NEOPROBE CORP
SC 13D/A, 1998-11-05
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
Previous: STEIN ROE INVESTMENT TRUST, 497, 1998-11-05
Next: PROFESSIONALLY MANAGED PORTFOLIOS, N-30D, 1998-11-05


                   


                                                  ------------------------------
                                                           OMB APPROVAL
                                                  ------------------------------
                                                  OMB Number           3235-0145
                                                  Expires:     December 31, 1997
                                                  Estimated average burden
                                                  hours per response ......14.90
                                                  ------------------------------

                                 UNITED STATES
                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C.  20549

                                 SCHEDULE 13D
             
   
                   Under the Securities Exchange Act of 1934
                               (Amendment No. 4)*
    

                              NEOPROBE CORPORATION
- --------------------------------------------------------------------------------
                                (Name of Issuer)


                         Common Stock, $.001 per share
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)


                                   640518106
- --------------------------------------------------------------------------------
                                 (CUSIP Number)
Mr. Stanley Knowlton                                         John E. Osnato, Esq
Knowlton Brothers, Inc.                                      Kavanagh Maloney &
530 Fifth Avenue                                             Osnato LLP
New York  NY  10036                                          415 Madison Avenue
(212) 764-3602                                               New York, NY  10017
                                                             (212) 207-8400
- --------------------------------------------------------------------------------
                 (Name, Address and Telephone Number of Person
               Authorized to Receive Notices and Communications)


   
                                November 2, 1998
- --------------------------------------------------------------------------------
             (Date of Event which Requires Filing of This Statement)
    

     If the filing  person has  previously  filed a statement on Schedule 13G to
report the acquisition  which is the subject of this Schedule 13D, and is filing
this schedule because of Rule 13d-1(b)(3), or (4), check the following box [_].

Check the following box if a fee is being paid with the statement [_]. (A fee is
not required only if the reporting person:  (1) has a previous statement on file
reporting  beneficial  ownership  of more  htan  five  percent  of the  class of
securities  described  in Item 1;  and (2) has  filed  no  amendment  subsequent
thereto reporitng  beneficial  ownership of five percent or less of such class.)
(See Rule 13d-7)

Note: Six Copies of this statement, including all exhibits, should be filed with
the  Commission.  See Rule  13d-1(a) for other  parties to whom copies are to be
sent.

The  remainder  of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 or  otherwise  subject to the  liabilities  of that  section of the Act but
shall be subject to all other provisions of the Act (however, see the Notes).



                               Page 1 of 36 Pages


<PAGE>


                                  SCHEDULE 13D


CUSIP No.  640518106                                          Page 2 of 36 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSON
     S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON


     The  Family Partnership, L.P.
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     WC   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     Delaware
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
   
  NUMBER OF         0
                    
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         0
                    
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                        
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

   
     0
    

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

   
     0.0%
    

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     PN   

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTESTATION.

<PAGE>


                                  SCHEDULE 13D


CUSIP No.  640518106                                          Page 3 of 36 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSON
     S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON


     The  Frontier Partnership, L.P.
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     WC   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     Delaware
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
   
  NUMBER OF         0
                    
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         0
                    
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                   
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

   
     0
    

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

   
     0.0%
    

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     PN   

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTENTION.

<PAGE>
                                  SCHEDULE 13D


CUSIP No.  640518106                                          Page 4 of 36 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSON
     S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON


     The  Darwin Partnership, L.P
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     WC   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     Delaware
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
  NUMBER OF         232,700
                    
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         232,700
                    
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                    
                    
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     232,700

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     1.01%

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     PN   

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTESTATION.

<PAGE>


CUSIP No.  640518106                                          Page 5 of 36 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSON
     S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON


     The Flagship Partners, Ltd
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     00   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     British Virgin Islands
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
   
  NUMBER OF         0
                   
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         0
                    
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                    
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

   
     0
    

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

   
     0.0%
    

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     CO  

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTESTATION.

<PAGE>


                                  SCHEDULE 13D


CUSIP No.  640518106                                          Page 6 of 36 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSON
     S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON


     Darwin Offshore Partners, Ltd. 
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     WC   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     British Virgin Islands
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
  NUMBER OF         17,800
                    
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         17,800
                    
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                    
                    
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     17,800

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     0.07%

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     CO   

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTESTATION.

