GENSIA SICOR INC
S-3MEF, 1997-10-06
PHARMACEUTICAL PREPARATIONS
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<PAGE>
 
    As filed with the Securities and Exchange Commission on October 6, 1997.
                                                      Registration No. 333-_____
- --------------------------------------------------------------------------------

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM S-3
                                        

                             REGISTRATION STATEMENT
                                     Under
                           THE SECURITIES ACT OF 1933
                                        
                               GENSIA SICOR INC.
             (Exact name of registrant as specified in its charter)

         Delaware                                      33-0176647
(State or other jurisdiction               (I.R.S. Employer Identification No.)
 of incorporation or organization)   

                            9360 Towne Centre Drive
                          San Diego, California 92121
                                 (619) 546-8300
         (Address, including zip code, and telephone number, including
             area code of registrant's principal executive offices)

                                                
                                  DAVID F. HALE      
                       President and Chief Executive Officer           
                                 Gensia Sicor Inc.   
                              9360 Towne Centre Drive
                            San Diego, California 92121
                                  (619) 546-8300           
(Name, address, including zip code, and telephone number, including area code,
 of agent for service)

                                    Copies to:                 
                            THOMAS E. SPARKS, JR., ESQ.                
                           Pillsbury Madison & Sutro LLP  
                                 P.O. Box 7880
                            San Francisco, CA 94120-7880    
                                   (415) 983-1000  

Approximate date of commencement of proposed sale to the public: From time to
time after the effective date of this Registration Statement as determined by
the Selling Stockholders.

If the only securities being registered on this Form are being offered pursuant
to dividend or interest reinvestment plans, please check the following box: [ ]

If any of the securities being registered on this Form are to be offered on a
delayed or continuous basis pursuant to Rule 415 under the Securities Act of
1933, other than securities offered only in connection with dividend or interest
reinvestment plans, please check the following box: [X]

If this Form is filed to register additional securities for an offering pursuant
to Rule 462(b) under the Securities Act, please check the following box and list
the Securities Act registration statement number of the earlier effective
registration statement for the same offering: [X] 333-35719

If this Form is a post-effective amendment filed pursuant to Rule 462(c) under
the Securities Act, check the following box and list the Securities Act
registration statement number of the earlier effective registration statement
for the same offering: [ ]

If delivery of the prospectus is expected to be made pursuant to Rule 434,
please check the following box: [ ]

                                _______________
<TABLE> 
<CAPTION> 

                                     CALCULATION OF REGISTRATION FEE
======================================================================================================== 
      Title of each class of               Proposed maximum aggregate                                
    securities to be registered                offering price(1)           Amount of registration fee 
- ---------------------------------------------------------------------------------------------------------
<S>                                            <C>                               <C>
     Common Stock, $.01 par value                 $750,000                         $228

======================================================================================================== 
</TABLE>
                                        
(1)  Estimated solely for the purpose of calculating the registration fee
     pursuant to Rule 457(o).
<PAGE>
 
               INCORPORATION OF CERTAIN INFORMATION BY REFERENCE

     This Registration Statement is filed with the Securities and Exchange
Commission (the "Commission") under the Securities Act of 1933, as amended (the
"Act") by Gensia Sicor Inc. (the "Company"), pursuant to Rule 462(b) under the
Act. This Registration Statement incorporates by reference the contents of the
Registration Statement on Form S-3 (File No. 333-35719) relating to the
registration for resale of up to $5,322,500 worth of Common Stock of the
Company.


                                 CERTIFICATION

     The Company hereby certifies to the Commission that (i) it has instructed
its bank to pay the Commission the filing fee set forth on the cover page of
this Registration Statement by a wire transfer of such amount to the
Commission's account at Mellon Bank as soon as practicable (but no later than
the close of business on October 7, 1997), (ii) it will not revoke such
instructions, (iii) it has sufficient funds in the relevant account to cover the
amount of such filing fee, and (iv) it will confirm receipt of such instructions
by the bank during regular business hours on October 7, 1997.
<PAGE>
 
                                   SIGNATURES
                                   ----------


     Pursuant to the requirements of the Securities Act of 1933, the registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-3, and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of San Diego, State of California, September 30, 1997.

                                        GENSIA SICOR INC.


                                        By   /s/ David F. Hale*
                                           -------------------------------
                                                 David F. Hale
                                                 President and
                                                 Chief Executive Officer
<TABLE> 
<CAPTION> 

    Signature                                Title                                   Date
    ---------                                -----                                   ----  
<S>                            <C>                                            <C> 

/s/   David F. Hale*            President, Chief Executive Officer              September 30, 1997
- --------------------------      and Director (Principal Executive Officer) 
      David F. Hale
     
/s/  John W. Sayward            Vice President, Finance, Chief                  September 30, 1997 
- --------------------------      Financial Officer, and Treasurer  
     John W. Sayward            (Principal Financial and Principal
                                Accounting Officer)
                                                        

/s/ Donald E. Panoz*            Chairman of the Board                           September 30, 1997 
- ---------------------------  
     Donald E. Panoz
 

/s/ James C. Blair, Ph.D.*            Director                                  September 30, 1997 
- ----------------------------       
    James C. Blair, Ph.D.
  

