ONCOR INC
10-Q, 1997-05-15
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                       SECURITIES AND EXCHANGE COMMISSION
                            WASHINGTON, D.C.  20549
                                
                                    FORM 10-Q
                                
                 QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d)
                     OF THE SECURITIES EXCHANGE ACT OF 1934
                                
                      For the quarter ended March 31, 1997
                                
                         Commission file number 0-16177
                                
                                
                                  ONCOR, Inc.                         
                                
              (Exact name of registrant as specified in its charter)
                                
                 Maryland                       52-1310084          
         (State of Incorporation)    (I.R.S Employer Identification No.)
                                
                              209 Perry Parkway
                        Gaithersburg, Maryland  20877     
                   (Address of principal executive offices)
                                  (Zip code)
                                
                               (301) 963-3500                          
             (Registrant's telephone number, including area code)


Indicate by check mark whether the registrant (1) has filed all reports
required to be filed by Section 13 or 15(d) of the Securities Exchange Act of
1934 during the preceding 12 months (or for such shorter period that the
registrant was required to file such reports), and (2) has been subject to
such filing requirements for the past 90 days.



                      YES  x                        NO     


At April 30, 1997, there were 25,112,338 shares of Common Stock outstanding. <PAGE>

                       PART I - FINANCIAL INFORMATION

Item 1.   Financial Statements.

     The unaudited consolidated balance sheet as of March 31, 1997, the
audited consolidated balance sheet as of December 31, 1996, and the unaudited
consolidated statements of operations and of cash flows for the three month
periods ended March 31, 1997 and 1996, set forth below, have been prepared
pursuant to the rules and regulations of the Securities and Exchange
Commission (the "Commission").  Certain information and note disclosures
normally included in the annual financial statements prepared in accordance
with generally accepted accounting principles have been condensed or omitted
pursuant to those rules and regulations.  Oncor, Inc. (the "Company") believes
that the disclosures made are adequate to make the information presented not
misleading.

     In the opinion of management of the Company, the accompanying
consolidated financial statements reflect all adjustments (consisting only of
normal recurring adjustments) that are necessary for a fair presentation of
results for the periods presented.  It is suggested that this financial
information be read in conjunction with the Form 10-K, including "Item 1.
Business - Additional Risk Factors," filed with the Commission for the year
ended December 31, 1996.

     The results for the first three month period ended March 31, 1997, 
presented in the accompanying financial statements, are not necessarily
indicative of the results for the entire year.  In addition, the results for
the three month period ended March 31, 1996 have been restated to give effect
to the accounting treatment for the Company's convertible debentures.  See
Note 6 of the Notes to Financial Statements.<PAGE>

<TABLE>
                                ONCOR, INC.

                        CONSOLIDATED BALANCE SHEETS
                           
<CAPTION>          
                                                        As of      
                                            ------------------------------
                                             Mar. 31, 1997  Dec. 31, 1996
                                               Unaudited
                                            ------------------------------
<S>                                  ASSETS
CURRENT ASSETS:                            <C>             <C>
  Cash and cash equivalents                   $12,941,192    $13,058,657   
  Short-term investments, at market             2,808,149        388,504
  Restricted cash                                 700,000      5,432,478
  Accounts receivable, net of allowance
    for doubtful accounts of approxi-     
    mately $417,000 and $372,000                2,050,436      2,401,639
  Receivable from Officer/Director                302,542        294,039
  Inventories                                   4,034,635      3,839,630
  Other current assets                          1,303,718        863,060
                                              ------------   ------------
    Total current assets                       24,140,672     26,278,007
                                              ------------   ------------  

NON-CURRENT ASSETS:
  Property and equipment, net                   4,735,539      5,044,270
  Deposits and other non-current assets           441,108        216,035
  Investment in and advances to affiliates      2,839,484      3,213,548
  Intangible assets, net                        6,083,136      6,918,278
                                              ------------   ------------
    Total non-current assets                   14,099,267     15,392,131
                                              ------------   ------------

     Total assets                             $38,239,939    $41,670,138
                                              ============   ============

                   LIABILITIES AND STOCKHOLDERS' EQUITY
CURRENT LIABILITIES:                    
  Accounts payable                             $2,785,658      $2,523,585
  Accrued expenses and other current
    liabilities                                   980,676       1,656,900
  Current portion of long-term debt               764,518         719,337
                                              ------------   -------------
    Total current liabilities                   4,530,852       4,899,822
                                              ------------   -------------

LONG-TERM DEBT                                 11,456,297      10,386,110
                                              ------------   -------------

    Total liabilities                          15,987,149      15,285,932     
                                              ------------   -------------<PAGE>
COMMITMENTS AND CONTINGENCIES         

MINORITY INTEREST IN CONSOLIDATED           
  SUBSIDIARY                                    2,935,617         3,040,119
                                              ------------     -------------

STOCKHOLDERS' EQUITY:
  Preferred stock, $.01 par value, 1,000,000
    shares authorized, no shares issued             -               -
  Common stock, $.01 par value,
    50,000,000 shares authorized,
    25,112,338 and 24,214,349 issued;
    25,032,929 and 24,134,940 outstanding         251,123         242,143
  Common stock warrants outstanding               781,250         781,250
  Additional paid-in capital                  130,251,411     125,327,438  
  Deferred compensation                          (573,214)       (641,270)
  Unrealized gain on investments                   (2,204)            (94)
  Cumulative translation adjustment            (1,530,205)       (508,172)
  Accumulated deficit                        (109,640,476)   (101,636,696)
  Less - 79,409 shares of common
    stock held in treasury, at cost              (220,512)       (220,512)
                                              ------------   -------------
    Total stockholders' equity                 19,317,173      23,344,087
                                              ------------   -------------

     Total liabilities and
     stockholders' equity                     $38,239,939     $41,670,138
                                              ============   =============


                The accompanying notes are an integral part
                of these consolidated financial statements.

</TABLE>
<PAGE>
<TABLE>

                                   ONCOR, INC.
                      CONSOLIDATED STATEMENTS OF OPERATIONS
                                   (Unaudited)
<CAPTION>
                                   For the Three Months Ended    
                                            March 31,
                                 ------------------------------
                                      1997             1996   
                                 ------------------------------
<S>
GROSS REVENUES:                 <C>               <C>
  Product sales                   $3,204,386       $3,923,372     
  Grants and contracts               122,750          272,025 
                                 ------------     ------------

  Gross revenues                   3,327,136        4,195,397  

OPERATING EXPENSES:
  Direct cost of sales             1,930,049        2,413,115 
  Amortization of 
   intangibles                       307,119          344,379 
  Selling, general and    
   administrative                  3,241,100        3,458,816
  Research and development         1,540,530        1,986,477  
  Clinical and regulatory            456,166          492,279 
                                 ------------     ------------

  Total operating expenses         7,474,964        8,695,066

LOSS FROM OPERATIONS              (4,147,828)      (4,499,669) 

OTHER INCOME (EXPENSE):
  Investment income                  193,845          178,964  
  Interest and other expenses,
   net (Note 6)                   (2,745,923)        (660,695) 
  Foreign exchange loss               (4,787)         (21,165)
  Equity in net loss of
   affiliates                     (1,299,087)      (1,596,772)
                                 ------------     ------------
                                  (3,855,952)      (2,099,668)

 
   Net loss                      ($8,003,780)     ($6,599,337)
                                 ============     ============
                                                              

NET LOSS PER SHARE                    ($0.32)          ($0.30) 
                                 ============     ============

WEIGHTED-AVERAGE COMMON
  SHARES OUTSTANDING              24,865,816       21,815,426  
                                 ============     ============

              The accompanying notes are an integral part of these 
                       consolidated financial statements.
</TABLE>
<PAGE>
<TABLE>
                              ONCOR, INC.

                   CONSOLIDATED STATEMENTS OF CASH FLOWS
                                (Unaudited)                               
<CAPTION>
                                          For the three months ended March 31,
                                          ------------------------------------
                                                    1997              1996     
                                          ------------------------------------
<S>  
CASH FLOWS FROM OPERATING ACTIVITIES:         <C>               <C>
  Net loss                                      ($8,003,780)      ($6,599,337)
  Adjustments to reconcile net loss to
   net cash used in operating activities:
      Issuance of common stock for interest
       and imputed interest of convertible
       notes                                      2,175,000           569,842
      Issuance of common stock in 
       connection with research and 
       development agreements                       111,681           192,505
      Depreciation and amortization                 649,547           745,740
      Expenses for non-employee stock options       107,118             -
      Equity in net loss of affiliate 
       and other                                  1,319,670         1,596,775 
      Changes in operating assets
       and liabilities:                      
        Accounts receivable                         235,403           803,411  

        Inventories                                (295,661)          268,213 
        Other current assets                         29,129           (64,325)
        Deposits and other non-current assets       (24,743)           12,787 
        Accounts payable                           (153,407)         (379,526)
        Accrued expenses and other
         liabilities                                384,941          (536,125)
        Deferred rent                                 -               (18,223)
          Net cash used in operating
           activities                            (3,465,102)       (3,408,263)
                                                -------------    -------------
               
                                
CASH FLOWS FROM INVESTING ACTIVITIES:
  Purchases of property and equipment              (114,303)         (152,779)
  Purchases of investments                       (2,421,755)       (2,590,110)
                                                -------------    -------------
             
          Net cash used in investing           
           activities                            (2,536,058)       (2,742,889)
                                                -------------    -------------
                                             
CASH FLOWS FROM FINANCING ACTIVITIES:   
  Offering costs of private placement                 -               (54,100)
  Exercise of stock options and warrants             19,950           199,950
  Reduction in restricted funds                   4,732,478             -  
  Payment on notes for acquisitions                   -              (603,444)
 
  Payment on bank loans                             (96,201)         (328,601)
  Loan to unconsolidated affiliate                 (250,000)            -    



  Proceeds from borrowings and issuance
    of warrants                                   2,000,000           207,410
                                                -------------    -------------
              
         Net cash provided by (used in)
          financing activities                    6,406,227          (578,785)
                                                -------------    -------------
 

                                                -------------    -------------
EFFECT OF CHANGE IN EXCHANGE RATE ON CASH          (522,532)          (14,669)
                                                -------------    -------------
                     
  Net decrease in cash and cash
   equivalents                                     (117,465)       (6,744,606)

CASH AND CASH EQUIVALENTS, beginning of 
  the period                                     13,058,657        13,458,895
                                                -------------    -------------
                                 
CASH AND CASH EQUIVALENTS, end of the
  period                                        $12,941,192        $6,714,289
                                                                              

            The accompanying notes are an integral part of these
                    consolidated financial statements.

</TABLE>
<PAGE>
                          ONCOR, INC.

                  NOTES TO FINANCIAL STATEMENTS

                       AS OF MARCH 31, 1997
                           (Unaudited)


1.   Cash Equivalents and Investments

     Cash equivalents and investments consist primarily of funds invested in
money market instruments, commercial paper and U.S. government treasury bills. 
Investments with maturities between three months and one year are classified
as short-term investments.  Investments in securities with original maturities
of three months or less are considered cash equivalents.  Approximately $0.7
million in restricted cash is pledged as collateral for a loan of an officer
and director for an indefinite period of time.
     
      Investments that are classified as available-for-sale securities are
carried at fair market value.  Unrealized holding gains and losses are
excluded from earnings and reported as a net amount in a separate component of
shareholders' equity until realized. 


2.   Intangible Assets

     The intangible assets comprise technology acquired, the estimated value
of contractual positions, and the excess of the purchase price of an
acquisition over the fair market value of the tangible assets acquired.  The
intangible assets are being amortized on a straight line method over periods
of five to ten years, with a weighted average amortization period of eight
years.


3.   Net Loss Per Share

     Net loss per share is determined using the weighted-average number of
shares of Common Stock outstanding during the periods presented.  The effects
of options and warrants have not been considered since the effects would be
antidilutive.

     The Financial Accounting Standards Board has issued Statement No. 128,
Earnings Per Share.  Statement 128 requires dual presentation of basic and
diluted earnings per share on the face of the income statement for all periods
presented.  Statement 128 is effective for fiscal years ending after December
15, 1997 and requires restatement of prior years' earnings per share.  Since
the effect of outstanding options is antidilutive, they have been excluded
from the Company's computation of net loss per share.  Accordingly, Statement
128 does not have an impact upon historical net loss per share as reported.


4.   Investments in Debt Securities at March 31, 1997

     The aggregate fair value of investments in debt securities as of 
March 31, 1997 is as follows:<PAGE>
          Government securities
              $U.S. denominated                   $1,131,077
          Commercial paper                         1,892,824
                                                  ----------
                          Total                   $3,023,901


5.   Oncor Private Placement

     In January 1997, the Company completed a private placement of 6.0%
five-year unsecured
notes convertible into shares of Common Stock of the Company.  The Company
received total proceeds of approximately $2.0 million.  Issuance costs were
not significant.  The notes are immediately convertible at the option of the
holder and will be automatically converted upon maturity.  The notes are
convertible at prices which reduce from 100.0% to 80.0% of the market value of
the Common Stock at the time of conversion over a period of 120 days.


6.   Accounting for the Issuance of Convertible Debentures

     In December 1995, August 1996, December 1996 and January 1997, the
Company issued convertible debentures in private placements in exchange for
cash of $7.0 million, $5.0 million, $8.0 million and $2.0 million,
respectively.  In each such issuance, the holders of the debentures had
"beneficial conversion" rights to convert the debentures into common shares of
the Company at established discounts to the quoted trading price of the shares
in a period immediately preceding the dates of conversions.

     The value of the fixed discount, ranging from 15%-20% of the respective
issuance's face value of the Company's issuances, has been reflected in the
interest expense in an aggregate amount of $2.2 million and $0.5 million in
1997 and 1996, respectively.  Such additional fixed discount has been accreted
for the period from date of issuance through the conversion dates of the
respective issuances.

     The unaudited financial position and results of operations for the
unaudited quarter ending March 31, 1996 has been restated to give effect to
the accounting treatment announced in March 1997 by the staff of the
Securities and Exchange Commission (SEC) at a meeting of the Emerging Issues
Task Force relevant to certain of the Company's convertible debentures having
"beneficial conversion" features.

     The first quarter of 1996 has been restated as follows:

                                    Originally         
                                     Reported      As Restated
                                   ------------   -------------
          Interest and other
            expense, net           $  (151,695)   $   (660,695)

          Net loss                  (6,090,337)     (6,599,337)

          Net loss per share           (0.28)          (0.30)


7.   Related Party Transactions

     During the first quarter of 1997, the Company agreed to increase the
guarantee of a loan for an officer and director from $700,000 to $960,000.<PAGE>
Item 2.   Management's Discussion and Analysis of Financial Condition and
          Results of Operations.

     The following discussion and analysis provides information which
management believes is relevant to an assessment and understanding of the
Company's results of operations and financial condition.  The discussion
should be read in conjunction with the audited consolidated financial
statements of the Company and notes thereto, which were included in the
Company's Annual Report on Form 10-K for fiscal year ended December 31, 1996. 
This Form 10-Q contains certain statements of a forward-looking nature
relating to future events or the future financial performance of the Company. 
Readers are cautioned that such statements are only predictions and that
actual events or results may differ materially.  In evaluating such
statements, readers should specifically consider the various factors
identified in this Report which could cause actual results to differ
materially from those indicated by such forward-looking statements, including
the matters set forth in "Risk Factors."

Results of Operations
     
     Consolidated products sales decreased 18% to $3.2 million in the three
months ended March 31, 1997 compared to $3.9 million in the three months ended
March 31, 1996.  The sales decrease was attributable to the discontinuation of
certain product lines and to the 11% change in exchange rates between the
dollar and French franc.  After adjusting for the elimination of the sales of
discontinued products, sales of continuing products increased 5%.

     Contract and grant revenue decreased 55% to $0.1 million in the three
months ended March 31, 1997 compared to $0.3 million in the three months ended
March 31, 1996, due to the completion of certain research grants.  Application
for renewal of the research grants has been made, but there can be no
assurance that such renewals will be granted.

     Gross profit as a percentage of product sales increased to 39.8% in the
three months ended March 31, 1997 from 38.5% in the three months ended March
31, 1996.  The increase, which was due to the discontinuation of sales of
lower profit product lines, was partially offset by the costs for regulating
the initial stages of the manufacture of a controlled diagnostic product.

     Amortization of intangible assets in the three months ended March 31,
1997 and the three months ended March 31, 1996 was due to the amortization of
the portion of the purchase price of Appligene S.A. attributable to the value
of intangible assets acquired, primarily for contracts, completed research
projects, and the excess of the purchase price over the book value of the
assets acquired.  The intangible assets are being amortized on a straight line
basis over periods ranging from two to ten years, with a weighted average
period of approximately eight years.

     Selling, general and administrative expenses decreased 6% to $3.2
million in the three months ended March 31, 1997 from $3.5 million in the
three months ended March 31, 1996.  The beneficial effects of the
discontinuation plan instituted in the second quarter of 1996, change in
exchange rates and the postponement of certain marketing programs accounted
for a decrease of $0.5 million, which decrease was partially offset by (i)
legal and other expenses associated with certain intellectual property issues
and (ii) the continuing development of a sales and marketing staff in Europe. 
An anticipated reduction in the aforementioned legal expenses and the
implementation of the aforementioned marketing programs are expected to have
largely offsetting effects on selling, general and administrative expenses
throughout 1997.

     Research and development expenses decreased 22% to $1.5 million in the
three months ended March 31, 1997 from $2.0 million in the three months ended
March 31, 1996.  This decrease is a result of initial payments made to The
John Hopkins University under collaboration research agreements in the three
months ended March 31, 1996, which payments were not repeated in the three
months ended March 31, 1997, and to the effect of the above mentioned product
discontinuation plan.

     Clinical and regulatory expense remained largely unchanged for the three
months ended March 31, 1997 compared to the three months ended March 31, 1996. 
This expense is expected to continue at approximately this rate throughout
1997.

