BIOJECT MEDICAL TECHNOLOGIES INC
DEF 14A, 1998-01-28
SURGICAL & MEDICAL INSTRUMENTS & APPARATUS
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                                  SCHEDULE 14A
                                 (Rule 14a-101)

                                 AMENDMENT NO. 3

                      
                      INFORMATION REQUIRED IN PROXY STATEMENT
                               SCHEDULE 14A INFORMATION

                      Proxy Statement Pursuant to Section 14(a)
                       of the Securities Exchange Act of 1934

Filed by the Registrant [x]
Filed by a Party other than the Registrant 

Check the appropriate box:
[ ]  Preliminary Proxy Statement   [ ]Confidential, for Use of the 
                                      Commission Only (as permitted by 
                                      Rule 14a-6(e)(2))

[X]  Definitive Proxy Statement
[ ]  Definitive Additional Materials
[ ]  Soliciting Material Pursuant to Rule 240.14a-11(c) or Rule    
      240.14a-12

                 Bioject Medical Technologies Inc.
          (Name of Registrant as Specified in Its Charter)

                          James C. O'Shea
                     Chief Executive Officer
                Bioject Medical Technologies Inc.
                    7620 S.W. Bridgeport Road
                     Portland, Oregon  97224
              (Name of Person Filing Proxy Statement)

Payment of Filing Fee (Check the appropriate box):

[ ]   $125 per Exchange Act Rules 0-11(c)(1)(ii), 14a-6(i)(1), 
      or 14a-6(i)(2), or Item 22(a)(2) of Schedule 14A.

[ ]   $500 per each party to the controversy pursuant to Exchange Act           
      Rule 14a-6(i)(3).

[ ]   Fee computed on table below per Exchange Act Rules 14a-6(i)(4) 
      and 0-11.

 1)    Title of each class of securities to which transaction applies:

 2)   Aggregate number of securities to which transaction applies:

 3)   Per unit price or other underlying value of transaction computed 
      pursuant to Exchange Act Rule 0-11 (Set forth the amount on which 
      the filing fee is calculated and state how it was determined):

 4)   Proposed maximum aggregate value of transaction:

 5)   Total fee paid:

[ ]   Fee paid previously with preliminary materials.

[ ]   Check box if any part of the fee is offset as provided by Exchange 
      Act Rule 0-11(a)(2) and identify the filing for which the      
      offsetting fee was paid previously.  Identify the previous filing   
      by registration statement number, or the Form or Schedule and the 
      date of its filing.

    1)  Amount Previously Paid:

    2)  Form, Schedule or Registration Statement No.:

    3)  Filing Party:

    4)  Date Filed:

<PAGE>

                                     Bioject Medical Technologies Inc.
                                     7620 SW Bridgeport Road
                                     Portland, Oregon 97224
                                     Telephone (503) 639-7221
                                     Fax (503) 624-9002

January 28, 1998


Dear Shareholders:


You are cordially invited to attend a Special Meeting of 
Shareholders at the Company's headquarters, 7620 S.W. Bridgeport Road, 
Portland, Oregon, on February 20, 1998, at 1:00 p.m., Pacific Standard 
Time.



The Special Meeting has been called for the purpose of voting on 
three proposals relating to the Company's recent transactions with Elan 
Corporation, plc ("Elan plc") and its wholly-owned subsidiary, Elan 
International Services, Ltd. ("Elan"), and Raphael, LLC, a 
management consulting firm, for services it rendered in connection 
with the transactions with Elan and Elan plc.  These transactions, as 
more fully described in the accompanying Proxy Statement, present the 
Company with an exciting opportunity in the field of glucose 
monitoring for diabetics.  The proposals are to approve (1) the exchange 
of a promissory note in the original principal amount of $12.015 
million issued by the Company to Elan for approximately 832,000 shares 
of the Company's Series A and Series B Convertible Preferred Stock, 
(2) the issuance of the Company's Series C Convertible Preferred 
Stock or substantially similar convertible preferred stock in 
connection with future funding of glucose monitoring research and 
development and (3) the issuance to Raphael, LLC, of a warrant to 
purchase 100,000 shares of the Company's Common Stock.


Your Board of Directors unanimously recommends that you vote FOR
each of the proposals.

Whether or not you are able to attend the meeting, it is 
important that your shares be represented, no matter how many shares 
you own.  We urge you to mark, sign, date and mail your proxy promptly 
in the envelope provided.

On behalf of the Board of Directors, thank you for your continued 
support of the Company.  We look forward to greeting you personally at 
the meeting or receiving your proxy.

                               Sincerely,


                               /s/ James C. O'Shea
                               James C. O'Shea
                               Chairman of the Board,
                               President and
                               Chief Executive Officer
<PAGE>

                    BIOJECT MEDICAL TECHNOLOGIES INC.
                
                NOTICE OF SPECIAL MEETING OF SHAREHOLDERS 
                      TO BE HELD ON February 20, 1998
                

To the Shareholders of 
BIOJECT MEDICAL TECHNOLOGIES INC.:


A Special Meeting of Shareholders of Bioject Medical Technologies 
Inc., an Oregon corporation (the "Company"), will be held at the 
Company's principal executive offices, 7620 S.W. Bridgeport Road, 
Portland, Oregon, on February 20, 1998 at 1:00 p.m., Pacific Standard 
Time, for the purpose of voting on three proposals.  



The Company seeks approval of the following three proposals: 
(1) the exchange of a promissory note in
the original principal amount of $12.015 million previously issued by 
the Company to Elan International Services, Ltd., for approximately 
698,000 shares of the Company's Series A Convertible Preferred Stock 
and approximately 134,000 shares of the Company's Series B Convertible
Preferred Stock, (2) the issuance and sale of the Company's Series C
Convertible Preferred Stock or substantially similar convertible preferred
stock to fund future research in the field of glucose monitoring and (3) the
issuance of a warrant to purchase 100,000 shares of the Company's Common
Stock to Raphael, LLC, a management consulting firm, for services it rendered
in connection with the transactions.



The Board of Directors has fixed December 23, 1997, as the record 
date for the determination of shareholders entitled to notice of and 
to vote at the meeting.


ALL SHAREHOLDERS ARE CORDIALLY INVITED TO ATTEND THE MEETING.  
YOU ARE URGED TO SIGN, DATE AND OTHERWISE COMPLETE THE ENCLOSED PROXY 
CARD AND RETURN IT PROMPTLY IN THE ENCLOSED ENVELOPE WHETHER OR NOT YOU 
PLAN TO ATTEND THE MEETING.  IF YOU ATTEND THE MEETING, YOU MAY VOTE 
YOUR SHARES IN PERSON EVEN IF YOU HAVE SIGNED AND RETURNED YOUR PROXY 
CARD.
                              By Order of the Board of Directors,


                              /s/ Peggy J. Miller
                              Peggy Jarvis Miller
                              Vice President, Chief Financial
                              Officer and Secretary/Treasurer

<PAGE>                
                      BIOJECT MEDICAL TECHNOLOGIES INC.
                             TABLE OF CONTENTS
                      


SPECIAL MEETING OF SHAREHOLDERS February 20, 1998


VOTING
  
SECURITY OWNERSHIP BY PRINCIPAL SHAREHOLDERS AND MANAGEMENT
  
THE ELAN TRANSACTIONS AND THEIR RELATIIONSHIP TO THE PROPOSAL

DESCRIPTION OF THE PROMISSORY NOTE

DESCRIPTION OF THE PREFERRED STOCK

PROPOSAL #1: APPROVAL OF THE EXCHANGE OF A PROMISSORY NOTE FOR SERIES A
             AND SERIES B CONVERTIBLE PREFERRED STOCK

PROPOSAL #2: APPROVAL OF THE FUTURE ISSUANCE OF SERIES C CONVERTIBLE
             PREFERRED STOCK OR OTHER SIMILAR CONVERTIBLE PREFERRED STOCK
             TO ELAN

