NEOPROBE CORP
SC 13D/A, 1998-10-19
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                                 UNITED STATES
                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C.  20549

                                 SCHEDULE 13D
             
                   Under the Securities Exchange Act of 1934
                               (Amendment No. 3)*

                              NEOPROBE CORPORATION
- --------------------------------------------------------------------------------
                                (Name of Issuer)


                         Common Stock, $.001 per share
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)


                                   640518106
- --------------------------------------------------------------------------------
                                 (CUSIP Number)
Mr. Stanley Knowlton                                         John E. Osnato, Esq
Knowlton Brothers, Inc.                                      Kavanagh Maloney &
530 Fifth Avenue                                             Osnato LLP
New York  NY  10036                                          415 Madison Avenue
(212) 764-3602                                               New York, NY  10017
                                                             (212) 207-8400
- --------------------------------------------------------------------------------
                 (Name, Address and Telephone Number of Person
               Authorized to Receive Notices and Communications)


                                October 14, 1998
- --------------------------------------------------------------------------------
             (Date of Event which Requires Filing of This Statement)

     If the filing  person has  previously  filed a statement on Schedule 13G to
report the acquisition  which is the subject of this Schedule 13D, and is filing
this schedule because of Rule 13d-1(b)(3), or (4), check the following box [_].

Check the following box if a fee is being paid with the statement [_]. (A fee is
not required only if the reporting person:  (1) has a previous statement on file
reporting  beneficial  ownership  of more  htan  five  percent  of the  class of
securities  described  in Item 1;  and (2) has  filed  no  amendment  subsequent
thereto reporitng  beneficial  ownership of five percent or less of such class.)
(See Rule 13d-7)

Note: Six Copies of this statement, including all exhibits, should be filed with
the  Commission.  See Rule  13d-1(a) for other  parties to whom copies are to be
sent.

The  remainder  of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 or  otherwise  subject to the  liabilities  of that  section of the Act but
shall be subject to all other provisions of the Act (however, see the Notes).


                               Page 1 of 37 Pages

<PAGE>


                                  SCHEDULE 13D


CUSIP No.  640518106                                          Page 2 of 37 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSONS
     S.S. or I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)


     The  Family Partnership, L.P.
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     WC   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     Delaware
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
  NUMBER OF         234,400
                    
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         234,400
                    
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                    
                    
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     234,400

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     1.02%

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     PN   

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTESTATION.

<PAGE>


                                  SCHEDULE 13D


CUSIP No.  640518106                                          Page 3 of 37 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSONS
     S.S. or I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)


     The  Frontier Partnership, L.P.
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     WC   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     Delaware
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
  NUMBER OF         167,400
                    
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         167,400
                    
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                    
                    
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     167,400

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     0.73%

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     PN   

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTENTION.

<PAGE>
                                  SCHEDULE 13D


CUSIP No.  640518106                                          Page 4 of 37 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSONS
     S.S. or I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)


     The  Darwin Partnership, L.P
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     WC   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     Delaware
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
  NUMBER OF         232,700
                    
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         232,700
                    
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                    
                    
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     232,700

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     1.01%

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     PN   

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTESTATION.

<PAGE>


CUSIP No.  640518106                                          Page 5 of 37 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSONS
     S.S. or I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)


     The Flagship Partners, Ltd
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     00   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     British Virgin Islands
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
  NUMBER OF         90,000
                    
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         90,000
                    
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                    
                    
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     90,000

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     0.39%

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     CO  

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTESTATION.

<PAGE>


                                  SCHEDULE 13D


CUSIP No.  640518106                                          Page 6 of 37 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSONS
     S.S. or I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)


     Darwin Offshore Partners, Ltd. 
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     WC   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     British Virgin Islands
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
  NUMBER OF         17,800
                    
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         17,800
                    
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                    
                    
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     17,800

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     0.07%

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     CO   

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTESTATION.

<PAGE>


                                  SCHEDULE 13D


CUSIP No.  640518106                                          Page 7 of 37 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSONS
     S.S. or S.S. or I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)


     Barker, Lee & Co., Limited Partnership
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     WC   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     Connecticut
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
  NUMBER OF         152,000
                    
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         152,000
                    
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                    
                    
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     152,000

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     0.66%

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     PN   

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTESTATION.