<PAGE>


                                  SCHEDULE 13D


CUSIP No.  640518106                                          Page 7 of 36 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSON
     S.S. or S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON


     Barker, Lee & Co., Limited Partnership
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     WC   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     Connecticut
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
  NUMBER OF         152,000
                    
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         152,000
                    
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                    
                    
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     152,000

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     0.66%

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     PN   

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTESTATION.

<PAGE>


                                  SCHEDULE 13D


CUSIP No.  640518106                                          Page 8 of 36 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSON
     S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON


     J.M.R. Barker Foundation
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     WC   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     New York
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
  NUMBER OF         120,400
                    
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         120,400
                    
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                    
                    
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     120,400

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     0.53%

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     CO   

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTESTATION.

<PAGE>


                                  SCHEDULE 13D


CUSIP No.  640518106                                          Page 9 of 36 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSON
     S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON


     Quaker Hill Associates, L.P.
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     WC   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     Delaware
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
  NUMBER OF         36,900
                    
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    36,900
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         
                    
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                    
                    
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     36,900

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     0.16%

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     PN   

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTESTATION.

<PAGE>


                                  SCHEDULE 13D


CUSIP No.  640518106                                         Page 10 of 36 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSON
     S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON


     Upland Associates L.P.
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     WC   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     Delaware
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
  NUMBER OF         86,400
                    
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         86,400
                    
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                    
                    
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     86,400

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     0.38%

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     PN   

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTESTATION.

<PAGE>


                                  SCHEDULE 13D


CUSIP No.  640518106                                         Page 11 of 36 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSON
     S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON


     Namakagon Associates, L.P.
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     WC   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     Delaware
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
  NUMBER OF         229,200
                    
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         229,200
                    
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                    
                    
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     229,200

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     1.01%

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     PN   

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTESTATION.

<PAGE>


                                  SCHEDULE 13D


CUSIP No.  640518106                                         Page 12 of 36 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSON
     S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON


     Family Partners & Co.
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     WC   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     New York
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
  NUMBER OF         
                    
   
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    0
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         
                    
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                    0
    
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

   
     0
    

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

   
     0.0%
    

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     PN   

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTESTATION.

<PAGE>


                                  SCHEDULE 13D


CUSIP No.  640518106                                         Page 13 of 36 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSON
     S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON


     Frontier Partners & Co.
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     WC   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     New York
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
  NUMBER OF         
                    
   
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    0
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         
                    
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                    0
                     
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

   
     0
    

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

   
     0.0%
    

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     PN   

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTESTATION.

<PAGE>


                                  SCHEDULE 13D


CUSIP No.  640518106                                         Page 14 of 36 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSON
     S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON


     Knowlton Brothers, Inc.
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     WC   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     New York
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
  NUMBER OF         
                    
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         
                    
   
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                    17,800
    
                    
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

   
     17,800
    

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

   
     0.07%
    

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     CO   

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTESTATION.

<PAGE>


                                  SCHEDULE 13D


CUSIP No.  640518106                                         Page 15 of 36 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSONS
     S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON


     Knowlton Associates, Inc.
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     WC   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     New York
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
  NUMBER OF         
                    
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         
                    
   
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                    0
    
                    
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

   
     0
    

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

   
     0%
    

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     CO   

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTESTATION.

<PAGE>


                                  SCHEDULE 13D


CUSIP No.  640518106                                         Page 16 of 36 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSON
     S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON


     Hugh Knowlton Trust For The Benefit of Erica Knowlton
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     00   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     New York
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
  NUMBER OF         30,000
                    
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         30,000
                    
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                    
                    
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     30,000

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     0.13%

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     00   

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTESTATION.

<PAGE>


                                  SCHEDULE 13D


CUSIP No.  640518106                                         Page 17 of 36 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSON
     S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON


     Winthrop Knowlton
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     WC   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     USA
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
  NUMBER OF         16,060
                    
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         16,060
                    
   
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                    296,560
    
                    
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

   
     296,560
    

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

   
     1.29%
    

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     IN   

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTESTATION.

