NEOPROBE CORP
S-8, 1997-02-04
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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<PAGE>   1
  As filed with the Securities and Exchange Commission on February 4, 1997

                                                Registration No. 333-___________

================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                   ----------

                                    FORM S-8

                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933


                              Neoprobe Corporation
- --------------------------------------------------------------------------------
             (Exact Name of Registrant as Specified in Its Charter)

                                    Delaware
- --------------------------------------------------------------------------------
         (State or Other Jurisdiction of Incorporation or Organization)

                                   31-1080091
- --------------------------------------------------------------------------------
                      (I.R.S. Employer Identification No.)

            425 Metro Place North, Suite 400, Dublin, Ohio 43017-1367
- --------------------------------------------------------------------------------
               (Address of Principal Executive Offices) (Zip Code)

                       Restricted Stock Purchase Agreement
- --------------------------------------------------------------------------------
                            (Full Title of the Plan)

      Robert S. Schwartz, c/o Benesch, Friedlander, Coplan & Aronoff P.L.L.
           88 East Broad Street, Suite 900, Columbus, Ohio 43215-3506
- --------------------------------------------------------------------------------
                     (Name and Address of Agent For Service)


                                  614-223-9300
- --------------------------------------------------------------------------------
          Telephone Number, Including Area Code, of Agent For Service.


                         CALCULATION OF REGISTRATION FEE



<TABLE>
<CAPTION>
============================================= ================== ================= ================= ===================
                                                                     PROPOSED          PROPOSED
                                                                      MAXIMUM           MAXIMUM
             Title of securities                 AMOUNT TO BE     OFFERING PRICE       AGGREGATE          AMOUNT OF
              to be registered                    REGISTERED       PER SHARE(2)    OFFERING PRICE(2) REGISTRATION FEE(3)
- --------------------------------------------- ------------------ ----------------- ----------------- -------------------

<S>                                                 <C>                <C>              <C>                <C>    
        COMMON STOCK, $.001 PAR VALUE(1)            10,000             $.001            $10.00             $100.00

============================================= ================== ================= ================= ===================
<FN>
(1) Each share of Common Stock carries one right to purchase a unit which
    currently consists of one-hundredth of a share of Series A Junior
    Participating Preferred Stock, par value $.001 per share, pursuant to a
    Rights Agreement dated July 18, 1995. 
(2) The proposed maximum offering price per share of $.001 is based upon the 
    aggregate offering price of the maximum number of securities issuable under 
    the above referenced Restricted Stock Purchase Agreement pursuant to 
    paragraph (h) of Rule 457. 
(3) The registration fee is the minimum registration fee pursuant to Section 
    6(b) of the Securities Act of 1933.
</TABLE>


<PAGE>   2



                                     PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT


ITEM 3.  INCORPORATION OF DOCUMENTS BY REFERENCE.

        The documents listed in (a) through (d) below are incorporated by
reference in this registration statement; and all documents subsequently filed
by Neoprobe Corporation, a Delaware corporation (the "Registrant") pursuant to
Sections 13(a), 13(c), 14 and 15(d) of the Securities and Exchange Act of 1934
(the "Exchange Act"), prior to the filing of a post-effective amendment which
indicates that all securities offered hereunder have been sold or which
deregisters all securities then remaining unsold, shall be deemed to be
incorporated by reference in this registration statement and to be part hereof
from the date of filing of such documents.

        (a)  The Registrant's latest annual report on Form 10-KSB (Commission
             File No. 0-26520), filed pursuant to Section 13(a) of the Exchange
             Act.

        (b)  All other reports filed pursuant to Section 13(a) or 15(d) of the
             Exchange Act since the end of the fiscal year covered by the
             Registrant's annual report referred to in (a) above.

        (c)  The description of the Registrant's Common Stock contained in the
             Registrant's Registration Statement on Form 8-A, as amended by
             Amendment No. 6 (Commission File No. 0-26520), including any
             amendment or report filed for the purpose of updating such
             description.

        (d)  The description of Rights to Purchase Series A Junior Participating
             Preferred Stock contained in the Registrant's Registration
             Statement on Form 8-A (Commission File No. 0-26520).

ITEM 4.  DESCRIPTION OF SECURITIES.

     Not Applicable.

ITEM 5.  INTERESTS OF NAMED EXPERTS AND COUNSEL.

     The validity of the Common Stock of the Registrant issuable under the Plan
will be passed upon for the Registrant by Benesch, Friedlander, Coplan & Aronoff
P.L.L., Columbus, Ohio.

ITEM 6.  INDEMNIFICATION OF OFFICERS AND DIRECTORS.

