EMISPHERE TECHNOLOGIES INC
SC 13D/A, 1997-03-21
PHARMACEUTICAL PREPARATIONS
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<PAGE>


                       SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C.  20549

                                  SCHEDULE 13D/A

                   Under the Securities Exchange Act of 1934
                               (Amendment No.  3 )*

                            EMISPHERE TECHNOLOGIES INC.
- --------------------------------------------------------------------------------
                                (Name of Issuer)

                                  COMMON STOCK
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)


                                   291345106
                        -------------------------------
                                 (CUSIP Number)
                     

                Alberto W. Vilar, Amerindo Investment Advisors Inc., 
                         One Embarcadero Center, Suite 2300,
              San Francisco, CA 94111-3162;  Telephone:  (415) 362-0292
- --------------------------------------------------------------------------------
                   (Name, Address and Telephone Number of Persons
                   Authorized to Receive Notices and Communications)


                                 March 14, 1997
- --------------------------------------------------------------------------------
              (Date of Event which Requires Filing this Statement)

If the filing person has previously filed a statement on Schedule 13G to report
the acquisition which is the subject of this Schedule 13D/A, and is filing this
schedule because of Rule 13D/A-1(b)(3) or (4), check the following space     .
                                                                       ---

Check the following space if a fee is being paid with the statement    .  (A
                                                                    ---
fee is not required only if the reporting person:  (1) has a previous statement
on file reporting beneficial ownership of more than five percent of the class
of securities described in Item 1; and (2) has filed no amendment subsequent
thereto reporting beneficial ownership of five percent or less of such class.)
(See Rule 13D/A-7.)

NOTE:  Six copies of this statement, including all exhibits, should be filed
with the Commission.  See Rule 13D/A-1(a) for other parties to whom copies are 
to be sent.

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities,
and for any subsequent amendment containing information which would alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
the Act but shall be subject to all other provisions of the Act (however, see
the Notes).
                        (Continued on following page(s))
<PAGE>

CUSIP 
No.  291345106                          13D/A

- --------------------------------------------------------------------------------
  1  Name of Reporting Person
     S.S. or I.R.S. Identification No. of Above Person

     AMERINDO INVESTMENT ADVISORS INC., a California corporation, AMERINDO 
     INVESTMENT ADVISORS, INC., a Panama corporation, ALBERTO W. VILAR AND 
     GARY A. TANAKA, who disaffirm the existence of any group and who are 
     sometimes collectively referred to as the "Reporting Persons."

- --------------------------------------------------------------------------------
  2  Check the Appropriate Box if a Member of a Group*            (a)   [ ]

                                                                  (b)   [ ]
- --------------------------------------------------------------------------------
  3  SEC Use Only

- --------------------------------------------------------------------------------
  4  Source of Funds*
     00

- --------------------------------------------------------------------------------
  5  Check Box if Disclosure of Legal Proceedings is Required           [ ]

- --------------------------------------------------------------------------------
  6  Citizenship or Place of Organization

     See Item 6 of separate cover pages for Reporting Persons

- --------------------------------------------------------------------------------
                 7   Sole Voting Power

    Number of        None
     Shares          
  Beneficially -----------------------------------------------------------------
    Owned By        
      Each       8   Shared Voting Power
    Reporting
     Person          1,107,300 shares in the aggregate for all Reporting Persons
      With           and as to all of which beneficial ownership is disclaimed

               -----------------------------------------------------------------
                 9   Sole Dispositive Power
 
                     None

               -----------------------------------------------------------------
                 10  Shared Dispositive Power 

                     1,107,300 shares in the aggregate for all Reporting Persons
                     and as to all of which beneficial ownership is disclaimed
                     
- --------------------------------------------------------------------------------
 11  Aggregate Amount Beneficially Owned By Each Reporting Person
                                      
     1,107,300 shares in the aggregate for all Reporting Persons and as to
     all of which beneficial ownership is disclaimed

- --------------------------------------------------------------------------------
 12  Check Box if the Aggregate Amount in Row (11) excludes Certain
     Shares*                                                            [X]

- --------------------------------------------------------------------------------
 13  Percent of Class Represented by Amount in Row (11)                  11.69%

- --------------------------------------------------------------------------------
 14  Type of Reporting Person*                                          IA, IN

- --------------------------------------------------------------------------------

                     *SEE INSTRUCTIONS BEFORE FILLING OUT!

