APPLIED BIOSCIENCE INTERNATIONAL INC
10-K/A, 1995-05-05
TESTING LABORATORIES
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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C.  20549
                                    ________

                                   FORM 10-K/A
                                 AMENDMENT NO. 1

(Mark One)
[X]  ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE
     ACT OF 1934 [FEE REQUIRED]

     For the fiscal year ended December 31, 1994.

[ ]  TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
     EXCHANGE ACT OF 1934 [NO FEE REQUIRED]

     For the transition period from ________ to ________
                         Commission file number 0-15515

                      APPLIED BIOSCIENCE INTERNATIONAL INC.
                      -------------------------------------
             (Exact name of registrant as specified in its charter)


                    Delaware                        22-2734293
                    --------                        ----------
          (State or other jurisdiction           (I.R.S. employer
               of incorporation or             identification no.)
                  organization)

            4350 North Fairfax Drive
               Arlington, Virginia                  22203-1627
               -------------------                  ----------
              (Address of principal                 (Zip code)
               executive offices)

Registrant's telephone number, including area code:  (703) 516-2490
                                                     --------------
Securities registered pursuant to Section 12(b) of the Act:  None
                                                             ----

Securities registered pursuant to Section 12(g) of the Act:


                     Common Stock, par value $.01 per share
                     --------------------------------------
                                (Title of class)

     Indicate by check mark whether the registrant: (1) has filed all reports
required to be filed by Section 13 or 15(d) of the Securities Exchange Act of
1934 during the preceding 12 months (or for such shorter period that the
registrant was required to file such reports), and (2) has been subject to such
filing requirements for the past 90 days.  Yes  X  No _____
                                               ---

     Indicate by check mark if disclosure of delinquent filers pursuant to Item
405 of Regulation S-K is not contained herein, and will not be contained, to the
best of the registrant's knowledge, in definitive proxy or information
statements incorporated by reference in Part III of this Form 10-K or any
amendment to this Form 10-K.  ____

     The aggregate market value of the voting stock held by non-affiliates of
the registrant was $136,888,940, as of March 15, 1995.

     The number of shares outstanding of the registrant's class of common stock,
par value $.01 per share, was 28,173,470 as of March 15, 1995.


<PAGE>

     The Form 10-K for the year ended December 31, 1994 of Applied Bioscience
International Inc. (the "Company") is being amended to (i) revise Item No. 4 of
Part I, (ii) substitute information relating to Mr. Stephen L. Waechter for
information relating to Dr. Geoffrey K. Hogan in Item No. 11 of Part III, (iii)
delete information relating to the beneficial ownership of the Company's Common
Stock by Dr. Geoffrey K. Hogan in Item No. 12 of Part III and (iv) include two
letter agreements between the Company and Mr. Stephen L. Waechter as Exhibits
10.32 and 10.33 in Item No. 14 of Part IV.

                                     PART I
Item 4.   Submission of Matters to a Vote of Security Holders

          (a)  The Company held its Annual Meeting of Stockholders on
               October 21, 1994.

          (b)  Not applicable.

          (c)  The sole matter voted upon at the Company's Annual Meeting of
               Stockholders was the election of Dr. Joseph H. Highland, Dr.
               Geoffrey K. Hogan, Mr. Steven A. Fleckman and Mr. Frank E. Loy as
               directors.  The results of the election were as follows:



                                                                  ABSTENTION OR
             NOMINEE                FOR             AGAINST      BROKER NON-VOTE
             -------                ---             -------      ---------------
  Dr. Joseph H. Highland         22,692,531         199,796             0

  Dr. Geoffrey K. Hogan          21,074,008       1,818,319             0

  Mr. Steven A. Fleckman         22,688,915         203,412             0

  Mr. Frank E. Loy               22,689,967         202,360             0



                                    PART III

Item 11.  Executive Compensation.

Summary of Cash and Certain Other Compensation


     The following table sets forth the cash compensation paid by the Company
and its subsidiaries for or with respect to the fiscal years ended December 31,
1992, 1993 and 1994, to each of the five most highly compensated executive
officers of the Company, including the Chief Executive Officer, during fiscal
year 1994, for all capacities in which they served.



                                      -1-
<PAGE>

<TABLE><CAPTION>
                                        SUMMARY COMPENSATION TABLE
                                        --------------------------
                                                                                    LONG TERM
                                                                                  COMPENSATION
                                                                                  ------------
                                                 ANNUAL COMPENSATION                 AWARDS
                                                 -------------------                 ------


                                                               Other              Securities            All Other
                                        Salary      Bonus       Annual            Underlying          Compensation
 Name and Principal Postion     Year      $        ($)(1)   Compensation($)   Options/SARs(#)(2)          ($)(3)
 --------------------------     ----    ------     ------   ---------------   ------------------      ------------
<S>                             <C>    <C>        <C>       <C>               <C>                     <C>
 Grover C. Wrenn (4)            1994   $198,625   $  --             $  --            50,000               $ 22,645
 President and Chief            1993    181,500      --                --            52,000                 19,858
 Executive Officer              1992    181,500      --                --                --                100,729


 Swep T. Davis (5)              1994    200,000   100,000              --            67,000                  8,456
 President of APBI              1993    200,000    28,125              --                --                  5,842
 Environmental                  1992     23,288        --              --           100,000                  5,034
 Sciences Group


 Charles L. Defesche            1994    229,828        --              --           134,010                 11,488
 (6) President and              1993    225,000        --              --                --                 29,814
 Chief Executive                1992    205,303   278,050              --           170,076                 26,319
 Officer of Pharmaco 
 LSR International, Inc.


 Joseph H. Highland             1994    211,667   150,000              --             8,000                 25,183
 Chief Executive                1993    200,000    60,889              --             6,666                 18,673
 Officer of the                 1992    177,513        --              --                --                 20,842
 ENVIRON division of
 APBI Environmental 
 Sciences Group, Inc.


 Stephen L. Waechter            1994    163,125    25,000              --            20,000                  5,051
 (7) Senior Vice                1993     48,513    15,000              --            24,000                  1,292
 President, Chief               1992         --        --              --                --                     --
 Financial Officer
 and Treasurer
- ----------------------
</TABLE>


                                                                -2-


<PAGE>

(1)  With the exception of Mr. Waechter's bonus amounts, the annual bonus
     amounts with respect to fiscal years 1994 and 1993 were determined under
     the Company's Economic Value Added ("EVA") compensation program.  Dr.
     Defesche did not earn a bonus under the EVA program in 1994 and 1993.  Mr.
     Wrenn did not earn a bonus under the EVA program in 1993 and his bonus for
     1994 has not been determined.  Mr. Waechter received a signing bonus of
     $15,000 when he joined the Company in September 1993 and was guaranteed a
     minimum cash bonus of $25,000 for fiscal year 1994, which was slightly
     higher than the bonus Mr. Waechter would otherwise have received under the
     Company's EVA compensation program.

