<PAGE>
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
Form 13F
FORM 13F COVER PAGE
Report for the Calendar Year or Quarter Ended: March 31, 2000
--------------
Check here if Amendment [ ]: Amendment Number: _______
This Amendment (Check only one): [ ] is a restatement.
[ ] adds new holdings entries.
Institutional Investment Manager Filing this Report:
Name: Howard Hughes Medical Institute
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Address: 4000 Jones Bridge Road
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Chevy Chase, MD 20815-6789
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Form 13F File Number: 28-1897
----
The institutional investment manager filing this report and the person by whom
it is signed hereby represent that the person signing the report is authorized
to submit it, that all information contained herein is true, correct and
complete, and that it is understood that all required items, statements,
schedules, lists, and tables, are considered integral parts of this form.
Person signing this Report on Behalf of Reporting Manager:
Name: Richard A. Pender
----------------------------
Title: Managing Director - Equities
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Phone: (301) 215-8697
----------------------------
Signature, Place, and Date of Signing:
Chevy Chase, Maryland
- ---------------------- ---------------------------- -------
[Signature] [City, State] [Date]
Report Type (Check only one):
[X] 13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager
are reported in this report.)
[ ] 13F NOTICE. (Check here if no holdings reported are in this report, and
all holdings are reported by other reporting manager(s).)
[ ] 13F COMBINATION REPORT. (Check here if a portion of the holdings for this
reporting manager are reported in this report and a portion are reported by
other reporting manager(s).)
<PAGE>
FORM 13F SUMMARY PAGE
Report Summary:
Number of Other Included Managers: None
-------------
Form 13F Information Table Entry Total: 119
---
Form 13F Information Table Value Total: 2,018,846
(thousands)
List of Other Included Managers:
None.
Provide a numbered list of the name(s) and Form 13F file number(s) of all
institutional investment managers with respect to which this report is filed,
other than the manager filing this report.
[If there are no entries in this list, state "NONE" and omit the column headings
and list entries.]
<PAGE>
FORM 13F INFORMATION TABLE
<TABLE>
<CAPTION>
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7
