11.250      1,973,216 
Dyax 
Common                            5/16/91      1,001,480       2.000         28,240 
Class A Series 1 Cvt. Pfd.         6/1/92        155,065 
                                  9/11/92         51,712 
                                 12/31/92        111,812 
                                              ----------- 
                                                 318,589       2.000        160,402 
Class A Series 3 Cvt. Pfd.       10/26/95        110,280       2.000        110,000 
Common Warrants                  12/31/92            187       0.010             25 
EPR 
Series A Cvt. Pfd.                 3/9/94      1,000,409       4.500        999,999 
Exelixis Pharmaceuticals 
Series B Cvt. Pfd.                3/28/96      1,101,325       1.000      1,100,000 

                                     F-13 
<PAGE> 

                           H&Q HEALTHCARE INVESTORS 
                  NOTES TO FINANCIAL STATEMENTS--(Continued) 
                              September 30, 1996 

                                                             Carrying 
                                Acquisition                    Value 
Security                           Date           Cost       per Unit       Value 
- --------                           ----           ----       --------       -----  
Focal 
Series D Cvt. Pfd.                9/17/93        922,564 
                                   8/5/94        220,382 
                                              ----------- 
                                               1,142,946       1.405        537,150 
Series E Cvt. Pfd.               10/17/95        202,466       1.740        202,025 
HealthTech Services 
Series A Cvt. Pfd.                1/26/96      1,652,603       1.240      1,650,000 
Heartstream* 
Common                            3/15/95        800,433      10.690      1,221,717 
IBAH# 
Common Warrants                   2/22/93              0       3.920        758,932 
Common Warrants                   8/11/95        192,500       4.170      1,250,437 
Innotech* 
Common                            8/23/95      1,100,677       7.590      1,339,893 
Integ* 
Common                            6/16/95        800,126       7.780      1,037,331 
InterVentional Technologies 
Series E Cvt. Pfd.                 4/2/91        500,667       2.500      1,000,000 
Series F Cvt. Pfd.                8/21/92        700,399      10.000        875,000 
Series G Cvt. Pfd.                 3/8/95        150,431      10.000        150,000 
Landec* 
Common                            3/27/95        200,294       7.310        368,490 
LocalMed 
Series D Cvt. Pfd.                 2/9/96      1,376,301       4.000      1,375,000 
Masimo 
Series D Cvt. Pfd.                8/14/96      1,120,000       7.000      1,120,000 
NeoPath* 
Common                            3/15/94      1,000,209      14.440      2,221,536 
Oxford GlycoSystems Group 
Ordinary Shares                   5/26/93        773,830       0.800        320,000 
PGS International 
Escrow                            9/27/93              0       1.200        162,000 
Pharming B.V. 
Class B Shares                    8/28/95      1,105,430      79.703      1,105,247 
Ribi ImmunoChem Research** 
Common Warrants                   7/31/91              0       0.790        131,666 
SEQUUS Pharmaceuticals# 
Common Warrants                   3/30/95              0       8.330        617,220 
Spiros Development 
Units                            12/28/95      1,375,780      27.530      2,523,565 
Terrapin Technologies 
Series G Cvt. Pfd.                11/7/95      1,375,548      50.000      1,375,000 

                                     F-14 
<PAGE> 

                           H&Q HEALTHCARE INVESTORS 
                  NOTES TO FINANCIAL STATEMENTS--(Continued) 
                              September 30, 1996 

                                                             Carrying 
                                Acquisition                    Value 
Security                           Date           Cost       per Unit       Value 
- --------                           ----           ----       --------       -----  
Therion Biologics 
Common                            7/12/90           7,582       2.660         77,571 
Series B Cvt. Pfd. (w/wts.)       6/30/93         502,648       2.660        499,998 
10% Note due 1996 (w/wts.)       10/17/94         251,260 
                                  4/19/95          97,116 
                                  7/12/95          97,063 
                                 10/17/95          97,000 
                                  1/25/96          89,176 
                                   4/3/96          90,200 
                                  8/20/96          81,800 
                                              ----------- 
                                                  803,615       1.000        801,500 
Transkaryotic Therapies 
Series B Cvt. Pfd.               10/15/91       1,000,840 
                                  2/13/92          24,000 
                                  4/16/93         283,420 
                                              ----------- 
                                                1,308,260     642.000      2,098,056 
Series C Cvt. Pfd.                11/5/93         200,000      14.000        350,000 
Common Warrants                   11/5/93             245       0.010            125 
Tularik 
Series C Cvt. Pfd.                4/16/93       1,000,119       3.700        999,999 
                                              -----------               ------------- 
                                              $31,317,880                $37,189,359 
                                              ===========               ============= 
</TABLE>

- ------------- 

* Represents 75% of equivalent current market value of the issuer's 
registered securities. 