<PAGE>


                                  SCHEDULE 13D


CUSIP No.  640518106                                          Page 8 of 37 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSONS
     S.S. or I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)


     J.M.R. Barker Foundation
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     WC   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     New York
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
  NUMBER OF         120,400
                    
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         120,400
                    
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                    
                    
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     120,400

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     0.53%

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     CO   

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTESTATION.

<PAGE>


                                  SCHEDULE 13D


CUSIP No.  640518106                                          Page 9 of 37 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSONS
     S.S. or I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)


     Quaker Hill Associates, L.P.
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     WC   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     Delaware
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
  NUMBER OF         36,900
                    
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    36,900
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         
                    
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                    
                    
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     36,900

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     0.16%

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     PN   

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTESTATION.

<PAGE>


                                  SCHEDULE 13D


CUSIP No.  640518106                                         Page 10 of 37 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSONS
     S.S. or I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)


     Upland Associates L.P.
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     WC   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     Delaware
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
  NUMBER OF         86,400
                    
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         86,400
                    
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                    
                    
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     86,400

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     0.38%

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     PN   

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTESTATION.

<PAGE>


                                  SCHEDULE 13D


CUSIP No.  640518106                                         Page 11 of 37 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSONS
     S.S. or I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)


     Namakagon Associates, L.P.
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     WC   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     Delaware
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
  NUMBER OF         229,200
                    
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         229,200
                    
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                    
                    
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     229,200

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     1.01%

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     PN   

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTESTATION.

<PAGE>


                                  SCHEDULE 13D


CUSIP No.  640518106                                         Page 12 of 37 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSONS
     S.S. or I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)


     Family Partners & Co.
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     WC   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     New York
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
  NUMBER OF         
                    
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    234,400
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         
                    
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                    234,400
                    
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     234,400

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     1.02%

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     PN   

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTESTATION.

<PAGE>


                                  SCHEDULE 13D


CUSIP No.  640518106                                         Page 13 of 37 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSONS
     S.S. or I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)


     Frontier Partners & Co.
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     WC   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     New York
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
  NUMBER OF         
                    
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    167,400
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         
                    
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                    167,400
                    
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     167,400

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     0.73%

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     PN   

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTESTATION.

<PAGE>


                                  SCHEDULE 13D


CUSIP No.  640518106                                         Page 14 of 37 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSONS
     S.S. or I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)


     Knowlton Brothers, Inc.
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     WC   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     New York
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
  NUMBER OF         
                    
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         
                    
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                    509,600
                    
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     509,600

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     2.22%

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     CO   

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTESTATION.

<PAGE>


                                  SCHEDULE 13D


CUSIP No.  640518106                                         Page 15 of 37 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSONS
     S.S. or I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)


     Knowlton Associates, Inc.
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     WC   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     New York
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
  NUMBER OF         
                    
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         
                    
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                    167,400
                    
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     167,400

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     0.73%

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     CO   

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTESTATION.

<PAGE>


                                  SCHEDULE 13D


CUSIP No.  640518106                                         Page 16 of 37 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSONS
     S.S. or I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)


     Hugh Knowlton Trust For The Benefit of Erica Knowlton
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     00   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     New York
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
  NUMBER OF         30,000
                    
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         30,000
                    
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                    
                    
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     30,000

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     0.13%

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     00   

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTESTATION.

<PAGE>


                                  SCHEDULE 13D


CUSIP No.  640518106                                         Page 17 of 37 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSONS
     S.S. or I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)


     Winthrop Knowlton
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     WC   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     USA
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
  NUMBER OF         16,060
                    
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         16,060
                    
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                    788,360
                    
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     788,360

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     3.44%

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     IN   

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTESTATION.

<PAGE>


                                  SCHEDULE 13D


CUSIP No.  640518106                                         Page 18 of 37 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSONS
     S.S. or I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)


     Stanley Knowlton
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     WC   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     USA
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
  NUMBER OF         16,900
                    
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         16,900
                    
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                    759,200
                    
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     759,200

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*  [_]
     The aggregate amount in row (11) excludes shares deemed to be held by 
     Stanley Knowlton's wife                                                    

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     3.31%

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     IN   

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTESTATION.

<PAGE>


                                  SCHEDULE 13D


CUSIP No.  640518106                                         Page 19 of 37 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSONS
     S.S. or I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)


     Christopher Knowlton
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     WC   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     USA
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
  NUMBER OF         3,000
                    
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         3,000
                    
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                    235,700
                    
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     235,700

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     1.02%

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     IN   

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTESTATION.

