EMISPHERE TECHNOLOGIES INC
424B3, 1999-06-25
PHARMACEUTICAL PREPARATIONS
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                                                 Rule 424(b)(3) and (c)
                                               Registration No. 333-52461

            Prospectus Supplement to Prospectus dated May 19, 1998


                                168,264 Shares

                         EMISPHERE TECHNOLOGIES, INC.

                                 Common Stock



    This Prospectus  Supplement relates  to the offer and sale of up to 168,264
shares (the  "Shares") of  the Common  Stock, par  value $.01  per  share  (the
"Common Stock"),  of Emisphere  Technologies, Inc.  (the "Company")  by certain
persons listed  under the  caption "Selling  Shareholders"  (collectively,  the
"Selling Shareholders")  that may  be acquired from time to time by the Selling
Shareholders upon  conversion of  the Company's  5% Senior  Secured Convertible
Notes due  1999 (the "Notes") and payment of interest on the Notes in shares in
lieu of cash.

    While the Selling Shareholders have not advised the Company of any specific
plans  for  the  distribution  of  the  Shares,  it  is  anticipated  that  the
distribution of  the Shares  may be  effected from  time to time by the Selling
Shareholders in  one or  more transactions  for their  own accounts  (which may
include block  transactions) in  the over-the-counter  market,  on  the  Nasdaq
National Market  or on  any exchange  on which  the Common  Stock may  then  be
listed, in  negotiated transactions,  through the  writing of options on shares
(whether such  options are  listed on  an options  exchange or otherwise), or a
combination of  such methods  of sale, at fixed prices which may be changed, at
market prices  prevailing at  the time  of sale,  at  prices  related  to  such
prevailing market prices or at negotiated prices.  The Selling Shareholders may
effect such  transactions by  selling shares  to or through broker-dealers, and
such  broker-dealers  may  receive  compensation  in  the  form  of  discounts,
concessions or  commissions from the Selling Shareholders and/or the purchasers
of shares for whom such broker-dealers may act as agent or to whom they sell as
principal, or  both (which  compensation as to a particular broker-dealer might
be in  excess of  customary commissions).   The  Selling Shareholders  and  any
participating brokers and dealers may be deemed to be "underwriters" as defined
in the Securities Act of 1933, as amended (the "Securities Act").  See "Selling
Shareholders".

    The Common  Stock is  quoted on the Nasdaq National Market under the symbol
"EMIS".   The last sale price of the Common Stock on June 22, 1999, as reported
on the Nasdaq National Market, was $7.25 per share.

    All expenses  of registration  incurred in  connection herewith  are  being
borne by  the Company, but all selling and other expenses incurred by a Selling
Shareholder will  be borne  by the  Selling Shareholder.   None of the proceeds
from the sale of the Shares will be received by the Company.

 THIS OFFERING INVOLVES A HIGH DEGREE OF RISK.  SEE "RISK FACTORS" STARTING ON
                           PAGE 4 OF THE PROSPECTUS.

      THESE SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE SECU-
          RITIES AND EXCHANGE COMMISSION OR ANY STATE SECURITIES COM-
             MISSION NOR HAS THE SECURITIES AND EXCHANGE COMMISSION
               OR ANY STATE SECURITIES COMMISSION PASSED UPON THE
                    ACCURACY OR ADEQUACY OF THIS PROSPECTUS.
                       ANY REPRESENTATION TO THE CONTRARY
                             IS A CRIMINAL OFFENSE.

            The date of this Prospectus Supplement is June 24, 1999

<PAGE>
                INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE

    In addition  to the  documents referred to under "Documents Incorporated by
Reference" in  the accompanying  Prospectus, the following documents heretofore
filed by  the Company  with the  Commission pursuant  to the  Exchange Act  are
incorporated by reference in this Prospectus Supplement:

  (1) Annual Report on Form 10-K for the fiscal year ended July 31, 1998;

  (2) Quarterly Report on Form 10-Q for the quarter ended October 31, 1998;

  (3) Quarterly Report on Form 10-Q for the quarter ended January 31, 1999; and

  (4) Quarterly Report on Form 10-Q for the quarter ended April 30, 1999.


               SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS

    Certain statements  included in  or  incorporated  by  reference  into  the
Prospectus  and   this  Prospectus   Supplement   constitute   "forward-looking
statements" within  the meaning of the Private Securities Litigation Reform Act
of 1995  (the "Reform Act").  Such forward-looking statements involve known and
unknown risks,  uncertainties and  other factors  which may  cause  the  actual
results, performance or achievements of the Company, or industry results, to be
materially different  from any  future results,  performance,  or  achievements
expressed or implied by such forward-looking statements.  Such factors include,
among others,  the  following:    general  economic  and  business  conditions;
competition; the  Company's  dependence  on  other  companies  to  develop  and
commercialize products using the Company's technologies; uncertainty of results
of pre-clinical  and clinical  testing; risk of technological obsolescence; the
Company's dependence  on other companies to manufacture the Company's products;
risk of  product liability and liability for human clinical trials; uncertainty
of health  care reform  and third party reimbursement; the Company's dependence
on patents  and proprietary rights; changes in business strategy or development
plans; quality  of management;  availability, terms  and deployment of capital;
business  abilities  and  judgment  of  personnel;  availability  of  qualified
personnel; changes  in, or  the failure to comply with, government regulations;
failure to  obtain regulatory  approval for  the Company's  products; and other
factors referenced in the Prospectus and this Prospectus Supplement.