     Section 145 of the General Corporation Law of the State of Delaware
("Section 145") provides that directors and officers of Delaware corporations
are entitled, under certain circumstances, to be indemnified against expenses
(including attorneys' fees) and other liabilities actually and reasonably
incurred by them as a result of any suit brought against them in their capacity
as a director or officer, if they acted in good faith and in a manner they
reasonably believed to be in or not opposed to the best interests of the
corporation, and, with respect to any criminal action or proceeding, if they had
no reasonable cause to believe their conduct was unlawful. Section 145 also
provides that directors and officers may also be indemnified against expenses
(including attorneys' fees) incurred by them in connection with a derivative
suit if they acted in good faith and in a manner they reasonably believed to be
in or not opposed to the best interests of the corporation, except that no
indemnification may be made without court approval if such person was adjudged
liable to the corporation.

     Article V of the Company's By-laws has provisions requiring the Company to
indemnify its officers, directors, employees and agents which are in
substantially the same language as Section 145.


                                       -2-




<PAGE>   3



     Article Nine, section (b), of the Company's Certificate of Incorporation
further provides that no director will be personally liable to the Company or
its stockholders for monetary damages or for any breach of fiduciary duty except
for breach of the director's duty of loyalty to the Company or its stockholders,
for acts or omissions not in good faith or involving intentional misconduct or a
knowing violation of law, pursuant to section 174 of the Delaware General
Corporation Law (which imposes liability in connection with the payment of
certain unlawful dividends, stock purchases or redemptions), or any amendment or
successor provision thereto, or for any transaction from which the director
derived an improper personal benefit.

ITEM 7.  EXEMPTION FROM REGISTRATION CLAIMED.

     Not Applicable.

ITEM 8.  EXHIBITS.

     The following Exhibits are filed as part of this Registration Statement:

(4)  Instruments Defining the Rights of Security Holders.

              4.1.    See Articles FOUR, FIVE, SIX, SEVEN and EIGHT of the
                      Restated Certificate of Incorporation of the Registrant
                      (incorporated by reference to Exhibit 99.1 of Registrant's
                      Current Report on Form 8-K, dated June 20, 1996;
                      Commission File No. 0-26520).

              4.2.    See Articles II and VI and Section 2 of Article III and
                      Section 4 of Article VII of the Amended and Restated
                      By-Laws (incorporated by reference to Exhibit 99.4 of
                      Registrant's Current Report on Form 8-K, dated June 20,
                      1996; Commission File No. 0-26520).

              4.3.    Rights Agreement dated as of July 18, 1995 between the
                      Registrant and Continental Stock Transfer & Trust Company
                      (incorporated by reference to Exhibit 1 to Form 8-A dated
                      July 27, 1995; Commission File No. 0-26520).

(5)  Opinion re Legality.

              5.1.    Opinion of Benesch, Friedlander, Coplan & Aronoff P.L.L.
                      as to the validity of the Common Stock being registered
                      hereunder.

(23)  Consents of Experts and Counsel.

              23.1.   Consent of Coopers & Lybrand L.L.P.

              23.2.   Consent of Benesch, Friedlander, Coplan & Aronoff P.L.L.
                      is set forth as part of Exhibit 5.1 above.

(24)  Powers of Attorney.

              24.1.   Powers of Attorney.

              24.2.   Certified copy of resolution of Registrant's Board of
                      Directors authorizing officers and directors signing on
                      behalf of the Registrant to sign pursuant to a power of
                      attorney.

ITEM 9.  UNDERTAKINGS.

     (a) Not applicable.

                                       -3-




<PAGE>   4



     (b) The undersigned Registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act of 1933, each filing of the
Registrant's annual report pursuant to Section 13(a) or 15(d) of the Securities
Exchange Act of 1934 that is incorporated by reference in the registration
statement shall be deemed to be a new registration statement relating to the
securities offered therein, and the offering of such securities at that time
shall be deemed to be the initial bona fide offering thereof.

     (h) Insofar as indemnification for liabilities arising under the Securities
Act of 1933 may be permitted to directors, officers and controlling persons of
the Registrant pursuant to the foregoing provisions, or otherwise, the
Registrant has been advised that in the opinion of the Securities and Exchange
Commission such indemnification is against public policy as expressed in the Act
and is, therefore, unenforceable. In the event that a claim for indemnification
against such liabilities (other than the payment by the Registrant of expenses
incurred or paid by a director, officer or controlling person of the Registrant
in the successful defense of any action, suit or proceeding) is asserted by such
director, officer or controlling person in connection with the securities being
registered, the Registrant will, unless in the opinion of its counsel the matter
has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public
policy as expressed in the Act and will be governed by the final adjudication of
such issue.



