EMISPHERE TECHNOLOGIES INC
10-Q, 1998-12-15
PHARMACEUTICAL PREPARATIONS
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                                   FORM 10-Q
                      SECURITIES AND EXCHANGE COMMISSION
                            WASHINGTON, D.C. 20549
                              ___________________

(Mark One)
          [X]  QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15 (d)
               OF THE SECURITIES EXCHANGE ACT OF 1934
               For the quarterly period ended October 31, 1998

                                      OR

          [ ]  TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE
               SECURITIES EXCHANGE ACT OF 1934
               For the transition period from ________ to ________


                        Commission file number 1-10615


                         EMISPHERE TECHNOLOGIES, INC.
            (Exact name of registrant as specified in its charter)


                   DELAWARE                       13-3306985
          (State or jurisdiction of            (I.R.S. Employer
        incorporation or organization)      Identification Number)


          765 Old Saw Mill River Rd.                 10591
             Tarrytown, New York                  (Zip Code)
            (Address of principal
              executive offices)

                                (914) 347-2220
             (Registrant's telephone number, including area code)


  (Former name, former address and former fiscal year, if changed since last
                                    report)


Indicate by  check mark  whether the  Registrant  (1)  has  filed  all  reports
required to  be files  by Section 13 or 15(d) of the Securities Exchange Act of
1934 during the preceding 12 months (or for such shorter period that Registrant
was required  to file  such reports)  and (2)  has been  subject to such filing
requirements for at least the past 90 days.     Yes   X    No
                                                    -----     -----

                     APPLICABLE ONLY TO CORPORATE ISSUERS

     The number  of shares  of the  Registrant's common  stock, $.01 par value,
     outstanding as of December 10, 1998 was: 10,981,694
<PAGE>
                         EMISPHERE TECHNOLOGIES, INC.

                               TABLE OF CONTENTS

                               October 31, 1998


Part I.   FINANCIAL INFORMATION

ITEM 1.   FINANCIAL STATEMENTS                                   Page
                                                                 ----
          Condensed Balance Sheets                                 3
          Condensed Statements of Operations                       4
          Condensed Statement of Stockholders' Equity              5
          Condensed Statements of Cash Flows                       6
          Notes to Condensed Financial Statements                  7

ITEM 2.   MANAGEMENT'S DISCUSSION AND ANALYSIS OF
          FINANCIAL CONDITION AND RESULTS OF OPERATIONS            9

Part II.  OTHER INFORMATION

ITEM 6.   EXHIBITS AND REPORTS ON FORM 8-K                        12


                                       2
<PAGE>
                         EMISPHERE TECHNOLOGIES, INC.
                           CONDENSED BALANCE SHEETS
                                  (UNAUDITED)

                                                     July 31,       October 31,
                                                       1998            1998
                      Assets:                      ------------    ------------
Current assets:
  Cash and cash equivalents                        $21,358,308     $18,079,989
  Marketable securities                             13,469,733      13,406,832
  Receivable due from Ebbisham                       7,710,056       5,043,935
  Prepaid expenses and other current assets            729,587         698,111
                                                   ------------    ------------
       Total current assets                         43,267,684      37,228,867

Equipment and leasehold improvements, at cost,
  net of accumulated depreciation and amortization   9,619,856      10,859,765
Deferred finance cost, net of accumulated
  amortization of $67,500 and $135,000,
  respectively                                         742,500         675,000
Other assets                                            59,970          59,970
                                                   ------------    ------------
       Total assets                                $53,690,010     $48,823,602
                                                   ============    ============

       Liabilities and Stockholders' Equity:
Current liabilities:
  Accounts payable                                 $   724,848     $   720,754
  Accrued compensation                                 266,000         266,000
  Accrued professional fees                            203,000         134,098
  Accrued interest expense                             168,750         337,500
  Accrued expenses                                     364,483         114,059
  Deferred revenue                                                     625,000
  Senior convertible notes, current portion          3,500,000       3,500,000
  Investment deficiency in Ebbisham Ltd.             6,583,670       2,744,438
                                                   ------------    ------------
       Total current liabilities                    11,810,751       8,441,849