<PAGE>


                                  SCHEDULE 13D


CUSIP No.  640518106                                         Page 18 of 36 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSON
     S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON


     Stanley Knowlton
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     WC   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     USA
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
  NUMBER OF         16,900
                    
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         16,900
                    
   
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                    267,400
    
                    
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

   
     267,400
    

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*  [_]
     
       
     
________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

   
     1.17%
    

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     IN   

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTESTATION.

<PAGE>


                                  SCHEDULE 13D


CUSIP No.  640518106                                         Page 19 of 36 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSON
     S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON


     Christopher Knowlton
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     WC   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     USA
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
  NUMBER OF         3,000
                    
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         3,000
                    
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                    235,700
                    
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     235,700

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     1.02%

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     IN   

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTESTATION.

<PAGE>


                                  SCHEDULE 13D


CUSIP No.  640518106                                         Page 20 of 36 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSON
     S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON


     Robert R. Barker
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     WC   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     USA
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
  NUMBER OF         
                    
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         
                    
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                    591,500
                    
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     591,500

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     2.58%

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     IN   

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTESTATION.

<PAGE>


                                  SCHEDULE 13D


CUSIP No.  640518106                                         Page 21 of 36 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSON
     S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON


     Dwight E. Lee
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     WC and PF   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     USA
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
  NUMBER OF         21,800
                    
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         21,800
                    
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                    999,800
                    
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     999,800

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     4.37%

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     IN   

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTESTATION.

<PAGE>
                                                             Page 22 of 36 Pages



   
                         AMENDMENT NO. 4 TO SCHEDULE 13D
    

Item 1.   Security and Issuer

   
     The class of equity  securities  to which this  Amendment No. 4 to Schedule
13D relates is the Common Stock,  $.001 par value  ("Common  Stock") of Neoprobe
Corporation,  a Delaware  corporation (the "Issuer"),  whose principal executive
offices are located at 425 Metro Place North, Suite 400, Dublin,  Ohio 43017. As
a result of the sales of the Common Stock  reported in this Amendment No. 4, the
Reporting  Persons,  as a group and  individually,  ceased to be the  beneficial
owner of 5% or more of the Common Stock on November 2, 1998.
    

Item 2.   Identity and Background

     (a) - (c) and (f).  The  persons  filing  this  statement  are:  The Family
Partnership,  L.P., a Delaware limited  partnership (the "Family  Partnership"),
The Frontier  Partnership,  L.P., a Delaware limited  partnership (the "Frontier
Partnership"), The Darwin Partnership, L.P., a Delaware limited partnership (the
"Darwin  Partnership"),  Flagship  Partners,  Ltd.,  a  British  Virgin  Islands
corporation  ("Flagship"),  Darwin  Offshore  Partners,  Ltd., a British  Virgin
Islands corporation ("Darwin,  Ltd."), Barker, Lee & Co., Limited Partnership, a
Connecticut  limited  partnership  ("Barker,  Lee &  Co."),  the  J.M.R.  Barker
Foundation,  a New York not-for-profit  corporation (the  "Foundation"),  Quaker
Hill Associates, L.P., a Delaware limited partnership ("Quaker Hill"),


<PAGE>


                                                             Page 23 of 36 Pages


   
Upland Associates,  L.P., a Delaware limited partnership  ("Upland"),  Namakagon
Associates, L.P., a Delaware limited partnership ("Namakagon"),  Family Partners
& Co., a New York general  partnership  (the "Family GP"),  Frontier  Partners &
Co., a New York general  partnership  (the "Frontier GP" and,  together with the
Family GP, the "GPs"), Knowlton Brothers,  Inc., a New York corporation ("KBI"),
Knowlton Associates,  Inc., a New York corporation ("KAI"),  Hugh Knowlton Trust
For The Benefit of Erica  Knowlton  (the  "Trust"),  Winthrop  Knowlton  ("WK"),
Stanley Knowlton ("SK"),  Christopher  Knowlton ("CK"),  Robert R. Barker ("RB")
and  Dwight E. Lee  ("DL")  (collectively,  the  "Reporting  Persons").
    

Item 5.   Interest in Securities of the Issuer

   
     (a) The Reporting  Persons own  beneficially an aggregate amount of 963,160
shares of Common Stock,  constituting  approximately  4.21% of the shares of the
Common Stock outstanding, as reflected in information obtained directly from the
Issuer.