** Represents 70% of equivalent current market value of the issuer's 
registered securities. 

# Represents 100% of equivalent current market value of the issuer's 
registered securities. 



                                     F-15 
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<PAGE>


                                  APPENDIX A 
            DESCRIPTION OF RISK FACTORS AND INVESTMENT TECHNIQUES 

                                 RISK FACTORS 


   An investment in the Shares of the Trust involves a high degree of risk. 
Prospective investors should carefully consider the following risk factors in 
addition to the other information set forth in this Prospectus. For 
additional information of the risks that may be associated with an investment 
in the Trust see "Additional Information About Investments and Investment 
Techniques" in the SAI. 


   Because the Trust intends to invest substantially all of its assets in 
equity securities of Healthcare Companies, an investor should be aware of 
certain special considerations and risk factors relating to investments in 
such companies. No assurance can be given that Healthcare Companies will 
grow, that a sufficient number of appropriate investments will be available 
or that the Trust's particular investment choices will be successful. 
Investors should also be aware of considerations and risks relating to the 
Trust's investment practices. An investment in the Trust should not itself be 
considered a balanced investment program and is intended to provide 
diversification as part of a more complete investment program. The Trust is 
intended for long-term investors not seeking current income. 

Dilution of NAV and Effect of Non-Participation in the Offer 


   As a result of the terms of the Offer, Shareholders who do not fully 
exercise their Rights, including the Over- Subscription Privilege, will, at 
the completion of the Offer, own a smaller proportional interest in the Trust 
than they owned prior to the Offer and will experience a dilution of NAV. In 
addition, an immediate dilution of NAV will be experienced by all 
Shareholders as a result of the Offer whether or not they exercise all or a 
portion of their Rights, because the Subscription Price will be less than the 
then current NAV. Although it is not possible to state precisely the amount 
of such a decrease in value, because it is not known at this time how many 
Shares will be subscribed for or what the Subscription Price will be, such 
dilution could be significant. For example, if the assumed Subscription Price 
is $19.10, representing a market price which is only 90% of NAV, assuming 
that all Rights are exercised, the Trust's NAV would be reduced by 
approximately $.81 per Share or approximately 3.6% of NAV. However, the 
actual Subscription Price may be greater or less than such assumed 
Subscription Price. The foregoing example assumes an NAV of $22.33 per Share 
based on the Trust's NAV after the close of trading on Monday, February 3, 
1997. Since April 22, 1987 (commencement of operations), Shares of the Trust 
have traded at various times at both a discount and a premium to net asset 
value. 



Concentration in the Healthcare Industries 

   The Trust expects under normal market conditions to invest primarily in 
securities of Healthcare Companies representing a finite number of industries 
and to invest at least 25% of its net assets in securities of companies in 
the healthcare industries. The Trust's portfolio may therefore be more 
sensitive to, and possibly more adversely affected by, regulatory, economic 
or political factors or trends relating to the healthcare, agricultural and 
environmental technology industries than a portfolio of companies 
representing a larger number of industries. This risk is in addition to the 
risks normally associated with any strategy seeking capital appreciation by 
investing in a portfolio of equity securities. 

   Healthcare industries have in the past been characterized by limited 
product focus, rapidly changing technology and extensive government 
regulation. In particular, technological advances can render an existing 
product, which may account for a disproportionate share of a company's 
revenue, obsolete. Obtaining governmental approval from agencies such as the 
FDA for new products can be lengthy, expensive and uncertain as to outcome. 
Such delays in product development may result in the need to seek additional 
capital, potentially diluting the interests of existing investors such as the 
Trust. In addition, governmental agencies may, for a variety of reasons, 
restrict the release of certain innovative technologies of commercial 
significance, such as genetically altered material. These various factors may 
result in abrupt advances and declines in the securities prices of particular 
companies and, in some cases, may have a broad effect on the prices of 
securities of companies in particular healthcare industries. 

