KNOTT DAVID M
SC 13D, 1998-07-16
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<PAGE>
 
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, DC  20549

                                  SCHEDULE 13D

                    Information to be Included in Statements
                   Filed Pursuant to 13d-1(a) and Amendments
                       thereto filed pursuant to 13d-2(a)

                          COLUMBIA LABORATORIES, INC.
                                (Name of Issuer)

                          COMMON STOCK $ .01 PAR VALUE
                         (Title of Class of Securities)

                                   197779101
                                 -----------------
                                 (CUSIP Number)

                                 DAVID M. KNOTT
                      485 UNDERHILL BOULEVARD, SUITE 205,
                  SYOSSET, NEW YORK 11791-3419 (516) 364-0303
          (Name, Address and Telephone Number of Person Authorized to
                      Receive Notices and Communications)

                                  JULY 6, 1998
            (Date of Event which Requires Filing of this Statement)



If the filing person has previously filed a statement on Schedule 13G to report
the acquisition which is the subject of this Schedule 13D, and is filing this
schedule because of Rule 13d-1(b)(3) or (4), check the following box [ ].


Note:  Six copies of this statement, including all exhibits, should be filed
with the Commission.  See Rule 13d-1(a) for other parties to whom copies are to
be sent.

                         (continued on following pages)

                                  Page 1 of 11
<PAGE>
 
                                  SCHEDULE 13D

CUSIP No.197779101

<TABLE>
<S>       <C>                                                            <C> 
=================================================================================================== 
1           Name of Reporting Person                                             David M. Knott
            S.S. or I.R.S. Identification No. of above Person                    SS# ###-##-####
- --------------------------------------------------------------------------------------------------- 
2           Check the Appropriate Box if a Member of a Group*                    (a) [X ]
                                                                                 (b) [  ]
- ---------------------------------------------------------------------------------------------------
3           SEC Use Only
- --------------------------------------------------------------------------------------------------- 
4           Source of Funds*                                                     PF, OO
- --------------------------------------------------------------------------------------------------- 
5           Check Box if Disclosure of Legal Proceeding is Required
            Pursuant to Items 2(d) or 2(e)                                       [ ]
- --------------------------------------------------------------------------------------------------- 
6           Citizenship or Place of Organization                                 U.S.A.
- --------------------------------------------------------------------------------------------------- 
Number of          7          Sole Voting Power                                 917,900
Shares               

Beneficially       8          Shared Voting Power                                82,600
Owned by

Each               9          Sole Dispositive Power                            917,900
Reporting

Person            10          Shared Dispositive Power                           89,200 
With
- ----------------------------------------------------------------------------------------------------
11  Aggregate Amount Beneficially Owned by Each Reporting Person              1,007,100
- ---------------------------------------------------------------------------------------------------- 
12  Check Box if the Aggregate Amount in Row (11) Excludes
    Certain Shares*                                                               [ ]               
- ---------------------------------------------------------------------------------------------------
13  Percent of Class Represented by Amount in Row (11)                            3.5 %
- ---------------------------------------------------------------------------------------------------
14  Type of Reporting Person*                                                     IN
===================================================================================================
</TABLE>


                     *SEE INSTRUCTIONS BEFORE FILLING OUT!

                                  Page 2 of 11
<PAGE>
 
                                  SCHEDULE 13D

CUSIP No.197779101

<TABLE>
<S>     <C>                                                         <C>                                       
==================================================================================================== 
1         Name of Reporting Person                                      Knott Partners. L.P.        
          S.S. or I.R.S. Identification No. of above Person             TIN# 11-2835793
- --------------------------------------------------------------------------------------------------- 
2         Check the Appropriate Box if a Member of a Group*                      (a)  [X]
                                                                                 (b)  [ ]
- --------------------------------------------------------------------------------------------------- 
3         SEC Use Only
- --------------------------------------------------------------------------------------------------- 
4         Source of Funds*                                                         WC
- --------------------------------------------------------------------------------------------------- 
5         Check Box if Disclosure of Legal Proceeding is Required
          Pursuant to Items 2(d) or 2(e)                                              [ ]
- --------------------------------------------------------------------------------------------------- 
6         Citizenship or Place of Organization                                       U.S.A.
- --------------------------------------------------------------------------------------------------- 
Number of                            7          Sole Voting Power                  524,000
Shares

Beneficially                         8          Shared Voting Power               
Owned by

Each                                 9          Sole Dispositive Power            524,000
Reporting

Person                              10          Shared Dispositive Power         
With
- ---------------------------------------------------------------------------------------------------
11  Aggregate Amount Beneficially Owned by Each Reporting Person                  524,000 
- --------------------------------------------------------------------------------------------------- 
12  Check Box if the Aggregate Amount in Row (11) Excludes
    Certain Shares*                                                                 [ ]
- --------------------------------------------------------------------------------------------------- 
13  Percent of Class Represented by Amount in Row (11)                              1.8 %
- ---------------------------------------------------------------------------------------------------
14  Type of Reporting Person*                                                       PN
===================================================================================================
</TABLE>
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!