<PAGE>


                                  SCHEDULE 13D


CUSIP No.  640518106                                         Page 20 of 37 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSONS
     S.S. or I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)


     Robert R. Barker
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     WC   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     USA
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
  NUMBER OF         
                    
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         
                    
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                    591,500
                    
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     591,500

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     2.58%

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     IN   

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTESTATION.

<PAGE>


                                  SCHEDULE 13D


CUSIP No.  640518106                                         Page 21 of 37 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSONS
     S.S. or I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)


     Dwight E. Lee
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [X]
                                                                 (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*


     WC and PF   
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION


     USA
________________________________________________________________________________
               7    SOLE VOTING POWER
                    
  NUMBER OF         21,800
                    
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY        
                    
  OWNED BY          
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER
                    
  REPORTING         21,800
                    
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH            
                    999,800
                    
________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     999,800

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     4.37%

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     IN   

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
        (INCLUDING EXHIBITS) OF THE SCHEDULE AND THE SIGNATURE ATTESTATION.

<PAGE>


                                                             Page 22 of 37 Pages



                         AMENDMENT NO. 3 TO SCHEDULE 13D

Item 1. Security and Issuer
     
   
     The class of equity  securities  to which this  Amendment No. 3 to Schedule
13D relates is the Common Stock,  $.001 par value  ("Common  Stock") of Neoprobe
Corporation,  a Delaware  corporation (the "Issuer"),  whose principal executive
offices are located at 425 Metro Place North, Suite 400, Dublin, Ohio 43017.
    

     Item 2. Identity and Background

   
     (a) - (c) and (f).  The  persons  filing  this  statement  are:  The Family
Partnership,  L.P., a Delaware limited  partnership (the "Family  Partnership"),
The Frontier  Partnership,  L.P., a Delaware limited  partnership (the "Frontier
Partnership"), The Darwin Partnership, L.P., a Delaware limited partnership (the
"Darwin  Partnership"),  Flagship  Partners,  Ltd.,  a  British  Virgin  Islands
corporation  ("Flagship"),  Darwin  Offshore  Partners,  Ltd., a British  Virgin
Islands corporation ("Darwin,  Ltd."), Barker, Lee & Co., Limited Partnership, a
Connecticut  limited  partnership  ("Barker,  Lee &  Co."),  the  J.M.R.  Barker
Foundation,  a New York not-for-profit  corporation (the  "Foundation"),  Quaker
Hill Associates,  L.P., a Delaware limited partnership  ("Quaker Hill"),  Upland
Associates,   L.P.  a  Delaware  limited   partnership   ("Upland"),   Namakagon
Associates, L.P., a Delaware limited partnership ("Namakagon"),  Family Partners
& Co., a New York general  partnership  (the "Family GP"),  Frontier  Partners &
Co., a New York
    


<PAGE>

                                                             Page 23 of 37 Pages

   
general  partnership  (the  "Frontier GP" and,  together with the Family GP, the
"GPs"),  Knowlton  Brothers,  Inc.,  a New York  corporation  ("KBI"),  Knowlton
Associates,  Inc., a New York corporation  ("KAI"),  Hugh Knowlton Trust For The
Benefit of Erica  Knowlton (the  "Trust"),  Winthrop  Knowlton  ("WK"),  Stanley
Knowlton ("SK"), Christopher Knowlton ("CK"), Robert R. Barker ("RB") and Dwight
E. Lee ("DL") (collectively,  the "Reporting  Persons").  Attached as Schedule 1
and  incorporated by reference is a table setting forth changes in the executive
officers and directors of each Reporting Person that is a corporation  since the
last filing. 
    

       

Item 5. Interest in Securities of the Issuer

   
     (a) The Reporting Persons own beneficially an aggregate amount of 1,454,960
shares of Common Stock,  constituting  approximately  6.36% of the shares of the
Common Stock outstanding, as reflected in information obtained directly from the
Issuer.