PROPOSAL #3: APPROVAL OF THE ISSUANCE OF A WARRANT TO PURCHASE 100,000 SHARES
             OF COMMON STOCK


INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE

OTHER MATTERS

APPENDIX A


EXHIBITS: DOCUMENTS INCORPORATED BY REFERENCE

<PAGE> 


                  BIOJECT MEDICAL TECHNOLOGIES INC.
                     7620 S.W. BRIDGEPORT ROAD
                      PORTLAND, OREGON  97224

                         PROXY STATEMENT
                     
                     SPECIAL MEETING OF SHAREHOLDERS
                            FEBRUARY 20, 1998
                     

This Proxy Statement is furnished in connection with the 
solicitation of proxies by the Board of Directors of Bioject Medical 
Technologies Inc., an Oregon corporation (the "Company"), for use at 
the Company's Special Meeting of Shareholders to be held on February
20, 1998, at 1:00 p.m. (the "Meeting") and at any and all adjournments 
and postponements of the Meeting.  The Meeting will be held at the 
Company's principal executive offices at 7620 S.W. Bridgeport Road, 
Portland, Oregon for the purpose of voting on the following three proposals:
(1) the exchange of a promissory note in the original principal amount 
of $12.015 million previously issued by the Company to Elan 
International Services, Ltd. ("Elan") for approximately 832,000 shares of
the Company's Series A and Series B Convertible Preferred Stock; (2) the 
issuance of the Company's Series C Convertible Preferred Stock or 
substantially similar convertible preferred stock to fund future 
research and development of glucose monitoring technology and (3) 
the issuance of a warrant to purchase 100,000 shares of the Company's Common 
Stock to Raphael, LLC, all as more fully described in this Proxy 
Statement (collectively, the "Proposals").  For a description of the
transactions with Elan and the effects of shareholder approval of the
Proposals, see "The Elan Transactions and their Relationship to the
Proposals" and "Effects of the Proposals and Board of Directors'
Recommendation."


This Proxy Statement and the accompanying form of proxy will be
first mailed to shareholders on or about February 2, 1998.

The cost of preparing, assembling and mailing the Notice of 
Special Meeting of Shareholders, Proxy Statement and forms of proxy 
and the cost of soliciting proxies will be paid by the Company.  
Proxies may be solicited in person or by telephone, facsimile or other 
means of communication by certain of the directors, officers and 
regular employees of the Company who will not receive any additional 
compensation for such solicitation.  In addition, the Company has 
retained the services of Allen Nelson & Co. to assist in the 
solicitation of proxies.  The Company estimates it will pay Allen 
Nelson & Co. its customary and reasonable fees not expected to exceed 
$3,500, plus reimbursement of certain out-of-pocket expenses, for its 
services in soliciting proxies.  The Company will reimburse brokers or 
other persons holding stock in their names or the names of their 
nominees for the expenses of forwarding soliciting material to their 
principals.

VOTING

December 23, 1997 has been fixed as the record date for the 
determination of shareholders entitled to notice of and to vote at the 
Meeting.  On that date there were 25,368,342 shares of 
the Company's Common Stock outstanding.  The Company has previously 
authorized 10 million shares of Preferred Stock, none of which are 
issued and outstanding.  Each share of Common Stock is entitled to one vote on 
any matter that may be presented for consideration and action by the 
shareholders at the Meeting.  The holders of a majority of the shares 
of Common Stock outstanding on the record date and entitled to be 
voted at the Meeting, present in person or by proxy, will constitute a 
quorum for the transaction of business at the Meeting and any 
adjournments and postponements thereof.  Shares abstaining will be 
counted as present at the Meeting for the purpose of determining the 
presence or absence of a quorum for the transaction of business.  The 
affirmative vote of a majority of the shares of Common Stock present 
in person or by proxy and entitled to vote is required to approve each 
proposal.  Abstentions and non-votes by those present in person or by 
proxy and entitled to vote will have the same effect as votes against 
a proposal.


Each proxy will be voted according to the shareholder's 
directions specified in the proxy.  Proxies granted without voting 
instructions will be voted FOR the proposed exchange, FOR the issuance of 
Series C Convertible Preferred Stock or substantially similar 
convertible preferred stock and FOR the issuance of the warrant.  Any 
shareholder has the power to revoke his or her proxy at any time before 
it is voted at the Meeting by submitting a written notice of revocation 
to the Secretary of the Company or by filing a duly executed proxy 
bearing a later date.  A proxy will not be voted if the shareholder who 
executed it is present at the Meeting and elects to vote the shares 
represented thereby in person.

SECURITY OWNERSHIP BY PRINCIPAL SHAREHOLDERS AND MANAGEMENT


The voting securities of the Company consist of common stock 
without par value (the "Common Stock").  Each share issued at the time 
of the Record Date of December 23, 1997 carries the right to one vote 
at the Meeting.  As of December 23, 1997, a total of 25,368,342 shares of 
the Common Stock were issued and outstanding.



The following table sets forth certain information concerning the 
beneficial ownership of the Common Stock at December 17, 1997, by:  (i) 
each person known by the Company to own beneficially more than 5 
percent of the outstanding Common Stock; (ii) each of the directors and certain
executive officers; and (iii) all directors and officers as a group.  Each
shareholder listed below has sole voting and investment power with respect to
the shares beneficially owned, except as indicated:



Name of Beneficial Owner     Number of             Percentage
                               Shares             Beneficially 
                            Beneficially            Owned
                              Owned(1)

Elan International 
Services, Ltd. (2)
Flatts Smiths SL04
Bermuda                     4,477,273                 16.6%

Hambrecht & Quist (3)
50 Rowes Wharf,
Boston, Massachusetts 
02110
                            3,380,300                 12.8

Paramount Capital (4)
787 Seventh Avenue,
New York, New York  
10019
                           2,239,842                   8.4

DeSpain & Coby, Inc (5)    1,812,791                   6.8
1011 SW Emkay Dr, Ste.103
Bend, Oregon
97702

James C. O'Shea (6)          390,291                   1.5

David H. de Weese (7)         18,750                     *

Grace Keeney Fey (8)          27,250                     *

William A. Gouveia (9)       43,750                      *

Eric T. Herfindal (10)       37,500                      *

Richard J. Plestina (11)     35,000                      *

John Ruedy, MD (12)         118,200                      *

Michael Sember (13)               -                      -

Peggy J. Miller (14)        138,653                      *

J. Michael Redmond (15)     50,000                       *

All Directors and 
Executive Officers as 
a Group (11 persons) (16)    941,516                   3.6
- -------------------------
*  Less than one percent.


(1)Beneficial ownership is determined in accordance with the rules 
   word of the Securities and Exchange Commission and includes 
   shares over which the indicated beneficial owner exercises voting 
   and/or investment power.  Shares of Common Stock subject to 
   options currently exercisable or exercisable within 60 days are 
   deemed outstanding for computing the percentage ownership of the 
   person holding the options but not deemed outstanding for 
   computing the percentage of ownership of any other person.  
   Except as indicated, and subject to community property laws where 
   applicable, the persons named in the table above have sole voting 
   and investment power with respect to all shares of Common Stock 
   as shown as beneficially owned by them.

(2)Includes warrants to purchase 1,750,000 shares of Common Stock 
   which are presently exercisable.  The information regarding Elan 
   International Services, Ltd. is based on a Schedule 13D filed by 
   Elan International Services, Ltd. on October 15, 1997.

(3)Includes warrants to purchase 1,190,000 shares of Common Stock 
   which are presently exercisable.

(4)Includes warrants to purchase 1,428,571 shares of Common Stock 
   which are presently exercisable.


(5)Includes warrants to purchase 1,162,791 shares of Common Stock
   which are presently exercisable.

(6)Includes 50,000 options which became exercisable
   on October 3, 1997 and 318,750 options which are vested and 
   become exercisable on April 3, 1998.  Does not include 575,000 
   options that become vested and exercisable after 60 days.