---------------------------------------------------------------------------------------------------
- ----------------------------- VALUE SHRS OR SH/ PUT/ INVSTMT OTHER
NAME OF ISSUER TITLE OF CLASS CUSIP (X$1000) PRN AMT PRN CALL DSCRETN MANAGERS
- ---------------------------------------------------------------------------------------------------------------------------------
<S> <C> <C> <C> <C> <C> <C> <C> <C>
3COM CORP COMMON 885535 10 4 48,116 865,000 SH N/A SOLE N/A
ALCOA INC COMMON 013817 10 1 3,513 50,000 SH N/A SOLE N/A
ALLOS THERAPEUTICS COMMON 019777 10 1 286 20,000 SH N/A SOLE N/A
ALLTEL CORP COMMON 020039 10 3 48,386 765,000 SH N/A SOLE N/A
AMERICA ONLINE INC COMMON 02364J 10 4 29,335 435,000 SH N/A SOLE N/A
AMERICAN EXPRESS COMPANY COMMON 025816 10 9 14,894 100,000 SH N/A SOLE N/A
AMERICAN GENERAL CORP COMMON 026351 10 6 13,470 240,000 SH N/A SOLE N/A
AMERICAN HOME PRODUCTS COMMON 026609 10 7 16,663 310,000 SH N/A SOLE N/A
AMERICAN INTL GROUP COMMON 026874 10 7 27,786 253,750 SH N/A SOLE N/A
AMGEN INC COMMON 031162 10 0 16,264 265,000 SH N/A SOLE N/A
AON CORP COMMON 037389 10 3 564 17,500 SH N/A SOLE N/A
APPLE COMPUTER COMMON 037833 10 0 39,386 290,000 SH N/A SOLE N/A
APPLIED MATERIALS INC COMMON 038222 10 5 15,080 160,000 SH N/A SOLE N/A
A T & T CORP COMMON 001957 10 9 22,525 400,000 SH N/A SOLE N/A
AUTOMATIC DATA PROCESSING COMMON 053015 10 3 7,238 150,000 SH N/A SOLE N/A
BANK OF AMERICA CORP COMMON 06605f 10 2 25,694 490,000 SH N/A SOLE N/A
BANK ONE CORP COMMON 06423A 10 3 1,018 29,500 SH N/A SOLE N/A
BAXTER INTERNATIONAL INC COMMON 071813 10 9 10,030 160,000 SH N/A SOLE N/A
BP AMOCO PLC SPONSORED ADR 055622 10 4 14,378 270,000 SH N/A SOLE N/A
BRISTOL-MYERS SQUIBB CO COMMON 110122 10 8 22,040 380,000 SH N/A SOLE N/A
CARDINAL HEALTH INC COMMON 14149Y 10 8 6,514 142,000 SH N/A SOLE N/A
CELL THERAPEUTICS INC COMMON 150934 10 7 2,344 100,000 SH N/A SOLE N/A
CHASE MANHATTAN CORP COMMON 16161A 10 8 17,438 200,000 SH N/A SOLE N/A
CHEVRON CORPORATION COMMON 166751 10 7 21,261 230,000 SH N/A SOLE N/A
CISCO SYSTEMS INC COMMON 17275R 10 2 66,489 860,000 SH N/A SOLE N/A
CITIGROUP INC COMMON 172967 10 1 43,005 718,250 SH N/A SOLE N/A
COMPAQ COMPUTER CORP COMMON 204493 10 0 6,750 250,000 SH N/A SOLE N/A
COMPUTER ASSOC INTL INC COMMON 204912 10 9 7,398 125,000 SH N/A SOLE N/A
CONSECO INC COMMON 208464 10 7 458 40,000 SH N/A SOLE N/A
COSTCO WHOLESALE CORP COMMON 22160K 10 5 8,936 170,000 SH N/A SOLE N/A
CURAGEN CORP COMMON 23126R 10 1 1,403 30,000 SH N/A SOLE N/A
CVS CORP COMMON 126650 10 0 15,964 425,000 SH N/A SOLE N/A