     Other net non-operating expenses increased by $1.8 million in the three
months ended March 31, 1997 compared to the three months ended March 31, 1996. 
This increase resulted primarily from increased interest expense which has
become substantially more significant through the issuance of convertible
debentures in 1995, 1996 and 1997.  In the three months ended March 31, 1997,
interest and other expenses included a non-cash charge of $2.2 million
compared to $0.5 million in the three months ended March 31, 1996.  This
charge represents the value of the beneficial conversion feature in the
conversion formula associated with certain issuances of the convertible
debenture by the Company.  Such charges will continue at a lower rate through
the second quarter of 1997.  The net increase in interest and other expenses
was partially offset by a decrease of $0.3 million in the equity in net losses
of affiliates.  The Company's proportionate share of net losses attributable
to Codon decreased due to a significant decrease in the Company's ownership
percentage.  

     As a result of the factors discussed above, net loss increased to $8.0
million ($0.32 per share) in 1997 from $6.6 million ($0.30 per share) in 1996.

Liquidity and Capital Resources

     The following table sets forth the most significant elements of the cash
flows of the Company in the first quarter of 1997 (in millions):

     Cash and liquid investments at January 1, 1997              $18.9
     
     Net cash loss from operations                                (3.6)

     Proceeds from issuance of debentures                          2.0
 
     Effects of foreign exchange rate adjustments,
     purchases of equipment and other                             (0.8)

     Cash and liquid investments at March 31, 1997               $16.5


     The net cash used in operating activities is the result of the losses of
the Company described in "Results of Operations" above.  Approximately $6.3
million of the cash and liquid investments shown in the table set forth above
is limited to fund operations of the Company's European subsidiary.

     Purchases of equipment resulted from the on-going replacement of office
and laboratory equipment; the Company expects such purchases to continue at
this rate.  Any substantial leasehold improvements which may be required in
manufacturing facilities are expected to be funded by the Company's primary
landlord in accordance with the Company's current lease agreements. 

     The Company has available for use in operations in North America, where
most of its cash losses occur, (i) approximately $10.2 million dollars at
March 1997 and (ii) an irrevocable commitment from a lending source in the
amount of $3.0 million expiring March 31, 1998.  The Company also holds
marketable securities in affiliated companies with a present market value of
approximately $21.6 million dollars, though substantial contractual,
regulatory and market restrictions exist with respect to the rate at which
these investments could be liquidated and significantly fluctuating market
prices make the ultimate future selling prices unpredictable.  With respect to
North America, the Company believes that it has sufficient sources of cash to
fund operations through the remainder of 1997 but believes that it will need
to raise funds or liquidate assets shortly thereafter.  The Company plans to
raise needed additional financing through private equity placements and
collaborative or other arrangements with corporate partners and others.  There
can be no assurance that the Company will be able to obtain additional
financing when needed, if at all, or on terms acceptable to the Company.  The
Company currently has no commitments to receive additional financing.  Any
additional funding which it may raise in 1997 or 1998 likely will be dilutive
to the interests of the current shareholders.  Since December 1995, the
principal source of funds for North American operations has been through the
issuance of convertible debt securities.  There are terms in certain of the
agreements underlying these transactions which would make it more difficult to
consummate similar such transactions in the future.  There can be no assurance
that the Company could access such funding or other funding sources in the
future on commercially reasonable terms, if at all.   

     With respect to Europe, the Company believes that its cash position of
approximately $6.3 million is sufficient to fund operations beyond 1997.

Risk Factors

     Risk Associated with the HER-2/neu Gene-Based Test System

     In November 1995, an FDA advisory panel (the "Panel") made a
recommendation against final approval of the Company's Pre-Market Approval
("PMA") application for the use of its HER-2/neu gene-based test system for
diagnostic purposes.  No assurance can be given that the Panel will reconsider
its position or that the FDA will overturn the recommendation of the Panel or
that the Company will obtain FDA approval for its HER-2/neu gene-based test
system.  The failure to obtain FDA approval for its HER-2/neu gene-based test
system on a timely basis, or at all, would have a material and adverse effect
on the Company's business, financial condition and results of operations.  In
the event that the Company receives FDA approval for its HER-2/neu gene-based
test system, there can be no assurance that the Company will be capable of
manufacturing the test system in commercial quantities at reasonable costs or
marketing the product successfully, that the test system will be accepted by
the medical community, or that the market demand for the test system will be
sufficient to allow profitable sales.

     No Assurance of Regulatory Approvals; Government Regulation

     The Company is currently pursuing FDA approval of certain existing
products and expects to pursue FDA approval of certain additional products
under development.  There can be no assurance that the Company will receive
regulatory approval for any of its products or, even if it does receive
regulatory approval for a particular product, that the Company will ever
recover its costs in connection with obtaining such approval.  The timing of
regulatory approvals is not within the control of the Company.  The failure of
the Company to receive requisite approval, or significant delays in obtaining
such approval, could have a material and adverse effect on the business,
financial condition and results of operations of the Company.  Approval by the
FDA requires lengthy, detailed and costly laboratory procedures, clinical
testing procedures and application preparation and defense efforts to
demonstrate a product's efficacy and safety before a product can be sold for
diagnostic use.  Even if such regulatory approval is obtained for a product,
its manufacturer and its manufacturing facilities are subject to continual
review and periodic inspections by the FDA and other regulatory agencies.  The
regulatory standards for manufacturing are applied stringently by the FDA. 
Discovery of previously unknown problems with a product, manufacturer or
facility may result in restrictions on such product or manufacturer, including
costly recalls or even withdrawal of the product from the market. 
Furthermore, approval may entail ongoing requirements for postmarketing
studies.  Failure to maintain requisite manufacturing standards or discovery
of previously unknown problems could have a material and adverse effect on the
Company's business, financial condition or results of operations.

     Patents and Proprietary Rights

     The Company's success will depend in large part on its, or its
licensors', ability to obtain patents, defend its patents, maintain trade
secrets and operate without infringing upon the proprietary rights of others,
both in the United States and in foreign countries.  The patent position of
firms relying upon biotechnology is highly uncertain in general and involves
complex legal and factual questions.  To date there has emerged no consistent
policy regarding the breadth of claims allowed in biotechnology patents or the
degree of protection afforded under such patents.  The Company relies on
certain patents and pending United States and foreign patent applications
relating to various aspects of its products.  These patents and patent
applications are either owned by the Company or rights under them are licensed
to the Company.  There can be no assurance that patents will issue as a result
of any such pending applications or that, if issued, such patents will be
sufficiently broad to afford protection against competitors with similar
technology.  In addition, there can be no assurance that any patents issued to
the Company, or for which the Company has license rights, will not be
challenged, invalidated or circumvented, or that the rights granted thereunder
will provide competitive advantages to the Company.  The commercial success of
the Company will also depend upon avoiding the infringement of patents issued
to competitors and upon maintaining the technology licenses upon which certain
of the Company's current products are, or any future products under
development might be, based.  Litigation, which could result in substantial
cost to the Company, may be necessary to enforce the Company's patent and
license rights or to determine the scope and validity of others' proprietary
rights.  If competitors of the Company prepare and file patent applications in
the United States that claim technology also claimed by the Company, the
Company may have to participate in interference proceedings declared by the
United States Patent and Trademark Office ("PTO") to determine the priority of
invention, which could result in substantial cost to the Company, even if the
outcome is favorable to the Company.  An adverse outcome could subject the
Company to significant liabilities to third parties and require the Company to
license disputed rights from third parties or cease using the technology.  A
United States patent application is maintained under conditions of
confidentiality while the application is pending in the PTO, so that the
Company cannot determine the inventions being claimed in pending patent
applications filed by its competitors in the PTO. Further, United States
<PAGE>
patents do not provide any remedies for infringement that occurred before the
patent is granted. 

     The University of California and its licensee, Vysis, Inc. ("Vysis"),
filed suit against Oncor on September 5, 1995 for infringement of U.S. Patent
No. 5,447,841 entitled Methods and Compositions for Chromosome Specific
Staining which issued on that same date.  The patent relates to a method of
performing in situ hybridization using a blocking nucleic acid that is
complementary to repetitive sequences.  The Company has requested summary
judgment of invalidity, non-infringement and unenforceability of the patent
claims in suit.  The University and Vysis have requested a summary judgment of
infringement and validity.  In January 1997, a summary judgment hearing was
held but as of May 7, 1997, there had been no decision on the motions.  A
failure to successfully defend against or settle this suit may result in
damages being assessed against the Company and an injunction against the sale
of some of the Company's probes and genetic test kits. 

     The Company has licensed rights to inventions disclosed in United States
and foreign patent applications relating to methods and probes for detecting
the presence of the Fragile X syndrome. The Company believes that its
licensors are original inventors and are entitled to patent protection in the
United States, but the Company is aware that certain third parties also have
filed patent applications in the United States and abroad and claim to be
entitled to patents related to this technology.  The Company has initiated an
interference proceeding with these third parties in the PTO to resolve which
party is entitled to a United States patent, if any.  The application licensed
by the Company is senior in the interference.  The Company has settled the
interference with respect to one of the parties, and has reached a settlement
agreement in principle with the other party.  An unfavorable decision in such
a proceeding could have an adverse effect on the Company.

     The Company currently has certain licenses from third parties and in the
future may require additional licenses from other parties to develop,
manufacture and market commercially viable products effectively.  There can be
no assurance that such licenses will be obtainable on commercially reasonable
terms, if at all, that the patents underlying such licenses will be valid and
enforceable or that the proprietary nature of the patented technology
underlying such licenses will remain proprietary.

     The Company relies substantially on certain technologies that are not
patentable or proprietary and are therefore available to the Company's
competitors.  The Company also relies on certain proprietary trade secrets and
know-how that are not patentable.  Although the Company has taken steps to
protect its unpatented trade secrets and know-how, in part through the use of
confidentiality agreements with its employees, consultants and certain of its
contractors, there can be no assurance that these agreements will not be
breached, that the Company would have adequate remedies for any breach, or
that the Company's trade secrets will not otherwise become known or be
independently developed or discovered by competitors.

     Uncertainties Relating to Product Development

     Most of the Company's products have not been approved by the FDA and may
be sold only for research purposes.  The Company has undertaken to seek FDA
approval for certain of these products, and may in the future undertake to
seek such approval for other products, and substantial additional investment,
laboratory development, clinical testing and FDA approval will be required
prior to the commercialization of such products for diagnostic purposes. 
There can be no assurance that the Company will be successful in developing
such existing or future products, that such products will prove to be
efficacious in clinical trials, that required regulatory approvals can be
obtained for such products, that such products, if developed and approved,
will be capable of being manufactured in commercial quantities at reasonable
costs, will be marketed successfully or will be accepted by the medical
diagnostic community, or that market demand for such products will be
sufficient to allow profitable operations.

     International Sales and Foreign Exchange Risk

     The Company derived approximately $8.7 million or 57% of its total
product revenues, from customers outside of the United States for the year
ended December 31, 1996.  The Company anticipates that a significant amount of
its sales will take place in European countries and likely will be denominated
in currencies other than the U.S. dollar.  These sales may be adversely
affected by changing economic conditions in foreign countries and by
fluctuations in currency exchange rates.  Any significant decline in the
applicable rates of exchange could have a material adverse effect on the
Company's business, financial condition and results of operations.  Additional
risks inherent in the Company's international business activities generally
include unexpected changes in regulatory requirements, tariffs and other trade
barriers, lack of acceptance of products in foreign markets, longer accounts
receivable payment cycles, difficulties in managing international operations,
potentially adverse tax consequences, restrictions on repatriation of earnings
and the burdens of complying with a wide variety of foreign laws.  There can
be no assurance that such factors will not have a material adverse effect on
the Company's future international revenues and, consequently, on the
Company's business, financial condition and results of operations.

     Competition and Technological Change

     The diagnostic and biotechnology industries are subject to intense
competition and rapid and significant technological change.  Competitors of
the Company in the United States and in foreign countries are numerous and
include, among others, diagnostic, health care, pharmaceutical, biotechnology
and chemical companies, academic institutions, government agencies and other
public and private research organizations.  Many of these competitors have
substantially greater financial and technical resources and production and
marketing capabilities than the Company.  There can be no assurance that these
competitors will not succeed in developing technologies and products that are
more effective, easier to use or less expensive than those that have been or
are being developed by the Company or that would render the Company's
technology and products obsolete and noncompetitive.  The Company also
competes with various companies in acquiring technology from academic
institutions, government agencies and research organizations.  In addition,
many of the Company's competitors have significantly greater experience than
the Company in conducting clinical trials of new diagnostic products and in
obtaining FDA and other regulatory approvals of products for use in health
care.  Accordingly, the Company's competitors may succeed in obtaining
regulatory approval for products more rapidly than the Company.  

     Investment in OncorMed and Codon

     The Company owns approximately 26% of the common stock of its
publicly-traded affiliate, OncorMed, and 42% of the voting securities of its
affiliate, Codon.  The shares of common stock of both OncorMed and  Codon held
by the Company are not currently freely tradeable and no public market exists
for the Common Stock of  Codon.  Therefore, there can be no assurance that the
Company will be able to realize the economic benefit of its investment or
predict the timing of such realization.  The value of the Company's investment
in OncorMed represents a significant portion of the total assets of the
Company and such value fluctuates with the market price of OncorMed's common
stock.  Therefore, any event that has a material and adverse effect on the
market price of the common stock of OncorMed will have a material and adverse
effect on the value of the Company's investment in OncorMed.  Although Stephen
Turner, the Company's Chief Executive Officer, is a Director of OncorMed and
the Company is a significant stockholder in OncorMed, the Company does not
control the day-to-day operations and management of OncorMed and, therefore,
has little direct control over its operations and financial results.   Codon
will require additional financing in the future.  The Company does not
currently intend to provide a significant portion of such financing although
the Company may provide additional financing in the future.  The failure of 
Codon to obtain any required financing on acceptable terms could have a
material and adverse effect on the value of the Company's investment in Codon. 

     Other Factors

     Other factors that may affect the Company's business, financial
condition and results of operations, include the Company's limited
manufacturing, marketing and distribution experience, the level and
availability of government funding, the Company's ability to attract and
retain key personnel, potential health care reform measures and the
availability of third-party reimbursement, potential product liability claims,
and environmental risks.<PAGE>
Item 6.   Exhibits and Reports on Form 8-K.


a.   The following exhibits are filed as part of this report on Form 10-Q.

     27.  Financial Data Schedule.

     28.  Leases.

b.   Reports on Form 8-K.

     None.
                                 

<PAGE>
                            SIGNATURES



    Pursuant to the requirements of the Securities Exchange Act
of 1934, the registrant has duly caused this report to be signed
on its behalf by the undersigned thereunto duly authorized.
 

                              ONCOR, INC.                          
                             (Registrant)                      


Date:  May 13, 1997                                          
                           Stephen Turner, Chairman and Chief                  
              
                             Executive Officer     



Date:  May 13, 1997        Cecil Kost, President and Chief
                             Operating Officer
     


Date:  May 13, 1997        John L. Coker, Vice President
                             of Finance and Administration,
                             Chief Financial Officer

<PAGE>
                            SIGNATURES




    Pursuant to the requirements of the Securities Exchange Act
of 1934, the registrant has duly caused this report to be signed
on its behalf by the undersigned thereunto duly authorized.


                           ONCOR, INC.                          
                           (Registrant)                      


Date:  May 13, 1997        /s/  Stephen Turner               
                          Stephen Turner, Chairman and Chief              
                            Executive Officer      



Date:  May 13, 1997        /s/  Cecil Kost
                          Cecil Kost, President and Chief
                             Operating Officer
     


Date:  May 13, 1997        /s/  John L. Coker                
                          John L. Coker, Vice President
                             of Finance and Administration,
                             Chief Financial Officer

<TABLE> <S> <C>

<ARTICLE> 5
       
<S>                             <C>
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<FISCAL-YEAR-END>                          DEC-31-1997
<PERIOD-END>                               MAR-31-1997
<CASH>                                        12941195
<SECURITIES>                                         0
<RECEIVABLES>                                  2468145
<ALLOWANCES>                                  (417709)
<INVENTORY>                                    4034635
<CURRENT-ASSETS>                              24140672
<PP&E>                                        10818160
<DEPRECIATION>                               (6082621)
<TOTAL-ASSETS>                                38239939
<CURRENT-LIABILITIES>                          4530852
<BONDS>                                              0
                                0
                                          0
<COMMON>                                        251123
<OTHER-SE>                                    19066050
<TOTAL-LIABILITY-AND-EQUITY>                  38239939
<SALES>                                        3204386
<TOTAL-REVENUES>                               3327136
<CGS>                                          1930049
<TOTAL-COSTS>                                  7474964
<OTHER-EXPENSES>                             (3855952)
<LOSS-PROVISION>                                     0
<INTEREST-EXPENSE>                             2756187
<INCOME-PRETAX>                              (8003780)
<INCOME-TAX>                                         0
<INCOME-CONTINUING>                          (8003780)
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                                 (8003780)
<EPS-PRIMARY>                                   (0.32)
<EPS-DILUTED>                                   (0.32)
        

</TABLE>


                      FIRST AMENDMENT TO THE LEASE BETWEEN

                        SAUL HOLDINGS LIMITED PARTNERSHIP

                                 AND ONCOR, INC.
                                200 PERRY PARKWAY

         This FIRST AMENDMENT TO LEASE is made and entered into this 4th day of
November 1996 by and between SAUL HOLDINGS LIMITED PARTNERSHIP (hereinafter
referred to as "Landlord"), and ONCOR, INC. a Maryland Corporation (hereinafter
referred to as "Tenant").

         WHEREAS, Landlord and Oncor, Inc. have entered into that certain Lease
dated December 2, 1994 (the "Lease") for approximately 19,581 square feet in 200
Perry Parkway, Avenel Business Park, Gaithersburg, Maryland 20877; and

         WHEREAS, the parties hereto desire to enter into this First Amendment
to Lease for the purposes hereinafter set out.

         NOW, THEREFORE, in consideration of the premises and other good and
valuable consideration, the receipt and sufficiency of which is hereby
acknowledged, the parties hereto agree as follows:

1.       Article 2 of the Lease captioned "Term" is hereby modified to extend
         the term of the Lease for sixty eight (68) months, commencing on July
         1, 1998 and expiring on March 31, 2004.

2.       (a) Article 3 of the Lease captioned "Rent" is hereby modified as of
         February 1, 1997 to change the annual Initial Base Rent payable under
         the Lease from and after the February 1, 1997 to Two Hundred
         Forty-Four Thousand Seven Hundred Sixty-Two and 50/100 Dollars
         ($244,762.50) payable in equal monthly installments of Twenty Thousand
         Three Hundred Ninety-Six and 88/100 Dollars ($20,396.88).