                                          -2-

<PAGE>
                             SELLING SHAREHOLDERS


     The table  below sets forth information regarding the Selling Shareholders
as of the date of this Prospectus Supplement as to (i) the name of each Selling
Shareholder (none  of which  have had  positions,  offices  or  other  material
relationships with the Company during the past three years), (ii) the number of
shares of the Common Stock owned beneficially or of record by each such Selling
Shareholder, (iii)  the number  of shares  of the  Common Stock  being  offered
hereby from  time to  time by  such Selling  Shareholder and (iv) the number of
shares of  the Common  Stock to  be owned  by such  Selling  Shareholder  after
completion of  the offering, assuming all the Shares being offered from time to
time hereby are sold.

     The Shares  being offered  hereby  by  the  Selling  Shareholders  may  be
acquired, from  time to  time, upon  the  conversion  of  $2,647,604  aggregate
principal amount of the Notes and the payment by the Company of interest on the
Notes in  the form of Common Stock in lieu of cash.  The Notes were acquired by
the Selling  Shareholders from  the Company  in a private placement transaction
pursuant to  certain Note  Purchase Agreements dated as of May 1, 1998 and were
amended by  certain Amendment  Agreements dated as of June 24, 1999.  The Notes
can be converted in whole or in part at any time at a conversion price equal to
the lowest  five-day value  based on  the average  of the  high and low trading
price of the Common Stock as reported on the Nasdaq National Market for each of
the five  consecutive trading days immediately preceding the date of conversion
provided that  the conversion  price may  in no  event be lower than $16.00 per
share or higher than $22.00 per share.

     In  accordance   with  registration   rights  granted   to   the   Selling
Shareholders, the  Company has  filed with the Commission, under the Securities
Act, a  Registration Statement  on Form  S-3, of  which the Prospectus and this
Prospectus Supplement  form a  part, with  respect to  the resale of the Shares
from time  to time  on the  Nasdaq National  Market or  in privately-negotiated
transactions and has agreed to prepare and file such amendments and supplements
to the  Registration Statement  as may  be necessary  to keep such Registration
Statement effective  until the  Shares are  no longer required to be registered
for the sale thereof by the Selling Shareholders.

                                                                 Ownership
                                     Number of      Number     After Offering
                                    Shares Owned  of Shares  ------------------
                                      Prior to      Being     Number   Percent
Name of Selling Shareholder         Offering(1)   Offered(4) of Shares of Class
- ----------------------------------  ------------  ---------- --------- --------
Delta Opportunity Fund, Ltd.(2)(3)      149,140     150,545        -        -
OTATO Limited Partnership(3)             17,554      17,719        -        -
___________________________
(1)Represents the respective number of shares beneficially owned on the date of
   this Prospectus Supplement  based on  the principal amount of the Notes plus
   accrued interest thereon to such date.   Pursuant to the terms of the Notes,
   a Selling  Shareholder  may  not  convert  any  portion of the Notes if such
   conversion would increase such Selling Shareholder's beneficial ownership of
   the  Common  Stock  (other  than those shares  deemed  owned  because of the
   ownership of the remaining portion of the Notes) to in excess of 4.9% of the
   Common Stock outstanding.
(2)Diaz &  Altschul Advisors,  LLC, a  New York limited liability company ("D&A
   Advisors), serves  as investment  advisor to  Delta Opportunity  Fund,  Ltd.
   ("Delta") and  may be  deemed to  share beneficial  ownership of  the shares



                                          -3-

<PAGE>
   beneficially owned  by Delta  by reason  of shared  power to  dispose of the
   portion  of  the  Shares  beneficially  owned  by  Delta.  D&A  Advisors  is
   controlled by Diaz & Altschul Group, LLC ("D&A Group"). D&A Advisors and D&A
   Group  disclaim   beneficial  ownership   of  the   portion  of  the  Shares
   beneficially owned by Delta.
(3)An affiliate of OTATO  Limited  Partnership  serves  as a trading consultant
   to Delta  and may  be deemed to share beneficial ownership of the portion of
   the Shares  beneficially owned by Delta by reason of shared power to dispose
   of the Shares beneficially owned by such Selling Shareholder. Such affiliate
   disclaims beneficial ownership of such portion of the Shares.
(4)The number of shares offered exceeds the number of shares beneficially owned
   on the date of this Prospectus Supplement  because the number of shares that
   a Selling Shareholder  may  acquire  upon  conversion  of the Notes could be
   higher based on the amount of accrued interest at the time of conversion.



                                          -4-

<PAGE>
  No   person    is   authorized   in
connection  with  the  offering  made
hereby to  give any information or to
make any representation not contained
or incorporated  by reference in this
Prospectus   Supplement,    and   any                168,264 shares
information  or   representation  not
contained or incorporated herein must
not be  relied upon  as  having  been
authorized  by  the  Company  or  the
Selling    Shareholders.         This
Prospectus   Supplement    does   not
constitute an  offer  to  sell  or  a          EMISPHERE TECHNOLOGIES, INC.
solicitation of  an offer  to buy  by
any person  in  any  jurisdiction  in
which it  is unlawful for such person
to make  such offer  or solicitation.
Neither   the    delivery   of   this                 Common Stock
Prospectus Supplement at any time nor           par value $.01 per share
any sale  made hereunder  shall under
any  circumstance   imply  that   the
information   contained   herein   is
correct as  of any date subsequent to
the date hereof.

             __________

                                                      _____________
          TABLE OF CONTENTS
                                                  PROSPECTUS SUPPLEMENT
        Prospectus Supplement                         _____________
                             Page
Incorporation of Certain
  Documents by Reference....   2
Selling Shareholders........   3

             Prospectus                               June 24, 1999
                             Page
Available Information.......   2
Incorporation of Certain
  Documents by Reference....   2
Risk Factors................   4
Selling Shareholders........  13
Plan of Distribution........  14
Legal Matters...............  15
Experts.....................  15


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