     The Family  Partnership is the beneficial owner of 234,400 shares of Common
Stock owned by it directly.  The Frontier Partnership is the beneficial owner of
167,400 shares of Common Stock owned by it directly.  The Darwin  Partnership is
the  beneficial  owner of 232,700  shares of Common  Stock owned by it directly.
Flagship is the  beneficial  owner of 90,000  shares of Common Stock owned by it
directly. Darwin, Ltd. is the owner of 17,800 shares of Common Stock owned by it
directly. Barker, Lee & Co. is the owner of 152,000 shares of Common Stock owned
by it directly.  The  Foundation is the owner of 120,400  shares of Common Stock
owned by it directly. Quaker Hill is the owner of 36,900
    


<PAGE>


                                                             Page 24 of 37 Pages


   
shares  of  Common  Stock  owned by it  directly.  Upland is the owner of 86,400
shares of Common Stock owned by it  directly.  Namakagon is the owner of 229,200
shares of Common Stock owned by it directly.

     The Family GP, the sole general partner of the Family  Partnership,  may be
deemed to be the  beneficial  owner of all the  234,400  shares of Common  Stock
owned by the Family Partnership. The Family GP disclaims beneficial ownership of
those  shares of Common  Stock  that  represent  the  interests  of the  limited
partners of the Family Partnership.

     The Frontier GP, the sole general partner of the Frontier Partnership,  may
be deemed to be the  beneficial  owner of all the 167,400 shares of Common Stock
owned  by  the  Frontier  Partnership.  The  Frontier  GP  disclaims  beneficial
ownership of those shares of Common Stock that  represent  the  interests of the
limited partners of the Frontier Partnership.

     KBI may be deemed to be the  beneficial  owner of 509,600  shares of Common
Stock.  KBI may be deemed to be the beneficial owner of (i) 401,800 shares owned
by the  Family  Partnership  and the  Frontier  Partnership  because  it jointly
controls  the GPs,  (ii)  90,000  shares  owned by  Flagship  because  it is the
investment  advisor to Flagship,  and (iii) 17,800  shares owed by Darwin,  Ltd.
because it is the investment  advisor to Darwin,  Ltd. KBI disclaims  beneficial
ownership of those shares of Common Stock that  represent the interest of KAI in
the Frontier GP, the interests of the limited partners of the Family Partnership
and the Frontier
    


<PAGE>


                                                             Page 25 of 37 Pages


   
Partnership,  the  interests of the members of Flagship and the interests of the
members of Darwin, Ltd.

     KAI may be deemed to be the  beneficial  owner of 167,400  shares of Common
Stock which are owned by the Frontier  Partnership  because it jointly  controls
the Frontier GP. KAI  disclaims  beneficial  ownership of those shares of Common
Stock that represent the interest of KBI in the Frontier GP and the interests of
the limited partners of the Frontier Partnership.

     The Trust is the beneficial owner of 30,000 shares of Common Stock owned by
it directly.

     WK may be deemed to be the  beneficial  owner of  788,360  shares of Common
Stock,  (i) 401,800 shares of which are owned by the Family  Partnership and the
Frontier  Partnership  and may be deemed to be owned by WK  because  he  jointly
controls  the GPs,  (ii)  232,700  shares  of  which  are  owned  by the  Darwin
Partnership  and may be deemed to be owned by WK because he is a general partner
of the Darwin  Partnership,  (iii) 107,800 shares of which are owned by Flagship
and Darwin,  Ltd.  and may be deemed to be owned by him because he is a managing
director of KBI, the investment advisor to Flagship and Darwin Ltd., (iv) 30,000
shares  of which  are  owned by the  Trust  and may be  deemed to be owned by WK
because WK is one of the two  trustees  of the Trust,  and (v) 16,000  shares of
which are owned directly by WK through an IRA account and 60 shares of which are
owned  directly  by  WK in  his  individual  account.  WK  disclaims  beneficial
ownership of those shares of Common Stock which  represent  the interests of the
other partners of the Family
    


<PAGE>


                                                             Page 26 of 37 Pages


   
Partnership,  the Frontier Partnership and the Darwin Partnership, the interests
of the members of Flagship and Darwin, Ltd. and the interests of the Trust.