   While a concentration of investments in any healthcare industry or in 
Healthcare Companies generally may increase the risk and volatility of an 
investment company's portfolio, the Trust will endeavor to reduce risk by 
having a portfolio of investments that is diversified within its stated 
objective and policies. Such volatility is not limited 

                                      A-1

<PAGE> 

to the biotechnology industry, and companies in other industries may be subject
to similar abrupt movements in the market prices of their securities. No
assurance can be given that future declines in the market prices of securities
of companies in the industries in which the Trust may invest will not occur, or
that such declines will not adversely affect the NAV or the price of the Shares.

   Intense competition exists within and among certain healthcare industries, 
including competition to obtain and sustain proprietary technology 
protection. Healthcare Companies can be highly dependent on the strength of 
patents for maintenance of profit margins and market exclusivity. The complex 
nature of the technologies involved can lead to patent disputes, including 
litigation that could result in a company losing an exclusive right to a 
patent. Competitors of Healthcare Companies, particularly of the emerging 
growth Healthcare Companies that the Trust emphasizes, may have substantially 
greater financial resources, more extensive development, manufacturing, 
marketing and service capabilities, and a larger number of qualified 
managerial and technical personnel. Such competitors may succeed in 
developing technologies and products that are more effective or less costly 
than any that may be developed by Healthcare Companies in which the Trust 
invests and may also prove to be more successful in production and marketing. 
Competition may increase further as a result of potential advances in health 
services and medical technology and greater availability of capital for 
investment in these fields. 

   With respect to healthcare, cost containment measures already implemented 
by the federal government, state governments and the private sector have 
adversely affected certain sectors of these industries. There is increasing 
discussion at all levels of government, as to how to extend health insurance 
coverage to the millions of people in the U.S. who are currently uninsured 
while also restraining the growth of total healthcare expenditures. The 
implementation of any of the measures under discussion may create increased 
demand for healthcare products and services but also may have an adverse 
effect on some companies in the healthcare industries. No assurance can be 
given that healthcare reform legislation will be enacted or, if enacted, as 
to its ultimate form. 

   Certain Healthcare Companies in which the Trust may invest may be exposed 
to potential product liability risks that are inherent in the testing, 
manufacturing, marketing and sale of pharmaceutical and medical device 
products. There can be no assurance that a product liability claim would not 
have a material adverse effect on the business, financial condition or 
securities prices of a company in which the Trust has invested. 

Investment in Emerging Growth Companies 

   The Trust emphasizes investment in equity securities of emerging growth 
Healthcare Companies. While these securities offer the opportunity for 
significant capital gains, such investments also involve a degree of risk 
that can result in substantial losses. Some of the Healthcare Companies in 
which the Trust may invest are expected to be companies that are in a 
"start-up" stage of development, have little or no operating history, operate 
at a loss or with substantial variations in operating results from period to 
period, have limited products, markets, financial resources or management 
depth, or have the need for substantial additional "follow-up" capital to 
support expansion or to achieve or maintain a competitive position. Some of 
these Healthcare Companies may be emerging companies at the research and 
development stage with no marketable or approved products or technology. 
There can be no assurance that securities of start-up or emerging growth 
companies will, in the future, yield returns commensurate with their 
associated risks. 
Key Personnel 

   Alan G. Carr, the President and a Trustee of the Trust and President and 
sole Director of the Investment Adviser, is responsible for managing the 
Trust's portfolio. Mr. Carr has been managing equity portfolios emphasizing 
investment in emerging growth companies for over 30 years and portfolios 
specializing in publicly traded equity securities of Healthcare Companies, as 
well as in venture capital opportunities in the healthcare industries, for 
the last 15 years. There may be only a limited number of securities 
professionals who have comparable investment experience to Mr. Carr. In the 
event of his death, resignation, retirement or inability to act on behalf of 
the Investment Adviser, there can be no assurance that a suitable replacement 
for Mr. Carr could be found immediately. 

