EMISPHERE TECHNOLOGIES INC
S-3MEF, 1999-10-14
PHARMACEUTICAL PREPARATIONS
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<PAGE>

   As filed with the Securities and Exchange Commission on October   15, 1999.
                                                          Registration No. 333-
================================================================================


                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                                    FORM S-3
                             REGISTRATION STATEMENT
                        UNDER THE SECURITIES ACT OF 1933


                          EMISPHERE TECHNOLOGIES, INC.
             (Exact name of registrant as specified in its charter)



           DELAWARE                                       13-3306985
(State or other jurisdiction of                        (I.R.S. Employer
incorporation or organization)                       Identification Number)


                          765 Old Saw Mill River Road
                           Tarrytown, New York 10591
                                (914) 347-2220

         (Address, including zip code, and telephone number, including
            area code, of registrant's principal executive offices)

                             _____________________
                              Michael G. Goldberg
                         Emisphere Technologies, Inc.
                         765 Old Saw Mill River Road
                          Tarrytown, New York 10591
                                (914) 347-2220

(Name, address, including zip code, and telephone number, including area code,
of agent for service)

                             _____________________


                                  Copies to:

                            Edwin S. Maynard, Esq.
                   Paul, Weiss, Rifkind, Wharton & Garrison
                          1285 Avenue of the Americas
                           New York, New York  10019
                                (212) 373-3000

  Approximate date of commencement of proposed sale to the public:  As soon as
practicable after the effective date of this Registration Statement.
  If the only securities being registered on this Form are being offered
pursuant to dividend or interest reinvestment plans, please check the following
box. [ ]

  If any of the securities being registered on this Form are to be offered on a
delayed or continuous basis pursuant to Rule 415 under the Securities Act of
1933, other than securities offered only in connection with dividend or interest
reinvestment plans, check the following box. [_]

  If this Form is filed to register additional securities for an offering
pursuant to Rule 462(b) under the Securities Act, please check the following box
and list the Securities Act registration statement number of the earlier
effective registration statement for the same offering. [X]  No. 333-23423.

  If this Form is a post-effective amendment filed pursuant to Rule 462(c) under
the Securities Act, check the following box and list the Securities Act
registration statement number of the earlier effective registration statement
for the same offering. [ ]

  If delivery of the prospectus is expected to be made pursuant to Rule 434,
please check the following box. [ ]

                             _____________________

                        CALCULATION OF REGISTRATION FEE
<TABLE>
<CAPTION>
==============================================================================================================

      Title of Each Class            Amount to be     Proposed Maximum     Proposed Maximum      Amount of
 of Securities to be Registered(1)  Registered (2)     Offering Price Per     Aggregate       Registration Fee
                                                       Share (3)        Offering Price (2)

 <S>                                 <C>                      <C>                 <C>                <C>
 Common Stock, ($.01 par value)      575,000 shares           $ 15.56             $ 8,947,000        $ 2,488
==============================================================================================================
</TABLE>

(1)  This Registration Statement also applies to rights under the registrant's
     Rights Agreement which are attached to and tradable only with the shares of
     Common Stock registered hereby. No registration fee is required for such
     rights as they will be issued for no additional consideration.

(2)  Includes 300,000 shares subject to an over-allotment option.

(3)  Estimated solely for the purpose of calculating the registration fee in
     accordance with Rule 457(c) under the Securities Act of 1933, as amended,
     based upon the average of the high and low prices reported on the Nasdaq
     National Market on October 11, 1999.
================================================================================
<PAGE>

                           INCORPORATION BY REFERENCE
            OF REGISTRATION STATEMENT ON FORM S-3 FILE NO. 333-23423

          Emisphere Technologies, Inc. is incorporating by reference the
information contained in its Registration Statement on Form S-3 File No. 333-
23423, in its entirety including any and all amendments, as well as any exhibits
relating to it. The Registration Statement was declared effective by the
Securities and Exchange Commission May 28, 1997.


                                       2
<PAGE>

                                    PART II

                     INFORMATION NOT REQUIRED IN PROSPECTUS

Item 16.       Exhibits and Financial Statement Schedules

  (a)  Exhibits

Exhibit                             Description
Number                              -----------
- ---------

 5.1  *    Legal Opinion of Paul, Weiss, Rifkind, Wharton & Garrison.

23.1  *    Consent of PricewaterhouseCoopers LLP.

23.2  *    Consent of PricewaterhouseCoopers LLP.

23.3  *    Consent of Paul, Weiss, Rifkind, Wharton & Garrison (included in
           opinion filed as Exhibit 5.1).

24.1       Power of Attorney (filed with the Company's Registration Statement on
           Form S-3 (Registration No. 333-23423)).

*  Filed herwith.


  (b) Financial Statement Schedules

  None.

                                      II-1
<PAGE>

                                   SIGNATURES

     In accordance with the requirements of the Securities Act of 1933,
Emisphere Technologies, Inc. has authorized this Registration Statement to be
signed on its behalf by the persons described below, as directors and officers
of our company, in the City of New York, State of New York, on the 14th day of
October, 1999.

                                    EMISPHERE TECHNOLOGIES, INC.


                                    By:   /s/ Michael M. Goldberg
                                       ---------------------------
                                         Michael M. Goldeberg, M.D.
                                         Chairman of the Board and
                                         Chief Executive Officer



     In accordance with the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities indicated below on October 14, 1999.



             Signature                              Title
             ---------                              -----


/s/ Michael M. Goldberg              Director, Chairman of the Board and Chief
- -----------------------------------  Executive Officer
        Michael M. Goldberg

                      *              Director
- -----------------------------------
        Jere E. Goyan, Ph.D.