/s/ Michael D. Cannon*                Director                                  September 30, 1997 
- ----------------------------     
    Michael D. Cannon
                                                         

/s/ Herbert J. Conrad*                Director                                  September 30, 1997  
- ----------------------------
    Herbert J. Conrad
</TABLE> 
  
<PAGE>
 
<TABLE> 
<CAPTION> 

    Signature                                Title                                   Date
    ---------                                -----                                   ----  
<S>                                     <C>                                   <C> 

/s/ Carlos A. Ferrer*                    Director                               September 30, 1997
- ---------------------------
    Carlos A. Ferrer


/s/  Carlo Salvi*                        Director                               September 30, 1997
- ----------------------------
     Carlo Salvi


/s/ Patrick D. Walsh*                    Director                               September 30, 1997
- ----------------------------
    Patrick D. Walsh
  

/s/  L. John Wilkerson, Ph.D.*           Director                               September 30, 1997
- ------------------------------
     L. John Wilkerson, Ph.D.
  

By: /s/ John W. Sayward
    --------------------------
        John W. Sayward
        Attorney-in-Fact
</TABLE> 
<PAGE>
 
                                 EXHIBIT INDEX
<TABLE> 
<CAPTION> 

EXHIBIT
Number                         Description of Document
- ------                         -----------------------
<C>         <S> 
5.1          Opinion of Pillsbury Madison & Sutro LLP regarding the legality of
             the securities being offered.

23.1         Consent of Ernst & Young LLP, independent auditors.

23.2         Consent of KPMG Accountants N.V., independent auditors.

23.3         Consent of Pillsbury Madison & Sutro LLP (included in its opinion
             filed as Exhibit 5.1 to this Registration Statement).
</TABLE> 

<PAGE>
 
                                                                     EXHIBIT 5.1

                         PILLSBURY MADISON & SUTRO LLP
                                 P.O. BOX 7880
                            SAN FRANCISCO, CA 94120
                              Tel: (415) 983-1000
                              Fax: (415) 983-1200

                                October 6, 1997

Gensia Sicor Inc.
9360 Towne Center Drive
San Diego, California 92121

             Re:  Registration Statement on Form S-3 (File No. 333-35719) and 
                  Registration Statement filed pursuant to Rule 462(b) under the
                  Securities Act for the same offering (the "Registration
                  Statements")

Ladies and Gentlemen:

          We are acting as counsel for Gensia Sicor Inc., a Delaware corporation
(the "Company"), in connection with the registration under the Securities Act of
1933, as amended, of the resale of 814,248 shares of Common Stock, par value
$.01 per share (the "Common Stock"), of the Company, to be issued as a milestone
payment by the Company to the limited partners of Gensia Clinical Partners, L.P.
(the "Selling Stockholders"). In this regard we have participated in the
preparation of the Registration Statements relating to such shares of Common
Stock.

          We are of the opinion that the shares of Common Stock to be offered
and sold by the Selling Stockholders have been duly authorized and are legally
issued, fully paid and nonassessable.
 
          We hereby consent to the filing of this opinion as Exhibit 5.1 to the
Registration Statements and to the use of our name under the caption "Legal
Matters" in the Registration Statements and in the Prospectus included therein.

                                 Very truly yours,

                                 /s/ Pillsbury Madison & Sutro LLP

<PAGE>
 
                                                                    EXHIBIT 23.1

               CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS

We consent to the reference to our firm under the caption "Experts" in the
Registration Statement on Form S-3 filed pursuant to Rule 462(b) and
related Prospectus of Gensia Sicor Inc. for the registration of shares of its
common stock and to the incorporation by reference therein of our report dated
February 21, 1997, except for Note 11 as to which the date is March 27, 1997,
with respect to the consolidated financial statements of Gensia Sicor Inc.
included in its Annual Report (Form 10-K/A) for the year ended December 31,
1996, filed with the Securities and Exchange Commission.

                                         /s/ Ernst & Young LLP


San Diego, California
September 30, 1997

<PAGE>
 
                                                                    EXHIBIT 23.2


The Board of Directors
Gensia Sicor Inc.

We consent to the incorporation by reference of our report dated April 28, 1997,
with respect to the consolidated balance sheet of Rakepoll Holding B.V. and 
subsidiaries as of December 31, 1996 and 1995, and the related consolidated 
statements of operations, stockholders' equity and cash flows for each of the 
years in the three year period ended December 31, 1996, which report is 
incorporated by reference in the Form S-3 of Gensia Sicor Inc. and to the 
reference to our firm under the heading "Experts" in the prospectus.

Rotterdam, October 2, 1997

/s/ KPMG Accountants NV

Ref.: A. Vermaas


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