(2)  With respect to the options awarded in fiscal year 1994 to Mr. Davis and
     Dr. Defesche, (i) the options to acquire 67,000 shares of Common Stock
     awarded to Mr. Davis were in substitution for the options to acquire
     100,000 shares of Common Stock awarded to Mr. Davis in fiscal year 1992 and
     (ii) the options to acquire 134,010 shares of Common Stock awarded to Dr.
     Defesche consisted of options to acquire 104,010 shares of Common Stock
     awarded to Dr. Defesche in  substitution for the options to acquire 170,076
     shares of Common Stock awarded to Dr. Defesche in fiscal year 1992 and
     options to acquire 30,000 shares of Common Stock awarded to Dr. Defesche
     under the Company's annual compensation program.

(3)  The total amounts shown in the "All Other Compensation" column with respect
     to fiscal year 1994 consist of the following:  (i) $12,624 in matching
     Company contributions to the APBI Environmental Sciences Group, Inc.
     Pension Plan, a money purchase pension plan, on behalf of Mr. Wrenn, $1,803
     represents the taxable benefit to Mr. Wrenn of premiums paid by the Company
     for group term life insurance on his behalf, $3,718 represents the taxable
     benefit to Mr. Wrenn of premiums paid by the Company for key man life
     insurance on his behalf, and $4,500 in matching Company contributions to
     the APBI U.S. Retirement 401(k) Savings Plan, a defined contribution plan,
     on behalf of Mr. Wrenn; (ii) $1,218 represents the taxable benefit to Mr.
     Davis of premiums paid by the Company for group term life insurance on his
     behalf, $2,738 represents the premiums paid by the Company for keyman life
     insurance on his behalf and $4,500 in matching Company contributions to the
     APBI U.S. Retirement 401(k) Savings Plan, a defined contribution plan, on
     behalf of Mr. Davis; (iii) $522 represents the taxable benefit to Dr.
     Defesche of premiums paid by the Company for group term life insurance on
     his behalf, $8,274 represents payment for unused vacation benefits  and
     $2,692 in matching Company contributions to the APBI U.S. Retirement 401(k)
     Savings Plan, a defined contribution plan, on behalf of Dr. Defesche;
     (iv) $2,016 represents the taxable benefit to Dr. Highland of premiums paid
     by the Company for group term life insurance on his behalf, $4,500 in
     matching Company contributions to the APBI U.S. Retirement 401(k) Savings
     Plan, a defined contribution plan, on behalf of Dr. Highland, $5,064
     represents the premiums paid by the Company for keyman life insurance on
     his behalf and $13,603 in Company contributions to the APBI Environmental
     Sciences Group, Inc. Pension Plan, a money purchase pension plan, on behalf
     of Dr. Highland; (v)  $551 represents the taxable benefit to Mr. Waechter
     of premiums paid by the Company for group term life insurance on his behalf
     and $4,500 in matching Company contributions to the APBI U.S. Retirement
     401(k) Savings Plan, a defined contribution plan, on behalf of Mr.
     Waechter.

(4)  Mr. Wrenn served as the President and Chief Executive Officer of the
     Company until February 1995.  Mr. Wrenn continues to serve as a director of
     the Company.

(5)  Mr. Davis joined the Company in November 1992 as President of APBI
     Environmental Sciences Group, Inc. and continued to serve as such until
     January 31, 1995.  Mr. Davis continues to serve as a director of APBI.


                                       -3-


<PAGE>

(6)  Dr. Defesche served as the President and Chief Executive Officer of
     Pharmaco LSR until February 1995.  Mr. Defesche continues to serve as
     chairman of Pharmaco LSR and as a director of the Company.

(7)  Mr. Waechter joined the Company in September 1993 as the Chief Financial
     Officer and Treasurer of the Company.  In October 1994, he also became a
     Senior Vice President of the Company.


                                       -4-


<PAGE>

Stock Option Grants in Fiscal 1994

     The following table sets forth certain information concerning the grant of
stock options made under the Company's Stock Incentive Program (1990) during the
fiscal year ended December 31, 1994 to each of the executive officers of the
Company named in the Summary Compensation Table.


<TABLE><CAPTION>
                                       OPTION GRANTS IN LAST FISCAL YEAR(1)

                                                                                           Grant Date
                                                  INDIVIDUAL GRANTS                           Value  
                            -----------------------------------------------------------    ----------




                                             Percent of
                              Number of         Total
                             Securities        Options
                             Underlying      Granted to
                               Options      Employees in    Exercise or                     Grant Date
                               Granted      Fiscal Year      Base Price     Expiration     Present Value
           Name                 (#)              (2)           ($/Sh)           Date          ($)(3)
           ----              ----------     ------------    -----------     ----------     -----------
<S>                          <C>            <C>             <C>             <C>            <C>
  Grover C. Wrenn             50,000(4)          5.8           $5.875         9/13/04       $203,000

  Swep T. Davis               67,000(5)          7.8            7.00          4/13/04        265,990

  Charles L. Defesche        104,010(5)         12.1            7.00          4/13/04        412,920

                              30,000(4)          3.5            5.875         9/13/04        121,800

  Joseph H. Highland           8,000(4)          0.9            5.875         9/13/04         32,480

  Stephen L. Waechter         20,000(4)          2.3            5.875         9/13/04         81,200

- ----------------------

</TABLE>

(1)  The Company's stock option plans are administered by the Compensation and
     Stock Plans Committee of the Board of Directors.  The exercise price per
     share of all of the options granted during fiscal year 1994 is equal to or
     greater than the fair market value per share of the Company's Common Stock
     on the date of the grant, and the options are exercisable over a term of
     ten years from the date of grant. 

(2)  The Company granted options to employees to acquire 858,320 shares of
     Common Stock during fiscal year 1994.  The 1994 option grants include
     options to acquire 481,320 shares of Common Stock which were granted
     pursuant to the Company's 1994 replacement program, whereby the Company
     reduced the exercise price of certain previously issued options to a price
     closer to the current fair market values of the Company's Common Stock. 
     The replacement program resulted in the cancellation of options to acquire
     892,480 shares of Common Stock.

(3)  The "Grant Date Present Value" is a hypothetical value determined under the
     Black-Scholes Option Pricing Model.  It is one of the methods permitted by
     the Securities and Exchange Commission for estimating the present value of
     options.  The Company's stock options are not transferable, and the actual
     value of the stock options that an executive officer


                                       -5-


<PAGE>

     may realize, if any, will depend on the excess of the market price on the
     date of exercise over the exercise price.  The Black-Scholes Option Pricing
     Model is based on assumptions as to certain variables such as the
     volatility of the Company's stock price and prevailing interest rates, so
     there is no assurance that any individual will actually realize the option
     values presented in this table.  The Company has based its assumption for
     stock price volatility on the variance of closing prices for the Company's
     stock for the five years prior to the grant date of the option award.  In
     addition, the pricing model assumes (i) a risk-free rate of return equal to
     the rate of return for ten-year U.S. Government obligations on the grant
     date, (ii) no future dividend payments and (iii) that all options will be
     held for full ten-year terms.

(4)  These options were granted on September 13, 1994 and vest ratably over a
     three-year period on the anniversary of the date of grant.