     SK may be deemed to be the  beneficial  owner of  759,200  shares of Common
Stock,  (i) 401,800 shares of which are owned by the Family  Partnership and the
Frontier  Partnership  and may be deemed to be owned by SK  because  he  jointly
controls  the GPs,  (ii)  232,700  shares  of  which  are  owned  by the  Darwin
Partnership  and may be deemed to be owned by SK because he is a general partner
of the Darwin  Partnership,  (iii) 107,800 shares of which are owned by Flagship
and Darwin,  Ltd.  and may be deemed to be owned by him because he is a managing
director of KBI,  the  investment  advisor to Flagship  and Darwin,  Ltd.,  (iv)
16,700  shares of which are owned  directly by SK in his own account and through
an IRA account, and (v) 200 shares of which are owned by Calvin Fowler Knowlton,
his  son,  and may be  deemed  to be owned  by him  because  they are held in an
account over which he is custodian.  The amount of beneficial ownership reported
with  respect to SK on row (11) of Page No. 18 excludes  shares of Common  Stock
deemed to be owned by  Margaret  Knowlton,  his wife,  by virtue of her  limited
partnership  interest  in  the  Family  Partnership.   SK  disclaims  beneficial
ownership of those shares of Common Stock which  represent  the interests of the
other  partners of the Family  Partnership,  the  Frontier  Partnership  and the
Darwin Partnership the interests of the members of Flagship and Darwin, Ltd. and
those shares owned by his son.
    


<PAGE>


                                                             Page 27 of 37 Pages


   
     CK may be deemed to be the  beneficial  owner of  235,700  shares of Common
Stock,  (i) 232,700 shares of which are owned by the Darwin  Partnership and may
be  deemed  to be owned by CK  because  he is a general  partner  of the  Darwin
Partnership,  and (ii) 3,000 shares of which are owned directly by CK through an
IRA account. CK disclaims  beneficial  ownership of those shares of Common Stock
which represent the interests of the other partners of the Darwin Partnership.

     RB may be deemed to be the  beneficial  owner of  591,500  shares of Common
Stock, (i) 471,100 shares of which are owned by the Darwin Partnership,  Barker,
Lee & Co. and Upland and may be deemed to be owned by RB because he is a general
partner of each such entity,  and (ii) 120,400  shares of which are owned by the
Foundation  and may be deemed to be owned by RB because he is the  President  of
the  Foundation.  RB  disclaims  beneficial  ownership of those shares of Common
Stock  which  represent  the  interests  of the  other  partners  of the  Darwin
Partnership,  Barker, Lee & Co. and Upland and all of the shares of Common Stock
owned by Foundation.

     DL may be deemed to be the  beneficial  owner of  999,800  shares of Common
Stock, (i) 857,600 shares of which are owned by the Darwin Partnership,  Barker,
Lee & Co., Quaker Hill, Upland and Namakagon and may be deemed to be owned by DL
because he is a general  partner of each such  entity,  (ii)  120,400  shares of
which are owned by the Foundation and may be deemed to be owned by DL because he
is a Vice  President  of the  Foundation,  and  (iii)  21,800 of which are owned
directly by DL through IRA accounts. DL
    


<PAGE>


                                                             Page 28 of 37 Pages


   
disclaims  beneficial  ownership of those shares of Common Stock which represent
the interests of the other  partners of the Darwin  Partnership,  Barker,  Lee &
Co.,  Quaker Hill,  Upland and  Namakagon  and all of the shares of Common Stock
owned by the Foundation.
    

     (b) See pages 2 through 21 of this Schedule 13D.
  
   
     (c) Within the period  from August 15, 1998  through the date  hereof,  the
Reporting Persons purchased shares of Common Stock and Warrants on the dates, in
the amounts and at the prices per share set forth on Schedule 2 attached  hereto
and  incorporated  by reference  herein.  All such  purchases  were made through
NASDAQ.
    

       

Item 7. Materials to be Filed as Exhibits

   
        Exhibit A -- Joint Filing Agreement, dated October 16, 1998.
    

       

<PAGE>


                                                             Page 29 of 37 Pages


                                   SIGNATURES


     After  reasonable  inquiry and to the best of our knowledge and belief,  we
certify that the information  set forth in this statement is true,  complete and
correct. 

   
Dated: October 16, 1998
    

THE FRONTIER PARTNERSHIP, L.P.                    THE FAMILY PARTNERSHIP, L.P.

By: Frontier Partners & Co.,                      By: Family Partners & Co.,
      as general partner                                as general partner

   By: Knowlton Brothers, Inc.,                     By: Knowlton Brothers, Inc.,
        as general partner                                as general partner


   
By:  /s/ Stanley Knowlton                         By:  /s/ Stanley Knowlton    
     --------------------                              --------------------    
      Name: Stanley Knowlton                            Name: Stanley Knowlton
      Title: President                                  Title: President

THE DARWIN PARTNERSHIP, L.P.                      DARWIN OFFSHORE PARTNERS, LTD.