DANAHER CORPORATION COMMON 235851 10 2 13,051 255,900 SH N/A SOLE N/A
DELL COMPUTER CORP COMMON 247025 10 9 15,372 285,000 SH N/A SOLE N/A
DISNEY WALT CO COMMON 254687 10 6 15,675 380,000 SH N/A SOLE N/A
DOVER CORP COMMON 260003 10 8 6,564 137,100 SH N/A SOLE N/A
DU PONT (EI) DE NEMOURS COMMON 263534 10 9 18,639 352,100 SH N/A SOLE N/A
EMC CORPORATION COMMON 268648 10 2 20,160 160,000 SH N/A SOLE N/A
ENRON CORPORATION COMMON 293561 10 6 12,729 170,000 SH N/A SOLE N/A
EQUIFAX INC COMMON 294429 10 5 5,030 199,200 SH N/A SOLE N/A
EQUITY OFFICE PROPERTIES TRUST COMMON 294741 10 3 8,794 350,000 SH N/A SOLE N/A
ETHAN ALLEN INTERIORS COMMON 297602 10 4 2,000 80,000 SH N/A SOLE N/A
EXXON MOBIL CORP COMMON 30231G 10 2 43,918 563,500 SH N/A SOLE N/A
FANNIE MAE COMMON 313586 10 9 27,716 490,000 SH N/A SOLE N/A
FEDERATED DEPARTMENT STORES COMMON 31410H 10 1 6,169 146,000 SH N/A SOLE N/A
FORD MOTOR COMPANY COMMON 345370 10 0 10,106 220,000 SH N/A SOLE N/A
FOX ENTERTAINMENT GROUP INC CLASS A 35138T 10 7 22,753 760,000 SH N/A SOLE N/A
FRANKLIN RESOURCES INC COMMON 354613 10 1 6,688 200,000 SH N/A SOLE N/A
GANNETT CO INC COMMON 364730 10 1 28,502 405,000 SH N/A SOLE N/A
GENENTECH INC COMMON 368710 40 6 1,672 11,000 SH N/A SOLE N/A
GENERAL DYNAMICS CORP COMMON 369550 10 8 11,124 223,600 SH N/A SOLE N/A
GENERAL ELECTRIC COMPANY COMMON 369604 10 3 83,664 537,600 SH N/A SOLE N/A
GLOBALSTAR TELECOMMUNICATION COMMON G3930H 10 4 4,648 335,000 SH N/A SOLE N/A
GTE CORP COMMON 362320 10 3 26,270 370,000 SH N/A SOLE N/A
HEWLETT-PACKARD CO COMMON 428236 10 3 28,568 215,000 SH N/A SOLE N/A
HOME DEPOT INC COMMON 437076 10 2 19,350 300,000 SH N/A SOLE N/A
HUMAN GENOME SCIENCES INC COMMON 444903 10 8 1,661 20,000 SH N/A SOLE N/A
ILLINOIS TOOL WORKS INC COMMON 452308 10 9 646 11,700 SH N/A SOLE N/A
<CAPTION>
COLUMN 1 COLUMN 8
--------------------------
- ----------------------------- VOTING AUTHORITY
NAME OF ISSUER SOLE SHARED NONE
- --------------------------------------------------------
<S> <C> <C> <C>
3COM CORP X N/A N/A
ALCOA INC X N/A N/A
ALLOS THERAPEUTICS X N/A N/A
ALLTEL CORP X N/A N/A
AMERICA ONLINE INC X N/A N/A
AMERICAN EXPRESS COMPANY X N/A N/A
AMERICAN GENERAL CORP X N/A N/A
AMERICAN HOME PRODUCTS X N/A N/A
AMERICAN INTL GROUP X N/A N/A
AMGEN INC X N/A N/A
AON CORP X N/A N/A
APPLE COMPUTER X N/A N/A
APPLIED MATERIALS INC X N/A N/A
A T & T CORP X N/A N/A
AUTOMATIC DATA PROCESSING X N/A N/A
BANK OF AMERICA CORP X N/A N/A
BANK ONE CORP X N/A N/A
BAXTER INTERNATIONAL INC X N/A N/A
BP AMOCO PLC X N/A N/A
BRISTOL-MYERS SQUIBB CO X N/A N/A