                                  Page 3 of 11
<PAGE>
 
                                  SCHEDULE 13D

CUSIP No.197779101

<TABLE>
<S>     <C>                                                  <C>                         
====================================================================================================
1        Name of Reporting Person                                   Dorset Management Corporation
         S.S. or I.R.S. Identification No. of above Person              TIN# 11-2873658
- ---------------------------------------------------------------------------------------------------- 
2        Check the Appropriate Box if a Member of a Group*                         (a) [X]
                                                                                   (b) [ ]
- ---------------------------------------------------------------------------------------------------- 
3        SEC Use Only
- ---------------------------------------------------------------------------------------------------- 
4        Source of Funds*                                                               00
- ---------------------------------------------------------------------------------------------------- 
5        Check Box if Disclosure of Legal Proceeding is Required
         Pursuant to Items 2(d) or 2(e)                                                [ ]
- ---------------------------------------------------------------------------------------------------- 
6        Citizenship or Place of Organization                                         U.S.A.
- ---------------------------------------------------------------------------------------------------- 
Number of               7          Sole Voting Power                                 345,700
Shares

Beneficially            8          Shared Voting Power                                75,400
Owned by

Each                    9          Sole Dispositive Power                            345,700
Reporting
                       
Person                 10           Shared Dispositive Power                         75,400
With
- ----------------------------------------------------------------------------------------------------
11  Aggregate Amount Beneficially Owned by Each Reporting Person                    421,100
- ---------------------------------------------------------------------------------------------------- 
12  Check Box if the Aggregate Amount in Row (11) Excludes
    Certain Shares*
- ---------------------------------------------------------------------------------------------------- 
13  Percent of Class Represented by Amount in Row (11)                                1.5 %
- ----------------------------------------------------------------------------------------------------
14  Type of Reporting Person*                                                          CO
====================================================================================================
</TABLE>


                     *SEE INSTRUCTIONS BEFORE FILLING OUT!

                                  Page 4 of 11
<PAGE>
 
                                  SCHEDULE 13D

CUSIP No.197779101

<TABLE>
<CAPTION> 

<S>    <C>                                              <C>                          
====================================================================================================
1        Name of Reporting Person                                 Mattterhorn Offshore Fund  Limited
         S.S. or I.R.S. Identification No. of above Person                           N/A
- ----------------------------------------------------------------------------------------------------- 
2        Check the Appropriate Box if a Member of a Group*                   (a) [X]
                                                                             (b) [ ]
- ---------------------------------------------------------------------------------------------------- 
3        SEC Use Only
- ----------------------------------------------------------------------------------------------------- 
4        Source of Funds*                                                     WC
- ----------------------------------------------------------------------------------------------------- 
5        Check Box if Disclosure of Legal Proceeding is Required
         Pursuant to Items 2(d) or 2(e)                                           [ ]  
- ----------------------------------------------------------------------------------------------------- 
6        Citizenship or Place of Organization                                 British Virgin Islands.
- ----------------------------------------------------------------------------------------------------- 
Number of                 7        Sole Voting Power       
Shares

Beneficially              8        Shared Voting Power                        75,400
Owned by

Each                      9        Sole Dispositive Power    
Reporting

Person                   10           Shared Dispositive Power                75,400
With
- -------------------------------------------------------------------------------------------------- 
11  Aggregate Amount Beneficially Owned by Each Reporting Person              75,400
- -------------------------------------------------------------------------------------------------- 
12  Check Box if the Aggregate Amount in Row (11) Excludes
    Certain Shares*                                                            [ ]
- -------------------------------------------------------------------------------------------------- 
13  Percent of Class Represented by Amount in Row (11)                         0.3 %
- --------------------------------------------------------------------------------------------------
14  Type of Reporting Person*                                                  CO
===================================================================================================
</TABLE>


                     *SEE INSTRUCTIONS BEFORE FILLING OUT!

                                  Page 5 of 11
<PAGE>
 
                                 SCHEDULE 13-D

ITEM 1.  SECURITY AND ISSUER

          The class of securities to which this statement relates is the common
stock, par value $.01 per share (the "Common Stock"), of Columbia Laboratories,
Inc., a Delaware corporation (the "Company"), the address of which is 2665 South
Bayshore Drive, Miami, FL 33133 (Tel.: 305-860-1670).