         (b) Commencing on February 1, 1998 and on the first day of every Lease
         Year (as hereinafter defined) thereafter during the term hereof, the
         Initial Base Rent (without deduction for rent abatement, if any) shall
         be increased to an amount equal to one hundred three percent (103%) of
         the amount of the Initial Base Rent which was in effect during the
         Lease Year immediately preceding the Lease Year for which the
         adjustment is being made, payable by Tenant in equal monthly
         installments in accordance with Article 3 of the Lease.

         (c) For the purpose of calculating the adjustment to the Initial Base
         Rent under this First Amendment to Lease, the "Lease Year" shall be
         defined to mean a period of twelve (12) calendar months and the first
         Lease Year shall commence on February 1, 1997 and each succeeding Lease
         Year shall commence on the anniversary date of the beginning of the
         first Lease Year.

3.       Article 5 of the Lease captioned "Annual Operating Costs" is hereby
         Modified to change the Tenant's estimated monthly payment of Annual
         Operating Costs to $6,053.79 per month.

4.       Special Stipulation 47 of the Lease is hereby deleted in its entirety
         effective February 1, 1997. Special Stipulation 52 is hereby deleted in
         its entirety.

5.       Landlord will provide Tenant with a construction allowance
         ("Construction Allowance") equal to the lesser of (a) the actual amount
         expended by Tenant in remodeling and renovating the Demised Premises or
         (b) $127,276.50 as an allowance toward construction of Tenant
         Improvements in the Demised Premises. Upon request to the Landlord, the
         Tenant Improvements performed in space leased by the Tenant at 205,207
         and 209 Perry Parkway in Avenel Business Park shall qualify for the
         Construction Allowance. The Construction Allowance shall be payable
         after February 1, 1998 within thirty (30) days after request of Tenant
         and completion of all of the requirements specified below. Tenant
         Improvements shall include architectural/engineering fees, permit and
         inspection fees, and construction costs for alterations to or
         additional improvements of the partitions, doors, ceilings, finishes,
         mechanical equipment, electrical system, sprinkler system or other such
         permanent



<PAGE>



         improvements to the Demised Premises. Prior to commencement of Tenant
         Improvements, Tenant shall submit plans and specifications for the
         Tenant Improvements for the Landlord's review and approval, in
         accordance with Articles 8 and 9 of the Lease. The Tenant Improvements
         shall be performed in accordance with the following requirements:

         A. The Tenant shall provide lien waivers and copies of paid invoices
         from all contractors, subcontractors and suppliers of materials for all
         Tenant Improvements. Such invoices shall total or exceed the amount the
         Construction Allowance requested.

         B. Tenant shall provide its own contractors to perform all of the
         Tenant Improvements except that Tenant shall utilize the Landlord's
         roofing contractor for all roofing work or work involving penetrations
         of the roof membranae.

         C. The contractors, subcontractors or laborers employed in connection
         with such work shall comply with any applicable law and reasonable
         uniform work rules and regulations established by Landlord from time to
         time for all tenant improvements.

         D. Tenant, or its contractors and their subcontractors, shall provide
         such insurance, bonding, or indemnification as Landlord may reasonably
         require for its protection from negligence or malfeasance on the part
         of such contractors and subcontractors.

         E. In Landlord's reasonable judgement such work of the contractor or
         subcontractors will not result in delays, stoppages or other action or
         the threat thereof which may interfere with or delay the completion of
         other work in the Building.

         F. Landlord shall have the fight to inspect the Tenant's work on a
         regular basis.

         G. Tenant shall be responsible for obtaining any permits, certificates,
         or approvals from any state, federal or local government necessary to
         enable Tenant to occupy the Demised Premiss and construct the Tenant
         Improvements. All costs incurred in connection with obtaining such
         permits, certificates, or approvals shall be the sole responsibility of
         Tenant.

         H. As provided for in section 9 of the Lease, Tenant shall save
         Landlord harmless from and against all expenses, liens, claims or
         damages to either property or person which may or might arises by
         reason of making the Tenant Improvements.

         I. If after complying with the terms of this Paragraph 5, the
         Construction Allowance is not paid in accordance with the terms of this
         Paragraph 5, then Tenant shall be entitled, notwithstanding anything in
         the Lease to the contrary to offset the rent by an amount equal to the
         Construction Allowance.

6.       A. Prior to February 1, 1997, and within ninety (90) days after the
         expiration or earlier termination of the Lease, Landlord may engage its
         environmental consultant, Environmental Management Group or another
         environmental consultant satisfactory to Landlord to perform a Phase I
         environmental assessment of the Demised Premises and any surrounding
         areas of the Property designated by Landlord or the Environmental
         Consultant. The cost of the above described Phase I assessments shall
         be paid by Landlord unless the assessment indicates that Tenant is not
         in substantial compliance with the applicable statues, ordinances, and
         regulations governing Tenant's use, storage, and disposal of chemicals
         and hazardous materials in which event Tenant shall reimburse Landlord
         as additional rent for the cost of the assessment. Tenant shall defend,
         indemnify, and hold Landlord and Landlord's agents, officers,
         directors, employees, and contractors harmless against and from any and
         all injuries, costs, expenses, liabilities, losses, damages,
         injunctions, suits, actions, fines, penalties, and demands of any kind
         or nature (including reasonable attorney fees) occasioned by or arising
         out of or relating to any environmental pollution, damage, condition or
         problem, including without limitation, the presence of any hazardous
         substances, asbestos or other toxic waste as defined in any federal,
         state, or municipal governmental or quasi-governmental laws, rules,
         regulations, or ordinances in effect on the Lease Date that are
         existing in the Demised Premises and caused by the acts, omissions or
         negligence of Tenant, its agents, or employees and not caused by
         Landlord's acts or omissions.



<PAGE>



         B. Landlord shall have the right, at its sole cost and not as an
         operating expense, on one (1) occasion during each Lease Year to have
         Landlord's environmental consultant inspect the Tenant's records and
         procedures regarding the Tenant's storage, use, and disposal of
         chemicals and hazardous materials within the Demised Premises. In the
         event that the Landlord's environmental consultant finds that the
         Tenant is not in substantial compliance with any applicable law,
         regulation, or codes regarding the storage, use, or disposal of
         chemicals or hazardous materials, such non compliance shall constitute
         a non-monetary default under Article 16 of the Lease.

         D. Tenant shall have the right to construct an exterior structure
         (Outdoor Storage Structure) in a location and of a size and material
         reasonably approved by Landlord within which Tenant will store
         chemicals and materials which are subject to this Paragraph 6. The
         Construction Allowance may be used for this purpose. The Outdoor
         Storage Structure shall be deemed to be a part of the Demised Premises
         for purposes of Articles 8, 9, 12, 13, 17, 18, 20, 21, and 23 of this
         Lease and Tenant shall include the Outdoor Storage Structure within the
         coverage of all insurance policies required to be maintained by Tenant
         under this Lease.

7.       Tenant shall have the option to renew the term of the Lease for one (l)
         additional period of five (5) years (the "Option Term") following the
         expiration of the initial lease term provided for in paragraph 1 of
         this First Amendment, provided that the Lease is in full force and
         effect, the Tenant shall be in possession and occupying the Demised
         Premises, and Tenant shall not be in default in the performance or
         observance of any of the terms, conditions, provisions and/or covenants
         of the Lease. All such rights of a renewal shall be exercised by
         delivery to Landlord of written notice of Tenant's intention to renew
         the term at least nine (9) months but not more than fifteen (15) months
         prior to the expiration of the then applicable term of the lease. The
         Option Term shall be on the same terms, covenants and conditions as the
         original lease except Initial Base Rent for the Option Term shall be
         100% of the then Prevailing Market Rent of comparable space within the
         Gaithersburg market area, including current operating costs and
         concessions, which rent shall be established as follows:

         (a) Within fifteen (15) business days after receipt of Tenant's notice
         exercising its option to extend the term of this Lease, Landlord shall
         notify Tenant of Landlord's estimate of Prevailing Market Rent. If
         Tenant disagrees with Landlord's estimate of Prevailing Market Rent,
         Tenant shall notify Landlord that it has elected to submit the
         determination of Prevailing Market Rent to Arbitration, in which event
         the provisions of subparagraph (b) of this Article shall govern the
         selection of arbitrators and the establishment of the Prevailing Market
         Rent payable for the year of the then applicable Option Term; provided,
         however, that if Tenant does not elect to submit the determination of
         Prevailing Market Rent to Arbitration during such fifteen (15) day
         period, then the Landlord's estimate of Prevailing Market Rent shall be
         deemed to be agreed to by Tenant, and shall be the Initial Base Rent
         payable by Tenant to Landlord during the first year of the then
         applicable Option Term.

         (b) (i) Definition: As used herein, the term "Prevailing Market Rent"
         means the most probable rent (as determined pursuant to the appraisal
         procedure hereinafter set forth) at which the Demised Premises (and any
         Additional Premises) would be leased in a comparable and open
         market, under all conditions requisite to a fair Lease, the Landlord
         and Tenant each acting prudently, knowledgeable, and assuming the rent
         is not affected by undue stimulus. Implicit in this definition is the
         consummation of the Lease beginning on the commencement date of the
         Option Term under conditions whereby:

         1. Landlord and Tenant are typically motivated (i.e., neither party is
         compelled to enter into a lease and both parties are willing to enter
         into a lease).

         2. Both parties are well informed or well advised, and each acting in
         what it considers its own best interest.

         3. A reasonable time is allowed for exposure in the open market.

         4. The Prevailing Market Rent shall be computed as an amount equal to
         the then prevailing market rental rate of the Demised Premises, as if
         vacant with building standard



<PAGE>



         improvements, and taking into account the annual adjustments of Initial
         Base Rent, Tenant's obligation to pay Tenant's pro-rata share of Annual
         Operating Expenses and all existing market factors.

         5. All of the terms, covenants and conditions of the Lease (except
         terms respecting the amount of Initial Base Rent) remain in effect
         throughout the applicable Option Term.

         (ii) In the event of a dispute as to determination of Prevailing Market
         Rent referred to in this Article, or a dispute of any of the provisions
         of this Lease, such dispute shall be in accordance with the following:

         (a) If Landlord and Tenant fail to agree upon the Prevailing Market
         Rent as referred to in this Article, within the time periods provided
         for herein, then Landlord and Tenant each shall give notice to the
         other setting both the name and address of a licensed real estate
         broker or appraiser (hereinafter "appraiser") who shall be a M.A.I.
         Real Estate professional with substantial experience in commercial real
         estate appraisal designated by it to make the determinations hereafter
         required. Each appraiser shall be instructed to calculate the
         Prevailing Market Rent as provided in each of the foregoing sections
         which is the subject of the dispute and is in accordance with the
         criteria referenced therein. If either party shall fail to give notice
         of such designations within ten (10) days after failing to agree
         between themselves, then the appraisal made by the appraiser so
         designated shall be the Appraisal Prevailing Market Rent. If two
         appraisers have been designated, such two appraisers shall consult with
         each other and, within thirty (30) days thereafter, issue their
         determinations of Appraisal Prevailing Market Rent in writing, and give
         notice thereof to each other and to Landlord and Tenant. If such two
         appraisers shall concur as to the determination of the prevailing
         Market Rent and submit their decision in writing to Landlord and
         Tenant, such concurrence shall be final and binding upon Landlord and
         Tenant. If the two determinations of Prevailing Market Rent shall be
         within five percent (5%) (measured from the higher appraisal) of each
         other, the Prevailing Market Rent shall be deemed to be the average of
         the two appraisers' determinations. If such two appraisers'
         determinations shall not so concur or coincide, then such two
         appraisers shall immediately (i) designate a third appraiser, (ii)
         prepare detailed written appraisals, and (iii) submit copies of such
         appraisal to Landlord, Tenant and such third arbitrator. If the two
         appraisers shall fail to agree upon the designation of such third
         appraiser within eight (8) days of the date on which the last
         determination was rendered, then either party may apply to the American
         Arbitration Association or any successor thereto having jurisdiction,
         for the designation of such appraiser. All arbitrators shall be
         licensed real estate appraisers who shall have had at least fifteen
         (15) years continuous experience in the business of appraising or real
         estate in the Montgomery County area. The third appraiser shall conduct
         such hearings and investigations as he may deem appropriate and shall,
         within twenty (20) days after the date of designation of the third
         appraiser, choose the determination of the two appraisers originally
         selected by the parties which is the nearest to the determination such
         third appraiser would have made acting alone and applying the standards
         set forth therefor in this Lease, and that choice by the third
         appraiser shall be binding upon Landlord and Tenant. Each party shall
         pay its own counsel fees and expenses, if any, in connection with any
         arbitration under this Article, including the expenses and fees of any
         appraiser selected by it in accordance with the provisions of this
         Article, and the parties shall share equally all other expenses and
         fees of any such arbitration, including the expenses of the third
         appraiser. The determination rendered in accordance with the provisions
         of this Article shall be final and binding in fixing the Prevailing
         Market Rent. Notwithstanding the foregoing, in no event shall the Basic
         Rent for the First Lease Year of the Option Term be less than the then
         Initial Base Rent of the last Lease Year of the initial lease term of
         this First Amendment escalated by three percent.

8.       Landlord will use reasonable efforts to obtain a non-disturbance
         agreement for Tenant's benefit from the holder of the mortgage lien on
         the Property (the "Lender"). The non-disturbance agreement shall be on
         the Lender's approved form, and Tenant shall pay to Landlord, as
         additional rent, all fees, costs and expenses charged to Landlord by
         the Lender in connection with the Lender's review of this Lease
         including, without limitation, the Lender's legal fees. This Lease
         shall not be subordinate to any future mortgage, deed of trust



<PAGE>



         or other lien on the Property unless the party secured by any such
         instrument enters into a non-disturbance agreement with Tenant on a
         form acceptable to such future Lender.

9.       Except as modified hereby, the Lease shall remain in full force and
         effect in accordance with its terms, and is hereby ratified, confirmed
         and approved in all respects.

WITNESS the following signatures and seals.

ATTEST:                             LANDLORD:SAUL HOLDINGS LIMITED PARTNERSHIP
                                    By: SAUL CENTERS, INC., ITS GENERAL PARTNER


       [SIG]                        By:/s/ PHILIP D. CARACI
- ---------------------------            ------------------------------------
(SEAL)     Secretary                   Philip D. Caraci, President

ATTEST:                             TENANT:  ONCOR, INC.

        [SIG]                       By:
- ---------------------------            ------------------------------------
(SEAL)     Secretary



<PAGE>

                                    EXHIBIT A



   RG      0101       AMPICILLIN
   RG      0102       AMMONIUM ACETATE
   RG      0103       ACETIC ACID
   RG      0104       AGAROSE SEAKEM LE
   RG      0105       ANTIFOAM A DCA ANTIFOAM
   RG      0106       AMMONIUM PERSULFATE
   RG      0107       ACRYLAMIDE
   RG      0108       3AMINOPROPYLTRIEIHOXY-
                         SILANE
   RG      0109       ACETIC ANHYDRIDE
   RG      0110       AGAROSE NUSIEVE
   RG      0111       ALKALINE PHOPHATASE
   RG      0112       AMMONIUM CHLORIDE
   RG      0113       AMMONIUM SULFATE
   RG      0114       AGAROSE HISPANAGAR
   RG      0116       AGAR STRIPS-TOTAL COUNT
                         (GK-4)
   RG      0120       ANTIBODY MOUSE IgG ANTI-
                         DIGOXYGENIN
   RG      0125       ANTI-DIGOXIGENIN
                         PEROXYDASE 150u/ml
   RG      0130       ALUMINUM SUL. HYDRATED
   RG      0135       ANTIBODY-FITC ANTIDIG
   RG      0136       ANTIBODY FITC ANTIPHOX
   RG      0140       ANTIBODY-FITC ANTI
                         RABBIT
   RG      0145       ANTIBODY TEXAS RED ANTI-
                         AVIDIN
   RG      0150       ANTIBODY-RABBIT ANTI-
                         SHEEP
   RG      0155       ANTIBODY-RHODAMINE ANTI-
                         RABBIT
   RG      0160       ALCONOX DETERGENT
   RG      0200       BACTO-AGAR
   RG      0201       TRYPTONE(BACTO)
   RG      0202       YEAST EXTRACT (BACTO)
   RG      0203       B-MERCAPTOETHANOL
   RG      0204       BROMOPHENOL BLUE
   RG      0205       BORIC ACID GRANULAR
   RG      0206       BISACRYLAMIDE
   RG      0207       5BROMO4CHLORO3INDOLYLP-
                         HOSPHATE
   RG      0208       BCR-PROBE
   RG      0209       BENZAMIDINE
   RG      0220       BLUE BUFFER SOLUTION
   RG      0300       CASEIN,VITAMIN FREE
   RG      0301       CHLOROFORM
   RG      0302       CALCIUM CHLORIDE
   RG      0303       CARNATION NONFAT DRY MILK
   RG      0304       CASEIN FROM BOVINE MILK
   RG      0305       CASEIN HAMMERSTEIN
   RG      0306       INACTIVE
   RG      0307       CADAVERIN
   RG      0308       CHAPS
   RG      0309       HUMAN COZ-1 DNA
   RG      0311       MDA-MB468 CELL PELLET
   RG      0315       CENTRICON MINI CONTRACT
   RG      0400       DAB STOCK SOLUTION
   RG      0401       DAPI
   RG      0402       DEXTRAN SULFATE
   RG      0403       DITHIOTHREITOL (DTT)
   RG      0404       NUCLEOTIDE-dCTPALPHA 32p
   RG      0405       NUCLEOTIDE-dATP
   RG      0406       NUCLEOTIDE-dTTP