     The  Family  Partnership  is no longer  the  beneficial  owner of shares of
Common Stock.  The Frontier  Partnership  is no longer the  beneficial  owner of
shares of Common  Stock.  The  Darwin  Partnership  is the  beneficial  owner of
232,700  shares of Common Stock owned by it directly.  Flagship is no longer the
beneficial owner of shares of Common Stock.  Darwin, Ltd. is the owner of 17,800
shares of Common Stock owned by it directly.  Barker,  Lee & Co. is the owner of
152,000 shares of Common Stock owned by it directly. The Foundation is the owner
of 120,400 shares of Common Stock owned by it directly. Quaker Hill is the owner
of 36,900
    


<PAGE>


                                                             Page 24 of 36 Pages


shares  of  Common  Stock  owned by it  directly.  Upland is the owner of 86,400
shares of Common Stock owned by it  directly.  Namakagon is the owner of 229,200
shares of Common Stock owned by it directly.

   
     The Family GP, the sole general  partner of the Family  Partnership,  is no
longer a beneficial owner of shares of Common Stock.

     The Frontier GP, the sole general partner of the Frontier  Partnership,  is
no longer a beneficial owner of shares of Common Stock.

     KBI may be deemed  to be the  beneficial  owner of 17,800  shares of Common
Stock owned by Darwin,  Ltd.,  because it is the  investment  advisor to Darwin,
Ltd. KBI disclaims beneficial ownership of shares of Common Stock that represent
the interests of the members of Darwin, Ltd.
    

     The Trust is the beneficial owner of 30,000 shares of Common Stock owned by
it directly.

   
     WK may be deemed to be the  beneficial  owner of  296,560  shares of Common
Stock,  (i) 232,700 shares of which are owned by the Darwin  Partnership and may
be  deemed  to be owned by WK  because  he is a general  partner  of the  Darwin
Partnership,  (ii) 17,800 shares of which are owned by Darwin,  Ltd., and may be
deemed  to be  owned  by him  because  he is a  managing  director  of KBI,  the
investment advisor to Darwin Ltd., (iii) 30,000 shares of which are owned by the
Trust and may be deemed to be owned by WK because WK is one of the two  trustees
of the Trust, and (iv) 16,000 shares of
    


<PAGE>


                                                             Page 25 of 36 Pages


   
which are owned directly by WK through an IRA account and 60 shares of which are
owned  directly  by  WK in  his  individual  account.  WK  disclaims  beneficial
ownership of those shares of Common Stock which  represent  the interests of the
other  partners  of the Darwin  Partnership,  the  interests  of the  members of
Darwin, Ltd., and the interests of the Trust.

     SK may be deemed to be the  beneficial  owner of  267,400  shares of Common
Stock,  (i) 232,700 shares of which are owned by the Darwin  Partnership and may
be  deemed  to be owned by SK  because  he is a general  partner  of the  Darwin
Partnership,  (ii) 17,800 shares of which are owned by Darwin,  Ltd., and may be
deemed  to be  owned  by him  because  he is a  managing  director  of KBI,  the
investment  advisor  to Darwin,  Ltd.,  (iii)  16,700  shares of which are owned
directly  by SK in his own  account  and  through an IRA  account,  and (iv) 200
shares of which are owned by Calvin Fowler Knowlton,  his son, and may be deemed
to be  owned  by him  because  they  are  held in an  account  over  which he is
custodian.  SK  disclaims  beneficial  ownership of those shares of Common Stock
which  represent the interests of the members of Darwin,  Ltd., and those shares
owned by his son.
    

     CK may be deemed to be the  beneficial  owner of  235,700  shares of Common
Stock,  (i) 232,700 shares of which are owned by the Darwin  Partnership and may
be  deemed  to be owned by CK  because  he is a general  partner  of the  Darwin
Partnership,  and (ii) 3,000 shares of which are owned directly by CK through an
IRA account. CK disclaims beneficial ownership of those shares of Common Stock


<PAGE>


                                                             Page 26 of 36 Pages


which represent the interests of the other partners of the Darwin Partnership.

     RB may be deemed to be the  beneficial  owner of  591,500  shares of Common
Stock, (i) 471,100 shares of which are owned by the Darwin Partnership,  Barker,
Lee & Co. and Upland and may be deemed to be owned by RB because he is a general
partner of each such entity,  and (ii) 120,400  shares of which are owned by the
Foundation  and may be deemed to be owned by RB because he is the  President  of
the  Foundation.  RB  disclaims  beneficial  ownership of those shares of Common
Stock  which  represent  the  interests  of the  other  partners  of the  Darwin
Partnership,  Barker, Lee & Co. and Upland and all of the shares of Common Stock
owned by Foundation.