                                       -4-




<PAGE>   5




                                   SIGNATURES

      Pursuant to the requirements of the Securities Act of 1933, the Registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this registration
statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Columbus, State of Ohio, this 23rd day of January,
1997.

                                                         NEOPROBE CORPORATION
                                                             (Registrant)


                                                        By: /s/DAVID C. BUPP
                                                            --------------------
                                                            David C. Bupp
                                                            President

      Pursuant to the requirements of the Securities Act of 1933, this
registration statement has been signed by the following persons in the
capacities indicated on January 23, 1997.

<TABLE>
<CAPTION>
        Signature                                                       Title
        ---------                                                       -----

<S>                                                      <C>
JOHN L. RIDIHALGH*                                       Director, Chairman of the Board, and Chief Executive
- -------------------------                                Officer (principal executive officer)
John L. Ridihalgh                                        

/s/DAVID C. BUPP                                         Director, President, and Chief Operating Officer
- -------------------------
David C. Bupp

JOHN SCHROEPFER*                                         Vice President, Finance and Administration
- -------------------------                                (principal financial and accounting officer)
John Schroepfer                                          

JERRY K. MUELLER, JR.*                                   Director
- -------------------------
Jerry K. Mueller, Jr.

C. MICHAEL HAZARD*                                       Director
- -------------------------
C. Michael Hazard

JULIUS R. KREVANS*                                       Director
- -------------------------
Julius R. Krevans

MICHAEL P. MOORE*                                        Director
- -------------------------
Michael P. Moore

J. FRANK WHITLEY, JR.*                                   Director
- -------------------------
J. Frank Whitley, Jr.

JAMES F. ZID*                                            Director
- -------------------------
James F. Zid

ZWI VROMEN*                                              Director
- -------------------------
Zwi Vromen

<FN>
*David C. Bupp, by signing his name hereto, does sign this document on behalf of
the person indicated above pursuant to a Power of Attorney duly executed by such
person.
</TABLE>

By:/s/DAVID C. BUPP
   --------------------------------------
   David C. Bupp, Attorney-in-Fact

                                       -5-




<PAGE>   6




                                  EXHIBIT INDEX



<TABLE>
<CAPTION>
                                                                                                      PAGE NUMBER IN
                                                                                                       SEQUENTIALLY
                                                                                                         NUMBERED
                                                                                                           COPY

<C>                                                                                                <C>
4.1.       See Articles FOUR, FIVE, SIX, SEVEN and EIGHT of the Restated Certificate of            
           Incorporation of the Registrant (incorporated by reference to Exhibit 99.1 of
           Registrant's Current Report on Form 8-K, dated June 20, 1996; Commission File                   
           No. 0-26520).                                                                                   
                                                                                                          *

4.2.       See Articles II and VI and Section 2 of Article III and Section 4 of Article VII of the 
           Amended and Restated By-Laws (incorporated by reference to Exhibit 99.4 of
           Registrant's Current Report on Form 8-K, dated June 20, 1996; Commission File                   
           No. 0-26520).                                                                                   
                                                                                                          *

4.3.       Rights Agreement dated as of July 18, 1995 between the Registrant and Continental      
           Stock Transfer & Trust Company (incorporated by reference to Exhibit 1 to Form
           8-A dated July 27, 1995; Commission File No. 0-26520).                                 
                                                                                                          *

5.1.       Opinion of Benesch, Friedlander, Coplan & Aronoff P.L.L. as to the validity of the     
           Common Stock being registered hereunder.
                                                                                                          7

23.1.      Consent of Coopers & Lybrand L.L.P.                                                            9   

23.2.      Consent of Benesch, Friedlander, Coplan & Aronoff P.L.L. is set forth as part of        
           Exhibit 5.1 above.

24.1.      Powers of Attorney.                                                                            10

24.2.      Certified copy of resolution of Registrant's Board of Directors authorizing officers   
           and directors signing on behalf of the Registrant to sign pursuant to a power of
           attorney.                                                                                       
                                                                                                          19
<FN>
*    Incorporated by reference.
</TABLE>


                                       -6-





<PAGE>   1


ROBERT S. SCHWARTZ                                 WRITER'S DIRECT DIAL NUMBER
                                                                (614) 223-9304

                                                                   EXHIBIT 5.1
                                                                         &
                                                                  EXHIBIT 23.2