<PAGE>


   RG      0407   NUCLEOTIDE-dGTP
   RG      0408   ENZYME-DNAse I
   RG      0409   ENZYME-DNA POLYMERASE I
                     (10 U/ul)
   RG      0410   DISUCCINIMIDYL SUBERATE
                     (DSS)
   RG      0411   DIETHNYLPYROCARBONATE
   RG      0412   DIMETHYLFORMAMIDE(DMF)
   RG      0413   NUCLEOTIDE-dCTP
   RG      0414   NUCLEOTIDE-dUTP BIOTIN
   RG      0415   OBEA BIO-14-DCTP
   RG      0417   NUCLEOTIDE-dUTP DIG
   RG      0418   DIGOXIGENIN-14-dCTP
                     NUCLEOTIDE
   RG      0419   DIGOXIGENIN-11-UTP
   RG      0420   NUCLEOTIDE-dNTP SET
   RG      0421   DEIONIZED WATER
   RG      0422   NUCLEOTIDE:BODIPY-TR-
                     dCTP
   RG      0425   2,4-DINITROBENZENESULFON
                     IC ACID, SODIUM SALT
   RG      0426   DIETHUNOLAMINE
   RG      0501   EDTA
   RG      0502   ETHANOL
   RG      0503   ETHIDIUM BROMIDE
   RG      0504   ETHER
   RG      0505   E.coli tRNA
   RG      0506   EGTA
   RG      0520   EOSIN Y
   RG      0601   FORMAMIDE
   RG      0602   FICOLL
   RG      0603   FITC AVIDIN
   RG      0604   FORMALDEHYDE
   RG      0605   FORMALIN SOLUTION
                     NEUTRAL BUFFERED
   RG      0701   GLYCEROL
   RG      0702   GLUCOSE
   RG      0703   GLYCINE
   RG      0704   GIEMSA STAIN
   RG      0705   GLACINE
   RG      0706   ANTIBODY-GOAT ANTI-
                     AVIDIN
   RG      0707   GOAT SERUM
   RG      0708   GUANIDINE THIOCYANATE
   RG      0800   HB101 COMPETENT CELLS
   RG      0801   HYDROCHLORIC ACID
   RG      0802   HEMATALL
   RG      0803   HYDROXYAPATITE
   RG      0804   HEPES
   RG      0805   HIPURE GELATIN
   RG      0806   HEMTOXYLIN
   RG      0810   HORSERADISH PEROXIDE
                     COMPLEX
   RG      0820   HYDROGEN PEROXIDE
   RG      0901   ISOAMYL ALCOHOL
   RG      0905   ISOPROPYL ALCOHOL
   RG      1102   KODAK FIXER LIQUID
   RG      1103   KODAK DEKTOL DEVELOPER
   RG      1210   LYSOZYME
   RG      1215   STABILZYME
   RG      1220   LB/AMPICILLIN PLATES
   RG      1230   LIQUINOX
   RG      1235   LpH GERMICIDAL DETERGENT


<PAGE>

   RG      1236   LITHIUM CHLORIDE
   RG      1300   MAGNESIUM ACETATE
   RG      1301   MAGNESIUM CHLORIDE
                     HEXAHYDRATE
   RG      1302   INACTIVE
   RG      1303   METHANOL
   RG      1304   MINERAL OIL
   RG      1305   1.OM MgCl
   RG      1310   MOPS SODIUM SALT
   RG      1315   MOUNTING MEDIA
   RG      1320   ENZYME-MSP I(100U/ul)
   RG      1402   NACS 20
   RG      1403   NACS 37
   RG      1404   NITRO BLUE TETRAZOLIUM
   RG      1405   NONIDET P-40
   RG      1420   NHS LC BIOTIN
   RG      1480   NUCLEAR FAST RED
   RG      1501   NUCLEOTIDE OLIGODEOY-
                     NUCLEOTIDE MIXTURE
   RG      1502   TS OLIGONUCLEOTIDE
   RG      1503   ACX OLIGONUCLEOTIDE
   RG      1504   UZ OLIGONUCLEOTIDE
   RG      1505   TSUZ OLIGONUCLEOTIDE
   RG      1506   TSR8 OLICG1ONUCLEOTIDE
   RG      1601   POTASSIUM PHOSPHATE
                     DIBASIC
   RG      1602   POTASSIUM PHOSPHATE
                     MONOBASIC
   RG      1603   POTASSIUM ACETATE
   RG      1604   POTASSIUM CHLORIDE
   RG      1605   POLYVINYL PYROLLIDINE
   RG      1606   POTASSIUM HYDROXIDE
   RG      1607   PEG 8000
   RG      1608   PHENOL (LIQUID)
   RG      1609   P-PHENYLENE DIAMINE DI-
                     HYDROCHLORIDE
   RG      1610   PARAFORMALDEHYDE
   RG      1611   PEPTONE WATER
   RG      1612   PERMOUNT
   RG      1613   PROTEASE SUBSTRATE GEL
                     TABLET
   RG      1615   PROPIDIUM IODIDE
   RG      1616   PROPYLPARASEPT
   RG      1617   PHENOL CRYSTALS
   RG      1618   PHENOL, CHLORROFORM
                     ISOAMYL ALCOHOL
   RG      1619   P11 FIBROUS CATION EX-
                     CHANGER
   RG      1620   POLYETHYLENE GLYCOL
   RG      1640   PNPP TABLETS
   RG      1801   RABBIT SERUM NORMAL
   RG      1805   RHODAMINE ANTI DIG
   RG      1823   RED BUFFER SOLUTION pH4
   RG      1829   REX-70 200-400 MESH
                     SODIUM/BIO
   RG      1843   RODAC PLT-TSA AGAR
                     LECITHI & P80
   RG      1901   SODIUM CHLORIDE
   RG      1902   SODIUM HYDROXIDE PELLETS
   RG      1903   SODIUM DODECYL SULFATE
   RG      1904   SODIUM PHOSPHATE
                     DIABASIC-ANHYDROUS
   RG      1906   SODIUM CITRATE
   RG      1907   SODIUM ACETATE
   RG      1908   SARCOSYL(N-LAUROYLSAR-
                     COSINE)
   RG      1909   SPERMIDINE


<PAGE>

   RG      1910   SEPHADEX G-50
   RG      1911   SALMON SPERM DNA
   RG      1912   SEPHADEX G-25
   RG      1913   SODIUM PHOSPHATE-
                     DIBASIC
   RG      1914   SODIUM PHOSPHATE MONO-
                     BASIC-MONOHYDRATE
   RG      1915   SODIUM AZIDE
   RG      1916   SODIUM BICARBONATE
   RG      1917   SODIUM CARBONATE
   RG      1918   SODIUM DIATRIZOATE
   RG      1919   SODIUM PHOSPHATE BUFFER
                     POWDER
   RG      1920   STERILE WATER
   RG      1921   STREPTAVIDIN STOCK
   RG      1922   SUCROSE
   RG      1923   SODIUM BISULFITE
   RG      1930   STAIN BUFFER PELLET
   RG      1940   SEPHAROSE CL-4B
   RG      2001   TRIS BASE
   RG      2003   TRIS HYDROCHLORIDE
   RG      2004   TRITON X-100
   RG      2005   TEMED
   RG      2006   TRIETHANOLAMINE
   RG      2007   TRIS ACETATE
   RG      2008   INACTIVE
   RG      2009   INACTIVE
   RG      2010   TWEEN 20
   RG      2011   tris-cl (ph8.3)
   RG      2012   TRIS-CL (PH7.6)
   RG      2030   THYMOL
   RG      2040   ENZYME Taq 1 POLYMEARSE
                     5U/ul
   RG      2101   UREA
   RG      2205   VESPHENE/1 STROKE GERMIC
                     DETER
   RG      2250   WRIGHT STAIN
   RG      2401   XYLENE CYANOL
   RG      2505   YELLOW BUFFER SOLUTION
                     pH7
   RG      2610   ZINC CLORIDE
   RG      2702   BLEACH
   RG      2703   DIALYSIS MEMBRANE-3/4 IN
   RG      2704   CONDUCT CAL SOLUTION
                     1000umhos/cm
   RG      2705   CONDUCT CAL SOLUTION
                     10000umhos/cm
   RG      2706   CONDUCT CAL SOLUTION
                     100000umhos/cm
   RG      2707   PONCEAU SS
   RG      2708   PONCEAU S
   RG      2709   ACID FUCHSIN
   RG      2711   COOMAISE BRILLIANT BLUE
                     R250
   RG      2712   METHYL GREEN
   RG      2713   METHYL VIOLET 2B
   RG      2714   METHYL BLUE
   RG      2715   ORANGE G
   RG      2716   METHYL ORANGE
   RG      2717   NAPHTHOL BLUE BLACK
   RG      2718   NILE BLUE A
   RG      2719   MOLT 4 CELLS
   RG      2720   SB CELLS
   RG      2721   PLACENTA FEMALE
                     (SHADY GROVE)
   RG      2722   PLACENTA MALE
                     (SHADY GROVE)


<PAGE>

   RG      2724   COBALT CHLORIDE HEXA-
                     HYDRATE
   RG      2725   CACODYLIC ACID
   RG      2726   ENZYME-DEOXYNUCLEOTIDE
                     TERM.  TRANSFERASE 25u/ul
   RG      2727   KANAMYCIN MONOSULFATE
   RG      2728   CARBOXYMETHLATED BSA
   RG      2729   ANTIBODY-PCNA
   RG      2730   ANTIBODY NM23
   RG      2731   S35 dUTP
   RG      2732   ANTI-DIGOXIGENIN
                     ALK-PHOSPHATASE
   RG      2734   L-GLUTAMINE
   RG      2735   RPMI-1640 MEDIUM WITH
                     HEPES
   RG      2736   PHYTOHAEMAGGLUTININ
   RG      2737   DEIONIZED DISTILLED
                     WATER
   RG      2738   PENICILLIN-STREPTOMYCIN
                     SOLUTION
   RG      2739   COLCEMID (KAYROMAX)
   RG      2740   FETAL BOVINE SERUM
   RG      2741   ACETONE
   RG      2742   XYLENES
   RG      2743   BIOTINYLATED ANTI-SHEEP
                     Ab
   RG      2744   THIMERSOL
   RG      2745   HRP ANTI-DIGOXYGENIN
   RG      2746   HER-2/NEU ANTIBODY
   RG      2750   ACETIC ACID, GLACIAL
   RG      2751   AMMONIUM HYDROXIDE SON
   RG      2752   AMMONIUM OXALATE
   RG      2753   BARIUM CHLORIDE
                     DIHYDRATE
   RG      2754   CALCIUM HYDROXIDE
   RG      2755   HYDROGEN SULFIDE
   RG      2756   NITRIC ACID 1.0 N
   RG      2757   NESSLER'S REAGENT
   RG      2758   POTASSIUM CHLORIDE
   RG      2759   SILVER NITRARE 1.0 N
   RG      2760   SULFURIC ACID 36N
   RG      2761   HIGHLY PURIFIED WATER
   RG      2762   SODIUM CHLORIDE
   RG      2763   POTASSIUM PERMANGANATE
                     1 ON
   RG      2764   ALUI ENZYME
   RG      2765   RANDOM HEXANUCLEOTIDE
                     FRAGMETS pd(N)6
   RG      2766   HISTOCHOICE TISSUE
                     FIXATIVE 100ml
   RG      2767   HISTOCHOICE TISSUE
                     FIXATIVE 500ml
   RG      2768   HISTOCHOICE TISSUE
                     FIXATIVE 4 LITER
   RG      2769   HISTOCHOICE TISSUE
                     FIXATIVE 3ml
   RG      2770   HISTOCHOICE TISSUE
                     FIXATIVE 7ml
   RG      2771   HISTOCHOICE TISSUE
                     FIXATIVE 15ml
   RG      2772   ANTI-HUMAN FAS, CLONE
                     CH-11, 50ug
   RG      2773   ANTI-HUMAN FAS, UB2
                     100ug
   RG      2774   ANTI-HUMAN FAS, UB2-FITC
                     LABELED, 50 TESTS
   RG      2775   SODIUM SULFITE PHOTO-
                     GRAPHIC GRADE
   RG      2776   FITC-11-dUTP
   RG      2777   SYNERGEL
   RG      2778   CATRIMOX-14
   RG      2779   ICE INHIBITOR
   RG      2780   ICE SUBSTRATE
   RG      2781   GRANZYME B SUBSTRATE
   RG      2782   GRANZYME B SUBSTRATE INHIBITOR


<PAGE>

   RG      2783   ICE OVERLAY MEMBRANE
   RG      2784   GRANZYME B ENZYME OVER-
                   LAY MEMBRANE
   RG      2785   AGAROSE DI LE
   RG      2786   AGAROSE DS LE
   RG      2787   AGAROSE LM2
   RG      2788   MOPS FREE ACID
   RG      2789   ANTI-EGER ANTIBODY
   RG      2790   ANTI-FLUORESCEIN AP FAB FRAGMENTS
   RG      2791   PRE-PACKED PD10 COLUMN
   RG      2792   EGFR PEPTIDE
   RG      2793   FAE-dCTP
   RG      2794   EGFR ANTIBODY
   RG      2795   ISO ENZYME muGST
   RG      2796   GST ALPHA ISOENZYME
   RG      2797   EGFR ISOENZYME
   RG      2798   GST mu ANTIBODY
   RG      2799   GST ALPHA ANTIBODY
   RG      2801   LAMBDA HIND III DNA
   RG      2802   PHI X 174-HAE III DNA
   RG      2803   REACT BUFFER SET
   RG      2804   ENZYME Sst I
   RG      2805   ENZYME Pst I 50U/ul
   RG      2806   LAMBDA DNA
   RG      2807   PBR322-DNA
   RG      2808   PROTEINASE K
   RG      2809   ENZYME-Pst I 10U/ul
   RG      2810   ENZYME-BamH I 50U/ul
   RG      2811   ENZYME-HINC II (10 U/ul)
   RG      2812   ENZYME-AVA I
   RG      2813   ENZYME SAU3A
   RG      2814   BSA (ACETYLATED) SOLUTION
   RG      2816   ENZYME DDE I
   RG      2817   HERRING TESTES DNA
   RG      2818   RNASE A
   RG      2819   RNASET T
   RG      2820   ENZYME ECOR I 50U/ul
   RG      2821   ENZYME KLENOW FRAGMENT
   RG      2823   123 bp DNA LADDER
   RG      2824   ENZYME ECOR V
   RG      2825   ENZYME CLA I
   RG      2826   ENZYME AAT II
   RG      2827   ENZYME BGL I
   RG      2828   ENZYME AVA II
   RG      2829   ENZYME BAMH I 100U/ul
   RG      2830   ENZYME HIND III 50U/ul
   RG      2831   BSA POWDER
   RG      2832   ANTIBODY-GstPI
   RG      2833   ENZYME HINC II
   RG      2834   ENZYME HIND III 100U/ul
   RG      2836   ENZYME DRA I
   RG      2837   ENZYME ECOR I 100U/ul
   RG      2838   ENZYME BGL II
   RG      2839   BAMH I 200U/ul
   RG      2840   ENZYME HIND III 200U/ul
   RG      2841   ECOR I 200U/ul


<PAGE>

   RG      2842   ENZYME PVU II
   RG      2843   ENZYME NDE I
   RG      2844   ENZYME SAC II 2009U/ul
   RG      2845   ENZYME HPA I
   RG      2846   ENZYME HINF I
   RG      2847   dTTP NUCLEOTIDE
   RG      2848   dGTP NUCLEOTIDE
   RG      2849   dCTP NUCLEOTIDE
   RG      2850   dATP POWDER
   RG      2851   ENZYME HIND III 8-12
                     U/ul (LTI)
   RG      2852   ENZYME ECORI 8-12 U/ul
                     (LTI)
   RG      2853   HIND III 10 U/ul
                     (APPLIGENE)
   RG      2854   ECO RI 10 U/ul
                     (APPLIGENE)
   RG      2855   ENZYME KPN I
   RG      2856   BAMH I 10 U/ul
                     (APPLIGENE)
   RG      2857   ENZYME BAMH I 8-12 U/ul
                     (LTI)
   RG      2858   SAC I 10 U/ul (APPLIGENE)
   RG      2859   SAC I 8-12 U/ul(PROMEGA)
   RG      2860   BGL I 10 U/ul(APPLIGENE)
   RG      2861   DRA I 10 U/ul(APPLIGENE)
   RG      2862   PVU II 10 U/ul(APPLIGENE)
   RG      2863   ENZYME NCO I
   RG      2865   SST I 50-100 U/ul (LTI)
   RG      2866   DRA I 50 U/ul (LTI)
   RG      2867   BUFFER SET (APPLIGENE)
   RG      2868   BSA, FRACTION V HEAT
                     SHOCK
   RG      2870   TAKARA LA PCR
   RG      2871   TAKARA PCR AMPLIFICATION
   RG      2872   TAKARA TAQ POLYMARASE
   RG      2873   TAKARA TAQ POLYMARASE
   RG      2874   TAKARA LA PCR KIT VER 2
   RG      2875   TAKARA LA PCR CLONING
   RG      2876   TAKARA LA PCR MUTAGENSIS
   RG      2877   TAKARA CDNA SYNTHESIS
                     KIT
   RG      2878   TAKARA PCR MYEOPLASMA
                     DETECTION
   RG      2879   TAKARA RNA PCR KIT VER 2
   RG      2880   DNA QUANTITATION STAND-
                     ARDS
   RG      2882   ENZYME ECORI 50U/ul
   RG      2883   ENZYME HIND III 50U/ul
   RG      2884   ENZYME BAMHI 50U/ul
   RG      2885   ENZYME PVU I
   RG      2886   ENZYME DRAI 50U/ul
   RG      2891   ENZYME SAL I
   RG      2892   ENZYME SAU96 I
   RG      2893   ENZYME SCA I
   RG      2894   Enzyme Sph I
   RG      2896   ENZYME SCA II
   RG      2897   ENZYME Taq I
   RG      2898   ENZYME XHO 1
   RG      2900   ENZYME XBA I
   RG      2901   ANTI-FLUORESCEIN
   RG      2902   ANTI-MOUSE FLUORESCEIN
                     CONJUGATE
   RG      2903   TRYPSIN INHIBITOR
                     (SOYBEAN)
   RG      2904   RABBIT ANTI-DNP ANTIBODY
   RG      2905   OVALBUMIN


<PAGE>

   RG      2906   TRIFLOR ACETIC ACID
   RG      2907   CARBONIC ANHYDRASE II
   RG      2908   PHOSPHORYLASE B
   RG      2909   GOAT ANTI-RABBIT IgG HRP
                     ANTIBODY
   RG      2910   1.4-DINITROPHENYLHY-
                     DRAZINE
   RG      2911   BOVINE SERUM ALBUMIN
   RG      2912   POTASSIUM CARBONATE
   RG      2913   TRIETHANOLAMINE -
                     CRYSTALLINE
   RG      2914   PLACENTA MALE
                     (INTERGEN)
   RG      2915   PLACENTA FEMALE
                     (INTERGEN)
   RG      2916   PHENYLOXAZOLINE-DCTP
   RG      2917   BOVINE THROMBIN
   RG      2918   BOVINE PLASMA
   RG      2930   ENVIROCIDE

<PAGE>
                      THIRD AMENDMENT TO THE LEASE BETWEEN
                        SAUL HOLDINGS LIMITED PARTNERSHIP
                                 AND ONCOR, INC.
                                209 PERRY PARKWAY

     This THIRD AMENDMENT TO LEASE is made and entered into this 15th day of
October, 1996 by and between SAUL HOLDINGS LIMITED PARTNERSHIP (hereinafter
referred to as "Landlord"), successor in interest to Avenel Associates Limited
Partnership, and ONCOR, INC. a Maryland Corporation (hereinafter referred to as
"Tenant"),

         WHEREAS, Landlord and Oncor, Inc., have entered into that certain Lease
dated March 22, 1990 as amended by an Amendment to Lease dated February 25, 1991
and the Second Amendment to Lease dated June 21, 1991 (the "Lease") for
approximately 25,941 square feet in 209 Perry Parkway, Avenel Business Park,
Gaithersburg, Maryland 20877; and

         WHEREAS, the parties hereto desire to enter into this Third Amendment
to Lease for the purposes hereinafter set out.