(7)Includes options to purchase 8,750 shares of Common Stock which are
   presently exercisable. Does not include 17,500 option shares that become
   exercisable after 60 days.

(8)Includes options to purchase 26,250 shares of Common Stock which 
   are vested amd become exercisable on September 11, 1998.  Does not include
   17,500 option shares which become exercisable after 60 days.

(9)Includes options to purchase 43,750 shares of Common Stock which 
   are vested and become exercisable on September 11, 1998.  Does not include
   17,500 option shares which become exercisable after 60 days.

(10)Includes options to purchase 17,500 shares of Common Stock which 
   are presently exercisable.  Does not include 17,500 option shares 
   which become exercisable after 60 days.

(11)Includes options to purchase 8,750 shares of common stock which are      
    presently exercisable.  Does not include 26,250 option shares which 
    are exercisable after 60 days.

(12)Includes options to purchase 52,500 shares of Common Stock which 
    are vested and become exercisable on September 11, 1998.  Does not include
    17,500 option shares which become exercisable after 60 days.

(13)Does not include 17,500 option shares that become exercisable after
    60 days.  Does not include shares beneficially owned by Elan, of which
    Mr. Sember is an officer.

(14)Includes options to purchase 25,000 shares of Common Stock which 
    are vested and exercisable and options to purchase 105,000 shares 
    of Common Stock which are vested and become exercisable on 
    April 3, 1998.  Does not include 25,000 option shares which become
    exercisable after 60 days.

(15)Includes options to purchase 25,000 shares of Common Stock which 
    are vested and exercisable and options to purchase 25,000 shares 
    of Common Stock which are presently vested and become exercisable 
    on April 3, 1998.  Does not include 75,000 option shares which 
    become exercisable after 60 days.

(16)Includes 150,000 options which are presently exercisable, 512,625 
    options which are vested and become exercisable on April 3, 1998
    and 122,500 options which are vested and become exercisable 
    on September 11, 1998.  Does not include 825,000 options which become 
    vested and exercisable after 60 days.


All of the outstanding capital stock of Bioject Inc. is owned by 
the Company and 80.1 percent of the outstanding stock of Bioject JV 
Subsidiary Inc. is owned by the Company.  

THE ELAN TRANSACTIONS AND THEIR RELATIONSHIP TO THE PROPOSALS

On September 30, 1997, the Company executed a binding letter 
agreement with Elan Corporation, plc ("Elan plc") and Elan 
International Services, Ltd. ("Elan"), a wholly-owned subsidiary of 
Elan plc covering various investments in the Company by Elan, the 
formation of the Company's new subsidiary, Bioject JV Subsidiary Inc. 
("JV Sub"), and a license (the "License") by Elan plc to JV Sub of 
certain patents and know-how (the "Technology") related to systems for 
the continuous monitoring of glucose levels in persons with diabetes.  
The final documentation for the License and related transactions was 
executed on October 15, 1997. 

The parties anticipate that an ambulatory monitoring system will be 
developed under the License.  The system is expected to include a 
patch-like sensor coupled with a wrist watch-type monitoring device to 
measure glucose levels.  Human clinical trials of the system are 
presently expected to begin in early 1998. Elan plc is a worldwide drug
delivery and biopharmaceutical company with its principal research and
manufacturing facilities in Ireland, the United States and Israel.
Elan plc's shares trade on the New York, London and Dublin Stock Exchanges.


JV Sub is owned 80.1 percent by the Company and 19.9 percent by
The Company has invested $12.015 million in JV Sub's Common
Stock and Elan has invested $2.985 million in JV Sub's Common 
Stock.


Elan loaned the Company the funds the Company has invested in JV 
Sub.  The loan is evidenced by a promissory note issued by the Company 
(the "Note").  The Note bears interest from and after October 15, 1997 
at the rate of 9% until December 31, 1997 and 12% thereafter. See 
"Description of the Promissory Note".  If Proposal Number 1 is approved, 
the Note will be canceled and exchanged for the Company's Series A 
Convertible Preferred Stock and Series B Convertible Preferred Stock.
Under NASDAQ rules, the Company was barred from issuing this preferred
stock to Elan without receiving approval from the Company's shareholders.
Of the total outstanding principal and accrued interest on the Note at 
the date of exchange, $10 million plus accrued interest on the Note 
will be exchanged for Series A Convertible Preferred Stock at $15.00 
per share.  The Series A Convertible Preferred Stock will accrue 
dividends at the rate of 9% per annum (compounded semi-annually).  The 
remaining $2.015 million outstanding under the Note will be exchanged 
for Series B Convertible Preferred Stock at $15.00 per share, which will not
accrue dividends.  Depending on the market value of the Company's Common
Stock, the Series A and Series B Convertible Preferred Stock may convert at 
a 20% discount on October 15, 2004.  The value of this beneficial 
conversion feature, $3 million, will be accreted as incremental 
preferred dividends over seven years on a straight-line basis.
See "Description of the Preferred Stock".

Elan plc has agreed to conduct at its expense certain research 
and development efforts related to the Technology until the first to 
occur  of (i) commencement of human trials, (ii) April 1, 1998 or 
(iii) the devotion by Elan plc to such further research and 
development efforts of aggregate Elan plc resources equal to $2.5 
million.  Following the completion of such research efforts at Elan 
plc, the responsibility for funding the project will shift to JV Sub. Elan 
plc has agreed to make itself available to conduct other development 
and commercialization efforts as may be described for it in one or more 
development plans to be agreed in good faith by JV Sub and Elan plc.  
JV Sub will be required to pay Elan plc for such further work, but if 
the Proposal is approved by the Company's shareholders, JV Sub would 
receive a discounted price for such further work by Elan plc.  


JV Sub intends to obtain up to $5 million of the funds required 
for the further development and commercialization of the Technology  
through additional investment in JV Sub's capital stock of 
approximately $4 million by the Company and approximately $1 million 
by Elan.   The Company and Elan have indicated their intention to make 
these further investments in JV Sub, provided that JV Sub's Board of 
Directors determines that such funds are required for development of 
the Technology pursuant to a development plan which has been approved 
by Elan.   Each of the Company and Elan have reserved the right to 
withhold its share of the additional funding, but each has agreed not 
to do so unreasonably.  Elan will in any event not be obligated to 
fund any amount in excess of 25% of the amount of such additional 
investments by the Company, nor to make any further investments 
following the expiration of 30 months after the earlier of (i) 
March 15, 1998 or (ii) the date the Company's shareholders 
approve the Proposals. Provided that the Company's shareholders approve
Proposal Number 2, the Company intends to obtain up to $4 million for its
further investment in JV Sub's capital stock from the sale to Elan of Series
C Convertible Preferred Stock or similar convertible preferred stock in that
amount. Subject to certain conditions, including shareholder approval and
the use of the proceeds of the investment solely to fund such further
investments in JV Sub, the Company has the right to require Elan to purchase
such amount of the Series C Convertible Preferred Stock or similar convertible
preferred stock, at a price per share equal to ten times the average market
price of the Company's Common Stock for a ten day period prior to the date of
issuance of the Series C Convertible Preferred Stock or similar convertible
preferred stock. See "Description of the Preferred Stock".  The agreement by
Elan to purchase such Series C Convertible Preferred Stock or similar
convertible preferred stock will expire 30 months after the date the Company's
shareholders approve the Proposals.  The Company is seeking approval for the
issuance of both the Series C Convertible Preferred Stock or other similar
convertible preferred stock because if Elan purchases such preferred stock on
more than one date, the price of the preferred stock will vary requiring more
than one series of preferred stock to be issued.


The Company and JV Sub anticipate that significant levels of 
funding will be required to develop the Technology in addition to the 
funding that is described above.   The Company anticipates that 
additional funding will be raised through the future issuance of 
debt or equity by either or both of the Company and JV Sub. 