Senior convertible notes                            10,000,000      10,000,000
Deferred lease liability                               598,111       1,824,544
                                                   ------------    ------------
       Total liabilities                            22,408,862      20,266,393

Commitments and contingencies
Stockholders' equity:
  Preferred stock, $.01 par value; 1,000,000
    shares authorized, none issued and outstanding
  Common stock, $.01 par value; 20,000,000 shares
    authorized; 11,037,238 shares issued
    (10,993,738 outstanding) at July 31, 1998;
    11,064,258 shares issued (11,020,758
    outstanding) at  October 31, 1998                  110,372         110,643
  Additional paid-in capital                        88,481,742      88,635,029
  Accumulated deficit                              (57,123,403)    (60,103,749)
  Accumulated other comprehensive income                 5,250         108,099
                                                   ------------    ------------
                                                    31,473,961      28,750,022
  Less, common stock held in treasury, at cost;
    43,500 shares                                     (192,813)       (192,813)
                                                   ------------    ------------
       Total stockholders' equity                   31,281,148      28,557,209
                                                   ------------    ------------
       Total liabilities and
         stockholders' equity                      $53,690,010     $48,823,602
                                                   ============    ============

See accompanying  notes to  financial statements.   The July 31, 1998 Condensed
Balance Sheet  data was derived from audited financial statements, but does not
include all disclosures required by generally accepted accounting principles.


                                       3
<PAGE>
                         EMISPHERE TECHNOLOGIES, INC.

                       CONDENSED STATEMENTS OF OPERATIONS

                                   (UNAUDITED)

                                                  For the three months
                                                   ended October 31,
                                             ------------------------------
                                                 1997              1998
                                             ------------      ------------
 Revenues:
   Contract research revenues                $ 1,715,660       $ 3,579,061
                                             ------------      ------------

 Costs and expenses:
   Research and development                    2,666,518         4,299,353
   Loss in Ebbisham Ltd.                         914,084         1,160,768
   General and administrative                    963,196         1,360,193
                                             ------------      ------------
        Total operating expenses               4,543,798         6,820,314
                                             ------------      ------------
        Operating loss                        (2,828,138)       (3,241,253)

 Other income and expenses:
   Investment income                             485,882           481,990
   Interest expense                                               (236,250)
   Rental income                                                    15,167
                                             ------------      ------------
                                                 485,882           260,907
                                             ------------      ------------
        Net loss                             $(2,342,256)      $(2,980,346)
                                             ============      ============

 Net loss per share, basic and diluted         $ (0.22)          $ (0.27)
                                               ========          ========



               See accompanying notes to the financial statements


                                       4
<PAGE>
                                      EMISPHERE TECHNOLOGIES, INC.

                                   STATEMENTS OF STOCKHOLDERS' EQUITY

                                              (UNAUDITED)

                              For the three months ended October 31, 1998
<TABLE>
<CAPTION>
                                                                         Accumulated
                                                                            Other         Common Stock
                           Common Stock       Additional                   Compre-      Held In Treasury                 Compre-
                       --------------------     Paid-in     Accumulated    hensive    ------------------                 hensive
                         Shares     Amount      Capital       Deficit      Income     Shares     Amount       Total        Loss
                       ----------  --------   -----------  ------------- -----------  ------  ----------  ------------ ------------
<S>                    <C>         <C>        <C>          <C>           <C>          <C>     <C>         <C>          <C>
Balance,
 July 31, 1998         11,037,238  $110,372   $88,481,742  $(57,123,403)   $  5,250   43,500  $(192,813)  $31,281,148

Sale of common stock
 under employee stock
 purchase plans and
 exercise of options       27,020       271       153,287                                                     153,558
Change in net
 unrealized gain
 (loss) on marketable                                                       102,849                           102,849  $   102,849
 securities
Net (loss)                                                   (2,980,346)                                   (2,980,346)  (2,980,346)
                       ----------  --------   -----------  ------------- -----------  ------  ----------  ------------ ------------
Balance,
 October 31, 1998      11,064,258  $110,643   $88,635,029  $(60,103,749)   $108,099   43,500  $(192,813)  $28,557,209  $(2,877,497)
</TABLE>


                               See accompanying notes to financial statements


                                       5
<PAGE>
                         EMISPHERE TECHNOLOGIES, INC.