         NOW, THEREFORE, in consideration of the premises and other good and
valuable consideration, the receipt and sufficiency of which is hereby
acknowledged, the parties hereto agree as follows:

1.       Article 2 of the Lease captioned "Term" is hereby modified to extend
         the term of the Lease for eighty-four (84) months, commencing on April
         1, 1997 and expiring on March 31, 2004.

2.       (a) Article 3 of the Lease captioned "Rent" is hereby modified as of
         February 1, 1997 to change the annual Initial Base Rent payable under
         the Lease from and after February 1, 1997 to Three Hundred Twenty-Four
         Thousand Two Hundred Sixty-Two and 50/100 Dollars ($324,262.50) payable
         in equal monthly installments of Twenty-Seven Thousand Twenty One and
         88/100 Dollars ($27,021.88).

         (b) Commencing on February 1, 1998 and on the first day of every Lease
         Year (as hereinafter defined) thereafter during the term hereof, the
         Initial Base Rent (without deduction for rent abatement, if any) shall
         be increased to an amount equal to one hundred three percent (103%) of
         the amount of the Initial Base Rent which was in effect during the
         Lease Year immediately preceding the Lease Year for which the
         adjustment is being made, payable by Tenant in equal monthly
         installments in accordance with Article 3 of the Lease.

         (c) For the purpose of calculating the adjustment to the Initial Base
         Rent under this Third Amendment to Lease, the "Lease Year" shall be
         defined to mean a period of twelve (12) calendar months and the first
         Lease Year shall commence on February 1, 1997 and each succeeding Lease
         Year shall commence on the anniversary date of the beginning of the
         first Lease Year.

3.       Special Stipulation 48 of the Lease is hereby deleted in its entirety
         effective February 1, 1997. Special Stipulations 47, 49, and 53 are
         hereby deleted in their entirety.

4.       The Landlord will permit the Tenant to install, at its sole cost and
         expense, an illuminated monument sign ("Monument Sign") at the entrance
         to 207/209 Perry Parkway. Landlord shall approve the exact location,
         size, content, and design of the Monument Sign, such approval not to be
         unreasonably withheld. This work will be performed in accordance with
         the stipulations for alterations specified in Article 9 of the Lease
         and applicable codes and ordinances. Given the Monument Sign's
         prominence at an entrance to Avenel Business Park, the Tenant shall
         maintain and repair (including the prompt replacement of bulbs) the
         Monument Sign in first-class condition throughout the Lease term. The
         Monument Sign shall be deemed to be a part of the Premises for purposes
         of Articles 8, 9, 12, 13, 17, 18, 20, 21, and 23 of this Lease and
         Tenant shall include the Monument Sign within the coverage of all
         insurance policies required to be maintained by Tenant under this
         Lease.



<PAGE>



5.       Landlord will provide Tenant with a construction allowance
         ("Construction Allowance") equal to the lesser of (a) the actual amount
         expended by Tenant in remodeling and renovating the Premises or (b)
         $168,616.50 as an allowance toward construction of Tenant Improvements
         in the Demised Premises. Upon request to the Landlord, the Tenant
         Improvements performed in space leased by the Tenant at 200, 205, and
         207 Perry Parkway in Avenel Business Park or the costs of the Monument
         Sign shall qualify for the Construction Allowance. The Construction
         Allowance shall be payable after February 1, 1997 within thirty (30)
         days after request of Tenant and completion of all of the requirements
         specified below. Tenant Improvements shall include
         architectural/engineering fees, permit and inspection fees, and
         construction costs for alterations to or additional improvements of the
         partitions, doors, ceilings, finishes, mechanical equipment, electrical
         system, sprinkler system or other such permanent improvements to the
         Demised Premises. Prior to commencement of Tenant Improvements, Tenant
         shall submit plans and specifications for the Tenant Improvements for
         the Landlord's review and approval, in accordance with Articles 8 and 9
         of the Lease. The Tenant Improvements shall be performed in accordance
         with the following requirements:

         A. The Tenant shall provide lien waivers and copies of paid invoices
         from all contractors, subcontractors and suppliers of materials for all
         Tenant Improvements. Such invoices shall total or exceed the amount the
         Construction Allowance requested.

         B. Tenant shall provide its own contractors to perform all of the
         Tenant Improvements except that Tenant shall utilize the Landlord's
         roofing contractor for all roofing work or work involving penetrations
         of the roof membrane.

         C. The contractors, subcontractors or laborers employed in connection
         with such work shall comply with any applicable law and reasonable
         uniform work rules and regulations established by Landlord from time to
         time for all tenant improvements.

         D. Tenant, or its contractors and their subcontractors, shall provide
         such insurance, bonding, or indemnification as Landlord may reasonably
         require for its protection from negligence or malfeasance on the part
         of such contractors and subcontractors.

         E. In Landlord's reasonable judgement such work of contractor or
         subcontractors will not result in delays, stoppages or other action or
         the threat thereof which may interfere with or delay the completion of
         other work in the Building.

         F. Landlord shall have the right to inspect the Tenant's work on a
         regular basis.

         G. Tenant shall be responsible for obtaining any permits, certificates,
         or approvals from any state, federal or local government necessary to
         enable Tenant to occupy the Demised Premiss and construct the Tenant
         Improvements. All costs incurred in connection with obtaining such
         permits, certificates, or approvals shall be the sole responsibility of
         Tenant.

         H. As provided for in section 9 of the Lease, Tenant shall save
         Landlord harmless from and against all expenses, liens, claims or
         damages to either property or person which may or might arises by
         reason of making the Tenant Improvements.

         I. If after complying with the terms of this Paragraph 5, the
         Construction Allowance is not paid in accordance with the terms of this
         Paragraph 5, then Tenant shall be entitled, notwithstanding anything in
         the Lease to the contrary to offset against the rent an amount equal to
         the Construction Allowance.

6.       A. Tenant represents that the list attached hereto as Exhibit A is a
         complete and accurate list of chemicals and hazardous materials,
         including approximate quantities, to be used and stored in or about the
         Demised Premises. The amounts of chemicals and hazardous materials will
         be limited to quantities necessary for the Tenant's day-to-day
         operations. Landlord is relying on the list in Exhibit F in not
         requiring Gradual Pollution and/or Contamination Liability Insurance.
         If Tenant's operations change and additional chemicals materially more
         hazardous and/or quantities significantly larger than those stipulated
         in Exhibit F are required



<PAGE>

         for Tenant's operation, Tenant shall notify Landlord within five
         business days and Landlord reserves that right to require Tenant to
         obtain and maintain Gradual Pollution and/or Contamination Liability
         Insurance if in Landlord's reasonable opinion such change in the nature
         or quantity of materials being stored materially increases the risk of
         contamination. The Tenant will, upon written request by the Landlord,
         provide the Landlord with an updated list of chemicals and hazardous
         materials with quantities located within the Demised Premises.

         B. Prior to February 1, 1997, and within ninety (90) days after the
         expiration or earlier termination of the Lease, Landlord may engage its
         environmental consultant, Environmental Management Group or another
         environmental consultant satisfactory to Landlord to perform a Phase I
         environmental assessment of the Premises and any surrounding areas of
         the Property designated by Landlord or the Environmental Consultant.
         The cost of the above described Phase I assessments shall be paid by
         Landlord unless the assessment indicates that Tenant is not in
         substantial compliance with the applicable statues, ordinances, and
         regulations governing Tenant's use, storage, and disposal of chemicals
         and hazardous materials in which event Tenant shall reimburse Landlord
         as additional rent for the cost of the assessment. Tenant shall defend,
         indemnify, and hold Landlord and Landlord's agents, officers,
         directors, employees, and contractors harmless against and from any and
         all injuries, costs, expenses, liabilities, losses, damages,
         injunctions, suits, actions, fines, penalties, and demands of any kind
         or nature (including reasonable attorney fees) occasioned by or arising
         out of or relating to any environmental pollution, damage, condition or
         problem, including without limitation, the presence of any hazardous
         substances, asbestos or other toxic waste as defined in any federal,
         state, or municipal governmental or quasi-governmental laws, rules,
         regulations, or ordinances in effect on the Lease Date that are
         existing in the Demised Premises and caused by the acts, omissions or
         negligence of Tenant, its agents, or employees and not caused by
         Landlord's acts or omissions.

         C. Landlord shall have the right, at its sole cost and not as an
         operating expense, on one (1) occasion during each Lease Year to have
         Landlord's environmental consultant inspect the Tenant's records and
         procedures regarding the Tenant's storage, use, and disposal of
         chemicals and hazardous materials within the Demised Premises. In the
         event that the Landlord's environmental consultant finds that the
         Tenant is not in substantial compliance with any applicable law,
         regulation, or codes regarding the storage, use, or disposal of
         chemicals or hazardous materials, such non compliance shall constitute
         a non-monetary default under Article 16 of the Lease.

         D. Tenant shall have the right to construct an exterior structure
         (Outdoor Storage Structure) in a location and of a size and material
         reasonably approved by Landlord within which Tenant will store
         chemicals and materials which are subject to this Paragraph 6. The
         Construction Allowance may be used for this purpose. The Outdoor
         Storage Structure shall be installed, maintained, repaired and removed
         by Tenant, at Tenant's sole cost and expense, and shall be deemed to be
         a part of the Demised Premises for all purposes of the Lease including,
         without limitation, Articles 8, 9, 12, 13, 17, 18, 20, 21, and 23 of
         this Lease and Tenant shall include the Outdoor Storage Structure
         within the coverage of all insurance policies required to be maintained
         by Tenant under this Lease; provided, however, that Landlord shall not
         have any repair or maintenance obligations of any kind with respect to
         the Outdoor Storage Structure.

7.       Provided (i) Tenant is not then in default (beyond any applicable cure
         period) in any of its obligations under this Lease, and (ii) Landlord
         desires to lease the Option Space (hereinafter defined) to any party
         other than the party then occupying the Option Space, Landlord agrees
         that, during the initial term of the Lease, as extended by this Third
         Amendment to Lease, provided for in paragraph 1, Tenant shall have the
         right of first offer to enter into a lease of certain other premises in
         the Building, consisting of the area of approximately 16,241 square
         feet of leasable area contiguous to the Premises designated on Exhibit
         A as "Option Space" (the "Option Space") in accordance with the terms
         and conditions set forth in this paragraph 7, as follows:



<PAGE>



(a)      After receipt of a written proposal to lease the Option Space from a
         prospective tenant (Prospective Tenant) or its agent and prior to
         entering into a lease with that Prospective Tenant for the Option
         Space, Landlord shall send to Tenant an offer notice of the
         availability of such space (the "OFFER NOTICE").

(b)      Within ten (10) business days after Tenant's receipt of the Offer
         Notice, Tenant shall notify Landlord that Tenant either (i) agrees to
         lease the Option Space, or (ii) does not desire to lease the Option
         Space and the Landlord shall have the right to lease the Option Space
         to the Prospective Tenant. A failure by Tenant to timely elect the
         option described in clauses (i) or (ii) above shall be deemed a to be a
         waiver by Tenant of any further right to lease the Option Space under
         this paragraph 7. If Tenant elects the option described in clause (ii)
         above, the Tenant shall have additional first rights of offer provided
         that the Option Space is not leased to the Prospective Tenant or the
         Option Space becomes available during the initial term of the Lease as
         extended by this Third Amendment to Lease and subject to the initial or
         renewal occupancy by the Prospective Tenant.

(c)      If Tenant exercises its option to lease the Option Space under this
         paragraph 7, then Tenant shall execute a lease amendment embodying the
         terms set forth in the Offer Notice, within ten (10) business days
         after Landlord submits any such lease amendment to Tenant which shall
         provide that the following terms and conditions shall apply to the
         Option Space:

         (i)      The Demised Premises shall be modified effective as of the
                  date falling 40 days after the date of the Offer Notice (the
                  "Option Effective Date") to increase the size of the Demised
                  Premises by approximately 16,241 rentable square feet size.

         (ii)     As of the Option Effective Date, the initial Base Rent for
                  the Option Space shall be the Initial Base Rent per square
                  foot set forth below for the year in which Tenant exercises
                  its option under this paragraph 7 and such Initial Base Rent
                  shall be increased on the first day of each succeeding Lease
                  Year to the amounts set forth below.

                        OPTION EXERCISE DATE       RENT PER SQUARE FOOT

                        Before February 1, 1997            $12.50
                        Before February 1, 1998            $13.00
                        Before February 1, 1999            $13.50
                        Before February 1, 2000            $14.00
                        Before February 1, 2001            $14.50
                        Before-February 1, 2002            $15.00
                        Before February 1, 2003            $15.50
                        Before February 1, 2004            $16.00


         (iii)    The Annual Operating Costs shall be modified as of the Option
                  Effective Date to increase Tenant's Pro-Rata Share of Annual
                  Operating Cost to reflect the increased size of the Demised
                  Premises.

         (iv)     Tenant agrees to accept the Option Space "as is" in its then
                  existing condition and Landlord shall have no construction
                  obligations with respect thereto. However, the Landlord will
                  provide Tenant with a construction allowance ("Option Space
                  Construction Allowance") equal to the lesser of (a) the
                  actual amount expended by Tenant in remodeling and renovating
                  the Option Space or (b) an amount equal to $1,256.74
                  multiplied by the number of full months remaining on the
                  initial term of the Lease as extended by this Third Lease
                  Amendment from the Option Effective Date. The Option Space
                  Construction Allowance shall be used for the construction of
                  Tenant Improvements in the Option Space. The Construction
                  Allowance shall be payable after February 1, 1997 within
                  thirty (30) days after request of Tenant and completion of
                  all of the requirements specified below. Tenant Improvements
                  shall include architectural/engineering fees, permit and
                  inspection fees, and construction costs for alterations to
                  or additional improvements of the partitions, doors,
                  ceilings, finishes, mechanical equipment, electrical system,
                  sprinkler system or other such



<PAGE>

                  permanent improvements to the Option Space. Prior to
                  commencement of Tenant Improvements, Tenant shall submit plans
                  and specifications for the Tenant Improvements for the
                  Landlord's review and approval, in accordance with Articles 8
                  and 9 of the Lease. The provisions, requirements and
                  conditions of subparagraphs (5)(a) through (5)(i) above will
                  apply to the Option Space Construction Allowance.

(d)      Landlord may, at its option, in lieu of a narrative description of the
         terms to be described in the Offer Notice, submit to Tenant a lease
         amendment document setting forth the terms of the proposed lease
         amendment, for the Option Space in which event Tenant's exercise of its
         option to lease the Option Space shall be made by Tenant's execution of
         such lease amendment document and its return to Landlord within the
         applicable time periods set forth in paragraph (b) or (c) of this
         paragraph 7. If Landlord does not submit a lease amendment document to
         Tenant at the time the Offer Notice is given, and Tenant exercises its
         option to lease the Option Space under such terms, then Tenant shall
         execute a lease amendment embodying the terms set forth in the Offer
         Notice within ten (10) days after Landlord submits any such lease
         amendment to Tenant, as provided in paragraph (c) above.

(e)      Tenant shall have no further right to lease the Option Space under this
         paragraph 7 after Landlord enters into a lease of the Option Space with
         the Prospective Tenant in accordance with this paragraph 7 unless the
         Option Space is vacated by the Prospective Tenant during the initial
         term of the Lease as extended by this Third Lease Amendment.

(f)      Tenant's right to lease the Option Space shall be conditioned upon
         Tenant's full and complete compliance with all of the terms and
         conditions of the Lease prior to the date of any Offer Notice, and
         Tenant's option to lease the Option Space shall terminate when the
         initial term of the Lease as extended by this Third Amendment expires
         or terminates.

(g)      Time shall be of the essence with respect to Tenant's right of first
         offer under this paragraph 7.

8.       Tenant shall have the option to renew the term of the Lease for one (1)
         additional period of five (5) years (the "Option Term") following the
         expiration of the initial lease term provided for in paragraph 1 of
         this Third Amendment, provided that the Lease is in full force and
         effect, the Tenant shall be in possession and occupying the Demised
         Premises, and Tenant shall not be in default in the performance or
         observance of any of the terms, conditions, provisions and/or covenants
         of the Lease. All such rights of a renewal shall be exercised by
         delivery to Landlord of written notice of Tenant's intention to renew
         the term at least nine (9) months but not more than fifteen (15)
         months prior to the expiration of the then applicable term of the
         lease. The Option Term shall be on the same terms, covenants and
         conditions as the original lease except Initial Base Rent for the
         Option Term shall be 100% of the then Prevailing Market Rent of
         comparable space within the Gaithersburg market area, including current
         operating costs and concessions, which rent shall be established as
         follows:

         (a) Within fifteen (15) business days after receipt of Tenant's notice
         exercising its option to extend the term of this Lease, Landlord shall
         notify Tenant of Landlord's estimate of Prevailing Market Rent. If
         Tenant disagrees with Landlord's estimate of Prevailing Market Rent,
         Tenant shall notify Landlord that it has elected to submit the
         determination of Prevailing Market Rent to Arbitration, in which event
         the provisions of subparagraph (b) of this Article shall govern the
         selection of arbitrators and the establishment of the Prevailing Market
         Rent payable for the year of the then applicable Option Term; provided,
         however, that if Tenant does not elect to submit the determination of
         Prevailing Market Rent to Arbitration during such fifteen (15) day
         period, then the Landlord's estimate of Prevailing Market Rent shall be
         deemed to be agreed to by Tenant, and shall be the Initial Base Rent
         payable by Tenant to Landlord during the first year of the then
         applicable Option Term.