(5)  The options were granted on April 13, 1994 pursuant to the Company's 1994
     option replacement program and vest ratably over a four-year period on the
     anniversary of the date of grant.


                                       -6-


<PAGE>

Option Exercises and Holdings

     No stock options held by any director or officer of the Company were
exercised during the 1994 fiscal year.  The following table sets forth
information as of December 31, 1994, regarding the number and value of options
held by each of the executive officers of the Company named in the Summary
Compensation Table.  None of the named executive officers held any stock
appreciation rights ("SARs") as of such date.

<TABLE><CAPTION>
                 AGGREGATED OPTION/SAR EXERCISES IN LAST FISCAL
                 ----------------------------------------------
                      AND FISCAL YEAR-END OPTION/SAR VALUES
                      -------------------------------------

                              Number of Securities Underlying            Value of Unexercised in-the-Money
                                Unexercised Options/SARs at             Options/SARs at Fiscal Year-End(1)
                                      Fiscal Year-End(#)                                ($)
                                ---------------------------            -----------------------------------

            Name              Exercisable       Unexercisable       Exercisable       Unexercisable
            ----              -----------       -------------       -----------       -------------
<S>                           <C>               <C>                 <C>               <C>
  Grover C. Wrenn                54,761             92,667              $ --               $ --

  Swep T. Davis                    --               67,000                --                 --

  Charles L. Defesche              --              134,010                --                 --

  Joseph H. Highland             39,650             20,444                --                 --

  Stephen L. Waechter             8,000             36,600                --                 --

- ---------------------
</TABLE>

(1)  Based on the closing price per share of the Company's Common Stock of $5.50
     on the National Association of Securities Dealers Automated Quotation
     National Market System on December 31, 1994.  


                                       -7-


<PAGE>

Item 12.  Security Ownership of Certain Beneficial Owners and Management.

     The following table sets forth information regarding the beneficial
ownership of the Company's Common Stock as of March 15, 1995 by (i) each person
who was known by the Company to own beneficially more than five percent (5%) of
the Company's Common Stock then outstanding, (ii) each director of the Company
and each of the executive officers of the Company named in the Summary
Compensation Table, and (iii) all directors and executive officers of the
Company as a group. Unless otherwise indicated, each of the directors, executive
officers and stockholders listed below, and the directors and executive officers
as a group, have sole voting power and sole investment power with respect to the
shares beneficially owned by them.


<TABLE><CAPTION>
                                                                                   Common Stock of the Company,
                                                                                     par value $.01 per share
                                                                                 ---------------------------------
                                                     Amount and Nature of
 Name of Beneficial Owner                            Beneficial Ownership                  Percent of Class
 ------------------------                            --------------------                  ----------------
<S>                                                  <C>                                   <C>
General American Investors Company, Inc.(1)               2,220,513                              7.9%
Merrill Lynch & Co., Inc.(2)                              2,347,100                              8.3
Pioneering Management Corporation(3)                      1,540,800                              5.5
State of Wisconsin Investment Board(4)                    2,800,000                              9.9
Richard J. Hawkins(5)                                     2,278,313                              8.1
Kenneth H. Harper(6)                                        529,220                              1.8
Stephen L. Waechter(7)                                       12,855                               *
Swep T. Davis(8)                                             21,250                               *
Charles L. Defesche(9)                                       26,052                               *
Steven A. Fleckman                                              ---                              ---
Frederick Frank                                                 ---                              ---
Joseph H. Highland(10)                                      606,944                              2.2
Frank E. Loy                                                  4,500                               *
Thomas J. Russell                                               ---                              ---
John H. Timoney(11)                                         198,223                               *
Grover C. Wrenn(12)                                         903,247                              3.2
All directors and executive officers as a group
 (13 persons)(13)                                         2,340,268                              8.1

- ----------------------------
*         Represents less than 1%.
</TABLE>


(1)  Based on information contained in a Schedule 13G filed with the Securities
     and Exchange Commission on February 10, 1995.  Includes 809,032 shares over
     which General American Investors Company, Inc. shares voting and investment
     power with General American Advisers, Inc.  The address of  General
     American Investors Company, Inc. is 450 Lexington Avenue, New York, New
     York 10017.


                                       -8-


<PAGE>

(2)  Based on information contained in a Schedule 13G filed with the Securities
     and Exchange Commission on February 9, 1995.  Consists of shares over which
     Merrill  Lynch & Co., Inc., Merrill Lynch Group, Inc. and Princeton
     Services, Inc. may be deemed to exercise shared voting and investment
     authority.  Merrill Lynch & Co., Inc.,  Merrill Lynch Group, Inc. and
     Princeton Services, Inc. disclaim beneficial ownership of such shares.  
     The address of Merrill Lynch & Co., Inc. and Merrill Lynch Group, Inc. is
     World Financial Center, North Tower, 250 Vesey Street, New York, New York
     10281.  The address of Princeton Services, Inc. is 800 Scudders Mill Road,
     Plainsboro, New Jersey 08536.

(3)  Based on information contained in a Schedule 13G filed with the Securities
     and Exchange Commission on January 25, 1995.  The address of Pioneering
     Management Corporation is 60 State Street, Boston, Massachusetts 02114.

(4)  Based on information contained in a Schedule 13G filed with the Securities
     and Exchange Commission on February 13, 1995. The address of the State of
     Wisconsin Investment Board is P.O. Box 7842,  Madison, Wisconsin 53707.

(5)  Based on information contained in a Schedule 13D filed with the Securities
     and Exchange Commission on April 27, 1994.  Mr. Hawkins' address is 324
     Eanes School Road, Austin, Texas 78746.  Includes 1,189,799 shares owned by
     Mr. Hawkins' wife, as to which Mr. Hawkins does not disclaim beneficial
     ownership.

(6)  Includes 529,220 shares which may be acquired within the next 60 days
     pursuant to the exercise of options granted under the Company's Stock
     Incentive Program (1990).

(7)  Includes 4,000 shares owned jointly by Mr. Waechter and his wife and 855
     shares owned by the Applied Bioscience International Inc. U.S. Retirement
     Savings Plan, a 401(k) Plan, for the account of Mr. Waechter.  Includes
     8,000 shares which may be acquired within the next 60 days pursuant to the
     exercise of options granted under the Company's Stock Incentive Program
     (1990).  Does not include 36,000 shares subject to options granted under
     the Company's Stock Incentive Program (1990) which are not currently
     exercisable and will not become exercisable within the next 60 days.

(8)  Includes 4,000 shares owned by a partnership of which Mr. Davis is a
     general partner and 500 shares held by Mr. Davis' mother, as to which
     Mr. Davis does not disclaim beneficial ownership.  Includes 16,750 shares
     which may be acquired within the next 60 days pursuant to the exercise of
     options granted under the Company's Stock Incentive Program (1990).  Does
     not include 50,250 shares subject to options granted under the Company's
     Stock Incentive Program (1990) which are not currently exercisable and will
     not become exercisable within the next 60 days.