CARDINAL HEALTH INC X N/A N/A
CELL THERAPEUTICS INC X N/A N/A
CHASE MANHATTAN CORP X N/A N/A
CHEVRON CORPORATION X N/A N/A
CISCO SYSTEMS INC X N/A N/A
CITIGROUP INC X N/A N/A
COMPAQ COMPUTER CORP X N/A N/A
COMPUTER ASSOC INTL INC X N/A N/A
CONSECO INC X N/A N/A
COSTCO WHOLESALE CORP X N/A N/A
CURAGEN CORP X N/A N/A
CVS CORP X N/A N/A
DANAHER CORPORATION X N/A N/A
DELL COMPUTER CORP X N/A N/A
DISNEY WALT CO X N/A N/A
DOVER CORP X N/A N/A
DU PONT (EI) DE NEMOURS X N/A N/A
EMC CORPORATION X N/A N/A
ENRON CORPORATION X N/A N/A
EQUIFAX INC X N/A N/A
EQUITY OFFICE PROPERTIES TRUST X N/A N/A
ETHAN ALLEN INTERIORS X N/A N/A
EXXON MOBIL CORP X N/A N/A
FANNIE MAE X N/A N/A
FEDERATED DEPARTMENT STORES X N/A N/A
FORD MOTOR COMPANY X N/A N/A
FOX ENTERTAINMENT GROUP INC X N/A N/A
FRANKLIN RESOURCES INC X N/A N/A
GANNETT CO INC X N/A N/A
GENENTECH INC X N/A N/A
GENERAL DYNAMICS CORP X N/A N/A
GENERAL ELECTRIC COMPANY X N/A N/A
GLOBALSTAR TELECOMMUNICATION X N/A N/A
GTE CORP X N/A N/A
HEWLETT-PACKARD CO X N/A N/A
HOME DEPOT INC X N/A N/A
HUMAN GENOME SCIENCES INC X N/A N/A
ILLINOIS TOOL WORKS INC X N/A N/A
</TABLE>
<PAGE>
FORM 13F INFORMATION TABLE
<TABLE>
<CAPTION>
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7
---------------------------------------------------------------------------------------------------
- ----------------------------- VALUE SHRS OR SH/ PUT/ INVSTMT OTHER
NAME OF ISSUER TITLE OF CLASS CUSIP (X$1000) PRN AMT PRN CALL DSCRETN MANAGERS
- ---------------------------------------------------------------------------------------------------------------------------------
<S> <C> <C> <C> <C> <C> <C> <C> <C>
IMMUNEX CORP COMMON 452528 10 2 5,709 90,000 SH N/A SOLE N/A
INTEL CORP COMMON 458140 10 0 85,100 645,000 SH N/A SOLE N/A
INTL BUSINESS MACHINES COMMON 459200 10 1 29,500 250,000 SH N/A SOLE N/A
JABIL CIRCUIT INC COMMON 466313 10 3 2,483 57,400 SH N/A SOLE N/A
JOHNSON & JOHNSON COMMON 478160 10 4 7,728 110,000 SH N/A SOLE N/A
KIMBERLY-CLARK CORP COMMON 494368 10 3 26,798 478,000 SH N/A SOLE N/A
KROGER COMPANY COMMON 501044 10 1 17,387 990,000 SH N/A SOLE N/A
LINCOLN NATIONAL CORP COMMON 534187 10 9 8,040 240,000 SH N/A SOLE N/A
LOWE'S COMPANIES COMMON 548661 10 7 10,624 182,000 SH N/A SOLE N/A
LUCENT TECHNOLOGIES INC COMMON 549463 10 7 33,994 555,000 SH N/A SOLE N/A
LUMINEX CORPORATION COMMON 55027E 10 2 324 15,000 SH N/A SOLE N/A
MARSH & MCLENNAN COMPANIES COMMON 571748 10 2 18,202 165,000 SH N/A SOLE N/A
MBNA CORPORATION COMMON 55262L 10 0 8,543 335,000 SH N/A SOLE N/A
MCGRAW-HILL COMPANIES INC COMMON 580645 10 9 17,745 390,000 SH N/A SOLE N/A