         (b) (i) Definition: As used herein, the term "Prevailing Market Rent"
         means the most probable rent (as determined pursuant to the appraisal
         procedure hereinafter set forth) at which the Demised Premises (and any
         Additional Premises) would be leased in a comparable and open market,
         under all conditions requisite to a fair Lease, the Landlord and Tenant
         each acting prudently, knowledgeable, and assuming the rent is not
         affected by undue stimulus.



<PAGE>



Implicit in this definition is the consummation of the Lease beginning on the
commencement date of the Option Term under conditions whereby:

1. Landlord and Tenant are typically motivated (i.e., neither party is compelled
to enter into a lease and both parties are willing to enter into a lease).

2. Both parties are well informed or well advised, and each acting in what it
considers its own best interest.

3. A reasonable time is allowed for exposure in the open market.

4. The Prevailing Market Rent shall be computed as an amount equal to the then
prevailing market rental rate of the Demised Premises, as if vacant with
building standard improvements, and taking into account the annual adjustments
of Initial Base Rent, Tenant's obligation to pay Tenant's pro-rata share of
Annual Operating Expenses and all existing market factors.

5. All of the terms, covenants and conditions of the Lease (except terms
respecting the amount of Initial Base Rent) remain in effect throughout the
applicable Option Term.

(ii) In the event of a dispute as to determination of Prevailing Market Rent
referred to in this Article, or a dispute of any of the provisions of this
Lease, such dispute shall be in accordance with the following:

(a) If Landlord and Tenant fail to agree upon the Prevailing Market Rent as
referred to in this Article, within the time periods provided for herein, then
Landlord and Tenant each shall give notice to the other setting both the name
and address of a licensed real estate broker or appraiser (hereinafter
"appraiser") who shall be a M.A.I. Real Estate professional with substantial
experience in commercial real estate appraisal designated by it to make the
determinations hereafter required. Each appraiser shall be instructed to
calculate the Prevailing Market Rent as provided in each of the foregoing
sections which is the subject of the dispute and is in accordance with the
criteria referenced therein. If either party shall fail to give notice of such
designations within ten (10) days after failing to agree between themselves,
then the appraisal made by the appraiser so designated shall be the Appraisal
Prevailing Market Rent. If two appraisers have been designated, such two
appraisers shall consult with each other and, within thirty (30) days
thereafter, issue their determinations of Appraisal Prevailing Market Rent in
writing, and give notice thereof to each other and to Landlord and Tenant. If
such two appraisers shall concur as to the determination of the prevailing
Market Rent and submit their decision in writing to Landlord and Tenant, such
concurrence shall be final and binding upon Landlord and Tenant. If the two
determinations of Prevailing Market Rent shall be within five percent (5%)
(measured from the higher appraisal) of each other, the Prevailing Market Rent
shall be deemed to be the average of the two appraisers' determinations. If such
two appraisers' determinations shall not so concur or coincide, then such two
appraisers shall immediately (i) designate a third appraiser, (ii) prepare
detailed written appraisals, and (iii) submit copies of such appraisal to
Landlord, Tenant and such third arbitrator. If the two appraisers shall fail to
agree upon the designation of such third appraiser within eight (8) days of the
date on which the last determination was rendered, then either party may apply
to the American Arbitration Association or any successor thereto having
jurisdiction, for the designation of such appraiser. All arbitrators shall be
licensed real estate appraisers who shall have had at least fifteen (15) years
continuous experience in the business of appraising or real estate in the
Montgomery County area. The third appraiser shall conduct such hearings and
investigations as he may deem appropriate and shall, within twenty (20) days
after the date of designation of the third appraiser, choose the determination
of the two appraisers originally selected by the parties which is the nearest to
the determination such third appraiser would have made acting alone and applying
the standards set forth therefor in this Lease, and that choice by the third
appraiser shall be binding upon Landlord and Tenant. Each party shall pay its
own counsel fees and expenses, if any, in connection with any arbitration under
this Article, including the expenses and fees of any appraiser selected by it in
accordance with the provisions of this Article, and the parties shall share
equally all other expenses and fees of any such arbitration,



<PAGE>


         including the expenses of the third appraiser. The
         determination rendered in accordance with the provisions of this
         Article shall be final and binding in fixing the Prevailing Market
         Rent. Notwithstanding the foregoing, in no event shall the Basic Rent
         for the First Lease Year of the Option Term be less than the then
         Initial Base Rent of the last Lease Year of the initial lease term of
         the Lease, as extended by this Third Amendment escalated by three
         percent.

8.       Landlord will use reasonable efforts to obtain a non-disturbance
         agreement for Tenant's benefit from the holder of the mortgage lien on
         the Property (the "Lender"). The nondisturbance agreement shall be on
         the Lender's approved form, and Tenant shall pay to Landlord, as
         additional rent, all fees, costs and expenses charged to Landlord by
         the Lender in connection with the Lender's review of this Lease
         including, without limitation, the Lender's legal fees. This Lease
         shall not be subordinate to any future mortgage, deed of trust or other
         lien on the Property unless the party secured by any such instrument
         enters into a non-disturbance agreement with Tenant on a form
         acceptable to such future Lender.

9.       Except as modified hereby, the Lease shall remain in full force and
         effect in accordance with its terms, and is hereby ratified, confirmed
         and approved in all respects.

WITNESS the following signatures and seals.

ATTEST:                  LANDLORD: SAUL HOLDINGS LIMITED PARTNERSHIP
                         By: SAUL CENTERS, INC., ITS GENERAL PARTNER


ATTEST:

[SIG]                    By: /s/ PHILIP D. CARACI
- ----------------------      -----------------------------------
(SEAL)    Secretary         Philip D. Caraci, President


ATTEST:                  TENANT:    ONCOR, INC.

[SIG]                    By: [SIG]
- ----------------------      -----------------------------------
(SEAL)    Secretary

<PAGE>
                      THIRD AMENDMENT TO THE LEASE BETWEEN
                        SAUL HOLDINGS LIMITED PARTNERSHIP
                                 AND ONCOR, INC.
                                207 PERRY PARKWAY


         This THIRD AMENDMENT TO LEASE is made and entered into this 15th day of
October, 1996 by and between SAUL HOLDINGS LIMITED PARTNERSHIP (hereinafter
referred to as "Landlord"), successor in interest to Avenel Associates Limited
Partnership, and ONCOR, INC. a Maryland Corporation (hereinafter referred to as
"Tenant"),

         WHEREAS, Landlord and Oncor, Inc., predecessor to Tenant, have entered
into that certain Lease dated June 28, 1991 as amended by the First Amendment to
Lease dated October 4, 1993 and the Second Amendment to Lease dated December 2,
1994 (the "Lease") for approximately 14,950 square feet in 207 Perry Parkway,
Avenel Business Park, Gaithersburg, Maryland 20877; and

         WHEREAS, the parties hereto desire to enter into this Third Amendment
to Lease for the purposes hereinafter set out.

         NOW, THEREFORE, in consideration of the premises and other good and
valuable consideration, the receipt and sufficiency of which is hereby
acknowledged, the parties hereto agree as follows:

1.       Article 2 of the Lease captioned "Term" is hereby modified to extend
         the term of the Lease for eighty-four (84) months, commencing on April
         1, 1997 and expiring on March 31, 2004.

2.       (a) Article 3 of the Lease captioned "Rent" is hereby modified as of
         February 1, 1997 to change the annual Initial Base Rent payable under
         the Lease from and after February 1, 1997 to One Hundred Eighty-Six
         Thousand Eight Hundred Seventy-Five Dollars ($186,875.00) payable in
         equal monthly installments of Fifteen Thousand Five Hundred Seventy Two
         and 92/100 Dollars ($15,572.92).

         (b) Commencing on February 1, 1998 and on the first day of every Lease
         Year (as hereinafter defined) thereafter during the term hereof, the
         Initial Base Rent (without deduction for rent abatement, if any) shall
         be increased to an amount equal to one hundred three percent (103%) of
         the amount of the Initial Base Rent which was in effect during the
         Lease Year immediately preceding the Lease Year for which the
         adjustment is being made, payable by Tenant in equal monthly
         installments in accordance with Article 3 of the Lease.

         (c) For the purpose of calculating the adjustment to the Initial Base
         Rent under this Third Amendment to Lease, the "Lease Year" shall be
         defined to mean a period of twelve (12) calendar months and the first
         Lease Year shall commence on February 1, 1997 and each succeeding Lease
         Year shall commence on the anniversary date of the beginning of the
         first Lease Year.

3.       Special Stipulation 48 of the Lease is hereby deleted in its entirety
         effective February 1, 1997. Special Stipulations 47, 51, and 53 are
         hereby deleted in their entirety.

4.       Landlord will provide Tenant with a construction allowance
         ("Construction Allowance") equal to the lesser of (a) the actual amount
         expended by Tenant in remodeling and renovating the Demised Premises or
         (b) $124,839.00 as an allowance toward construction of Tenant
         Improvements in the Demised Premises. Upon request to the Landlord, the
         Tenant Improvements performed in space leased by the Tenant at 200, 205
         and 209 Perry Parkway in Avenel Business Park shall qualify for the
         Construction Allowance. The Construction Allowance shall be payable
         after February 1, 1997 within thirty (30) days after request of Tenant
         and completion of all of the requirements specified below. Tenant
         Improvements shall include architectural/engineering fees, permit and
         inspection fees, and construction costs for alterations to or
         additional improvements of the partitions, doors, ceilings, finishes,
         mechanical equipment, electrical system, sprinkler system or other such
         permanent improvements to the Demised Premises. Prior to commencement
         of Tenant Improvements, Tenant shall submit plans and specifications
         for the Tenant Improvements for the Landlord's



<PAGE>



         review and approval, in accordance with Articles 8 and 9 of the Lease.
         The Tenant Improvements shall be performed in accordance with the
         following requirements:

         A. The Tenant shall provide lien waivers and copies of paid invoices
         from all contractors, subcontractors and suppliers of materials for all
         Tenant Improvements. Such invoices shall total or exceed the amount the
         Construction Allowance requested.

         B. Tenant shall provide its own contractors to perform all of the
         Tenant Improvements except that Tenant shall utilize the Landlord's
         roofing contractor for all roofing work or work involving penetrations
         of the roof membranae.

         C. The contractors, subcontractors or laborers employed in connection
         with such work shall comply with any applicable law and reasonable
         uniform work rules and regulations established by Landlord from time to
         time for all tenant improvements.

         D. Tenant, or its contractors and their subcontractors, shall provide
         such insurance, bonding, or indemnification as Landlord may reasonably
         require for its protection from negligence or malfeasance on the part
         of such contractors and subcontractors.

         E. In Landlord's reasonable judgement such work of the contractors or
         subcontractors will not result in delays, stoppages or other action or
         the threat thereof which may interfere with or delay the completion of
         other work in the Building.

         F. Landlord shall have the right to inspect the Tenant's work on a
         regular basis.

         G. Tenant shall be responsible for obtaining any permits, certificates,
         or approvals from any state, federal or local government necessary to
         enable Tenant to occupy the Demised Premiss and construct the Tenant
         Improvements. All costs incurred in connection with obtaining such
         permits, certificates, or approvals shall be the sole responsibility of
         Tenant.

         H. As provided for in section 9 of the Lease, Tenant shall save
         Landlord harmless from and against all expenses, liens, claims or
         damages to either property or person which may or might arises by
         reason of making the Tenant Improvements.

         I. If after complying with the terms of this Paragraph 4, the
         Construction Allowance is not paid in accordance with the terms of this
         Paragraph 4, then Tenant shall be entitled, notwithstanding anything in
         the Lease to the contrary to offset the rent by an amount equal to the
         Construction Allowance.

5.       A. Tenant represents that the list attached hereto as Exhibit A is a
         complete and accurate list of chemicals and hazardous materials,
         including approximate quantities, to be used and stored in or about the
         Demised Premises. The amounts of chemicals and hazardous materials will
         be limited to quantities necessary for the Tenant's day-to-day
         operations. Landlord is relying on the list in Exhibit F in not
         requiring Gradual Pollution and/or Contamination Liability Insurance.
         If Tenant's operations change and additional chemicals materially more
         hazardous and/or quantities significantly larger than those stipulated
         in Exhibit F are required for Tenant's operation, Tenant shall notify
         Landlord within five business days and Landlord reserves that right to
         require Tenant to obtain and maintain Gradual Pollution and/or
         Contamination Liability Insurance if in Landlord's reasonable opinion
         such change in the nature or quantity of materials being stored
         materially increases the risk of contamination. The Tenant will, upon
         written request by the Landlord, provide the Landlord with an updated
         list of chemicals and hazardous materials with quantities located
         within the Demised

         B. Prior to February 1, 1997, and within ninety (90) days after the
         expiration or earlier termination of the Lease, Landlord may engage its
         environmental consultant, Environmental Management Group or another
         environmental consultant satisfactory to Landlord to perform a Phase I
         environmental assessment of the Demised Premises and any surrounding
         areas of the Property designated by Landlord or the Environmental
         Consultant. The cost of the above described Phase I assessments shall
         be paid by Landlord unless the assessment indicates that



<PAGE>



         Tenant is not in substantial compliance with the applicable statues,
         ordinances, and regulations governing Tenant's use, storage, and
         disposal of chemicals and hazardous materials in which event Tenant
         shall reimburse Landlord as additional rent for the cost of the
         assessment. Tenant shall defend, indemnify, and hold Landlord and
         Landlord's agents, officers, directors, employees, and contractors
         harmless against and from any and all injuries, costs, expenses,
         liabilities, losses, damages, injunctions, suits, actions, fines,
         penalties, and demands of any kind or nature (including reasonable
         attorney fees) occasioned by or arising out of or relating to any
         environmental pollution, damage, condition or problem, including
         without limitation, the presence of any hazardous substances, asbestos
         or other toxic waste as defined in any federal, state, or municipal
         governmental or quasi-governmental laws, rules, regulations, or
         ordinances in effect on the Lease Date that are existing in the Demised
         Premises and caused by the acts, omissions or negligence of Tenant, its
         agents, or employees and not caused by Landlord's acts or omissions.

         C. Landlord shall have the right, at its sole cost and not as an
         operating expense, on one (1) occasion during each Lease Year to have
         Landlord's environmental consultant inspect the Tenant's records and
         procedures regarding the Tenant's storage, use, and disposal of
         chemicals and hazardous materials within the Demised Premises. In the
         event that the Landlord's environmental consultant finds that the
         Tenant is not in substantial compliance with any applicable law,
         regulation, or codes regarding the storage, use, or disposal of
         chemicals or hazardous materials, such non compliance shall constitute
         a non-monetary default under Article 16 of the Lease.

6.       Tenant shall have the option to renew the term of the Lease for one (1)
         additional period of five (5) years (the "Option Term") following the
         expiration of the initial lease term provided for in paragraph 1 of
         this Third Amendment, provided that the Lease is in full force and
         effect, the Tenant shall be in possession and occupying the Demised
         Premises, and Tenant shall not be in default in the performance or
         observance of any of the terms, conditions, provisions and/or covenants
         of the Lease. All such rights of a renewal shall be exercised by
         delivery to Landlord of written notice of Tenant's intention to renew
         the term at least nine (9) months but not more than fifteen (15) months
         prior to the expiration of the then applicable term of the lease. The
         Option Term shall be on the same terms, covenants and conditions as the
         original lease except Initial Base Rent for the Option Term shall be
         100% of the then Prevailing Market Rent of comparable space within the
         Gaithersburg market area, including current operating costs and
         concessions, which rent shall be established as follows:

         (a) Within fifteen (15) business days after receipt of Tenant's notice
         exercising its option to extend the term of this Lease, Landlord shall
         notify Tenant of Landlord's estimate of Prevailing Market Rent. If
         Tenant disagrees with Landlord's estimate of Prevailing Market Rent,
         Tenant shall notify Landlord that it has elected to submit the
         determination of Prevailing Market Rent to Arbitration, in which event
         the provisions of subparagraph (b) of this Article shall govern the
         selection of arbitrators and the establishment of the Prevailing Market
         Rent payable for the year of the then applicable Option Term; provided,
         however, that if Tenant does not elect to submit the determination of
         Prevailing Market Rent to Arbitration during such fifteen (15) day
         period, then the Landlord's estimate of Prevailing Market Rent shall be
         deemed to be agreed to by Tenant, and shall be the Initial Base Rent
         payable by Tenant to Landlord during the first year of the then
         applicable Option Term.

         (b) (i) Definition: As used herein, the term "Prevailing Market Rent"
         means the most probable rent (as determined pursuant to the appraisal
         procedure hereinafter set forth) at which the Demised Premises (and any
         Additional Premises) would be leased in a comparable and open market,
         under all conditions requisite to a fair Lease, the Landlord and Tenant
         each acting prudently, knowledgeable, and assuming the rent is not
         affected by undue stimulus. Implicit in this definition is the
         consummation of the Lease beginning on the commencement date of the
         Option Term under conditions whereby:

         1. Landlord and Tenant are typically motivated (i.e., neither party is
         compelled to enter into a lease and both parties are willing to enter
         into a lease).


<PAGE>


         2. Both parties are well informed or well advised, and each acting in
         what it considers its own best interest.

         3. A reasonable time is allowed for exposure in the open market.

         4. The Prevailing Market Rent shall be computed as an amount equal to
         the then prevailing market rental rate of the Demised Premises, as if
         vacant with building standard improvements, and taking into account the
         annual adjustments of Initial Base Rent, Tenant's obligation to pay
         Tenant's pro-rata share of Annual Operating Expenses and all existing
         market factors.