(9)  Includes 25 shares which were transferred from the Pharmaco LSR
     International Inc. ESOP Program to the Applied Bioscience International
     Inc. U.S. Retirement Savings Plan, a 401(k) Plan, 25 shares owned by the
     Applied Bioscience International Inc. U.S. Retirement Savings Plan, a
     401(k) Plan, for the account of Dr. Defesche and 26,002 shares which may be
     acquired within the next 60 days pursuant to the exercise of options
     granted under the Company's Stock Incentive Program (1990).  Does not
     include 108,008 shares subject to options granted under the Company's Stock
     Incentive Program (1990) which are not currently exercisable and will not
     become exercisable within the next 60 days.


                                      -9-


<PAGE>


(10) Includes 97,500 shares held by the Highland-Mills Foundation, of which Dr.
     Highland is an officer and trustee, and 39,650 shares which may be acquired
     within the next 60 days pursuant to the exercise of options granted under
     the Company's Stock Incentive program (1990).  Does not include 20,444
     shares subject to options granted under the Company's Stock Incentive
     program (1990) which are not currently exercisable and will not become
     exercisable within the next 60 days.

(11) Includes 23,298 shares owned jointly by Mr. Timoney and his wife, as to
     which they share voting and investment power and 174,125 shares which may
     be acquired within the next 60 days pursuant to the exercise of options
     granted under the Company's Stock Incentive Program (1990). Does not
     include 45,296 shares issuable pursuant to a supplemental retirement
     arrangement maintained by the Company for Mr. Timoney and 14,667 shares
     subject to options granted under the Company's Stock Incentive Program
     (1990) which are not currently exercisable and will not become exercisable
     within the next 60 days.

(12) Includes 574,576 shares owned by the Grover C. Wrenn Revocable Trust, of
     which Mr. Wrenn is the sole trustee, beneficiary, and settlor; 2,870 shares
     owned by the Grover and Suzie Wrenn Foundation, of which Mr. Wrenn is an
     officer and director; 48,000 shares owned by the Wrenn Charitable Trust, of
     which Mr. Wrenn is a beneficiary; 22,374 shares owned by the Applied
     Bioscience International Inc. U.S. Retirement Savings Plan, a 401(k) Plan,
     for the account of Mr. Wrenn; 200,000 shares owned by Mr. Wrenn's wife; and
     54,761 shares which may be acquired within the next 60 days pursuant to the
     exercise of options granted under the Company's Stock Incentive Program
     (1990).  Does not include 92,667 shares subject to options granted under
     the Company's Stock  Incentive Program (1990) which are not currently
     exercisable and will not become exercisable within the next 60 days.

(13) Includes 884,285 shares which may be acquired within the next 60 days
     pursuant to the exercise of options granted under the Company's Stock
     Incentive Program (1990).  Does not include 336,592 shares subject to
     options granted under the Company's Stock Incentive Program (1990) which
     are not currently exercisable and will not become exercisable within the
     next 60 days.


                                      -10-


<PAGE>
                                     PART IV

Item 14.  Exhibits, Financial Statement Schedules and Reports on Form 8-K.

     (a)  Financial Statements and Financial Statement Schedules

           1.  The consolidated financial statements of the Company and its
               subsidiaries filed as part of this Report are listed in the
               attached Index to Financial Statements and Financial Statement
               Schedule.

           2.  The Schedule to the consolidated financial statements of the
               Company and its subsidiaries filed as part of this Report is
               listed in the attached Index to Financial Statements and
               Financial Statement Schedule.

           3.  The exhibits filed as part of this Report are listed in the Index
               to Exhibits immediately following the signature pages of this
               Report.

     (b)  Reports on Form 8-K.

     During the fourth quarter of 1994 the Company filed the following Reports
on Form 8-K with the Commission:

     None

     (c)  Exhibits

     Exhibit No.
     ----------


     3.    Articles of Incorporation and By-Laws:

     3.1   Certificate of Incorporation of the Registrant (composite copy as
amended to date), incorporated by reference to Exhibit 4.2 to the Registrant's
Registration Statement on Form S-3 (Registration No. 33-47505).

     3.2   By-Laws of the Registrant, as amended to date, incorporated by
reference to Exhibit 3.2 to the Registrant's Annual Report on Form 10-K for the
year ended December 31, 1993.

     4.    Instruments defining the rights of security holders, including
indentures.

     4.1   Certificate of Incorporation of the Registrant (composite copy as
amended to date), incorporated by reference to Exhibit 4.2 to the Registrant's
Registration Statement on Form S-3 (Registration No. 33-47505).


                                      -11-


<PAGE>

     4.2   By-Laws of the Registrant, as amended to date, incorporated by
reference to Exhibit 3.2 to the Registrant's Annual Report on Form 10-K for the
year ended December 31, 1993.

     10.   Material Contracts:

     10.1  Applied Bioscience International Inc. Employee Stock Purchase
Program (1988), incorporated by reference to Exhibit 10.1 to the Registrant's
Annual Report on Form 10-K for the year ended December 31, 1993.

     10.2  Life Science Research Limited Retirement Benefits Scheme and Trust
Deed, incorporated by reference to Exhibit 10.2 to the Registrant's Registration
Statement on Form S-1 (No. 33-11953).

     10.3  Applied Bioscience International Inc. U.S. Pension Plan and form of
Trust Agreement, incorporated by reference to Exhibit 10.3 to the Registrant's
Annual Report on Form 10-K for the year ended December 31, 1993.

     10.4  Agreement dated December 1, 1987 between the Company and Kenneth H.
Harper, incorporated by reference to Exhibit 10.4 to the Registrant's Annual
Report on Form 10-K for the year ended December 31, 1993.

     10.5  Agreement dated December 1, 1987 between the Company and John H.
Timoney, incorporated by reference to Exhibit 10.6 to the Registrant's Annual
Report on Form 10-K for the year ended December 31, 1993.

     10.6  Registration Rights Agreement dated September 7, 1990 by and among
Applied Bioscience International Inc. and Grover C. Wrenn, Joseph H. Highland,
Robert M. Wenger, Robert H. Harris and Joseph V. Rodricks, incorporated by
reference to Exhibit 10.19 to the Registrant's Annual Report on Form 10-K for
the year ended December 31, 1990.

     10.7  Employment Agreement dated September 7, 1990 by and among ENVIRON
International Corporation, Applied Bioscience International Inc. and Grover C.
Wrenn, incorporated by reference to Exhibit 10.21 to the Registrant's Annual
Report on Form 10-K for the year ended December 31, 1990.

     10.8  Employment Agreement dated September 7, 1990 by and among ENVIRON
International Corporation, Applied Bioscience International Inc. and Joseph H.
Highland, incorporated by reference to Exhibit 10.22 to the Registrant's Annual
Report on Form 10-K for the year ended December 31, 1990.

     10.9  Employment Agreement dated September 7, 1990 by and among ENVIRON
International Corporation, Applied Bioscience International Inc. and Joseph V.
Rodricks, incorporated by reference to Exhibit 10.23 to the Registrant's Annual
Report on Form 10-K for the year ended December 31, 1990.