                                     - 2 of 13 -





CUSIP 
No.  291345106                          13D/A

- --------------------------------------------------------------------------------
  1  Name of Reporting Person
     S.S. or I.R.S. Identification No. of Above Person

     AMERINDO INVESTMENT ADVISORS INC.
 
- --------------------------------------------------------------------------------
  2  Check the Appropriate Box if a Member of a Group*            (a)   [ ]

                                                                  (b)   [ ]
- --------------------------------------------------------------------------------
  3  SEC Use Only

- --------------------------------------------------------------------------------
  4  Source of Funds*
     00

- --------------------------------------------------------------------------------
  5  Check Box if Disclosure of Legal Proceedings is Required           [ ]

- --------------------------------------------------------------------------------
  6  Citizenship or Place of Organization

     California

- --------------------------------------------------------------------------------
                 7   Sole Voting Power

    Number of        None
     Shares          
  Beneficially -----------------------------------------------------------------
    Owned By   
      Each       8   Shared Voting Power
    Reporting    
     Person          660,000 shares, as to all of which beneficial ownership 
      With           is disclaimed
          
               -----------------------------------------------------------------
                 9   Sole Dispositive Power

                     None
 
               -----------------------------------------------------------------
                 10  Shared Dispositive Power 

                     660,000 shares, as to all of which beneficial ownership 
                     is disclaimed
                     
- --------------------------------------------------------------------------------
 11  Aggregate Amount Beneficially Owned By Each Reporting Person
                                      
     660,000 shares, as to all of which beneficial ownership is disclaimed

- --------------------------------------------------------------------------------
 12  Check Box if the Aggregate Amount in Row (11) excludes Certain
     Shares*                                                            [X]

- --------------------------------------------------------------------------------
 13  Percent of Class Represented by Amount in Row (11)                   6.97%

- --------------------------------------------------------------------------------
 14  Type of Reporting Person*                                              IA

- --------------------------------------------------------------------------------

                     *SEE INSTRUCTIONS BEFORE FILLING OUT!


                                     - 3 of 13 -


<PAGE>

CUSIP 
No.  291345106                          13D/A

- --------------------------------------------------------------------------------
  1  Name of Reporting Person
     S.S. or I.R.S. Identification No. of Above Person

     AMERINDO INVESTMENT ADVISORS, INC.

- --------------------------------------------------------------------------------
  2  Check the Appropriate Box if a Member of a Group*            (a)   [ ]

                                                                  (b)   [ ]
- --------------------------------------------------------------------------------
  3  SEC Use Only

- --------------------------------------------------------------------------------
  4  Source of Funds*
     00

- --------------------------------------------------------------------------------
  5  Check Box if Disclosure of Legal Proceedings is Required           [ ]

- --------------------------------------------------------------------------------
  6  Citizenship or Place of Organization

     Panama

- --------------------------------------------------------------------------------
                 7   Sole Voting Power

    Number of        None
     Shares          
  Beneficially  ----------------------------------------------------------------
    Owned By
      Each       8   Shared Voting Power
    Reporting  
     Person          447,300 shares, as to all of which beneficial ownership 
      With           is disclaimed  
        
                ----------------------------------------------------------------
                 9   Sole Dispositive Power
 
                     None

                ----------------------------------------------------------------
                 10  Shared Dispositive Power 

                     447,300 shares, as to all of which beneficial ownership 
                     is disclaimed

- --------------------------------------------------------------------------------
 11  Aggregate Amount Beneficially Owned By Each Reporting Person
                                      
     447,300 shares, as to all of which beneficial ownership is disclaimed

- --------------------------------------------------------------------------------
 12  Check Box if the Aggregate Amount in Row (11) excludes Certain
     Shares*                                                            [X]

- --------------------------------------------------------------------------------
 13  Percent of Class Represented by Amount in Row (11)                   4.72%

- --------------------------------------------------------------------------------
 14  Type of Reporting Person*                                              IA

- --------------------------------------------------------------------------------

                     *SEE INSTRUCTIONS BEFORE FILLING OUT!