Elan has also agreed under certain conditions to loan JV Sub up to $5 million
to support the research, development and 
commercialization of the Technology after JV Sub has expended $15 million
on research and development and provided that JV Sub 
is not readily able to obtain such funds from other sources.  Such 
funding would constitute senior indebtedness of JV Sub and will bear interest
at prime rate plus 1% per annum. Elan's agreement to provide such loan is
subject to certain conditions, including the consent of Elan (which consent
shall not be unreasonably withheld or delayed), a requirement that JV Sub's
market capitalization not exceed $50 million, and the determination by 
Elan that such funding is likely to result in the commercialization of the
Technology as set forth in JV Sub's business plan.


Under the License, Elan plc has granted JV Sub an exclusive 
license to the Technology in North America for use in glucose 
monitoring.  If the Company's shareholders approve Proposals Number 1 and 2,
this will become an exclusive worldwide license to the Technology 
for such use.  The continued exclusivity of JV Sub's License is 
contingent, on a country-by-country basis, on JV Sub's refraining from 
commercializing products which would compete with the products covered 
by the licensed Elan plc Technology.  Further, the License itself is 
contingent, on a country-by-country basis, on JV Sub's diligently 
seeking and obtaining regulatory marketing approval for licensed 
products and on JV Sub's timely commercial launch of the licensed 
products in countries where such approval has been obtained. 

The Licensed Technology will include any improvements or 
modifications developed or acquired by Elan plc and useful in glucose 
monitoring applications.  JV Sub is required under the License to 
grant back to Elan plc certain nonexclusive licenses to any 
modifications or improvements made by or for JV Sub to the licensed 
Technology, for use by Elan plc in applications other than the 
monitoring of glucose levels.  If JV Sub's License becomes 
nonexclusive in certain countries, or if the License is terminated in 
certain countries (due to failure(s) to satisfy the conditions 
described above), the grant back of such licenses by JV Sub to Elan 
plc will also extend to other technology that is necessary for the 
commercialization of the licensed products by Elan plc in such 
countries, and, for such purposes. 

JV Sub will neither be permitted to assign the License nor to grant 
sublicenses to the Technology without the prior written consent of 
Elan plc. Elan plc has agreed not to withhold such consent 
unreasonably, except where the proposed assignee or sublicensee is one 
of a number of specified companies seen as actual or potential 
competitors.


The term of the License is 15 years, or on a country by country basis for the
life of the last patent to expire, whichever is longer. In the event that 
15% of JV Sub's equity is acquired by any one of a number
of specified companies identified by Elan plc as actual or potential
competitors, or any other entity to which Elan plc does not consent (which
consent shall not be unreasonably withheld in the case of such other,
unspecified companies), the License may be immediately terminated 
at the option of Elan plc.



JV Sub has paid Elan plc an initial royalty of $15 million 
under the License.  In addition, JV Sub is required under the 
License to pay Elan plc an aggregate of $15.5 million in further royalties 
as the following milestones are acheived:  $1 million within 10 days of the
commencement of pivotal clinical trials; $1.5 within 120 days of the
successful completion of the clinical trials; $3 million within 10 days of
the initial regulatory filing to obtain marketing approval; and $10 million
within 120 days of the grant of U.S. marketing approval for the first product.
If the Company's shareholders approve Proposals Number 1 and 2 described herein,
thereby extending the territory of the License to be worldwide, the royalty 
payment called for upon the grant of US marketing approval will be 
split into two payments of $5 million each, one to be paid upon the grant of
such US marketing approval and the other to be paid upon the grant of
marketing approval in any other of certain major nations listed.
Additionally, JV Sub will be required under the License to pay Elan plc a
continuing royalty equal to a percentage of the net revenues from sublicenses
of the Technology or from the sale by JV Sub or its sublicensees of products
covered by the licensed patents or that incorporate or apply the licensed
know-how.  The percentage royalty will increase in stages as the aggregate 
net revenues in a given fiscal year exceed stated levels.  These 
stated levels will be higher if the Company's shareholders approve 
Proposals Number 1 and 2 described herein, reflecting the larger potential
market for such products under the License once its territory has been
expanded to be worldwide.   



Elan has invested $3.0 million in the Company in exchange for 
2,727,273 shares of the Company's Common Stock and a five-year warrant 
to purchase an additional 1,750,000 shares of Common Stock at $2.50 
per share. The purchase price of the Company's Common Stock and the exercise
price of the warrant were determined by arms-length negotiation with Elan.  The
Company has agreed that it will use its best efforts to cause a nominee of
Elan to be elected to its Board of Directors for as long as Elan owns at
least a five percent equity position in the Company (this level will increase
to ten percent in seven years).  The Company's Board of Directors added
Michael Sember, Elan's vice president of planning, investment and development,
as a director effective October 16, 1997, the day following the closing of
the transactions contemplated by the letter agreement.  


Elan has agreed that for a period of three years it will not (i) 
purchase shares or assets of the Company from third parties, (ii) 
participate in a tender or exchange offer, merger or other business 
acquisition involving the Company, (iii) participate in any 
recapitalization, restructuring, liquidation, dissolution or other 
extraordinary transaction with respect to the Company, (iv) solicit 
proxies or consents to vote any voting securities of the Company, (v) 
attempt to influence management or control of the Company or (vi) 
change the composition of the Company's Board of Directors; provided 
that such agreement will not apply if a tender offer or a proxy 
solicitation with respect to an acquisition proposal is made by a 
party which has been invited in writing by the Company or is 
unaffiliated with Elan.


Elan has also agreed to fund $500,000 of development expenses for 
the development of pre-filled ampules for the Company's 
needle-free injection technology.  The funding will commence 
in the first quarter of 1998, upon written request from the 
Company, in the form of grants to the Company in four, quarterly 
(in arrears) payments of $125,000 each.


For its services in connection with the transactions described 
above and the introduction of the Company to Elan, Raphael, LLC, a 
management consulting company, has received a cash payment in the 
amount of $150,000 and, subject to shareholder approval of
Proposal Number 3, will receive a five-year warrant to purchase 100,000
shares of the Company's Common Stock at an exercise price of $0.85 per share.
If shareholder approval is not received, Raphael, LLC, will receive an 
additional cash payment totalling $75,000 payable immediately after the
shareholder vote.


As discussed above, Elan has recently purchased 2,727,273 shares 
of the Company's Common Stock.  These shares represent 10.8% of 
all shares of Common Stock outstanding on the date of record and are 
entitled to vote on the proposals.  If the proposal to exchange 
the Note plus accrued interest for convertible preferred stock is 
approved and assuming immediate conversion of the preferred stock 
by Elan at the stated conversion rate, Elan would hold 
approximately 11 million shares of Common Stock or approximately 
30% of total voting shares outstanding.  If the Company's 
shareholders do not approve the preferred stock transactions with 
Elan, the Company would seek to sell equity securities in private 
placements or public offerings to repay the debt due to Elan and 
to finance future JV Sub research and development and other 
expenses.  The Company is not engaged in any discussions or 
negotiations with third parties in connection with any such 
financing and there can be no assurance that such financing could 
be obtained in a timely manner, on favorable terms or at all.


 A pro forma balance sheet at September 30, 1997, reflecting (i) the $3.0
million investment by Elan in the Company, (ii) the cancellation of the Note
in exchange for Series A and Series B Convertible Preferred Stock of the
Company, and (iii) the issuance of Series C Convertible Preferred Stock or
other similar convertible preferred stock of the Company to fund JV Sub
research and development, is attached hereto as Appendix A.  


DESCRIPTION OF THE PROMISSORY NOTE

On October 15, 1997, Elan loaned the Company the sum of $12.015 
million in exchange for a promissory note (the "Note") issued by the 
Company, bearing interest at the rate of 9% per annum from October 15, 
1997 through December 31, 1997, and at a rate of 12% per 
annum thereafter, with interest payable on April 13, 1998; thereafter 
interest is payable quarterly in arrears.  All principal and accrued 
interest owing on the Note shall become due and payable on October 
15, 2001, unless prepaid at the Company's option at any time on or 
after February 1, 1998.  