                                                  By: Knowlton Brothers, Inc.,
By:  /s/ Stanley Knowlton                                as Investment Advisor
    --------------------                                
      Name: Stanley Knowlton
      Title: General Partner
                                                  By:  /s/ Stanley Knowlton     
                                                        --------------------    
                                                        Name: Stanley Knowlton
                                                        Title: President
    

BARKER, LEE & CO.                                 QUAKER HILL ASSOCIATES, L.P.

   
By:  /s/ Dwight E. Lee                            By:  /s/ Dwight E. Lee        
     -----------------                                 -----------------        
      Name: Dwight E. Lee                               Name: Dwight E. Lee
      Title: General Partner                            Title: General Partner
    

J.M.R. BARKER FOUNDATION



   
By:  /s/ Dwight E. Lee       
     -----------------       
      Name: Dwight E. Lee
      Title: Vice President
    


<PAGE>


                                                             Page 30 of 37 Pages


UPLAND ASSOCIATES, L.P.                           NAMAKAGON ASSOCIATES, L.P.



   
By:  /s/ Dwight E. Lee                             By:  /s/ Dwight E. Lee       
     --------------------------                       -------------------------
      Name: Dwight E. Lee                                Name: Dwight E. Lee
      Title: General Partner                             Title: General Partner
    


FLAGSHIP PARTNERS, LTD.                           FAMILY PARTNERS & CO.

By: Knowlton Brothers, Inc.,                      By: Knowlton Brothers, Inc.,
      as Investment Advisor                             as general partner


   
By:  /s/ Stanley Knowlton                         By:   /s/ Stanley Knowlton    
     -------------------------                         -------------------------
      Name: Stanley Knowlton                             Name: Stanley Knowlton
      Title: President                                   Title: President
    

FRONTIER PARTNERS & CO.                           KNOWLTON BROTHERS, INC.

   
By: Knowlton Brothers, Inc.,
      as general partner                          By:   /s/ Winthrop Knowlton   
                                                       -------------------------
                                                         Name: Winthrop Knowlton
                                                         Title: Chairman
By:  /s/ Winthrop Knowlton    
     -------------------------
      Name: Winthrop Knowlton
      Title: Chairman                                   /s/ Winthrop Knowlton   
                                                       -------------------------
                                                            WINTHROP KNOWLTON
KNOWLTON ASSOCIATES, INC.

                                                        /s/ Christopher Knowlton
                                                       -------------------------
By:  /s/ Winthrop Knowlton                                  CHRISTOPHER KNOWLTON
     -------------------------
      Name: Winthrop Knowlton
      Title: Chairman

                                                        /s/ Robert R. Barker    
                                                       -------------------------
     /s/ Stanley Knowlton                                   ROBERT R. BARKER
     -------------------------
         STANLEY KNOWLTON


     /s/ Dwight E. Lee                            HUGH KNOWLTON TRUST FOR THE
     -------------------------                    BENEFIT OF ERICA KNOWLTON
         DWIGHT E. LEE                           



                                                  By:   /s/ Winthrop Knowlton   
                                                       -------------------------
                                                         Name: Winthrop Knowlton
                                                         Title: Trustee
    


<PAGE>


                                                             Page 31 of 37 Pages


                                   SCHEDULE 1

   
                                   CHANGES TO
                    LIST OF DIRECTORS AND EXECUTIVE OFFICERS
    


         Name, Position and                             Principal
         Business Address*                              Occupation or Employment

A.   KNOWLTON BROTHERS, INC.

   
         New Officers:

         Christopher Knowlton
         Vice President
         c/o Knowlton Brothers, Inc.
         530 Fifth Avenue
         New York NY 10036-3101
    

       

   
B.   J.M.R. BARKER FOUNDATION

         No longer Officers or Directors
    

         Elizabeth S. Barker

       

   
         New Officers or Directors

         Margaret S. Barker                             Computer Software
         Director (U.S.A.)
         11310 Spicewood Club Drive #19
         Austin TX 78750-2868


- ----------
    *    Each director and executive  officer listed herein is a citizen of the
         United States of America.
    


<PAGE>


                                                             Page 32 of 37 Pages


                                   SCHEDULE 2

   
                          Transactions in Common Stock
                                of Neoprobe Corp.
                         Effected Since August 15, 1998

                          THE FAMILY PARTNERSHIP, L.P.
    