                                     - 4 of 13 -

<PAGE>

CUSIP 
No.  291345106                          13D/A

- --------------------------------------------------------------------------------
  1  Name of Reporting Person
     S.S. or I.R.S. Identification No. of Above Person

     ALBERTO W. VILAR

- --------------------------------------------------------------------------------
  2  Check the Appropriate Box if a Member of a Group*            (a)   [ ]

                                                                  (b)   [ ]
- --------------------------------------------------------------------------------
  3  SEC Use Only

- --------------------------------------------------------------------------------
  4  Source of Funds*
     00

- --------------------------------------------------------------------------------
  5  Check Box if Disclosure of Legal Proceedings is Required           [ ]

- --------------------------------------------------------------------------------
  6  Citizenship or Place of Organization

     United States

- --------------------------------------------------------------------------------
                 7   Sole Voting Power

    Number of        None
     Shares                                          
  Beneficially  ----------------------------------------------------------------
    Owned By
      Each        8  1,107,300 shares, as to all of which beneficial ownership
    Reporting        is disclaimed
     Person
      With      ----------------------------------------------------------------
  
                  9  Sole Dispositive Power
 
                     None

                ----------------------------------------------------------------
                 10  Shared Dispositive Power 

                     1,107,300 shares, as to all of which beneficial ownership
                     is disclaimed

- --------------------------------------------------------------------------------
 11  Aggregate Amount Beneficially Owned By Each Reporting Person
                                      
     1,107,300 shares, as to all of which beneficial ownership is disclaimed

- --------------------------------------------------------------------------------
 12  Check Box if the Aggregate Amount in Row (11) excludes Certain
     Shares*                                                            [X]

- --------------------------------------------------------------------------------
 13  Percent of Class Represented by Amount in Row (11)                  11.69%

- --------------------------------------------------------------------------------
 14  Type of Reporting Person*                                              IN

- --------------------------------------------------------------------------------

                     *SEE INSTRUCTIONS BEFORE FILLING OUT!


                                     - 5 of 13 -
<PAGE>

CUSIP 
No.  291345106                          13D/A

- --------------------------------------------------------------------------------
  1  Name of Reporting Person
     S.S. or I.R.S. Identification No. of Above Person

     GARY A. TANAKA

- --------------------------------------------------------------------------------
  2  Check the Appropriate Box if a Member of a Group*            (a)   [ ]

                                                                  (b)   [ ]
- --------------------------------------------------------------------------------
  3  SEC Use Only

- --------------------------------------------------------------------------------
  4  Source of Funds*
     00

- --------------------------------------------------------------------------------
  5  Check Box if Disclosure of Legal Proceedings is Required           [ ]

- --------------------------------------------------------------------------------
  6  Citizenship or Place of Organization

     United States

- --------------------------------------------------------------------------------
                  7   Sole Voting Power

    Number of         None
     Shares          
  Beneficially  ----------------------------------------------------------------
    Owned By    
      Each        8   Shared Voting Power
    Reporting  
     Person           1,107,300 shares, as to all of which beneficial ownership 
      With            is disclaimed
          
                ----------------------------------------------------------------
                  9   Sole Dispositive Power
 
                      None

                ----------------------------------------------------------------
                  10  Shared Dispositive Power 

                      1,107,300 shares, as to all of which beneficial ownership 
                      is disclaimed

- --------------------------------------------------------------------------------
 11  Aggregate Amount Beneficially Owned By Each Reporting Person
                                      
     1,107,300 shares, as to all of which beneficial ownership is disclaimed

- --------------------------------------------------------------------------------
 12  Check Box if the Aggregate Amount in Row (11) excludes Certain
     Shares*                                                            [X]

- --------------------------------------------------------------------------------
 13  Percent of Class Represented by Amount in Row (11)                  11.69%

- --------------------------------------------------------------------------------
 14  Type of Reporting Person*                                              IN

- --------------------------------------------------------------------------------

                     *SEE INSTRUCTIONS BEFORE FILLING OUT!