The Note and the Securities Purchase Agreement, pursuant to which 
the Note is issued, contain covenants restricting certain activities of the 
Company.  While the Promissory Note remains outstanding, the Company 
may not without Elan's written consent (a) incur any indebtedness or 
liens outside the ordinary course of business, which ordinary course 
shall include equipment liens and working capital lines up to a maximum 
of the lesser of $5 million and 50% of the Company's aggregate 
consolidated accounts receivable and inventory, (b) acquire or dispose 
of any material business or assets outside the ordinary course of 
business, or (c) effect any merger, consolidation or acquire control 
or any other corporation or business entity.  Elan has agreed that 
its consent, if sought, will not be unreasonably withheld or delayed. 

DESCRIPTION OF THE PREFERRED STOCK

Series A Convertible Preferred Stock

Dividends.  The Series A Convertible Preferred Stock ("Series A 
Convertible Preferred Stock") accrues a mandatory dividend of 9% per 
annum, compounded semi-annually, which shall be paid by issuance of 
additional shares of Series A Convertible Preferred Stock.


Liquidation Preference.  Upon any liquidation, dissolution or
winding up of the Company and prior to any distributions to holders of
Common Stock, each holder of Series A Convertible
Preferred Stock shall be entitled to receive $15.00 (the original 
issuance price) plus accrued and unpaid dividends thereon, per share.


Optional Conversion.  Prior to October 15, 2004, each original issue share of
the Series A Convertible Preferred Stock is convertible at Elan's election
into ten shares of Common Stock.  This conversion ratio is subject to
anti-dilution adjustments for (a) so-called mechanical adjustments in the case
of stock splits, recapitalizations or similar events or (b) for issuances (or 
in the case of options, grants thereof) to affiliates of the 
Company or the Company's or such affiliates' respective directors, 
officers, employees or agents, at prices below the 
then-market price other than shares (or options to acquire shares) 
up to 3,650,000 shares of Common Stock issued to directors,
officers or employees of the Company or its affiliates (or 
in the case of options, granted at an exercise price) at less 
than market value under a duly-enacted stock option or 
compensation plan (the anti-dilution adjustments 
described above, the "Anti-dilution Adjustments").  In the event of such
Optional Conversion, Elan forfeits any accrued and unpaid dividends.

Optional Redemption. The Company has the right to redeem up to one-third
of the Series A Convertible Preferred Stock after three years, together 
with one-third of the then-accrued and unpaid dividends, provided that the
market price of the Company's Common Stock reaches and remains at $2.25 per
share or greater during the 30-day period prior to the proposed redemption
date.  Subject to the same condition as to the market
price of the Common Stock, an additional one-third of the originally issued
Series A Convertible Preferred Stock may be redeemed by the Company after
four years, together with one-half of then-accrued and unpaid dividends (if 
the first third was previously redeemed, or else two-thirds of the 
accrued and unpaid dividends if not).  The balance of the Series 
A Convertible Preferred Stock may be redeemed by the Company 
after five years, together with the remaining accrued and unpaid 
dividends, again, subject to the same condition that the Common 
Stock reaches and remains at $2.25 per share or greater during 
the 30-day period prior to the proposed redemption date.  Any 
such redemptions by the Company would be effected by the 
Company's giving between 45 days' and 90 days' notice and 
paying the original issuance price of $15.00 per share, plus such 
portions of the accrued dividends.  During such notice period, 
Elan retains the right to convert the Series A Convertible 
Preferred Stock (or the applicable portion thereof) in accordance 
with its terms.  The Series A Convertible Preferred Stock may be 
redeemed by the Company prior to such three, four or five-year 
periods, as applicable, only in the event that the Company shall 
have reasonably determined, in good faith, after consultation with 
Elan, to permanently abandon development of the Technology or products based on
the Technology.  Any such redemption would require the payment 
by the Company of the original issue price and all accrued dividends, 
and a similar 45 to 90-day notice period would be required, during 
which Elan similarly retains the right to convert the Series A 
Convertible Preferred Stock (or the applicable portion thereof) in 
accordance with its terms.  

Mandatory Conversion. As of October 15, 2004, each share of 
Series A Convertible Preferred Stock not previously converted or 
redeemed shall automatically convert into that number of shares of Common Stock
determined by dividing the sum of the original issuance price of 
$15.00 and accrued but unpaid dividends by a per share Common 
Stock price equal to 80% of the average of the closing prices of 
the Common Stock for the 10 trading days ending on October 
13, 2004; provided, that if the average of such closing prices is 
greater than or equal to $1.80, such per share price shall be $1.50.


Other Covenants.  The Series A Convertible Preferred Stock contains
covenants restricting the Company's ability to take certain actions
affecting the Series C Convertible Preferred Stock without the
prior written consent or affirmative vote of a majority in interest
of the Series A Convertible Preferred Stock.  Such covenants
specifically restrict the Company's ability to (i) amend or repeal
any provision of, or add any provision to, the Company's Articles of
Incorporation or Bylaws if such action would adversely alter the 
preferences, rights, privileges or powers of, or the restrictions 
provided by the terms of the Series A Convertible Preferred Stock 
for the benefit of, the Series A Convertible Preferred Stock, (ii) 
create a series of Preferred Stock with a liquidation preference senior 
to the Series A Convertible Preferred Stock, (iii) effect
any merger, consolidation or similar transaction, or (iv) increase
or decrease the number of authorized shares of Series A Convertible 
Preferred Stock, except as required by the terms of the Series
A Convertible Preferred Stock.


While the Series A or B Convertible Preferred Stock is issued and 
outstanding, the Securities Purchase Agreement contains covenants 
limiting the Company's ability (i) to acquire or dispose of any 
material business or assets outside the ordinary course of business, 
and (ii) to incur indebtedness in excess of $10 million aggregate 
principal amount unless the Company can reasonably establish (based on 
prudent and customary commercial practices and standards in the 
capital markets) that the Company may incur such indebtedness from an 
institutional lender, venture capital firm or reputable "hedge" fund 
on a prudent and reasonable basis, based on the Company's then credit-
worthiness, prospects, solvency and business, in each case, without 
the prior written consent of Elan which consent shall not be 
unreasonably withheld or delayed. Notwithstanding the foregoing, the 
Company may incur working capital lines and equipment leases from 
unaffiliated third parties in bona fide financing transactions in 
principal amounts up to the lesser of $5 million and 50% of the 
Company's aggregate consolidated accounts receivable and inventory.

However, if Elan has reasonably withheld its consent to any 
of the foregoing transactions, the Company may nevertheless 
effect such a transaction if it redeems the Series A Convertible 
Preferred Stock, effective at the closing of such transaction 
by paying to Elan the entire original issuance price of $15.00 
per share plus all then accrued and unpaid dividends, together 
with the issuance to Elan of a warrant (which shall be 
non-transferable, other than to Elan affiliates, or no more 
than five non-affiliates) and which shall entitle Elan to 
purchase that number of shares of the securities of the Company 
into which the Series A Convertible Preferred Stock would 
have been convertible had it not been redeemed under this
provision.  Such warrant would be exercisable until October 
15, 2004, at an exercise price equal to the sums paid in 
redemption of the Series A Convertible Preferred Stock, 
plus 9% per annum from the redemption date to the exercise date.

Series B Convertible Preferred Stock

Dividends. The Series B Convertible Preferred Stock ("Series B 
Convertible Preferred Stock") participates with the Common Stock on any 
declared or paid dividends or distributions, but has no mandatory dividend
provisions. 


Liquidation Preference.  Upon any liquidation, dissolution or 
winding up of the Company and prior to any distributions to holders of
Common Stock, each holder of Series B Convertible
Preferred Stock shall be entitled to receive $15.00 (the original issuance 
price) per share plus any accrued and unpaid dividends thereon.

Optional Conversion.  Prior to October 15, 2004, each original issue share of
the Series B Convertible Preferred Stock is convertible into ten shares of
Common Stock, subject to the Anti-dilution Adjustments, identical to those for
Series A Convertible Preferred Stock.