ITEM 2.  IDENTITY AND BACKGROUND

          This statement is being filed by (i) David M. Knott, an individual
whose business address is 485 Underhill Boulevard, Syosset, New York  11791,
(ii) Knott Partners, L.P., whose business address is also 485 Underhill
Boulevard, Syosset, New York  11791, (iii) Dorset Management Corporation, whose
business address is also 485 Underhill Boulevard, Syosset, New York  11791, and
(iv) Matterhorn Offshore Fund Limited, whose business address is c/o Citco Fund
Services (Curacao) N.V., Kaya Flamboyan 9, P.O. Box 707, Curacao, Netherlands
Antilles.

          David M. Knott files this statement on his own behalf and on behalf of
his wife, their individual retirement accounts and their minor children.

          He also files this statement as the sole general partner of Knott
Partners, L.P. (the "Partnership"), a New Jersey limited partnership that
invests in securities that are sold in the public markets.  The Partnership's
principal activity is the acquisition of long and short positions in equity
securities of publicly traded U.S. and foreign securities.  The Partnership has
the authority to employ various trading and hedging techniques and strategies in
connection therewith.

          Mr. Knott is also the sole shareholder, Director and President of
Dorset Management Corporation, a New York corporation ("Dorset"), which provides
portfolio management services to a limited number of foreign and domestic
individuals and entities, including Matterhorn Offshore Fund Limited
("Matterhorn"), a British Virgin Islands corporation whose principal activity is
the acquisition of long and short positions in equity securities of publicly
traded U.S. and foreign corporations.

          Matterhorn's sole director is Inter Caribbean Services, Ltd., an
affiliate of Citco B.V.I. Limited ("CBVI"), a British Virgin Islands corporation
whose business address is c/o Citco B.V.I. Limited, Wickhams Cay, P.O. Box 662,
Road Town, Tortola, British Virgin Islands. The name, address and principal
occupation or employment of each of the directors of Inter Caribbean Services,
Ltd..is as follows:
<TABLE>
<CAPTION>
<S>                 <C>                      <C>  
Name                         Address                Principal Occupation or Employment
- -------------------  ------------------------  --------------------------------------------
Kariem Abdellatif    c/o Citco B.V.I. Limited            Managing Director, CBVI
Fay Roberts          c/o Citco B.V.I. Limited       Assistant Managing Director, CBVI
A. J. Stocks         c/o Citco B.V.I. Limited  Director, Citco Fund Services (Curacao) N.V.
</TABLE>

                                  Page 6 of 11
<PAGE>
 
          During the last five years, neither Mr. Knott nor any of the other
persons named above has been convicted in any criminal proceeding, nor has or
any such other person been a party to a civil proceeding of a judicial or
administrative body of competent jurisdiction as a result of which he was or is
subject to any judgment, decree or final order enjoining future violations of,
or prohibiting or mandating activities subject to, federal or state securities
laws, or finding any violation with respect to such laws.

          Mr. Knott, Mrs. Knott and their children are all citizens of the
United States of America.  Mr. Abdellatif is a Dutch citizen, Fay Roberts is a
citizen of the British Virgin Islands, and Mr. Stocks is a British citizen.
 .


ITEM 3.  SOURCE AND AMOUNT OF FUNDS OR OTHER CONSIDERATION

          The source of funds used by Mr. Knott in purchasing the Common Stock
directly for his own account and for the accounts of the above-named members of
his immediate family was their respective personal funds.  The source of funds
used in making each of the acquisitions of the Common Stock purchased indirectly
by Mr. Knott through the Partnership, the other persons named in Item 2 above
and certain other accounts for which Dorset provides management services on
whose behalf the Common Stock was acquired was the portfolio assets of the
Partnership and each of such other persons.