                                January 23, 1997


Neoprobe Corporation
425 Metro Place North, Suite 400
Dublin, Ohio 43017

     Re: REGISTRATION OF NEOPROBE CORPORATION
         RESTRICTED STOCK PURCHASE AGREEMENT WITH JOSEPH R. BIANCHINE,
         M.D., PH.D. DATED NOVEMBER 25, 1996, AMENDED JANUARY 1, 1997

Gentlemen:

     You have requested our opinion in connection with the issuance of Common
Stock ("Common Stock") of Neoprobe Corporation, a Delaware corporation (the
"Company"), under the Neoprobe Corporation Restricted Stock Purchase Agreement
with Joseph R. Bianchine, M.D., Ph.D. dated November 25, 1996, Amended January
1, 1997 (the "Agreement"), which is being registered with the Securities and
Exchange Commission pursuant to a Registration Statement on Form S-8 (the
"Registration Statement").

     We have acted as counsel to the Company in connection with the Agreement.
While we represent the Company on a regular basis, our advice and representation
have been limited to the specific matters referred to us from time to time by
the Company; accordingly, we may be unaware of certain matters of a legal nature
concerning the Company.

     For the purpose of giving this opinion, we have examined and relied upon
the following documents and instruments which, to our knowledge and in our
judgment, are all of the documents and instruments that are necessary for us to
examine for such purpose.

     1.  A copy of the Company's Amended and Restated Articles of Incorporation;

     2.  A copy of the Company's Amended and Restated By-Laws;

     3.  The Agreement;

     4.  The minute books of the Company;

     5.  An officer's certificate executed by an officer of the Company 
         certifying certain factual information; and

                                       -7-




<PAGE>   2






     6.  A secretary's certificate executed by the secretary of the Company 
         certifying certain factual information.

     In giving our opinion, we have assumed without investigation the
authenticity of any document or instrument submitted to us as an original, the
conformity to the authentic original of any document or instrument submitted to
us as a certified, conformed or photostatic copy, the genuineness of all
signatures on such originals or copies and the legal capacity of each signatory.

     Based upon the foregoing, we are of the opinion that when the Common Stock
is issued under the Agreement and the Company has received the purchase price
under the Agreement (which purchase price may not be less than par value of the
Common Stock) in the form of cash, services rendered, personal property, real
property, leases of real property, or a combination thereof, the Common Stock
sold under the Agreement will be validly issued, fully paid and nonassessable.

     Our opinion is subject to the following qualifications and limitations:

     i. The opinions expressed herein are subject to the effect of applicable
bankruptcy, insolvency, reorganization or similar laws affecting the enforcement
of creditors' rights in general and are subject to general principles of equity,
whether considered in actions at law or suits in equity.

     ii. Members of our firm are qualified to practice law in the State of Ohio
and nothing contained herein shall be deemed to be an opinion as to any law,
other than the laws of the State of Ohio and the federal law of the United
States.

     iii.The opinions set forth herein are expressed as of the date hereof and
we disclaim any undertaking to advise you of any changes which may subsequently
be brought to our attention in the facts and the law upon which such opinions
are based.

     This opinion is furnished by us solely for your benefit and is intended to
be used as an exhibit to the Registration Statement. Except for such use,
neither this opinion nor copies hereof may be relied upon by, delivered to, or
quoted in whole or in part to, any other person without our prior written
consent.

     We consent to the reference to our firm name under the caption "Interests
of Named Experts and Counsel" in the Registration Statement and to the use of
our opinion as an exhibit to the Registration Statement. In giving these
consents, we do not admit that we come within the category of persons whose
consent is required under Section 7 of the Securities Act of 1933 or the rules
and regulations of the Securities and Exchange Commission promulgated
thereunder.

                                  Very truly yours,



                                  BENESCH, FRIEDLANDER, COPLAN & ARONOFF P.L.L.





                                       -8-




<PAGE>   1


                                                                    Exhibit 23.1






                       CONSENT OF INDEPENDENT ACCOUNTANTS


We consent to the incorporation by reference in this Registration Statement on
Form S-8 of our report dated February 16, 1996, on our audits of the
consolidated financial statements of Neoprobe Corporation and Subsidiaries,
which report is included in the Annual Report on Form 10-K.