Optional Redemption.  The Series B Convertible Preferred Stock is redeemable
upon the same terms as the Series A Convertible Preferred Stock. 

Mandatory Conversion. As of October 15, 2004, each share of 
Series B Convertible Preferred Stock not previously converted or 
redeemed shall automatically convert into that number of shares of Common Stock
determined by dividing the sum of the original issuance price of 
$15.00 and accrued but unpaid dividends by a price equal to 80% of the 
average of the closing prices of the Common Stock for the 10 trading 
days ending on the October 13, 2004; provided, that if the average of 
such closing prices is greater than or equal to $1.80, such price 
shall be equal to $1.50.

Series C Convertible Preferred Stock

Dividends.  The Series C Convertible Preferred Stock ("Series C 
Convertible Preferred Stock") participates with the Common Stock on any 
declared or paid dividends or distributions, but has no mandatory dividends. 


Liquidation Preference.  Upon any liquidation, dissolution or 
winding up of the Company and prior to any distributions to holders of
Common Stock, each holder of Series C Convertible Preferred Stock shall be
entitled to receive the original issuance price of the Series C Convertible
Preferred Stock per share plus any accrued and unpaid dividends theron.  The
original issuance price of the Series C Convertible Preferred Stock shall be
based on the market price of the Common Stock at the time of issuance.


Optional Conversion.  Prior to October 15, 2004, each original issue share of
the Series C Convertible Preferred Stock is convertible into ten shares of
Common Stock, subject to the Anti-dilution Adjustments, identical to those for
Series A Convertible Preferred Stock.

Optional Redemption.  The Series C Convertible Preferred Stock is redeemable 
upon the same terms as the Series A Convertible Preferred Stock, except that
the redemption price per share shall be the original issuance price plus any
accrued and unpaid dividends.

Mandatory Conversion. As of October 15, 2004, each share of 
Series C Convertible Preferred Stock not previously converted or 
redeemed shall automatically convert into that number of shares of Common Stock 
determined by dividing the sum of the original issuance price and 
accrued but unpaid dividends by a price equal to one-tenth of the 
original issuance price.

The proposed terms of the Series A Convertible Preferred Stock, Series B
Convertible Preferred Stock, and Series C Convertible Preferred Stock, which
are subject to adjustment prior to issuance, have been filed as an exhibit
to the Company's current report on Form 8-K/A filed on November 14, 1997.

                              PROPOSAL NUMBER 1:

    APPROVAL OF THE EXCHANGE OF A PROMISSORY NOTE FOR SERIES A AND
               SERIES B CONVERTIBLE PREFERRED STOCK

DESCRIPTION OF AND REASON FOR THE PROPOSAL

As described in more detail above under the heading "The Elan 
Transactions and Their Relationship to the Proposals," Proposal 
Number 1 seeks approval of the exchange of an outstanding 
promissory note to Elan in the amount of $12.015 million plus 
accrued interest for approximately 698,000 shares of Series A 
Convertible Preferred Stock and approximately 134,000 shares of  Series B 
Convertible Preferred Stock.


Under governing Oregon corporate law and the Company's Articles 
of Incorporation and Bylaws, no action or authorization by the 
Company's shareholders is necessary prior to the issuance of 
additional securities of the Company of a class authorized in the 
Company's Articles of Incorporation (including the Series A, B 
and C Convertible Preferred Stock).  However, because 
transactions in the Company's Common Stock are reported on the 
National Association of Securities Dealers Automated Quotation 
("Nasdaq") National Market System, the Company is subject to 
certain requirements of the National Association of Securities 
Dealers.  The sale to Elan of 2,727,273 shares of Common Stock 
and a five year warrant to purchase an additional 1,750,000 shares of 
Common Stock substantially exhausted the number of shares that 
could be issued by the Company in the absence of shareholder 
approval.  Accordingly, Nasdaq rules require the Company to seek shareholder 
approval of the issuance by the Company of the Convertible 
Preferred Stock described above under the heading "Description of 
the Proposals."


Approval of Proposal Number 1 would eliminate the Company's 
obligation to make future cash interest payments or repayment of 
the principal amount to Elan under the Note.  If shareholder 
approval of the Proposal is not obtained, the Company could be 
subject to delisting from Nasdaq, due to Nasdaq's requirement 
that a listed company maintain total net assets of at least $4 
million.  While the Note remains outstanding, the Company's net 
assets will remain below this minimum. If shareholder approval of 
the exchange is not obtained, the Company would seek to take 
other actions to maintain listing eligibility, but there can be 
no assurance that the Company would be successful in such efforts 
or would otherwise be able to maintain the listing requirements.

Approval of the exchange also would lead to the likely issuance, 
upon conversion of the preferred stock to Common Stock, of Common 
Stock at a deemed conversion price less than the future market 
price of the Common Stock, as it is presumed that Elan would not 
convert its shares voluntarily if the deemed conversion price 
were not less than the market price of the Common Stock.  Also, 
mandatory conversion occurs at a discount to market price of the 
Common Stock on the date of conversion.  See "Description of the 
Preferred Stock - Mandatory Conversion."  

Holders of the preferred stock will be entitled to receive 
distributions on a liquidation in preference to the claims of the 
holders of the Common Stock in amounts equal to the original 
liquidation preference of Series A and Series B Convertible 
Preferred Stock.  The issuance of the Series A and B Convertible 
Preferred Stock will dilute the interest of each shareholder in 
the economic results of the Company pro rata based on the number 
of shares owned by existing shareholders prior to any issuance.  
Certain corporate actions will require approval of the holders of 
preferred stock.  See "Description of the Preferred Stock."

SUMMARY EFFECTS OF PROPOSAL NUMBER 1 AND BOARD OF DIRECTORS 
RECOMMENDATION

As described in more detail above and under the heading "The 
Elan Transactions and Their Relationship to the Proposals," 
approval of Proposal Number 1 will have several effects for the 
Company and JV Sub.  Approval of Proposal Number 1 will:

- -effect the automatic exchange of the Note for the Series A and 
 Series B Convertible Preferred Stock, thereby eliminating the 
 Company's requirement to make accrued or future cash interest payments to 
 Elan under the Note or to repay the Note with cash

- -permit holders of preferred stock to receive distributions upon 
 liquidation in preference to the holders of Common Stock

- -permit conversion of the preferred stock into Common Stock
 at deemed conversion prices which are likely to be less than future market 
 prices of the Common Stock

- -allow issuance of the preferred stock which will dilute the interest of each
 current shareholder in the economic results of the Company

- -eliminate the Note, which had reduced the Company's net assets below the
 minimum requirements for listing on Nasdaq

- -expand the territory under the License from North America to
 world-wide (if Proposal Number 2 is also approved)

- -reduce the cost to JV Sub of certain research and development
 work that may be conducted by Elan plc at the request of JV Sub 
 (if Proposal Number 2 is also approved)

- -split the contingent royalty payment triggered by FDA approval
 into two stages, one upon FDA regulatory approval and the other 
 upon regulatory approval outside the United States (if Proposal 
 Number 2 is also approved)

- -reduce the royalty payments for incrementally higher levels of
 net sales, reflecting the larger potential market under a world-
 wide license (if Proposal Number 2 is also approved)

The Board of Directors recommends that the shareholders vote FOR 
Proposal Number 1 to approve the exchange of the Note to Elan for 
Series A and Series B Convertible Preferred Stock.


                          PROPOSAL NUMBER 2:

              APPROVAL OF THE FUTURE ISSUANCE OF SERIES C CONVERTIBLE
                   PREFERRED STOCK OR OTHER SIMILAR CONVERTIBLE
                               PREFERRED STOCK TO ELAN

DESCRIPTION OF AND REASON FOR THE PROPOSAL


As more fully detailed above under the heading "The Elan 
Transactions and Their Relationship to the Proposals," Proposal 
Number 2 seeks approval of the future issuance and sale of Series 
C Convertible Preferred Stock or other similar convertible preferred stock
for an aggregate purchase price of up to $4 million, in order to fund the
Company's portion of certain research and development costs of JV Sub.  As is
the case with Proposal No. 1, shareholder approval is necessary due to the 
requirements of Nasdaq and not pursuant to either Oregon 
corporate law or the Company's Articles of Incorporation and 
Bylaws.  