Liquidity of Portfolio Investments 


   The Trust may invest substantially all of its net assets in securities of 
emerging growth Healthcare Companies that are traded in the over-the-counter 
market or on regional stock exchanges where the low trading volume of a 
particular security may result in abrupt and erratic price movements. An 
investment in such securities may have


                                      A-2
<PAGE> 
limited liquidity, and the Trust may find it necessary to sell at a discount
from recent prices or to sell over extended periods of time when disposing of
such securities. In addition, the Trust may invest up to 40% of its net assets
in Restricted Securities, which by their terms are illiquid because they are
subject to legal or contractual restrictions on resale. The Trust cannot sell
Restricted Securities except in a public offering registered under the
Securities Act or pursuant to an exemption from registration under the
Securities Act, including a transaction in compliance with Rule 144 under the
Securities Act, which permits only limited sales under specified conditions
unless the Trust has held the securities for at least three years and is
unaffiliated with the issuer. Moreover, Restricted Securities are expected to
include venture capital investments that may take many years from the date of
initial investment to reach a state of maturity when public disposition can be
considered. Adverse conditions in the securities markets at certain times may
preclude a public offering of an issuer's unregistered securities. The lack of
an active secondary market and resale restrictions may result in the inability
of the Trust to sell a security at a fair price and may substantially delay the
sale of a security that the Trust seeks to sell. Companies whose securities are
not publicly traded are also not subject to the same disclosure and other legal
requirements as are applicable to companies with publicly traded securities.
Restricted Securities eligible for resale to qualified institutional buyers
pursuant to Rule 144A under the Securities Act are subject to the 40% limitation
described above.



Foreign Securities 

   The Trust may invest up to 20% of its net assets in Foreign Securities, 
many of which may be less liquid and have prices that are more volatile than 
securities of comparable U.S. companies. Foreign stock exchanges and brokers 
are generally subject to less governmental supervision and regulation than 
U.S. exchanges and brokers, and commissions on foreign stock exchanges are 
generally higher than negotiated commissions in the U.S. There may in certain 
instances be delays in the settlement of transactions effected in foreign 
markets. Certain countries restrict foreign investments in their securities 
markets. These restrictions may limit or preclude investment in certain 
countries or in certain industries or market sectors, or may increase the 
cost of investing in securities of particular companies. 

   Foreign companies are not generally subject to uniform accounting, 
auditing and financial reporting standards or to other regulatory 
requirements comparable to those applicable to U.S. companies. Thus, there 
may be less available information concerning non-U.S. issuers of securities 
held by the Trust than is available concerning U.S. companies. In addition, 
with respect to some foreign countries, there is the possibility of 
nationalization, expropriation, confiscatory taxation or establishment of 
exchange controls. Income earned in a foreign nation may be subject to 
taxation (including withholding taxes on interest and dividends), or other 
taxes may be imposed with respect to investments in foreign securities. Other 
risks associated with investments in foreign securities include difficulties 
in pursuing legal remedies and obtaining judgments in foreign courts, 
political or social instability and diplomatic developments that could 
adversely affect the Trust's investments in companies located in foreign 
countries. An investment in Foreign Securities may also involve a degree of 
currency risk. 

Market for Shares 


   The Shares are listed on the NYSE under the symbol "HQH." The shares of 
closed-end investment companies frequently trade at a discount to NAV but may 
trade at a premium. This is characteristic of shares of a closed-end fund and 
is a risk separate and distinct from the risk of a decline in the NAV as a 
result of a fund's investment activities. Because of this factor as well as 
the Trust's investment objective and policies, the Trust is designed 
primarily for long-term investors and should not be considered a vehicle for 
trading purposes. Since its initial public offering in April 1987, Shares 
have traded at various times at both a discount and a premium to NAV. The 
risk that the Shares may trade at a discount to NAV may be greater for 
investors expecting to sell their Shares in a relatively short period of 
time. The Trust cannot predict whether the Shares will trade in the future 
at, above or below NAV. 


Declaration of Trust 

   The Trust's Declaration of Trust presently has provisions that could have 
the effect of limiting the ability of other entities or persons to acquire 
control of the Trust, cause it to engage in certain transactions or modify 
its structure. The Board is divided into three classes, each having a term of 
three years. Each year the term of office of one class will expire: Alan G. 
Carr and Henri A. Termeer will continue in office until 1999, William R. 
Hambrecht, Robert P. Mack M.D., and Eric Oddleifson will continue in office 
until 1998, and Lawrence S. Lewin and Uwe



                                      A-3
<PAGE> 
E. Reinhardt, Ph.D. will continue in office until 1997. This provision could
delay for up to two years the replacement of a majority of the Board. A Trustee
may be removed from office only by vote of the holders of 66-2/3% of the Shares
of the Trust.