                                     - 6 of 13 -

<PAGE>

CUSIP 
No.  291345106                          13D/A

ITEM 1.   Security and Issuer.
- -------   -------------------

The class of equity securities to which this statement relates is the 
Common Stock of Emisphere Technologies Inc. ("the Issuer"), whose principal 
executive offices are located at 15 Skyline Drive, Hawthorne, NY 10532.

ITEM 2.   Identity and Background.
- ------    -----------------------

          This statement is being filed by Amerindo Investment Advisors Inc., 
a California corporation whose principal executive offices are located at 
One Embarcadero Center, Suite 2300, San Francisco, California, 94111 
("Amerindo"), Amerindo Investment Advisors, Inc., a Panama corporation, whose 
principal executive offices are located at Edificio Sucre, Calle 48 Este, Bella 
Vista, Apartado 6277, Panama 5, Panama ("Amerindo Panama"), Alberto W. Vilar 
and Gary A. Tanaka.  Although this statement is being made jointly by Amerindo, 
Amerindo Panama, and Messrs. Vilar and Tanaka, each of them expressly 
disaffirms membership in any group under Rule 13D/A-5 under the Securities 
Exchange Act of 1934, as amended (the "Exchange Act"), or otherwise.  

          Amerindo is registered as an investment advisor under the Investment
Advisors Act of 1940, as amended.  Messrs. Alberto W. Vilar and Gary A. Tanaka, 
whose business addresses are the same as those set forth for Amerindo and each 
of whom is a U.S. citizen, are the only directors and executive officers of
Amerindo Panama.  They are also the only directors and executive officers of 
Amerindo, other than Mr. James H. Furey, Chief Operating Officer, and 
Mr. Joaquin Garcia-Larrieu, Chief Financial Officer. Mr. Furey and Mr. 
Garcia's business addresses are at Amerindo's offices at 399 Park Avenue, 
New York, New York 10022.  Amerindo, Amerindo Panama, and Messrs. Vilar and 
Tanaka are sometimes hereinafter collectively referred to as the "Reporting 
Persons."  Messrs. Vilar, Tanaka, Furey and Garcia are sometimes hereinafter 
collectively referred to as the "Other Named Individuals."

          During the last five Quarters, none of the Reporting Persons or Other 
Named Individuals has been convicted in a criminal proceeding (excluding traffic
violations or similar misdemeanors), nor has any such individual or entity
been a party to a civil proceeding of a judicial or administrative body of
competent jurisdiction as a result of which proceeding such individual or
entity was or is subject to a judgment, decree or final order enjoining
future violations of, or prohibiting or mandating activities subject to,
Federal or state securities laws or finding any violation with respect to
such laws.


ITEM 3.   Source and Amounts of Funds or Other Consideration.
- -------   --------------------------------------------------

          All purchases of the subject securities by the Reporting Persons
have been in the ordinary course of the respective businesses of Amerindo
and Amerindo Panama (collectively, the "Advisor Entities") as investment 
advisors.  Accordingly, the funds used to purchase the subject securities 
have been client funds pertaining to accounts under management. Purchases of 
the Issuer's securities by the Named Individuals would all be and have all 
been made with their personal funds, except that margin credit may also be, 
and may have been, employed.


