WARNING: THE EDGAR SYSTEM ENCOUNTERED ERROR(S) WHILE PROCESSING THIS SCHEDULE.
<TABLE> <S> <C>
<ARTICLE> 6
<CIK> 0000810271
<NAME> SB Growth & Income Fund
<SERIES>
<NUMBER> 003
<NAME>Smith Barney Investment Series
<S> <C>
<PERIOD-TYPE> Year
<FISCAL-YEAR-END> Oct-31-2001
<PERIOD-END> Oct-31-2000
<INVESTMENTS-AT-COST> 1,215,777,189
<INVESTMENTS-AT-VALUE> 1,482,363,866
<RECEIVABLES> 18,939,102
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<OTHER-ITEMS-ASSETS> 0
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<PAYABLE-FOR-SECURITIES> 32,346,918
<SENIOR-LONG-TERM-DEBT> 0
<OTHER-ITEMS-LIABILITIES> 147,782,350
<TOTAL-LIABILITIES> 180,129,268
<SENIOR-EQUITY> 0
<PAID-IN-CAPITAL-COMMON> 1,092,644,397
<SHARES-COMMON-STOCK> 53,470,447
<SHARES-COMMON-PRIOR> 52,501,218
<ACCUMULATED-NII-CURRENT> (58,299)
<OVERDISTRIBUTION-NII> 0
<ACCUMULATED-NET-GAINS> 104,616,673
<OVERDISTRIBUTION-GAINS> 0
<ACCUM-APPREC-OR-DEPREC> 267,368,262
<NET-ASSETS> 1,464,571,033
<DIVIDEND-INCOME> 18,878,917
<INTEREST-INCOME> 591,872
<OTHER-INCOME> 0
<EXPENSES-NET> 15,576,007
<NET-INVESTMENT-INCOME> 3,894,782
<REALIZED-GAINS-CURRENT> 106,851,708
<APPREC-INCREASE-CURRENT> (33,445,162)
<NET-CHANGE-FROM-OPS> 77,301,328
<EQUALIZATION> 0
<DISTRIBUTIONS-OF-INCOME> 3,743,838
<DISTRIBUTIONS-OF-GAINS> 177,581,351
<DISTRIBUTIONS-OTHER> 0
<NUMBER-OF-SHARES-SOLD> 2,182,584
<NUMBER-OF-SHARES-REDEEMED> 10,611,813
<SHARES-REINVESTED> 9,398,458
<NET-CHANGE-IN-ASSETS> (46,121,807)
<ACCUMULATED-NII-PRIOR> (58,299)
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<PER-SHARE-NAV-BEGIN> 21.360
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<PER-SHARE-NAV-END> 19.030
<EXPENSE-RATIO> 0.85
</TABLE>