                      *              Director
- -----------------------------------
        Peter Barton Hutt


                      *
- -----------------------------------
        Howard M. Pack

                      *              Director
- -----------------------------------
        Mark I. Greene, M.D., Ph.D.


                      *              Director
- -----------------------------------
        Joseph R. Robinson, Ph.D.


                                     Director
- -----------------------------------
        Robert J. Levenson


/s/ Charles H. Abdalian, Jr.         Vice President, Chief Financial
- -----------------------------------  Officer and Secretary
        Charles H. Abdalian, Jr.

                                      II-2
<PAGE>

                     *
- -----------------------------------  Controller and Chief Accounting Office
        Joseph D. Poveromo





          /s/ Michael M. Goldberg
*  By:___________________________________________________
              Micheal M. Goldberg
              Attorney-in-fact

                                      II-3
<PAGE>

                                 EXHIBIT INDEX



Exhibit                            Description
- -------                            -----------

5.1     *  Legal Opinion of Paul, Weiss, Rifkind, Wharton & Garrison.

23.1    *  Consent of PricewaterhouseCoopers LLP.

23.2    *  Consent of PricewaterhouseCoopers LLP.

23.3    *  Consent of Paul, Weiss, Rifkind, Wharton & Garrison (included in
           opinion filed as Exhibit 5.1).

24.1       Power of Attorney (filed with the Company's Registration Statement on
           Form S-3 (Registration No. 333-23423)).

*  Filed herewith.

                                      II-4

<PAGE>

                                                                     EXHIBIT 5.1

                   PAUL, WEISS, RIFKIND, WHARTON & GARRISON
                          1285 Avenue of the Americas
                         New York, New York 10019-6064


                                                October 13, 1999


Emisphere Technologies, Inc.
765 Old Saw Mill River Road
Tarrytown, New York 10591


                         Emisphere Technologies, Inc.
                      Registration Statement on Form S-3

                                   ---------

Ladies and Gentlemen:

        In connection with the referenced Registration Statement on Form S-3
(the "Registration Statement") filed with the Securities and Exchange Commission
under the Securities Act of 1933, as amended (the "Act"), and the rules and
regulations under the Act ("the Rules"), Emisphere Technologies, Inc., a
Delaware corporation (the "Company"), has asked us to furnish our opinion as to
the legality of the 575,000 shares (the "Company Shares") offered by the Company
of the Company's common stock, par value $0.01 per share (the "Common Stock"),
which shares are registered for sale under the Registration Statement. In
connection with furnishing this opinion, we have reviewed the Registration
Statement (including all amendments), the form of the Underwriting
<PAGE>

Agreement relating to the sale of the Common Stock (the "Underwriting
Agreement"), originals, or copies certified or otherwise identified to our
satisfaction, of the Company's Certificate of Incorporation and By-laws, each as
in effect today and records of certain of the Company's corporated proceedings.
        We also have examined and relied upon representations as to factual
matters contained in certificates of officers of the Company, and have made
those other investigations of fact and law and have examined and relied upon the
originals, or copies certified or otherwise identified to our satisfaction, of
those documents, records, certificates or other instruments, and upon factual
information otherwise supplied to us, as in our judgment are necessary or
appropriate to render the opinions expressed below.
        In addition, we have assumed, without independent investigation, the
genuineness of all signatures, the authenticity of all documents submitted to us
as originals, the conformity of original documents to all documents submitted to
us as certified, photostatic, reproduced or conformed copies, the authenticity
of all the latter documents reviewed by us and the legal capacity of all
individuals who have executed any of the documents reviewed by us.
         Based upon the above, and subject to the stated assumptions, exceptions
and qualifications, we are of the opinion that the Company Shares are duly
authorized and, when issued, delivered and paid for as contemplated in the
Registration Statement and the Underwriting Agreement, will be validly issued,
fully paid and nonassessable.
<PAGE>

Our opinions expressed above are limited to the General Corporation Law of the
State of Delaware. Our opinion is rendered only with respect to laws and the
rules, regulations and orders under them, which are currently in effect.

We consent to the use of this opinion as an Exhibit to the Registration
Statement and to the use of our name under the heading "Legal Matters" contained
in the prospectus and incorporated into the Registration Statement. In giving
these consents, we do not admit that we come within the category of persons
whose consent is required by the Act or the Rules.


                               Very truly yours,

                      /s/ PAUL, WEISS, RIFKIND, WHARTON & GARRISON

<PAGE>

                                                                    Exhibit 23.1


                      CONSENT OF INDEPENDENT ACCOUNTANTS

        We consent to the incorporation by reference in this registration
statement on Form S-3 of our report dated September 30, 1999, relating to our
audits of the financial statements of Emisphere Technologies, Inc. (the
"Company") as of July 31, 1999 and 1998, and for each of the three years in the
period ended July 31, 1999, which report is included in the Company's Annual
Report on Form 10-K for the year ended July 31, 1999.


                                        /s/ PricewaterhouseCoopers LLP

New York, New York
October 12, 1999

<PAGE>


                                                                    Exhibit 23.2


                      CONSENT OF INDEPENDENT ACCOUNTANTS

        We consent to the incorporation by reference in this registration
statement on Form S-3 of our report dated September 10, 1999, relating to our
audits of the financial statements of Ebbisham Limited as of July 31, 1998, and
for each of the periods from September 26, 1996 (inception) to July 31, 1997,
the year ended July 31, 1998, the period from August 1, 1998 to July 2, 1999 and
for the cumulative period from September 26, 1996 (inception) to July 2, 1999,
which report is included in the Emisphere Technologies, Inc.'s Annual Report on
Form 10-K for the year ended July 31, 1999.


                                        /s/ PricewaterhouseCoopers LLP

New York, New York
October 12, 1999


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