     DL may be deemed to be the  beneficial  owner of  999,800  shares of Common
Stock, (i) 857,600 shares of which are owned by the Darwin Partnership,  Barker,
Lee & Co., Quaker Hill, Upland and Namakagon and may be deemed to be owned by DL
because he is a general  partner of each such  entity,  (ii)  120,400  shares of
which are owned by the Foundation and may be deemed to be owned by DL because he
is a Vice  President  of the  Foundation,  and  (iii)  21,800 of which are owned
directly by DL through IRA accounts.  DL disclaims beneficial ownership of those
shares of Common Stock which  represent the  interests of the other  partners of
the Darwin Partnership, Barker, Lee & Co., Quaker Hill, Upland and Namakagon and
all of the shares of Common Stock owned by the Foundation.

     (b) See pages 2 through 21 of this Schedule 13D.


<PAGE>


                                                             Page 27 of 36 Pages


   
     (c) Within the period from  September 7, 1998 through the date hereof,  the
Reporting Persons purchased shares of Common Stock and Warrants on the dates, in
the amounts and at the prices per share set forth on Schedule 1 attached  hereto
and  incorporated  by reference  herein.  All such  purchases  were made through
NASDAQ.

     (e) The Reporting  Persons,  as a group and individually,  ceased to be the
beneficial  owner of 5% or more of the Common Stock on November 2, 1998.
    

Item 7.   Materials to be Filed as Exhibits

   
     Exhibit A -- Joint Filing Agreement, dated November 2, 1998.
    


<PAGE>


                                                             Page 28 of 36 Pages


                                   SIGNATURES

     After  reasonable  inquiry and to the best of our knowledge and belief,  we
certify that the information  set forth in this statement is true,  complete and
correct.

   
Dated:  November 2, 1998
    


THE FRONTIER PARTNERSHIP, L.P.                    THE FAMILY PARTNERSHIP, L.P.

By: Frontier Partners & Co.,                      By: Family Partners & Co.,
      as general partner                                as general partner

   By: Knowlton Brothers, Inc.,                     By: Knowlton Brothers, Inc.,
        as general partner                                as general partner


By:  /s/ Stanley Knowlton                         By:  /s/ Stanley Knowlton    
     --------------------                              --------------------    
      Name: Stanley Knowlton                            Name: Stanley Knowlton
      Title: President                                  Title: President


THE DARWIN PARTNERSHIP, L.P.                      DARWIN OFFSHORE PARTNERS, LTD.

                                                  By: Knowlton Brothers, Inc.,
By:  /s/ Stanley Knowlton                                as Investment Advisor
    --------------------                                
      Name: Stanley Knowlton
      Title: General Partner
                                                  By:  /s/ Stanley Knowlton     
                                                        --------------------    
                                                        Name: Stanley Knowlton
                                                        Title: President
BARKER, LEE & CO.             
                              
By:  /s/ Dwight E. Lee                            QUAKER HILL ASSOCIATES, L.P.
     -----------------        
      Name: Dwight E. Lee                         By:  /s/ Dwight E. Lee        
      Title: General Partner                           -----------------        
                                                        Name: Dwight E. Lee
                                                        Title: General Partner
J.M.R. BARKER FOUNDATION      
                              
By:  /s/ Dwight E. Lee        
     -----------------        
      Name: Dwight E. Lee     
      Title: Vice President   



<PAGE>


                                                             Page 29 of 36 Pages


UPLAND ASSOCIATES, L.P.                           NAMAKAGON ASSOCIATES, L.P.


By:  /s/ Dwight E. Lee                             By:  /s/ Dwight E. Lee       
     --------------------------                       -------------------------
      Name: Dwight E. Lee                                Name: Dwight E. Lee
      Title: General Partner                             Title: General Partner



FLAGSHIP PARTNERS, LTD.                           FAMILY PARTNERS & CO.