   In addition, the affirmative vote or consent of the holders of 75% of the 
Trust's Shares will be required generally to authorize any of the following 
transactions with a person or entity that is directly, or indirectly through 
affiliates, the beneficial owner of 5% or more of the outstanding Shares of 
the Trust: 

     (i)  the Trust's merger or consolidation with or into any other entity;

     (ii) the issuance of any securities of the Trust to any person or entity
          for cash (except pursuant to the Plan);

     (iii) the sale, lease or exchange of all or substantially all of the
          Trust's assets to or with any entity or person (except assets having
          an aggregate fair market value of less than $1,000,000); or

     (iv) the sale, lease or exchange to or with the Trust in consideration for
          securities of the Trust of any assets of any entity or person (except
          assets having an aggregate fair market value of less than $1,000,000).

   However, such 75% vote or consent will not be required with respect to the 
foregoing transactions where the Board under certain conditions approves the 
transaction. These provisions could have the effect of depriving shareholders 
of an opportunity to sell their Shares at a premium over prevailing market 
price by discouraging a third party from seeking to obtain control of the 
Trust in a tender offer or similar transaction. The Board has determined that 
the 75% voting requirements described above, which are greater than the 
minimum requirements under state law or the Investment Company Act, are in 
the best interests of the shareholders. 

Related Party Transactions 

   The Investment Adviser is an indirect wholly-owned subsidiary of Group, 
which through its various related entities has developed investment research, 
investment banking and venture capital expertise in the healthcare 
industries. The majority of the Board will be unaffiliated with the 
Investment Adviser; nevertheless, the Trust may be subject to certain 
potential conflicts of interest. H&Q, an indirect wholly-owned subsidiary of 
Group, may make a market in or underwrite new issues of securities of 
companies in which the Trust has invested. Although the Trust has no 
obligation to do so, it may place brokerage orders with brokers, including 
H&Q, who provide supplemental investment research and market and statistical 
information about the healthcare industries. In addition, investment 
companies advised by the Investment Adviser or venture capital funds managed 
by entities associated with Group may concurrently invest with the Trust in 
Restricted Securities under certain conditions, or provide managerial 
assistance to the issuers thereof. The Trust also may invest, subject to 
applicable law, in companies in which directors of the Investment Adviser or 
Trustees of the Trust have invested, or for which they serve as directors or 
executive officers. See "Portfolio Transactions and Brokerage." The 
Investment Company Act prohibits the Trust from engaging in certain 
transactions involving its "affiliates," including, among others, the Trust's 
Trustees, officers and employees, the Investment Adviser, H&Q and any 
"affiliates" of such affiliates except pursuant to an exemptive order or the 
provisions of certain rules under the Investment Company Act. In the view of 
the staff of the Commission, other investment companies advised by the 
Investment Adviser may, in some instances, be viewed to be affiliates of the 
Trust. Such legal restrictions and delays and costs involved in obtaining 
necessary regulatory approvals may preclude or discourage the Trust from 
making certain investments and no assurance can be given that any exemptive 
order sought by the Trust will be granted. 


                            INVESTMENT TECHNIQUES 

   In addition to the investment practices described above, the Trust may 
utilize the following investment practices: 

Money Market Instruments 

   When, in the opinion of the Investment Adviser, adverse market conditions 
or industry expectations support such action, the Trust may, for temporary 
defensive purposes, invest up to 75% of its net assets in money market 
instruments. 

   Money market instruments in which the Trust may invest include 
certificates of deposit and bankers' acceptances issued by domestic branches 
of federally-insured U.S. banks and savings and loan associations 


                                      A-4
<PAGE> 


and commercial paper and high and upper medium grade corporate debt securities
rated, as of the date of purchase, among the following rating categories of the
indicated rating service: bonds--Moody's Aaa, Aa or A; S&P AAA, AA or A;
notes--Moody's MIG-1, MIG-2 or MIG-3; S&P SP-1+ or SP-2; commercial
paper--Moody's P-1; S&P A-1. The Trust also may invest in shares of money market
mutual funds that invest in money market instruments and U.S. Government
Securities. Money market mutual funds are investment companies and the Trust's
investments in those companies are subject to certain limitations. As a
shareholder in money market mutual funds, the Trust will bear its ratable share
of such companies' expenses, including investment adviser or management fees,
and will remain subject to the payment of fees to the Investment Adviser. To the
extent that the Trust assumes a temporary defensive position for the purpose of
avoiding losses, it will not participate in the capital appreciation, if any, of
securities in which the Trust would normally invest.

When-Issued and Delayed Delivery Transactions 

   The Trust may purchase securities on a "when issued" basis or a "delayed 
delivery" basis. 

