INSURED MUNICIPALS INCOME TR & INVS QUA TAX EX TR MUT SER 46, 497J, 1998-12-30

INSURED MUNICIPALS INCOME TR & INVS QUA TAX EX TR MUT SER 46
497J, 1998-12-30

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                                December 30, 1998
                                    
                                    
                                    
Securities and Exchange Commission
450 Fifth Street, N.W.
Washington, D.C.  20549-1004

Attn:  Filing Desk - Stop 1-4
     
     Re:  Insured Municipals Income Trust and Investors' Quality Tax-Exempt
          Trust, Multi-Series 46
          File No. 33-10686   CIK #0000807436

Ladies/Gentlemen:
     
         In accordance with the provisions of Rule 497(j) of Regulation C under
the Securities Act of 1933 (the "Securities Act") this letter serves to certify
that the most recent amendment to the subject Registration Statement on Form S-6
for the above captioned Trust does not differ from that which would have been
filed pursuant to Rule 497(b) of the Securities Act. The most recent amendment
to the Registration Statement was filed electronically with the commission on
December 24, 1998.

                                    Very truly yours,

                                    Van Kampen Funds Inc.