By: Knowlton Brothers, Inc.,                      By: Knowlton Brothers, Inc.,
      as Investment Advisor                             as general partner


By:  /s/ Stanley Knowlton                         By:   /s/ Stanley Knowlton    
     -------------------------                         -------------------------
      Name: Stanley Knowlton                             Name: Stanley Knowlton
      Title: President                                   Title: President



FRONTIER PARTNERS & CO.                           KNOWLTON BROTHERS, INC.

By: Knowlton Brothers, Inc.,
      as general partner                          By:   /s/ Winthrop Knowlton   
                                                       -------------------------
                                                         Name: Winthrop Knowlton
                                                         Title: Chairman
By:  /s/ Winthrop Knowlton    
     -------------------------
      Name: Winthrop Knowlton
      Title: Chairman                                   /s/ Winthrop Knowlton   
                                                       -------------------------
                                                            WINTHROP KNOWLTON
KNOWLTON ASSOCIATES, INC.

                                                        /s/ Christopher Knowlton
                                                       -------------------------
By:  /s/ Winthrop Knowlton                                  CHRISTOPHER KNOWLTON
     -------------------------
      Name: Winthrop Knowlton
      Title: Chairman

                                                        /s/ Robert R. Barker    
                                                       -------------------------
     /s/ Stanley Knowlton                                   ROBERT R. BARKER
     -------------------------
         STANLEY KNOWLTON


     /s/ Dwight E. Lee                            HUGH KNOWLTON TRUST FOR THE
     -------------------------                    BENEFIT OF ERICA KNOWLTON
         DWIGHT E. LEE                           



                                                  By:   /s/ Winthrop Knowlton   
                                                       -------------------------
                                                         Name: Winthrop Knowlton
                                                         Title: Trustee

<PAGE>

                                                             Page 30 of 36 Pages


   
                                   SCHEDULE 1
    

                          Transactions in Common Stock
                                of Neoprobe Corp.
                         Effected Since October 14, 1998

                          THE FAMILY PARTNERSHIP, L.P.

                                 No. of Shares                  Cost (Sales
                                of Common Stock                 Price) Per
Trade Date                           Sold                         Share
- ----------                      ---------------                 -----------
       
 10/28/98                           26,000                        $ 1.26
 10/29/98                           13,000                        $ 1.20
 10/30/98                            8,400                        $ 1.21
 10/30/98                            5,000                        $ 1.21
 10/30/98                            2,000                        $ 1.21
 10/30/98                            4,000                        $ 1.21
 10/30/98                            5,000                        $ 1.21
 10/30/98                            8,000                        $ 1.21
 10/30/98                            5,000                        $ 1.21
 10/30/98                            6,000                        $ 1.21
 10/30/98                            2,000                        $ 1.21
 10/30/98                            9,000                        $ 1.21
 10/30/98                           23,000                        $ 1.21
 10/30/98                            8,000                        $ 1.21
 10/30/98                            6,200                        $ 1.21
 11/2/98                             3,800                        $ 1.31
 11/2/98                             4,000                        $ 1.31
 11/2/98                             4,000                        $ 1.31
 11/2/98                             5,000                        $ 1.31
 11/2/98                            10,000                        $ 1.31
 11/2/98                             6,000                        $ 1.31
 11/2/98                            10,000                        $ 1.31
 11/2/98                             9,000                        $ 1.31
 11/2/98                             6,000                        $ 1.31
 11/2/98                             1,000                        $ 1.31
 11/2/98                            24,000                        $ 1.31
 11/2/98                             5,000                        $ 1.31
 11/2/98                             9,000                        $ 1.31
 11/2/98                             1,000                        $ 1.31



<PAGE>


                                                             Page 31 of 36 Pages


                         THE FRONTIER PARTNERSHIP, L.P.

                                 No. of Shares                  Cost (Sales
                                of Common Stock                 Price) Per
Trade Date                           Sold                         Share
- ----------                      ---------------                 -----------
       
