H&Q HEALTHCARE INVESTORS
13F-HR, 1999-11-05
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<TABLE>
<CAPTION>
                                                 FORM 13F

Page     of                                 Name of Reporting Manager: HAMBRECHT & QUIST CAPITAL MANAGEMENT

- -----------------------------------------------------------------------------------------------------------
                                                                                                 Item 5:
                Item 1:                       Item 2:             Item 3:         Item 4:       Shares of
             Name of Issuer              Title of Class            CUSIP        Fair Market     Principal
                                                                  Number           Value         Amount

- -----------------------------------------------------------------------------------------------------------
<S>                                      <C>                     <C>            <C>             <C>
Affymetrix                               Common                  00826T108       4,921,875         50,000
- -----------------------------------------------------------------------------------------------------------
Amgen                                    Common                  031162100       6,112,500         75,000
- -----------------------------------------------------------------------------------------------------------
Aradigm                                  Common                  038505103       3,193,750        350,000
- -----------------------------------------------------------------------------------------------------------
Biofield                                 Common                  090591207          52,726        878,769
- -----------------------------------------------------------------------------------------------------------
Bioject Medical Technologies             Common                  09059T107         414,700        829,400
- -----------------------------------------------------------------------------------------------------------
Biomatrix                                Common                  09060P102       6,256,473        278,840
- -----------------------------------------------------------------------------------------------------------
Biopure                                  Common                  09065H915       1,240,843        169,746
- -----------------------------------------------------------------------------------------------------------
BioTransplant                            Common                  09066Y107       4,542,303        712,519
- -----------------------------------------------------------------------------------------------------------
Biovail                                  Common                  09067K106      10,606,750        209,000
- -----------------------------------------------------------------------------------------------------------
Calypte Biomedical                       Common                  131722100       1,568,430      1,433,993
- -----------------------------------------------------------------------------------------------------------
Catalytica                               Common                  148885106      18,099,990      1,206,666
- -----------------------------------------------------------------------------------------------------------
Celgene                                  Common                  151020104       7,848,125        290,000
- -----------------------------------------------------------------------------------------------------------
Cor Therapeutics                         Common                  217753102       2,850,000      1,012,700
- -----------------------------------------------------------------------------------------------------------
Coulter Pharmaceutical                   Common                  222116105       3,693,438        265,000
- -----------------------------------------------------------------------------------------------------------
Cubist Pharmaceuticals                   Common                  229990981      13,875,574      1,620,505
- -----------------------------------------------------------------------------------------------------------
CV Therapeutics                          Common                  126667104       7,806,094        533,750
- -----------------------------------------------------------------------------------------------------------
Cytyc                                    Common                  232946103      12,955,709        334,881
- -----------------------------------------------------------------------------------------------------------
Elan                                     Warrants                284131802       1,248,750         75,000
- -----------------------------------------------------------------------------------------------------------
Emisphere Technologies                   Common                  291345106       2,208,376        151,000
- -----------------------------------------------------------------------------------------------------------
Envirogen                                Common                  294040100          20,182         20,833
- -----------------------------------------------------------------------------------------------------------
EP Med Systems                           Common                  26899B914       3,225,000      1,075,000
- -----------------------------------------------------------------------------------------------------------
Focal                                    Common                  343909107       1,359,885        271,977
- -----------------------------------------------------------------------------------------------------------
Fuisz Technologies                       Common                  359536109       1,125,317        178,268
- -----------------------------------------------------------------------------------------------------------
Gene Logic                               Common                  368689105       2,209,375        350,000
- ---------------------------------------------------------------------------                ----------------
Gilead Sciences                          Common                  37555B103      22,893,050        356,659
- -----------------------------------------------------------------------------------------------------------
IDEXX Laboratories                       Common                  45168D104       4,304,688        250,000
- ---------------------------------------------------------------------------                ----------------
ImClone Systems                          Common                  45245W109       7,730,625        232,500
- -----------------------------------------------------------------------------------------------------------
Interpore Cross                          Common                  46062W107       2,517,500        380,000
- -----------------------------------------------------------------------------------------------------------
KeraVision                               Common                  648990992       2,680,405        206,185
- -----------------------------------------------------------------------------------------------------------
Landec                                   Common                  514766104       2,903,271        566,492
- -----------------------------------------------------------------------------------------------------------
LJL BioSystems                           Common                  501873103       3,210,581        969,232
- -----------------------------------------------------------------------------------------------------------
Lynx Therapeutics                        Common                  551812308       4,218,750        375,000
- -----------------------------------------------------------------------------------------------------------
Martek Biosciences                       Common                  572901106       4,486,288        780,224
- -----------------------------------------------------------------------------------------------------------
MedImmune                                Common                  584699102       3,986,250        110,000
- -----------------------------------------------------------------------------------------------------------
NeoPath                                  Common                  640517108       1,332,692        276,923
- -----------------------------------------------------------------------------------------------------------
Quintiles Transnational                  Common                  748767100       2,909,878        152,900
- -----------------------------------------------------------------------------------------------------------
Ribi ImmunoChem Research                 Common                  762553105       1,678,122        745,832
- -----------------------------------------------------------------------------------------------------------
Sepracor                                 Common                  817315104      13,481,958        178,569
- -----------------------------------------------------------------------------------------------------------
Synaptic Pharmaceutical                  Common                  871990982         937,500        187,500
- -----------------------------------------------------------------------------------------------------------
Teva Pharmaceutical Industries           Common                  881624209       2,515,626         50,000
- -----------------------------------------------------------------------------------------------------------
</TABLE>