       

   
                                No. of Shares                        Cost (Sales
                                of Common Stock                      Price) Per
Trade Date                      Sold                                 Share      
- ----------                      ---------------                      -----------

8/18/98                            2,000                               $ 1.29
 9/9/98                            1,000                               $ 1.01
9/21/98                            5,500                               $ 0.93
9/21/98                           10,000                               $ 0.93
9/21/98                              500                               $ 0.93
9/22/98                            5,000                               $ 0.93
9/23/98                           10,000                               $ 0.86
9/24/98                            4,500                               $ 0.85
9/24/98                            2,500                               $ 0.85
9/25/98                            5,000                               $ 0.85
9/28/98                            3,000                               $ 0.85
9/29/98                            4,000                               $ 0.89
9/30/98                            3,600                               $ 0.93
10/1/98                            4,500                               $ 0.09
    

                         THE FRONTIER PARTNERSHIP, L.P.

   
                                No. of Shares                        Cost (Sales
                                of Common Stock                      Price) Per
Trade Date                      Sold                                 Share      
    

       

   
8/19/98                            2,500                               $ 1.29
8/19/98                              500                               $ 1.29
 9/1/98                            5,000                               $ 0.99
 9/3/98                            4,500                               $ 1.01
 9/3/98                              500                               $ 1.01
 9/8/98                            3,000                               $ 1.00
9/21/98                            6,500                               $ 0.93
9/21/98                            6,700                               $ 0.93
9/22/98                            4,000                               $ 0.93
9/23/98                            6,500                               $ 0.86
9/24/98                            4,400                               $ 0.85
9/25/98                            4,000                               $ 0.85
9/28/98                            2,000                               $ 0.85
9/29/98                            3,000                               $ 0.89
9/30/98                            2,000                               $ 0.93
10/1/98                            3,500                               $ 0.90
10/8/98                           12,000                               $ 0.60
10/9/98                            5,000                               $ 0.60
    


<PAGE>


                                                             Page 33 of 37 Pages


                             FLAGSHIP PARTNERS, LTD.
                             -----------------------

   
                                 No. of Shares                       Cost (Sales
                                 of Common Stock                     Price) Per
Trade Date                       Sold                                Share      
    

       


   
8/19/98                             1,500                                $ 1.29
8/19/98                             3,500                                $ 1.29
9/21/98                             1,500                                $ 0.93
9/21/98                             5,500                                $ 0.93
9/22/98                             1,000                                $ 0.93
9/23/98                             3,000                                $ 0.86
9/24/98                             2,000                                $ 0.85
9/25/98                             1,000                                $ 0.85
9/28/98                             1,000                                $ 0.85
9/29/98                             1,000                                $ 0.89
9/30/98                             1,000                                $ 0.93
10/1/98                             1,000                                $ 0.90
10/2/98                             3,500                                $ 0.85
10/2/98                             1,500                                $ 0.85
    


<PAGE>


                                                             Page 34 of 37 Pages


                                    EXHIBIT A

                             JOINT FILING AGREEMENT

   
     The Family Partnership,  L.P., The Frontier  Partnership,  L.P., The Darwin
Partnership,  L.P.,  Flagship Partners,  Ltd., Darwin Offshore  Partners,  Ltd.,
Barker, Lee & Co., the J.M.R. Barker Foundation,  Quaker Hill Associates,  L.P.,
Upland  Associates,  L.P.,  Namakagon  Associates,  L.P., Family Partners & Co.,
Frontier Partners & Co., Knowlton Brothers,  Inc.,  Knowlton  Associates,  Inc.,
Hugh  Knowlton  Trust For The  Benefit  of Erica  Knowlton,  Winthrop  Knowlton,
Stanley Knowlton,  Christopher Knowlton, Robert R. Barker and Dwight E. Lee each
hereby  agree that the Schedule 13D filed  herewith and any  amendments  thereto
relating to the acquisition of shares of Common Stock of Neoprobe Corporation is
filed jointly on behalf of each such person.

Dated: October 16, 1998
    


                                                 THE FAMILY PARTNERSHIP, L.P.

                                                 By: Family Partners & Co.,
                                                       as general partner

                                                    By: Knowlton Brothers, Inc.,
                                                          as general partner


   
                                                 By: /s/ Stanley Knowlton       
                                                     ---------------------------
                                                      Name: Stanley Knowlton
                                                      Title: President
    


<PAGE>


                                                             Page 35 of 37 Pages


                                                  THE FRONTIER PARTNERSHIP, L.P.