          The aggregate amount of consideration used by Mr. Knott in making such
acquisitions was $11,045,443.  This amount includes all purchases of the Common
Stock made by Mr. Knott, including those purchases made more than 60 days from
the date of this filing.  The aforementioned sources and amount of funds are
more particularly set forth below:

<TABLE>
<CAPTION>
SOURCE                                                                       AMOUNT
- -------------------------------------------------------------------------  -----------
<S>                                                                        <C>
Mr. David M. Knott (includes Mr. Knott's IRA)                              $   586,950
Mrs. David M. Knott (includes Mrs. Knott's IRA and the accounts of the         166,041
 Knotts' minor children)
Knott Partners, L.P.                                                         5,396,662
Matterhorn Offshore Fund Limited                                               686,546
The Common Fund                                                              2,805,234
GAM Knott Hedge Investments, Inc.                                              905,753
Trinkaus Optima US Equities                                                    478,681
Leonard & Margaret Frierman                                                     19,576
                                                                           -----------
     TOTAL                                                                 $11,045,443
                                                                           ===========
</TABLE>

                                  Page 7 of 11
<PAGE>
 
ITEM 4.  PURPOSE OF TRANSACTION

          The acquisition of the Common Stock by Mr. Knott and the other persons
named in Item 2 above was originally made solely for investment purposes, and
not with a view towards influencing any extraordinary corporate transaction, any
change in the Company's board of directors or management or any other change in
the Company's business, corporate structure or capitalization.

          Following conversations with the persons named in the response to Item
6 below, efforts to participate on or otherwise change the Company's board of
directors or management and/or changes in the Company's business strategy may be
pursued by Mr. Knott, either alone or in conjunction with such other persons.


ITEM 5.  INTEREST IN SECURITIES OF THE COMPANY

          (a)  Mr. Knott beneficially owns 1,007,100 shares of the Company's
Common Stock, which represents 3.5% of all outstanding Common Stock of the
Company and includes all of the shares beneficially owned by the persons named
below in this Paragraph (a).

          The Partnership beneficially owns 524,000 shares of the Company's
Common Stock, which represents 1.8% of all outstanding Common Stock of the
Company.

          Dorset beneficially owns 421,100 shares of the Company's Common Stock,
which represents 1.5% of all outstanding Common Stock of the Company and
includes all of the shares beneficially owned by Matterhorn.

          Matterhorn beneficially owns 75,400 shares of the Company's Common
Stock, which represents 0.3% of all outstanding Common Stock of the Company.

          (b) Mr. Knott individually (i) has the sole power to vote and to
dispose of (1) 48,200 shares of the Company's Common Stock held in his and his
IRA's accounts and (2) 524,000 shares held in the Partnership's account, (ii)
shares with the respective account owners the power to vote and to dispose of
7,200 shares held by the accounts of Mr. Knott's minor children, and (iii)
shares with the respective account owners the power to dispose of (but not to
vote) 6,600 shares held by the accounts of Mrs. Knott and her IRA.

          As President of Dorset, Mr. Knott (iv) has the sole power to vote and
to dispose of 345,700 shares of the Company's Common Stock and (v) shares with
the respective account owner the power to vote and to dispose of 75,400 shares
held in Matterhorn's account.

          The Partnership (except through its sole general partner, Mr. Knott)
neither holds nor shares with any person the power to vote or to dispose of the
Company's Common Stock.

          Matterhorn shares with Dorset and Mr. Knott the power to vote and to
dispose of 75,400 shares held by Matterhorn.

                                  Page 8 of 11
<PAGE>
 
          (c)  Each transaction in the Common Stock made by the persons named in
Paragraph (a) of this Item 5 during the past 60 days is described on Schedule 1
annexed hereto.  All such transactions were effected in the open market in
ordinary brokerage transactions through various broker-dealer firms.

          (d)  Of the 1,007,100 shares of Common Stock beneficially owned by Mr.
Knott, all but the 55,400 shares held in his and his IRA's accounts and the
accounts of his minor children are owned on behalf of other persons or entities
having the right to receive and the power to direct the receipt of dividends
from, and proceeds from the sale of, such shares.  No individual person or
entity has such right with regard to greater than five percent of the class of
Common Stock.

          (e)  Not applicable.


ITEM 6.  CONTRACTS, ARRANGEMENTS, UNDERSTANDINGS OR RELATIONSHIPS WITH RESPECT
TO SECURITIES OF THE COMPANY

          Mr. Knott is the general partner of the Partnership and acts on its
behalf in accordance with its agreement of limited partnership.  Through Dorset,
Mr. Knott manages Matterhorn's securities portfolio pursuant to a written
portfolio management agreement. Except as noted, there are no contracts,
arrangements, understandings or relationships (legal or otherwise) among the
persons named in Item 2 above.

          Mr. Knott has had conversations with Messrs. James Apostolakis and
Anthony R. Campbell and others, including members of the Company's management,
concerning the Company's recent performance with a view to effecting changes in
the Company's board of directors or management and/or changes in the Company's
business strategy.  Notwithstanding these conversations, to date no arrangements
or understandings have been reached with management of the Company.  Mr. Knott
has agreed on behalf of the persons named in Item 2 above, to share with Messrs
Apostolakis and Campbell and certain other persons and entities affiliated with
them the costs of common counsel to pursue these activities.  Accordingly, such
persons may be deemed to constitute a group, the other members of which are
filing separate Schedules 13D.