                       CONDENSED STATEMENTS OF CASH FLOWS

                                   (UNAUDITED)

                Increase (Decrease) in Cash and Cash Equivalents


                                                        For the three months
                                                          ended October 31,
                                                     --------------------------
                                                         1997          1998
Cash flows from operating activities                 ------------  ------------
  Net loss                                           $(2,342,256)  $(2,980,346)
                                                     ------------  ------------
  Adjustments to reconcile net loss to net cash
    (used in) provided by operating activities:
      Loss in Ebbisham Ltd.                              914,084     1,160,768
      Depreciation                                       117,423       361,066
      Amortization of (premium) discount on
        marketable securities                             (1,524)       20,773
      Amortization of deferred financing costs                          67,500
      Increase in deferred lease liability               101,767     1,226,433
      Change in assets and liabilities:
        (Increase) decrease in receivable due         (1,090,661)    2,666,121
          from Ebbisham Ltd.
        (Increase) decrease in prepaid expenses          (21,852)       31,476
          and other current assets
        Increase in deferred revenue                                   625,000
        Decrease in accounts payable and accrued
          expenses                                       (27,186)     (160,506)
        Increase in accrued interest payable                           168,750
        Increase in investment in Ebbisham Ltd.                     (5,000,000)
                                                     ------------  ------------
          Total adjustments                               (7,949)    1,167,381
                                                     ------------  ------------
          Net cash used in operating activities       (2,350,205)   (1,812,965)
                                                     ------------  ------------
Cash flows from investing activities:
  Capital expenditures                                  (308,348)   (1,763,889)
  Purchase of marketable securities                   (3,555,577)     (855,023)
  Proceeds from sales of marketable securities         2,146,365     1,000,000
                                                     ------------  ------------
          Net cash used in investing activities       (1,717,560)   (1,618,912)
                                                     ------------  ------------
Cash flows from financing activities:
  Proceeds from exercise of options and employee
    stock purchases                                      223,262       153,558
                                                     ------------  ------------
          Net cash provided by financing activities      223,262       153,558
                                                     ------------  ------------
          Net decrease in cash and cash equivalents   (3,844,503)   (3,278,319)

Cash and cash equivalents, beginning of period        22,398,967    21,358,308
                                                     ------------  ------------
          Cash and cash equivalents, end of period   $18,554,464   $18,079,989
                                                     ============  ============
Supplemental disclosure of non-cash investing
  and financing activity:
    Capital expenditure in accounts payable                        $   101,000
                                                                   ===========

                See accompanying notes to financial statements


                                       6
<PAGE>
                         EMISPHERE TECHNOLOGIES, INC.
                    NOTES TO CONDENSED FINANCIAL STATEMENTS
                                       
1.   Interim Financial Statements:

     The interim Condensed Statements of Operations and Condensed Statements of
     Cash  Flows  for the  three  months  ended  October 31, 1997 and 1998, the
     Statement  of  Stockholders' Equity for the three months ended October 31,
     1998 and the Condensed Balance Sheets as of July 31, and October 31, 1998,
     of Emisphere Technologies, Inc.  (the "Company"),  have  been  prepared in
     accordance  with  the  instructions   to  Form  10-Q  and  Article  10  of
     Regulation  S-X.  Accordingly,  they do not  include  all  information and
     disclosures  necessary  for a  presentation  of  the  Company's  financial
     position,  results  of  operations  and  cash  flows  in  conformity  with
     generally accepted accounting principles.  In the  opinion of  management,
     these  financial  statements reflect all  adjustments, consisting  only of
     normal  recurring  accruals,  necessary  for  a fair  presentation of  the
     Company's  financial position, results of  operations and  cash flows  for
     such  periods. The  results of operations for  any interim  period are not
     necessarily indicative of the results for  the full year.  These financial
     statements should be read in conjunction with the financial statements and
     notes thereto contained in the Company's  Annual Report  on Form  10-K for
     the fiscal year ended July 31, 1998.