Approval of Proposal Number 2 would provide the Company with the 
option to fulfill its financing commitments to JV Sub by selling 
other Preferred Stock with similar terms to Elan.  Approval also 
would expand the territory under the License from North America 
to be world-wide, and would reduce the cost to JV Sub of certain 
research and development work that may be conducted by Elan plc 
at the request of JV Sub, as detailed above under the heading 
"Description of the Proposals."  Under the License, JV Sub will 
be obligated to pay certain royalties to Elan upon 
obtaining FDA regulatory approval of an ambulatory glucose 
monitoring system.  If shareholders approve Proposal Number 2, 
with the result that the territory under the License is world-
wide, such royalty payment will be split into two payments, one 
upon FDA regulatory approval and the other upon regulatory 
approval outside the United States.  Should shareholder approval 
not be obtained, an amount equal to the two combined royalty 
payments will be payable to Elan in one payment when regulatory 
approval in the United States is received.  Shareholder approval 
also would reduce the royalty payments for incrementally higher 
levels of net sales, reflecting the larger potential market under 
a world-wide License.  Thus, if and when JV Sub markets a 
product, having obtained for it all necessary regulatory 
approval, the royalty payments due Elan will be lower at higher 
levels of net sales, thereby allowing JV Sub to retain a larger 
percentage of any sales proceeds.

As with Proposal Number 1, holders of the preferred stock will be 
entitled to distributions upon liquidation in preference to the 
claims of the holders of the Common Stock.  The issuance of the 
Series C Convertible Preferred Stock will dilute the interest of 
each shareholder in the economic results of the Company pro rata 
based on the number of shares owned by existing shareholders 
prior to any issuance.  Certain corporate actions will require 
approval of the holders of preferred stock.  See "Description of 
the Preferred Stock."  The Company does not have the right to 
sell Series C Preferred Stock to Elan unless it issues Series A 
and Series B Convertible Preferred Stock to Elan in exchange for 
the Note.  Accordingly, Proposal 2 will not be submitted for a 
vote at the meeting if Proposal 1 is not approved.

SUMMARY EFFECTS OF PROPOSAL NUMBER 2 AND BOARD OF DIRECTORS 
RECOMMENDATION

As described in more detail above and under the heading "The 
Elan Transactions and Their Relationship to the Proposals," 
approval of Proposal Number 2 will have several effects for the 
Company and JV Sub.  Approval of Proposal Number 2 will:

- -provide the Company with the option to fulfill its financing 
 commitments to JV Sub by selling Series C Convertible Preferred 
 Stock or other similar convertible preferred stock to Elan


- -permit holders of preferred stock to receive distributions upon
 liquidation in preference to the holders of Common Stock

- -permit conversion of the preferred stock into common stock at deemed
 conversion prices which are likely to be less than future market prices of
 the Common Stock

- -allow issuance of the preferred stock which will dilute the interest of each
 current shareholder in the economic results of the Company

- -expand the territory under the License from North America to
 world-wide (if Proposal Number 1 is also approved)

- -reduce the cost to JV Sub of certain research and development
 work that may be conducted by Elan plc at the request of JV Sub 
 (if Proposal Number 1 is also approved)

- -split the contingent royalty payment triggered by FDA approval
 into two stages, one upon FDA regulatory approval and the other 
 upon regulatory approval outside the United States (if Proposal 
 Number 1 is also approved)

- -reduce the royalty payments for incrementally higher levels of
 net sales, reflecting the larger potential market under a world-
 wide license (if Proposal Number 1 is also approved)

The Board of Directors recommends that the shareholders vote FOR 
Proposal Number 2 to approve the issuance and sale of Series C 
Convertible Preferred Stock to Elan.


                         PROPOSAL NUMBER 3:

              APPROVAL OF THE ISSUANCE OF A WARRANT TO PURCHASE
                        100,000 SHARES OF COMMON STOCK

DESCRIPTION OF AND REASON FOR THE PROPOSAL

Proposal Number 3 seeks approval of the issuance of a five-year 
warrant to purchase 100,000 shares of Common Stock at $0.85 per 
share to Raphael, LLC, a management consulting company, as part of 
its fee for introducing the Company to Elan.  As with the other 
proposals, Nasdaq rules require the Company to seek shareholder 
approval of the issuance by the Company of the warrant.  Approval 
of the proposal would eliminate the additional cash payment in 
the amount of $75,000 to Raphael, LLC, for consulting services, 
which would be otherwise owed to Raphael, LLC, in lieu of the
warrant, and will be paid to Raphael, LLC, immediately after the 
Special Meeting should Proposal Number 3 not obtain shareholder 
approval.  However, approval of Proposal Number 3 would afford 
Raphael LLC the possibility of realizing significantly greater 
value if the market price of the Common Stock increases in the 
future.

SUMMARY EFFECTS OF PROPOSAL NUMBER 3 AND BOARD OF DIRECTORS 
RECOMMENDATION

Approval of Proposal Number 3 will eliminate the additional cash 
payment of $75,000 to Raphael, LLC, for consulting services, 
which would be owed to Raphael, LLC, in lieu of the warrant.

The Board of Directors recommends that the shareholders vote FOR 
Proposal Number 3 to approve the issuance of a warrant to 
purchase Common Stock.


INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE

The following documents, which have been filed by the Company 
with the Commission, are incorporated herein by reference:

1. Comparative audited consolidated financial statements of 
   the Company, including the notes thereto, for the year ended March 
   31, 1997, together with the Auditors' Report thereon 
   (Incorporated by reference to the Company's Annual Report on 
   Form 10-K for the year ended March 31, 1997, as amended by Form 10-K/A
   filed on July 29, 1997, August 20, 1997 and January 22, 1998).



2. Management's Discussion and Analysis of Financial 
   Conditions and Results of Operations contained in the Company's  Annual 
   Report on Form 10-K for the year ended March 31, 1997 (Incorporated by 
   reference to the Company's Annual Report on Form 10-K for the 
   year ended March 31, 1997 as amended by Form 10-K/A
   filed on July 29, 1997, August 20, 1997 and January 22, 1998).



3. Comparative unaudited consolidated interim financial 
   statements of the Company for the six months ended September 
   30, 1997 (Incorporated by reference to the Company's Quarterly 
   Report on Form 10-Q for the period ended September 30, 1997 as amended
   by Form 10-Q/A filed on January 22, 1998).



4. Management's Discussion and Analysis of Financial 
   Conditions and Results of Operations contained in the Company's Quarterly 
   Report on Form 10-Q for the period ended September 30, 1997 
   (Incorporated by reference to the Company's Quarterly Report on 
   Form 10-Q for the period ended September 30, 1997 as amended by Form 10-Q/A
   filed on January 22, 1998).


Any statement contained in a document incorporated by reference herein shall
be deemed to be modified or superseded for purposes of this Proxy Statement
to the extent that a statement contained herein or in any other subsequently
filed document which also is incorporated by reference
herein modifies or supersedes such statement.  Any statement so modified or 
superseded shall not be deemed, except as so modified or superseded, 
to constitute a part of this Proxy Statement.  

Arthur Andersen, LLP, independent public accountants, 
examined the financial statements of the Company for fiscal 1997.
The Company expects representatives of Arthur Andersen, LLP, to be present at 
the Meeting and to be available to respond to appropriate questions from
shareholders.  The accountants will have the opportunity to make a statement
at the Meeting if they desire to do so.

OTHER MATTERS

The Board of Directors of the Company does not know of any other 
matters that are to be presented for action at the Meeting.  Should 
any other matters come before the Meeting or any adjournments and 
postponements thereof, the persons named in the enclosed proxy will 
have the authority to vote all proxies received with respect to such 
matters in their discretion.