 10/28/98                            6,900                        $ 1.26
 10/28/98                            5,000                        $ 1.26
 10/28/98                            3,000                        $ 1.26
 10/28/98                            2,000                        $ 1.26
 10/29/98                            2,000                        $ 1.20
 10/28/98                            6,000                        $ 1.20
 10/29/98                            2,000                        $ 1.20
 10/30/98                            1,000                        $ 1.21
 10/30/98                            6,000                        $ 1.21
 10/30/98                            2,000                        $ 1.21
 10/30/98                            2,000                        $ 1.21
 10/30/98                            8,000                        $ 1.21
 10/30/98                           26,000                        $ 1.21
 10/30/98                            8,000                        $ 1.21
 10/30/98                           10,000                        $ 1.21
 10/30/98                            3,300                        $ 1.21
 11/2/98                               700                        $ 1.31
 11/2/98                             4,000                        $ 1.31
 11/2/98                             6,000                        $ 1.31
 11/2/98                             5,000                        $ 1.31
 11/2/98                             7,000                        $ 1.31
 11/2/98                             3,000                        $ 1.31
 11/2/98                             5,000                        $ 1.31
 11/2/98                             8,000                        $ 4.31
 11/2/98                             4,000                        $ 1.31
 11/2/98                               500                        $ 1.31
 11/2/98                            19,000                        $ 1.31
 11/2/98                             4,000                        $ 1.31
 11/2/98                             7,000                        $ 1.31
 11/2/98                             1,000                        $ 1.31


                             FLAGSHIP PARTNERS, LTD.

                                 No. of Shares                  Cost (Sales
                                of Common Stock                 Price) Per
Trade Date                           Sold                          Share
- ----------                      ---------------                 -----------
       
 10/28/98                            3,500                        $ 1.26
 10/28/98                            3,000                        $ 1.26
 10/28/98                              600                        $ 1.26
 10/29/98                            2,400                        $ 1.20
 10/29/98                            1,000                        $ 1.20
 10/29/98                            2,600                        $ 1.20
 10/30/98                              400                        $ 1.21


<PAGE>


                                                             Page 32 of 36 Pages


 10/30/98                            2,000                        $ 1.21
 10/30/98                            2,000                        $ 1.21
 10/30/98                            1,000                        $ 1.21
 10/30/98                            3,000                        $ 1.21
 10/30/98                            7,000                        $ 1.21
 10/30/98                            3,000                        $ 1.21
 10/30/98                            5,000                        $ 1.21
 10/30/98                            2,000                        $ 1.21
 10/30/98                            2,000                        $ 1.21
 10/30/98                            2,000                        $ 1.21
 10/30/98                            3,000                        $ 1.21
 10/30/98                            1,000                        $ 1.21
 10/30/98                            3,000                        $ 1.21
 10/30/98                            3,000                        $ 1.21
 10/30/98                              500                        $ 1.21
 10/30/98                            5,400                        $ 1.21
 11/2/98                             2,600                        $ 1.31
 11/2/98                             1,000                        $ 1.31
 11/2/98                            10,000                        $ 1.31
 11/2/98                            12,000                        $ 1.31
 11/2/98                             3,000                        $ 1.31
 11/2/98                             1,000                        $ 1.31



<PAGE>


                                                             Page 33 of 36 Pages



                                    EXHIBIT A

                             JOINT FILING AGREEMENT

     The Family Partnership,  L.P., The Frontier  Partnership,  L.P., The Darwin
Partnership,  L.P.,  Flagship Partners,  Ltd., Darwin Offshore  Partners,  Ltd.,
Barker, Lee & Co., the J.M.R. Barker Foundation,  Quaker Hill Associates,  L.P.,
Upland  Associates,  L.P.,  Namakagon  Associates,  L.P., Family Partners & Co.,
Frontier Partners & Co., Knowlton Brothers,  Inc.,  Knowlton  Associates,  Inc.,
Hugh  Knowlton  Trust For The  Benefit  of Erica  Knowlton,  Winthrop  Knowlton,
Stanley Knowlton,  Christopher Knowlton, Robert R. Barker and Dwight E. Lee each
hereby  agree that the Schedule 13D filed  herewith and any  amendments  thereto
relating to the acquisition of shares of Common Stock of Neoprobe Corporation is
filed jointly on behalf of each such person.

   
Dated: November 2, 1998
    


                                                 THE FAMILY PARTNERSHIP, L.P.

                                                 By: Family Partners & Co.,
                                                       as general partner

                                                    By: Knowlton Brothers, Inc.,
                                                          as general partner


                                                 By: /s/ Stanley Knowlton       
                                                     ---------------------------
                                                      Name: Stanley Knowlton
                                                      Title: President


<PAGE>


                                                             Page 34 of 36 Pages


                                                  THE FRONTIER PARTNERSHIP, L.P.