2.   Ebbisham Limited:

     During October  1996, Ebbisham  Limited, the  equally owned  joint venture
     formed by  the Company  and Elan  Corporation plc  ("Ebbisham"), commenced
     operations.   The Company  accounts for  its  investment  in  Ebbisham  in
     accordance with  the  equity  method  of  accounting.    Since  Ebbisham's
     inception  (September  1996),  the  Company  has  contributed  capital  to
     Ebbisham of approximately $5,010,000.

     Contract revenue  from Ebbisham,  with respect to services provided by the
     Company to  Ebbisham, is  recognized as the related services are rendered.
     Such revenue for the three  months ended October 31, 1998 and 1997 totaled
     approximately $2,302,000 and $1,091,000, respectively.

     Selected financial  data of  Ebbisham as  of October  31, 1998 and for the
     three months ended October 31, 1997 and 1998 is as follows:


                                            October 31, 1998
         Balance Sheet Data                 ----------------

           Cash                               $  4,222,000

           Accounts payable                   $  5,211,000

           Subordinated debt                  $ 14,500,000

           Stockholders' deficit              $(15,489,000)


                                              Three Months Ended
                                        ------------------------------
                                        October 31,        October 31,
                                            1997              1998
      Statement of Operations Data      ------------      ------------

       Total Revenue                    $    26,000       $    30,000

       Total Expenses                    (1,406,000)       (2,351,000)

            Net Loss                    $(1,380,000)      $(2,321,000)


                                       7
<PAGE>
3.   Net Loss Per Share:

     The Company's  basic net  loss per  share amounts  have been  computed  by
     dividing net  loss  by  the  weighted  average  number  of  Common  Shares
     outstanding.   For the  three months ended October 31, 1998, and 1997, the
     Company reported  net losses  and, therefore,  no common stock equivalents
     were included  in the computation of diluted net loss per share since such
     inclusion would  have been  antidilutive.   The calculations  of basic and
     diluted net loss per share are as follows:


                              Net Loss             Shares          Per Share
                             (Numerator)        (Denominator)        Amount
                             ------------       -------------      ---------
     Three months ended
     October 31, 1998-
     basic and diluted       $(2,980,346)         11,004,808        $(0.27)
                             ============         ==========        =======
     Three months ended
     October 31, 1997-
     basic and diluted       $(2,342,256)         10,695,469        $(0.22)
                             ============         ==========        =======


     Options and  shares of  common stock issuable upon conversion of Notes and
     related accrued  interest which  have been  excluded from  the diluted per
     share amount  because their  effect would  have been antidilutive, include
     the following:

                                     1997                        1998
                             ---------------------       ---------------------
                                          Weighted                    Weighted
                                           average                     average
                                          exercise                    exercise
                              Number        price         Number        price
                             ---------    --------       --------     --------
     Options with
     exercise prices
     below the average
     fair market value
     of the Company's
     common stock
     for the respective
     period                  4,213,262      $10.74        316,588        $4.18

     Options with
     exercise prices
     above the average
     fair market value
     of the Company's
     common stock
     for the respective
     period                     87,400       $21.56     3,978,199       $11.14

     Notes and
     accrued interest                                   1,033,750


4.   Adoption of Statement of Financial Accounting Standards No. 130

     The Company  has adopted  Statement of  Financial Accounting Standards No.
     130, Reporting  Comprehensive Income ("SFAS No. 130").  Comprehensive loss
     represents the  change in  net assets  of a  business enterprise  during a
     period from transactions and other events and circumstances from non-owner
     sources.  Comprehensive loss of the Company includes net loss adjusted for
     the change  in net  unrealized gain or loss on marketable securities.  The
     net effect  of income  taxes on  comprehensive loss  is immaterial.    The
     disclosures required  by SFAS  No. 130  for the three months ended October
     31, 1998 have been included in the Statement of Stockholders' Equity.  For
     the three  months ended  October 31,  1998, and  1997, the  components  of
     comprehensive loss were:

                                               1997               1998
                                           ------------       ------------
     Net Loss                              $(2,342,256)       $(2,980,346)

     Change in net unrealized gain
       on marketable securities                 (1,534)           102,849

          Total comprehensive loss         $(2,343,790)       $(2,877,497)


                                       8
<PAGE>
ITEM 2. MANAGEMENT'S  DISCUSSION  AND  ANALYSIS  OF  FINANCIAL  CONDITIONS  AND
        RESULTS OF OPERATIONS.

               SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS

          Certain statements  under the  caption "Management's  Discussion  and
Analysis of  Financial Conditions  and Results  of Operations" and elsewhere in
this report  on Form  10-Q constitute  "forward-looking statements"  within the
meaning of  the Private  Securities  Litigation  Reform  Act  of  1995.    Such
forward-looking statements  involve known  and unknown risks, uncertainties and
other factors  which may  cause the actual results, performance or achievements
of the Company to be materially different from any future results, performance,
or achievements  expressed or implied by such forward-looking statements.  Such
factors include,  among others,  the following: uncertainties related to future
test results  and viability  of the  Company's product candidates, which are in
the early stages of development; the need to obtain regulatory approval for the
Company's product  candidates; the  Company's dependence  on partnerships  with
pharmaceutical companies  to develop,  manufacture and  commercialize  products
using the Company's drug delivery technologies; the Company's dependence on the
success of  its joint  venture with  Elan  Corporation  plc  ("Elan")  for  the
development and  commercialization of  an oral heparin and low molecular weight
heparin product,  its strategic  alliance with  Eli Lilly and Company ("Lilly")
for the  development and  commercialization of  certain of  Lilly's therapeutic
proteins and  its research collaboration with Novartis Pharma AG to investigate
the Company's  technology for oral delivery of two selected Novartis compounds;
the risk  of technological obsolescence and risks associated with the Company's
highly competitive  industry; the Company's dependence on others to manufacture
the Company's  chemical compounds;  the risk  of product  liability and  policy
limits of  product liability  insurance; potential liability for human clinical
trials; the  Company's dependence  on key  personnel; the quality, judgment and
strategic decisions  of management  and other personnel; uncertain availability
of third-party  reimbursement for  commercial  medical  products;  and  general
business and economic conditions; and other factors referenced in the Company's
report on Form 10-K for the fiscal year ended July 31, 1998.

General

     Emisphere is  a  drug  delivery  company  focused  on  the  discovery  and
application of  proprietary synthetic  chemical compounds  that enable the oral
delivery of  therapeutic  macromolecules  and  other  compounds  that  are  not
currently deliverable  by oral means.  Since its inception in 1986, the Company
has devoted  substantially all  of its  efforts and  resources to  research and
development conducted  on  its  own  behalf  and  through  collaborations  with
corporate partners  and academic  research institutions.   The  Company has  no
product sales  to date.  The major sources of the Company's working capital has
been proceeds  from its  initial public  offering  in  1989,  a  second  public
offering in  1993, a  third public  offering in 1997, private equity financing,
issuance to  an affiliate of Elan Corporation plc of stock and warrants in 1995
and subsequent  exercise of  the  warrants  in  April  1998,  reimbursement  of
expenses and other payments from corporate partners, the registered sale of one
million shares  of common  stock to  two institutional  investors in  1996, the
issuance on  May 1,  1998 of  three year,  $13,500,000 aggregate  principal, 5%
senior convertible  notes, and  income earned  on the  investment of  available
funds. The  Company's operations are not significantly affected by inflation or
seasonality.


Results of Operations

     The Company  has since  its inception  generated significant  losses  from
operations.   The Company  does not  expect to  achieve  profitability  in  the
foreseeable future.   Profitability  will ultimately  depend on  the  Company's
ability to  develop its  lead products in conjunction with Ebbisham, Lilly, and
Novartis, or  to develop  other products  in conjunction  with other  partners.
There can  be no  assurance that  the  development  will  be  completed  or  if
completed, any regulatory agency will approve the final product.  Even if final
products are  developed and  approved, there is no assurance that sales will be
sufficient to  achieve profitability.   If  development of such products is not
achieved or  approval not  granted, the  Company's prospects will be materially
affected.