                                        /s/  COOPERS & LYBRAND L.L.P.
                                        -----------------------------








Columbus, Ohio
January 31, 1997
- ----------------


                                       -9-



<PAGE>   1



                                                                    EXHIBIT 24.1

                                POWER OF ATTORNEY
                            OFFICERS AND DIRECTORS OF
                              NEOPROBE CORPORATION

The undersigned who is a director or officer of Neoprobe Corporation, a
     Delaware corporation (the "company");

Does hereby constitute and appoint John L. Ridihalgh and David C. Bupp to be his
     agents and attorneys-in-fact;

Each with the power to act fully hereunder without the other and with full power
     of substitution to act in the name and on behalf of the undersigned;

To sign and file with the Securities and Exchange Commission one or more
     Registration Statements on Form S-8 under the Securities Act of 1933, and
     any amendments or supplements (including post-effective amendments) to such
     Registration Statements; and

To execute and deliver any instruments, certificates or other documents which
     they shall deem necessary or proper in connection with the filing of such
     Registration Statements, and generally to act for and in the name of the
     undersigned with respect to such filings as fully as could the undersigned
     if then personally present and acting.

Each agent named above is hereby empowered to determine in his discretion the
     times when, the purposes for, and the names in which, any power conferred
     upon him herein shall be exercised and the terms and conditions of any
     instrument, certificate or document which may be executed by him pursuant
     to this instrument.

This Power of Attorney shall not be affected by the disability of the
     undersigned or the lapse of time.

The validity, terms and enforcement of this Power of Attorney shall be governed
     by those laws of the State of Ohio that apply to instruments negotiated,
     executed, delivered and performed solely within the State of Ohio.

This Power of Attorney may be executed in any number of counterparts, each of
     which shall have the same effect as if it were the original instrument and
     all of which shall constitute one and the same instrument.

IN WITNESS WHEREOF, I have executed this Power of Attorney this 23rd day of
     January, 1997.



                                                   /s/ John L. Ridihalgh
                                                   -----------------------------
                                                        John L. Ridihalgh



                                      -10-




<PAGE>   2




                                                                    EXHIBIT 24.1

                                POWER OF ATTORNEY
                            OFFICERS AND DIRECTORS OF
                              NEOPROBE CORPORATION

The undersigned who is a director or officer of Neoprobe Corporation, a
     Delaware corporation (the "company");

Does hereby constitute and appoint John L. Ridihalgh and David C. Bupp to be his
     agents and attorneys-in-fact;

Each with the power to act fully hereunder without the other and with full power
     of substitution to act in the name and on behalf of the undersigned;

To sign and file with the Securities and Exchange Commission one or more
     Registration Statements on Form S-8 under the Securities Act of 1933, and
     any amendments or supplements (including post-effective amendments) to such
     Registration Statements; and

To execute and deliver any instruments, certificates or other documents which
     they shall deem necessary or proper in connection with the filing of such
     Registration Statements, and generally to act for and in the name of the
     undersigned with respect to such filings as fully as could the undersigned
     if then personally present and acting.

Each agent named above is hereby empowered to determine in his discretion the
     times when, the purposes for, and the names in which, any power conferred
     upon him herein shall be exercised and the terms and conditions of any
     instrument, certificate or document which may be executed by him pursuant
     to this instrument.

This Power of Attorney shall not be affected by the disability of the
     undersigned or the lapse of time.

The validity, terms and enforcement of this Power of Attorney shall be governed
     by those laws of the State of Ohio that apply to instruments negotiated,
     executed, delivered and performed solely within the State of Ohio.

This Power of Attorney may be executed in any number of counterparts, each of
     which shall have the same effect as if it were the original instrument and
     all of which shall constitute one and the same instrument.

IN WITNESS WHEREOF, I have executed this Power of Attorney this 23rd day of
     January, 1997.


                                                     /s/ John Schroepfer
                                                     ---------------------------
                                                          John Schroepfer


                                      -11-




<PAGE>   3




                                                                    EXHIBIT 24.1

                                POWER OF ATTORNEY
                            OFFICERS AND DIRECTORS OF
                              NEOPROBE CORPORATION

The undersigned who is a director or officer of Neoprobe Corporation, a
     Delaware corporation (the "company");

Does hereby constitute and appoint John L. Ridihalgh and David C. Bupp to be his
     agents and attorneys-in-fact;

Each with the power to act fully hereunder without the other and with full power
     of substitution to act in the name and on behalf of the undersigned;

To sign and file with the Securities and Exchange Commission one or more
     Registration Statements on Form S-8 under the Securities Act of 1933, and
     any amendments or supplements (including post-effective amendments) to such
     Registration Statements; and

To execute and deliver any instruments, certificates or other documents which
     they shall deem necessary or proper in connection with the filing of such
     Registration Statements, and generally to act for and in the name of the
     undersigned with respect to such filings as fully as could the undersigned
     if then personally present and acting.

Each agent named above is hereby empowered to determine in his discretion the
     times when, the purposes for, and the names in which, any power conferred
     upon him herein shall be exercised and the terms and conditions of any
     instrument, certificate or document which may be executed by him pursuant
     to this instrument.