                                     - 7 of 13 -
<PAGE>

ITEM 4.   Purpose of Transaction.
- -------   ----------------------

        All of the subject securities have been purchased by the Advisor
Entities in the ordinary course of their respective businesses as
investment advisors, and not with the purpose of effecting change or 
influencing the control of the issuer or in connection with or as a 
participant in any transaction having such purpose or effect, including 
any transaction subject to Rule 13D/A-3(b) under the Exchange Act.  
Additionally, because each of the Advisor Entities is obligated to act 
in the best interests of its respective clients and in accordance with 
the respective mandates of those clients, there is no agreement between 
or among any of the Reporting Persons to act together with respect to the 
Issuer or its securities, except that they may, from time to time and 
provided that transactions are otherwise being effected at the same time, 
aggregate orders for client accounts in order to receive more favorable 
trading terms.  Any of the subject securities acquired or which might in 
the future be acquired by any of the Named Individuals have been and would 
be acquired for investment and not with the purpose of effecting change or 
influencing the control of the issuer or in connection with or as a 
participant in any transaction having such purpose or effect, including 
any transaction subject to Rule 13D/A-3(b) under the Exchange Act. 


ITEM 5.  Interests in Securities of Issuer.
- -------  ---------------------------------

         (a)  See Exhibit "A" attached hereto for information setting forth for
each of the Reporting Persons and for each Named Individual the aggregate number
of shares of the Common Stock of Issuer beneficially owned by such person as of
March 14, 1997, and the percentage which such shares constitute of the total
number of shares outstanding, as reflected on Issuer's Form 10Q for the Quarter
Ending October 31, 1996, unless information has been obtained as of a later
date directly from the Issuer (with beneficial ownership determined as set forth
in Rule 13D/A-3 under the Exchange Act, but disclaimed except as set forth in 
the Exhibit).

          (b) Messrs. Vilar and Tanaka share voting and dispositive power
over all shares shown as owned by any of the Reporting Persons, however, each 
client of the Advisor Entities has the unilateral right to terminate the 
advisory arrangement with the Entity in question on notice which typically need 
not exceed 30 days.  Each of the Other Named Individuals has sole voting and 
dispositive power as to the shares shown in Exhibit "A" as owned by him.

          (c) The table contained in Exhibit "B" attached hereto sets forth for 
each of the Reporting Persons and Named Individuals information concerning all
acquisitions and dispositions of Issuer's Common Stock by any such person
during the period beginning on February 10, 1997, and ending on March 14, 1997, 
including (i) the date of the transaction (ii) whether the transaction 
was a purchase or sale, (iii) the number of shares involved, and (iv) the price 
per share at which the transaction was effected.  All transactions were 
effected on the open market.

          (d) The shares covered by this statement are all owned by clients
of the Advisor Entities.  No such person's interest in the securities included 
in this statement exceeds 5% of the class outstanding.

          (e) Inapplicable

                                     - 8 of 13 -

<PAGE>

ITEM 6.   Contracts, Arrangements, Understandings or
- ------    Relationships with Respect to Securities
          of the Issuer.
          ------------------------------------------

          Messrs. Vilar and Tanaka are the sole shareholders and directors
of each of the Advisor Entities.  As stated above, clients of those
Entities generally have the right to terminate their investment advisory
arrangements with those Entities on notice of 30 days or less.


ITEM 7.   Material to be Filed as Exhibits.
- ------    --------------------------------

          Inapplicable.

                                     - 9 of 13 -

<PAGE>


                                   SIGNATURES
                                   ----------

     After reasonable inquiry and to the best of our knowledge and belief, we
certify that the information set forth in this statement is true, complete
and correct.


                                   AMERINDO INVESTMENT ADVISORS INC.,
                                   a California corporation
                          

                                   By:  /s/ Alberto W. Vilar
                                        --------------------------------------
                                        ALBERTO W. VILAR, PRESIDENT



                                   AMERINDO INVESTMENT ADVISORS, INC.,
                                   a Panama corporation


                                   By:  /s/ Alberto W. Vilar
                                        --------------------------------------
                                        ALBERTO W. VILAR, DIRECTOR



                                        /s/ Alberto W. Vilar
                                        --------------------------------------
                                        ALBERTO W. VILAR


                                        /s/ Gary A. Tanaka
                                        --------------------------------------
                                        GARY A. TANAKA


                                     - 10 of 13 -

<PAGE>



                               EXHIBIT A

                       EMISPHERE TECHNOLOGIES INC.