                                       9
<PAGE>
     The ability of the Company to reduce its operating losses in the near term
will be  dependent upon,  among  other  things,  its  ability  to  attract  new
pharmaceutical and  other companies  who are  willing to provide funding to the
Company for a portion of the Company's research and development with respect to
specific projects.  While the Company is constantly engaged in discussions with
pharmaceutical and  other companies, there can be no assurance that the Company
will enter  into any  additional agreements or that the agreements will provide
research and development revenues to the Company.


Three Months Ended October 31, 1998 vs. Three Months Ended October 31, 1997:

     For the  three months  ended October  31,  1998,  the  Company  recognized
$3,579,000 of  contract research  revenue compared  to $1,716,000  of  contract
research revenues for the three months ended October 31, 1997.  The majority of
contract research revenue for the three months ended October 31, 1998 consisted
of revenues from Ebbisham Ltd. of $2,300,000 and research funding payments from
Lilly and  Novartis.   For the  three months  ended October  31, 1997, contract
revenue consisted  of revenues  from Ebbisham  Ltd. of $1,091,000 and a payment
from Lilly.

     Total operating  expenses for  the fiscal  quarter ended  October 31 1998,
increased by  approximately $2,277,000  or 50%,   as  compared  to  the  fiscal
quarter ended October 31, 1997.  The details of this increase are as follows:

     Research and  development costs  increased by approximately $1,633,000, or
61%, in  the fiscal  quarter ended  October 31, 1998, as compared to the fiscal
quarter ended  October 31,  1997.   This increase  is  mainly  attributable  to
increased  personnel  and  laboratory  supply  costs  in  connection  with  the
collaborations with  Lilly, Novartis  and the  ongoing clinical trials work for
heparin.   The Company  also experienced  an increase  in  funding  of  outside
consultants and  universities engaged  to conduct  studies to  help advance the
Company's  scientific   research  efforts,  perform  services  related  to  the
manufacturing of  the Company's  carriers, and consult on the Company's ongoing
clinical studies  with heparin.   The  Company also  experienced an increase in
rent and  operating   expense in  connection with   a  new lease for laboratory
space.   The Company  believes that  this level  of  research  and  development
spending  will  continue  for  the  foreseeable  future  and  may  increase  if
operations are expanded.

     The loss  in Ebbisham Ltd. increased by approximately $247,000, or 27%, in
the fiscal  quarter ended  October 31,  1998, as compared to the fiscal quarter
ended October  31, 1997.   This  increase is  attributable  to  increased  cost
associated  with  the  ongoing  clinical  development  of  heparin.  The  costs
associated with  Ebbisham may  increase substantially depending upon the agreed
timing and scope of future research and development efforts.

     General and  administrative expenses  increased by approximately $397,000,
or 41%, in the fiscal quarter ended October 31, 1998, as compared to the fiscal
quarter ended  October 31,  1997.   This increase  is primarily  the result  an
increase in  personnel and  related expenses  associated with  an  increase  in
administrative staff  positions, of  costs associated with the ongoing computer
consulting to improve the Company's information system and  rent and  operating
expense in connection with a new lease for office  space.  This  was  partially
offset by a decrease in legal and professional fees paid in connection with the
application and issuance of patents on the Company's technology.

     As a result of these factors, the Company's operating loss for the quarter
ended October  31, 1998  increased by  $413,000, or  15%, as  compared  to  the
quarter ended  October 31,  1997.   The Company  does not expect to generate an
operating profit,  and may  possibly generate larger losses, in the foreseeable
future.

     The Company's  other income and expenses for the quarter ended October 31,
1998 decreased  by $225,000,  or 46%,  from the  quarter October  31, 1997. The
decrease is  primarily the result of interest expense which the Company accrued
on $13,500,000,  5% senior convertible notes due May 1, 2001and amortization of
deferred financing costs incurred in obtaining the notes.

     Based on the above, the Company sustained a net loss for the first quarter
of fiscal 1999 of $2,980,000, a 27% increase over the 1998 fiscal first quarter
loss of $2,342,000.