This Power of Attorney shall not be affected by the disability of the
     undersigned or the lapse of time.

The validity, terms and enforcement of this Power of Attorney shall be governed
     by those laws of the State of Ohio that apply to instruments negotiated,
     executed, delivered and performed solely within the State of Ohio.

This Power of Attorney may be executed in any number of counterparts, each of
     which shall have the same effect as if it were the original instrument and
     all of which shall constitute one and the same instrument.

IN WITNESS WHEREOF, I have executed this Power of Attorney this 23rd day of
     January, 1997.


                                                     /s/  C. Michael Hazard
                                                     ---------------------------
                                                           C. Michael Hazard


                                      -12-




<PAGE>   4




                                                                    EXHIBIT 24.1

                                POWER OF ATTORNEY
                            OFFICERS AND DIRECTORS OF
                              NEOPROBE CORPORATION

The undersigned who is a director or officer of Neoprobe Corporation, a
     Delaware corporation (the "company");

Does hereby constitute and appoint John L. Ridihalgh and David C. Bupp to be his
     agents and attorneys-in-fact;

Each with the power to act fully hereunder without the other and with full power
     of substitution to act in the name and on behalf of the undersigned;

To sign and file with the Securities and Exchange Commission one or more
     Registration Statements on Form S-8 under the Securities Act of 1933, and
     any amendments or supplements (including post-effective amendments) to such
     Registration Statements; and

To execute and deliver any instruments, certificates or other documents which
     they shall deem necessary or proper in connection with the filing of such
     Registration Statements, and generally to act for and in the name of the
     undersigned with respect to such filings as fully as could the undersigned
     if then personally present and acting.

Each agent named above is hereby empowered to determine in his discretion the
     times when, the purposes for, and the names in which, any power conferred
     upon him herein shall be exercised and the terms and conditions of any
     instrument, certificate or document which may be executed by him pursuant
     to this instrument.

This Power of Attorney shall not be affected by the disability of the
     undersigned or the lapse of time.

The validity, terms and enforcement of this Power of Attorney shall be governed
     by those laws of the State of Ohio that apply to instruments negotiated,
     executed, delivered and performed solely within the State of Ohio.

This Power of Attorney may be executed in any number of counterparts, each of
     which shall have the same effect as if it were the original instrument and
     all of which shall constitute one and the same instrument.

IN WITNESS WHEREOF, I have executed this Power of Attorney this 23rd day of
     January, 1997.


                                                     /s/ Jerry K. Mueller, Jr.
                                                     ---------------------------
                                                          Jerry K. Mueller, Jr.


                                      -13-




<PAGE>   5




                                                                    EXHIBIT 24.1

                                POWER OF ATTORNEY
                            OFFICERS AND DIRECTORS OF
                              NEOPROBE CORPORATION

The undersigned who is a director or officer of Neoprobe Corporation, a
     Delaware corporation (the "company");

Does hereby constitute and appoint John L. Ridihalgh and David C. Bupp to be his
     agents and attorneys-in-fact;

Each with the power to act fully hereunder without the other and with full power
     of substitution to act in the name and on behalf of the undersigned;

To sign and file with the Securities and Exchange Commission one or more
     Registration Statements on Form S-8 under the Securities Act of 1933, and
     any amendments or supplements (including post-effective amendments) to such
     Registration Statements; and

To execute and deliver any instruments, certificates or other documents which
     they shall deem necessary or proper in connection with the filing of such
     Registration Statements, and generally to act for and in the name of the
     undersigned with respect to such filings as fully as could the undersigned
     if then personally present and acting.

Each agent named above is hereby empowered to determine in his discretion the
     times when, the purposes for, and the names in which, any power conferred
     upon him herein shall be exercised and the terms and conditions of any
     instrument, certificate or document which may be executed by him pursuant
     to this instrument.

This Power of Attorney shall not be affected by the disability of the
     undersigned or the lapse of time.

The validity, terms and enforcement of this Power of Attorney shall be governed
     by those laws of the State of Ohio that apply to instruments negotiated,
     executed, delivered and performed solely within the State of Ohio.

This Power of Attorney may be executed in any number of counterparts, each of
     which shall have the same effect as if it were the original instrument and
     all of which shall constitute one and the same instrument.

IN WITNESS WHEREOF, I have executed this Power of Attorney this 23rd day of
     January, 1997.