Repurchase Agreements 

   It is the Trust's present intention to enter into repurchase agreements 
for a relatively short period (usually not more than one week) only with 
commercial banks and registered broker-dealers and only with respect to U.S. 
Government Securities and money market instruments. 

Loans of Portfolio Securities 

   In an attempt to make productive use of its assets, the Trust may lend its 
portfolio securities, subject to the limitation that the Trust will not lend 
a security if, as a result of such loan, all securities then subject to loans 
would exceed 20% of the Trust's net assets. 

Hedging 

   In order to hedge against changes in the value of its portfolio securities,
the Trust may from time to time engage in certain hedging strategies. The Trust
will engage in hedging activities from time to time in the Investment Adviser's
discretion, and may not necessarily be engaging in such activities when
movements in the securities markets, foreign exchange rates, or interest rates
that could affect the value of the assets of the Trust occur.

Futures Contracts 

   The Trust may enter into contracts for the purchase or sale for future 
delivery (a "futures contract") of baskets of securities, financial indices, 
financial instruments or foreign currencies. The Trust would purchase or sell 
futures contracts to attempt to protect the value of its securities from 
market-wide price movements and fluctuations in interest or foreign exchange 
rates without actually buying or selling securities or foreign currency. 

Foreign Currency Transactions 

   The Trust may enter into forward foreign currency exchange contracts and 
may purchase and sell foreign currency futures contracts to protect against a 
decline in the U.S. Dollar equivalent value of its foreign currency portfolio 
securities or the payments thereon that may result from an adverse change in 
foreign currency exchange rates. 

   Under normal market conditions, the Trust currently does not intend to 
engage in the foregoing practices or investments with the exception of 
investments in money market instruments. 


                                      A-5


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<PAGE> 









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<PAGE> 


================================================================================



No dealer, salesperson or other person has been authorized to give any 
information or to make any representations other than those contained in this 
Prospectus in connection with the offer made by this Prospectus and, if given 
or made, such information or representations must not be relied upon as 
having been authorized by the Trust, the Trust's Investment Adviser or the 
Dealer Manager. This Prospectus does not constitute an offer to sell or the 
solicitation of any offer to buy any security other than the shares of 
beneficial interest offered by this Prospectus, nor does it constitute an 
offer to sell or a solicitation of any offer to buy the shares of beneficial 
interest by anyone in any jurisdiction in which such offer or solicitation is 
not authorized, or in which the person making such offer or solicitation is 
not qualified to do so, or to any such person to whom it is unlawful to make 
such offer or solicitation. Neither the delivery of this Prospectus nor any 
sale made hereunder shall, under any circumstances, create any implication 
that information contained herein is correct as of any time subsequent to the 
date hereof. However, if any material change occurs while this Prospectus is 
required by law to be delivered, the Prospectus will be amended or 
supplemented accordingly. 

                                ------------- 

<TABLE>
   
<CAPTION>
                              TABLE OF CONTENTS
                                                          Page 
                                                        --------- 
<S>                                                       <C>
Prospectus Summary                                          3 
Trust Expenses                                              8 
Financial Highlights and Investment Performance             9 
The Offer                                                  14 
Use of Proceeds                                            20 
Description of Trust                                       20 
Investment Adviser                                         21 
Trustees and Officers                                      22 
Investment Objective and Policies                          24 
Portfolio Transactions and Brokerage                       28 
Net Asset Value                                            28 
Dividends and Distributions                                29 
Dividend Reinvestment Plan                                 29 
Taxation                                                   30 
Custodian, Transfer Agent, Dividend Disbursing 
  Agent, Registrar and Subscription Agent                  31 
Distribution Arrangements                                  31 
Legal Matters                                              31 
Experts                                                    32 
Reports to Shareholders                                    32 
Additional Information                                     32 
Table of Contents of Statement of Additional 
  Information                                              32 
Report of Independent Public Accountants                  F-1 
Financial Statements                                      F-2 
Appendix A--Description of Risk Factors and 
  Investment Techniques                                   A-1 
</TABLE>
    


                               2,115,336 Shares 

                             H&Q HEALTHCARE INVESTORS 

                          Issuable Upon Exercise of 
                          Non-Transferable Rights to 
                              Subscribe for Such 
                                    Shares 


                                ------------- 
                                 PROSPECTUS 
                                ------------- 



                                Dealer Manager 
                      Prudential Securities Incorporated 



                               February 7, 1997 


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