                         By Order of the Board
                             Of Directors,



                             /s/ Peggy J. Miller
                             Peggy J. Miller
                             Vice President,
                             Chief Financial Officer 
                             and Secretary/Treasurer


Portland, Oregon
January 28, 1998


                                                         APPENDIX A
  
                 BIOJECT MEDICAL TECHNOLOGIES INC.
            Pro forma Consolidated Condensed Balance Sheet
                      September 30, 1997

The following sets forth the pro forma effects of the
following transactions on the consolidated condensed balance sheet of the
Company as if the transactions had been completed as of September 30, 1997:
(a) sale of Common Stock and warrants by the Company to Elan completed on
October 15, 1997, (b) exchange of a $12.015 million promissory note held by
Elan for Series A and Series B Convertible Preferred Stock of the Company,
which will be effected if Proposal Number 1 is approved, and (c) sale of
$4.0 million of Series C Convertible Preferred Stock or other similar preferred
stock of the Company to Elan, which the Company will, subject to certain
conditions, have the right to cause Elan to purchase if Proposal Number 2 is
also approved. Pro forma income statements have not been presented as the
Company believes that such statements would not be material to a shareholder's
voting decision.



<TABLE>
<CAPTION>

                  Actual  Adjustment (a)  Pro forma  Adjustment (b)  Pro forma  Adjustment (c) Pro forma
<S>                <C>       <C>            <C>        <C>             <C>          <C>           <C>

(in thousands of $)
ASSETS

Current assets:

Cash and
     Marketable
     Securities  $ 1,218   $ 2,800        $ 4,018   $     -         $ 4,018    $   -         $ 4,018

Accounts
     Receivable     536          -            536         -             536        -             536

Inventories       1,359          -          1,359         -           1,359        -           1,359

Other current
     Assets          64          -             64         -              64        -              64
                  -----      -----          -----     -----           -----    -----           -----                   
                  3,177      2,800          5,977         -           5,977        -           5,977            
                  -----      -----          -----     -----           -----    -----           -----

Cash-restricted

Property &
 equipment, net   2,648          -          2,648         -           2,648        -           2,648

Other assets, net   330          -            330         -             330        -             330
                  -----      -----          -----      ----           -----    -----          ------
                $ 6,155    $ 2,800        $ 8,955     $   _        $  8,955  $ 4,000        $ 12,955        
                  -----      -----          -----      ----           -----    -----          ------
LIABILITIES 
AND EQUITY

Current 
liabilities:

Accounts
     Payable   $   654     $     -         $  654      $   -       $    654   $    -        $    654      

Other current  
      Liabilities  476           -            476          -            476         -             476
                 -----       -----          -----       ----          -----      ----           -----
                 1,130           -          1,130          -          1,130         -           1,130
                 -----       -----          -----       ----          -----      ----           -----            

Long-term Debt  12,015           -         12,015     (12,015)            -                         -

Shareholders'
equity:

Convertible 
preferred stock-
   Series A                                             7,500         7,500                      7,500
   Series B                                             1,515         1,515                      1,515
   Series C                                                                     4,000            4,000

Common stock    41,281       2,800         44,081       3,000        47,081                     47,081

Accum deficit  (48,271)          -        (48,271)          -       (48,271)        -          (48,271)
                ------       -----         ------      ------        ------     -----           ------

Net equity      (6,990)      2,800         (4,190)     12,015         7,825     4,000           11,825
                -------      -----          -----      ------         -----     -----           ------   
               $ 6,155     $ 2,800         $ 8,955   $      -       $ 8,955   $ 4,000         $ 12,955
                 -----       -----           -----     ------         -----     -----           ------

</TABLE>

    

(a) Adjustment reflects receipt of net proceeds from the private placement with
Elan of approximately 2.7 million shares of common stock and a five year
warrant to purchase 1.75 million shares of common stock at $2.50 per share,
assuming no exercise of the warrants. This transaction was completed in
October 1997 and is not subject to shareholder approval.



(b) Reflects the conversion of a $12.015 million promissory note to Elan in
exchange for Series A and Series B Convertible Preferred Stock of the Company.
The allocation of $3.0 million to common stock reflects the inherent dividend
to Elan as a result of certain conversion terms which in some instances permit
a discount to market on conversion and will be accreted over the seven year
period the convertible preferred stock may be outstanding.



(c) Reflects receipt of $4.0 million from Elan as a result of the issuance of
Series C Convertible Preferred Stock or other similar convertible preferred
stock of the Company to fund research and development of JV Sub.  Such
proceeds, if and when raised, must be invested in JV Sub and used to fund
further development and commercialization of the glucose monitoring technology
licensed from Elan.



The above unaudited pro forma consolidated condensed balance sheet is presented
to assist the reader in analyzing the effects of the proposed transactions
contained in the accompanying Proxy Statement.  This unaudited pro forma
balance sheet does not include all information and footnote disclosures
normally included in audited financial statements.  However, in the opinion of
management, all adjustments (which include only normal, recurring adjustments
except as described above) necessary to present fairly the financial position
have been made.  It is suggested that this unaudited pro forma balance sheet
be read in conjunction with the financial statements included in the Company's
Annual Report on Form 10-K for the year ended March 31, 1997.



<PAGE>

                              NOTICE OF
                     SPECIAL SHAREHOLDERS' MEETING
                                 AND
                           PROXY STATEMENT
                      ___________________________
                            
                          FEBRUARY 20, 1998
                         
                          PORTLAND, OREGON

                               BIOJECT

<PAGE>

SHAREHOLDERS ARE URGED TO SPECIFY THEIR CHOICES ON, DATE, SIGN AND 
RETURN THE ENCLOSED PROXY IN THE ENCLOSED ENVELOPE.  PROMPT RESPONSE 
IS HELPFUL, AND YOUR COOPERATION WILL BE APPRECIATED.


              BIOJECT MEDICAL TECHNOLOGIES INC.
       THE SPECIAL MEETING OF SHAREHOLDERS, FEBRUARY 20, 1998
     THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS



The undersigned hereby appoints James C. O'Shea and Peggy J.
Miller, and each of them, as proxies, with full power of substitution 
in each of them, to vote for and on behalf of the undersigned at the 
Special Meeting of Shareholders of the Company to be held on February 
20, 1998 and at any adjournment thereof, upon matters properly coming 
before the meeting, as set forth in the related Notice of Meeting and Proxy 
Statement, both of which have been received by the undersigned.  
Without otherwise limiting the general authorization given hereby, 
said proxies are instructed to vote as indicated on the reverse side.



1.  Approve the exchange of a promissory note in the original 
    principal amount of $12.015 million issued by the Company to Elan for 
    approximately 832,000 shares of the Company's Series A and Series B 
    Convertible Preferred Stock,

                 [ ] FOR  [ ] AGAINST  [ ] ABSTAIN

2.  Approve the issuance of the Company's Series C Convertible Preferred Stock
    or other similar convertible preferred stock to Elan in connection with
    future funding of glucose monitoring research and development

                     [ ] FOR  [ ] AGAINST  [ ] ABSTAIN

3.  Approve the issuance to Raphael, LLC, of a warrant to purchase 100,000
    shares of the Company's Common Stock.

                 [ ] FOR  [ ] AGAINST  [ ] ABSTAIN

2.  To take action upon any other business as may properly come 
    before the meeting.

UNLESS OTHERWISE SPECIFIED, THIS PROXY WILL BE VOTED "FOR" THE PROPOSAL
AND WILL BE VOTED IN THE DISCRETION OF THE PROXIES ON SUCH MATTERS AS 
MAY PROPERLY COME BEFORE THE MEETING.


Please sign, date and mail your proxy today.

Signature:____________________________   Date:___________________

Signature:____________________________   Date:___________________
            (if held jointly)

Capacity:___________________________________________
          (Title or Authority eg. Executor, Trustee)




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