                             COMMON STOCK

                               291345106


                            


     The following table sets forth for each of the Reporting Persons and
for each Other Named Individual the aggregate number of shares of the Common
Stock of the Issuer beneficially owned by such person as of March 14, 1997,
and the percentage which such shares constitute of the total number of
shares outstanding, as reflected on the Issuer's Form 10Q for the Quarter 
Ending October 31, 1996, unless based on more recent information obtained 
directly from the Issuer (with beneficial ownership determined as set forth in 
Rule 13D/A-3 under the Exchange Act, but disclaimed as set forth in the 
footnote):

          NAME                   NO. OF SHARES (1)       PERCENT OF CLASS
          ----                   -------------           ----------------

          Amerindo                    660,000                     6.97%

          Amerindo Panama             447,300                     4.72%

          Alberto W. Vilar          1,107,300                    11.69%

          Gary A. Tanaka            1,107,300                    11.69%

          James H. Furey                    0                     0.00%

          Joaquin Garcia                    0                     0.00%


_____________________________________

(1)  Messrs. Vilar and Tanaka, as the sole directors and shareholders of
each of the Advisor Entities, share voting and investment power as to all
shares shown as owned by the Advisor Entities, but they and the Advisor
Entities disclaim ownership of any of such shares.  Each client of the 
Advisor Entities has the unilateral right to terminate the advisory 
arrangement with the Entity in question on notice which typically need 
not exceed 30 days.


                                     - 11 of 13 -

<PAGE>



                              EXHIBIT B

                      EMISPHERE TECHNOLOGIES INC.

                            COMMON STOCK

                              291345106


     The following table sets forth for each of the Reporting Persons and Other
Named Individuals information concerning all acquisitions and dispositions
of the Issuer's Common Stock by any such person during the period beginning
on February 10, 1997, and ending on March 14, 1997, including (i) the date of 
the transaction (ii) whether the transaction was a purchase or sale, (iii) the 
number of shares involved, and (iv) the price per share at which the 
transaction was effected.  All transactions were effected on the open market.


                                 Type of         Number        Price
Name                 Date        Transaction     of Shares     per Share
- ----                 ----        -----------     ---------     ---------
Amerindo		02-11-97	Sell		20,000		23.250
Amerindo Panama	02-24-97	Sell		17,500		25.175
Amerindo Panama	02-27-97	Sell		25,000		25.375
Amerindo Panama	02-27-97	Sell		 5,200		25.291
Amerindo Panama	02-28-97	Sell		25,000		24.350
Amerindo Panama	03-14-97	Sell		 7,500		22.292





                                    - 12 of 13 -


<PAGE>


                                  EXHIBIT C

                           EMISPHERE TECHNOLOGIES INC.

                                 COMMON STOCK

                                  291345106

                                        
We hereby agree that the within Statement on Schedule 13D/A regarding our 
beneficial ownership of Common Stock is filed on behalf of each of us.


                                   AMERINDO INVESTMENT ADVISORS INC.,
                                   a California corporation
                          

                                   By:  /s/ Alberto W. Vilar
                                        --------------------------------------
                                        ALBERTO W. VILAR, PRESIDENT



                                   AMERINDO INVESTMENT ADVISORS, INC.,
                                   a Panama corporation


                                   By:  /s/ Alberto W. Vilar
                                        --------------------------------------
                                        ALBERTO W. VILAR, DIRECTOR



                                        /s/ Alberto W. Vilar
                                        --------------------------------------
                                        ALBERTO W. VILAR


                                        /s/ Gary A. Tanaka
                                        --------------------------------------
                                        GARY A. TANAKA


                                   - 13 of 13 -




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