                                      -12-


<PAGE>


     10.10     Employment Agreement dated September 7, 1990 by and among ENVIRON
International Corporation, Applied Bioscience International Inc. and Robert M.
Wenger, incorporated by reference to Exhibit 10.24 to the Registrant's Annual
Report on Form 10-K for the year ended December 31, 1990.

     10.11 Employment Agreement dated September 7, 1990 by and among ENVIRON
International Corporation, Applied Bioscience International Inc. and Robert H.
Harris, incorporated by reference to Exhibit 10.25 to the Registrant's Annual
Report on Form 10-K for the year ended December 31, 1990.

     10.12 Employment Agreement dated September 7, 1990 by and between Applied
Bioscience International Inc. and Kenneth H. Harper, incorporated by reference
to Exhibit 10.26 to the Registrant's Annual Report on Form 10-K for the year
ended December 31, 1990.

     10.13 Employment Agreement dated September 7, 1990 by and between Applied
Bioscience International Inc. and John H. Timoney, incorporated by reference to
Exhibit 10.27 to the Registrant's Annual Report on Form 10-K for the year ended
December 31, 1990.

     10.14 Partial Waiver and Amendment to Severance Agreement dated
September 7, 1990 by and between Applied Bioscience International Inc. and
Kenneth H. Harper, incorporated by reference to Exhibit 10.30 to the
Registrant's Annual Report on Form 10-K for the year ended December 31, 1990.

     10.15 Partial Waiver and Amendment to Severance Agreement dated
September 7, 1990 by and between Applied Bioscience International Inc. and John
H. Timoney, incorporated by reference to Exhibit 10.31 to the Registrant's
Annual Report on Form 10-K for the year ended December 31, 1990.

     10.16 Applied Bioscience International Inc. Stock Incentive Program
(1990), incorporated by reference to Exhibit 10.34 to the Registrant's Annual
Report on Form 10-K for the year ended December 31, 1990.

     10.17 Registration Rights Agreement dated February 28, 1992 by and among
the Registrant and Richard J. Hawkins, Nona F. Niland, John V. Farinacci, Summit
Ventures II, L.P. and Summit Ventures, L.P., incorporated by reference to
Exhibit 19.1 to the Registrant's Quarterly Report on Form 10-Q for the period
ended March 31, 1992.

     10.18 Partial Waiver to Severance Agreement dated February 28, 1992 by and
between the Registrant and Kenneth H. Harper, incorporated by reference to
Exhibit 19.6 to the Registrant's Quarterly Report on Form 10-Q for the period
ended March 31, 1992.

     10.19 Partial Waiver to Severance Agreement dated February 28, 1992 by and
between the Registrant and John H. Timoney, incorporated by reference to Exhibit
19.7 to the Registrant's Quarterly Report on Form 10-Q for the period ended
March 31, 1992.


                                      -13-


<PAGE>

     10.20 Amendments to Registration Rights Agreement dated February 28, 1992
by and among the Registrant and Grover C. Wrenn, Joseph H. Highland, Robert H.
Harris, Joseph V. Rodricks and Robert M. Wenger, incorporated by reference to
Exhibit 19.10 to the registrant's Quarterly Report on Form 10-Q for the period
ended March 31, 1992.

     10.21 Corporate Advisory Service Agreement dated February 5, 1993 between
Applied Bioscience International Inc. and Pharmaco LSR International Inc.,
incorporated by reference to Exhibit 10.38 to the Registrant's Annual Report on
Form 10-K for the year ended December 31, 1992.

     10.22 Corporate Advisory Service Agreement dated February 5, 1993 between
Applied Bioscience International Inc. and APBI Environmental Sciences Group,
Inc., incorporated by reference to Exhibit 10.39 to the Registrant's Annual
Report on Form 10-K for the year ended December 31, 1992.

     10.23 Letter Agreement dated April 30, 1993, between the Registrant and
Dr. Kenneth H. Harper, incorporated by reference to Exhibit 10.44 to the
Registrant's Quarterly Report on Form 10-Q for the period ended September 30,
1993.

     10.24 Letter Agreement dated April 30, 1993, between the Registrant and
John H. Timoney, incorporated by reference to Exhibit 10.45 to the Registrant's
Quarterly Report on Form 10-Q for the period ended September 30, 1993.

     10.25 Loan and Security Agreement dated as of May 24, 1994 among the
Registrant, APBI Environmental Sciences Group, Inc., APBI Finance Corporation,
APBI Investor Relations Inc., Pharmaco LSR International Inc., Pharmaco LSR Ltd.
(collectively, the "Borrowers") and ABN AMRO Bank N.V., Core States Bank, N.A.,
United Jersey Bank/Central, N.A. (collectively, the "Banks"), with Core States
Bank, N.A. as Agent, incorporated by reference to Exhibit 10.33 to the
Registrant's Quarterly Report on Form 10-Q for the period ended June 30, 1994.

     10.26 Revolving Credit Notes dated May 24, 1994, incorporated by reference
to Exhibit 10.34 to the Registrant's Quarterly Report on Form 10-Q for the
period ended June 30, 1994.

     10.27 Term Loan Notes dated May 24, 1994, incorporated by reference to
Exhibit 10.35 to the Registrant's Quarterly Report on Form 10-Q for the period
ended June 30, 1994.

     10.28 First Amendment dated as of February 27, 1995, to the Loan and
Security Agreement dated as of May 24, 1994, by and among the Borrowers, the
Bank and the Agent.

     10.29 APBI Retirement Savings Plan, incorporated by reference to Exhibit 4
to the Registrant's Registration Statement on Form S-8 (No. 33-56678).

     10.30 Separation Agreement by and between the Registrant and Swep T. Davis
dated as of January 31, 1995.


                                      -14-


<PAGE>


     10.31 Employment Agreement by and between Pharmaco LSR International Inc.
and Geoffrey K. Hogan dated as of January 6, 1995.

     10.32 Letter Agreement dated September 3, 1993, between the Registrant and
Stephen L. Waechter.

     10.33 Letter Agreement dated September 14, 1993, between the Registrant
and Stephen L. Waechter.

     11.   Statement re computation of per-share earnings.

     21.   Subsidiaries of the Registrant.

     23.   Consent of Arthur Andersen LLP.


                                      -15-


<PAGE>
                                   SIGNATURES

     Pursuant to the requirements of Section 13 or 15(d) of the Securities
Exchange Act of 1934, the registrant has duly caused this report to be signed on
its behalf by the undersigned, thereunto duly authorized.


                                  APPLIED BIOSCIENCE INTERNATIONAL INC.