MCI WORLDCOM INC COMMON 55268B 10 6 16,992 375,000 SH N/A SOLE N/A
MEDIMMUNE INC COMMON 584699 10 2 1,741 10,000 SH N/A SOLE N/A
MEDIAONE GROUP INC COMMON 58440J 10 4 2,592 32,000 SH N/A SOLE N/A
MERCK & COMPANY INC COMMON 589331 10 7 25,471 410,000 SH N/A SOLE N/A
MICROSOFT CORP COMMON 594918 10 4 70,125 660,000 SH N/A SOLE N/A
MILLENNIUM PHARMACEUTICALS COMMON 599902 10 3 1,948 15,000 SH N/A SOLE N/A
MORGAN STANLEY, DEAN WITTER DISCOVER COMMON 617446 44 8 14,089 170,000 SH N/A SOLE N/A
MOTOROLA INC COMMON 620076 10 9 29,200 200,000 SH N/A SOLE N/A
MYRIAD GENETICS INC COMMON 62855J 10 4 753 12,500 SH N/A SOLE N/A
NEWELL RUBBERMAID INC COMMON 651229 10 6 10,744 433,000 SH N/A SOLE N/A
NORTEL NETWORKS CORP COMMON 656569 10 0 46,666 370,000 SH N/A SOLE N/A
ORACLE CORPORATION COMMON 68389X 10 5 41,763 535,000 SH N/A SOLE N/A
PALM INC COMMON 69332S 10 2 494 11,000 SH N/A SOLE N/A
PE CORP-PE BIOSYSTEMS GROUP CLASS B 69332S 10 2 1,930 20,000 SH N/A SOLE N/A
PEPSICO INC COMMON 713448 10 8 24,761 710,000 SH N/A SOLE N/A
PFIZER INC COMMON 717081 10 3 18,281 500,000 SH N/A SOLE N/A
PHARMACIA & UPJOHN INC COMMON 716941 10 9 20,825 350,000 SH N/A SOLE N/A
PROCTER & GAMBLE COMPANY COMMON 742718 10 9 13,560 240,000 SH N/A SOLE N/A
PROTEIN DESIGN LABS INC COMMON 74369L 10 3 795 10,000 SH N/A SOLE N/A
QUALCOMM INC COMMON 747525 10 3 26,876 180,000 SH N/A SOLE N/A
RALSTON PURINA GROUP COMMON 751277 30 2 15,758 573,000 SH N/A SOLE N/A
SANMINA CORP COMMON 800907 10 7 8,337 123,400 SH N/A SOLE N/A
SBC COMMUNICATIONS INC COMMON 78387G 10 3 23,169 550,000 SH N/A SOLE N/A
SCHLUMBERGER LTD COMMON 806857 10 8 30,042 392,700 SH N/A SOLE N/A
SCI SYSTEMS INC COMMON 783890 10 6 7,143 132,900 SH N/A SOLE N/A
SOLECTRON CORP COMMON 834182 10 7 14,517 361,800 SH N/A SOLE N/A
SPRINT CORP (FON GROUP) COMMON 949746 10 1 8,855 140,000 SH N/A SOLE N/A
TARGET CORP COMMON 87612E 10 6 14,801 198,000 SH N/A SOLE N/A
TENET HEALTHCARE CORP COMMON 88033G 10 0 10,230 440,000 SH N/A SOLE N/A
TEXACO INC COMMON 881694 10 3 9,675 180,000 SH N/A SOLE N/A
TEXAS INSTRUMENTS INC COMMON 882508 10 4 26,400 165,000 SH N/A SOLE N/A
TEXAS UTILITIES CO (HLDG) COMMON 882848 10 4 7,719 260,000 SH N/A SOLE N/A
TIME WARNER INC COMMON 887315 10 9 31,000 310,000 SH N/A SOLE N/A
TRANSKARYOTIC THERAPIES INC COMMON 893735 10 0 1,669 30,000 SH N/A SOLE N/A
TRANSOCEAN OFFSHORE INC COMMON KYG9007610 12,997 253,299 SH N/A SOLE N/A
TYCO INTERNATIONAL LTD COMMON 902124 10 6 10,526 210,000 SH N/A SOLE N/A
UNITED PARCEL SERVICE CLASS B 911312 10 6 10,078 160,000 SH N/A SOLE N/A