                                                     /s/ Julius R. Krevans
                                                     ---------------------------
                                                          Julius R. Krevans


                                      -14-




<PAGE>   6




                                                                    EXHIBIT 24.1

                                POWER OF ATTORNEY
                            OFFICERS AND DIRECTORS OF
                              NEOPROBE CORPORATION

The undersigned who is a director or officer of Neoprobe Corporation, a
     Delaware corporation (the "company");

Does hereby constitute and appoint John L. Ridihalgh and David C. Bupp to be his
     agents and attorneys-in-fact;

Each with the power to act fully hereunder without the other and with full power
     of substitution to act in the name and on behalf of the undersigned;

To sign and file with the Securities and Exchange Commission one or more
     Registration Statements on Form S-8 under the Securities Act of 1933, and
     any amendments or supplements (including post-effective amendments) to such
     Registration Statements; and

To execute and deliver any instruments, certificates or other documents which
     they shall deem necessary or proper in connection with the filing of such
     Registration Statements, and generally to act for and in the name of the
     undersigned with respect to such filings as fully as could the undersigned
     if then personally present and acting.

Each agent named above is hereby empowered to determine in his discretion the
     times when, the purposes for, and the names in which, any power conferred
     upon him herein shall be exercised and the terms and conditions of any
     instrument, certificate or document which may be executed by him pursuant
     to this instrument.

This Power of Attorney shall not be affected by the disability of the
     undersigned or the lapse of time.

The validity, terms and enforcement of this Power of Attorney shall be governed
     by those laws of the State of Ohio that apply to instruments negotiated,
     executed, delivered and performed solely within the State of Ohio.

This Power of Attorney may be executed in any number of counterparts, each of
     which shall have the same effect as if it were the original instrument and
     all of which shall constitute one and the same instrument.

IN WITNESS WHEREOF, I have executed this Power of Attorney this 23rd day of
     January, 1997.


                                             /s/ Michael P. Moore
                                             ---------------------------------
                                                  Michael P. Moore


                                      -15-




<PAGE>   7




                                                                    EXHIBIT 24.1

                                POWER OF ATTORNEY
                            OFFICERS AND DIRECTORS OF
                              NEOPROBE CORPORATION

The undersigned who is a director or officer of Neoprobe Corporation, a
     Delaware corporation (the "company");

Does hereby constitute and appoint John L. Ridihalgh and David C. Bupp to be his
     agents and attorneys-in-fact;

Each with the power to act fully hereunder without the other and with full power
     of substitution to act in the name and on behalf of the undersigned;

To sign and file with the Securities and Exchange Commission one or more
     Registration Statements on Form S-8 under the Securities Act of 1933, and
     any amendments or supplements (including post-effective amendments) to such
     Registration Statements; and

To execute and deliver any instruments, certificates or other documents which
     they shall deem necessary or proper in connection with the filing of such
     Registration Statements, and generally to act for and in the name of the
     undersigned with respect to such filings as fully as could the undersigned
     if then personally present and acting.

Each agent named above is hereby empowered to determine in his discretion the
     times when, the purposes for, and the names in which, any power conferred
     upon him herein shall be exercised and the terms and conditions of any
     instrument, certificate or document which may be executed by him pursuant
     to this instrument.

This Power of Attorney shall not be affected by the disability of the
     undersigned or the lapse of time.

The validity, terms and enforcement of this Power of Attorney shall be governed
     by those laws of the State of Ohio that apply to instruments negotiated,
     executed, delivered and performed solely within the State of Ohio.

This Power of Attorney may be executed in any number of counterparts, each of
     which shall have the same effect as if it were the original instrument and
     all of which shall constitute one and the same instrument.

IN WITNESS WHEREOF, I have executed this Power of Attorney this 23rd day of
     January, 1997.


                                                     /s/ J. Frank Whitley, Jr.
                                                     ---------------------------
                                                          J. Frank Whitley, Jr.


                                      -16-




<PAGE>   8




                                                                    EXHIBIT 24.1

                                POWER OF ATTORNEY
                            OFFICERS AND DIRECTORS OF
                              NEOPROBE CORPORATION

The undersigned who is a director or officer of Neoprobe Corporation, a
     Delaware corporation (the "company");

Does hereby constitute and appoint John L. Ridihalgh and David C. Bupp to be his
     agents and attorneys-in-fact;

Each with the power to act fully hereunder without the other and with full power
     of substitution to act in the name and on behalf of the undersigned;

To sign and file with the Securities and Exchange Commission one or more
     Registration Statements on Form S-8 under the Securities Act of 1933, and
     any amendments or supplements (including post-effective amendments) to such
     Registration Statements; and

To execute and deliver any instruments, certificates or other documents which
     they shall deem necessary or proper in connection with the filing of such
     Registration Statements, and generally to act for and in the name of the
     undersigned with respect to such filings as fully as could the undersigned
     if then personally present and acting.