Date:  May 5, 1995                By:  /s/ Stephen L. Waechter             
                                       ------------------------------------
                                       Name:  Stephen L. Waechter
                                       Title: Senior Vice President, Chief
                                              Financial Officer and Treasurer
                                              (Principal Financial Officer)


                                      -16-



<PAGE>
<TABLE><CAPTION>
                                    EXHIBIT INDEX

Exhibit                         Description                               Sequential
  No.                           -----------                               Page Number
  --                                                                      -----------
   <S>        <C>                                                        <C>
   3          Articles of Incorporation and By-Laws:

   3.1        Certificate of Incorporation of the Registrant (com-
              posite copy as amended to date), incorporated by
              reference to Exhibit 4.2 to the Registrant's Registra-
              tion Statement on Form S-3 (Registration No.
              33-47505)

   3.2        By-Laws of the Registrant, as amended to date, in-
              corporated by reference to Exhibit 3.2 to the Regis-
              trant's Annual Report on Form 10-K for the year
              ended December 31, 1993

   4          Instruments defining the rights of security holders,
              including indentures

   4.1        Certificate of Incorporation of the Registrant (com-
              posite copy as amended to date), incorporated by
              reference to Exhibit 4.2 to the Registrant's Registra-
              tion Statement on Form S-3 (Registration No.
              33-47505)

   4.2        By-Laws of the Registrant, as amended to date, in-
              corporated by reference to Exhibit 3.2 to the Regis-
              trant's Annual Report on Form 10-K for the year
              ended December 31, 1993

   10         Material Contracts:

   10.1       Applied Bioscience International Inc. Employee
              Stock Purchase Program (1988), incorporated by
              reference to Exhibit 10.1 to the Registrant's Annual
              Report on Form 10-K for the year ended December
              31, 1993.

   10.2       Life Science Research Limited Retirement Benefits
              Scheme and Trust Deed, incorporated by reference
              to Exhibit 10.2 to the Registrant's Registration
              Statement on Form S-1 (No. 33-11953)

</TABLE>

<PAGE>
<TABLE><CAPTION>

Exhibit                         Description                               Sequential
  No.                           -----------                               Page Number
  --                                                                      -----------
   <S>        <C>                                                        <C>
   10.3       Applied Bioscience International Inc. U.S. Pension
              Plan and form of Trust Agreement, incorporated by
              reference to Exhibit 10.3 to the Registrant's Annual
              Report on Form 10-K for the year ended December
              31, 1993

   10.4       Agreement dated December 1, 1987 between the
              Company and Kenneth H. Harper, incorporated by
              reference to Exhibit 10.4 to the Registrant's Annual
              Report on Form 10-K for the year ended December
              31, 1993

   10.5       Agreement dated December 1, 1987 between the
              Company and John H. Timoney, incorporated by
              reference to Exhibit 10.6 to the Registrant's Annual
              Report on Form 10-K for the year ended December
              31, 1993

   10.6       Registration Rights Agreement dated September 7,
              1990 by and among Applied Bioscience Interna-
              tional Inc. and Grover C. Wrenn, Joseph H. High-
              land, Robert M. Wenger, Robert H. Harris and
              Joseph V. Rodricks, incorporated by reference to
              Exhibit 10.19 to the Registrant's Annual Report on
              Form 10-K for the year ended December 31, 1990

   10.7       Employment Agreement dated September 7, 1990
              by and among ENVIRON International Corpora-
              tion, Applied Bioscience International Inc. and
              Grover C. Wrenn, incorporated by reference to Ex-
              hibit 10.21 to the Registrant's Annual Report on
              Form 10-K for the year ended December 31, 1990

   10.8       Employment Agreement dated September 7, 1990
              by and among ENVIRON International Corpora-
              tion, Applied Bioscience International Inc. and Jo-
              seph H. Highland, incorporated by reference to
              Exhibit 10.22 to the Registrant's Annual Report on
              Form 10-K for the year ended December 31, 1990

</TABLE>

<PAGE>
<TABLE><CAPTION>
Exhibit                         Description                               Sequential
  No.                           -----------                               Page Number
  --                                                                      -----------
   <S>        <C>                                                        <C>
   10.9       Employment Agreement dated September 7, 1990
              by and among ENVIRON International Corpora-
              tion, Applied Bioscience International Inc. and Jo-
              seph V. Rodricks, incorporated by reference to
              Exhibit 10.23 to the Registrant's Annual Report on
              Form 10-K for the year ended December 31, 1990

   10.10      Employment Agreement dated September 7, 1990
              by and among ENVIRON International Corpora-
              tion, Applied Bioscience International Inc. and
              Robert M. Wenger, incorporated by reference to
              Exhibit 10.24 to the Registrant's Annual Report on
              Form 10-K for the year ended December 31, 1990

   10.11      Employment Agreement dated September 7, 1990
              by and among ENVIRON International Corpora-
              tion, Applied Bioscience International Inc. and
              Robert H. Harris, incorporated by reference to Ex-
              hibit 10.25 to the Registrant's Annual Report on
              Form 10-K for the year ended December 31, 1990

   10.12      Employment Agreement dated September 7, 1990
              by and between Applied Bioscience International
              Inc. and Kenneth H. Harper, incorporated by refer-
              ence to Exhibit 10.26 to the Registrant's Annual
              Report on Form 10-K for the year ended
              December 31, 1990

   10.13      Employment Agreement dated September 7, 1990
              by and between Applied Bioscience International
              Inc. and John H. Timoney, incorporated by refer-
              ence to Exhibit 10.27 to the Registrant's Annual
              Report on Form 10-K for the year ended
              December 31, 1990

   10.14      Partial Waiver and Amendment to Severance
              Agreement dated September 7, 1990 by and be-
              tween Applied Bioscience International Inc. and
              Kenneth H. Harper, incorporated by reference to
              Exhibit 10.30 to the Registrant's Annual Report on
              Form 10-K for the year ended December 31, 1990

</TABLE>

<PAGE>
<TABLE><CAPTION>
Exhibit                         Description                               Sequential
  No.                           -----------                               Page Number
  --                                                                      -----------
   <S>        <C>                                                        <C>
   10.15      Partial Waiver and Amendment to Severance
              Agreement dated September 7, 1990 by and be-
              tween Applied Bioscience International Inc. and
              John H. Timoney, incorporated by reference to Ex-
              hibit 10.31 to the Registrant's Annual Report on
              Form 10-K for the year ended December 31, 1990

   10.16      Applied Bioscience International Inc. Stock Incen-
              tive Program (1990), incorporated by reference to
              Exhibit 10.34 to the Registrant's Annual Report on
              Form 10-K for the year ended December 31, 1990

   10.17      Registration Rights Agreement dated February 28,
              1992 by and among the Registrant and Richard J.
              Hawkins, Nona F. Niland, John V. Farinacci, Sum-
              mit Ventures II, L.P. and Summit Ventures, L.P.,
              incorporated by reference to Exhibit 19.1 to the
              Registrant's Quarterly Report on Form 10-Q for the
              period ended March 31, 1992

   10.18      Partial Waiver to Severance Agreement dated
              February 28, 1992 by and between the Registrant
              and Kenneth H. Harper, incorporated by reference
              to Exhibit 19.6 to the Registrant's Quarterly Report
              on Form 10-Q for the period ended March 31, 1992

   10.19      Partial Waiver to Severance Agreement dated
              February 28, 1992 by and between the Registrant
              and John H. Timoney, incorporated by reference to
              Exhibit 19.7 to the Registrant's Quarterly Report on
              Form 10-Q for the period ended March 31, 1992