Liquidity and Capital Resources

     As of  October 31,  1998 the  Company had working capital of approximately
$28,787,000.   Total cash,  cash equivalents  and  marketable  securities  were
approximately $31,487,000,  a decrease  of $3,341,000 compared to the Company's
position at  July  31,  1998.    The  decrease  in  the  Company's  cash,  cash
equivalents and  marketable  securities  was primarily due to cash used to fund
capital expenditures  of $1.8 million and first quarter 1999 operations of $1.8
million.  The decrease  was partially  offset by proceeds  from the exercise of
options.


                                       10
<PAGE>
     The  Company  expects  to  continue  to  incur  substantial  research  and
development expenses associated with the development of the Company's oral drug
delivery system.   As  a result of the ongoing research and development efforts
of the  Company, management  believes that  the Company  will continue to incur
operating losses  and that,  potentially, such  losses  could  increase.    The
Company expects  to need  substantial resources  to continue  its research  and
development efforts.  In addition, the Company is obligated to fund one-half of
Ebbisham's  future  cash  needs  upon  the  venture's  request.    The  Company
anticipates that its share of the funding requirements will be $10,000,000 over
the  next  twelve  months.   In August 1998, the Company  loaned  Ebbisham Ltd.
$5,000,000 to cover past costs  incurred  by Ebbisham Ltd.  The Company expects
the research funding received from Lilly  and Novartis to approximate the costs
to be incurred by the Company in connection with the development of each of the
Company's  projects.  Under present operating  assumptions, the Company expects
that cash, cash equivalents and marketable  securities will be adequate to meet
its liquidity and capital  requirements  through  fiscal 2000.  Thereafter, the
Company  would  need to seek  additional  funds,  primarily in  the public  and
private equity markets and, to the extent necessary and available, through debt
financing.  The Company has no firm  agreements with respect to any  additional
financing  and  there  can  be  no  assurance that the Company would be able to
obtain  adequate  funds  on  acceptable  terms.   If adequate  funds  were  not
available, the Company would be required  to delay,  scale  back,  or eliminate
one or more of its  research  and  development  programs, or  obtain  funds, if
available, through arrangements with collaborative partners or others  that may
require the Company to  relinquish  rights  to  certain  of  its  technologies,
product  candidates,  or  products   that  the  Company  would  not   otherwise
relinquish.   The  Company  does  not maintain  any credit lines with financial
institutions.

Year 2000 Compliance

     The "Year  2000" problem  relates to  many currently  installed computers,
software, and other equipment that relies on embedded technology (collectively,
"Business systems").   These Business systems are not capable of distinguishing
21st century  dates from  20th century  dates.   As a  result, in less than two
years, Business  systems used  by many  companies, in  a very  wide variety  of
applications, will  experience operating difficulties unless they are modified,
upgraded, or  replaced to  adequately process information involving, related to
or dependent upon the century change.  If a Business system used by the Company
or a third party dealing with the Company fails because of the inability of the
Business system  to properly read a 21st century date, the results could have a
material adverse effect on the Company.
     
     The Company  recognizes the  need to  ensure its  operations will  not  be
adversely impacted by Year 2000 Business systems failures and has established a
team to  address Year  2000 risk.  The team is reviewing the Company's internal
infrastructure and  believes that  it has  identified substantially  all of the
major Business  systems used  in connection  with its internal operations.  The
Company has  commenced the  process of  identifying and  correcting  the  major
Business systems  that may  need to  be modified,  upgraded, or  replaced,  and
expects to complete this process, along with remedial actions before the end of
fiscal 1999.   Costs  incurred to  date to correct Year 2000 problems have been
immaterial.   The Company  estimates the  total cost  to complete  any required
modifications, upgrades,  or replacements of affected Business systems will not
have a  material impact  on the  Company's business  or results  of operations.
This estimate  is being  monitored  and  will  be  revised,  if  necessary,  as
additional information becomes available.
     
     The Company also recognizes the risk that suppliers of products, services,
and collaborators with whom the Company transacts business on a worldwide basis
may not  comply with  Year 2000 requirements.  The Company has initiated formal
communications with  significant suppliers  and collaborators  to determine the
extent to  which the  Company is  vulnerable if  these third  parties  fail  to
remediate their own Year 2000 issues.  The review is ongoing and the Company is
unable to  determine, at  this time, the probability that any material supplier
or collaborator  will not  be able to correct any Year 2000 problem in a timely
manner.   In the  event any  such third parties cannot provide the Company with
products, services,  or continue  the  collaborations  with  the  Company,  the
Company's results of operations could be materially adversely affected.
     