         5. All of the terms, covenants and conditions of the Lease (except
         terms respecting the amount of Initial Base Rent) remain in effect
         throughout the applicable Option Term.

         (ii) In the event of a dispute as to determination of Prevailing Market
         Rent referred to in this Article, or a dispute of any of the provisions
         of this Lease, such dispute shall be in accordance with the following:

         (a) If Landlord and Tenant fail to agree upon the Prevailing Market
         Rent as referred to in this Article, within the time periods provided
         for herein, then Landlord and Tenant each shall give notice to the
         other setting both the name and address of a licensed real estate
         broker or appraiser (hereinafter "appraiser") who shall be a M.A.I.
         Real Estate professional with substantial experience in commercial real
         estate appraisal designated by it to make the determinations hereafter
         required. Each appraiser shall be instructed to calculate the
         Prevailing Market Rent as provided in each of the foregoing sections
         which is the subject of the dispute and is in accordance with the
         criteria referenced therein. If either party shall fail to give notice
         of such designations within ten (10) days after failing to agree
         between themselves, then the appraisal made by the appraiser so
         designated shall be the Appraisal Prevailing Market Rent. If two
         appraisers have been designated, such two appraisers shall consult with
         each other and, within thirty (30) days thereafter, issue their
         determinations of Appraisal Prevailing Market Rent in writing, and give
         notice thereof to each other and to Landlord and Tenant. If such two
         appraisers shall concur as to the determination of the prevailing
         Market Rent and submit their decision in writing to Landlord and
         Tenant, such concurrence shall be final and binding upon Landlord and
         Tenant. If the two determinations of Prevailing Market Rent shall be
         within five percent (5%) (measured from the higher appraisal) of each
         other, the Prevailing Market Rent shall be deemed to be the average of
         the two appraisers' determinations. If such two appraisers'
         determinations shall not so concur or coincide, then such two
         appraisers shall immediately (i) designate a third appraiser, (ii)
         prepare detailed written appraisals, and (iii) submit copies of such
         appraisal to Landlord, Tenant and such third arbitrator. If the two
         appraisers shall fail to agree upon the designation of such third
         appraiser within eight (8) days of the date on which the last
         determination was rendered, then either party may apply to the American
         Arbitration Association or any successor thereto having jurisdiction,
         for the designation of such appraiser. All arbitrators shall be
         licensed real estate appraisers who shall have had at least fifteen
         (15) years continuous experience in the business of appraising real
         estate in the Montgomery County area. The third appraiser shall conduct
         such hearings and investigations as he may deem appropriate and shall,
         within twenty (20) days after the date of designation of the third
         appraiser, choose the determination of the two appraisers originally
         selected by the parties which is the nearest to the determination such
         third appraiser would have made acting alone and applying the standards
         set forth therefor in this Lease, and that choice by the third
         appraiser shall be binding upon Landlord and Tenant. Each party shall
         pay its own counsel fees and expenses, if any, in connection with any
         arbitration under this Article, including the expenses and fees of any
         appraiser selected by it in accordance with the provisions of this
         Article, and the parties shall share equally all other expenses and
         fees of any such arbitration, including the expenses of the third
         appraiser. The determination rendered in accordance with the provisions
         of this Article shall be final and binding in fixing the Prevailing
         Market Rent. Notwithstanding the foregoing, in no event shall the Basic
         Rent for the First Lease Year of the Option Term be less than the then
         Initial Base Rent of the last Lease Year of the initial lease term of
         this Third Amendment escalated by three percent.



<PAGE>




7.       Landlord will use reasonable efforts to obtain a non-disturbance
         agreement for Tenant's benefit from the holder of the mortgage lien on
         the Property (the "Lender"). The non-disturbance agreement shall be on
         the Lender's approved form, and Tenant shall pay to Landlord, as
         additional rent, all fees, costs and expenses charged to Landlord by
         the Lender in connection with the Lender's review of this Lease
         including, without limitation, the Lender's legal fees. This Lease
         shall not be subordinate to any future mortgage, deed of trust or other
         lien on the Property unless the party secured by any such instrument
         enters into a non-disturbance agreement with Tenant on a form
         acceptable to such future Lender.

8.       Except as modified hereby, the Lease shall remain in full force and
         effect in accordance with its terms, and is hereby ratified, confirmed
         and approved in all respects.

WITNESS the following signatures and seals.


ATTEST:                             LANDLORD:SAUL HOLDINGS LIMITED PARTNERSHIP
                                    By: SAUL CENTERS, INC., ITS GENERAL PARTNER


       [SIG]                        By:/s/ PHILIP D. CARACI
- ---------------------------            ------------------------------------
(SEAL)     Secretary                   Philip D. Caraci, President


ATTEST:                             TENANT:  ONCOR, INC.

        [SIG]                       By:        [SIG]
- ---------------------------            ------------------------------------
(SEAL)     Secretary



<PAGE>
                      FIRST AMENDMENT TO THE LEASE BETWEEN

                        SAUL HOLDINGS LIMITED PARTNERSHIP

                                 AND ONCOR, INC.
                                200 PERRY PARKWAY

         This FIRST AMENDMENT TO LEASE is made and entered into this 15th day of
October, 1996 by and between SAUL HOLDINGS LIMITED PARTNERSHIP (hereinafter
referred to as "Landlord") and ONCOR, INC. a Maryland Corporation (hereinafter
referred to as "Tenant"),

         WHEREAS, Landlord and Tenant have entered into that certain Lease dated
December 14, 1995 (the "Lease") for approximately 4,256 square feet in 205 Perry
Parkway, Avenel Business Park, Gaithersburg, Maryland 20877; and

         WHEREAS, the parties hereto desire to enter into this First Amendment
to Lease for the purposes hereinafter set out.

         NOW, THEREFORE, in consideration of the premises and other good and
valuable consideration, the receipt and sufficiency of which is hereby
acknowledged, the parties hereto agree as follows:

1.       Article 2 of the Lease captioned "Term" is hereby modified to extend
         the term of the Lease for sixty-four (64) months, commencing on
         December 1. 1998 and expiring on March 31, 2004.

2.       (a) Article 3 of the Lease captioned "Rent" is hereby modified as of
         February 1, 1997 to change the annual Initial Base Rent payable under
         the Lease from and after February 1, 1997 to Fifty Three Thousand Two
         Hundred Dollars ($53,200) payable in equal monthly installments of Four
         Thousand Four Hundred Thirty Three and 34/100 Dollars ($4,433.33).

         (b) Commencing on February 1, 1998 and on the first day of every Lease
         Year (as hereinafter defined) thereafter during the term hereof, the
         Initial Base Rent (without deduction for rent abatement, if any) shall
         be increased to an amount equal to one hundred three percent (103%) of
         the amount of the Initial Base Rent which was in effect during the
         Lease Year immediately preceding the Lease Year for which the
         adjustment is being made, payable by Tenant in equal monthly
         installments in accordance with Article 3 of the Lease.

         (c) For the purpose of calculating the adjustment to the Initial Base
         Rent under this First Amendment to Lease, the "Lease Year" shall be
         defined to mean a period of twelve (12) calendar months and the first
         Lease Year shall commence on February 1, 1997 and each succeeding Lease
         Year shall commence on the anniversary date of the beginning of the
         first Lease Year.

3.       Special Stipulation 47 is hereby deleted in its entirety effective
         February 1, 1997.

4.       A. Tenant represents that the list attached hereto as Exhibit A is a
         complete and accurate list of chemicals and hazardous materials,
         including approximate quantities, to be used and stored in or about the
         Demised Premises. The amounts of chemicals and hazardous materials will
         be limited to quantities necessary for the Tenant's day-to-day
         operations. Landlord is relying on the list in Exhibit F in not
         requiring Gradual Pollution and/or Contamination Liability Insurance.
         If Tenant's operations change and additional chemicals and/or
         quantities significantly larger than those stipulated in Exhibit F are
         required for Tenant's operation, Tenant shall immediately notify
         Landlord and Landlord reserves that right to require Tenant to obtain
         and maintain Gradual Pollution and/or Contamination Liability
         Insurance. The Tenant will, upon written request by the Landlord,
         provide the Landlord with an updated list of chemicals and hazardous
         materials with quantities located within the Demised Premises.

         B. Prior to February 1, 1997, and within ninety (90) days after the
         expiration or earlier termination of the Lease, Landlord may engage its
         environmental consultant, Environmental Management Group or another
         environmental consultant satisfactory to Landlord to perform



<PAGE>


         a Phase I environmental assessment of the Demised Premises and any
         surrounding areas of the Property designated by Landlord or the
         Environmental Consultant. The cost of the above described Phase I
         assessments shall be paid by Landlord unless the assessment indicates
         that Tenant is not in substantial compliance with the applicable
         statues, ordinances, and regulations governing Tenant's use, storage,
         and disposal of chemicals and hazardous materials in which event Tenant
         shall reimburse Landlord as additional rent for the cost of the
         assessment. Tenant shall defend, indemnify, and hold Landlord and
         Landlord's agents, officers, directors, employees, and contractors
         harmless against and from any and all injuries, costs, expenses,
         liabilities, losses, damages, injunctions, suits, actions, fines,
         penalties, and demands of any kind or nature (including reasonable
         attorney fees) occasioned by or arising out of or relating to any
         environmental pollution, damage, condition or problem, including
         without limitation, the presence of any hazardous substances, asbestos
         or other toxic waste as defined in any federal, state, or municipal
         governmental or quasi-governmental laws, rules, regulations, or
         ordinances in effect on the Lease Date that are existing in the Demised
         Premises and caused by the acts, omissions or negligence of Tenant, its
         agents, or employees and not caused by Landlord's acts or omissions.

         C. Landlord shall have the right, at its sole cost and not as an
         operating expenses, on one (1) occasion during each Lease Year to have
         Landlord's environmental consultant inspect the Tenant's records and
         procedures regarding the Tenant's storage, use, and disposal of
         chemicals and hazardous materials within the Demised Premises. In the
         event that the Landlord's environmental consultant finds that the
         Tenant is not in substantial compliance with any applicable law,
         regulation, or codes regarding the storage, use, or disposal of
         chemicals or hazardous materials, such non compliance shall constitute
         a non-monetary default under Article 16 of the Lease.

5.       Tenant shall have the option to renew the term of the Lease for one (1)
         additional period of five (5) years (the "Option Term") following the
         expiration of the initial lease term provided for in paragraph 1 of
         this First Amendment, provided that the Lease is in full force and
         effect, the Tenant shall be in possession and occupying the Demised
         Premises, and Tenant shall not be in default in the performance or
         observance of any of the terms, conditions, provisions and/or covenants
         of the Lease. All such rights of a renewal shall be exercised by
         delivery to Landlord of written notice of Tenant's intention to renew
         the term at least nine (9) months but not more than fifteen (15) months
         prior to the expiration of the then applicable term of the lease. The
         Option Term shall be on the same terms, covenants and conditions as the
         original lease except Initial Base Rent for the Option Term shall be
         100% of the then Prevailing Market Rent of comparable space within the
         Gaithersburg market area, including current operating costs and
         concessions, which rent shall be established as follows:

         (a) Within fifteen (15) business days after receipt of Tenant's notice
         exercising its option to extend the term of this Lease, Landlord shall
         notify Tenant of Landlord's estimate of Prevailing Market Rent. If
         Tenant disagrees with Landlord's estimate of Prevailing Market Rent,
         Tenant shall notify Landlord that it has elected to submit the
         determination of Prevailing Market Rent to Arbitration, in which event
         the provisions of subparagraph (b) of this Article shall govern the
         selection of arbitrators and the establishment of the Prevailing Market
         Rent payable for the year of the then applicable Option Term; provided,
         however, that if Tenant does not elect to submit the determination of
         Prevailing Market Rent to Arbitration during such fifteen (15) day
         period, then the Landlord's estimate of Prevailing Market Rent shall be
         deemed to be agreed to by Tenant, and shall be the Initial Base Rent
         payable by Tenant to Landlord during the first year of the then
         applicable Option Term.

         (b) (i) Definition: As used herein, the term "Prevailing Market Rent"
         means the most probable rent (as determined pursuant to the appraisal
         procedure hereinafter set forth) at which the Demised Premises (and any
         Additional Premises) would be leased in a comparable and open market,
         under all conditions requisite to a fair Lease, the Landlord and Tenant
         each acting prudently, knowledgeable, and assuming the rent is not
         affected by undue stimulus. Implicit in this definition is the
         consummation of the Lease beginning on the commencement date of the
         Option Term under conditions whereby:


<PAGE>

1. Landlord and Tenant are typically motivated (i.e., neither party is compelled
to enter into a lease and both parties are willing to enter into a lease).

2. Both parties are well informed or well advised, and each acting in what it
considers its own best interest.

3. A reasonable time is allowed for exposure in the open market.

4. The Prevailing Market Rent shall be computed as an amount equal to the then
prevailing market rental rate of the Demised Premises, as if vacant with
building standard improvements, and taking into account the annual adjustments
of Initial Base Rent, Tenant's obligation to pay Tenant's pro-rata share of
Annual Operating Expenses and all existing market factors.

5. All of the terms, covenants and conditions of the Lease (except terms
respecting the amount of Initial Base Rent) remain in effect throughout the
applicable Option Term.

(ii) In the event of a dispute as to determination of Prevailing Market Rent
referred to in this Article, or a dispute of any of the provisions of this
Lease, such dispute shall be in accordance with the following:

(a) If Landlord and Tenant fail to agree upon the Prevailing Market Rent as
referred to in this Article, within the time periods provided for herein, then
Landlord and Tenant each shall give notice to the other setting both the name
and address of a licensed real estate broker or appraiser (hereinafter
"appraiser") who shall be a M.A.I. Real Estate professional with substantial
experience in commercial real estate appraisal designated by it to make the
determinations hereafter required. Each appraiser shall be instructed to
calculate the Prevailing Market Rent as provided in each of the foregoing
sections which is the subject of the dispute and is in accordance with the
criteria referenced therein. If either party shall fail to give notice of such
designations within ten (10) days after failing to agree between themselves,
then the appraisal made by the appraiser so designated shall be the Appraisal
Prevailing Market Rent. If two appraisers have been designated, such two
appraisers shall consult with each other and, within thirty (30) days
thereafter, issue their determinations of Appraisal Prevailing Market Rent in
writing, and give notice thereof to each other and to Landlord and Tenant. If
such two appraisers shall concur as to the determination of the prevailing
Market Rent and submit their decision in writing to Landlord and Tenant, such
concurrence shall be final and binding upon Landlord and Tenant. If the two
determinations of Prevailing Market Rent shall be within five percent (5%)
(measured from the higher appraisal) of each other, the Prevailing Market Rent
shall be deemed to be the average of the two appraisers' determinations. If such
two appraisers' determinations shall not so concur or coincide, then such two
appraisers shall immediately (i) designate a third appraiser, (ii) prepare
detailed written appraisals, and (iii) submit copies of such appraisal to
Landlord, Tenant and such third arbitrator. If the two appraisers shall fail to
agree upon the designation of such third appraiser within eight (8) days of the
date on which the last determination was rendered, then either party may apply
to the American Arbitration Association or any successor thereto having
jurisdiction, for the designation of such appraiser. All arbitrators shall be
licensed real estate appraisers who shall have had at least fifteen (15) years
continuous experience in the business of appraising real estate in the
Montgomery County area. The third appraiser shall conduct such hearings and
investigations as he may deem appropriate and shall, within twenty (20) days
after the date of designation of the third appraiser, choose the determination
of the two appraisers originally selected by the parties which is the nearest to
the determination such third appraiser would have made acting alone and applying
the standards set forth therefor in this Lease, and that choice by the third
appraiser shall be binding upon Landlord and Tenant. Each party shall pay its
own counsel fees and expenses, if any, in connection with any arbitration under
this Article, including the expenses and fees of any appraiser selected by it in
accordance with the provisions of this Article, and the parties shall share
equally all other expenses and fees of any such arbitration, including the
expenses of the third appraiser. The determination rendered in accordance with
the provisions of this Article shall be final and binding in fixing the
Prevailing Market Rent. Notwithstanding the foregoing, in no event shall the
Basic Rent for the First Lease Year of



<PAGE>




         the Option Term be less than the then Initial Base Rent of the last
         Lease Year of the initial lease term of this First Amendment escalated
         by three percent.

6.       Landlord will use reasonable efforts to obtain a non-disturbance
         agreement for Tenant's benefit from the holder of the mortgage lien on
         the Property (the "Lender"). The non-disturbance agreement shall be on
         the Lender's approved form, and Tenant shall pay to Landlord, as
         additional rent, all fees, costs and expenses charged to Landlord by
         the Lender in connection with the Lender's review of this Lease
         including, without limitation, the Lender's legal fees. This Lease
         shall not be subordinate to any future mortgage, deed of trust or other
         lien on the Property unless the party secured by any such instrument
         enters into a non-disturbance agreement with Tenant on a form
         acceptable to such future Lender.

7.       Except as modified hereby, the Lease shall remain in full force and
         effect in accordance with its terms, and is hereby ratified, confirmed
         and approved in all respects.

WITNESS the following signatures and seals.



ATTEST:                             LANDLORD:SAUL HOLDINGS LIMITED PARTNERSHIP
                                    By: SAUL CENTERS, INC., ITS GENERAL PARTNER


       [SIG]                        By:/s/ PHILIP D. CARACI
- ---------------------------            ------------------------------------
(SEAL)     Secretary                   Philip D. Caraci, President


ATTEST:                             TENANT:  ONCOR, INC.

        [SIG]                       By:    [SIG]
- ---------------------------            ------------------------------------
(SEAL)     Secretary

<PAGE>
             FOURTH AMENDMENT TO THE LEASE BETWEEN
             SAUL HOLDINGS LIMITED PARTNERSHIP AND
                          ONCOR, INC.
                       209 PERRY PARKWAY

         This FOURTH AMENDMENT TO LEASE is made and entered into this ______
day of _________, 1997, by and between SAUL HOLDINGS LIMITED PARTNERSHIP
(hereinafter referred to as "Landlord"), successor in interest to Avenel
Associates Limited Partnership, and ONCOR, INC., a Maryland Corporation
(hereinafter referred to as "Tenant").