   10.20      Amendments to Registration Rights Agreement
              dated February 28, 1992 by and among the Regis-
              trant and Grover C. Wrenn, Joseph H. Highland,
              Robert H. Harris, Joseph V. Rodricks and Robert
              M. Wenger, incorporated by reference to Exhibit
              19.10 to the registrant's Quarterly Report on Form
              10-Q for the period ended March 31, 1992

</TABLE>

<PAGE>
<TABLE><CAPTION>
Exhibit                         Description                               Sequential
  No.                           -----------                               Page Number
  --                                                                      -----------
   <S>        <C>                                                        <C>
   10.21      Corporate Advisory Service Agreement dated
              February 5, 1993 between Applied Bioscience In-
              ternational Inc. and Pharmaco LSR International
              Inc., incorporated by reference to Exhibit 10.38 to
              the Registrant's Annual Report on Form 10-K for
              the year ended December 31, 1992

   10.22      Corporate Advisory Service Agreement dated
              February 5, 1993 between Applied Bioscience In-
              ternational Inc. and APBI Environmental Sciences
              Group, Inc., incorporated by reference to Exhibit
              10.39 to the Registrant's Annual Report on Form
              10-K for the year ended December 31, 1992

   10.23      Letter Agreement dated April 30, 1993, between
              the Registrant and Dr. Kenneth H. Harper, incorpo-
              rated by reference to Exhibit 10.44 to the Regis-
              trant's Quarterly Report on Form 10-Q for the
              period ended September 30, 1993

   10.24      Letter Agreement dated April 30, 1993, between
              the Registrant and John H. Timoney, incorporated
              by reference to Exhibit 10.45 to the Registrant's
              Quarterly Report on Form 10-Q for the period
              ended September 30, 1993

   10.25      Loan and Security Agreement dated as of May 24,
              1994 among the Registrant, APBI Environmental
              Sciences Group, Inc., APBI Finance Corporation,
              APBI Investor Relations Inc., Pharmaco LSR Inter-
              national Inc., Pharmaco LSR Ltd. (collectively, the
              "Borrowers") and ABN AMRO Bank N.V., Core
              States Bank, N.A., United Jersey Bank/Central,
              N.A. (collectively, the "Banks"), with Core States
              Bank, N.A. as Agent, incorporated by reference to
              Exhibit 10.33 to the Registrant's Quarterly Report
              on Form 10-Q for the period ended June 30, 1994

   10.26      Revolving Credit Notes dated May 24, 1994, incor-
              porated by reference to Exhibit 10.34 to the Regis-
              trant's Quarterly Report on Form 10-Q for the
              period ended June 30, 1994

</TABLE>

<PAGE>
<TABLE><CAPTION>
Exhibit                        Description                               Sequential
  No.                          -----------                               Page Number
  --                                                                     -----------
   <S>        <C>                                                        <C>
   10.27      Term Loan Notes dated May 24, 1994, incorpo-
              rated by reference to Exhibit 10.35 to the Regis-
              trant's Quarterly Report on Form 10-Q for the
              period ended June 30, 1994

   * 10.28    First Amendment dated as of February 27, 1995, to
              the Loan and Security Agreement dated as of May
              24, 1994, by and among the Borrowers, the Bank
              and the Agent

   10.29      APBI Retirement Savings Plan, incorporated by
              reference to Exhibit 4 to the Registrant's Registra-
              tion Statement on Form S-8 (No. 33-56678)

   * 10.30    Separation Agreement by and between the Regis-
              trant and Swep T. Davis dated as of January 31,
              1995


   * 10.31    Employment Agreement by and between Pharmaco
              LSR International Inc. and Geoffrey K. Hogan
              dated as of January 6, 1995


    10.32     Letter Agreement dated September 3, 1993, be-
              tween the Registrant and Stephen L. Waechter

    10.33     Letter Agreement dated September 14, 1993, be-
              tween the Registrant and Stephen L. Waechter

     * 11     Statement re computation of per-share earnings

     * 21     Subsidiaries of the Registrant

     * 23     Consent of Arthur Andersen LLP







   *Previously filed

</TABLE>

                                                                  EXHIBIT 10.32



                                   [APPLIED BIOSCIENCE]
                                   [INTERNATIONAL INC.]
                                          [LOGO]



                                      GROVER C WRENN
                                        President




September 3, 1993




Mr. Stephen L Waechter
9 Scottish Autumn Court
Darnestown, MD 20878

Dear Steve:

This letter will confirm the terms of the offer of employment as Chief Financial
Officer of Applied Bioscience International Inc. as we discussed today. The 
position is located in our Arlington, Virginia offices, and you would report 
directly to me and have management responsibility for the entire APBI finance
organization.

The base salary for this position is $160,000. Beginning in 1994, you will be 
eligible for an additional target cash bonus opportunity of 60% of your base 
salary or $96,000. The actual amount of the cash bonus will be determined by 
the Economic Value Added (EVA) Incentive Compensation Plan introduced this year
as described in the enclosed materials. In lieu of a performance-based bonus in
1993, you will be provided a sign-on bonus of $15,000. Additionally, you will 
be guaranteed a minimum cash bonus of $25,000 in 1994.

Your compensation will also include annual stock option grants, subject to the 
approval of the Compensation and Stock Option Committee of the APBI Board of 
Directors. The executive compensation plan recently approved by the Committee 
provides for an annual option grant of 24,000 shares for your position. The 
options would vest ratably over three years and would have a ten-year exercise
period.

You will be covered by the APBI Employee Benefits Plan known as Selections which
is described in the enclosed folder. You would also be entitled to four weeks 
vacation per year.

Steve, I am excited about your joining APBI, and I look forward to working with
you. We have an attractive market position for future growth, but we lack the 
kind of financial management skill and leadership that you can provide. It is an
opportunity for you to make a real impact. I hope you will accept our offer and
will join us officially on September 13. In the meantime, I would welcome an 
opportunity for you to spend whatever time you can with Jamie and me beginning
to get up to speed on the current situation.






4350 North Fairfax Drive * Arlington, VA 22203  Tel: (703) 516-2443  
                                                Fax: (703) 516-2345

<PAGE>
Letter to Stephen L. Waechter
September 3, 1993
Page Two




I would like for you to plan to accompany Charles, Swep and me to New York on 
Monday, September 13 for a meeting with Citibank concerning the establishment 
of a new $70 million credit facility. The APBI Board of Directors meets on 
September 21 (dinner) and September 22. I would like for you to plan to attend.
It is my intention to propose your election as a director at that meeting, and 
I anticipate the Board's approval.

I will await your confirmation of our offer.