ITEM 7.  MATERIALS TO BE FILED AS EXHIBITS

          Not applicable.

                                  Page 9 of 11
<PAGE>
 
                                   SIGNATURE
                                   ---------

          After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.



                                /s/ David M. Knott
                               ----------------------------------
                               DAVID M. KNOTT



                              KNOTT PARTNERS, L.P.


                              By: /s/ David M. Knott
                                  -------------------------------
                                  David M. Knott, General Partner



                              DORSET MANAGEMENT CORPORATION


                              By: /s/ David M. Knott
                                  -------------------------------
                                  David M. Knott, President


 
                              MATTERHORN OFFSHORE FUND LIMITED

                              By:  Inter Caribbean Services, Ltd., Sole Director


                              By: /s/ Wiekert Weber
                                  ------------------------------------
                                    Wiekert Weber, Attorney-in-Fact A
                                    ----------------------------------



Dated:    July 16, 1998

                                 Page 10 of 11
<PAGE>
 
<TABLE>
<CAPTION>
TRANSACTION         PERSON NAMED IN                                     NUMBER     PRICE PER
- -----------                                    TRANSACTION TYPE      ------------  ----------
DATE             ITEM 5, PARAGRAPH (A)      -----------------------   OF SHARES    SHARE ($)
- -----------  -----------------------------                           ------------  ----------
<C>          <S>                            <C>                      <C>           <C>
    5/12/98  Mr. Knott/Partnership                 Purchase                 3,600       9.45
    5/12/98  Mr. Knott/Dorset/Matterhorn           Purchase                 2,400       9.45
    6/01/98  Mr. Knott/Dorset/Matterhorn    Redemption Distribution       (90,900)/1/   8.44
    6/01/98  Mr. Knott/Dorset                Capital Contribution          90,900 /1/   8.44
    6/02/98  Mr. Knott/Dorset/Matterhorn           Purchase                10,000       7.51
    6/04/98  Mr. Knott/Dorset/Matterhorn           Purchase                10,000       7.00
    6/08/98  Mr. Knott/Dorset/Matterhorn           Purchase                12,000       7.18
    6/11/98  Mr. Knott/Dorset                        Sale                 (18,000)/2/   6.80
    6/11/98  Mr. Knott/Dorset/Matterhorn           Purchase                 6,000 /2/   6.82
    6/11/98  Mr. Knott/Dorset                      Purchase                12,000 /2/   6.82
    6/12/98  Mr. Knott/Dorset                      Purchase                 5,700       6.96
    6/12/98  Mr. Knott/Dorset/Matterhorn           Purchase                 3,300       6.96
    6/12/98  Mr. Knott/Partnership                 Purchase                 4,000       6.96
    6/17/98  Mr. Knott/Dorset/Matterhorn           Purchase                 2,000       6.20
    6/17/98  Mr. Knott/Partnership                 Purchase                 8,000       6.20
    6/19/98  Mr. Knott/Partnership                 Purchase                 8,000       6.24
    6/22/98  Mr. Knott/Dorset                      Purchase                 5,000       6.18
    6/25/98  Mr. Knott/Dorset                      Purchase                 4,000       6.25
    6/25/98  Mr. Knott/Partnership                 Purchase                 8,000       6.25
    6/30/98  Mr. Knott/Dorset                      Purchase                 1,400       5.92
    6/30/98  Mr. Knott/Partnership                 Purchase                 4,000       5.92
    6/30/98  Mr. Knott/Dorset/Matterhorn           Purchase                   600       5.92
    7/08/98  Mr. Knott/Dorset                      Purchase                 4,000       5.54
    7/08/98  Mr. Knott/Partnership                 Purchase                14,000       5.54
    7/08/98  Mr. Knott/Dorset/Matterhorn           Purchase                 2,000       5.54
    7/09/98  Mr. Knott/Partnership                 Purchase                10,000       7.08
</TABLE>
________________________________

/1/  These are related transactions not involving a purchase or sale 
which reduced Matterhorn's beneficial ownership but  did not change the
total number of shares beneficially owned by Mr. Knott or by Dorset as of 
such date.         
 

/2/  These transactions represent crossed stock exchange transactions in which
shares were purchased and sold by certain accounts managed by Mr. Knott/Dorset
such that the total number of shares beneficially owned by Mr. Knott and by
Dorset as of such date did not change.

                                 Page 11 of 11


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