<TABLE>
<CAPTION>
                                                                  FORM 13F
                                                                                                    ---------------------------
                                                                                                                 (SEC USE ONLY)
Page     of                  Name of Reporting Manager:  HAMBRECHT & QUIST CAPITAL MANAGEMENT
- -------------------------------------------------------------------------------------------------------------------------------
                                               Item 6:                                                 Item 8:
                Item 1:                  Investment Discretion              Item 7:            Voting Authority (Shares)
                                ----------------------------------------               ----------------------------------------
             Name of Issuer                  (b) Shared-                   Managers
                                  (a) Sole    As Defined   (c) Shared-   See Instr. V    (a) Sole    (b) Shared     (c) None
                                             in Instr. V      Other
- -------------------------------------------------------------------------------------------------------------------------------
<S>                                  <C>                                      <C>           <C>
Affymetrix                           X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
Amgen                                X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
Aradigm                              X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
Biofield                             X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
Bioject Medical Technologies         X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
Biomatrix                            X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
Biopure                              X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
BioTransplant                        X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
Biovail                              X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
Calypte Biomedical                   X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
Catalytica                           X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
Celgene                              X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
Cor Therapeutics                     X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
Coulter Pharmaceutical               X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
Cubist Pharmaceuticals               X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
CV Therapeutics                      X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
Cytyc                                X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
Elan                                 X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
Emisphere Technologies               X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
Envirogen                            X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
EP Med Systems                       X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
Focal                                X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
Fuisz Technologies                   X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
Gene Logic                           X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
Gilead Sciences                      X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
IDEXX Laboratories                   X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
ImClone Systems                      X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
Interpore Cross                      X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
KeraVision                           X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
Landec                               X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
LJL BioSystems                       X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
Lynx Therapeutics                    X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
Martek Biosciences                   X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
MedImmune                            X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
NeoPath                              X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
Quintiles Transnational              X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
Ribi ImmunoChem Research             X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
Sepracor                             X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
Synaptic Pharmaceutical              X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
Teva Pharmaceutical Industries       X                                        NA            X
- -------------------------------------------------------------------------------------------------------------------------------
</TABLE>
<PAGE>


<TABLE>
<CAPTION>
                                                 FORM 13F


Page     of                              Name of Reporting Manager:  HAMBRECHT & QUIST CAPITAL MANAGEMENT

- -----------------------------------------------------------------------------------------------------------
                                                                                                 Item 5:
                Item 1:                       Item 2:          Item 3:         Item 4:          Shares of
             Name of Issuer               Title of Class        CUSIP        Fair Market        Principal
                                                               Number           Value            Amount

- -----------------------------------------------------------------------------------------------------------
<S>                                      <C>                     <C>            <C>               <C>
Transkaryotic Therapies                  Common                  893735100      18,492,123        359,944
- -----------------------------------------------------------------------------------------------------------
Transkaryotic Therapies (Restricted)     Common                  893735100         990,757         24,106
- -----------------------------------------------------------------------------------------------------------
Triangle Pharmaceuticals                 Common                  89589H104       5,775,000        300,000
- -----------------------------------------------------------------------------------------------------------
Verdant Brands                           Common                  923366108         118,750         38,000
- -----------------------------------------------------------------------------------------------------------
Vivus                                    Common                  928551100       1,834,219        645,000
- -----------------------------------------------------------------------------------------------------------

- -----------------------------------------------------------------------------------------------------------
             COLUMN TOTALS                                                     221,512,323
- -----------------------------------------------------------------------------------------------------------

- -----------------------------------------------------------------------------------------------------------
</TABLE>


<TABLE>
<CAPTION>
                                                                FORM 13F
                                                                                                         ---------------------------
                                                                                                                   (SEC USE ONLY)
Page     of                           Name of Reporting Manager:  HAMBRECHT & QUIST CAPITAL MANAGEMENT
                                                                                                         ---------------------------
- ------------------------------------------------------------------------------------------------------------------------------------
                                                    Item 6:                                                 Item 8:
                Item 1:                             Investment Discretion       Item 7:                  Voting Authority (Shares)
                                      ---------------------------------------               ----------------------------------------
             Name of Issuer                       (b) Shared-                   Managers
                                       (a) Sole    As Defined   (c) Shared-   See Instr. V    (a) Sole    (b) Shared     (c) None
                                                  in Instr. V      Other
- ------------------------------------------------------------------------------------------------------------------------------------
<S>                                       <C>                                      <C>           <C>
Transkaryotic Therapies                   X                                        NA            X
- ------------------------------------------------------------------------------------------------------------------------------------
Transkaryotic Therapies (Restricted)      X                                        NA            X
- ------------------------------------------------------------------------------------------------------------------------------------
Triangle Pharmaceuticals                  X                                        NA            X
- ------------------------------------------------------------------------------------------------------------------------------------
Verdant Brands                            X                                        NA            X
- ------------------------------------------------------------------------------------------------------------------------------------
Vivus                                     X                                        NA            X
- ------------------------------------------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------------------------------------------
             COLUMN TOTALS
- ------------------------------------------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------------------------------------------
</TABLE>


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