                                                  By: Frontier Partners & Co.,
                                                         as general partner

                                                    By: Knowlton Brothers, Inc.,
                                                           as general partner


                                                  By:  /s/ Stanley Knowlton     
                                                       -------------------------
                                                        Name: Stanley Knowlton
                                                        Title: President


                                                  THE DARWIN PARTNERSHIP, L.P.


                                                  By:  /s/ Stanley Knowlton     
                                                       -------------------------
                                                        Name: Stanley Knowlton
                                                        Title: General Partner


                                                  BARKER, LEE & CO.


                                                  By:  /s/ Dwight E. Lee        
                                                       -------------------------
                                                        Name: Dwight E. Lee
                                                        Title: General Partner


                                                  J.M.R. BARKER FOUNDATION


                                                  By:  /s/ Dwight E. Lee        
                                                       -------------------------
                                                        Name: Dwight E. Lee
                                                        Title: Vice President


                                                  QUAKER HILL ASSOCIATES, L.P.


                                                  By:  /s/ Dwight E. Lee        
                                                       -------------------------
                                                        Name: Dwight E. Lee
                                                        Title: General Partner


                                                  UPLAND ASSOCIATES, L.P.


                                                  By:  /s/ Dwight E. Lee        
                                                       -------------------------
                                                        Name: Dwight E. Lee
                                                        Title: General Partner


<PAGE>


                                                             Page 35 of 36 Pages


                                            NAMAKAGON ASSOCIATES, L.P.

                                            By:  /s/ Dwight E. Lee          
                                                 ---------------------------
                                                  Name: Dwight E. Lee
                                                  Title: General Partner


                                            FLAGSHIP PARTNERS, LTD.

                                            By: Knowlton Brothers, Inc.,
                                                  as Investment Advisor


                                            By:  /s/ Stanley Knowlton       
                                                 ---------------------------
                                                  Name: Stanley Knowlton
                                                  Title: President


                                            DARWIN OFFSHORE PARTNERS, LTD.

                                            By: Knowlton Brothers, Inc.,
                                                  as Investment Advisor


                                            By:  /s/ Stanley Knowlton       
                                                 ---------------------------
                                                  Name: Stanley Knowlton
                                                  Title: President


                                            FAMILY PARTNERS & CO.

                                            By: Knowlton Brothers, Inc.,
                                                  as general partner


                                            By:  /s/ Stanley Knowlton       
                                                 ---------------------------
                                                  Name: Stanley Knowlton
                                                  Title: President


                                            FRONTIER PARTNERS & CO.

                                            By: Knowlton Brothers, Inc.,
                                                  as general partner


                                            By:  /s/ Winthrop Knowlton      
                                                 ---------------------------
                                                  Name: Winthrop Knowlton
                                                  Title: Chairman





<PAGE>


                                                             Page 36 of 36 Pages


                                            KNOWLTON BROTHERS, INC.


                                            By:  /s/ Winthrop Knowlton    
                                                 ------------------------- 
                                                  Name: Winthrop Knowlton
                                                  Title: Chairman



                                            KNOWLTON ASSOCIATES, INC.


                                            By:  /s/ Winthrop Knowlton    
                                                 ------------------------- 
                                                  Name: Winthrop Knowlton
                                                  Title: Chairman



                                            HUGH KNOWLTON TRUST FOR THE
                                            BENEFIT OF ERICA KNOWLTON


                                            By:  /s/ Winthrop Knowlton    
                                                 -------------------------
                                                  Name: Winthrop Knowlton
                                                  Title: Trustee


                                                 /s/ Winthrop Knowlton    
                                                 -------------------------
                                                     WINTHROP KNOWLTON


                                                 /s/ Stanley Knowlton     
                                                 -------------------------
                                                     STANLEY KNOWLTON


                                                 /s/ Christopher Knowlton 
                                                 -------------------------
                                                     CHRISTOPHER KNOWLTON


                                                 /s/ Robert R. Barker     
                                                 -------------------------
                                                     ROBERT R. BARKER


                                                 /s/ Dwight E. Lee        
                                                 -------------------------
                                                     DWIGHT E. LEE



© 2022 IncJournal is not affiliated with or endorsed by the U.S. Securities and Exchange Commission