         WHEREAS, Landlord's predecessor and Tenant entered into that certain
Lease dated March 22, 1990, as amended by an Amendment to Lease dated February
25, 1991, a Second Amendment to Lease dated June 21, 1991, and a Third
Amendment to Lease dated October 15, 1996 (the "Lease"), for approximately
25,941 square feet in 209 Perry Parkway, Avenel Business Park, Gaithersburg,
Maryland 20877 ("Demised Premises"); and 

         WHEREAS, the parties hereto desire to enter into this Fourth
Amendment to Lease for the purposes hereinafter set out:

         NOW, THEREFORE, in consideration of the premises and other good and
valuable consideration, the receipt and sufficiency of which is hereby
acknowledged, the parties hereto agree as follows:

1.       All terms used herein and defined in the Lease shall have the same
meaning as in the Lease unless otherwise defined herein.

2.       Commencing on the Effective Date (as hereinafter defined), and
subject to the following sentence herein, the square footage of the Demised
Premises shall be increased by approximately 6,236 square feet of space, shown
cross-hatched in red on the site plan attached hereto as Exhibit A
("Additional Space"), for a total square footage of approximately 32,177. 
Within ten (10) days of Landlord's receipt of Tenant's final plans and
specifications for the improvements to the Additional Space, as approved by
Landlord, Landlord's architect shall measure the space and Landlord shall
notify Tenant in writing of the actual square footage of the Additional Space. 
All Rent and additional charges payable under the Lease, and as modified
herein, shall be adjusted accordingly.  Upon the Effective Date, the Demised
Premises, as that term is defined and used in the Lease shall be deemed to
include the Additional Space.

3.       Commencing May 1, 1997, Tenant's Base Rent shall be increased by an
additional $13.00 per square foot of additional Space, and Article 3 of the
Lease captioned Rent is hereby modified to change the Annual Base Rent payable
under the Lease to Four Hundred Five Thousand Three Hundred Thirty-two and
04/100 Dollars ($405,332.04), payable in equal monthly installments of
Thirty-three Thousand Seven Hundred Seventy-seven and 67/100 Dollars
($33,777.67). The increase in the Base Rent payable to Landlord herein is
subject to further modification upon verification of the square footage of the
Additional Space as provided in Paragraph 1 hereof.

4.       Tenant is accepting the Additional Space in "as is" condition. 
Tenant agrees that it has inspected the Additional Space and that no
representations have been made by Landlord as to the condition thereof except
as are expressly set forth in this Amendment.

5.       (a) Landlord will provide Tenant with a construction allowance
("Construction Allowance") in an amount equal to the lesser of (i) the actual
amount expended by Tenant for the Tenant Improvements (as hereinafter defined)
to the Additional Space; or (ii) Eight and 50/100 Dollars ($8.50) per square
foot of Additional Space as an allowance toward construction of Tenant
Improvements.  The Construction Allowance shall be utilized by Tenant for
architectural/engineering fees, permit and inspection fees and construction
costs for alterations to or additional improvements of the partitions, doors,
ceilings, fixtures, mechanical equipment, electrical system, sprinkler system
or other such permanent improvements to the Additional Space ("Tenant
Improvements") and shall be payable within thirty (30) days after Landlord's
receipt of written request of Tenant and Tenant's full compliance with all of
the requirements specified below.  Within thirty (30) days of the Effective
Date, Tenant shall submit plans and specifications for the Tenant Improvements
to the Additional Space for Landlord's review and approval, in accordance with
Articles 8 and 9 of the Lease.  Tenant shall observe and perform all of
Tenant's obligations under the Lease, as amended herein, from and after the
date the Additional Space is delivered to Tenant in the same manner as though
the Additional Space were deemed to be the Demised Premises as of the delivery
date.  Landlord shall have no liability whatsoever for loss or damage to
Tenant Improvements or fixtures, equipment or other property of Tenant or
Tenant's contractors.  It is expressly understood that Tenant shall, to the
fullest extent possible, perform or cause to be performed the Tenant
Improvements without causing any interference whatsoever with the activities
and business of adjoining tenants and the use of the common areas by tenants
and their customers, agents, invitees and licensees.  The Tenant Improvements
shall be performed in accordance with the following requirements:

         A.   The Tenant shall provide lien waivers and copies of paid
invoices from all contractors, subcontractors and suppliers of materials for
all Tenant Improvements.  Such invoices shall total or exceed the amount of
the Construction Allowance requested.

         B.   Tenant shall provide its own contractors to perform all the
Tenant Improvements except that Tenant shall utilize the Landlord's roofing
contractor for all roofing work or work involving penetrations of the roof
membrane.

         C.   The contractors, subcontractors or laborers employed in
connection with such work shall comply with any applicable law and reasonable
uniform work rules and regulations established by Landlord from time to time
for all tenant improvements.

         D.   Tenant, or its contractors and their subcontractors, shall
provide such insurance, bonding, or indemnification as Landlord may reasonably
require for its protection from negligence or malfeasance on the part of such
contractors and subcontractors.

         E.   In Landlord's reasonable judgment, such work of contractors or
subcontractors will not result in delays, stoppages or other action or the
threat thereof which may interfere with or delay the completion of other work
in the Building.

         F.   Landlord shall have the right to inspect the Tenant's work on a
regular basis.

         G.   Tenant shall be responsible for obtaining any permits,
certificates, or approvals from any state, federal or local government
necessary to enable Tenant to occupy the Additional Space and construct the
Tenant Improvements. All costs incurred in connection with obtaining such
permits, certificates or approvals shall be the sole responsibility of Tenant.

         H.   As provided in Article 9 of the Lease, Tenant shall save
Landlord harmless from and against all expenses, liens, claims or damages to
either property or person which may or might arise by reason of making the
Tenant Improvements.

(b)     Tenant shall use good faith efforts to complete the Tenant
Improvements on or before May 31, 1997.

6.       Provided Tenant is not in default of the terms and  conditions of the
Lease either on the date of the Option Notice (as hereinafter defined) or on
the Option Effective Date (as hereinafter defined), then Tenant shall have the
right, with written notice to Landlord given no later than June 30, 1997
("Option Notice"), to lease additional space containing approximately 10,005
square feet as shown cross hatched in blue on Exhibit A ("Option Space").

(a)      If Tenant exercises its option to lease the Option Space in
accordance with the provisions of this paragraph 6, then Tenant shall execute
and deliver to Landlord a lease amendment within ten (10) business days after
Landlord submits the same to Tenant, which shall include the following terms
and conditions:

     (i)   Effective forty (40) days after the date of the Option Notice 
("Option Effective Date"), the square footage of the Demised Premises shall
be deemed increased by the square footage of the Option Space.

     (ii)  As of the Option Effective Date, Tenant's Annual Base Rent shall 
           be increased by $13.00 per square foot of Option Space.

     (iii)  Tenant is accepting the Option Space in "as is" condition.  
            Tenant agrees that it has inspected the Option Space and that no 
            representations have been made by Landlord as to the condition 
            thereof except as are expressly set forth in this Amendment.

     (iv)  Landlord will provide Tenant with a construction allowance
            ("Construction Allowance") in an amount equal to the lesser of (a) 
            the actual amount expended by Tenant for the Tenant Improvements   
            (as hereinafter defined) to the Option Space; or (b) Eight and     
            50/100 Dollars ($8.50) per square foot of Option Space as an       
            allowance toward construction of Tenant Improvements.  The 
            Construction Allowance shall be utilized by Tenant for
            architectural/engineering fees, permit and inspection fees and 
            construction costs for alterations to or additional improvements 
            of the partitions, doors, ceilings, fixtures, mechanical 
            equipment, electrical system, sprinkler system or other such       
            permanent improvements to the Option Space ("Tenant
            Improvements") and shall be payable within thirty (30) days after  
            Landlord's receipt of written request of Tenant and Tenant's full  
            compliance with all of the requirements specified in Paragraph     
            5(a)A-H.  Prior to commencement of the Tenant Improvements to the  
            Option Space, Tenant shall submit plans and specifications for the 
            Tenant Improvements to the Option Space for Landlord's review and  
            approval, in accordance with Articles 8 and 9 of the Lease.        
            Tenant shall observe and perform all of Tenant's obligations under 
            the Lease, as amended herein, from and after the date the Option   
            Space is delivered to Tenant in the same manner as though the      
            Option Space were deemed to be the Demised Premises as of the      
            delivery date. Landlord shall have no liability whatsoever for     
            loss or damage to Tenant Improvements or fixtures, equipment or
            other property of Tenant or Tenant's contractors.  It is expressly 
            understood that Tenant shall, to the fullest extent possible,      
            perform or cause to be performed the Tenant Improvements without   
            causing any interference whatsoever with the activities and        
            business of adjoining tenants and the use of the common areas by   
            tenants and their customers, agents, invitees and licensees. The   
            Tenant Improvements shall be performed in accordance with the      
            requirements set forth in Paragraph 5(a)A-H.

(b)      Provided (i) Tenant is not then in default (beyond any applicable
cureperiod) in any of its obligations under this Lease, and (ii) Landlord
desiresto lease the Option Space (hereinafter defined) to any party, Landlord
agrees that, during the initial term of the Lease, Tenant shall have the right
of first offer to enter into a lease of the Option Space (the "Option Space")
in accordance with the terms and conditions set forth in this paragraph (b),
as follows:

         (i)  After receipt of a written proposal to lease the Option Space 
from a prospective tenant or its agent ("Prospective Tenant") and prior to
entering into a lease with that Prospective Tenant for the Option
Space, Landlord shall send to Tenant an offer notice of the availability of
such space (the "OFFER NOTICE").

         (ii) Within ten (10) business days after Tenant's receipt of the 
Offer Notice, Tenant shall notify Landlord that Tenant either (1) agrees
to lease the Option Space, or (2) does not desire to lease the Option
Space and the Landlord shall have the right to lease the Option Space to
the Prospective Tenant.  A failure by Tenant to timely elect the option
described in clauses (1) or (2) above shall be deemed a to be a waiver
by Tenant of any further right to lease the Option Space under this paragraph.
If Tenant elects the option described in clause (2) above, the Tenant
shall have additional first rights of offer provided that the Option Space
is not leased to the Prospective Tenant or the Option Space becomes
available during the initial term of the Lease and subject to the initial
or renewal occupancy by the Prospective Tenant.

       (iii)  If Tenant exercises its option to lease the Option Space
              under this paragraph, then Tenant shall execute a lease          
              amendment embodying the terms set forth in the Offer             
              Notice, within ten (10) business days after Landlord             
              submits any such lease amendment to Tenant which shall           
              provide that the following terms and conditions                  
              shall apply to the Option Space:

              (a)  The Premises shall be modified effective as of the date
                   falling 40 days after the date of the Offer Notice (the
                   "Option Effective Date") to increase the size of the   
                   Demised Premises by approximately 10,005 rentable square
                   feet size.

              (b)  As of the Option Effective Date, the initial Base Rent for
                   the Option Space shall be the Initial Base Rent per square
                   foot set forth below for the year in which Tenant exercises
                   its option under this paragraph and such Initial Base Rent
                   shall be increased on the first day of each succeeding
                Lease Year to the amounts set forth below.

                   OPTION EXERCISE DATE     RENT PER SQUARE FOOT

                   Before February 1, 1998       $13.00
                   Before February 1, 1999       $13.50
                   Before February 1, 2000       $14.00
                   Before February 1, 2001       $14.50
                   Before February 1, 2002       $15.00
                   Before February 1, 2003       $15.50
                   Before February 1, 2004       $16.00

              (c)  The Annual Operating Costs shall be modified as of the
                   Option Effective Date to increase Tenant's Pro-Rata Share
                   of Annual Operating Cost to reflect the increased size of
                   the Demised Premises.

              (d)  Tenant agrees to accept the Option Space "as is" in its
                   then existing condition and Landlord shall have no
                   construction obligations with respect thereto. 
                   However, the Landlord will provide Tenant with a
                   construction  allowance ("Option Space Construction
                   Allowance") equal to the lesser of (a) the actual amount
                   expended by Tenant in remodeling and renovating the
                   Option Space or (b) an amount equal to $774.19 multiplied
                   by the number of full months remaining on the initial
                   term of the Lease from the Option Effective Date.  The
                   Option Space Construction Allowance shall be used for the
                   construction of Tenant Improvements in the Option Space.
                   The Construction Allowance shall be payable within thirty
                   (30) days after request of Tenant and completion of all
                   of the requirements specified below.  Tenant Improvements
                   shall include architectural/engineering fees, permit and
                   inspection fees, and construction costs for alterations
                   to or additional improvements of the partitions, doors,
                   ceilings, finishes, mechanical equipment, electrical 
                   system, sprinkler system or other  such permanent
                   improvements to the Option Space.  Prior to commencement
                   of Tenant Improvements, Tenant shall submit plans and
                   specifications for the Tenant Improvements for the
                   Landlord's review and approval, in accordance with 
                   Articles 8 and 9 of the Lease.  The provisions,
                   requirements and conditions of subparagraphs (5)(a)A-H
                   above will apply to the Option Space Construction 
                   Allowance.

         (iv) Landlord may, at its option, in lieu of a narrative description
              of the terms to be described in the Offer Notice, submit to 
              Tenant a lease amendment document setting forth the terms of
              the proposed lease amendment for the Option Space in which event
              Tenant's exercise of its option to lease the Option Space shall
              be made by Tenant's execution of such lease amendment document   
              and its return to Landlord within the applicable time periods
              set forth above. If Landlord does not submit a lease amendment
              document to Tenant at the time the Offer Notice is given, and
              Tenant exercises its option to lease the Option Space under such
              terms, then Tenant shall execute a lease amendment embodying
              terms set forth in the Offer Notice within ten (10) days after
              Landlord submits any such lease amendment to Tenant, as provided
              above.

         (v)  Tenant shall have no further right to lease the Option space
              under this paragraph after Landlord enters into a lease of the
              Option Space with the Prospective Tenant in accordance with this
              paragraph unless the Option Space is vacated by the Prospective
              Tenant during the initial term of the Lease.

         (vi) Tenant's right to lease the Option Space shall be conditioned
              upon Tenant's full and complete compliance with all of the terms
              and conditions of the Lease prior to the date of any Offer
              Notice, and Tenant's option to lease the Option Space shall 
              terminate when the initial term of the Lease expires or
              terminates.

(c)      Time shall be of the essence with respect to Tenant's right to lease
the Option Space and with respect to Tenant's fight of first offer under this
Paragraph 6.

7.       Tenant's proportionate share of all taxes and assessments, insurance
and operating costs shall be adjusted in accordance with the provisions of
this Amendment.

8.       Article 7 of the Third Amendment to Lease is hereby deleted in its
entirety.

9.       The Effective Date is the date of this Amendment.

10.      Except as modified hereby, the Lease shall remain in full force and
effect in accordance with its terms, and is hereby ratified, confirmed and
approved in all respects.

11.      Any agreements, obligation or liability, made, entered into or
incurred by or on behalf of Landlord binds only its property and no
shareholder, trustee, officer, employee, director, partner or agent of the
Landlord assumes or shall be held to any liability therefor.

12.      The provisions of this Amendment shall be binding upon the parties
hereto, their successors, and to the extent permitted under the Lease, their
assigns.

13.      The submission of this Amendment for examination does not constitute
an agreement, an option or an offer, and this Amendment becomes effective only
upon execution and delivery thereof by Landlord.  Captions and headings, if
any, are for convenience and reference only and shall not in any way define,
limit or describe the scope or content of any provision of this Amendment.
Whenever in this Amendment (i) any printed portion, or any part thereof, has
been stricken out, or (ii) any portion of the Lease (as the same may have been
previously amended) or any part thereof, has been modified or stricken out,
then, in either of such events, whether or not any replacement provision has
been added, this Amendment and the Lease shall hereafter be read and construed
as if from the text of the material so stricken out which would be
inconsistent in any way with the construction or interpretation which would be
appropriate if such material had never been contained herein or in the Lease.

         WITNESS the following signatures and seals.

ATTEST:                  LANDLORD:
                         SAUL HOLDINGS LIMITED PARTNERSHIP
                         BY:    SAUL CENTERS, INC.,
                                          ITS GENERAL PARTNER

                         By:
- ----------------------       -----------------------------
(SEAL)  Secretary            Philip D. Caraci, President


ATTEST:                  TENANT:
                         ONCOR, INC.


                         By:         [sig]
- ----------------------       -----------------------------
(SEAL)  Secretary
                         Name:
                              ----------------------------

                         Title:
                               ----------------------------     


<PAGE>
                     SECRETARY'S CERTIFICATE

I, JOHN COKER, Secretary of Oncor, Inc., a Maryland corporation, do hereby
certify (i) that the foregoing and annexed Lease was executed and delivered
pursuant to, and in strict conformity with the provisions of resolutions of
the Board of Directors of said Corporation validly adopted at a regularly
called meeting of said Board of Directors, and that a quorum was present at
said meeting (or validly adopted by unanimous written consent of said Board of
Directors in lieu of a meeting), in conformity with the laws of the state of
incorporation of said Corporation; and (ii) that the following is a true,
correct and complete reproduction of such resolutions:

       RESOLVED: That CECIL KOST, President and JOHN COKER, Vice President
of the Corporation, shall be and is hereby authorized and empowered, for and
on behalf of the Corporation, to execute, acknowledge and deliver the
foregoing and annexed Fourth Amendment to Lease between Saul Holdings Limited
Partnership, as Landlord, and Oncor, Inc., as Tenant, for those certain
Premises located in the Building at 209 Perry Parkway, Avenel Business Park,
Gaithersburg, Maryland, at an annual Base Rental of approximately Four Hundred
Five Thousand Three Hundred Thirty-two and 04/100 Dollars ($405,332.04), as
well as any and all related documents, in order to expeditiously provide for
the leasing of such Premises, and in so doing, to make any and all related
changes therein or modifications thereof as he, in his sole discretion, acting
for and on behalf of the Corporation, shall deem necessary or advisable, and
all of the officers of the Corporation are hereby authorized, directed and
empowered to do any and all acts or things as shall be necessary or advisable
in order to effectuate the foregoing resolution.

[sig]
- -----------------------------------------

Printed Name:                                 , Secretary
             ---------------------------------

Date
     --------------------------------------------

(Corporate Seal)







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