U S BANCORP COMMON 902973 10 6 8,531 390,000 SH N/A SOLE N/A
VERTEX PHARMACEUTICALS INC COMMON 92532F 10 0 1,287 27,500 SH N/A SOLE N/A
WAL-MART STORES INC COMMON 931142 10 3 24,295 430,000 SH N/A SOLE N/A
WARNER-LAMBERT COMPANY COMMON 934488 10 7 23,445 240,000 SH N/A SOLE N/A
WASHINGTON MUTUAL INC COMMON 939322 10 3 398 15,000 SH N/A SOLE N/A
WELLPOINT HEALTH NETWORKS COMMON 94973H 10 8 11,180 160,000 SH N/A SOLE N/A
WELLS FARGO COMMON 949746 10 1 204 5,000 SH N/A SOLE N/A
WEYERHAEUSER CO COMMON 962166 10 4 14,809 259,800 SH N/A SOLE N/A
WILLIAMS COMMUNICATIONS GROUP COMMON 969455 10 4 22,047 425,000 SH N/A SOLE N/A
WILLIAMS COS INC COMMON 969457 10 0 11,863 270,000 SH N/A SOLE N/A
<CAPTION>
<S> <C> <C> <C>
IMMUNEX CORP X N/A N/A
INTEL CORP X N/A N/A
INTL BUSINESS MACHINES X N/A N/A
JABIL CIRCUIT INC X N/A N/A
JOHNSON & JOHNSON X N/A N/A
KIMBERLY-CLARK CORP X N/A N/A
KROGER COMPANY X N/A N/A
LINCOLN NATIONAL CORP X N/A N/A
LOWE'S COMPANIES X N/A N/A
LUCENT TECHNOLOGIES INC X N/A N/A
LUMINEX CORPORATION X N/A N/A
MARSH & MCLENNAN COMPANIES X N/A N/A
MBNA CORPORATION X N/A N/A
MCGRAW-HILL COMPANIES INC X N/A N/A
MCI WORLDCOM INC X N/A N/A
MEDIMMUNE INC X N/A N/A
MEDIAONE GROUP INC X N/A N/A
MERCK & COMPANY INC X N/A N/A
MICROSOFT CORP X N/A N/A
MILLENNIUM PHARMACEUTICALS X N/A N/A
MORGAN STANLEY, DEAN WITTER DI X N/A N/A
MOTOROLA INC X N/A N/A
MYRIAD GENETICS INC X N/A N/A
NEWELL RUBBERMAID INC X N/A N/A
NORTEL NETWORKS CORP X N/A N/A
ORACLE CORPORATION X N/A N/A
PALM INC X N/A N/A
PE CORP-PE BIOSYSTEMS GROUP X N/A N/A
PEPSICO INC X N/A N/A
PFIZER INC X N/A N/A
PHARMACIA & UPJOHN INC X N/A N/A
PROCTER & GAMBLE COMPANY X N/A N/A
PROTEIN DESIGN LABS INC X N/A N/A
QUALCOMM INC X N/A N/A
RALSTON PURINA GROUP X N/A N/A
SANMINA CORP X N/A N/A
SBC COMMUNICATIONS INC X N/A N/A
SCHLUMBERGER LTD X N/A N/A
SCI SYSTEMS INC X N/A N/A
SOLECTRON CORP X N/A N/A
SPRINT CORP (FON GROUP) X N/A N/A
TARGET CORP X N/A N/A
TENET HEALTHCARE CORP X N/A N/A
TEXACO INC X N/A N/A
TEXAS INSTRUMENTS INC X N/A N/A
TEXAS UTILITIES CO (HLDG) X N/A N/A
TIME WARNER INC X N/A N/A
TRANSKARYOTIC THERAPIES INC X N/A N/A
TRANSOCEAN OFFSHORE INC X N/A N/A
TYCO INTERNATIONAL LTD X N/A N/A
UNITED PARCEL SERVICE X N/A N/A
U S BANCORP X N/A N/A
VERTEX PHARMACEUTICALS INC X N/A N/A
WAL-MART STORES INC X N/A N/A
WARNER-LAMBERT COMPANY X N/A N/A
WASHINGTON MUTUAL INC X N/A N/A
WELLPOINT HEALTH NETWORKS X N/A N/A
WELLS FARGO X N/A N/A
WEYERHAEUSER CO X N/A N/A
WILLIAMS COMMUNICATIONS GROUP X N/A N/A
WILLIAMS COS INC X N/A N/A
</TABLE>