Very truly yours,

/s/ Grover C. Wrenn
- -------------------
Grover C. Wrenn
President and CEO

GCW/1s

Enclosure


                                                                  EXHIBIT 10.33



                                   [APPLIED BIOSCIENCE]
                                   [INTERNATIONAL INC.]
                                          [LOGO]





                                   September 14, 1993



      Mr. Stephen L. Waechter
      Chief Financial Officer
      Applied Bioscience International Inc.
      4350 North Fairfax Drive, Suite 300
      Arlington, Virginia 22203

      Dear Steve:

              APPLIED BIOSCIENCE INTERNATIONAL INC. (the "Company")
      considers the establishment and maintenance of a sound and vital
      management to be essential to protecting and enhancing the best
      interests of the Company and its shareholders. In this
      connection, the Company recognizes that, as is the case with many
      publicly held corporations, the possibility of a change in
      control may exist and that such possibility, and the uncertainty
      and questions which it may raise among management may result in
      the departure or distraction of management personnel to the
      detriment of the Company and its shareholders. Accordingly, the
      Company's Board of Directors has determined that should the
      Company become subject to any proposed or threatened change in
      the control of the Company, it is imperative that the Company and
      the Board of Directors be able to rely upon you to remain in your
      position and to provide advice, if requested, as to the best
      interests of the Company.

              In order to induce you to remain in the employ of the
      Company, this letter agreement sets forth the severance benefits
      which the Company agrees will be provided to you in the event
      your employment with the Company is terminated subsequent to a
      "change in control of the Company" (as defined in Section 1
      hereof) under the circumstances described below.

               1.    CHANGE IN CONTROL. No benefits shall be payable
      hereunder unless there shall have been a change in control of the
      Company, as set forth below, and your employment by the Company
      shall thereafter have been terminated in accordance with Section
      3 below. For purposes of this Agreement, a "change in control of
      the Company" shall mean a change in control of a nature that
      would be required to be reported in response to Item 6(e) of
      Schedule 14A of Regulation 14A promulgated under the Securities
      Exchange Act of 1934, as amended ("Exchange Act"); provided that,
      without limitation, such a change in control shall be deemed to

      4350 North Fairfax Drive * Arlington, VA 22203  Tel: (703) 516-2490 
                                                      Fax: (703) 516-2494



<PAGE>

      Mr. Stephen L. Waechter
      September 14, 1993
      Page 2

      have occurred if (i) any "person" (as such term is used in
      Sections 13(d) and 14(d)(2) of the Exchange Act) is or becomes
      the beneficial owner, directly or indirectly, of securities of
      the Company representing fifty percent (50%) or more of the
      combined voting power of the Company's then outstanding
      securities; or (ii) during any period of two consecutive years,
      individuals who at the beginning of such period constitute the
      Board of Directors of the Company (the "Board") cease for any
      reason to constitute at least a majority thereof unless the
      election, or the nomination for election by the Company's
      shareholders, of each new director was approved by a vote of at
      lease two-thirds of the directors then still in office who were
      directors at the beginning of the period.

           2.    TERMINATION FOLLOWING CHANGE IN CONTROL.

                        (a) If any of the events described in Section 1 hereof
      constituting a change in control of the Company shall have
      occurred, you shall be entitled to the benefits provided in
      Section 3 hereof if the Company subsequently terminates your
      employment unless (i) such termination is (A) because of your
      death or (B) by the Company for Disability; or (ii) such
      termination is (A) by the Company and occurs more than one (1)
      year subsequent to the date of such change of control or (B) you
      unilaterally terminate your employment after a change in control.

                        (b) "Disability" as used herein means that as a result
      of your incapacity due to physical or mental illness, you shall
      have been absent from your duties with the Company on a full-time
      basis for one hundred eighty (180) consecutive days (or for
      shorter period aggregating not less than one hundred eighty (180)
      days during any period of twelve (12) months).

             3.    COMPENSATION UPON TERMINATION. If, within the first
      year following a change of control, the Company shall terminate
      your employment other than pursuant to the reasons set forth in
      paragraph 2(a) hereof, then the Company shall be obligated to
      continue to pay to you as severance pay, the following amounts:

                        (a) your full base salary together with benefits
      through the one year anniversary of the change of control at the
      rate in effect at the time of your termination;

                        (b) all stock options granted to you under the
      Company's stock option plans prior to such termination shall vest


<PAGE>

      Mr. Stephen L. Waechter
      September 14, 1993
      Page 3

      as of the date of such termination and you will have the right,
      for a period of one hundred eighty (180) days following such
      termination, to exercise all such stock options which have not
      expired.

              4.    LAPSE. Should you voluntarily leave employment (other
      than after a change in control as provided in Paragraph 3) this
      Agreement shall lapse and be of no other force and effect and no
      compensation will be payable to you hereunder.

              5.     SUCCESSORS; BINDING AGREEMENT.

                          (a) The Company will require any successor
      (whether direct or indirect, by purchase, merger, consolidation
      or otherwise) to all or substantially all of the business and/or
      assets of the Company, to expressly assume and agree to perform
      this Agreement in the same manner and to the same extent that the
      Company would be required to perform it if no such succession had
      taken place.

                          (b) This Agreement shall inure to the benefit of
      and be enforceable by your personal or legal representatives,
      executors, administrators, successors, heirs, distributees,
      devisees and legatees.

              6.    NOTICE. For the purposes of this Agreement, notices
      and all other communications provided for in the Agreement shall
      be in writing and shall be deemed to have been duly given when
      delivered or mailed by registered mail, return receipt requested,
      postage prepaid, addressed to the respective addresses set forth
      on the first page of this Agreement, provided that all notices to
      the Company shall be directed to the attention of the Chief
      Executive Officer of the Company with a copy of the Secretary of
      the Company, or to such other address as either party may have
      furnished to the other in writing in accordance herewith, except
      that notices of change of address shall be effective only upon
      receipt.

              7.    MISCELLANEOUS. No provisions of this Agreement may be
      modified, waived or discharged unless such waiver, modification
      or discharge is agreed to in writing signed by you and such
      officer as may be specifically designated by the Board of
      Directors of the Company. No waiver by either party hereto at
      any time of any breach by the party hereto of, or compliance
      with, any condition or provision of this Agreement to be

<PAGE>

       Mr. Stephen L. Waechter
       September 14, 1993
       Page 4

       performed by such other party shall be deemed a waiver of similar
       or dissimilar provisions or conditions at the same or at any
       prior or subsequent time. No agreement or representations, oral
       or otherwise, express or implied, with respect to the subject
       matter hereof have been made by either party which are not set
       forth expressly in this Agreement. The validity, interpretation,
       construction and performance of this Agreement shall be governed
       by the laws of the State of Delaware.

               8.    VALIDITY. The invalidity or unenforceability of any
       provisions of this Agreement shall not effect the validity or
       enforceability of any other provision of this Agreement, which
       shall remain in full force and effect.

               9.    COUNTERPARTS. This Agreement may be executed in one or
       more counterparts, each of which shall be deemed to be an
       original but all of which together will constitute one and the
       same instrument.

               If this letter correctly sets forth our agreement on the
       subject matter hereof, kindly sign and return to the Company the
       enclosed copy of this letter which will then constitute our
       agreement on this subject.

                                   Sincerely,

                                   APPLIED BIOSCIENCE INTERNATIONAL
                                       INC.

                                   By:  /s/ Grover C. Wrenn
                                        -----------------------
                                        Grover C. Wrenn
                                        Chief Executive Officer

       Agreed to this 16th day of
       September, 1993.

       /s/ Stephen L. Waechter
       ------------------------
       Stephen L. Waechter




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