     Based on  the above,  the Company  has  yet  to  develop  a  comprehensive
contingency plan  with respect  to the  Year 2000  problem.   The Company  will
continue to  monitor its  own Business  systems and,  to the  extent  possible,
evaluate the Business systems of its third party suppliers and collaborators to
ensure progress  on this  critical matter.   However, if the Company identifies
significant risk  related to the Year 2000 compliance or progress deviates from
anticipated timelines,  the Company  will develop  contingency plans  as deemed
necessary at that time.
     
     THE DISCUSSION OF THE COMPANY'S EFFORTS, ESTIMATES, AND CONCLUSIONS HEREIN
CONTAIN FORWARD-LOOKING STATEMENTS AND ARE BASED ON MANAGEMENT'S BEST ESTIMATES
OF FUTURE EVENTS. THE COMPANY?S ABILITY TO ACHIEVE YEAR 2000 COMPLIANCE AND THE
LEVEL OF  INCREMENTAL COSTS  ASSOCIATED THEREWITH,  COULD BE ADVERSELY IMPACTED
BY, AMONG OTHER THINGS, THE AVAILABILITY AND COST OF MODIFICATIONS, OUR ABILITY
TO DISCOVER  AND CORRECT  THE POTENTIAL  YEAR 2000  PROBLEM, AND  UNANTICIPATED
PROBLEMS IDENTIFIED IN THE ONGOING COMPLIANCE REVIEW.


                                       11
<PAGE>
Part II.  OTHER INFORMATION


     (a)  Reports on Form 8-K

     During the  period covered  by this report, the registrant filed a Current
Report  on  Form  8-K  dated  October  1,  1998  reporting  Item  4  Change  in
Registrant's Certifying Accountants and including no financial statements.

                                   SIGNATURE



Pursuant to the requirement of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned thereunto duly authorized.



                                        Emisphere Technologies, Inc.

Dated:   December 15, 1998              by /s/ Joseph D. Poveromo
                                        ----------------------------
                                        Joseph D. Poveromo, C.P.A.
                                        Controller (Principal Financial
                                        and Accounting Officer)

                                       12

<TABLE> <S> <C>

<ARTICLE> 5
<LEGEND>
This Schedule contains summary financial information extracted from the
Financial Statements of Emisphere Technologies, Inc. at October 31, 1998
and is qualified in its entirety by reference to such Financial
Statements.
</LEGEND>
       
<S>                             <C>
<PERIOD-TYPE>                   3-MOS
<FISCAL-YEAR-END>                          JUL-31-1999
<PERIOD-START>                             AUG-01-1998
<PERIOD-END>                               OCT-31-1998
<CASH>                                      18,079,989
<SECURITIES>                                13,406,832
<RECEIVABLES>                                5,043,935
<ALLOWANCES>                                         0
<INVENTORY>                                          0
<CURRENT-ASSETS>                            37,228,867
<PP&E>                                      15,434,076
<DEPRECIATION>                               4,574,311
<TOTAL-ASSETS>                              48,823,602
<CURRENT-LIABILITIES>                        6,770,743
<BONDS>                                     10,000,000
                                0
                                          0
<COMMON>                                       110,643
<OTHER-SE>                                  28,446,566
<TOTAL-LIABILITY-AND-EQUITY>                48,823,602
<SALES>                                              0
<TOTAL-REVENUES>                             3,579,061
<CGS>                                                0
<TOTAL-COSTS>                                6,820,314
<OTHER-EXPENSES>                              (260,907)
<LOSS-PROVISION>                                     0
<INTEREST-EXPENSE>                             236,250
<INCOME-PRETAX>                             (2,980,346)
<INCOME-TAX>                                         0
<INCOME-CONTINUING>                         (2,980,346)
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                                (2,980,346)
<EPS-PRIMARY>                                    (.27)
<EPS-DILUTED>                                    (.27)
        

</TABLE>


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