Each agent named above is hereby empowered to determine in his discretion the
     times when, the purposes for, and the names in which, any power conferred
     upon him herein shall be exercised and the terms and conditions of any
     instrument, certificate or document which may be executed by him pursuant
     to this instrument.

This Power of Attorney shall not be affected by the disability of the
     undersigned or the lapse of time.

The validity, terms and enforcement of this Power of Attorney shall be governed
     by those laws of the State of Ohio that apply to instruments negotiated,
     executed, delivered and performed solely within the State of Ohio.

This Power of Attorney may be executed in any number of counterparts, each of
     which shall have the same effect as if it were the original instrument and
     all of which shall constitute one and the same instrument.

IN WITNESS WHEREOF, I have executed this Power of Attorney this 23rd day of
     January, 1997.


                                                           /s/  James F. Zid
                                                           ---------------------
                                                                 James F. Zid


                                      -17-




<PAGE>   9




                                                                    EXHIBIT 24.1

                                POWER OF ATTORNEY
                            OFFICERS AND DIRECTORS OF
                              NEOPROBE CORPORATION

The undersigned who is a director or officer of Neoprobe Corporation, a
     Delaware corporation (the "company");

Does hereby constitute and appoint John L. Ridihalgh and David C. Bupp to be his
     agents and attorneys-in-fact;

Each with the power to act fully hereunder without the other and with full power
     of substitution to act in the name and on behalf of the undersigned;

To sign and file with the Securities and Exchange Commission one or more
     Registration Statements on Form S-8 under the Securities Act of 1933, and
     any amendments or supplements (including post-effective amendments) to such
     Registration Statements; and

To execute and deliver any instruments, certificates or other documents which
     they shall deem necessary or proper in connection with the filing of such
     Registration Statements, and generally to act for and in the name of the
     undersigned with respect to such filings as fully as could the undersigned
     if then personally present and acting.

Each agent named above is hereby empowered to determine in his discretion the
     times when, the purposes for, and the names in which, any power conferred
     upon him herein shall be exercised and the terms and conditions of any
     instrument, certificate or document which may be executed by him pursuant
     to this instrument.

This Power of Attorney shall not be affected by the disability of the
     undersigned or the lapse of time.

The validity, terms and enforcement of this Power of Attorney shall be governed
     by those laws of the State of Ohio that apply to instruments negotiated,
     executed, delivered and performed solely within the State of Ohio.

This Power of Attorney may be executed in any number of counterparts, each of
     which shall have the same effect as if it were the original instrument and
     all of which shall constitute one and the same instrument.

IN WITNESS WHEREOF, I have executed this Power of Attorney this 23rd day of
     January, 1997.


                                                       /s/  Zwi Vromen
                                                       ------------------------
                                                            Zwi Vromen


                                      -18-





<PAGE>   1




                                                                    EXHIBIT 24.2


                             SECRETARY'S CERTIFICATE


     I, Jerry K. Mueller, Jr., certify that I am the duly elected, qualified and
acting Secretary of Neoprobe Corporation, a Delaware corporation (the
"Corporation"), that I am authorized and empowered to execute this Certificate
on behalf of the Corporation with respect to the Registration Statement on Form
S-8 and further certify that the following is a true, complete and correct copy
of a resolution adopted by the Board of Directors of the Corporation on January
23, 1997, which resolution remains in full force and effect as of the date of
this certificate:

                           RESOLVED, that each representative, officer or
                  director who may be required to execute the Registration
                  Statement and any amendment thereof be, and each of them
                  hereby is, authorized to execute a Power of Attorney
                  appointing John L. Ridihalgh and David C. Bupp as his true and
                  lawful attorney and agent to execute in his name, place and
                  stead (in any capacity) the Registration Statement on Form S-8
                  pertaining to the Restricted Stock Purchase Agreement, as
                  amended, between the Company and Dr. Bianchine, and any
                  amendments thereto, and all instruments necessary or in
                  connection therewith, and to file the same with the
                  Commission, each of which attorney and agent shall have the
                  power to do and perform in the name of and on behalf of each
                  said representative, officer and director, or both, as the
                  case may be, every act whatsoever necessary or advisable to be
                  done in the premises as fully and to all intents and purposes
                  as such representative, officer or director might or could do
                  in person.

     IN WITNESS WHEREOF, I have hereunto set my hand as of January 23, 1997.



                                          /s/   Jerry K. Mueller, Jr.
                                          --------------------------------------
                                                Jerry K. Mueller, Jr., Secretary


                                      -19-






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