                                                  By: Frontier Partners & Co.,
                                                         as general partner

                                                    By: Knowlton Brothers, Inc.,
                                                           as general partner


   
                                                  By:  /s/ Stanley Knowlton     
                                                       -------------------------
                                                        Name: Stanley Knowlton
                                                        Title: President

                                                  THE DARWIN PARTNERSHIP, L.P.


                                                  By:  /s/ Stanley Knowlton     
                                                       -------------------------
                                                        Name: Stanley Knowlton
                                                        Title: General Partner

                                                  BARKER, LEE & CO.



                                                  By:  /s/ Dwight E. Lee        
                                                       -------------------------
                                                        Name: Dwight E. Lee
                                                        Title: General Partner

                                                  J.M.R. BARKER FOUNDATION



                                                  By:  /s/ Dwight E. Lee        
                                                       -------------------------
                                                        Name: Dwight E. Lee
                                                        Title: Vice President

                                                  QUAKER HILL ASSOCIATES, L.P.


                                                  By:  /s/ Dwight E. Lee        
                                                       -------------------------
                                                        Name: Dwight E. Lee
                                                        Title: General Partner

                                                  UPLAND ASSOCIATES, L.P.


                                                  By:  /s/ Dwight E. Lee        
                                                       -------------------------
                                                        Name: Dwight E. Lee
                                                        Title: General Partner
    


<PAGE>


                                                             Page 36 of 37 Pages


                                            NAMAKAGON ASSOCIATES, L.P.


   
                                            By:  /s/ Dwight E. Lee          
                                                 ---------------------------
                                                  Name: Dwight E. Lee
                                                  Title: General Partner
    

                                            FLAGSHIP PARTNERS, LTD.

                                            By: Knowlton Brothers, Inc.,
                                                  as Investment Advisor

   
                                            By:  /s/ Stanley Knowlton       
                                                 ---------------------------
                                                  Name: Stanley Knowlton
                                                  Title: President
    

                                            DARWIN OFFSHORE PARTNERS, LTD.

                                            By: Knowlton Brothers, Inc.,
                                                  as Investment Advisor

   
                                            By:  /s/ Stanley Knowlton       
                                                 ---------------------------
                                                  Name: Stanley Knowlton
                                                  Title: President
    

                                            FAMILY PARTNERS & CO.

                                            By: Knowlton Brothers, Inc.,
                                                  as general partner

   
                                            By:  /s/ Stanley Knowlton       
                                                 ---------------------------
                                                  Name: Stanley Knowlton
                                                  Title: President
    

                                            FRONTIER PARTNERS & CO.

                                            By: Knowlton Brothers, Inc.,
                                                  as general partner

   
                                            By:  /s/ Winthrop Knowlton      
                                                 ---------------------------
                                                  Name: Winthrop Knowlton
                                                  Title: Chairman
    




<PAGE>


                                                             Page 37 of 37 Pages


                                            KNOWLTON BROTHERS, INC.


   
                                            By:  /s/ Winthrop Knowlton    
                                                 ------------------------- 
                                                  Name: Winthrop Knowlton
                                                  Title: Chairman
    


                                            KNOWLTON ASSOCIATES, INC.

   
                                            By:  /s/ Winthrop Knowlton    
                                                 ------------------------- 
                                                  Name: Winthrop Knowlton
                                                  Title: Chairman
    


                                            HUGH KNOWLTON TRUST FOR THE
                                            BENEFIT OF ERICA KNOWLTON

   
                                            By:  /s/ Winthrop Knowlton    
                                                 -------------------------
                                                  Name: Winthrop Knowlton
                                                  Title: Trustee


                                                 /s/ Winthrop Knowlton    
                                                 -------------------------
                                                     WINTHROP KNOWLTON


                                                 /s/ Stanley Knowlton     
                                                 -------------------------
                                                     STANLEY KNOWLTON


                                                 /s/ Christopher Knowlton 
                                                 -------------------------
                                                     CHRISTOPHER KNOWLTON


                                                 /s/ Robert R. Barker     
                                                 -------------------------
                                                     ROBERT R. BARKER


                                                 /s/ Dwight E. Lee        
                                                 -------------------------
                                                     DWIGHT E. LEE
    




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